[Our results argue against a major role of NF-M in PD. However, rare variants of the NF-M gene may act as susceptibility factors for PD and functional analyses of the identified variations are warranted to decipher possible mechanisms in NEUROLOGICALeneration.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

Gene-disease associations inferred from text-mining the literature.
DisGeNET evidence - LITERATURE

[Taking into account the above results, as well as those of other studies, it appears that the ND gene mutations can account for 3% of cases of advanced ROP. Although the ND gene is not frequently involved in advanced ROP, the present large-scale study further supports the hypothesis that genetic influences may play an important role in the development of severe ROP in some premature infants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Mutations in the Norrie disease gene can lead to retinal malformations of variable severity both in hemizygous males and manifesting carriers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results suggest that genetic variations in NCAM1 or nearby genes could confer risks associated with bipolar affective disorder in Japanese individuals.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[is that heterozygous germline mutation I171V in NBS1 gene is a significant risk factor for breast cancer development.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of variants in DNA damage signalling genes in bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[our study provides the strongest evidence to date for a role of common variants in DNA repair genes in bladder carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic susceptibility to distinct bladder cancer subphenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Haplotypic variation in MRE11, RAD50 and NBS1 and risk of non-Hodgkin's lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In a multicenter case-control study, 490 colorectal cancer patients and 593 controls (433 matched case-control pairs) were genotyped for common polymorphisms in the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), sulfotransferase (SULT1A1 and SULT1A2), N-acetyl transferase 2 (NAT2), NAD(P)H:quinone oxidoreductase (NQO1), methylenetetrahydrofolate reductase (MTHFR), and microsomal epoxide hydrolase (EPHX1) genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Molecular genetic analysis of NBS1 in German melanoma patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Even in presence of high alcohol consumption or cigarette smoking, a high intake of fruit and vegetables might prevent the development of around one quarter of SCCHN cases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study the role of genetically determined individual NAT1 and NAT2 genotypes, haplotypes and haplotype combinations in the predisposition to head and neck cancer was investigated.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study integrates epidemiological and clinical data as well as genetic markers along major pathogenic pathways of PTD. The findings from this study should improve our understanding of genetic influences on PTD and gene-environment interactions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The NAT2 slow acetylator phenotype/genotype has been inconsistently associated with lung cancer and, to date, the role of NAT1 polymorphism in lung cancer has not been reported.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lung cancer susceptibility model based on age, family history and genetic variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of this study was to determine the existence of association between the genetic polymorphisms of metabolizing genes GSTM-1, GSTT-1, and NAT-2, and the presence of mitochondrial genome instability (mtGI) in breast cancer cases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meat consumption, heterocyclic amines, NAT2, and the risk of breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The distribution of NAT2 activity in the healthy control group was found to be correlated with that of healthy caucasians. Patients had slow acetylator phenotypes of NAT2, 1.8 times higher than controls but no statistical differences were found (p=0.07). In addition, the NAT2*5 alelle was more statistically correlated with breast cancer patients rather than the controls (p=0.02). Moreover, NAT2*5B was the most frequent haplotype of the NAT2*5 family (p=0.000). Breast cancer patients were detected to posses more CYP1B1*3 mutant alleles than the controls (p=0.043). The combined effect of CYP1B1*3 polymorphism and NAT2 slow acetylator genotype contributed to an increased risk for breast cancer in patients in this study (p=0.004).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Statistically significant increases in asthma risk were also observed among the whole study population for the concurrent presence of the GSTM1 null genotype and either NAT1 (odds ratio OR 4.53, 95% CI 1.76 to 11.6) or NAT2 (OR 3.12, 95% CI 1.11 to 8.78) slow acetylator genotypes, and of NAT1 and NAT2 slow acetylator genotypes (OR 4.20, 95% CI 1.51 to 11.6).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study shows an association between acetylation polymorphism and susceptibility to extrinsic asthma, but not to intrinsic asthma, suggesting a minor role of the NAT2 polymorphism in the development of atopic asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Individuals with NAT2 slow acetylator genotypes had a significant increase in risk of BC compared to individuals with NAT2 rapid acetylators (OR adjusted for smoking status=2.70; 95% CI, 1.10-6.61).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphysms of the three genes encoding phase 1 (CYP1A1, mEPH1, and CYP2E2) and the three genes encoding phase 2 (NAT2, GSTM1, and GSTT1) xenobiotic detoxication enzymes were typed by use of PCR in 74 patients with extragenital endometriosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that the two polymorphisms, GSTT1 null and PON1 BB, are common genetic traits that pose low individual risk but may be important determinants of overall population NHL risk, particularly among groups exposed to NHL-related carcinogens.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We examine whether there was a correlation between diplotype configurations (combinations of 2 haplotypes for a subject) at the NAT2 gene and the adverse effects of SSZ used for the treatment of rheumatoid arthritis (RA).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In a preliminary report we demonstrated an association between the slow acetylator genotype of N-acetyltransferase 2 (NAT2) and familial cases of Parkinson's disease (FPD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For tumor protein 53 (TP53), N-acetyl transferase 1 (NAT1), NAT2, glutathione-S transferase Mu (GSTM1), glutathione-S transferase Theta (GSTT1), and glutathione-S transferase Pi (GSTP1) polymorphisms, the best estimates are sufficient to exclude a 1.7-fold increase in risk of colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene-environment interactions in pancreatic cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No significant correlation was found between the level of 8-OH-dG and the MnSOD, GSTM1, and hOGG1 polymorphisms. However, one novel polymorphism/mutation of the hOGG1 gene was found in a pancreatic tumor. Mutation at codon 12 of the K-ras gene was found in 25 (81%) of 31 pancreatic tumors, including three G-to-A transitions and 22 G-to-T transversions. Patients with the G-to-T mutation had a significantly higher level of aromatic DNA adducts than those with G-to-A or wild-type codon (P=0.02). On the other hand, the K-ras mutation profile was not related to the level of 8-OH-dG. Given the limitation of sample size, these preliminary data lend further support the hypothesis that carcinogen exposure and oxidative stress are involved in pancreatic carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The associations between the genotypes of glutathione S-transferase (GST) M1, GSTP1, GSTT1 and N-acetyltransferase (NAT) 1 and the phenotypes of NAT2 and cytochrome P450 (CYP) 1A2 and bladder cancer risk were examined in a case-control study involving 731 bladder cancer patients and 740 control subjects in Los Angeles County, California.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[our findings suggest a very limited role, if any, of genetic polymorphisms investigated in modulating the BC risk in coffee drinkers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that CYP1A1*4, NAT1 and NAT2 variants are involved in the susceptibility to breast carcinoma by modifying the impact of exogenous and/or endogenous exposures.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Overall, there is no conclusive evidence that genetic variants in genes involved in the estrogen metabolic pathway are associated with mammographic density in postmenopausal women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Results of exploratory analyses of the data suggest that the association of PCA and MnSOD exists only in the subpopulation of rapid NAT1 genotypes and smokers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Based on these observations, a screening strategy of MYOC mutations in French POAG patients is briefly outlined.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The absence of the POAG-associated Q368X mutation and the presence of particular polymorphisms, including P13P + L159L and T325T, could be specific features of the MYOC sequence in African populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The GLC1A Thr377Met mutation is associated with POAG that, in the pedigrees studied, had a younger age at onset and higher peak intraocular pressure than in pedigrees with the more common Gln368STOP mutation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings indicate that the mutation frequency of the MYOC gene is 2% in the Indian population affected with POAG, which is not a well-studied ethnic group of the Asian continent.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in MYL2 could be associated with both benign and malignant HCM phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated 100 independent patients with HCM (proband 51, sporadic 49) by sequencing the three most frequent HCM-causing genes (MYH7, MYBPC3, TNNT2).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic screening of the beta-myosin heavy chain gene (MYH7) was evaluated in 100 consecutive unrelated patients with hypertrophic cardiomyopathy (HCM) and 200 normal unrelated subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[left ventricular noncompaction is within the diverse spectrum of cardiac morphologies triggered by sarcomere protein gene defects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The breast cancer risk associated with this genotype increases above the age of 50 years (OR = 2.24, 95% CI 1.20-4.21, p = 0.012). The wild-type amino acid Asn of this polymorphism is located in the N-terminal MYC transactivation domain and is highly conserved not only among most diverse species but also in the N-MYC homologue. Due to the pivotal role of c-MYC in diverse tumours, this variant might affect the genetic susceptibility of other cancers as well.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Further work is recommended to understand the potential functional role of these specific non-synonymous amino acid changes and a larger, more comprehensive investigation of genetic variation in these genes (e.g., using a tagSNP approach) in combination with other relevant genes is needed as well as consideration for treatment effects when assessing their po]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ This study defines the frequency and associated phenotype for MYBPC3 and/or multiple mutations in HCM in the largest cohort to date. In this cohort, unrelated patients with MYBPC3-HCM virtually mimicked the phenotype of those with mutations in the beta-myosin heavy chain. Patients with multiple mutations had the most severe phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ MxA promoter -88 G/T SNP may confer host genetic susceptibility to SSPE in Japanese individuals. The finding that homozygotes of the MxA -88T allele with a high MxA-producing capability were more frequently seen in SSPE patients suggests that the MxA protein promotes the establishment of persistent MV infection of neural cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Approximately 69% of the excess familial risk in FDRs can be ascribed to MSS CRC, and although the pattern of familial risk supports recessive susceptibility in addition to MUTYH, the absolute risk of CRC is at best modest.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results reveal that MYH accounts for 16 percent of polyposis patients without germline mutations in the APC gene and that it does not appear to be a modifier gene in FAP patients diagnosed with APC germline mutations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data extend the association of MUC7*5 allelic polymorphisms and asthma to inner-city African Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MTRR polymorphism interacted with the association of folate (P for interaction = 0.04) or vitamin (P for interaction = 0.02) with colorectal cancer, although the other polymorphisms did not interact with any nutrient intake.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This population-based case-control study was designed to investigate the interrelationships between polymorphisms in the methylenetetrahydrofolate (MTHFR C677T and A1298C) gene and other genes (MTR A2756G; MTRR A66G and CBS 844ins68), intake of B-vitamins and colorectal cancer risk (CRC).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results are consistent with accepted paradigms and offer a plausible explanation for the effect and interaction of specific SNPs in the TE phenotype. The biological implications of the limited number of MTHFR/MTHFR mutant alleles that can coexist, u]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In a case-control study, we evaluated whether four common polymorphisms in methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A2756G), and methionine synthase reductase (MTRR A66G) genes may have a role in altering susceptibility to adult acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The double heterozygosity MTR 2756 AG/MTRR 66 AG was the single combined genotype that was a significant risk factor for having a DS child, with an OR estimated at 5.0 (95% CI: 1.1-24.1), after adjustment for t-Hcys.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Recent evidence has suggested that 5,10-methylenetetrahydrofolate reductase (MTHFR) and/or methionine synthase reductase (MTRR) might contribute to the maternal risk of trisomy 21.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[As regards the MTRR A66G polymorphism, the presence of the mutated G allele either in the heterozygous or homozygous form was significantly more common among mothers of children with DS than among control subjects (odds ratio, 2.21; 95% CI, 1.11-4.40).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The increased risk of DS for homozygous RFC-1 80G>A was not associated with MTR 2756A>G. Positive interactions were found for the following genotype-pairs: MTHFR(CT+TT)/MTRR GG, MTHFR (CT+TT)/RFC-1 AA, MTHFR CC/MTR(AG+GG), MTHFR (CT+TT)/MTR AA, MTRR GG/MTR AA, and RFC-1 AA/MTRAA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationship between polymorphisms in genes involved in homocysteine metabolism and maternal risk for Down syndrome in Brazil.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Genetic variation in the MTP promoter is likely to be highly involved in the production of dyslipidemia in type 2 diabetic subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The polymorphism of MTNR1B located in 3'-untranslated region (rs 1562444) was selected for its higher rate of heterozygosity among other single nucleotide polymorphisms (SNPs) in both MTNR1A and MTNR1B genes and investigated in RA patients (n = 173) and healthy controls (n = 195) by polymerase chain reaction-restriction fragment length polymorphism assay using NlaIII restriction enzyme.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that the pathogenetic role of the MTHFR T677 allele in migraine is modulated by functional polymorphisms of TS and MTHFD1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The MTHFD1 R653Q, SLC19A1 R27H, and TCN2 P259R polymorphisms showed no significant association with omphalocele.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, polymorphisms in the folate-related genes MTHFR, MTRR, and SHMT1 are related to MTX resistance in pediatric ALL patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that women who are 'QQ' homozygote for the MTHFD1 1258G --> A (R653Q) polymorphism are almost three times more likely to develop severe abruptio placentae during their pregnancy than women who are 'RQ' or 'RR.']. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Joint effects of inflammation and androgen metabolism on prostate cancer severity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We genotyped 929 CRC patients and 1098 control subjects from Ontario, and 467 patients and 344 controls from Newfoundland and Labrador, for two promoter polymorphisms in the MMR genes MSH2 and MSH6 using the fluorogenic 5' nuclease assay.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single nucleotide polymorphism analysis of germline MSH6 gene mutations in Chinese hereditary non-polyposis colorectal cancer probands.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Screening for germline mutations of MLH1, MSH2, MSH6 and PMS2 genes in Slovenian colorectal cancer patients: implications for a population specific detection strategy of Lynch syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Median age at diagnosis of first CRC in MSH6 mutation families was 59 years compared to 45 years in both MLH1 and MSH2 mutation families.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic investigation of DNA repair genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1, as possible susceptibility factors for sporadic CRC, was done using both a haplotype tagging and a candidate (i.e.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[in central Ohio, at least 1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that the polymorphism may be associated with an increased risk to develop NHL and that probably there are differences in the effect of the polymorphisms among populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results demonstrate ethnic differences in polymorphisms of atopy candidate genes. Additional studies involving larger samples are required to investigate the association between asthma or atopy and the genotypes studied to date in Chinese children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These results show the FcgammaRIIa-R131 allele to be associated with periodontitis risk in SLE patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ This study supports the notion that polymorphisms in the Fc epsilon R1-beta gene have significant effects on IgE responsiveness. Secondly, dust mites in rural populations influence the expression of genes on chromosome 11q13.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our findings suggest that promoter polymorphisms of both CTLA4 and FCER1B are genetic factors that influence total serum IgE levels in patients with asthma. This supports the theory that variance in total serum IgE levels in patients with asthma is determined by mutations in multiple genes, each of which has a relatively small effect on the phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[An axonal form of Charcot-Marie-Tooth disease showing distinctive features in association with mutations in the peripheral myelin protein zero gene (Thr124Met or Asp75Val).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common genetic variants in the interleukin-6 and chitotriosidase genes are associated with the risk for serious infection in children undergoing therapy for acute myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A polymorphism in the promoter region of myeloperoxidase (463G-->A) has been found to be inversely associated with lung cancer; differences in the association with age and gender have been suggested.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated the prognostic significance of genetic polymorphism in glutathione-S transferase mu 1 (GSTM1), glutathione-S transferase theta 1 (GSTT1), NAD(P)H:quinone oxidoreductase (NQO1) and myeloperoxidase (MPO), the products of which are associated with drug metabolism as well as with detoxication, in 193 patients with de novo acute myeloid leukemia (AML) other than M3.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that individual susceptibility of bladder cancer may be modulated by MPO and MnSOD polymorphisms, and that the combination of genetic factors involved in oxidative stress response with environmental carcinogens may play an important role in bladder carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Neither the MPO mutation nor specific genotypes of cytochrome P4502D6 were associated with CA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data indicate that gene variants that impact oxidative stress modify prognosis after treatment for breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[from this study suggest that exogenous and endogenous modulators of oxidative stress may modify the association between the MPO polymorphism and breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We assessed 27 selected polymorphisms based on previously described associations or putative functional effects in 16 key genes from pathways that may influence cellular sensitivity to taxanes (ABCB1, ABCC1, ABCC2, ABCG2, CDKN1A, CYP1B1, CYP2C8, CYP3A4, CYP3A5, MAPT, and TP53) and platinum (ABCC2, ABCG2, ERCC1, ERCC2, GSTP1, MPO, and XRCC1) using polymerase chain reaction and Pyrosequencing in 914 ovarian cancer patients from the Scottish Randomised Trial in Ovarian Cancer phase III trial who were treated at presentation with carboplatin and taxane regimens after cytoreductive surgery.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[have been difficult to draw and are partly hampered by the small number of patients in each study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, genetic polymorphisms may be associated with subsequent myocardial infarction, and may also be associated with treatment-associated bleeding among coronary patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, our study in a large series of angiographically defined patients suggests that the C-1562T polymorphism may not be useful as a predictor of the presence and severity of coronary atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No significant difference between controls and ACS patients was found in the frequencies of MMP-9 C-1562T and G5564A, Fib Bbeta-148C/T and GPVI T13254C genotypes and alleles (P > 0.05).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present findings suggest that the genetic polymorphism in MMP-9 promoter (C-1562-T) is associated with the susceptibility to ACS in the Han population of China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results show that functional genetic variation of stromelysin-1 could be a significant risk factor for stable angina, and might play an important role in coronary atherosclerosis involving vascular remodeling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results indicate that the T allele in the MMP-9 promoter is associated with the invasive phenotype of gastric cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In a prospective study of 1127 patients with documented coronary artery disease, we measured baseline plasma MMP-9 levels and determined the MMP-9/C-1562T and MMP-9/R279Q genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Matrix metalloproteinase-9 (MMP-9) plays an important role in the pathogenesis of atherosclerosis, the pathology underlying the majority of coronary artery disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MMP-9 microsatellite polymorphism: association with the progression of intima-media thickening and constrictive remodeling of carotid atherosclerotic plaques.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[this study identified SNPs in MMP1, MMP2, MMP7 and MMP12 for further investigation as possible predictors of chemotherapy outcome in lung cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Finally, we claim that determination of MMP-9 enzyme levels and expression of MMP-2 and -9 and TIMP-1 can be used as a marker in lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that there are cell host-dependent differences in MMP-9 promoter activity related to CA-repeat number and that fetal carriage of the 14 CA-repeat allele is associated with PPROM in African Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, the microsatellite polymorphism upstream of the MMP-9 gene could be a useful genetic marker for diabetic nephropathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that the polymorphism of MMP-9 acts as a genetic factor for the development of smoking-induced pulmonary emphysema.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The use of DNA pooling technology increased the throughput and decreased the cost of our association analysis of nephropathy in our type 2 diabetes sample, which demonstrated sufficient sensitivity to support previous positive findings of association with a microsatellite in the MMP9 promoter region.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Accumulation of gene polymorphisms related to plaque rupture and thrombus formation is likely associated with the prevalence of cerebral infarction in type 2 diabetic patients, suggesting that the combined information about these variants is useful to ass]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results imply that susceptibility to OSF could involve multigenic mechanisms modified by the betel quid-exposure dose]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The study suggested that a possible association between the MMP-7 A/G polymorphism with susceptibility to epithelium ovarian cancer, but there is no support for an association of the selected MMP-1 1G/2G, MMP-3 5A/6A, and MMP-9 C/T polymorphisms with the risk for ovarian cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These findings suggest that genetic variations in TIMP1, TIMP3, MMP10, and ELN genes may contribute to the pathogenesis of AAAs. Further work is needed to confirm the findings in an independent set of samples and to study the functional role of these variants in AAA. It is noteworthy that contrary to a previous study, we did not find an association between the MMP9 (nt-1562) polymorphism and AAA, suggesting genetic heterogeneity of the disease. CLINICAL RELEVANCE: Abdominal aortic aneurysms (AAAs) are an important cardiovascular disease, but the genetic and environmental risk factors, which contribute to individual's risk to develop an aneurysm, are poorly understood. Histologically, AAAs are characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. We hypothesized that genes involved in these events could harbor changes that make individuals more susceptible to developing aneurysms. This study identified significant genetic associations between DNA sequence changes in tissue inhibitor of metalloproteinase 1 (TIMP1), TIMP3, matrix metalloproteinase 10 (MMP10) and elastin (ELN) genes, and AAA. The results will require confirmation using an independent set of samples. After replication it is possible that these sequence changes in combination with other risk factors could be used in the future to identify individuals who are at increased risk for developing an AAA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The MMP-3 5A allele is associated with the occurrence of CA. Our results suggest that an increased proteolysis in the arterial wall may act as a susceptibility factor for the development of CA in patients with coronary atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multivariate logistic regression analysis, with adjustment for age, body mass index, and the prevalence of smoking and hyperuricemia, revealed that the -219G-->T polymorphism of the apolipoprotein E gene in low-risk men, the -1171/5A-->6A polymorphism of the stromelysin-1 gene in low-risk women, the 1019C-->T polymorphism of the connexin 37 gene in high-risk men, and the 3932T-->C polymorphism of the apolipoprotein E gene in high-risk women were significantly associated with CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Stromelysin 1 (matrix metalloproteinase 3) and HLA-DRB1 gene polymorphisms: Association with severity and progression of rheumatoid arthritis in a prospective study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present result suggested that the MMP3 promoter polymorphism may modify susceptibility to NSCLC, and the MMP 1G/5A haplotype may predicate the risk of lymphatic metastasis of this tumor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that the MMP-1 promoter polymorphism may be associated with HNSCC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A multigenic approach to predict breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study provides the first evidence of an association between a polymorphism in the MMP-3 gene promoter and the severity and progression of RA, but not RA susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Synergistic effect of stromelysin-1 (matrix metallo-proteinase-3) promoter 5A/6A polymorphism with smoking on the onset of young acute myocardial infarction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of our study was to analyze the possible association of eNOS G894 T and MMP-3 5A/6A gene polymorphisms with hypertension in Serbian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our data strongly suggest that the 5A/6A polymorphism of the stromelysin-1 gene is not related to angiographic restenosis or the 1-year clinical outcome after interventions in coronary arteries.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The data indicate a key role for stromelysin in the atherosclerotic process. Men with the stromelysin genotype 5A5A represent 29% of the general population, and their high risk, if smokers, provides a further strong argument for smoking avoidance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The roles of stromelysin-1 and the gelatinase B gene polymorphism in stable angina.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have investigated the influence of a biallelic polymorphism of the promoter region of stromelysin (matrix metalloproteinase 3) on susceptibility to primary sclerosing cholangitis (PSC).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data imply the involvement of MMP3 in chronic remodelling after conventional balloon angioplasty, and suggest that the 6A6A MMP3 genotype is a genetic susceptibility factor for restenosis after angioplasty without stenting.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of the study was to investigate the effect of functional polymorphisms in promoters of matrix metalloproteinase (MMP) 2, MMP-3, MMP-9, MMP-12 and plasminogen activator inhibitor (PAI) 1 genes on the growth rate of small abdominal aortic aneurysms (AAA).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic approaches to the investigation of rheumatoid arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results are consistent with our previous findings and further support the hypothesis that gain-of-function of MMP2 resulting from genetic polymorphisms plays an important role in human carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have demonstrated that several SNPs are associated with survival.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We found that the G/G genotype in the MMP-2-1575G/A polymorphism was significantly increased in colorectal cancer patients than in the controls (odds ratio (OR), 1.96; 95% CI, 1.06-3.64).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest MMP-2 and TIMP-2 genotypes play a crucial role in gastric cancer invasion, but not with development of gastric cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This case control study was to assess the contribution of this MMP2 polymorphism to risk of development and metastasis of gastric cardia adenocarcinoma (GCA).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Two MMP-2 promoter polymorphisms (-790T/G and -735C/T) in chronic heart failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A cohort of patients with seropositive rheumatoid arthritis were recruited and genotyped for the MMP1-1607 1G > 2G, MMP3-1612 5A > 6A, MMP7-153C > T, MMP7-181G > A, MMP12-82A > G and MMP13-77A > G polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results show that patients with stage I NSCLC carrying the variant G allele of the MMP-12 1082A/G polymorphism have worse survival.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings suggest that there are haplotypes in a MMP cluster region that modify the joint destruction in RA in a phasic manner.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[By using the methods of polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP), MMP1 -1607(1G>2G) polymorphisms in 150 patients with lung cancer, and 200 healthy controls were detected to evaluate the relationship between different genotypes and susceptibility of lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study suggests that the polymorphism in MMP8 is associated with a decreased lung cancer risk, which can be used as a prognostic marker in lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study aimed to evaluate the association between the MMP-1 promoter gene polymorphism and chronic periodontitis susceptibility and/or severity in a Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The relation between matrix metalloproteinase-1 promoter genotype and remodeling was studied in 42 patients after their first acute myocardial infarctions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The purpose of this study was to investigate the possible relation of matrix metalloproteinase-1 (MMP-1) to increased risk for oral cancer, in light of recently found contribution of angiogenesis and thrombosis-related factors to the development of malignancies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The influence of interstitial collagenase-1 genotype polymorphism on colorectal cancer risk in Iranian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The genetic polymorphisms of MMP-1 are not associated with the risk of HSIL and SCC, but with the invasiveness and prognosis of SCC. The heterozygous genotype of MMP-1 can be used as a prognostic marker in patients with invasive cervical cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest that the FAS 1377G>A and IL10 592C>A polymorphisms could modify disease-free and overall survival in women with lymph node-positive breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that MMP single-nucleotide polymorphisms influence breast cancer behavior and that the MMP-1 2G/2G genotype increases the risk of lymph node metastasis and predicts poor prognosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with conventional renal cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aims of this study were to investigate (1) the matrix metalloproteinase-1 (MMP-1) promoter polymorphisms in severe chronic periodontitis (CP), (2) the relationship of periodontal therapy outcome with these genotypes, and (3) the gingival crevicular fluid (GCF) MMP-1 levels-MMP-1 genotype correlation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between neprilysin polymorphisms and sporadic Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association of IgH rearrangements with ALL-1 alterations in AML, coupled to the frequent detection in this subset of lymphoid associated markers, further supports the origin of these tumors from a common multipotent precursor with bipotential lymphoid and monocytic differentiation capability.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PTGS2 and ERCC5 were associated with stomach cancer risk in a Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Significant differences in allele frequencies between cases and controls were observed for ID3 (inhibitor of DNA binding), p = 0.05, HPN (hepsin), p = 0.009, BCAS1 (breast carcinoma amplified sequence 1), p = 0.007, CAV2 (caveolin 2), p = 0.007, EMP3 (epithelial membrane protein 3), p < 0.0001, and MLH1 (mutL homolog 1), p < 0.0001. SNPs in three of these genes (BCAS1, EMP3 and MLH1) remained significant in an age-matched subsample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Germ-line mutations in mismatch repair genes associated with prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genotype-phenotype correlations in individuals with a founder mutation in the MLH1 gene and hereditary non-polyposis colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that the hMLH1 -93G-->A polymorphism could be used as a marker of genetic susceptibility to squamous cell carcinoma of the lung.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, we investigated whether singlenucleotide polymorphisms (SNPs) in human mutS homolog 2 (hMSH2) and the human mutL homolog 1 (hMLH1) were associated with the tumor response in advanced NSCLC patients received platinum-based chemotherapy in Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of Crohn's disease and ulcerative colitis with haplotypes of the MLH1 gene in Italian inflammatory bowel disease patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To analyze the genetic contribution of HLA in development of psoriatic arthritis (PsA) and to study whether MICA is primarily associated with PsA or whether its association is secondary to linkage disequilibrium with centromeric genes, such as MICB, TNFA, or HLA-DRB1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequency of the MICA-MICB null haplotype was 3.7% on the average, and was strongly associated with HLA-B48 in seven East Asian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The allele frequency of MICA*A9 significantly decreased in RA patients compared with controls (9.0% vs. 15.3%, odds ratio OR = 0.55, p = 0.0098, p(c) = 0.049), whereas the frequency of the MICA*A4 and MICA*A5.1 alleles tended to increase in RA patients (21.2% vs. 14.8%, OR = 1.55, p = 0.018, p(c) > 0.05; 20.5% vs. 15.0%, OR = 1.46, p = 0.0403, p(c) > 0.05).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased prevalence of celiac disease without gastrointestinal symptoms in adults MICA 5.1 homozygous subjects from the Campania area.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The above-mentioned pattern, most likely formed by recombination of the telomeric fragment of the MHC 7.1 ancestral haplotype, seems to be the most important genetic determinant of susceptibility to the extensive form of UC in our population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This finding suggests that an association between MICA-A6 and BD may be a secondary phenomenon related to HLA-B51.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Allelic diversity and affinity variants of MICA are imbalanced in Spanish patients with Behet's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of the MIC-A gene and HLA-B51 with Behet's disease in Arabs and non-Ashkenazi Jews in Israel.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behet disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There are several susceptibility genes for psoriasis residing in chromosome 6p near the HLA-C locus, including the corneodesmosin (CDSN) gene, the octamer transcription factor-3 (POU5F1) gene, the major histocompatibility complex class I chain-related gene A (MICA), and the gene for tumour necrosis factor (TNF)-alpha.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that the MICA 5.1 allele might be a genetic marker related to the early onset of psoriasis and play a secondary role to the HLA-Cw*0602 gene or an unknown causative gene closely linked to HLA-Cw*0602 in the genetic susceptibility to psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A comparison of the psoriasis patients and the control group revealed that MICA*010 and MICA*017 were associated with Type I psoriasis whereas only MICA*010 was associated with Type II.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ MICA gene displayed different allele distributions in different populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Alleles of MICA gene exon 5 are conservative in all populations studied so far. The results suggest that genetically BMT might be an independent ethnic population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that the MICA alanine repeat is not a disease-associated factor in POHS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Among whites, carriage of the MGMT Phe84 odds ratio (OR), 0.71; 95% confidence interval (95% CI), 0.51-0.98 or Val143 (OR, 0.66; 95% CI, 0.47-0.92) allele was associated with a decreased risk of head and neck cancer; the haplotype distribution for MGMT differed significantly between cases and controls (covariate-adjusted global permutation test, P = 0.012).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Polymorphisms in the DNA repair enzyme gene XRCC3 241Met was associated with an increased risk of second neoplasms, and polymorphisms of the XRCC1 399Gln gene were associated with a decreased risk of all-cause mortality in patients with primary OSCC. These findings require confirmation in other populations before the clinical implications can be considered.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pooled data from two population-based studies (1,457 cases and 1,351 controls) were analyzed to examine associations between 28 single-nucleotide polymorphisms (SNPs) in nine DNA repair genes (APEX1, BRCA2, ERCC2, ERCC4, MGMT, MUTYH, OGG1, XPC, and XRCC1) and prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated interactions between dietary factors and the MGMT Ile143Val polymorphism in relation to breast, colorectal and prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, these two MGMT polymorphisms may jointly play a role, in the etiology of bladder cancer in southern Chinese population. Larger studies are warranted to validate our findings.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In our study, we examined the presence of alterations in MEN1 gene in a series of 39 patients who had undergone surgery for sporadic pHPT (35 with parathyroid adenoma or hyperplasia, 4 with a carcinoma).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Should routine analysis of the MEN1 gene be performed in all patients with primary hyperparathyroidism under 40 years of age?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutation screening of the MEN1 gene has been recommended for patients who meet clinical criteria for MEN1 (at least two of the following: parathyroid hyperplasia, pancreatic endocrine tumour or pituitary adenoma) and those in whom a diagnosis of MEN1 is suspected.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The finding of MEN1 germ-line mutation in all patients with familial MEN1 syndrome suggests that genetic screening should be useful in our population to identify affected individuals within a kindred and allow early detection of MEN1-related tumours.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study, based on a large group of MEN1 patients, shows that pituitary adenomas occur in 42% of the cases and are characterized by a larger size and a more aggressive presentation than without MEN1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[More than 50 disease-associated mutations of the Mediterranean fever gene (MEFV) have been identified in familial Mediterranean fever (FMF), some of which were shown to have different clinical, diagnostic, prognostic, and therapeutic implications.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Familial mediterranean fever (FMF) is a hereditary autoinflammatory autosomal recessive disease caused by mutations in the MEFV gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To assess the protective as well as the modulating affect of MEFV mutation carriage on various inflammatory disease states, we sought to define the frequency of MEFV mutations in Israeli Jewish individuals of various ethnicities, including those with low frequency of FMF, which were not in the focus of our attention hitherto.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated the hypothesis that low-penetrance mutations in genes (TNFRSF1A, MEFV and NALP3/CIAS1) associated with hereditary periodic fever syndromes (HPFs) might be risk factors for AA amyloidosis among patients with chronic inflammatory disorders, including rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), Crohn's disease, undiagnosed recurrent fevers and HPFs themselves.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Given that BD and FMF have similar pathophysiological, epidemiological, and clinical features, we hypothesized that the gene responsible for FMF, MEFV, may also play a role in the pathogenesis of BD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association of the HOPA(12bp) polymorphism with schizophrenia in the NIMH Genetics Initiative for Schizophrenia sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In Chinese RTT patients, the MECP2 mutations are mostly of paternal origin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Through the use of post-PCR high-performance liquid chromatography, 65 percent of 20 RS patients were found to have mutation(s) in the MECP2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel exon 1 mutations in MECP2 implicate isoform MeCP2_e1 in classical Rett syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The true frequency of MECP2 mutations in the mentally retarded has probably been overestimated. Based on our data, the frequency of MECP2 mutations in mentally retarded males is 0.2% (1/475).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High frequency of nonrecurrent MECP2 duplications among Brazilian males with mental retardation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results do not support previous evidence that genetic variation of the ME2 gene predisposes to common IGE syndromes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[cumulative cigarette smoking plays a pivotal role in the association between mEH polymorphisms and lung cancer risk, altering the direction of risk (in the case of the very low activity genotype) from a risk factor in nonsmokers to a relatively protective factor in heavy smokers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study aimed to characterize the TP53 mutational spectrum in patients suspected to have LFS in Portugal and to evaluate the influence of the MDM2-SNP309 and TP53-72Arg variants and of telomere length on age of tumor onset.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results indicate an association between the presence of G at position minus sign2518 in the MCP-1 promoter region and the presence of cutaneous vasculitis among patients with SLE. This polymorphism does not seem to influence the susceptibility to SLE nor the appearance of lupus nephritis. Further studies are necessary in order to elucidate the role of this polymorphism in the pathogenesis of other inflammatory autoimmune diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The objective of this study was to identify genetic variants of the MC3R gene and determine its association with childhood obesity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The risk of VVS is increased with proinflammatory genetic variants of IL1RN and MC1R, and combined genetic effects are associated with additive risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Protective effect of copy number polymorphism of glutathione S-transferase T1 gene on melanoma risk in presence of CDKN2A mutations, MC1R variants and host-related phenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Two MC1R germline variants, Arg151Cys and Asp294His, were significantly associated with melanoma in Sardinia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MC1R variant alleles and malignant melanoma risk in Israel.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated the effect of MC1R variants on melanoma using a large, international population-based study design with complete determination of all MC1R coding region variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These preliminary data suggest a role for these genes in MS pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Polymorphism of the MBP or another gene in its vicinity appears to contribute to the etiology of MS for the subgroups of DR4- and DR5-positive Italians and Russians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The results of the study suggest that genes may interact in ways that either synergize or modify the effect of a single genetic effect and imply that association studies must be interpreted within the genetic background of the populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that inflammation or an active immune response may induce an increased amount of HTLV-I-infected T cells, leading to a high provirus load.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Characterization of mannose-binding lectin gene polymorphism among human T-cell lymphotropic virus 1 and 2-infected asymptomatic subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data do not support associations between the mannose-binding lectin allelic variants studied and clinical expression of systemic lupus erythematosus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of combinations of gene variants revealed that the strong association with SLE for HLA DR3-DQ2-C4AQ0 remained after combination with FcgammaRIIa R/R, FcgammaRIIIa F/F, and MBL-low (OR>2).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Only in SLE patients fulfilling > or =4 ACR criteria an increased frequency of MBL variant alleles was found.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We determined the -159T mutation of the CD14 gene, the 896G mutation of the toll-like receptor 4 gene, the 3020insC mutation of the NOD2 gene (NOD2-3020insC), the IL-6 174G/C promoter polymorphism (IL6-174G/C), and the mannose-binding lectin genotype and their association to the subsequent development of neonatal sepsis in a large cohort of very low birth weight (VLBW) infants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[As MBL2 gene polymorphism is associated to an increased susceptibility to infection, we aimed to determine genetic variations in the MBL2 gene in rheumatic heart disease (RHD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of MBL gene polymorphisms with major bacterial infection in patients treated with high-dose chemotherapy and autologous PBSCT.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We evaluated whether women with vulvar vestibulitis syndrome (VVS) could be subdivided on the basis of genotyping the polymorphic mannose-binding lectin (MBL) gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To determine whether variant alleles in the coding portion of the mannose-binding lectin (MBL) gene are associated with increased susceptibility to systemic lupus erythematosus (SLE) and concomitant infections.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[After a preliminary report associating these variations with coronary artery disease (CAD), we determined MBL genotypes in 3 American Indian communities experiencing an increased mortality and morbidity from CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single nucleotide polymorphisms of the mannose-binding lectin are associated with susceptibility to primary biliary cirrhosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results demonstrate a role for the MBD2 gene in breast carcinogenesis in premenopausal women. These findings suggest that genetic variations in methylation related genes may potentially serve as a biomarker in risk estimates for breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[However, when stratified on the +766C>T polymorphism of exon 3 of the LRP gene, the IB1/JIP-1 polymorphism was strongly associated with AD in subjects bearing the CC genotype in the LRP gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Significant association was observed for monoamine oxidase-B(MAO-B) variant allele G and PD, whereas no difference in genotype and allele frequencies was observed for manganese-superoxide dismutase (MnSOD), dopamine receptor-D2(DRD2), and dopamine transporter (DAT) genes between controls and PD cases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate whether Parkinson's disease(PD) is associated with genetic polymorphism of intron 13 of monoamine oxidase B(MAO-B) and NAD(P)H: quinone oxidoreductase(NQO1) gene cDNA 609C to T.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The distribution of selected polymorphic variants in the serotonin receptor type 2A and 1Dbeta (5-HT(2A), 5-HT(1Dbeta)), dopamine transporter (DAT), dopamine receptor type 4 (DRD4) and monoamine-oxidase A (MAO-A) genes were analysed in 71 OCD cases and 129 control individuals in the genetically homogeneous Afrikaner population, by means of case-control association studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Additional evidence that genetic variation of MAO-A gene supports a gender subtype in obsessive-compulsive disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, our data suggest that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for major depressive disorder in females.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results provide fairly consistent evidence that high-activity variants of the MAOA promoter polymorphism confer a modestly higher risk for depression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationship between the Fnu4HI site polymorphism of monoamine oxidase A gene and Parkinson's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To ascertain whether mood disorders, including bipolar and unipolar, are genetically associated with the monoamine oxidase A (MAOA) or monoamine oxidase B (MAOB) gene in the Chinese population, 132 cases of mood disorder and 88 normal controls were genotyped for the MAOA(CA)n, MAOB(GT)n, and MAOB(TG)n loci by the method of amplification fragment length polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meta-analysis of the association between the monoamine oxidase-A gene and mood disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that functional genetic polymorphisms of the 5-HT system may influence the vulnerability to panic attacks and add to the growing evidence of inhibitory function of 5-HT in the neuronal circuitry of panic.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[from others Brazilian studies with AD patients are also reported at this short review.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results do not confirm the hypothesis that there is a simple correlation between single gene polymorphisms and a personality trait measured by the TCI and NEO-FFI scales.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association study between schizophrenia and monoamine oxidase A and B DNA polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results indicate that MAO-A may play a role in the development of alcoholism but the gene effect is very small.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that this monoamine oxidase A polymorphism could play a role in susceptibility to alcoholism, which may differ across sexes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results support the hypothesis that binge drinking behavior in young adulthood may be influenced by neurobiological differences in serotonergic function conferred by functional polymorphisms in genes involved in serotonin processing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The long-repeat allelic variants (>4-repeats) and 2-repeat allele of the DRD4 exon 3 VNTR polymorphism might be risk alleles for individual vulnerability to heroin addiction in Chinese men, but the MAOA promoter VNTR polymorphism does not mean that the partial dominant inherited mode might involved in the genetics of heroin dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of autism severity with a monoamine oxidase A functional polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[All three complementary approaches employed (family-based, case-control and quantitative trait design) suggest a role for the MAO A promoter-region polymorphism in conferring risk for ADHD in our patient population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the short 3.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention-deficit/hyperactivity disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and meta-analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Where possible, asthma severity scores were assigned, ALOX5AP G-336A, ALOX5 G-1708A, LTC4S A-444C and G-1072A, GPX4 C718T, and CYSTLTR1 T927C genotypes were determined and uLTE(4) was measured in acute and convalescent samples.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The relevance of leukotriene C(4) synthase gene A (-444) C polymorphism to clinical responsiveness to montelukast in patients with asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The sorted genes allow us to draw novel hypotheses for future studies of HCV infection to ultimately identify bona fide genes and their variations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We genotyped 26 SNPs that had previously been interrogated for association with montelukast response in five candidate genes (ABCC1, ALOX5, CYSLTR1, LTA4H, LTC4S) in a population of 577 asthmatics who participated in a clinical trial comparing intermittent and continuous-release zileuton to placebo.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The data suggest that genetic determinants of response to infliximab therapy exist in the HLA complex.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Haplotype-specific pattern of association of human major histocompatibility complex with non-Hodgkin's lymphoma outcome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Systemic lupus erythematosus with nephritis is strongly associated with the TNFB*2 homozygote in the Korean population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We adapted template-directed dye-terminator incorporation with fluorescence polarization detection (TDI-FP) to the analysis of eight SNPs implicated in mediating the sepsis syndrome: TNF-alpha (-308), TNF-alpha (-238), TNF-beta (+250), IL-1beta (+3953), IL-6 (-174), IL-10 (-592), plasminogen activator inhibitor-1 (PAI-1 (-675)), and TLR4 299 (+1032).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Microsatellite TNFa is significantly associated with both the susceptibility to and outcome of severe sepsis. In contrast, microsatellite TNFb is neither associated with the susceptibility to severe sepsis nor with the outcome of severe sepsis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In severe sepsis, tumor necrosis factor-beta (TNF-beta) NcoI polymorphism was associated with increased mortality.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest donor TNFalpha-857 CC genotype is related to a higher incidence of grade II-IV aGVHD, and patients with TNFbeta + 252 AA genotype have protection against the risk of grade II-IV aGVHD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In an effort to discover polymorphism(s) in genes whose variant(s) have been implicated in asthma phenotypes, we examined the genetic effects of TNF (TNFA and TNFB) polymorphisms on asthma and total serum IgE level.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene-gene synergistic effect on atopic asthma: tumour necrosis factor-alpha-308 and lymphotoxin-alpha-NcoI in Taiwan's children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate the association of differences in asthma-related phenotypes with two biallelic polymorphisms: a G to A substitution at position - 308 of the TNFalpha gene promoter (TNF1 and TNF2 alleles) and an NcoI polymorphism in the first intron of the lymphotoxin alpha gene (LT-alpha*1 and LT-alpha*2 alleles).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of a lymphotoxin-alpha gene polymorphism and atopic asthma in Taiwanese children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Duration of non-Insulin-dependent diabetes mellitus and the TNF-beta NcoI genotype as predictive factors in proliferative diabetic retinopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Study on some susceptible genes of systemic lupus erythematosus in Han nationality of China.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German origin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Since these variants are implicated in the susceptibility and severity of several immunologic disorders, the results support the hypothesis that common genetic determinants influence shared mechanisms of autoimmunity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There was no association between the TNFB polymorphism and ARDS mortality.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest an effect of the TNFalpha-308 polymorphism on the age at onset of late AD. This represents additional evidence of the importance of genetic variation at the proinflammatory components in the origin and progression of this common NEUROLOGICALenerative disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated the association of polymorphisms in the tumor necrosis factor (TNF) microsatellite as well as the promoter region of the TNFA gene and the TNFB gene with palmoplantar pustulosis (PPP).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate the association between tumor necrosis factor-beta (TNF-beta) gene polymorphisms and coronary heart disease (CHD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A positive family history of psoriasis was associated with a higher B1 allele frequency in NcoI TNFbeta (P = 0.011).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We examined the association of seven single nucleotide polymorphisms (SNPs) across the LTA gene, and their related haplotypes, with risk of myocardial infarction (MI) in the International Study of Infarct Survival (ISIS) case-control study involving 6,928 non-fatal MI cases and 2,712 unrelated controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have identified functional SNPs within the lymphotoxin-alpha gene located on chromosome 6p21 conferred susceptibility to MI.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest that combined genotypes composed of the TNF-alpha and LT-alpha gene polymorphisms may influence the susceptibility to chronic periodontitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Support Vector Machine based feature selection method in this research found novel association between combinations of SNPs and T2D in a Korean population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Several reports have indicated that different HLA products and genes may be risk factors for or protective factors against the development of atopy. We report no association between polymorphisms in the LT-alpha and TAP-1 genes alone and atopic diseases in the central Europe Caucasian (Czech) population, but there was an interesting interaction between the TAP333 and LT-alpha polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study confirms that HLA class III region seems involved in familial predisposition to atopy, and C4B gene probably acts as a marker of a more restricted subregion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We previously reported that the G2019S LRRK2 mutation-which is the most common LRRK2 mutation-was not found in a sample of 453 Korean PD patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Absence of commonly reported leucine-rich repeat kinase 2 mutations in Eastern Indian Parkinson's disease patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[According to our data, the variation at the LRPAP1 gene is associated with the risk of developing LOAD. This is in agreement with the role of the LRPAP1 protein in the amyloidogenic pathway.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These data suggest that LRP6, VEGF, and VLDLR may play a role in the risk of developing AMD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our objective was to investigate the role of the APOE coding region polymorphisms epsilon 2, epsilon 3, and epsilon 4 and APOE promoter variants A/T at position -491 and G/T at -219, as well as LRP polymorphism C/T, as risk factors for AD in Brazilian individuals.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic interaction between tau and the apolipoprotein E receptor LRP1 Increases Alzheimer's disease risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We genotyped 210 patients with early MI (<55 years) and 200 healthy control participants for three polymorphisms in the LRP, LRPAP and alpha2 M genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We present an investigation of joint genetic and clinical factors associated with atherosclerosis that shows predictive results for both cases, as well as enhanced performance for their combination.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The T allele of the C766T polymorphism in the LRP1 gene is associated with an increased risk of breast cancer development in women of Caucasian origin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The S447X polymorphism of the lipoprotein lipase gene is associated with lipoprotein lipid and blood pressure levels in Chinese patients with essential hypertension.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A cohort of 1002 heterozygous FH patients was genotyped for polymorphisms in the genes encoding for ATP-binding cassette transporter A1, apolipoprotein (apo) AIV, apoCIII, apoE, cholesteryl transfer ester protein, hepatic lipase, lipoprotein lipase, and two paraoxonases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results indicated a strong association of sequence variants of HMGCR, SREBF1 and ABCG8 genes with the reduction of LDL-C after statin treatment in a Chinese population. Future studies on the genes of drug-metabolism enzymes and transporters are warranted.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[PPARgamma and LPL have intractable roles in pathways that lead to CAD, but their gene polymorphisms associate differently.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The presence of the S447X lipoprotein lipase polymorphism was not associated with the incidence of CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hence, we examined the influence of the -93T/G, D9N, N291S, and S447X polymorphisms in the lipoprotein lipase (LPL) gene on CAD risk and lipid levels in Croatian patients with and without angiographically confirmed CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We identified a cluster of polymorphisms in APOE, SOAT1, APOE 5'-untranslated region, OLR1, CYP46A1, LPL, LIPA, and APOA4 conferring significant (p = .0002) susceptibility for Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lipoprotein lipase 1595 c/g and hepatic lipase -480 c/t polymorphisms--impact on lipid profile in incident dialysis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[For a modest panel of selected genotypes, CHD-risk estimates incorporating CRFs and genotype-risk factor interactions were more effective than risk estimates that used CRFs alone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Results from the current study suggest that interaction effects between alcohol consumption and HDL cholesterol metabolism gene variation influence the risk of incident CHD in black men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effect of gender on phenotypic expression of the S447X mutation in LPL: the Copenhagen City Heart Study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variants in lipoprotein lipase may affect triglycerides, high-density lipoprotein (HDL), and risk of ischemic heart disease (IHD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gender-related association between the -93T-->G/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[An intronic single nucleotide polymorphism in ABCA1 and the APOE epsilon3 allele are associated with reduced LDLc lowering by statins and identify individuals who may be resistant to maximal LDLc lowering by statins.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of lipoprotein lipase (LPL) single nucleotide polymorphisms with type 2 diabetes mellitus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Adding SNPs previously associated with fasting glucose, insulin, lipids or obesity to a genetic risk score for type 2 diabetes significantly increases the power to discriminate between people with and without clinically manifest type 2 diabetes compared with a model including only conventional type 2 diabetes loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The independent risk conferred by genetic variants encoding pathways such as inflammation and lipid metabolism, not adequately reflected by conventional biomarkers, may identify high-risk individuals for intensified control of modifiable risk factors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[on the genetic causes of lipase activities outside of the normal range should be drawn with caution.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that carriers of N291S or combined D9N/ - 93T --> G mutations in the LPL gene are at substantially increased risk of pre-eclampsia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lipoprotein lipase gene mutations and the risk of cardiovascular diseases in children with obesity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To investigate the impact of lipoprotein lipase (LPL) gene S447X polymorphism on the relation between central obesity and lipid levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of the present study was to examine the impact of the defective D9N and the null P207L mutations in the lipoprotein lipase (LPL) gene on high density lipoprotein (HDL) particle size in relation to specific environmental factors such as obesity, gender and menopausal status.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Allele and genotype frequency distributions differed between Cases and Controls. Lp(a) concentrations differed according to PNR genotypes]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Recently, a unique homozygous mutation in LMNA, which encodes lamin A/C, a component of the nuclear envelope, was identified in members of three Algerian families with ARCMT2 linked to chromosome 1q21.2-q21.3.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings indicate that approximately half of the variance in mean s.c. abd. AS can be attributed to familial factors and that genetic variation in LMNA might not only underlie rare cases of FPLD, but may also contribute to variation in adipocyte size in the general population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ MBL deficiency is not a risk factor for SLE in women from the Canary Islands, but it is associated with lower prevalence of autoantibodies and with later age at disease onset and at SLE diagnosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study confirms a role for HSL in glucose homeostasis and the reduced frequency of the low expressing -60G promoter variant in obese individuals, together with existing published data, suggests that this allele might be protective against obesity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ HSLi6 A5 homozygosity is a risk factor for body fat accumulation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pharmacogenetic study of apolipoprotein E, cholesteryl ester transfer protein and hepatic lipase genes and simvastatin therapy in Brazilian subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The -514C/T polymorphism of the hepatic lipase gene significantly modulates the HDL-cholesterol response to statin treatment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The Intermountain Healthcares Coronary Genetics study demonstrates the ability of a multigenic, multipathway GRS to improve discrimination of angiographic CAD. Genetic risk scores promise to increase understanding of the genetic basis of CAD and improve identification of individuals at increased CAD risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Family-based association studies of lipid gene polymorphisms in coronary artery disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Analysis of our data revealed an independent association between the HL gene promoter polymorphisms and HDL-C levels in Taiwanese-Chinese. The data also suggests that the HL-514C/T and HL-250G/A polymorphisms interact with sex and obesity on HDL-C levels. The findings give clues for identifying high risk population in preventive medicine and clinical diagnosis. The subsequent impacts on treatment profiles and prognosis were derived from this study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Although the use of obese-only samples is theoretically a useful approach to detect interactions, few genotype-by-nutrient interactions have been suggested in obese European women after the analysis of candidate polymorphisms and the selected nutrient variables. The most remarkable multiplicative interaction found in this study refers to the combination of the hepatic lipase gene polymorphism -514 C > T and fibre intake.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The LIPC-480 TT genotype predicted an increase in CHD in both ethnic groups, and physical activity altered this relation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between -514C-->T polymorphism of the hepatic lipase gene and coronary artery disease in a Turkish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No significant interactions were seen between any of these polymorphisms and duration or dose of cigarette smoking. The gene-environment interaction data suggest that the subtle effects of some of these variants on breast cancer risk may be magnified in the presence of certain exposures.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pooling data within a large consortium has helped to clarify associations of SNPs with breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ILT6 deficiency is associated with MS in the German population and hence a likely risk factor for autoimmune disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study points to a gene-dose-dependent, protective role for LILRA3, the deletion of which synergizes with HLA-DRB1(*)1501 to increase the risk of R-MS. We also investigated whether the risk of suffering R-MS might be influenced by the genotypic diversity of killer-cell Ig-like receptors (KIRs), located only approximately 400 kb telomeric to LILRA3, and implicated in autoimmunity and defence against viruses.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our findings suggest that genetic polymorphisms of RAD52, ERCC1, and hMLH1 may be associated with breast cancer risk in Korean women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genotypic association was found for the c.1914GC --> AT polymorphism in 42 CAE patients compared with 110 population controls (chi2 = 6.66, df = 1, P = 0.01), providing evidence for a so far undetected susceptibility allele for CAE in the LGI4 region.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[our results show that a common variant in LEP may be associated with the risk of developing breast cancer supporting the hypothesis that leptin is involved in breast carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In Caucasians, LEP SNPs also tended to be associated with weight (p = 0.0471), and PYY rs11684664 was associated with obesity-related phenotypes in women only (p = 0.010-0.026).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study provides basic information concerning the prevalence of leptin gene polymorphisms in Thai children with early onset obesity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Larger studies would be needed to confirm and further clarify the relations between functional variants in the leptin gene and preeclampsia risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ According to our results we hypothesize that the polymorphism in LEP gene may be relevant to PC risk and progression, supporting the hypothesis for leptin involvement in cancer ethiopathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our prospective study suggests that genetic variation in IL10 and possibly TLR4 is associated with prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These results suggest that no mutations in either the promoter region at the about 100 bp 5'-flanking region of the gene, or in any of the three exons, are involved in the development of NIDDM or IGT associated with obesity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, we observed that several polymorphisms in LEPR that had previous reports of association with BMI were significantly replicated in our samples and newly found that some variations of LEP were associated with T2DM and metabolic traits.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Adjustment for LDL-C levels by logistic regression or Mendelian Randomisation models abolished the significant association between rs2228671 with CAD completely, indicating a functional link between the genetic variant at the LDLR gene locus, change in LDL-C and risk of CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our data indicate that ChM-II Val58Ile polymorphism is associated with radiographic progression of joint destruction, particularly in German patients with RA negative for SE.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel mutations identification in exon 4 of LDLR gene in patients with moderate hypercholesterolemia in a Venezuelan population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A total of 118 FH subjects could be classified into three groups according to the type of LDLR mutations (null mutations, missense mutations affecting the ligand binding 3-5 repeat, and missense mutations outside this domain).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To evaluate the relationship between low density lipoprotein receptor (LDLR) genetic variant and AD, independently or in concert with the APOE epsilon4 allele, we examined three LDLR polymorphisms located in exons 8 (rs 11669576), 10 (rs 5930), and 13 (rs 5925), in a large group of 322 Spanish AD patients and 314 controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[odds ratios.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional interaction between APOE4 and LDL receptor isoforms in Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated the LDLR gene mutations in 205 unrelated Japanese FH (familial hypercholesterolemia) heterozygotes to see if there is a prevalence of common mutations in the Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Two new large deletions in the low density lipoprotein receptor (LDLR) gene not revealed by PCR-based molecular diagnosis of familial hypercholesterolemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present study therefore adds to our previous evidence implicating LDLR as a locus for obesity in patients with essential hypertension.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Marked association of a RFLP for the low density lipoprotein receptor gene with obesity in essential hypertensives.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the Italian population the LCT-13910C>T polymorphism is not associated to the risk for colorectal cancer or polyps.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The authors validate a denaturing high-performance liquid chromatography (dHPLC)-based assay versus conventional genotype sequencing in detecting the C/T(-13910) polymorphism of LCT and evaluate its prevalence in 2 different Italian geographical areas and in colorectal cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have demonstrated that the lysosome associated membrane protein (LAMP-1) is elevated in plasma from approximately 70% of lysosomal storage disorder patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study suggests that the allele *2 of LAPTM4B might be the risk factor of lung cancer, which could be associated with genetic susceptibility of lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that the polymorphism in intron 25 plays a role in the genetic predisposition of male schizophrenia in the Japanese sample]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[While we were able to replicate a few of the previous GWAS SNPs, we were not able to confirm the vast majority of these associations in our AA population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[From 1990 through 2000, urologic measures of BPH were assessed biennially from lower urinary tract symptom severity, peak flow rates, prostate volume, serum prostate specific antigen (PSA) level, acute urinary retention, and treatment for BPH.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[When combined, the adjusted odds ratio for having prostate cancer was 13.92 (95% CI, 6.6 to 29.2; P =.0001) for patients with high hK2 levels and at least one T allele.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest a role for the KLK2 gene in prostate cancer susceptibility and imply that this role may be realized at least in part by the induction of increases in hK2 production.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[B2 receptor promoter polymorphism may represent a susceptibility marker for essential hypertension in African-Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, we examined 50 non-cancerous tissues from Japanese patients with primary gastric cancer to determine the presence of genetic polymorphisms in the KLK12 gene using polymerase chain reaction (PCR)-single-strand conformation polymorphism and sequencing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, there are polymorphisms in the regulatory region of human tissue kallikrein gene in the Chinese Han people. Differences in both allele frequencies and genotype frequencies between these two groups have provided evidence towards the association of hypertension with the polymorphisms in this studied site.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results indicate that the gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It is unlikely that variants in different members of the KLF gene family play a major role in T2D in the French population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We observed the frequencies of single nucleotide polymorphisms, that is, G-395A in the promoter region, C1818T in exon 4, and a functional variant, KL-VS, of KLOTHO gene in Koreans, and we investigated their relationships with the presence of coronary artery disease (CAD) in patients who had undergone coronary angiograms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, Southeast Asian AML patients with a favorable karyotype including t(8;21)/AML-ETO, inv(16)(CBF beta/SMMHC), and t(15;17)/PML-RAR alpha were genotyped for KIT and FLT3 RTK mutations by PCR and sequencing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It was concluded that certain KIR genes and genotypes may associate with cervical neoplasia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This result strongly speaks for a role of KIR2DS1 on recognition of HLA-Cw6 in susceptibility to psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The developed application can estimate haplotype frequencies for every type of polymorphism and can effectively be used in genetic research as illustrated by a novel finding regarding the genetic susceptibility to psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The data obtained in this study imply that there may not be a direct association between KIR gene content in the genome and the presence of malignant melanoma, or melanoma progression. However, some HLA haplotypes could be predisposing to MM in the Bulgarian population. Furthermore, distinct KIR/HLA ligand combinations may be relevant to the development of malignancy whereby inhibition overrides activation of NK cells and T cells expressing NK-associated receptors, which in turn might facilitate tumor escape and progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results provide strong evidence for pathogenic variant(s) in the 276-kb region harboring IDE that influence intermediate AD phenotypes and risk for AD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A common variant associated with dyslexia reduces expression of the KIAA0319 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We analyzed the genetic polymorphisms of vascular endothelial growth factor (VEGF) and its receptors Fms-related tyrosine kinase-1, kinase insert domain receptor (KDR) in Japanese patients with Kawasaki disease (KD) and normal control subjects to examine whether these genes would contribute to the KD occurrence and/or the development of coronary artery lesion (CAL) in KD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have tested the association between JME phenotype and an intragenic marker in KCNQ3 by using the transmission disequilibrium test in 119 probands and their parents.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The significance of the G(-930)A polymorphism of CYBA was confirmed in the present study with adequate statistical power, which strengthens the hypothesis that this polymorphism is important in the pathogenesis of hypertension and confers susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The overall results supported that the genetic variants in the contractile pathway of VSMC could contribute to hypertension risk independently or in an interactive manner.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No significant association of PPARG, PGC1, IRS1, KCNJ11 and TCF7L2 gene polymorphisms and the age at diagnosis of T2DM was observed in the present study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated the effects of the E23K variant of KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11) on risk for SH in patients with type 2 diabetes (T2D).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have investigated three such genes, KCNJ3, KCNJ6 and KCNQ2, by association studies using a broad sample of idiopathic generalised epilepsy (IGE) unselected by syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These differences can help to identify LQTS patients and distinguish LQT1 from LQT2 genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The SALSA multiplex ligation-dependent probe amplification LQTS kit from MRC-Holland was used to analyze the 3 major LQTS-associated genes, KCNQ1, KCNH2, and SCN5A, and the 2 minor genes, KCNE1 and KCNE2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Retrospective analysis of the first 2,500 cases (1,515 female patients, average age at testing 23 +/- 17 years, range 0 to 90 years) scanned for mutations in 5 of the LQTS-susceptibility genes: KCNQ1 (LQT1), KCNH2 (LQT2), SCN5A (LQT3), KCNE1 (LQT5), and KCNE2 (LQT6).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results of this study suggest that a missense mutation in KCNE5 may be associated with nonfamilial or acquired forms of AF.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that in patients without RUNX1 mutation, several other molecular aberrations, separately or in combination, contribute to a common minimally differentiated phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The associations of Janus kinase-2 (JAK2) A830G polymorphism and the treatment outcomes in patients with acute myeloid leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data indicate that loss of wild-type clones at the progenitor level is a feature of MF (primary MF, post-ET MF, and post-PV MF), presumably due to expansion of the JAK2 V617F clone and that this characteristic is surprisingly independent of JAK2 V617F homozygosity, suggesting that additional genomic lesions may contribute to this unique molecular process that distinguishes MF from ET and PV.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A diagnosis of polycythemia vera was confirmed in 53% of 62 participants using WHO criteria, which includes JAK2 617V>F testing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High percentage of JAK2 exon 12 mutation in Asian patients with polycythemia vera.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[JAK2 exon 12 mutation in JAK2V617F-negative polycythemia vera.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The significant associations between certain gene variants with concentration variations in serum C-reactive protein and homocysteine among adult women need to be confirmed in further genetic association studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results suggest, that the Pl(A1/A1) genotype of Pl(A) GPIIIa polymorphism is associated with more severe CAD in male Caucasian patients from the north region of Poland.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The findings of this study suggest that Pl(A1/A1) homozygotes may be prone to early atherosclerosis and more rapid progression of stable CAD whereas carriers of the Pl(A2) allele are more prone to thrombotic complications.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[AR appears to be unrelated to differences in platelet COX-1 and COX-2 expression or to a novel platelet COX-1 SNP and the PlA(1)/A(2) SNP. However, a correlation exists to elevated eicosanoids generated by oxidative stress indicating COX-1-independent pathways for the generation of platelet activating molecules represent a potential cause for AR.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ In patients with FHC polymorphisms in factor VII and GPIIIa genes but not C677T polymorphism of MTHFR gene were associated with the presence of IHD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have studied structure of polymorphisms of genes of blood clotting factors II, V, VII, platelet membrane glycoprotein IIIa (GPIIIa) and enzyme methylenetetrahydrofolate reductase (MTHFR) in patients with ischemic heart disease (IHD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest that the Pl(A2) polymorphism is a genetic determinant of ischemic stroke in a selected high-risk hypertensive population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data suggest that inheritance of the integrin beta(3) Leu33Pro polymorphism may increase the breast cancer risk by age 45 in the German population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Do BRCA1 modifiers also affect the risk of breast cancer in non-carriers?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ A novel Phe171Cys mutation in the alpha(IIb) gene of patients with GT is associated with abrogation of alpha(IIb)beta(3) complex formation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Individuals homozygous for the Leu33Pro polymorphism of the beta3 integrin subunit have an increased cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Molecular genetics of microvascular disease in diabetic retinopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that genetic variants in the CD11 cluster may play a role in the development of gastric ulcer in chronic H. pylori infection presumably by influencing leukocyte adhesion. The biological effect of genetic variants of CD11c in gastric inflammation needs further clarification.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of platelet adhesive molecules: association with breast cancer risk and clinical presentation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Prevalence of genetic risk factors for coronary artery disease in Corsica island (France).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ This study does not support the association between the PIA1/A2 polymorphism and cryptogenic stroke or TIA in patients aged 45 or less.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The platelet glycoproteins polymorphisms studied are not an independent risk factor for AMI.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphism C807T increases the risk for premature MI.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results suggest that these polymorphisms play a minor role in PIH.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The BglII gene polymorphism of the alpha2beta1 integrin, which is a platelet collagen receptor, has been suggested as a genetic risk factor for diabetic retinopathy in Japanese subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These data suggest that Pl(A2) carriers, especially those who are ACE DD, are statistically less prevalent among older healthy blood donors compared with their younger counterparts. These observations suggest an important, deleterious, time-dependent impact of the Pl(A2) allele, as well as the ACE DD/Pl(A2) allelic combination, on overall health and longevity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data indicate hat patients with BD are affected by the glycoprotein Ia gene 807TT genotypes and carrying 807T allele. The risk of thrombosis is significantly higher in patients who have 807TT and 807CT genotypes than in patients who have 807CC genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of our study was to investigate whether common polymorphisms in the genes regulating the early insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor IGF-1R; GAG1013GAA, plasma cell membrane glycoprotein 1 PC-1; K121Q, insulin receptor substrate IRS-1; G972R, insulin receptor substrate 2 IRS-2; G1057D and phosphatidylinositol 3-kinase p85 alpha PI3K; M326I) affect the weight change and development of Type 2 diabetes in the Finnish Diabetes Prevention Study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data provide evidence for a strong association between type 2 diabetes and the G1057D common genetic variant of IRS-2, which appears to be protective against type 2 diabetes in a codominant fashion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[New amino acid substitutions in the IRS-2 gene in Finnish and Chinese subjects with late-onset type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of this study was to investigate the association of Gly1057Asp polymorphism in insulin receptor substrate-2 (IRS-2) gene among patients with type 2 diabetes in well defined ethnic groups from Djerba Island in Southeastern Tunisia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[we found limited evidence for a role of gene variants of the insulin signaling pathway and prevalence of advanced colorectal adenoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate for a contributory role in type 2 diabetes susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Considering their key role in both insulin action and insulin secretion, IRS-1 and IRS-2 molecules have been considered plausible candidate genes involved in the pathogenesis of Type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that the Arg(972) IRS-1 variant could contribute to the risk for atherosclerotic cardiovascular diseases associated with type 2 diabetes by producing a cluster of insulin resistance-related metabolic abnormalities.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In order to investigate whether the variances in the candidate genes (Insulin receptor substrate IRS-1, beta3-adrenergic receptor ADRB3, 3 beta-hydro-xysteroid dehydrogenase HSD3B2, glucocorticoid receptor GRL and 21-hydroxylase CYP21) which affect the metabolism of adrenal steroids hormone and body composition, are associated with precocious puberty in Chinese girls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lack of association of the Gly972Arg mutation of the insulin receptor substrate-1 gene with coronary artery disease in the Austrian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[our results help to understand the role of the IRF5 locus in SLE susceptibility by clearly separating protection from susceptibility as caused by independent polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[An association between JIA and a previously unreported 3'UTR polymorphism of IRF-1 was observed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic epidemiology of juvenile idiopathic arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[DNA from 765 patients with JIA and 508 unaffected control subjects was genotyped for 4 single-nucleotide polymorphisms in the IRF-1 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association study between the IL4, IL13, IRF1 and UGRP1 genes in chromosomal 5q31 region and Chinese Graves' disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[DNA polymorphisms of the insulin receptor gene and non-insulin-dependent diabetes mellitus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, our results suggested that a susceptibility gene for PCOS was located on chromosome 19p13.3 in the insulin receptor gene region. It remains to be determined if this susceptibility gene is the insulin receptor gene itself or a closely located gene. Since insulin stimulates androgen secretion by the ovarian stroma it is likely that INSR function in the ovary is involved in the genetic susceptibility ot PCOS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[DNA samples from forty-four adolescent girls with PCOS and 50 healthy controls were analyzed by PCR-RFLP and direct DNA sequencing to determine the genotypic frequency of 17 different polymorphic loci on the FSHR (A307T, N680S), CYP17 (-34 T/C), CYP1A1 (T6235C), CAPN10 (44, 43, 19, 63), INSR (exon 17 C/T), SERPINE1 (4G/5G) genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Insulin receptor gene polymorphism in myocardial infarction patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present study thus suggests that there could be a relationship of plasma angiotensinogen with INSR genotype, and of each with hypertension.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[An in-frame insertion in exon 3 and a nonsense mutation in exon 2 of the insulin receptor gene associated with severe insulin resistance in a patient with Rabson-Mendenhall syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We investigated the contribution of Type 1 diabetes susceptibility genes to the progression of the insulin-deficient state and mode of onset of Type 2 diabetes in GAD Ab-positive (GAD-Ab+) patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Possible correlation between non-insulin dependent diabetes mellitus (NIDDM) and restriction fragment length polymorphism (RFLP) of the 5'-flanking region of insulin gene in Korean diabetic population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the Sikhs no association with non-insulin-dependent diabetes mellitus was seen with the hypervariable region of the insulin gene or with HLA-DR/DQ/DX alpha chain restriction fragment length polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The use of DNA analysis for diagnostics of hereditary premature ovarian failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These data strengthen the concept of the INHalpha gene as a candidate for ovarian failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Variants in the inhibin alpha gene are strongly associated with premature ovarian failure in Indian patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The prevalence of INHalpha gene variants is not increased in PE. Due to its frequency, the 769G-->A transition may be considered a polymorphism present in the general Italian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There were no statistically significant allele or haplotype frequency differences between cases and controls. Therefore, these results provide no evidence that these loci are associated with CD in this sample population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Promoter polymorphism in the candidate genes, IL-4, IL-9, TGF-beta1, for atopy and asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Due to its rapid and relatively inexpensive performance and accuracy, the presented allelic discrimination assay for CXCR2 polymorphisms has wide applicability, especially for high-throughput sample analysis in large population genotyping studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that - with the possible exception of IL-1beta- genetic variation associated with differential expression of the selected pro- and anti-inflammatory cytokines is unlikely to play a major role in susceptibility to and prognosis in CMM.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study showed that the IL8-251*A allele could be related to the development of distal gastric cancer in this Mexican population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A systematic review of meta-analyses on gene polymorphisms and gastric cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of inflammation gene polymorphisms on pain severity in lung cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggested that the IL-8 -251 T>A polymorphism may be a relevant host susceptibility factor for bladder carcinoma development and may influence outcome after BCG immunotherapy. Similarly, NF-kappaB ATTG polymorphism may also modify risk-free survival of BCG-treated patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lack of association between pro-inflammatory cytokine (IL-6, IL-8 and TNF-alpha) gene polymorphisms and Graves' disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This observation draws attention to the possible importance of IL-8 polymorphism as a genetic predisposing factor in the pathomechanism of H. pylori-induced duodenal ulcer disease, and to the relative protection from duodenal ulcer disease that is associated with the TT genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association between common SNPs in immunologic response-related genes and CRC is reported in the present study. Apart from shedding light on the mechanisms of malignancy initiation and progression, SNPs may improve appropriate screening for sub-populations at risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genetic association between CCR3 polymorphisms and the number of circulating eosinophils was revealed as a novel finding.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We found that the rs2522411SNP and the haplotype T-A in the IL-5 gene and the serum IL-5 levels were strongly associated with the allergic type of AD, but not with the nonallergic type of AD. The association of the rs6771148SNP and the haplotype T-C-T in the IL5RA gene with the blood eosinophil counts and the serum ECP levels indicates that the IL5RA gene ha]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The cytokine gene polymorphisms studied here do not appear to influence IBD susceptibility. There does, however, appear to be an influence on disease phenotype, particularly on CD site.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The mutant R576 allele of IL-4R may be one of the candidate genes for susceptibility to asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the interleukin-4 receptor alpha chain: association with traits of allergy and asthma in an admixed population in Hawaii.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Associations with IL6 -174 variants suggest that the C/C genotype has a protective effect (OR=0.13) while carriers of the G allele are more susceptible (OR=7.66) to EPF.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[RGMA and IL21R and their pathways are crucial in MS pathogenesis and warrant further studies as potential biomarkers and therapeutic targets.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results indicate that these variants are not significant genetic determinants of IBD, and that the IL4R gene is unlikely to be IBD1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alpha-1-antitrypsin (PI) and vitamin-D binding globulin (GC) phenotypes in rheumatoid arthritis: absence of an association.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[During analysis of role of allelic polymorphism of IL-4 genes in predisposition to hepatitis C development it is necessary to consider not only presence of allelic variants of promoter regions of the IL-4 genes, but also the polymorphism of genes coding molecules binding with this cytokine on target cells membranes and in its soluble form.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Impact of the IL-4 -590 C/T transition on the levels of Plasmodium falciparum specific IgE, IgG, IgG subclasses and total IgE in two sympatric ethnic groups living in Mali.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism in the promoter of the IL-4 gene is associated with asthma and is a disease modifier in terms of the severity of AHR.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Variants related to decreased anti-inflammatory cytokine production may lower risk of SGA. Furthermore, the same mechanism that protects against SGA might increase risk of spontaneous preterm birth.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[When UC patients were divided into ANCA positive and negative groups, it was found that there was significant difference in the gene frequencies of allele RP1, RP2 of IL-4 between two groups (63.7% vs 83.3%, 36.3% vs 16.7%, P < 0.05).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These data suggest that IL-4, IL-13 and IFN-gamma play an important roles in penicillins allergy. The IL-4RalphaQ576R polymorphism may involve in the development of penicillins allergy, and through modulating specific serum IgE levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These findings not only suggested that variants in the IL4, IL13, and IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The association between GD and the following polymorphisms in anti-inflammatory cytokines was studied in 107 patients with GD and 140 healthy controls: IL-4 (-1098T/G, -590T/C, -33C/T), IL-10 (-1082A/G, -819C/T, -592C/A) and TGF-beta (+869T/C, +915G/C).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The results suggest that IL-4 VNTR B1B1 genotype might be a predictor for the frequent relapse in childhood SSNS in Chinese.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We could not confirm the previously reported association between carriage of I3(709)*allele-2 and older age of onset. However, we found a trend for association between the homozygous state for this allele and older age of onset.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Since interleukin (IL)-4 gene polymorphisms have been associated with immune-mediated diseases, we have analysed the relationship between a variable number of tandem repeat polymorphism of the IL-4 gene and clinical and physiological features of 256 sporadic MS patients and 146 healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of interleukin-4 receptor and interleukin-4 promoter gene polymorphisms with systemic lupus erythematosus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association with alleles resulting in high IL-4 transcription and enhanced signalling activity suggests that IL-4 may have a role in the pathogenesis of Crohn's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our study showed association with JIA for the IL-4 -1098 T/G polymorphism. It also underlines the genetic contribution of IL-1 polymorphisms to the pathogenesis of JIA, as another polymorphism within the IL-1beta may influence the risk of the disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We examined the association between malignant lymphoma risk and the polymorphisms of the IL-1 gene family IL-1B -31 C/T, IL-1A -889 C/T, and IL-1RN 86-bp variable number of terminal repeat (VNTR) and myeloperoxidase (MPO -463 G/A).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, no association of the IL1B C(minus sign?31)T with HT was found, whereas combined frequency of the minor alleles of the IL1RN polymorphism was increased in the HT cohort studied]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The single nucleotide polymorphism of IL-1B-31C may contribute to the development of the gastric adenocarcinoma in the H. pylori-positive population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Allele 2 of the interleukin-1 receptor antagonist gene is associated with early gastric cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[According to their random-Odds Ratios, individuals carrying one of the IL-1RN *2, IL-1beta -511T variant alleles or homozygotes for MTHFR 677T are significantly at higher risk of gastric cancer than those with the wild type homozygote genotypes, showing high PARs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Genetic variations in cytokine and DNA repair genes contribute to susceptibility to HBV-related HCC. Smoking increased such genetic susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The genotype I/II for IL1-Ra and the frequency of allele II for IL1-Ra are associated with a higher susceptibility to KD, and thus may be useful markers for predicting the development of KD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A potential pharmacogenomic strategy for anticoagulant treatment in non-ST elevation acute coronary syndromes: the role of interleukin-1 receptor antagonist genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The purpose of this study was to determine the relationship between IL-1 gene family polymorphisms (IL-1RN, IL-1B in positions -511 and +3953) and ACS in the Turkish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 receptor antagonist gene polymorphism in Japanese patients with systemic lupus erythematosus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between interleukin-1 receptor antagonist (IL-1ra) gene polymorphism and early and late-onset psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that IL-1ra polymorphisms are not associated with the development of IgAN in Japanese patients but the presence of IL1RN*2 may be associated with increased disease activity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that these polymorphisms within IL1RN and IL1L1 themselves or a gene in linkage disequilibrium with IL1RN and IL1L1 predispose to the more severe forms of alopecia areata.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of polymorphisms in CTLA-4, IL-1ra and IL-1beta genes with multiple sclerosis in Serbian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Although ours and other published data on different samples of Caucasian and non-Caucasian AD show a great heterogeneity in the frequencies of the IL-1alpha(-889), the IL-1beta(-511) and the IL-1Ra VNTR gene polymorphisms, we confirm the role of the IL-1alpha(-889) T/T genotype as a risk factor for sporadic AD, and show the presence of an allelic association between IL-1beta C and IL-1Ra 1 alleles in both the Italian and the USA groups, confirmed by the presence of significant levels of linkage disequilibrium between these two loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in immunoregulatory genes: towards individualized immunosuppressive therapy?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of an interleukin 1B gene polymorphism (-511) with Parkinson's disease in Finnish patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 alpha polymorphism has influence on late-onset sporadic Parkinson's disease in Taiwan.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cerebral ischaemia is a potent stimulus for expression of genes that may influence recovery.We investigated whether functional polymorphisms in the apolipoprotein E (APOE), insulin-like growth factor-1 (IGF-1), tumor necrosis factor-A (TNF-A), interleukin-1A (IL-1A), interleukin-1B (IL-1B), and interleukin-6 (IL-6) genes are related with outcome after aneurysmal SAH.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results do not support the hypothesis that genetic variation in select polymorphisms of the IL-1 cluster genes is associated with aneurysmal subarachnoid cerebral hemorrhage. However, the IL-1beta gene may modify disease severity and may be regarded as disease severity gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[However, there are controversial findings from other studies which revealed no significant associations between these polymorphisms and AD; thus further evaluation of the association of IL-1 gene polymorphisms with AD and their role in pathogenesis is needed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are potent immunomodulators and proinflammatory cytokines that have been implicated in the pathogenesis of autoimmune and infectious diseases and proposed to be risk factors for LAgP.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To make investigations on the polymorphism of interleukin-1 (IL-1)gene in Chinese Han population, on its association with essential hypertension, and on the relationship between the genotype of IL-1 and susceptibility to essential hypertension.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present study suggests that genetic factors are associated with susceptibility to develop symptomatic dental abscesses.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association analysis of IL1A and IL1B variants in alopecia areata.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A comprehensive analysis of 207 SNP of 11 cytokine genes revealed that variations in IL-4 and IL-1RN genes are negatively associated with the risk of developing gastric cancer following H. pylori infection. Distinct host cytokine responses in the gastric mucosa might have a role in H. pylori-induced carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data do not provide evidence for an association between the polymorphic variants of the IL-1B and COMT genes and breast cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the present case-control study, we ascertained three polymorphisms of the IL1 gene cluster -889 C/T polymorphism of the IL1alpha gene (IL1A), -511 C/T polymorphism of the IL1beta promoter (IL1B promoter), a polymorphism of IL1beta exon 5 (IL1B exon 5), an 86-bp repeat in intron 2 of the IL1 receptor antagonist gene (IL1RN), and the -174 G/C polymorphism of the IL6 gene (IL6) in 269 patients with breast cancer and 227 healthy controls using PCR and pyrosequencing.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[TNF2 plays an important role in the susceptibility of cachexia in breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ None of the markers tested were shown to be associated with increased or decreased risk of RA. The rarer alleles of IL-4 VNTR and IL-1B (-511) appear to be associated with a less severe course in RA of long duration.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The purpose of this study was to evaluate whether IL-1 beta (IL-1beta promoter and IL-1beta exon 5), IL-1 receptor antagonist (IL-1 Ra), and IL-4 (IL-4 promoter and IL-4 intron 3) gene polymorphisms act as markers of susceptibility to Kawasaki disease (KD), or of the severity of the disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results suggest that the -511 CC genotype of the IL1B gene could be related to resistance to bisphosphonates in patients with PDB.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No association was found in either allele frequency or genotype distribution of IL1RN and IL1B polymorphisms between CAD and the control groups.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The interleukin-1 gene family in multiple sclerosis susceptibility and disease course.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Overexpression of the pluripotent cytokine interleukin-1 (IL-1) by microglial cells correlates with formation of neuritic beta-amyloid plaques in Alzheimer's disease (AD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Extensive, previous evidence (reviewed here) indicates an important role for noradrenaline in the control of inflammation in the brain. Thus, the -1021T allele with presumed low activity may be associated with misregulation of inflammation, which could contribute to the onset of AD. We suggest that such misregulation is the predominant mechanism of the association we report here.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The findings support the association of several loci with AD, and suggest how intermediate phenotypes can enhance analysis of susceptibility loci in this complex genetic disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results show statistically significant (p <or= 0.05) differences between genotype frequencies in aggressive and controls (IL-1B +3954 & IL-6 -174); chronic and controls (IL-6 -174 & VDR -1056); chronic and aggressive periodontitis (IL-1A -889); and periodontitis as a whole and controls (VDR -1056, TLR-4 399 & IL-6 -174).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To study whether interleukin-1 (IL-1) genotypes and/or alleles were associated with aggressive periodontitis (AgP).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A group of 20 subjects aged more than 35 with clinical and radiographic signs of severe periodontitis (cases) underwent the salivary genetic test to single out the alleles of the genes IL-1A and IL-1B, by the PCR technique.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[(1) There were no significant differences in the distribution of IL-1A-889 among severe CP patients, moderate CP patients, mild CP patients and healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results suggest that common genetic variants in proinflammatory cytokine genes could influence the risk for spontaneous preterm birth. Selected TNF/LTA haplotypes were associated with spontaneous preterm birth in both African-American and white subjects. Our data do not support an inflammatory etiology for SGA.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These studies identify single locus associations with preterm birth for both maternal and fetal genotypes in two populations of European ancestry.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Allele IL-1RN2 polymorphism, but not IL-1A or IL-1B gene polymorphism, is associated with susceptibility to sepsis. Alleles A2, B2 and RN2 might be important high-risk genetic markers for sepsis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our analysis of these SNP in the IL-1 complex and NF-kappaB genes does not support a major role for either in AS susceptibility in the Seoul and Toronto populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that these polymorphisms might confer a greater susceptibility to develop dysthymia in Brazilian patients. However, to validate these data it will be of great interest to repeat this study in larger samples and other ethnic groups.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The IL-1alpha-889 polymorphism, previously shown to predispose to increased IL-1 protein expression, may be involved in susceptibility to SSc.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To analyze the frequencies of haplotypes of single-nucleotide polymorphisms (SNPs) of the IL1A gene (at -889, +4729, and +4845) in patients with systemic sclerosis (SSc) and in healthy control subjects, and to determine whether the IL1A gene haplotype is associated with SSc susceptibility or disease severity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin (IL)1alpha and IL1beta, and their endogenous receptor antagonist (IL1Ra), have been related to the pathology of systemic lupus erythematosus (SLE), but the role of IL1 polymorphisms in the aetiology of SLE is unknown.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our findings suggest that the IL-1 gene cluster polymorphisms may play a significant role in the pathogenesis of OA of the hip.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 region meta-analysis with osteoarthritis phenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of interleukin-1 alpha gene polymorphism with cerebral infarction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Specific interleukin-1 gene polymorphisms in Turkish patients with Behet's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Diminished cell-mediated immune response, which is controlled genetically, appeared to be an important risk determinant of HBV-related hepatocellular carcinogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our data suggest an association of genetic variants in IL-6 and IL-2 with hayfever, confirm a role of polymorphisms in IL-4R, IL-13, and IL-18 for the elevated IgE phenotype, and add IL-6 to the list of candidate genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Haplotypes of the IL18 promotor region may contribute to CD risk, consistent with this cytokines role in maintaining inflammation in active CD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of the data within ethnic subgroups revealed a significant positive association of the heterozygous IL-18 GC genotype with ovarian cancer risk among Native Hawaiian women (OR: 9.96; 95% CI: 1.88-52.90).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We examined two single nucleotide polymorphisms of the IL-18 gene in 119 patients with sarcoidosis and 130 healthy control subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of single nucleotide polymorphism of interleukin-18 with atopic dermatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We showed that the rs438421 polymorphism in the IL-12RB1 (TT) gene and the rs2066446 polymorphism in the IL-12RB2 (AA) gene had a significant interaction to develop the ADe phenotype (allergic type of AD), and those individuals with the risk alleles, TT/AA/CC (IL-12RB1/IL-12RB2/IL-18), have more than a 10-fold increased risk to develop ADe.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Here, we investigated whether interleukin (IL)-18 single nucleotide polymorphisms (SNPs) are involved in Chinese asthma patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-18 promoter polymorphisms and the disease progression of Hepatitis B virus-related liver disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Disease association of two distinct interleukin-18 promoter polymorphisms in Caucasian rheumatoid arthritis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Prevalence of the -295 T-to-C promoter polymorphism of the interleukin (IL)-16 gene in periodontitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These findings suggest that variants C-1055T and Arg130Gln of the IL13 gene might play an important role on total serum IgE production in this study population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Several interleukin-4 and interleukin-13 gene single nucleotide polymorphisms among Chinese asthmatic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We further identified that asthmatic patients homozygous for the Gln110 variant have higher serum levels of IL-13 than those without the variant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The odds ratios (ORs) for the association between IL-2 polymorphism OR = 2.78, 95% CI (confidence interval) = 1.26-6.17 (T/T to G/G) or IL-4 polymorphism OR = 2.22, 95% CI = 1.01-4.89 (T/C to C/C) were increased significantly with gastric atrophy, whereas the corresponding OR of IL-13 polymorphism was decreased with gastric atrophy OR = 0.61, 95% CI = 0.39-0.96 (C/T and T/T to C/C).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that genetic polymorphisms in the 3'UTR of the IL-13 gene correlate with long-term outcome of MCNS, rather than disease susceptibility, in Singapore Chinese children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, our results suggest a possible involvement of IL-13 SNPs in the regulation of IgE production in response to allergens in this Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[An IL-13 promoter polymorphism associated with increased risk of allergic asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our aim was to assess relation between an IL12B promoter polymorphism and asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ In this long-term study of asthmatic subjects with comprehensive data on asthma severity, we found no evidence to support the presence of a heterozygote effect of the IL12B promoter polymorphism on the level of asthma in early childhood or adulthood. The polymorphism was also not associated with asthma susceptibility, but the CTCTAA allele may have been associated with elevated serum IgE levels in male subjects and reduced pulmonary function in female subjects in early childhood.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Replication of genetic association studies in asthma and related phenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings support the concept that an individual's genetically determined ability to produce IL-12 is another factor that can influence the outcome of HCV infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interestingly, IL12B promoter heterozygosity was associated with protection from tuberculosis in BCG-vaccinated individuals (p=0.03; OR=0.6).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of the IL12B and IL23R genes are associated with psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma cytokine gene polymorphisms in asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The chromosome 21q22.11 cytokine receptor cluster contains four genes that encode subunits of the receptors for the cytokines interleukin-10 and interferon-alpha, -beta and -gamma that may have a role in malaria pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Microsatellites (MS) at positions -4000 and -1200 (IL10R and IL10G, respectively) and single nucleotide polymorphisms (SNPs) (MS) at positions -1082G/A, -819C/T and -592C/A of the IL-10 promoter were analysed in patients with SLE and healthy controls from Canary Islands (Spain).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The analysis of combined genotypes of the studied genes suggests a synergic action of genes Fc gamma RIIIA and IL-10 on the risk to develop SLE.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A significant increase was found in SLE patients (0.170 versus 0.095; chi2y = 4.11, P = 0.0425) in the frequency of the 140-basepair allele of the IL10.G microsatellite located in the promoter region of the IL-10 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[DNA from 76 Caucasian patients with SLE and 119 controls as genotyped for 3 defined dimorphic polymorphisms (G or A at position -1082, C or T at position -819, C or A at position -592) in the promoter region of the IL-10 gene, using the polymerase chain reaction to amplify the IL-10 gene promoter and oligonucleotide probes specific for each allelic sequence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Recent studies have shown elevated IL-10 levels in several rheumatic autoimmune diseases, and particularly in systemic lupus erythematosus (SLE).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These findings suggest an association between the genetic ability to produce low levels of IFN-gamma and the susceptibility to develop chronic HBV infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There was no evident relationship between IL-4-590 C/T allele SNP and susceptibility to HBV intrauterine infection, but the IL-10-1082 G allele seemed to be associated with preventive efficacy to HBV intrauterine infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of cytokine genetic polymorphism with hepatitis B infection evolution in adult patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-10.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Single nucleotide polymorphisms and intragenic microsatellite markers within 8 candidate cytokine genes (interleukin-1alpha IL-1alpha, IL-2, IL-4, IL-6, IL-10, interferon-alpha1 IFNA1, interferon-gamma IFNG, and interferon regulatory factor 1 IRF-1) were investigated in 417 Caucasian patients with clinically characterized JIA and a panel of 276 unrelated, healthy Caucasian controls, all from the United Kingdom.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of non-HLA genetic polymorphisms in graft-versus-host disease after haematopoietic stem cell transplantation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Allele A of the Hsp70-2 gene may be associated with a less severe form of CD, suggesting the clinical value of the genotype assessment. The genetic determination of the defense mechanisms in CD appears to be associated with the polymorphism of the Hsp70-2 gene rather than that of the CD14 or IL-10 genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Juvenile idiopathic arthritis genetics - what's new? What's next?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The ATA (a non-GCC) haplotype, which is associated with low IL-10 expression, has been shown to improve interferon (IFN) treatment response in hepatitis C. We analysed the distribution of IL-10 promoter haplotype combinations to determine whether they could influence initial IFN treatment response in 63 patients with relapsing-remitting multiple sclerosis (MS).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[As a non-European patient population, according to our results, IL10 polymorphism is not associated with MS and its subtypes nor influences the disease progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results indicate that variants of the immunomodulatory IL10 and IL19/IL20 genes may be involved in natural clearance of HCV in the African-American population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In contrast, the different rates of interleukin-10 production associated with the interleukin-10 polymorphism did not affect susceptibility to tuberculosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Nevertheless, these findings suggest that the TNF-alpha -308 G/G and TGF-beta codon 10-25 T/T-G/C genotypes may be potential risk factors for RCC, whereas TNF-alpha -308 G/A, IL-6 C/C and TGF-beta1 codon 10-25 C/C-G/G genotypes may be possible protective factors. The number of the cases has to be increased to investigate the independency of these polymorphisms involved in the oncogenesis of RCC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin (IL) 1beta and IL-10 gene polymorphism in chronic hepatitis C patients with normal or elevated alanine aminotransferase levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To analyse the role of polymorphisms of the interleukin-10 promoter region in the epidemiologic, clinical and immunologic characteristics of patients with primary Sjgren's syndrome (SS).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of this study was to assess the relationship between polymorphisms involving five cytokine genes (TNF-alpha, TGF-beta, IL-10, IL-6, and IFN-gamma), and IBD susceptibility and disease phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin 10 promoter region polymorphisms in inflammatory bowel disease in Tunisian population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Psoriasis is not determined by a genotype consistent with high production of Th1 cytokines or low production of Th2 cytokines. Thus, the Th1 cytokine profile found in psoriatic plaques is most likely a consequence of local factors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of N-acetyltransferase 2, glutathione S-transferases T1 and M1, and promoter polymorphisms of the genes encoding for tumor necrosis factor-alpha and interleukin-10 were investigated in 151 Caucasian patients with psoriasis (100 with type I and 51 with type II psoriasis) and in 123 healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ These data suggest that variations in genes involved in immune regulation are associated with biologic and clinical phenotypes in the first year of life that might increase the risk for the subsequent development of childhood asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comprehensive characterization of genetic variation in extended cytokine candidate gene regions is now needed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, antigenic stimulation by HER-modified CYP2E1 combined with an impaired control of T-cell proliferation by CTLA-4 mutation promotes the development of anti-CYP2E1 autoantibodies that might contribute to alcohol-induced liver injury.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[No association was found between the previously implicated polymorphisms of TNF-alpha, IL-10, CD14 and MnSOD, either individually or simultaneously, and the presence of established ALD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Toll-like receptor signaling pathway variants and prostate cancer mortality.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin 10.G microsatellite in the promoter region of the interleukin-10 gene in severe sepsis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In the present study it was aimed to examine the IL-10 gene promoter region's polymorphic variants in patients with schizophrenia in a population of the Elazig Region of East Anatolia, Turkey.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The results of this preliminary study confirm that the pro-inflammatory IL-1B genotypes, as well as male gender, are risk factors for development of gastric cancer in Mexican population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest a contribution of the anti-inflammatory cytokines gene polymorphisms in sar- coidosis mainly in what susceptibility and clinical course is concerned. Key-wordgene polymorphisms, anti-inflammatory cytoki- nes, sarcoidosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results of our study support the hypothesis of a genetically encoded immune regulation imbalance in sarcoidosis. The high-producer IL-10 (-819) and (-592) CC genotypes and intermediate- producer IL-10 (-1082) (-819) (-592) ACC haplotype 2 present in the majority of our sarcoidosis patients could support the role of genetically encoded disregulation of cell- mediated immune response to an unknown antigen.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We suggest that dysregulation of both IL-6 and IL-10 in some elderly people, due in part to genetic variations in the two genes, contributes to the development of AD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have used immunohistochemistry, Western blotting, real time-PCR (RT-PCR) on frontal (BA 6/24) and temporal (BA 20-22) neocortex and hippocampus from AD and control brains as well as genetic association analysis to address the possible involvement of IL-10 in AD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Progression of periodontal disease and interleukin-10 gene polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Susceptibility to primary Epstein-Barr virus infection is associated with interleukin-10 gene promoter polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The most interesting result was the observed, significant shift to genotype AA of the IL-10 polymorphism in Wegener's granulomatosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5' regulatory region.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We analyzed 11 functional polymorphisms in tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1, IL-4 and IL-10 genes in 220 Taiwanese Chinese with GC and in 230 healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We believe that the associations of these genotypes with RPL are interesting not only as risk factors but also because they represent another piece of evidence that these cytokines might be important in the pathogenesis of RPL.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-10 promoter polymorphisms and atopic asthma in North Indians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Ig KM and GM genes do not contribute to susceptibility to pSS. The Ig KM1 allele is associated with several markers of immunologically active disease, whereas the Ig GM z allele is associated with milder pSS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, the IGFBP-3 -202 A/C polymorphism was not associated with susceptibility to PCa and BPH in Japanese men, but the presence of the C allele may cumulatively increase the risk for tumor metastasis and for having tumors with a biologically more aggressive phenotype. Because of the significant differences in incidence of clinically evident PCa according to racial backgrounds, the conjecture should be further examined in different racial populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Both IRS1 and IRS2 variants were associated with colon cancer risk independently. Associations were slightly stronger when polymorphisms in multiple genes were evaluated in conjunction with other genes rather than individually. These data suggest that the insulin-related pathway may be important in the etiology of colon cancer but not rectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IGFBP3 A-202C polymorphism and breast cancer susceptibility: a meta-analysis involving 33,557 cases and 45,254 controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Subjects carrying the heterozygous 167-bp IGF2R genotype had a 2.7-fold higher risk of oral cancer compared with subjects with other genotypes (odds ratio = 2.7, 95% confidence interval: 1.16-6.48), controlling for major confounders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Further studies are needed to explore contributions from other genetic factors such as rare variants in these genes and variation outside of these genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Using resources from the Flint Men's Health Study, a population-based case control study of African-American men aged 40-79, we evaluated the associations between selected single-nucleotide polymorphisms (SNPs) in the CYP17, CYP3A4, CYP19A1, SDR5A2, IGF1, and IGFBP3 genes and prostate cancer diagnosis in 473 men (131 prostate cancer cases and 342 disease-free controls).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We analyzed haplotypes and three haplotype-tagging single nucleotide polymorphisms (htSNPs) in the 3' region of the IGF-I gene in relation to circulating levels IGF-I in 698 control subjects from the CAncer Prostate in Sweden (CAPS) study and 575 cases and controls from the prospective Northern Sweden Health and Disease Cohort (NSHDC) study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lack of replication is common and could be due to differences in study design, phenotype, populations examined or the occurrence of false positives in the initial study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, these studies show an association between IGF-I markers and birth size alone, symmetrical SGA, low birth weight-only SGA, and short SGA phenotypes. This suggests that IFG-I genetic variation influences growth and metabolism in fetal and postnatal life.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We wanted to study if these polymorphisms or any haplotypes of the IGF1 and the IGFBP3 genes are associated with CRC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Insulin-like growth factor-I (IGF-I) is involved in colorectal carcinogenesis, and elevated plasma IGF-I levels are associated with sporadic colorectal cancer (CRC) risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the IGF1 CA repeat is an important modifier of disease onset in HNPCC and the first polymorphism to yield consistent results across different populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interferon-gamma and interferon-gamma receptor 1 and 2 gene polymorphisms and restenosis following coronary stenting.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The IFN-GammaR2 Arg64/Arg64 genotype does not determine susceptibility to SLE in Chinese people, and the combination of IFN-Gamma R2 Arg64/Arg64 genotype and IFN-Gamma R1 Val14/Val14 genotype does not, either.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The combination of polymorphisms within interferon-gamma receptor 1 and receptor 2 associated with the risk of systemic lupus erythematosus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of the interferon-gamma receptor variant (Val14Met) with systemic lupus erythematosus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results demonstrate that common polymorphisms in the IFNgamma/IL-26 gene region may contribute to sex bias in susceptibility to RA, by distorting the propensity of female carriers versus male carriers to contract this disease. These results conform to our recent observations of a role for this gene cluster in sex-based differential susceptibility to another Th1-type inflammatory disease, multiple sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of, rheumatoid arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IFN- gamma 3/3 was found to be associated with an increased risk of chronic graft-versus-host disease (GvHD) (11/27 vs 26/133, p=0.02). Forward logistic regression analysis confirmed the role of IFN-gamma 3/3 genotype as one of the risk factors for manifestation of chronic GvHD (OR=3.180, p=0.018) together with previous acute GvHD (OR=2.752, p=0.024), cyclosporine A monotherapy (OR=2.607, p=0.029) and malignant disorders (OR=4.371, p=0.032).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Combined association between IFN-gamma 3,3 homozygosity and DRB1*03 in Lfgren's syndrome patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our results suggest an association with IL-4 gene polymorphism that is dependent on HLA-DRB1 genotype in GCA susceptible individuals. These data indicate an interaction between HLA-DRB1 and IL-4 that contributes to pronounced disease susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, no significant association was observed between the +874 T/A polymorphism found in the first exon of the IFN-gamma gene and TB susceptibility in Turkish children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interferon-gamma is the most important cytokine in resistance to mycobacterial diseases and common variants of interferon-gamma gene could be related to tuberculosis susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genotypes of SNPs of pro-inflammatory cytokines, tumour necrosis factor-alpha -308G -->A, interleukin-6 (IL-6) -174G -->C and interferon-gamma +874G -->A, and anti-inflammatory, immunosuppressive cytokines, interleukin-10 -1082G -->A, -819C -->T and -592A -->C and transforming growth factor-beta1 (TGF-beta1) codon 10T -->C and codon 25G -->C, were determined for patients with JRA who previously participated in a long-term outcome study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ To our knowledge, this study is the first to demonstrate the possibility that the IL-4 promoter gene -589 T gene polymorphism with increased IL-4 synthesis in combination with IRF-1 allele 1 confers host genetic susceptibility to SSPE in Japanese subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data provide a starting point for functional and genetic analysis of the IFNG genomic region in malaria and other infectious and inflammatory conditions affecting African populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our findings indicate that heterogeneity in the promoter region of the IL-10 gene has a role in determining a spontaneous favourable outcome of HCV infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In coeliac disease (CD) a profile of proinflammatory cytokines are secreted interferon gamma (IFNgamma) being one of the most important.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings provide strong evidence of which IFN-gamma CA repeat and IRF-1 GT repeat polymorphisms influence the risk of asthma for children in Taiwan.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings suggest that STAT-4 T90089C and IFN-gamma T874A polymorphisms might be the genetic factors for the risk of asthma in the Chinese population. In addition, the significant interactions among STAT-6 G2964A, STAT-4 T90089C and IFN-gamma T874A may increase an individuals susceptibility and contribute to the pathogenesis of asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aims of the current investigation were to determine whether functional polymorphisms in the tumor necrosis factor-alpha (TNF-alpha) gene at positions -308 and -238; in the transforming growth factor-beta 1 (TGF-beta(1)) gene at positions -509, +869 (codon 10), and +915 (codon 25); in the interleukin-10 (IL-10) gene at position -1082; and in the intron 1 of the interferon-gamma (IFN-gamma) gene at position +874 are associated with alcoholic chronic pancreatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[It could be suggested that the genetic variation in IL-12 A/C (-1188) and IFN-gamma A/T (+874) cytokine genes could be risk factors for MS patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of linkage and association of alleles of proinflammatory cytokines genes IL-6, IFNg and TNF with multiple sclerosis using transmission disequilibrium test (TDT).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To explore the relationship between cytokines (tumor necrosis factor-alpha, interferon-gamma, interleukin-4 and interleukin-10), which expressed abnormal quantity in the peripheral blood to intrauterine hepatitis B virus infectious children, gene single nucleotide polymorphism (SNP) and susceptibility to hepatitis B virus intrauterine infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ This study suggested the possibility that TNF-alpha-238 A allele and IFN-gamma + 874 A allele were associated with HBV intrauterine infection. There was no evident relationship between IL-4-590 C/T allele SNP and susceptibility to HBV intrauterine infection, but the IL-10-1082 G allele seemed to be associated with preventive efficacy to HBV intrauterine infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional IFNG polymorphism in intron 1 in association with an increased risk to promote sporadic breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[further studies involving larger numbers of subjects are required.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Given that the production of IFN-gamma and IL-4 are under genetic control, we investigated the relationship between these two cytokine gene polymorphisms and the susceptibility to brucellosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[TNF-alpha, TGF-beta, IL-10, IL-6 and IFN-gamma gene polymorphisms as risk factors for brucellosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interferon-gamma polymorphisms correlate with duration of survival in pancreatic cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[But these SNPs did not show a clinical significance, as compared with the GT-repeat in IFNAR1, in the context of interferon responsiveness.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ This preliminary result suggests that the promoter GT repeat dinucleotide microsatellite polymorphism of the IFNAR1 gene may represent a risk factor for the development of depressive symptoms during IFN-alpha therapy for hepatitis C and other conditions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results of this study suggest that the 184Ile homozygote of the IFNA17 gene may represent an important susceptibility biomarker for cervical cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two-fold increased risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Combined risk effects of IDE and NEP gene variants on Alzheimer disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The effect observed was found to be strongest among the HLA-DQB1*0602-positive subjects, which implies genetic heterogeneity of MS. Meta-analysis of all published datasets supports increased risk of MS for the ICAM-1 Lys(469) homozygotes (relative risk = 1.3, p = 0.002).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymerase chain reaction-sequence specific primers (PCR-SSP) technology and PCR-restriction fragment length polymorphism(PCR-RFLP) were used for the detection of ICAM-1 genotypes in 165 patients with MI(including acute MI and old MI) and 199 healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional genetic variants in cytokine and leukocyte-endothelial interaction pathways are independently associated with severity of myonecrosis after cardiac surgery. This may aid in preoperative identification of high-risk cardiac surgical patients and development of novel cardioprotective strategies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evidence from autopsy and in vitro binding studies suggests that adhesion of erythrocytes infected with Plasmodium falciparum to the human host intercellular adhesion molecule (ICAM)-1 receptor is important in the pathogenesis of severe malaria.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In a study sample specifically selected for the characteristic of a family history of premature coronary heart disease, ICAM K469E GG was associated with lower CAC scores in men but not women even after controlling for plasma levels of sICAM-1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ In conclusion, contemporaneous carrier-state of two or three polymorphic variants within analyzed genes is associated with CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[There is the polymorphism of ICAM1 K469E gene in Han population of China, and the K allele may be a genetic factor influencing the risk of CHD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We hypothesize that the biochemical effect of the G241A SNP is masked in schizophrenic patients, indicating a disease-related mechanism leading to reduced levels of sICAM-1 in schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In proliferative diabetic retinopathy (PDR) increased levels of cytokines, inflammatory cells and angiogenic factors are present.These factors increase the expression of cellular adhesion molecules (CAMs)The objective of this study was to investigate the association between the polymorphisms of the ICAM-1 gene (K469E, G241A) and the development of PDR among patients with type 2 diabetes in the Slovenian population (Caucasians).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our aim was to investigate the prevalence of polymorphisms in NOD2, ICAM-1 and CCR5 genes in Czech and Slovak patients with IBD in comparison with healthy controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To assess the associations between schizophrenia and six functional genes: dopamine D2 receptor gene (DRD2), dopamine D4 receptor gene (DRD4), 5-hydroxytryptamine 2A receptor gene (5-HT2A), 5-HT6 receptor gene (5-HT6), catechol-O-methyltransferase gene (COMT) and dopamine transporter gene (DAT1).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, the 5HT(6) receptor gene variant can affect risperidone response to positive symptoms and general psychopathology (but not negative symptoms) after control for nongenetic factors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggest that the HTR6 polymorphism C267T possibly involved in the susceptibility to LOAD as an APOE varepsilon4-allele independent risk factor of LOAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These polymorphisms probably do not represent major genetic risk factors of AD. However, further studies including other genetic variants of the serotonergic neurotransmitter system are needed in order to elucidate their role in AD. ]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, we evaluated the association of seven serotonin signal transduction-linked single nucleotide polymorphisms HTR1A (rs6295), HTR2A (rs6313, rs6311 and rs7997012), HTR6 (rs1805054), TPH1 (rs1800532) and TPH2 (rs1386494) with major depressive disorder and/or treatment outcome with serotonin reuptake inhibitors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that genomic variations in the HTR4 gene may confer susceptibility to mood disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Of these, four polymorphisms at or in close proximity to exon d, g.83097C/T (HTR4-SVR (splice variant region) SNP1), g.83159G/A (HTR4-SVRSNP2), g.83164 (T)9-10 (HTR4-SVRSNP3), and g.83198A/G (HTR4-SVRSNP4), showed significant association with bipolar disorder with odds ratios of 1.5 to 2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings show that the C178T(Pro16Ser) variant in HTR3A may represent a functional variant and affect the susceptibility to bipolar disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The present results suggest that the HTR3A and DBH genes may participate in the regulation of dopamine and serotonin turnover rates in the central nervous system.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To determine whether 5-hydroxytryptamine 2C (5-HT2C) receptor gene 759C/T polymorphism influences the weight gain following antipsychotic agents (APS) treatment in patient with schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A haplotype analyses between the (GT)12-18/(CT)4-5 motif and a Cys23Ser variant of the 5-HT2C gene (which had previously been genotyped in the same sample) showed similar distributions between cases and controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association studies of 5-HT2A and 5-HT2C serotonin receptor gene polymorphisms with prophylactic lithium response in bipolar patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[the results indicate a possible association between 5HT2C and alcohol use disorder comorbidity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that sequence variation in the BACE1 or BACE 2 gene is not a significant risk factor for AD; however, a combination of a specific BACE1 allele and APOE varepsilon 4 may increase the risk for Alzheimer disease over and above that attributed to APOE varepsilon 4 alone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data extend the evidence that HTR2C promoter variation may be a risk factor for obesity and, perhaps through heterosis, influences weight loss by obese women. Pharmacogenetic testing of HTR2C promoter variants may be valuable when evaluating anti-obesity drugs which act directly or indirectly on the receptor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genes involved in the transmission, reuptake and metabolism of serotonin constitute a set of candidate genes that could be involved in core aspects of alcoholism, such as the tendency to prefer immediate reward, despite negative consequences.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The clinical and socio-demographic characteristics were not significantly different between the two groups; the genetic analysis revealed a significant correlation between the C/C genotype of 5-HT2A and TD (p=0.017).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The objective of this study was to determine association of T102C and His452Tyr polymorphisms in the 5-HT(2A) receptor gene (HTR(2A)) with TD in a large, multicentre patient sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results of this study suggest that response in venlafaxine-treated OCD patients is associated with the S/L genotype of the 5-HTTLPR polymorphism and in paroxetine-treated OCD patients with the G/G genotype of the 5-HT2A polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therefore, we conducted a case-control study with Japanese samples (738 schizophrenia patients, 196 methamphetamine-induced psychosis patients, and 802 controls) to evaluate the association and interaction between GRM2, HTR2A and schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conducted a pharmacogenetic study to evaluate whether variants in dopamine-related genes (DRD1-DRD5, AKT1 and GSK3beta) and serotonin receptor genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR2C, HTR6 and HTR7) can be used to predict the efficacy of risperidone treatment for schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Serotonin receptor (5-HTR2A) and dysbindin (DTNBP1) genes and component process variables of short-term verbal memory in schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Some studies have suggested that the efficacy of atypical antipsychotics on schizophrenia treatment may be related to the serotonin 2A receptor (5-HT2A), and that serotonergic drugs may induce psychotic symptoms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Here we report the results from an association candidate-gene approach, where we analyzed 15 single nucleotide polymorphisms (SNPs) within the gene coding for the serotonin-receptor 2A (HTR2A) in patients suffering from PD and a control sample.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T-C, CCKR1 246G-A, CCKR2 -215C-A, DRD1 -94G-A and COMT Val158Met, were selected for genotyping based on previous positive findings from genetic association studies in PD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study reinforces the association between HTR1A and PD. No major evidence of gene-environment interaction in PD with parenting or trauma was found. Further studies are necessary in order to confirm these findings.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, the polymorphic alleles of SHTR2A proved to be associated with personality traits in mentally healthy people.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of the present study was to test for possible associations between the A-1438G polymorphism in the serotonin receptor gene (HTR2A) with tobacco smoking combined or not with alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, although our findings cannot specifically refute the hypothesis of Du et al. that genetic variation in the 5-HT2A receptor gene is associated with increased vulnerability to suicidal ideation in those with major depression, they certainly do not support the more important hypothesis that such a genetic variation is associated with completed suicide itself.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The association detected in this study suggests that the 5-HT(2A) receptor gene may play a role in the genetic susceptibility to bipolar disorder, through a specific subgroup of bipolar type I patients with lower risk of suicidal behavior.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hyperserotonemia in autism: the potential role of 5HT-related gene variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To determine the influence of genetic variation at the 5-HT(2A) receptor (T102C polymorphism) and the 5-HTT (insertion/deletion polymorphism) on the risk of developing early MI, we genotyped 210 MI patients of < 55 years old and 238 healthy control subjects for DNA polymorphisms in these genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Fine mapping of the human 5-HTR2a gene to chromosome 13q14 and identification of two highly polymorphic linked markers suitable for association studies in psychiatric disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A family-based association study of the 5-HT-1Dbeta receptor gene in obsessive-compulsive disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of a 5-HT1Dbeta receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Taken together with recent observations, these results suggest that genetic variability of the 5HT1B receptor is involved in the development of some type of alcohol dependence.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings indicate that genetic variants conceivably related to lower 5-HT neurotransmission may be involved in the development of PD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This is the first possible interaction of genetic variations in panic disorder that has been observed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The 5-HT1A receptor gene is repressed by NUDR/DEAF-1 in raphe cells at the C-, but not at the G-allele of the C(-1019)G polymorphism that is associated with major depression and suicide.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our data provided no evidence of association between schizophrenia and the variants in the 5' untranslated region as well as the coding region of the human 5-HT1A receptor gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association evaluation by Fisher's exact test (p < 0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our data show that the bi-allelic NcoI and PstI polymorphisms within the HSP70-HOM and HSP70-2 locus, respectively, are associated with neither susceptibility to nor outcome of severe sepsis. Moreover, we found a linkage between HSP70-2 A homozygotes and the previously reported and mortality-related homozygous genotype, TNFB2/B2, in patients suffering from severe sepsis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We previously investigated a group of single-nucleotide polymorphisms of a set of genes coding for heat shock proteins (HSPA1A, HSPA1B and HSPA1L) and found a significant association between one HSPA1B variation and schizophrenia (SZ).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ There is a significantly increased association of HSP70-2 B/B genotype with the risk of acute mountain sickness. Individuals with HSP70-2 B/B genotype may have weaker adaptive ability than those without this genotype under altitude stress. The results contribute to provide scientific bases for finding these individuals in specified occupational people, ensuring their health and enhancing work efficiency.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In contrast, a significant relative risk of NPC was found associated with the HSP70-2 homozygous genotype (P2/P2) (OR=2.309; P=0.006).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have investigated the association of polymorphisms -110 A/C, +190 G/C, +1267 A/G, +2074 G/C, and +2437 G/C in the 5' and coding regions of the HSP70-1, HSP70-2, and HSP70-hom genes with the risk of PD by screening DNA samples from 274 PD patients and 183 controls in assays based on the polymerase chain reaction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In addition to the association of SpA with HLA-B27, there is a significant association of HSP70-2 and HSP70-hom alleles with SpA in Mexicans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Men with the variant genotypes at either B1-N367T or B2-c7519g had a significantly higher risk to develop prostate cancer, especially the hereditary type of prostate cancer. Most importantly, the subset of hereditary prostate cancer probands, whose families provided evidence for linkage at 1p13, predominantly contributed to the observed association. Additional studies are warranted to confirm these findings.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therefore, our results indicate that the BAT-40 containing region and to a less extend the thyroid hormone receptor-alpha1 gene are related to thyroid cancer susceptibility. To our knowledge, this is the first study reporting the identification of genetic factors for thyroid cancer susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A total of 275 EH patients and 286 controls were genotyped for four SNPs of the HSD3B1 gene (rs3765945, rs3088283, rs6203, and rs1047303) and for two SNPs of the HSD3B2 gene (rs2854964 and rs1819698).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Our data are consistent with a plausible role of the G289S SNP in prostate cancer susceptibility. Therefore, the HSD17B3 gene may be a plausible candidate gene for prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have also sequenced a selected material of 37 sporadic cases of more severe hypospadias for mutations in the androgen receptor AR, SRD5A2, and 17beta-hydroxysteroid dehydrogenase HSD17B3 genes and found only two previously described mutations, one in the AR and one in the SRD5A2 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[it is unlikely that common genetic variation in HSD17B1 is associated with a moderate modulation in breast cancer risk overall; however, we cannot exclude the possibility of a very weak effect.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of HSD11B2 polymorphisms in essential hypertension and the diuretic response to thiazides.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic association of 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) flanking microsatellites with essential hypertension in blacks.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[over-representation of individuals homozygous for the G534 allele in hypertensive patients compared with control subjects suggests that a mutation in linkage disequilibrium with the G534A polymorphism could increase susceptibility to primary hypertension]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have concluded that the participation of these variants in the disorder is unlikely, particularly in view of their apparent lack of function and unlikely influence on receptor expression. However their nature alludes to the potential presence of other more important alterations further along these regions, where sequences encoding alternate promoters have recently been identified for each receptor that may yet be found to harbour such polymorphisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Low-penetrance genes and their involvement in colorectal cancer susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ K- ras gene mutations occur in chronic pancreatitis and are associated with evolution towards PAC. The absence of pancreatic calcifications and the presence of exocrine insufficiency were identified as additional predictive factors for the development of PAC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We conclude that individuals harboring the homozygous 81C-genotype of the H-ras proto-oncogene are at an increased risk of bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Frequency of active ras oncogenes in human bladder cancers associated with schistosomiasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of this study w trial randomized as to investigate the frequencies of human papillomavirus (HPV) and mutation in Ha-ras oncogene and tumour suppressor p53 gene in cervical cancer and precursor lesions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multivariate logistic regression analysis with adjustment for age, body mass index, presence of hyperlipidemia, diabetes mellitus, and current smoking and drinking revealed that one single nucleotide polymorphism (SNP), IMS-JST126186, in HPCAL1 (hippocalcin-like 1) in women and two SNPs, IMS-JST149391 and IMS-JST149390, in GREB1 (gene regulated by estrogen in breast cancer 1) in men were significantly associated with both prevalence of hypertension and blood pressure levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[in contrast to the findings from cross-sectionally based studies, the results from this longitudinal study show that Hp 1-1 individuals are at elevated risk for CHD mortality.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results suggest that haptoglobin phenotype is an important risk factor in determining susceptibility to cardiovascular disease in obstructive sleep apnea syndrome, which may be mediated by the decreased antioxidant and antiinflammatory actions of the haptoglobin 2 allelic protein product.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These findings suggest that combination of several polymorphisms in the enzymes that activate or detoxify the tobacco smoke, such as EPHX1 and HMOX1, might be associated with its affects on the development of emphysematous changes of the lung.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of an intronic variant of the heme oxygenase-1 gene with hypertension in northern Chinese Han population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The HO-1 promoter genotype that controls the degree of HO-1 up-regulation in response to stress stimuli is associated with the postintervention inflammatory response and the restenosis risk after balloon angioplasty.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes in a Chinese population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene-gene interaction between heme oxygenase-1 and liver X receptor-beta and Alzheimer's disease risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Acute intermittent porphyria (AIP), resulting from a deficiency of porphobilinogen deaminase (PBGD) in heme biosynthesis, is genetically heterogeneous and manifests with variable penetrance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus we provide the first evidence for a possible role of HLA-G in genetic susceptibility to, and pathogenesis of pre-eclampsia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ The allele frequencies of HLA-E are 42.29% for E*0101, 24.88% and 32.84% for E*01031 and E*01032 respectively in Shanghai Chinese. No extensive linkage disequilibrium was found between HLA-E and HLA-A or -B locus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our study provides the first demonstration of the association of the polymorphism of the MHC2TA gene with genetic risk for AAD that appears to be independent from the well-known association with the polymorphism of HLA class II genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ Alleles HLA-DR6 (13) were significantly implicated in their susceptibility to GDM. Conversely, HLA-DR2 (15), HLA-DR51 alleles might confer protection against GDM. HLA-DR3 gene and HLA-DR6 (13)/DR9 heterozygote were associated with severity and prognosis of GDM. It may be a marker of grade and prognosis of GDM and may direct the treatment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms of genes in the human leukocyte antigen (HLA) complex, particularly those encoding HLA-DR, have been suggested as markers of susceptibility to Kaposi's sarcoma (KS).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[HLA-DRB1 * 0301.2 and HLA-DRB4 * 0101 alleles might confer protection against AR.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The allelic frequencies of HLA-A*30, Cw*06, DRB1*07, and DQB1*0201 were increased significantly in generalized vitiligo and especially in the patients without family history compared with the controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Furthermore, we also found suggestive epistatic effect between rs2269577 and HLA-DRB1*07 allele on the development of vitiligo (p = 0.033).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Our findings suggest that DRB1*03, DRB1*04 and DRB1*07 alleles are genetic markers for general susceptibility to vitiligo in a Turkish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Susceptibility to type 1 autoimmune hepatitis is associated with shared amino acid sequences at positions 70-74 of the HLA-DRB1 molecule.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Comparison with other ethnic groups revealed that DRB1*0301 and *1301 related DRB1-DRB3 haplotypes vary among different populations, in that Koreans and other Asian populations show less diversity compared with Caucasoids or African Americans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[were compared with those of 36 female control subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The 8.1AH and 35.2AH may confer susceptibility to sIBM independently or share a critical allele.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Identical results were obtained with all samples. This new method also reduced ambiguous results and was faster and less cumbersome than currently used PCR-SSP or PCR-SSO techniques.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A total of six DRB1*03 alleles out of 21 known alleles were detected. DRB1*03011 was the predominant DRB1*03 allele in all populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Results showed associations with psoriasis vulgaris: positive associations HLA-DRB3*02 (p < 0.05, chi(2) = 5.10, RR = 2.14); HLA-DRB1*0102 alleles (p < 0.05, RR = 5.44).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Polymorphisms in the TNF-alpha SNPs do not seem to be a more important genetic risk factor for psoriasis than the already known Cw*06 in Brazilian patients, but these markers may be related to clinical manifestations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA Cw*0602 and DRB1*0701 were represented in different reports, and the former was related mainly to psoriasis type I.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Our results do not support the assumption that CTLA4 influences susceptibility to MS in European Caucasians. On the other hand, they raise the possibility that the development of MS in other ethnic groups involves interaction between CTLA4 and DR2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ Our data are consistent with those of Japanese studies in that DR2 and DRB1*1502 are positively associated with UC patients. In contrast to the Japanese study, however, our results demonstrates that DRB1*1502 is negatively associated with the risk of colectomy in Korean patients with UC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We confirmed the association of multiple loci with UC in the Dutch population and found evidence for association of 10q26 and a trend suggesting association for GAS7.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ These findings suggest that 1 or more other loci besides the HLA-DRB1 or other DRB1 (non-shared epitope, non-*0901) alleles are involved in RA susceptibility/protection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[This study represents the first molecular report on the HLA class II allele frequency in the population of Saudi Arabia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These findings furnish a genetic `portrait` of the populations of the analyzed regions that will be useful not only for investigation of the genetic risk of type 1 diabetes mellitus in Italy but also for studies of other autoimmune diseases related to HLA genotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These findings suggest a possible association of the DRB1 allele with the group of patients showing an early onset of the illness, as well as an association with haplotypes HLA-DRB1*0102/DQB1*05 and HLA-DRB1*0701/DQB1*03.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The aim of this study was to investigate a possible correlation between the HLA-DQA1 and HLA-DQB1 genetic markers and clinical features of celiac disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The results show that HLA-DRB1*03, HLA-DRB1*07, and HLA-DQB1*02 alleles conferred susceptibility to CD in Brazilian patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We can conclude that the distribution of DQ genes in the Saharawi population only provides a partial explanation for the high prevalence of CD. Other factors, such as rapidly changing dietary habits and/or non-DQ genes, may also play some role.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The phenotype and gene frequencies of B*4408 were 0.01235% and 0.00006, respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The data show genetic evidence suggesting that, in Colombians, a region immersed or in the vicinity in the HLA class II system is strongly associated with a predisposition to acquire pSS, which is probably located between the TAP2 and HLA-DQB1 locus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A positive association was observed between the existence of HLA-DQB1* 0601 and squamous cell carcinoma of the cervix (p<0.04, RR=1.94).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[For this purpose, HLA-A and HLA-B serotyping and HLA-C, HLA-DRB1, and HLA-DQB1 genotyping by polymerase chain reactions using sequence-specific oligonucleotide (PCR-SSO) and sequence-specific primer (PCR-SSP) were performed in 174 melanoma patients and 227 ethnically matched controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[In a 3-year follow-up study, results showed significant differences between groups of patients selected according to clinical stage, histology, and progression of the disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ These results suggest that particular HLA alleles may have an influence on chronic HCV infection as a host genetic factor in the Korean population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ Chronically infected HCV patients with symptomatic mixed cryoglobulinemia display a number of unique characteristics that differentiate them from asymptomatic patients with chronic hepatitis C.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Subtle differences in HLA DQ haplotype-associated presentation of AChR alpha-chain peptides may suffice to mediate myasthenia gravis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association of HLA-DQA1*0101/2 and DQB1*0502 with myasthenia gravis in southern Iranian patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ The polymorphism of HLA class II may influence the susceptibility to HBV infection and the response to IFN in studied CHB patients. Compared with other HLA-DRB1 alleles, HLA-DRB1*06, DRB1*08, and DRB1*16 may be associated with chronicity of HBV infection, HLA-DRB1*07 with protection against HBV infection, and HLA-DRB1*14 allele may be associated with a high rate of the response of CHB patients to IFN treatment. Compared with other HLA-DQB1 alleles, HLA-DQB1*07 may be associated with low response rate to IFN.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[In the whole, using PCR-based genotyping methods for HLA class I and class II loci, this study allows a preliminary description of HLA allele distribution in this Caribbean island and gives new elements which may be helpful in the anthropologic field as well as in HLA and disease association studies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These findings provide evidence of cytokine gene epistasis in SLE susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ Based on modern DNA techniques the present study shows an association of HLA to both RPP and AP. Certain HLA alleles seem to be associated with susceptibility or resistance to periodontitis in general. However, before this knowledge can be used for differential diagnosis or prognosis, further investigations are necessary.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ The present study elucidates the variety of HLA associations and therefore the difficulty to assign single HLA markers to periodontal disease. Susceptibility/resistance of both aggressive and chronic periodontitis may rather be influenced by particular HLA marker combinations. Associated HLA haplotypes may be of further importance for unknown gene loci representing a part of the genetic background for periodontitis. The different associations in aggressive and chronic periodontitis indicate different susceptibility/resistance factors for both diseases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These results suggest that a gene, or genes in the class I region are important in the initiation of the autoimmune cascade. Activation/suppression of these genes might act as the trigger mechanism that starts the autoimmune destructive process.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Our data suggest that among the western Indian population, certain HLA alleles or associated haplotype influence HCV infection as a host genetic factor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Most Kuwaiti Arab patients with OA-JIA who carried a DQ or DP susceptibility allele also had an accompanying DRB1*03 or *8 allele.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ The negative associations of a particular bcr-abl transcript with specific HLA alleles suggests that these alleles play a critical role in presenting peptides derived from the chimeric proteins and eliciting a successful T-cell cytotoxic response. Knowledge of differential associations between HLA phenotypes and bcr-abl fusion transcript types would help in developing better strategies for immunization with the bcr-abl peptides against t(9;22) (q34;q11)-positive leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA class II allele and haplotype frequencies in iranian patients with acute myelogenous leukemia and control group.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Further analysis suggested that susceptibility/resistance encoded by the second and third susceptibility haplotypes and by the two resistance haplotypes may be determined by specific amino acids at DQbeta-87 and DQbeta-55, respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ Co-amoxiclav associated hepatotoxicity may have a genetic basis and be delayed, severe, and prolonged, although complete recovery is usual.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Taken together with the previous report which demonstrated the association of the same haplotype in Taiwan, our present observations strongly suggested that DRB1*1502 - DQB1*0501 is the major HLA haplotype that confers susceptibility to SLE in the South-east Asian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Increased frequencies of DR2 in the overall SSc group (OR = 2.4), DRB1*0301 in the limited cutaneous SSc (lcSSc) subset (OR = 9.0), and DQB1*0301/4 in the diffuse cutaneous SSc (dcSSc) subset (OR = 9.0) were observed.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A significant increase in the +49A was not observed in SSc with HLA-DRB1*1502 or ORB1*0802.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA-DR gene has a primary association with anti-topo I response, and HLA-DR 38V-67FLEDR71 group alleles including DRB5*0102 (in linkage disequilibrium with DRB1*1502) show the strongest association with anti-topo I response in Korean patients with SSc.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA-DQB1*0503 allele and *0303 allele are independently resistant genetic factors to chronic hepatitis B, and alcohol consumption is the risk factor of chronic hepatitis B.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ This is the first report describing the haplotype DRB1*1502, DQB1*0601, DQA1*0103 in narcoleptic patients (non-cataplectic). This haplotype is close but different from the already known narcoleptic haplotype DRB1*1501, DQA1*0102, DQB1*0602. We assume that this haplotype represents a variant of non-cataplectic narcolepsy rather than association with hypersomnolence. However, in order to conclude whether this haplotype is a marker for the lack of cataplexy, or represents a variant of non-cataplectic narcolepsy, a larger group of patients should be investigated.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA DQB1 genotyping in latent autoimmune diabetes of adults (LADA).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Many of the HLA-DQ associations previously documented in non-Hispanic White populations also are found in African Americans and Latinos with DM1, although some differences exist.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These alleles associated with protection against type 2 diabetes, share glutamic acid at position-74 and were previously demonstrated to contribute to protection against type I diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[In conclusion, TNFalpha is unlikely to be the second gene in the HLA area responsible for our previous findings in type 1/2 patients. However, we could show an association between TNFalpha(308) polymorphism and the phenotype of common type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These results highlight the role of the CTLA-4 locus, in addition to HLA, in the susceptibility to GD. Inside the CTLA-4 region, CT60 appears to be the most associated polymorphism to GD, however, further studies are needed to identify the etiologic variant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The association between HLA class II haplotype with Graves' disease in Thai population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We conclude that in IDDM/ATD families, IDDM-affected subjects are at risk for ATD, especially those carrying DQB1*0201. This risk may be influenced by the alleles carried on the second haplotype, with DQB1*0302 (or a closely linked gene) protecting from Hashimoto's thyroiditis and favoring Graves' disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Relatively few epidemiologic studies have focused on narcolepsy, a disabling sleep disorder with a strong association with HLA-DQB1 *0602.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The association of narcolepsy with HLA-DQB1*0602 is established in Japanese, African-Americans, European, and North American Caucasians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[ The results indicate that the DRB(1) * 09 allele is susceptive to the pulmonary tuberculosis complicated with type 2 diabetes mellitus, the DQB(1) * 05 may be protective to the pulmonary tuberculosis complicated with diabetes mellitus. The DRB(1) * 09 allele and DQB(1) * 05 allele may affect the incidence of the pulmonary tuberculosis complicated with type 2 diabetes mellitus, or real effect genes link with them.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[common African HLA-DRB1 and -DQB1 variants, previously associated with protection from malaria and hepatitis B/C virus persistence, predispose the Venda to TB, whereas the proposedly active VDR haplotype F-b-A-T showed significant protection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[These results suggest that the natural history of cutaneous HPV 2/27/57-induced common warts may be modulated by allele polymorphisms at the HLA-DQA1 and HLA-DQB1 gene loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genotyping control showed a high risk of RF and RHD in patients with DRB1*01-DQB1*0301-DRB1*07-DQB1*0302 and DRB1*15-DQB1*0302-DRB1*07-DQB1*0303.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Our results are not in favor of a direct involvement of the HLA system in development of schizophrenia, but are compatible with the possible existence of a susceptibility gene in the MHC region at chromosome 6p 21.31.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The authors attempted a replication of an earlier study of African-Americans, in which they detected a negative association of schizophrenia with HLA DQB1*0602.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association of HLA-DQA1 and DQB1 alleles with alolpecia areata in Chinese Hans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[HLA-DQA1 * 0104 allele and HLA-DQB1 * 0201 allele were implicated in susceptibility to asthma and atopy, HLA-DQA1 * 0301 allele and HLA-DQB1 * 0301 might be protective factor against asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Evaluation of HLA class II gene products in TDI-induced asthma cases showed a positive association with HLA-DQB1 * 0503 and a negative association with HLA-DQB1 * 0501 alleles, which differed at residue 57 for a single amino acid, i.e.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Are HLA DQB1 alleles correlated with breast cancer histopronostic parameters in Tunisia?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.