[Pharmacogenetics of MXA SNPs in interferon-beta treated multiple sclerosis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

Gene-disease associations inferred from text-mining the literature.
DisGeNET evidence - LITERATURE

[Genetic analyses of celiac disease in a Spanish population confirm association with CELIAC3 but not with CELIAC4.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genotyping of MYO9B and molecular HLA-DQ2 typing were performed on 62 RCD II and EATL patients, 421 uncomplicated CD patients, and 1624 controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Linkage and association was shown between the MYOC polymorphisms and high myopia in our family-based association study. The SNP rs235858 at the 3 flanking region showed the highest degree of confidence for association.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study supports NAPG as a candidate for susceptibility to bipolar disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings suggest that HTR5A gene could play an important role in the pathogenesis of bipolar disorder in our population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We also evaluated the association between GSTs and NAT2 and the risk factors for gastric cancer such as alcohol consumption, smoking, H. pylori infection, family history of gastric cancer, and tumor location.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased risk of gastrointestinal lymphoma in carriers of the 657del5 NBS1 gene mutation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association analyses of NCR3 polymorphisms with P. falciparum mild malaria.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with schizophrenia in the Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Should NF2 mutation screening be undertaken in patients with an apparently isolated vestibular schwannoma?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We found that intracellular Propionibacterium acnes, a possible causative agent of sarcoidosis, activated NF-kappaB in both NOD1- and NOD2-dependent manners.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[variation in individual genes from the NLR family as well as interactions within this group of innate immune receptor genes could play a role in AD pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that the G908R mutation of the CARD15/NOD2 gene, as well as the T allele and TT genotype of the CD14 promoter are associated with increased susceptibility for developing sarcoidosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We studied gene variants of NOS-I (rs2682826;rs1353939;rs2293049;rs693534) and NOS-III (rs2070744;rs1799983;rs891512) in a total of 571 cases (167 German suicide attempters, 92 Caucasian suicide completers and 312 German healthy subjects).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To further clarify the possible involvement of NOS1 with suicide, we carried out an association study of NOS1 gene polymorphisms with completed suicide.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This is the first study to identify the repeat polymorphisms in the iNOS gene that are associated with severity of asthma and eosinophils.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that the polymorphic (CCTTT)n repeat in the iNOS promoter region might be involved in the development of UC, especially in those who have ever smoked.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Endothelial nitric oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effect modification by smoking on the association between genetic polymorphisms in oxidative stress genes and colorectal cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The finding of eNOS T-786C SNP could be used to significantly differentiate between the presence and severity of cerebral vasospasm (p = 0.04).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[NOTCH signaling pathway is essential in T-cell development and NOTCH1 mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this population-based case control study (n = 455 cases; 527 controls), we examined the only identified nonsynonymous polymorphism (Ala394Thr; rs2305160) in the largest circadian gene, neuronal PAS domain protein 2 (NPAS2), in order to examine its impact on NHL risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genes HMGCS2, FDPS, RAFTLIN, ACAD8, NPC2, and ABCG1 were associated with AD at a significance level of P < or = 0.05 in this sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results demonstrate that NPHS1 and NPHS2 mutations are also present in Chinese sporadic NS patients, suggesting that genetic changes of nephrin and podocin may play pathogenetic roles in some patients with sporadic steroid resistant NS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results do suggest that variants of the ANF gene might be involved in the determination of left ventricular hypertrophy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study provides further evidence for an effect of NPSR1 on asthma, atopy and atopic asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For ADAM33, NPSR1, and CYFIP2, the associations with asthma or asthma-related phenotypes have been studied in East Asian populations such as Chinese and Japanese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To analyze the association of G protein-coupled receptor 154 with asthma and total and mite-specific IgE levels in a population of the Caribbean Coast of Colombia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common variants rs12649641, rs2342676 and rs6857530 in the 5' region of NPY2R are associated with obesity in Danish white subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Associations between obesity-related phenotypes and four genes in these pathways - leptin (LEP), leptin receptor (LEPR), neuropeptide Y2 receptor (NPY2R) and peptide YY (PYY) were examined in CARDIA Study participants (aged 18-30 at recruitment in 1985-6).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[our data suggested that CYP1B1 germ line-inactivating mutations might increase the incidence of HCA in women with HNF1alpha mutations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results of our study of Turkish prostate cancer patients suggests that mutation of the NQO1 gene may effect the serum PSA and alkaline phosphatase levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results show that genetic variation in the PXR encoding gene, which has been associated with altered activity of PXR, is strongly associated with susceptibility to IBD, CD, and UC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These new findings suggest that observed associations between NRG1 and schizophrenia may be mediated through functional interaction not just with ERBB4, but with other members of the NRG and ERBB families.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The result supports that the NRG3 gene is a susceptibility gene for schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The observations suggest that NYX may have independent effects on myopia and night blindness.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Rapid detection of the hOGG1 Ser326Cys polymorphism using LightCycler technology.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of hOGG1 genotype with life style and oxidative DNA damage among Chinese ethnic populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[hOGG1 SER326CYS genetic polymorphism in a Turkish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of the kappa-opioid system with alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequency of the minor allele was significantly lower in the subjects with chronic pain when compared with the group with acute postoperative pain (0.079 versus 0.158; P = 0.009 by chi2 test).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Postoperative pain management following orthognathic surgery in consideration of individual differences--is the antinociceptive effect of fentanyl related to the genotype involving nucleotide at OPRM1?.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated 29 single nucleotide polymorphisms (SNPs) within the P2RX7 gene and adjacent genes in a sample of 1000 German Caucasian patients suffering from recurrent major depressive disorder (MDD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PADI4 gene in multiple sclerosis: a family-based association study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ADPRT and XRCC1 polymorphisms confer host susceptibility to GCA, which might result from reduced ADPRT-XRCC1 interaction and attenuated base excision repair capacity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated whether polymorphisms at the visfatin/PBEF locus influence the risk of type 2 diabetes (T2D).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[were also negative when the quantitative traits of weight and BMI were tested.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Programmed cell death 1 gene polymorphisms is associated with ankylosing spondylitis in Chinese Han population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, we found significant associations with both the diagnosis of MDD and remission in response to antidepressants with SNPs in the PDE11A gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of Per1 and Npas2 with autistic disorder: support for the clock genes/social timing hypothesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations of the KRAS, BRAF, and PIK3CA genes have been reported in colorectal cancer (CRC), associated with resistance to epidermal growth factor receptor (EGFR)-targeted monoclonal antibody therapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[BRAF genotype is correlated with PFS and OS in KRAS wild type mCRC patients, which is independent of cetuximab treatment. PIK3CA mutation, loss of PTEN expression, EGFR GCN and HER2 GCN have no predictive value for response to treatment with cetuximab, neither individually nor in combination with other markers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ This study is one of the first comprehensive mutational analyses of major genes in a specific signaling pathway in a sizeable cohort of lung adenocarcinomas. Our results suggest the majority of gain-of-function mutations within kinase genes in the EGFR signaling pathway have already been identified. Our findings also implicate FGFR4 in the pathogenesis of a subset of lung adenocarcinomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There was a significant difference in the frequency distribution of the urokinase gene 3-UTR C/T polymorphism in bladder cancer patients as compared to the normal control group (p < 0.05), but no significant difference in allelic frequencies or in carriage rates between bladder cancer patients and normal controls were observed. Our study suggests that uroki]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PLP1 and GPM6B intragenic copy number analysis by MAPH in 262 patients with hypomyelinating leukodystrophies: Identification of one partial triplication and two partial deletions of PLP1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variation in the adiponutrin gene influences its expression and associates with obesity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The smallest region of allelic imbalance contains the podocalyxin-like (PODXL) gene, which we evaluate here as a candidate prostate cancer aggressiveness gene mapping to 7q32-q33.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polbeta may play a role in the breast carcinogenesis and the Lys289Met polymorphism of the polbeta gene may be considered as an independent, early, molecular diagnostic marker in breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[An intronic polymorphism associated with increased XRCC1 expression, reduced apoptosis and familial breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic susceptibility to distinct bladder cancer subphenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[POLG1 in idiopathic Parkinson disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This prompted us to carry out a detailed analysis of the coding region and intron-exon boundaries of POLG1 in Finnish patients with idiopathic sporadic Parkinson disease (PD) and in nonparkinsonian controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The polymorphism of Glu298Asp eNOS gene in dead cases may be useful for determining the cause of death in CHD cases in the Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of polymorphisms in the paraoxonase 1 gene with breast cancer incidence in the CPS-II Nutrition Cohort.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the KDR and POSTN genes: association with breast cancer susceptibility and prognosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study has shown that both Pro12Ala and His447His polymorphisms of PPAR-gamma are associated with PCOS in a Korean population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of genetic variation in peroxisome proliferator-activated receptors in the polycystic ovary syndrome (PCOS): an original case-control study followed by systematic review and meta-analysis of existing evidence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A population-attributable risk of approximately 50% for the Pro12Pro genotype indicates that testing for the Pro12Ala of the PPARG gene in addition to the already identified clinical risk factors may become a useful tool to further reduce the risk of PPARgamma agonist-induced fluid retention and edema in patients with type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Germline mutations of the perforin gene are a frequent occurrence in childhood anaplastic large cell lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We study the association between three protein kinase C, eta gene polymorphisms (+8134C/T, rs912620, rs959728), and susceptibility to rheumatoid arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Prion protein gene codon 129 modulates clinical course of neurological Wilson disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[TNF-alpha 308 G/A, PAI-1 4G/4G, and EPCR mutations influence the risk of severe sepsis in children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PRPF31 is one of four pre-mRNA splicing factors identified as causing autosomal dominant retinitis pigmentosa, with incomplete penetrance being the unique feature associated with mutations in this gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in PRPF31, RHO, and PRPH2 were found in low frequencies (1 of 9 autosomal dominant RP families) in Chinese patients, and the PRPF31 and PRPH2 truncating mutations were novel.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our goal was to identify a potential contribution of the PSMD9 gene to type 2 diabetes in Italians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Autoinflammatory gene mutations in Behet's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The COX-2 G/C -765 polymorphism may modulate the occurrence of cerebrovascular ischemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[-765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A recent study has reported that MAGI1, MAGI2, and protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1; located on 7q31.3) gene products regulate the NRG1-ERBB4 signaling pathway, and PTPRZ1 is associated with schizophrenia in a Caucasian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated whether putatively functional single nucleotide polymorphisms (SNPs) in genes related to CIN (CENPF, ESPL1, NEK2, PTTG1, ZWILCH, ZWINT) affect breast cancer (BC) risk and clinical outcome in a Swedish cohort of 749 incident BC cases with detailed clinical data and up to 15 years of follow-up and 1493 matched controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings support previous data showing that VDR SNPs modulate the risk for TB in West Africans and suggest that variation within DC-SIGN and PTX3 also affect the disease outcome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the analysis of a very large data set suggests that genetic polymorphisms in PVRL2 may influence MS severity and supports the possibility that viral factors may contribute to the clinical course of MS, consistent with previous reports.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Some common mutations of RAD50 and NBS1 in western populations do not contribute significantly to Chinese non-BRCA1/2 hereditary breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study confirms that HLA class III region seems involved in familial predisposition to atopy, and C4B gene probably acts as a marker of a more restricted subregion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Rgs 2 gene polymorphisms as modulators of anxiety in humans?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In an effort to identify additional gene polymorphisms in which variants have been implicated in asthma, we investigated the genetic polymorphisms in RUNX1 to evaluate it as a potential candidate gene for a host genetic study of asthma and IgE production.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The p11 protein (also called S100A10), which plays a pivotal role in the dynamic modulation of serotonergic 1B receptor function, has been implicated in the pathogenesis of major depressive disorder (MDD) and the therapeutic mechanisms of antidepressant action.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The relationship between severe myoclonic epilepsy of infancy (SMEI or Dravet syndrome) and the related syndrome SMEI-borderland (SMEB) with mutations in the sodium channel alpha 1 subunit gene SCN1A is well established.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The CFTR gene was first analyzed in all patients by denaturing high-performance liquid chromatography followed by direct sequencing; whereas, the sodium channel non-voltage-gated 1 alpha (SCNN1A), sodium channel non-voltage-gated 1 beta (SCNN1B), and sodium channel non-voltage-gated 1 gamma (SCNN1G) subunits of the ENaC gene were analyzed by sequencing in the five patients who carried only one CF mutation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings indicate that SDC3 polymorphisms could contribute to the link between female hyperandrogenism and obesity and suggest a novel potential role for SDC3 as a modulator of gonadal steroid function.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study provides a possible association between the selectin gene polymorphisms and the rapid progression to ESRD in IgAN patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[s l-selectin gene polymorphisms are associated with GD susceptibility in Chinese patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased sP-selectin concentrations are associated with VTE and genotype status. sP-selectin concentrations are lower in individuals carrying the P-selectin Pro715 variant than in those without this variant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationship between alpha-1 antitrypsin deficient genotypes S and Z and lung cancer in Jordanian lung cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We confirm previous observations that variants of the beta adrenergic receptor and of nitric oxide synthase are associated with prematurity, and suggest that genetic variants of the placental antifibrinolytic plasminogen activator inhibitor-2, and thrombomodulin and alpha adducin may be contributors to risk of spontaneous preterm birth. LEVEL OF EVIDENCE: II]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The polymorphism of megsin A23167G is associated with$$$ susceptibility and progression of IgA nephropathy in Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hypofibrinolysis, associated with the 4G allele of the PAI-1 gene, was found significantly more often in women with endometriosis compared with controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This data provides additional evidence supporting an important role for PAI-1 in the pathogenesis of aggressive fibromatosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Significance of factor V, prothrombin, MTHFR, and PAI-1 genotypes in childhood cerebral thrombosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The influence of metabolic syndrome components on plasma PAI-1 concentrations is modified by the PAI-1 4G/5G genotype and ethnicity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PAI-1 gene expression decreased over time after CPB. We found a link between PAI-1 genotype, PAI gene expression, and transfusion of coagulation products after cardiac surgery.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A 12-bp deletion in the 5'-flanking region of the SERPINH1 gene affects promoter activity and protects against preterm premature rupture of membranes in African Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Similarly, homozygosity for the C1420T SHMT polymorphism also had a 2.6-fold increased risk (95% CI: 1.1, 5.9) of developing CRC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SLC12A3 (solute carrier family 12 member sodium/chloride 3) polymorphisms are associated with end-stage renal disease in diabetic nephropathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of chromosome 5q31-32 and psoriasis: confirmation of a susceptibility locus but no association with SNPs within SLC22A4 and SLC22A5.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[DAT VNTR 10/10 genotype may be associated with an endophenotype of late-life depression with executive dysfunction that responds preferentially to methylphenidate added to a selective serotonin reuptake inhibitor, which warrants replication in a large sample. Copyright (c) 2007 John Wiley & Sons, Ltd.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of C/T polymorphism in intron 14 of the dopamine transporter gene (rs40184) with major depression in a northeastern Thai population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the S allele of the SLC6A4 promoter variant is associated with overweight being an independent genetic risk factor for obesity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[X-linked creatine transporter (SLC6A8) mutations in about 1% of males with mental retardation of unknown etiology.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association study of polymorphisms in glycine transporter with schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We concluded that at least one susceptibility locus for schizophrenia may be located within or nearby SLC6A5, whereas SLC1A4, SLC1A5 and SLC6A9 are unlikely to be major susceptibility genes for schizophrenia in the Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Neither of the SNCB SNPs examined were associated with PD overall or in strata, and haplotype analyses were negative as well.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of the gene coding for copper/zinc superoxide dismutase (SOD1) in patients with Japanese encephalitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Manganese superoxide dismutase polymorphism in chronic pelvic pain syndrome patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The MnSOD mutant C allele may increase the susceptibility to DILI, and GSTM1 null genotype may be related to anti-tuberculosis drug-induced hepatotoxicity. Determination of the MnSOD and GSTM1 genotypes may help identify patients at high risk for DILI.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, we tested 27 genes (ACE, BDNF, CH25H, CHRNB2, CST3, CTSD, DAPK1, GALP, hCG2039140, IL1B, LMNA, LOC439999, LOC651924, MAPT, MTHFR, MYH13, PCK1, PGBD1, PRNP, PSEN1, SORCS1, SORL1, TF, TFAM, TNK1, GWA_14q32.13, and GWA_7p15.2), all showing significant association with AD risk in the AlzGene meta-analyses, in a large collection of family-based samples comprised of 4,180 subjects from over 1,300 pedigrees.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SORL1 has recently been identified as a major genetic contributor to increased risk for late-onset Alzheimer disease (AD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our aim was to assess the gut mucosal gene expression and genetic association of SPINK1, -2, -4, and -5 in the Dutch CD population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results are the first to demonstrate the existence of T-593A promoter polymorphism of the OPN gene and significant association with risk of developing nephrolithiasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ In summary, we replicated our previous finding and found evidence for SNPs in the 5 region of the SREBF1c gene to be associated with the risk of type 2 diabetes and plasma glucose concentration.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We evaluated the association of variants in the sterol regulatory element-binding factor 1 gene (SREBF1) with type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[, LKB1 gene mutations were relatively rare in Japanese patients with lung cancer compared with Caucasian patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study presents genetic evidence suggesting a potential role of SULT2A1, but not STS, in the inherited AA excess of PCOS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The effect of genetic variants in the thrombin activatable fibrinolysis inhibitor (TAFI) gene on TAFI-antigen levels, clot lysis time and the risk of venous thrombosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of TAP1 and TAP2 gene polymorphism in idiopathic bronchiectasis in children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[TAP1 gene polymorphisms and nasopharyngeal carcinoma risk in a Tunisian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Of the seven polymorphisms, three of which (LMP7 codons 145, TAP1 codons 637, and TAP2 codons 651) were observed to have statistically significant association with HBV infection (P < 0.05).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We selected 208 hepatitis B patients and 213 healthy volunteers to examine whether polymorphisms or haplotypes of the TBX21 gene promoter were associated with hepatitis B virus (HBV) infection in the Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of TBX21 T-1993C polymorphism with viral persistence but not disease progression in hepatitis B virus carriers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Individuals carrying at least one arginine at position 74 of the DRbeta1 chain (denoted the R- genotype) have a significantly increased risk of GD, as do individuals homozygous for the single nucleotide protein (SNP) in exon 33 of the Tg gene (denoted the CC genotype).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The thyroglobulin (Tg) is a major autoantigen for GD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Transforming growth factor-beta 1 gene polymorphisms in Korean patients with pre-eclampsia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IL6, IL10 and TGFB1 gene polymorphisms in coeliac disease: differences between DQ2 positive and negative patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants of TGFB1 and TGFBR2 genes may contribute to the risk of developing gastric cancer in an eastern Chinese population in Yixing city.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The risk of dialysis access thrombosis is related to the transforming growth factor-beta1 production haplotype and is modified by polymorphisms in the plasminogen activator inhibitor-type 1 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A pilot study of genetic polymorphisms and hemodialysis vascular access thrombosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cytokine gene polymorphisms can alter the effect of Bacillus Calmette-Gurin (BCG) immunotherapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic susceptibility of epidermal growth factor +61A>G and transforming growth factor beta1 -509C>T gene polymorphisms with gallbladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We aimed at analyzing whether 7 different common variants in genes coding for 2 key members of the TGF-beta signalling pathway (TGFB1 and TGFBR1) are associated with bladder cancer risk and prognosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The previously observed associations with risk of radiation-induced subcutaneous fibrosis could not be replicated in the present study. Further studies are needed to elucidate the influence of genetic variation upon normal tissue radiosensitivity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[TGF-beta (-509)CC genotype may be the protective factor for the pneumoconiosis. TGF-beta (+915)GC genotype may be a susceptible factor for the pneumoconiosis. The workers of carrying TGF-beta (-509) * T and (+915) * C alleles are more susceptible to pneumoconiosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The polymorphism of 8570G > A in TIM4 may be associated with allergic asthma in the population of Han nationality from Hubei province of China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results showed that SNPs in the TLR2, 4 and 9 genes were not significantly associated with susceptibility to BD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lack of Toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of CD14 and Toll-like receptor-2 (TLR2) in patients with ulcerative colitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results rather point to another as yet unidentified variant within or close to TLR4 that might confer susceptibility to sarcoidosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of TLR4 single-nucleotide polymorphisms and sarcoidosis in Greek patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Potential reasons for absence of modifier effect include the basolateral location of TLR4 receptors on respiratory epithelium, or because inflammatory response to PA in the CF airway is so overwhelming that even a blunted response (as suggested for the 299G allele) results in increased inflammation and lung damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The possible role of TLR4 polymorphism in the outcome of severe acute pancreatitis requires further investigations in a larger series of patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The G allele at position +1174 (located in intron 1 of TLR9) is closely associated with an increased risk of SLE (p = 0.029).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These observations suggest that the TLR9 promoter polymorphism C-1237T might affect AE susceptibility in particular in patients with the intrinsic variant of AE.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[HLA-DQA1*0201-DQB1*0201 haplotype is involved in susceptibility, conferring 5.53 times more risk of developing this disease. EBM rating: B-2b.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of TNF-alpha and LT-alpha genes in multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study described the haplotypic structure across a region of chromosome 6 including the tumour necrosis factor (TNF) gene, and investigated its influence on the aetiology of myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We found that genes previously identified by their association with subclinical features of knee OA or progression were also associated with clinical knee OA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association of osteoprotegerin gene polymorphisms with periodontitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Based on our recent finding that TACI is mutated in patients with common variable immunodeficiency, of whom more than 30% suffer from autoimmune conditions, we analyzed TACI in humans with SLE.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of our study is to analyze whether TNF gene promoter (-308 G/A; -857 G/A) and TNF receptor polymorphisms (TNFR1 MspA1 I exon 1 and TNFR2 Nla III exon 6) show involvement in CAD predisposition in a group of Italian patients compared with healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results indicate that there are genetic differences between psoriasis vulgaris patients with and without joint manifestations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Prevalence and spectrum of mutations in the sarcomeric troponin T and I genes in a cohort of Spanish cardiac hypertrophy patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role in autism etiology of seven candidate genes in the serotonin metabolic and neurotransmission pathways and mapping to autism linkage regions (SLC6A4, HTR1A, HTR1D, HTR2A, HTR5A, TPH1 and ITGB3) was analyzed in a sample of 186 nuclear families.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Family-based association study of TPH1 and TPH2 polymorphisms in autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interactions between genes involved in the antioxidant defence system and breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We examined associations between 54 polymorphisms that tag the known common variants (minor allele frequency > 0.05) in 10 genes involved in oxidative damage repair (CAT, SOD1, SOD2, GPX1, GPX4, GSR, TXN, TXN2, TXNRD1, and TXNRD2) and survival in 4,470 women with breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, we evaluated the risk of acute graft-versus-host disease (GVHD) associated with genetic variation in recipient and donor MTHFR and TS genotypes to assess whether genotype alters the efficacy of MTX in acute GVHD prophylaxis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study examines the response to dexamethasone-doxorubicin-vincristine (DAV) therapy, followed by conditioning regimen and autologous stem cells transplantation (ASCT) in patients with multiple myeloma in relation with the presence of polymorphisms in genes involved in drug metabolism (GSTP1) and DNA synthesis (TYMS).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Since a substitution of serine by tyrosine at codon 18, exon 3 (S18Y polymorphism) of the UCH-L1 gene exhibits a protective effect against the development of degenerative disease such as sporadic Parkinson's disease (PD) in several different ethnic groups, we hypothesized that UCH-L1 gene S18Y polymorphism may have that same effect on the pathologic process of AD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, these results show the UGT2B17 deletion polymorphism is associated with prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conducted a case-control study in a cohort of 517 PD cases and 518 ethnically matched controls to investigate the association of ubiquitin specific proteases USP24 rs487230 C>T, USP40 rs1048603 C>T, and ubiquitin thiolesterase UCHL1 rs5030732 A>C polymorphisms with the risk of PD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To assess the significance of polymorphisms of the genes for angiotensin-converting enzyme (ACE), angiotensin-converting enzyme 2 (ACE2) and urotensin II (UTS2) as risk factors for essential hypertension in two populations from north-western China, we enrolled 198 patients with essential hypertension and 131 healthy controls from the Han population and 120 patients with essential hypertension and 102 healthy controls from the Dongxiang population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SNPs in strong linkage disequilibrium and haplotypes constituting these SNPs in the versican gene are associated with IAs suggesting that variation in or near the versican gene plays a role in susceptibility to IAs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To determine whether -Taq I T/C and -Fok I C/T polymorphisms of vitamin D receptor (VDR) gene are associated with the familial aggregation of hepatitis B virus (HBV) infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[VDR gene polymorphism is probably an influence factor on the genetic susceptibility of HBV infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms and clinical outcome in recurrent ovarian cancer treated with cyclophosphamide and bevacizumab.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[VHL mutation analysis in patients with isolated central nervous system haemangioblastoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association study of sporadic Parkinson's disease genetic risk factors in patients from Russia by APEX technology.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Centrosome-related genes, genetic variation, and risk of breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To test whether genetic variations in WT1 and WIT1 (gene immediately 5' to WT1) associate with focal segmental glomerulosclerosis (FSGS), patients with biopsy-proven idiopathic and HIV-1-associated FSGS were enrolled in a multicenter study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Patients were 101 men (93.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Results suggested that 399Q allele might act as a recessive allele in its association with colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[genetic variants of the genes involved in the DSB repair pathway may play a role in the etiology of glioma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study shows that AT1R and AT2R are expressed locally in gastric cancer and that the combination of AT1R expression and ACE I/D gene polymorphism correlates with nodal spread in intestinal type gastric cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Platelet glycoprotein Ia 807C/T and 873G/A polymorphisms in patients with venous thromboembolism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[this study suggests that the activating KIR2DS4 may serve as CML susceptive gene to trigger leukemia development, while KIR2DS3 is possibly a protect gene of ALL.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, a functional polymorphism in the 5' flanking region of the leptin gene (LEP -2548 G/A) was found to increase susceptibility for non-small cell lung cancer odds ratio (OR), 1.97; 95% confidence interval (CI), 1.13-3.43.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We evaluated the frequency of ABCB1 polymorphisms (2677G/T>A and 3435C>T) and studied the association between the polymorphisms and clinical outcomes of paclitaxel-based chemotherapy in advanced gastric cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Investigation of GSTT1, GSTM1 and NQO1 genes polymorphisms in myelodysplastic syndromes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ADH1C genotype modifies the association between alcohol consumption and diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Overall, APOC3 promoter variants were associated with a greater likelihood of MetS compared to wild type C-482T (OR: 4.3; 95% CI: 2.2, 8.6 p <0.0001), T-455C (OR: 3.6; 95% CI: 2.0, 6.7 p <0.0001).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The APOA5 Ser19Trp, APOA5 -12,238T>C, APOA4 Thr347Ser, APOC3 -482C>T and APOC3 3238C>G (SstI) polymorphisms were analyzed in a representative population sample of 3138 men and women from France, including 932 individuals with metabolic syndrome and 2206 without metabolic syndrome, as defined by the NCEP criteria.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ApoE epsilon2/epsilon3/epsilon4 gene polymorphism is a determinant of the relative proportion of apolipoprotein C-III to E. Carriers of the unfavourable E4 allele present the highest ApoCIII/ApoE ratio and are twofold more frequent among individuals affected by MetSyn.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We replicated genetic associations for CD with IL23R, ATG16L1, IRGM, NKX2-3, 1q24, 10q21, 5p13, and PTPN2 and report evidence for associations with HERC2 and CCNY.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Using voxel-based morphometry in 30 asymptomatic mutation carriers (MC) with mutations in four different genes for PD and 100 healthy controls, we identified an increase in gray matter volume (GMV) in the striatum in asymptomatic Parkin, PINK1, ATP13A2 and, to a much lesser extent, in LRRK2 MC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We confirm that ATP13A2 homozygous mutations are associated with human parkinsonism, and expand the associated genotypic and clinical spectrum, by describing a homozygous missense mutation in this gene in a patient with a phenotype milder than that initially associated with ATP13A2 mutations (Kufor-Rakeb syndrome).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[on roles of ATP13A2 variant in Asians or other populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutation analysis of ATP13A2 gene in Chinese patients with familial autosomal recessive early-onset parkinsonism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Metabolic gene variants and risk of non-Hodgkin's lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variations in xenobiotic metabolic pathway genes, personal hair dye use, and risk of non-Hodgkin lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SNPs in four genes (ERCC5, ERCC2, WRN, and BRCA1) were associated with altered risk of NHL and diffuse large B-cell lymphoma (DLBCL), the major B cell subtype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of gene polymorphisms in the DNA repair gene XPD with risk of non-Hodgkin's lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study shows that factor V Leiden mutation, and investigated platelet GP Ia, and GP IIIa polymorphisms frequently coexist.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Varied prevalence of factor V G1691A (Leiden) and prothrombin G20210A single nucleotide polymorphisms among Arabs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional evidence suggests that the 001Msp, fcrl3_3, fcrl3_5, and fcrl3_6 SNPs could cause changes in B cell signaling and activation pathways that could account for their association with GD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The -5T/C polymorphism of the platelet glycoprotein GPIb alpha Kozak gene is implicated in the pathogenesis of TIA. C allele is an independent risk factor for TIA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[HLA and MICA associations with head and neck squamous cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between human African trypanosomiasis and the IL6 gene in a Congolese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Using Phase II HapMap data, we demonstrate that there are a set of polymorphisms, spanning genes from prolyl 4-hydroxylase (P4HA2) through interferon regulatory factor 1 (IRF1) with equivalent statistical evidence of association to the reported SLC22A4 variant and that each, by itself, could entirely explain the IBD5 association to CD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The prothrombotic Pl(A2) allele of platelet fibrinogen receptor GPIIb/IIIa increased the risk of metastases in RCC in men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The 584C/T polymorphism of the EL gene was associated with AMI independently of HDL-C levels and thus may be involved in the pathogenesis of AMI.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[RNFL thickness was significantly increased in the early stage and decreased in the late stage in the 11778 group than in the 14484 group.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The three LHON primary mutations are rare in general Chinese populations. The optimized MAS-PCR assay provides an easier, faster and more cost-effective method for detection of the three LHON primary mutations, making it practical for clinical diagnosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Chinese individuals >or=50 years of age carrying the AG genotype of NFKBIA may be at an increased risk of developing CRC, and the GG genotype of NFKBIA may be considered as a prognostic factor for Swedish CRC patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[NOD2 polymorphism screening should be used to optimize donor selection and antimicrobial prophylaxis to reduce the occurrence of aGVHD and TRM following allogeneic HSCT.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that the association of PON1 Q192R with symptoms of depression in occupationally exposed groups may be driven by exposure to toxins that everyone in the general population is exposed to rather than exposure to toxins specifically used by sheep dippers or Gulf War veterans, or that other mechanisms underlie the association.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A novel single nucleotide polymorphism, IVS2 -97A>T, in the prostaglandin F2alpha receptor gene was identified among the Malaysian patients with glaucoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Prevalence of SLC22A4 1672T and SLC22A5 -207C combination defined TC haplotype in Hungarian ulcerative colitis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present preliminary study investigated possible association of the temporal lobe epilepsy (TLE) with the polymorphisms in several 5HT-related genes, including serotonin transporter (5HTT), monoamine oxidase A (MAO-A) and serotonin receptors 5HT-1A, 5HT-1B and 5HT-2C.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There was no association between five single nucleotide polymorphisms or haplotypes of the OPN gene and aortic diameter or AAA expansion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A case-control study investigating the role of sulfotransferase 1A1 polymorphism in head and neck cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings have suggested that there was a significant association between brain tumor and SULT1A1*2 allele (A allele that is also known as His allele) and this allele is an important risk factor in the development of meningiomal brain tumors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest MMP-2 and TIMP-2 genotypes play a crucial role in gastric cancer invasion, but not with development of gastric cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants in XRCC2: new insights into colorectal cancer tumorigenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This investigation indicates that DARC is not a genetic trait significantly associated with or predisposing to Behcet's disease, at least in Caucasian Italians. However, the role of this polymorphism in the development and in the clinical course of the disease awaits further investigation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between deletion polymorphism of the angiotensin-converting enzyme gene and cerebral atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Frequency and distribution in East Asia of 12 mutations identified in the SLC25A13 gene of Japanese patients with citrin deficiency.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[On the basis of our findings and earlier reports, MYH mutation screening should be considered if all of the following criteria are fulfilled: (i) presence of classical or attenuated polyposis coli, (ii) absence of a pathogenic APC mutation, and (iii) a family history compatible with an autosomal recessive mode of inheritance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that breast cancer phenotype and outcome can be influenced by common functional polymorphisms in MMP genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Promoter polymorphisms in matrix metalloproteinases and their inhibitors: few associations with breast cancer susceptibility and progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A new platelet polymorphism Duv(a+), localized within the RGD binding domain of glycoprotein IIIa, is associated with neonatal thrombocytopenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A recurrent large Alu-mediated deletion in the hypoxanthine phosphoribosyltransferase (HPRT1) gene associated with Lesch-Nyhan syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This deletion reduces TNP1 expression and may cause human male infertility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The His645Asp polymorphism of the histamine metabolising enzyme ABP1 is related to severity of ulcerative colitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ACE gene deletion polymorphism may be operative in response to medical treatment that included ACE inhibitors in patients with HF.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[: This study suggests that ACE I/D polymorphism might represent a predisposing factor to severe heart failure, independently of well-known prognostic markers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effect of the polymorphism of the angiotensin-converting enzyme gene on the plasma angiotensin II levels and the risk of chronic heart failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Angiotensin-converting-enzyme gene polymorphism and heart failure: a case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Angiotensin II type 2 receptor gene polymorphism in Caucasian children with a wide spectrum of congenital anomalies of the kidney and urinary tract.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in AGXT, a locus mapped to 2q37.3, cause deficiency of liver-specific alanine:glyoxylate aminotransferase (AGT), the metabolic error in type 1 primary hyperoxaluria (PH1).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genotype at the Asp148Glu SNP site in the APEX gene of the base excision repair (BER) pathway was associated with childhood cancer in survivors (P = 0.001, significant even after multiple test adjustment), due to the enhanced frequency of the APEX Asp148 allele among survivors in comparison to that of their partners.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For the prediction of ONFH, it is useful to analyze ApoB C7623T and plasma ApoB/ApoA1 ratio before the administration of steroids.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Germline BCL-2 sequence variants and inherited predisposition to prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in mitochondrial genes and prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analogously, results from DBMA found a five-locus combination, two in ST6GALNAC2 and three in C1GALT1, which was associated with IgAN predisposition, eGFR, and renal outcome of patients with IgAN.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A polymorphism in the promoter region of the CD86 (B7.2) gene is associated with systemic sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comprehensive assessment of P21 polymorphisms and lung cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[CTLA-4 gene polymorphisms and natural soluble CTLA-4 protein in psoriasis vulgaris.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IL-6 174 G/C, FVL, and Cathepsin G (Ars 125 Ser) did not influence the incidence and mortality of severe sepsis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[indicate that common alleles of the CYP11alpha promoter pentannucleotide (tttta)n polymorphism in this population of Han Chinese women were P4, P6 and P8, and allele P6 was the most common one.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lung cancer susceptibility model based on age, family history and genetic variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[D2 dopamine receptor gene polymorphisms among African-Americans and Mexican-Americans: a lung cancer case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In contrast to controls, no association was found between the DRD2 genotypes and smoking among lung cancer cases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The dopamine receptor/transport gene polymorphisms are associated with the risk of NSCLC among smokers. The data show that the polymorphisms resulting in lower dopamine bioavailability were associated with increased risk of NSCLC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that C-reactive protein plays a role in development of dementia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aims of the study were as follows: (1) To identify the differences in spinal body mass density (BMD) in relation to polymorphism in vitamin D receptor (VDR) and estrogen receptor-alpha (ERalpha) genes in untreated women with postmenopausal osteoporosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our aim was to evaluate the effect of four hemostatic genetic variants, namely fibrinogen-beta-455G/A, factor XIII (FXIII) V34L, plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphisms and factor V Leiden (FVL) mutation on survival of critically ill patients with severe sepsis or septic shock.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Carriers of 92Asn had increased risk of MI in CARE and increased odds of CHD in WOSCOPS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[FKBP52 is likely to play a role in growth and development of the male genitalia, since it is expressed in the genital skin of prepubertal boys; however alterations in the sequence and in the expression of the FKBP4 gene are not a common cause of non-syndromic hypospadias.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comprehensive mutation analysis of GLDC, AMT, and GCSH in nonketotic hyperglycinemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The C allele in the CX37 gene might be associated with the susceptibility to CAD and potentially plays an important role in the manifestation of coronary atherosclerosis among Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[GNAS1 T393C is a novel independent host factor for disease progression in patients with ICC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meal-unrelated dyspepsia in a U.S. community study is associated with the homozygous 825T or C alleles of GNbeta3 protein. Candidate genes controlling adrenergic, serotonergic, and CCKergic functions do not appear to be associated with dyspepsia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms in GSTM1, GSTT1, GSTP1, GSTM3 and the susceptibility to gallbladder cancer in North India.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The finding that haptoglobin 2-2 genotype is a risk factor for anaemia in children in a malaria-endemic area may reflect the reduced ability of the Hp2-2 polymer to scavenge free haemoglobin-iron following malaria-induced haemolysis. The magnitude of the effect of haptoglobin genotype (4 g/l Hb difference, p = 0.0009) was comparable to that of G6PD deficiency or HbAS (3 g/l difference, p = 0.03; and 2 g/l difference, p = 0.68, respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[HJV p.A310G polymorphism and two intronic variants were found, but none of these alterations were associated with digenic inheritance with the HFE gene. Our data indicate that HJV and HAMP functional mutations are not frequent in these patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Frequency of the S65C mutation of HFE and iron overload in 309 subjects heterozygous for C282Y.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between ulcerative growth and hypoxia inducible factor-1alpha polymorphisms in colorectal cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that HIF1A1 C1772T and G1790A polymorphisms are not involved in the progression or metastasis of CRC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[HLA typing in Indian children with NS helps to predict relapse frequency and steroid resistance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[According to HLA typing, the results support the hypothesis that IgM nephropathy is a different entity from minimal change nephrotic syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest an important role for HTR3B in major depression in women and also raise the possibility that previously proposed disease-associated SNPs in the HTR3A/B region in Caucasians are in linkage disequilibrium with haplotype block 2 of HTR3B in the Japanese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Further studies are needed to explore contributions from other genetic factors such as rare variants in these genes and variation outside of these genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of single nucleotide polymorphisms of cytokine genes in spontaneous preterm delivery.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The carriage of proinflammatory IL-1B-511 and HP vacA m1 genotypes was associated with the development of gastric IM in the Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of the variations in IL-28RA gene and their association with allergic rhinitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated 30 patients with idiopathic pulmonary fibrosis (IPF) and 103 healthy volunteers for the cytokines polymorphisms of the IL-1alpha, IL-1beta, IL-1R, IL-1RA, IL-2, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor-alpha, interferon-gamma, transforming growth factor-beta, IL-1beta, IL-2, IL-4, and IL-4RA genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aims of the present case-control study were to examine polymorphisms in the IL-6, transforming growth factor (TGF)-beta 1, tumour necrosis factor (TNF)-alpha and interleukin-1 (IL-1)Ra genes in patients with IPF (n = 22) -compared to healthy controls (n = 140).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Crosstalk between the 2 chemokines CXCL8 and CCL5 may contribute to the susceptibility to SSc.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[were obtained with haplotype analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of drug resistance gene polymorphism appears to be an indicator of the response to chemotherapy in advanced ovarian cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The LRRK2 Gly2385Arg variant is not a significant risk factor for ET in our population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of common haplotypes of surfactant protein A1 and A2 (SFTPA1 and SFTPA2) genes with severity of lung disease in cystic fibrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MECP2 coding sequence and 3'UTR variation in 172 unrelated autistic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic factors for lone atrial fibrillation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: a case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants of nNOS, but not iNOS, may be biomarkers for susceptibility to CM, and the risk of CM associated with sunburns and moles may be modulated by nNOS variant genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PARP-1 -410 and PARP-1 -1672 haplotypes were associated with an increased risk for AD (global haplotype association p value=0.019), and, in addition, PARP-1 haplotypes increased the risk of AD by interaction with the IL-1A -889 allele 2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A91V perforin variation in healthy subjects and FHLH patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[our findings suggest that variants within the S100B gene predispose to a psychotic subtype of BPAD, possibly via alteration of gene expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, in the present study population, SCARB1 polymorphisms not only show associations with plasma levels of total and low-density lipoprotein cholesterol, respectively, but also with the risk for PAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No significant differences were observed in the F206L polymorphism of L-selectin, or the G241R and E469K polymorphisms in the ICAM-1 gene in CD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To further characterize these parameters, the present study analyzed the expression of three isoforms of septin 3 (A, B, and C) in fetal and adult human brains and polymorphism of the septin 3 exon 11 microsatellite in control, pure Alzheimer's disease (AD), Lewy body variant (LBV) of AD, and Parkinson's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Recent studies have proposed that the serine protease inhibitor E2 (SERPINE2) was a novel susceptibility gene for chronic obstructive pulmonary disease (COPD) in Caucasians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SERPINE2 polymorphisms and chronic obstructive pulmonary disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of the SIM1 contribution to polygenic obesity in the French population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[this report does not support a substantial overall association between the evaluated polymorphisms in the one-carbon metabolism pathway and breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The effect of dopamine D2, D5 receptor and transporter (SLC6A3) polymorphisms on the cue-elicited heroin craving in Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We performed a genetic association study using four functional polymorphisms of the dopamine receptor 4 (DRD4), dopamine transporter (DAT), mono-amino-oxidase A (MAOA) and cathecol-O-methyl-transferase (COMT) genes in 103 patients with chronic daily headache associated with DA (CDHDA).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[When numeric scores were assigned to both the SNP and demographic data, and sequentially combined by a simple algorithm in a risk model, the composite score was found to be linearly related to lung cancer risk with a bimodal distribution.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In 253 Gilman probable or definite MSA patients, 457 possible, probable, and definite MSA cases and 1472 controls, a frequency difference for the individual tagging SNPs or tag-defined haplotypes was not detected. No effect was observed of polymorphisms on the pathological expression of MSA in pathologically confirmed cases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In contrast to the previously reported significant association between TAS2R16 and alcohol dependence, we found no evidence that TAS2R38 haplotypes influence alcohol dependence in the COGA dataset.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SNPs discovered to date are suitable for risk prediction while additional SNPs discovered in the future may identify more subjects at higher risk. Men identified as high risk by SNP-based testing may be targeted for PCa screening or chemoprevention. The clinical impact on improving the effectiveness of these interventions can be and should be assessed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We confirm recent reports that 8q24 variants identified to be associated with prostate cancer in men of European descent are also associated with prostate cancer in African Americans. Our report is the first to find evidence of association between SNPs near MSMB and prostate cancer in African Americans. Of note, rs7000448 is in strong linkage disequilibrium with rs10761581 in NCOA4, a SNP that has been implicated to be independently associated, with respect to the widely reported SNP rs10993994 in the nearby gene MSMB, with prostate cancer in men of European descent.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Number of prostate cancer risk alleles may identify possibly 'insignificant' disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[rs1447295, rs6983561 and rs4430796 showed strong evidence of an association with prostate cancer after adjustments for age.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We identified associations between prostate cancer susceptibility SNPs and clinical end points. The rs61752561 in KLK3 and rs2735839 in the KLK2-KLK3 intergenic region were strongly associated with prostate cancer-specific survival, and rs10486567 in the 7JAZF1 gene were associated with biochemical recurrence. A larger study will be required to independently validate these findings and determine the role of these SNPs in prognostic models.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Transforming growth factor-beta1 polymorphisms in patients with brucellosis: an association between codon 10 and 25 polymorphisms and brucellosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[-238 G>A polymorphism of tumor necrosis factor alpha gene (TNFA) is associated with alcoholic liver cirrhosis in alcoholic Spanish men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), produced by endotoxin-activated Kupffer cells, play a key role in the pathogenesis of alcoholic liver cirrhosis (ALC).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate the effect of single nucleotide polymorphisms (SNPs) of the upstream stimulatory factor (USF) 1 and 2 genes on the onset of Alzheimer's disease (AD), a case-control study was performed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Urotensin II gene may contribute to the genetic susceptibility to gestational diabetes mellitus in northern Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[VEGF genetic variability is associated with increased risk of developing Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Recent evidences indicate that polymorphisms within the promoter region of the vascular endothelial growth factor (VEGF) gene may elevate the risk for Alzheimer's disease (AD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Previous studies in three independent cohorts have shown that the rs1858830 C allele variant in the promoter region of the MET gene on chromosome 7q31 is associated with autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations of hemochromatosis gene in volunteer blood donors and Chilean porphyria cutanea tarda patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[OAS1 gene haplotype confers susceptibility to multiple sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A functional OAS1 SNP, AA genotype, confers susceptibility to MS and the GG genotype may protect against increased disease activity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We therefore investigated in a cohort of HIV-infected Tanzanian patients whether the Asp299Gly TLR4 polymorphism is associated with the development of active tuberculosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest that cat but not dog ownership substantially increases the risk of eczema within the first year of life in children with FLG loss-of-function variants, but not amongst those without.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Examination of tetrahydrobiopterin pathway genes in autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association analysis of age-at-onset in Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in GHRL may have a modest impact on BMI in European Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic mutations associated with cigarette smoking in pancreatic cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results support polygenic genetics for success in abstaining from smoking, overlap with genetics of substance dependence and memory, and nominate gene variants for selective influences on therapeutic responses to bupropion vs NRT.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The distribution of PTPN22 polymorphism did not reveal any association with TA in Turkey.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Allele and haplotype frequency distribution in PTPN22 gene across variable ethnic groups: Implications for genetic association studies for autoimmune diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Collectively, these findings confirm that the COX-2 -765G>C polymorphism is a risk factor for the development of bladder cancer and can provide a plausible mechanistic explanation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study evaluated the relationship between autism spectrum disorders (ASDs) and polymorphisms of PTGS2 (the gene encoding Cox-2) with 151 Korean family trios including children with ASDs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[COX2 and p53 risk-alleles coexist in COPD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For the first time, we provide evidence that functional polymorphisms in the COX2 gene may influence the risk of vitiligo in Han Chinese populations, suggesting new clues that help to clarify the pathogenesis of vitiligo.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest that the homozygous CC genotype of the COX2.8473 T > C polymorphism may be associated with sarcoidosis susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results confirm the protective effect of NSAID use on colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genomic basis of cerebral palsy: a HuGE systematic literature review.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[G-765C COX-2 gene promoter polymorphism and risk of atherosclerosis after kidney transplantation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Participants with the PLA2 BanI GG or the COX2 rs4648308 AG genotypes had a higher risk of IFN-alpha-induced depression (odds ratio = 3.1 and 3.5, respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Specific PTGIS and TBXAS1 variants may affect breast cancer susceptibility, but common variants in PTGS1, PTGS2, PTGES, PTGDS, and PGDS have no major role in breast cancer susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PTEN identified as important risk factor of chronic obstructive pulmonary disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The presence of the GP VI 13254C allele is an independent predictor of premature MI.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of candidate genes in occurrence and growth of colorectal adenomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study demonstrates that mutations in each part of the EGFR pathway were associated with different clinicopathologic features in patients with NSCLCs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We show significant association between ERG gene rearrangements and PTEN genomic aberrations in subset of PCA. Our analysis also provides further support for the observation that homozygous PTEN deletions can occur within the subset of HGPIN lesions, and shows accumulating genetic aberrations with disease progression, evidenced by higher detection in PCA than in HGPIN and more PTEN homozygous deletions in GS 8-10 than in 6-7.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Concomitant PI3K-AKT and p53 alterations in endometrial carcinomas are associated with poor prognosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[TAS2R38 polymorphisms are an important factor in determining ND in AAs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the genes encoding the 4 RET ligands, GDNF, NTN, ARTN, PSPN, and susceptibility to Hirschsprung disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Large multifunctional protease LMP2 (Arg60-->His), LMP7 (Lys145-->Gln) and PSMA6 (C(-8)-->G) gene allelic polymorphisms in 147 young patients with essential hypertension and in 208 practically healthy people were determinated.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results indicate that the PSMA6 variant rs1048990 is a risk factor of myocardial infarction in the Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Several genome-wide association studies identified the chr15q25.1 region, which includes three nicotinic cholinergic receptor genes (CHRNA5-B4) and the cell proliferation gene (PSMA4), for its association with lung cancer risk in Caucasians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation of PSCA gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common variants on chromosome 6p22.1 are associated with schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of SPINK1 gene mutation and CFTR gene polymorphisms in patients with pancreas divisum presenting with idiopathic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Congenital thrombotic risk factors in beta-thalassemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variations in NR2A have the greatest relevance for human alcohol dependence among the glutamatergic genes selected for their known alteration of alcohol effects in animal models.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage `checkpoints` and lung cancer susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate the association between the polymorphisms of the KU70 and X-ray repair cross complementing group 7 (XRCC7) genes and the risk of bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that PRKCSH gene is not a major genetic cause of PCLD and there may be at least another locus responsible for the disease in Taiwan.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SNPs at T2DM susceptibility loci identified through GWAS in populations of European ancestry show similar effects in Asian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study suggests that a small subset of GWAS-identified SNPs may increase T2D susceptibility by modulating expression of nearby transcripts in adipose or muscle.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We performed a genome-wide case-control study and found that a nonsynonymous SNP in PRKCH encoding a member of protein kinase C (PKCC eta) was significantly associated with brain infarction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results from this study provide evidence for the presence of genes affecting T2DM on chromosomes 4q, 12q, and 22q in AA; 6p in EA; 2p in AI; and 13q in MA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Clinical information of 963 heart failure patients was analyzed according to race, inhibitor-1 genotype, treatment with beta-blockers and mortality patterns.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The PPARGC1A Gly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Twenty-three polymorphisms in 22 potential PAD candidate genes (F2, FGB, MTHFR, ITGB3, ACE, AGT, IL6, CCL2, ICAM1, SELE, MMP9, PPARG, MMP1, ADD1, P2RY12, LIPC, PLA2G7, SCARB1, MMP3, MTTP, LPA, CHRNA3) showed a significant association in individual studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association of olanzapine-induced weight gain with peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism in patients with schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor- (PPAR)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effect of peroxisome proliferator-activated receptors-gamma and co-activator-1alpha genetic polymorphisms on plasma adiponectin levels and susceptibility of non-alcoholic fatty liver disease in Chinese people.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our prospective study suggests that genetic variation in IL10 and possibly TLR4 is associated with prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest that variants in FLNB and CRTAP at 3p are involved in BMD regulation in southern Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Individual single tube genotyping and DNA pooling by allele-specific PCR to uncover associations of polymorphisms with complex diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Peroxisome proliferator-activated receptor gamma polymorphisms and coronary heart disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PPARD variation is clearly associated with a phenotype of reduced stature in both adults and children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There is genetic heterogeneity in CRC associations in Americans of African versus European descent.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cytochrome P450 oxidoreductase deficiency: identification and characterization of biallelic mutations and genotype-phenotype correlations in 35 Japanese patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Paraoxonase gene mutations in amyotrophic lateral sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings contribute to the increasing weight of evidence that genetic variants in the paraoxonase gene cluster are associated with amyotrophic lateral sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of genetic factors with clinical peculiarities of hypertensive disease in patients with burdened familial anamnesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of genetic damage in a Brazilian population occupationally exposed to pesticides and its correlation with polymorphisms in metabolizing genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of the present study was to identify an association between the -A162G polymorphism of the promoter region of the human PON1 gene and the risk of sALS in a Polish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Recently, non-synonymous coding single nucleotide polymorphisms (SNPs), known to lower serum PON activity, have been associated with sporadic ALS (SALS) in a Polish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The measurement of the lactonase activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The PON1 192 AA genotype may play an important role as a risk factor for ovarian cancer in the Turkish population and the A and L alleles may be associated with early onset of disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No significant differences were found for PON1 activity between normal and obese women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In patients, the QQ genotype was statistically less frequent, while the RR genotype frequency was somewhat less than in controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MC1R variation and melanoma risk in the Swedish population in relation to clinical and pathological parameters.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Severe obesity in Han Chinese was associated with 3 novel common SNPs for ESR1 and PPARgamma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel Twinkle (PEO1) gene mutations in mendelian progressive external ophthalmoplegia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[we find some evidence that common variants in mismatch repair genes may contribute to survival of patients with colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Population-based study of the association of variants in mismatch repair genes with prostate cancer risk and outcomes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in phospholipid transfer protein modulates lipoprotein profiles in hyperalphalipoproteinemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The minor A allele at PLIN4 was associated with higher risk of MS at baseline, whereas the PLIN6 SNP was associated with better weight loss, suggesting that these polymorphisms may predict outcome strategies based on multidisciplinary treatment for OCA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings support the view that relevant relationships between circadian clocks and the metabolic syndrome in humans exist.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility `hot-spot`.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic profiling of genes from the oxidative stress pathway among North and South Indians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic deficiency of plasma lipoprotein-associated phospholipase A2 (PLA2G7 V297F null mutation) and risk of Alzheimer's disease in Japan.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We sought to determine whether allelic variants in the human PAFAH gene (Arg92His, Ile198Thr, and Ala379Val) contribute to variability in PAF-AH activity in patient plasma obtained within 72 h of ARDS diagnosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Neurodegeneration associated with genetic defects in phospholipase A(2).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this first study applying new TFC to patients suspected of ARVD/C, 64% of probable ARVD/C patients and 11% of family members were additionally diagnosed. ECG criteria and pathogenic mutations especially contributed to new diagnosis. Newly proposed TFC have a major impact in increasing diagnostic yield of ARVD/C.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To verify their findings and to determine the nature of the association in a subset of our PD patients we have analyzed two PITX3 SNPs (rs2281983 and rs4919621) in 265 PD patients and compared them with 210 age-matched healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[, we report the variation in genes of a pathway that has been involved in dopaminergic neuron differentiation and survival.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Rare mutations in the PIK3CA gene contribute to aggressive endometrial cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of peptidase inhibitor 3 (elafin) are associated with acute respiratory distress syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Progesterone receptor (PROGINS) polymorphism and the risk of ovarian cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Androgen, progesterone, and FSH receptor polymorphisms in ovarian cancer risk and outcome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Allele and haplotype frequencies in the hPR are significantly different among women with preterm birth and women with preterm birth plus a family history of preterm birth. This suggests the hPR gene may be a candidate for association with preterm birth or familial preterm birth.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variants in circadian genes and prostate cancer risk: a population-based study in China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest that none of the investigated PEDF polymorphisms is likely a major risk factor for exudative AMD in a white European population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To determine whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and response to treatment with photodynamic therapy (PDT) for age-related macular degeneration (AMD) in a Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Platelet-endothelial cell adhesion molecule-1 gene polymorphism and its soluble level are associated with ischemic stroke.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Transcriptionally less active prodynorphin promoter alleles are associated with temporal lobe epilepsy: a case-control study and meta-analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interaction between BRCA1/BRCA2 and ATM/ATR associate with breast cancer susceptibility in a Chinese Han population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This genetic epidemiological study demonstrated that 26.65% of the prelingual deafness in Northern Chinese patients can be detected at younger ages by genetic testing of three common hearing loss genes (GJB2, SLC26A4 and mtDNA A1555G), and thus, early intervention measures could be undertaken to help them in language acquisition.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The number of mutant alleles of SLC26A4, but not the presence of cochlear anomalies, has a significant association with severity of hearing loss in ears with EVA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Screening of SLC26A4 (PDS) gene mutation in cochlear implant recipients with inner ear malformation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate the hot spot mutation of SLC26A4 gene and its incidence among patients with moderate to profound sensorineural hearing loss (SNHL) and to analyze the epidemiology of enlarged vestibular aqueduct syndrome in China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic diagnosis and imaging results are the 2 predominant factors determining the outcome in children with cochlear implants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study was unable to find an association between KIT mutational status and clinical outcome of imatinib in Korean patients with advanced GISTs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PDE11A, PDE9A, and PDE1A are unlikely to play an important role in antidepressant outcome in this sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the results suggest a primary effect of PDE8B variants on cAMP levels in the thyroid.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We identified novel candidate genes for treatment response to risperidone and provide evidence that one of these additionally may confer susceptibility to schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the SNPs of the PDE4D (83T/C) and IL-1 (-889C/T) were associated with increased risk for the development of IS in Northern Han Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of PDE11A global haplotype with major depression and antidepressant drug response.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggested that the PD1 gene contributed to a genetic susceptibility to SSPE.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[rs1130409/T1865G (APEX1), rs1799782/T22142C (XRCC1), rs25487/G23990A (XRCC1), rs4989588/T3337A (FEN1), rs4989586/ G3259A (FEN1), rs4989587/C3315T (FEN1), and rs1050525/G6941T (PCNA) with breast cancer susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Several gene variants in the Glycolysis were associated with schizophrenia in three independent samples.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide analysis of survival in early-stage non-small-cell lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results revealed an association between high myopia and AC and AG dinucleotide repeat lengths in the PAX6 P1 promoter, indicating the involvement of PAX6 in the pathogenesis of high myopia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PAX6 mutations cause panocular malformations that vary considerably in pattern and severity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate the association of polymorphisms of PAX1 gene with congenital scoliosis (CS) in Chinese Han population and the relationship between the PAX1 gene polymorphisms and the clinical phenotypes of CS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Postoperative bleeding in cardiac surgery: the role of tranexamic acid in patients homozygous for the 5G polymorphism of the plasminogen activator inhibitor-1 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thrombophilic gene polymorphisms are risk factors for unexplained infertility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hereditary thrombophilia promotes induction of nephrosclerosis leading to activation of intraglomerular blood clotting which contributes to CGN progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We tested four genes phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit (GABRB3) for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A population-based association study of candidate genes for depression and sleep disturbance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pharmacological effects of lipid-lowering drugs recapitulate with a larger amplitude the phenotypic effects of common variants within their target genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results imply that OPTC and EPYC are unlikely to play a major role in high myopia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[137 patients with primary open angle glaucoma (67 patients with high-tension glaucoma (HTG), 70 patients with normal-tension glaucoma (NTG)) and 75 controls from the North East of England were studied.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We observed a strong association between breast cancer occurrence and the genotypes C/C of the RAD51-135G/C polymorphism, Ser/Ser of the OGG1-Ser326Cys and Lys/Gln of the XPD-Lys751Gln, whereas the genotypes G/C of the RAD51-135G/C and Lys/Lys of the XPD-Lys751Gln exerted a protective effect against breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[, our data suggest that Thai women with a certain XRCC1 diplotype or homozygous for two or three variant alleles of XRCC1, OGG1, and APEX1 are likely to have an increased susceptibility to breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[, the variant c.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphism in ornithine decarboxylase and risk of breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variants of the melanocortin 1 receptor gene (MC1R) and P gene as indicators of the population origin of an individual.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study supports an underlying polygenic response to interferon beta treatment in MS and highlights the importance of the glutamatergic system in patient response to interferon beta therapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These novel genetic findings provide new insights in relation to the mechanisms that might be involved in the development of vitiligo vulgaris.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thirty-three tagging NTRK-3 single nucleotide polymorphisms (SNPs) were genotyped in 839 schizophrenia patients and 1473 healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association study of bipolar disorder in European American and African American individuals.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[NTRK1 c.1810C>T polymorphism appears to be a new independent prognostic factor of poor outcome in neuroblastoma, especially in children under 18 months of age with no MYCN amplification.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We also provide further evidence for some smaller, previously reported, schizophrenia-associated CNVs, such as those in NRXN1 and APBA2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[NRG1 gene in recurrent major depression: no association in a large-scale case-control association study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It is our hypothesis following the melanoma model that mutations in BRAF or NRAS may play a role in wild-type GIST pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of HPA axis genes with suicidal behaviour in schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of the glucocorticoid receptor gene and major depression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional glucocorticoid receptor gene variants do not underlie the high variability of 17-hydroxyprogesterone screening values in healthy newborns.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: effects on bone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The Gly56Arg mutation in NR2E3 accounts for 1-2% of autosomal dominant retinitis pigmentosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PER2 variantion is associated with depression vulnerability.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of our study was to investigate the association between REV-ERBalpha gene (NR1D1) single nucleotide polymorphisms (SNPs) and bipolar disorder (BP) in a case-control sample of Sardinian ancestry and evaluate its effect on age at onset (AAO) of BP.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of variants in DNA damage signalling genes in bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Description and validation of high-throughput simultaneous genotyping and mutation scanning by high-resolution melting curve analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study indicates interesting new candidate genes and functional pathways for further study and confirms earlier findings.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We hypothesized that the corin I555(P568) allele would be associated with adverse outcomes and impaired BNP processing in blacks with systolic heart failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Determination of NPM1 mutation status has become essential for the molecular classification of acute myeloid leukemias (AML).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Nucleophosmin (NPM1) mutations occur frequently in adult cytogenetically normal acute myeloid leukemia (CN-AML) and confer favorable outcome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate the association of the polymorphism of NPHS1, coding gene of nephrin, with the degree of proteinuria, renal function, and prognosis of IgA nephropathy (IgAN) in patients in north China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In two large, independent populations, ABO blood type was statistically significantly associated with the risk of pancreatic cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our finding may contribute to understanding of the pathophysiology of AIP as well as to a priori identification of patients vulnerable for development of AIP.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Adding SNPs previously associated with fasting glucose, insulin, lipids or obesity to a genetic risk score for type 2 diabetes significantly increases the power to discriminate between people with and without clinically manifest type 2 diabetes compared with a model including only conventional type 2 diabetes loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Metabolic markers, but not genotyping for 20 diabetogenic SNPs, improve discrimination of incident type 2 diabetes beyond lifestyle risk factors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[NOTCH2 mutations in marginal zone lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of nitric oxide synthase gene intron 4 and exon 7 polymorphisms in obstructive sleep apnea syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The G894T polymorphism of eNOS gene is associated with pulmonary hypertension of COPD in a Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this COPD cohort we confirm that PH is frequent and usually mild, but out of proportion in a subgroup.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The endothelial nitric oxide synthase Glu298Asp polymorphism is not a risk factor for endometriosis in south Indian women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationships between endothelial nitric oxide synthase gene polymorphisms and osteoporosis in postmenopausal women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings suggest that there are at least 2 pathways in the pathogenesis of severe PIH.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interactions were observed between NOS3 SNPs and female sex and postmenopausal hormone use in the women in relation to HTPOAG.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Endothelial nitric oxide synthase and nicotinamide adenosine dinucleotide phosphate oxidase p22phox gene (C242T) polymorphisms and systemic lupus erythematosus in a Chinese Population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this work we investigated about the presence of a correlation between a (CA)n repeat located in exon 29 of NOS1 gene and the beta-thalassemia trait in Corsica Island (France).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Microarray analysis of multiple candidate genes and associated plasma proteins for nephropathy secondary to type 2 diabetes among Chinese individuals.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study suggests that common genetic variants in the OR10J3 and FCER1A be strongly associated with breast cancer risk among Korean women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Identification and association analysis of single nucleotide polymorphisms in the human noggin (NOG) gene and osteoporosis phenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No association was found between infant NNMT gene variants and risk for spina bifida in our study population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association analysis among polymorphisms of the various genes and chronic alcoholic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, we evaluated the risks of OC associated with common germline variants in five oncogenes (BRAF, ERBB2, KRAS, NMI and PIK3CA) known to be involved in OC development.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variants encoding lower activity of NOS3 may affect outcomes in breast cancer patients, with the direction of risk differing depending on chemotherapy status.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SNPs located at the gene HUS1 are good candidates for further investigation in independent association studies and functional assays.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increasing evidence suggests a role for nerve growth factor (NGFB), brain-derived neurotrophic factor (BDNF), and their receptors, nerve growth factor receptor (NGFR), and neurotrophin tyrosine kinase receptors 1 and 2 (NTRK1 and NTRK2), in Alzheimer's disease (AD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Considering the number of single-SNP tests performed and null gene-level results, we conclude that NFKBIA and NFKBIB are not likely to harbor ovarian cancer risk alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of inflammation gene polymorphisms on pain severity in lung cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Although the polymorphisms at NFKB1, FAS-1377, and extended haplotype FAS-1377G/-670G may play a role in the development of silicosis in the Chinese population, our findings should be verified by larger studies with >1 case/control ratio.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This result may indicate that the effect of interferon-alpha treatment is dependent on the availability of nuclear factor-kappaB and the polymorphism in NFKB1 may, therefore, be a good prognostic marker for multiple myeloma patients on maintenance treatment with interferon-alpha after high-dose therapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that the NFKB1 promoter polymorphism is a useful marker for the identification of patients with superficial bladder cancer where the risk of recurrence is high.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Since the presence of the rs2304052 C allele is associated with an increased risk (odds ratio: 2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We systematically investigated the association of 48 SNPS in four vitamin D metabolizing genes CYP27A1, GC, CYP27B1 and CYP24A1 with serum 25-hydroxyvitamin D 25(OH)D and 1,25-dihydroxyvitamin D 1,25(OH)(2)D levels and the association of these SNPS and an additional 164 SNPS in eight downstream mediators of vitamin D signaling VDR, RXRA, RXRB, PPAR, NCOA1, NCOA2, NCOA3 and SMAD3 with prostate cancer risk in the 749 incident prostate cancer cases and 781 controls of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the risk of cervical cancer is increased in passive smokers and in users of oral contraceptives with certain NBS1 genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Heterozygous carriers of the I171V mutation of the NBS1 gene have a significantly increased risk of solid malignant tumours.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of polymorphisms in genes of the homologous recombination DNA repair pathway and thyroid cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Molecular-genetic analysis of natural and stimulated ovulation impairment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The effect of polymorphism of genes of xenobiotics detoxication on the frequencies of spontaneous and induced chromosome aberrations in human lymphocytes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study investigated the contribution of MYOC and OPTN coding variants in Hispanics of Mexican descent with and without POAG.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Little evidence for association of the glaucoma gene MYOC with open-angle glaucoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The 2 alleles of the MYOC.mt1 promoter polymorphism were equally distributed among patients with POAG and healthy control subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association pattern between the genes, MYOC, OPTN, WDR36, and APOE, and POAG in northern Chinese is different from that of southern Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our methodology allowed to statistically measure the association of a panel of SNPs with a specific phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results indicate that Arg206 and Thr381 residues in the motor head region of MYO7A protein are critical sites and the mutations of these residues may lead to the development of nonsyndromic deafness.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ABL single nucleotide polymorphisms may masquerade as BCR-ABL mutations associated with resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study shows that familial disease is common among infants and children with HCM and that, in most cases, disease is caused by mutations in cardiac sarcomere protein genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We searched for mutations in MYH9 exons 1, 16, 26, and 30 in a total of 157 Japanese patients with nonsyndromic deafness without known cause of hearing loss, but no mutations were found.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Little evidence for a role of somatic MYH11 mutations in the formation of breast or prostate cancers was obtained in this study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results demonstrate a clear association between polymorphisms in the IRAK4 gene and serum IgE levels in patients with CRS and asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MYH7 mutations, especially in the global region, cause malignant clinical phenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The conclusion is the missense MYBPC3 mutation E334K destabilizes its protein through UPS and may contribute to cardiac dysfunction in HCM through impairment of the ubiquitin-proteasome system.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Overall, 25 of 47 (53%) patients had myofilament-HCM, including 12 with MYBPC3-HCM and 9 with MYH7-HCM.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MYBPC3 mutation is presented in a small portion of Han Chinese patients with HCM.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Carriers of the MYH Y165C or G382D mutant alleles do not appear to be at increased risk for breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pooled data from two population-based studies (1,457 cases and 1,351 controls) were analyzed to examine associations between 28 single-nucleotide polymorphisms (SNPs) in nine DNA repair genes (APEX1, BRCA2, ERCC2, ERCC4, MGMT, MUTYH, OGG1, XPC, and XRCC1) and prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Independent pharmacogenomic determinants associated with treatment outcome were identified in subsets of Taiwanese ALL patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the folate/Hcy pathway are associated with tHcy and folate derivative levels. In African American and Caucasian women, different factors are associated with folate/Hcy phenotypes and may contribute to race-specific differences in the risks of a range of pregnancy-related pathologies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, we determined total plasma homocysteine levels and MTRR A66G polymorphism in 114 patients with vascular disease: 58 patients with deep-vein thrombosis, 56 patients with arterial thrombosis, and 95 healthy subjects from the Sicilian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hyperhomocysteinemia, C677T MTHFR and C1561T GCPII are risk factors for CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequencies of MTRR 66A allele (12.7 vs. 21.0%) and SHMT 1420T allele (27.9 vs. 45.3%) were lower in autistic group compared with nonautistic group with odds ratios 0.55 (95% CI: 0.35-0.86) and 0.44 (95% CI: 0.31-0.62), respectively, indicating reduced risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High-throughput multiplex single-nucleotide polymorphism (SNP) analysis in genes involved in methionine metabolism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The relationship between homocysteine and genes of folate-related enzymes in migraine patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Long-term follow-up is needed to test associations with metastases and mortality, and the observed genetic effects require replication.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the polymorphism MTHFR C677T is clearly related to prostatic carcinogenesis, on the contrary to the other polymorphisms studied, although the MTR 2756 allele C acts as a factor of tumor aggressiveness, this being found in tumors with high carcinogenic potential.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Contrary to numerous suggestions in various publications, we did not confirm the correlation between MTHFR 677C>T polymorphism and the influence on the risk of ovarian cancer in BRCA1 mutation carriers in the investigated group of Polish women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Several studies have reported a reduced risk of developing ALL in children with MTHFR polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genetics of carotid dissection: meta-analysis of a MTHFR/C677T common molecular variant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Rapid multiplexed genotyping for hereditary thrombophilia by SELDI-TOF mass spectrometry.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the Pronto ThromboRisk kit allows fast, precise, and reliable testing for the three genetic mutations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thrombophilia is associated with increased risks of VTE in women taking oral oestrogen preparations and patients undergoing major elective orthopaedic surgery, and of VTE and adverse pregnancy outcomes in women with thrombophilia during pregnancy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy in females.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The clinical importance of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the 5-fluoropyrimidine-based therapy of metastatic colorectal tumours.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Of six polymorphisms (677C>T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95% CI 1.07-3.32 (chi2 p = 0.038).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present study provides data on the folate, cobalamin, and homocysteine status of Spanish adolescents.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data show for the first time in humans that choline itself is a source of methyl groups for de novo PtdCho biosynthesis and indicate that the MTHFR 677TT genotype favors the use of choline as a methyl donor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[One may consider that a differential response of homocysteine to folic acid supplementation may depend on MTHFR genotype which may have important implications when attempting to lower homocysteine concentrations in populations with mild folate deficiency.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Folate intake at RDA levels is inadequate for Mexican American men with the methylenetetrahydrofolate reductase 677TT genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Caucasian patients (n = 255) treated at two German hospitals for intracranial aneurysms and local controls (n = 348) were genotyped for the following polymorphisms: methionine synthase (MTR) c.2756A-->G, methylenetetrahydrofolate reductase (MTHFR) c.677C-->T, MTHFR c.1298A-->C, cystathionine beta-synthase (CBS) c.844_855ins68, CBS c.833T-->C, dihydrofolate reductase (DHFR) c.594 + 59del19bp, glutathione S-transferase Omega-1 (GSTO1) c.428C-->A, reduced folate carrier 1 (RFC1) c.80G-->A and transcobalamin 2 (Tc2) c.776C-->G.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We also carried out a systematic review and meta-analysis of all published studies which have looked at the association between MTHFR C677T genotype and depression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The A6986G polymorphism of CYP3A5, which is involved in the metabolism of vinblastine and doxorubicin, might be a genetic predictor of the severity of leukocytopenia induced by chemotherapy with methotrexate, vinblastine, doxorubicin and cisplatin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The T allele frequency and homozygous genotype of MTHFR in ESRD patients were 14% and 2.4%, respectively compared to 13.4% and 0%, respectively in the control group.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We studied the contribution of these genes to migraine susceptibility by genotyping six MTHFR and 26 ESR1 polymorphisms in 898 unrelated migraine with aura (MA) patients and in 900 unrelated healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Therefore, a cross-sectional study was conducted to investigate the association of homocysteinemia with MS components; folate and cobalamin biochemical and dietary indices of nutritional status; and genetic, anthropometric, and lifestyle factors in Brazilian subjects with MS. Waist circumference; body fat; body mass index; insulin resistance; lipid profiles; glycemia; uricemia; insulinemia; erythrocyte folate and plasma homocysteine; folate and cobalamin concentrations; C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene; coffee and alcohol intake; and smoking were determined in 63 subjects (24 males and 39 females) with MS. No difference in homocysteine plasma was observed between sexes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Methylenetetrahydrofolate reductase and spina bifida: evaluation of level of defect and maternal genotypic risk in Hispanics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The analysis of the relationship between A1298C and C677T polymorphisms of the MTHFR gene with prostate cancer in Eskisehir population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[No evidence of an association of MTHFR A1298C polymorphism with prostate cancer was found.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These data suggest that all three MTHFR polymorphisms may play a pivotal role in the developing prostate cancer. Larger studies in different ethnic populations and incorporating dietary folate intake are needed to replicate our findings.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A total of 138 children diagnosed as autistic based on Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria and Autism Behavior Checklist scoring and 138 age and sex matched children who are nonautistic were tested for five genetic polymorphisms, that is, cytosolic serine hydroxyl methyl transferase (SHMT1 C1420T), methylene tetrahydrofolate reductase (MTHFR C677T and MTHFR A1298C), methionine synthase reductase (MTRR A66G), methionine synthase (MS A2756G) using PCR-restriction fragment length polymorphism methods.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MTHFR C677T is not a risk factor for autism spectrum disorders in South Brazil.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These findings suggest that in obese subjects, Hcy cycle efficiency is impaired by MTHFR, MTR, and MTRR inability to supply methyl-group donors, providing evidence that MTHFR, MTR, and MTRR gene polymorphisms are genetic risk factors for obesity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Applicability of allele/genotype frequency from documented controls for case-control studies on genotypes among Japanese: MTHFR C677T as an example.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Clinical (sex, age, type of MS, relapse, disease duration, coexisting disease, smoking habit, and physical disability) and laboratory variables (HHcy, low serum levels of folate and vit.B12, MTHFR genotype) were evaluated for their ability to predict cognitive impairment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ETV6-RUNX1 fusion gene and additional genetic changes in infant leukemia: a genome-wide analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Single nucleotide polymorphism in ABCG2 is associated with irinotecan-induced severe myelosuppression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Although, on the whole, the frequency distributions among the Portuguese fitted the patterns commonly found in other Europeans well, evidence for some degree of African influence was observed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[This study provides a platform to evaluate pharmacogenetic predictors of response or severe adverse events in advanced CRC. Pharmacogenetic studies can be conducted in multicenter trials, and our findings demonstrate that with continued research, clinical application is practical.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Reportedly, the c.421C > A ABCG2 gene polymorphism was associated with gefitinib-induced diarrhea in Caucasian patients with non-small-cell lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[this work points towards MSRA as a novel schizophrenia candidate gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association of rare MSH6 variants with familial breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The independent risk conferred by genetic variants encoding pathways such as inflammation and lipid metabolism, not adequately reflected by conventional biomarkers, may identify high-risk individuals for intensified control of modifiable risk factors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Mutation or polymorphism of the CD20 gene is not associated with the response to R-CHOP in diffuse large B cell lymphoma patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These results suggest that FCER1A variants by themselves and in combination influence IgE levels and act synergistically to influence eczema risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MPLW515L point mutation in patients with myeloproliferative disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MPL W515L mutation and JAK2 exon 12 mutations can also be found in JAK2 V617F negative MPN patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA-class I markers and multiple sclerosis susceptibility in the Italian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Single nucleotide polymorphism (SNP) mapping was performed on an 865-kb candidate region (D6S1683-D6S265) in 166 Tasmanian MS families, and seven candidate genes ubiquitin D (UBD), olfactory receptor 2H3 (OR2H3), gamma-aminobutyric acid B receptor 1 (GABBR1), myelin oligodendrocyte glycoprotein (MOG), HLA-F, HLA complex group 4 (HCG4) and HLA-G were resequenced.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genotypes in matrix metalloproteinase 9 are a risk factor for COPD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We have studied the association between the -1562 C/T polymorphism of the MMP-9 gene and the risk of sporadic ALS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genetic variants account for interindividual differences in disc matrix synthesis and degradation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Several SNPs and haplotypes in the matrix metalloproteinase-3 (MMP3) and MMP9 genes and in the vitamin C receptor genes, solute carrier family 23 member 1 (SLC23A1) and SLC23A2, showed associations with NHL risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We tested the hypothesis that polymorphic variation in MMP genes influences the risk of developing COPD by examining functional polymorphisms in the promoters of MMP-3, MMP-9 and MMP-12 genes in 111 COPD patients and 101 controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[This large prospective cohort study provides evidence that SNPs of genes encoding prototypical inflammatory molecules may be used to create multigenic models that predict stroke risk in subjects with type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Stromelysin-1 polymorphism as a new potential risk factor in progression of chronic obstructive pulmonary disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genetic variation within the MMP2 promoter region was associated with cap thickness and therefore may influence the role of MMP2 in plaque vulnerability.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[This study suggests that the polymorphism in MMP8 is associated with a decreased lung cancer risk, which can be used as a prognostic marker in lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Our studies have shown that the genotype and allele frequencies of polymorphisms G(-1607)GG of MMPI gene, C(-1562)T of MMP9 gene and A(-82)G of MMP12 gene do not significantly differ in the samples of chronic obstructive pulmonary disease (COPD) patients (N = 318) and healthy controls (N = 319) dwelling in Bashkortostan Republic.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association of MMP1, MMP3, MMP9, and MMP12 polymorphisms with risk and clinical course of multiple sclerosis in a Polish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association between promoter -1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The MMP1-1607dupG and MMP3-1171dupA promoter polymorphisms are not valuable markers of susceptibility for varicose veins.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We examined associations between 44 variants that tag the known common variants (minor allele frequency 0.05) in seven MMR genes (MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2) and survival of invasive ovarian cancer patients in three case-control studies from United Kingdom (UK), Denmark and California of United States of America (USA).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Racial differences in MLH1 and MSH2 mutation: an analysis of yellow race and white race based on the InSiGHT database.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[I219V polymorphism in hMLH1 could influence the clinical course of the disease and lead to resistance to therapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Common variants in human CRC genes as low-risk alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[, by means of our QuadMAPH assay, copy number measurement data were of sufficient resolution and accuracy to detect any copy number variants with high probability.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Associations of MICB with cervical cancer in north-eastern Thais: identification of major histocompatibility complex class I chain-related gene B motifs influencing natural killer cell activation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Further, conditional haplotype analyses demonstrated that variation within MICB (class I, rs3828903, p = 0.006) also contributes to SLE risk independent of HLA-DRB1*0301.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MICA polymorphisms and decreased expression of the MICA receptor NKG2D contribute to idiopathic pulmonary fibrosis susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Toll-like receptor signaling pathway variants and prostate cancer mortality.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[our data suggest a genetic and functional association of PBX1 with BMD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Furthermore, rs4774*C was associated with DRB1*1501+ MS when conditioned on the presence (OR = 1.67, 95% CI = 1.19-2.37, P = 1.9 x 10(-3)) and absence (OR = 1.49, 95% CI = 1.15-1.95, P = 2.3 x 10(-3)) of CLEC16A rs6498169*G, a putative MS risk allele adjacent to CIITA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Glioblastoma patients with MGMT promoter methylation showed better response to chemotherapy based on alkylating agents and longer survival than patients without MGMT methylation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The MEP1A gene, located on human chromosome 6p (mouse chromosome 17) in a susceptibility region for inflammatory bowel disease (IBD), encodes the alpha-subunit of metalloproteinase meprin A, which is expressed in the intestinal epithelium.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The results of this study suggest that MEFV gene mutations appear to be an aggravating factor for the severity of RA, and consequently, patients with RA might be screened for MEFV gene mutations in countries where FMF is frequent.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A mutation in MEF2A (myocyte enhancer factor-2A) had been reported to be the first gene linked directly to coronary artery disease (CAD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Our results also suggest that MECP2 association has no influence in the sex bias of SLE, contrary to what has been proposed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MDM2 SNP309 is associated with endometrial cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Targeting MDM2-p53 interactions might emerge as a successful treatment strategy for B-CLL.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Impact of MDM2 SNP309 genotype on progression and survival of stage 4 neuroblastoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Our study showed no association between the p53 SNP G72C and the MDM2 SNP T309G with susceptibility or course of disease in patients with WG.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The study provides evidence supporting the association of MDM2 SNP309 with high-grade osteosarcoma risk in females and shows that TP53 Arg72Pro has a prognostic value for overall survival and EFS in osteosarcoma patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[SNCA variants are associated with increased risk for multiple system atrophy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Common MCL1 polymorphisms associated with risk of tuberculosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Common genetic variation near MC4R is associated with waist circumference and insulin resistance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Greater adiposity conferred by FTO and MC4R SNPs led to higher CRP levels, with no evidence for any reverse pathway.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[To search for markers conferring genetic susceptibility to suicide, we typed six HPA axis genes (CRH, CRHR1, CRHR2, CRHBP, MC2R, NC3R1) in a cohort of 231 subjects with schizophrenia in which 81 attempted suicide.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.