RATpbjbDsEMFCTaXCNuTC63UWBPC8YKeX4A7eiZ W2jxo
has assertion: p(HGNC:BIRC5) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.386+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:BIRC5) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18075512

BEL Framework Large Corpus Document
description: Approximately 61,000 statements.
rights: Copyright (c) 2011-2012, Selventa. All rights reserved.
authored by: Selventa
version: 1.4

3
value: from full text - survivin is one of the most tumour-specific molecules (19), which antagonizes apoptosis (7), promotes tumour-associated angiogenesis (20) (BIRC5 = survivin)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18075512

RAdWAq8coiQKY1XPbQyT9mo87mzTKDAFVi-6kSy5sJp2A
has assertion: p(HGNC:AIP) -> p(HGNC:BIRC5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.387+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:AIP) -> p(HGNC:BIRC5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18075512

4
value: from full text - the aryl hydrocarbon receptor-interacting protein (AIP)56, and HSP90 (Ref . 57), which participate in survivin stability
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18075512

RAdEZm4E18Uv5ulHcMza5Ian25QVuzYcakbxw2WkX apw
has assertion: bp(GO:"response to hypoxia") -> p(HGNC:RPLP2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.397+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(HGNC:RPLP2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18079489

3
value: Of note, 60S acidic ribosomal protein P2 is increased when the UPR is induced by hypoxia, a condition associated with a global inhibition of protein synthesis (31, 49).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18079489

RAUqQmk61cXC GFzUx0bM7UQ6yWHG93lYWRI6azCwBhZA
has assertion: p(HGNC:S100A9) -> kin(p(PFH:"MAPK Erk1/3 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.399+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:S100A9) -> kin(p(PFH:"MAPK Erk1/3 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18079489

5
value: S100-A9 binds the transcription factors NF-kB and P53, and activates the P38 and ERK MAPK kinases and the receptor for advanced glycated end products (RAGE) (50).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18079489

RAfSvd0qPWnoWSYecVe0bgkvQCaI5skOQ-joEpwh3n8Zo
has assertion: p(HGNC:S100A9) -> kin(p(HGNC:MAPK14))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.401+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:S100A9) -> kin(p(HGNC:MAPK14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18079489

5
value: S100-A9 binds the transcription factors NF-kB and P53, and activates the P38 and ERK MAPK kinases and the receptor for advanced glycated end products (RAGE) (50).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18079489

RATsnwQbQ8nrSsrlwCpptFpRI9X-snNTA8jchojjq-ZM8
has assertion: a(SCHEM:Calcium) -> bp(GO:"response to unfolded protein")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.404+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> bp(GO:"response to unfolded protein")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18079489

2
value: The UPR is activated in response to cellular stressors such as RONS, increases in cytosolic calcium, and hypoxia, which impair protein folding in the lumen of the endoplasmic reticulum (ER) (18, 19, 22)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18079489

RAQC1qcvZO ticT3wUGPpYVWoVVgPiYw0V-GVVA7clSW8
has assertion: p(HGNC:CLU) -> p(HGNC:SMAD2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.409+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CLU) -> p(HGNC:SMAD2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18082619

4
value: These findings suggest that CLU regulates TGF-beta signaling pathway by modulating the stability of Smad2/3 proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18082619

RAdVJGS-Xpg1-LWruhurpmY49 q76lKqQslxeB3-diBx8
has assertion: complex(p(HGNC:CREB1,pmod(P,S,133)),g(HGNC:BCL2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.413+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:CREB1,pmod(P,S,133)),g(HGNC:BCL2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18086876

3
value: At the nuclear level, phospho-CREB and TORC2 were demonstrated to bind to CRE-I of the Bcl-2 promoter, and GIP treatment resulted in increases in their interaction.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18086876

RAVUhbBB-mTv3Qza34xM2N9tXYuuab4uOdXnaDsPjQ1Kc
has assertion: p(HGNC:HES6) -| bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.426+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:HES6) -| bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18160400

3
value: Hes6 inhibits cell proliferation through induction of p21 cyclin-dependent kinase inhibitor.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18160400

RAVDYYQGiDvQ6BW0p8NRfSkoEO680BIr3v2q3OpT vidY
has assertion: p(HGNC:PRKCA) -> bp(GO:"cell cycle arrest")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.427+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PRKCA) -> bp(GO:"cell cycle arrest")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18162471

3
value: Analysis of cell cycle distribution revealed that PKCalpha-depletion impaired PMA-induced G2/M arrest in H358 cells (Fig. 6A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18162471

RAZbXmaDQmg0OSDiCfSyAcb5alJuaTjDkCp-g894fZ6nM
has assertion: a(CHEBI:"arachidonic acid") => p(HGNC:ALOX5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.452+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"arachidonic acid") => p(HGNC:ALOX5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18172772

3
value: See Figure 1: Alternatively, arachidonic acid is also a substrate for lipoxygenases (ALOX-5, 12, and 15), which catalyze the synthesis of proinflammatory leukotrienes and lipoxins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18172772

RASvNoLpmcBP9YnOrMHFL5SXnpC5-GDVuVNm14V62342I
has assertion: a(CHEBI:rosiglitazone) -> sec(p(EGID:3630))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.465+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:rosiglitazone) -> sec(p(EGID:3630))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18191635

4
value: In the present study, we examined the effects of rosiglitazone (RGZ) (rosaglitazone is a Pparg agonist) on insulin release and synthesis in pancreatic beta-cell (INS-1). Insulin release and synthesis were stimulated by treatment with RGZ for 24h. RGZ upregulated the expressions of GLUT-2 and glucokinase (GCK). Moreover, it was found that RGZ increased the expression of BETA2/NeuroD gene which could regulate insulin gene expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18191635

RAR7fjAvdoEDEp7e9vJJVUolHutuNxe2hYxHHM41 eSfQ
has assertion: cat(p(HGNC:TLR3)) -> tscript(p(HGNC:IRF3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.491+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:TLR3)) -> tscript(p(HGNC:IRF3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18202435

6
value: Double-stranded RNA is a marker for viral infection that is recognized by TLR3. TLR3 triggering activates specific signaling pathways that culminate in the activation of NF-kappaB and IRF3 transcription factors, as well as apoptosis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18202435

RAQAvgO2qDXAxToHNiKPjT0rhuj-XDl03w1JiHbCWPo1g
has assertion: kin(p(HGNC:MAPK1)) => p(HGNC:FOXO3,pmod(P,S,344))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.494+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) => p(HGNC:FOXO3,pmod(P,S,344))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18204439

5
value: Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by directly interacting with and phosphorylating FOXO3a at Ser 294, Ser 344 and Ser 425, which consequently promotes cell proliferation and tumorigenesis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18204439

RATr2ThlnCa4Mv2vAJoRrzhI6JXWDx7uudtIeuX8iB0mk
has assertion: kin(p(HGNC:ATM)) -| complex(p(HGNC:MDM2),p(HGNC:TP53))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.498+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:ATM)) -| complex(p(HGNC:MDM2),p(HGNC:TP53))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18208352

7
value: ATM-mediated phosphorylation of p53 stabilizes this tumor suppressor protein by reducing constitutive interactions with MDM2, which usually promotes the degradation of p53 (Figure 1) (Giaccia and Kastan, 1998; Chin et al., 1999).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18208352

RAaTETDYgdbl3Td9j8jKGzoidxWHtx5rhRI2o-vxPXf9U
has assertion: a(CHEBI:"reactive oxygen species") -> kin(p(HGNC:MAPK8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.504+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -> kin(p(HGNC:MAPK8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18208352

4
value: TPA stimulates increased generation of ROS and initiates the stress-activated protein kinase (SAPK) pathway via protein kinase C (PKC) bII activation (Datta et al., 2000), representing typical characteristics of STASIS...Activation of stress kinases (JNK, MAPK, p38) (Day 2008; Gao et al., 2008; Kirkham and Rahman, 2006; Kliment et al., 2008; Koli et al., 2008)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18208352

RAWPFn BRFi87mcrIjlzjGT4peFroIoR05rv0yClme-6w
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> kin(p(HGNC:MAPK8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.507+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> kin(p(HGNC:MAPK8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18208352

4
value: TPA stimulates increased generation of ROS and initiates the stress-activated protein kinase (SAPK) pathway via protein kinase C (PKC) bII activation (Datta et al., 2000), representing typical characteristics of STASIS...Activation of stress kinases (JNK, MAPK, p38) (Day 2008; Gao et al., 2008; Kirkham and Rahman, 2006; Kliment et al., 2008; Koli et al., 2008)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18208352

RAd55VMj5IA1PlB25MomaFghNIfB0pho5e0bh0Vg47nQ8
has assertion: tscript(p(HGNC:"NKX2-1")) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.561+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:"NKX2-1")) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18212743

4
value: Small interfering RNA (siRNA)-mediated knockdown of TITF1 in lung cancer cell lines with amplification led to reduced cell proliferation, manifested by both decreased cell-cycle progression and increased apoptosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18212743

RATvdfD3g0tv 55sOSJnarM-lr-oDNnFHoNqpgOK-8nyw
has assertion: a(CHEBI:lipopolysaccharide) -> p(MGI:Pak2,pmod(P,S,141))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.574+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> p(MGI:Pak2,pmod(P,S,141))
label: p(MGI:Cdkn1a) -> (a(CHEBI:lipopolysaccharide) -> p(MGI:Pak2,pmod(P,S,141)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18239191

5
value: MPO Activity and Phosphorylation of p21-Activated Kinase on ser141 Residue Were Decreased in Lungs of p212/2 Mice in Response to CS Exposure or LPS Aerosolization
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18239191

RAco0lSKAVwwTC1YnydxUD672TluNU5ez2L8GhrkeKBrA
has assertion: a(CHEBI:lipopolysaccharide) -> tscript(complex(NCM:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.579+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> tscript(complex(NCM:"Nfkb Complex"))
label: p(MGI:Cdkn1a) -> (a(CHEBI:lipopolysaccharide) -> tscript(complex(NCM:"Nfkb Complex")))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18239191

5
value: Moreover, genetic knockout of p21 attenuated angiotensin II?induced NF-kB activation by decreasing the production of reactive oxygen species (ROS) in vitro and in vivo (25). Targeted disruption of p21 was associated with decreased NF-kB activation in glial cells in response to lipopolysaccharide (LPS) (27).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18239191

RAaiVppOTo6QseAQXE4cB54TOQuQy2Gl -5HUnUaqbPcE
has assertion: a(CHEBI:lipopolysaccharide) -> p(MGI:Il1b)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.582+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> p(MGI:Il1b)
label: p(MGI:Cdkn1a) -> (a(CHEBI:lipopolysaccharide) -> p(MGI:Il1b))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18239191

5
value: Our data showed that CS exposure increased the levels of KC, MCP-1, IL-6, and TNF-a in the lungs and that these levels were significantly decreased in p21-/- mice (Figure 6A). The levels of KC, MCP-1, IL-6 and IL-1b were also significantly reduced in the lungs of p21-/- mice compared with WT mice exposed to aerosolized LPS (Figure 6B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18239191

RAcSqs7Zbb-aBpxILEVVhy2k3L3icFWOUE91GQBQHJ5QI
has assertion: a(CHEBI:lipopolysaccharide) -> p(MGI:Il6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.589+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> p(MGI:Il6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18239191

3
value: Our data showed that CS exposure increased the levels of KC, MCP-1, IL-6, and TNF-a in the lungs and that these levels were significantly decreased in p21-/- mice (Figure 6A). The levels of KC, MCP-1, IL-6 and IL-1b were also significantly reduced in the lungs of p21-/- mice compared with WT mice exposed to aerosolized LPS (Figure 6B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18239191

RAdP47yTSRXkQxEena0qRhbBY7NHHUR0onRP4wneCukO4
has assertion: a(CHEBI:lipopolysaccharide) -> p(MGI:Tnf)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.590+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> p(MGI:Tnf)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18239191

3
value: Our data showed that CS exposure increased the levels of KC, MCP-1, IL-6, and TNF-a in the lungs and that these levels were significantly decreased in p21-/- mice (Figure 6A). The levels of KC, MCP-1, IL-6 and IL-1b were also significantly reduced in the lungs of p21-/- mice compared with WT mice exposed to aerosolized LPS (Figure 6B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18239191

RAa1qj0nozmi4YIqotihiK6FHmLuXLbWbDFvWzMRP7EPI
has assertion: kin(p(PFM:"Mapk p38 Family")) -> r(MGI:Ptgs2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.591+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFM:"Mapk p38 Family")) -> r(MGI:Ptgs2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18241616

5
value: Kumagai et al. [40] examined the relation between COX-2 mRNA stability and HNE-activated p38 MAPK pathway and found that the p38 MAPK–specific inhibitor accelerated COX-2 mRNA degradation [15••,43].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18241616

RAQPclXyQVUY8sMc9A4AcGdM1YoEX- AJzkU2trojy5 c
has assertion: cat(p(HGNC:EP300)) => tscript(p(HGNC:TP53))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.593+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:EP300)) => tscript(p(HGNC:TP53))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18243116

6
value: We demonstrate that Skp2 forms a complex with p300 through the CH1 and the CH3 domains of p300 to which p53 is thought to bind and antagonizes the interaction between p300 and p53 in cells and in vitro. As Skp2 antagonizes the interaction between p300 and p53, Skp2 suppresses p300-mediated acetylation of p53 and the transactivation ability of p53.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18243116

RAZjpZspDXs xgMcCEhcWzr7 bb0eEa6z5SndyvnUsDcs
has assertion: kin(p(HGNC:PRKCZ)) -> p(HGNC:SP1,pmod(P,S,670))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.617+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PRKCZ)) -> p(HGNC:SP1,pmod(P,S,670))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18258854

5
value: Here we have used a variety of approaches to identify 3 amino acids (Thr668, Ser670, and Thr681) in the zinc finger domain of Sp1 that are modified by PKC-zeta
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18258854

RAcNnx2OX1x0eNGnle upH2A-tw-CaXj5flw Fc82LJ0
has assertion: kin(p(HGNC:PRKCZ)) -> p(HGNC:SP1,pmod(P,T,681))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.620+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PRKCZ)) -> p(HGNC:SP1,pmod(P,T,681))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18258854

5
value: Here we have used a variety of approaches to identify 3 amino acids (Thr668, Ser670, and Thr681) in the zinc finger domain of Sp1 that are modified by PKC-zeta
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18258854

RAZ4OFG6MNafanR4ktwLXFA7RrOVjTIgv8C3pqK-QQLAM
has assertion: p(MGI:Dsg3) -| bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.642+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Dsg3) -| bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18268536

3
value: Anti-Dsg3 adhesion-disrupting antibodies are produced in the majority of Pemphigus vulgaris patients (Amagai et al., 1991; Payne et al., 2004) or experimentally in the mouse (monoclonal anti-Dsg3 (AK23)) (Tsunoda et al., 2003). When added to cultured mouse keratinocytes at the beginning of the transitional phase, they induce, besides other events (for review see Amagai et al., 2006), sustained proliferation, in correlation with a dramatic upregulation of c-Myc (Williamson et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18268536

RAaiO3mfYcP1kj1AJn3XNKh3EFcbimtm0PEs6eoQsY-tg
has assertion: path(SDIS:"integrin mediated cell adhesion") -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.643+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"integrin mediated cell adhesion") -> bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18268536

2
value: Blocking phosphatidylinositol trisphosphate kinase (PI3K) or alternatively, EGF-R of suspension cells, induces apoptosis. Inversely, if integrins are cross-linked, proliferation is maintained (Adams and Watt, 1989; Watt et al., 1993; Rodeck et al., 1997; Nikolopoulos et al., 2005).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18268536

RAV sh 7LTw0 UEKiqO8YxNSNRJQNpb2FsWxXRxNHjAjA
has assertion: kin(complex(NCM:"p85/p110 PI3Kinase Complex")) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.646+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCM:"p85/p110 PI3Kinase Complex")) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18268536

3
value: Blocking phosphatidylinositol trisphosphate kinase (PI3K) or alternatively, EGF-R of suspension cells, induces apoptosis. Inversely, if integrins are cross-linked, proliferation is maintained (Adams and Watt, 1989; Watt et al., 1993; Rodeck et al., 1997; Nikolopoulos et al., 2005).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18268536

RAWtg4a78Cmxu2jQppGD0AhHcuQ78h2cRQPfAhgGeJf6M
has assertion: p(MGI:Abcb1a) -| r(MGI:Mmp3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.659+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Abcb1a) -| r(MGI:Mmp3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18275070

4
value: See Table 2: Inflammatory Gene Expression in 12-16 Week Mdr1a(-/-) Colon Compared to Age-matched Controls. p< 0.05
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18275070

RAea80Py7YOPy3dgezLg4PIb4NVu-DSc2wAQw2tez7j c
has assertion: p(MGI:Abcb1a) -> r(MGI:Mal)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.667+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Abcb1a) -> r(MGI:Mal)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18275070

4
value: See Table 3: Significant differences in colonic mucosal gene expression in 4-5 week mdr1a (-/-) mice versus age-matched FVB controls. Note: p<0.05 and all fold changes are greater than or less than 2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18275070

RAd-JmkvOPBW7nWtTGJvkbdNYk7lImCMlTZq63xMr-Ckc
has assertion: p(MGI:Abcb1a) -> r(MGI:Reg3g)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.668+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Abcb1a) -> r(MGI:Reg3g)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18275070

4
value: See Table 3: Significant differences in colonic mucosal gene expression in 4-5 week mdr1a (-/-) mice versus age-matched FVB controls. Note: p<0.05 and all fold changes are greater than or less than 2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18275070

RAdM2BvDytbnEtkdvKKdvvA-wyMK0l9n89yHc5l1QyT5w
has assertion: p(MGI:Abcb1a) -| r(MGI:"H2-DMb2")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.677+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Abcb1a) -| r(MGI:"H2-DMb2")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18275070

4
value: See Table 3: Significant differences in colonic mucosal gene expression in 4-5 week mdr1a (-/-) mice versus age-matched FVB controls. Note: p<0.05 and all fold changes are greater than or less than 2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18275070

RAX16DaBBMPejqsiQ5mvGnf4rFu0JWtbDYPUhbDJGwdac
has assertion: p(MGI:Abcb1a) -| r(MGI:Psmb8)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.689+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Abcb1a) -| r(MGI:Psmb8)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18275070

4
value: See Table 3: Significant differences in colonic mucosal gene expression in 4-5 week mdr1a (-/-) mice versus age-matched FVB controls. Note: p<0.05 and all fold changes are greater than or less than 2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18275070

RAbUdoyYmyiWWjaEPKiiQG26A5YKOf3V7QphWbn1PfgWg
has assertion: p(MGI:Abcb1a) -| r(MGI:Psmb9)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.690+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Abcb1a) -| r(MGI:Psmb9)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18275070

4
value: See Table 3: Significant differences in colonic mucosal gene expression in 4-5 week mdr1a (-/-) mice versus age-matched FVB controls. Note: p<0.05 and all fold changes are greater than or less than 2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18275070

RAWusFGkffHXpRCrc6dueMM3D1 BlpGu3-v9v9GM8-Anw
has assertion: p(MGI:Abcb1a) -| r(MGI:Ubd)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.694+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Abcb1a) -| r(MGI:Ubd)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18275070

4
value: See Table 3: Significant differences in colonic mucosal gene expression in 4-5 week mdr1a (-/-) mice versus age-matched FVB controls. Note: p<0.05 and all fold changes are greater than or less than 2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18275070

RAUfcg-2GpdG2uhUs0tOyAfdYcJL4Aq3x0GBiiI5 XnLk
has assertion: a(CHEBI:cholesterol) -> p(MGI:Abcg1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.697+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:cholesterol) -> p(MGI:Abcg1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18276911

3
value: After initial cholesterol loading, mouse SMCs upregulate ABCA1 and ABCG1 while downregulating the typical smooth muscle markers including smooth muscle ?-actin, ?-tropomyosin and myosin heavy chain 32.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18276911

RASraibmCmekRQaVt7Uk nQARmFS3xQtkb2sS8O hPv o
has assertion: tscript(p(HGNC:PPARG)) -| tscript(complex(NCH:"AP-1 Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.702+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:PPARG)) -| tscript(complex(NCH:"AP-1 Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18276926

5
value: PPAR-{gamma} inhibits the activities of NF-{kappa}B and AP-1 to suppress the promoter activity of these molecules
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18276926

RAeC2AbbyspOtqPuUMxq9W88Y4N0Y2732Jcy5JeHyOG04
has assertion: p(HGNC:ATM) -> kin(p(HGNC:ATR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.709+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ATM) -> kin(p(HGNC:ATR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18285803

5
value: ATR activation by DSBs requires ATM and MRN–CtIP, it occurs only during S and G2 phases, and it is abolished by CDK inhibition13,44
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18285803

RAfdsqtusBHIZi gH8z-5py4rpzTJhufmXEb1n8ys4RZk
has assertion: complex(p(HGNC:RNF8),p(HGNC:MDC1)) -> p(HGNC:BRCA1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.714+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:RNF8),p(HGNC:MDC1)) -> p(HGNC:BRCA1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18285803

6
value: Recent evidence suggests that RNF8 binds to MDC1 and ubiquitylates phosphorylated H2AX. These events facilitate the recruitment of factors (such as BRCA1 and 53BP1) that are required for DNA repair and checkpoint signalling, probably through a ubiquitin-ligase cascade98?100,102 (FIG. 2). (primary sources used as in statements)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18285803

RAV3YQoL-6y7tOdkUN-B301 Wx0quH8SE8syNedxxxHRM
has assertion: p(MGI:Trim24) -| path(SDIS:calcification)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.716+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Trim24) -| path(SDIS:calcification)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18287084

3
value: Calcifications in lungs and vibrissae affected 100% and 88% of the 8- to 10-month-old TIF1/ mutants, respectively.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18287084

RAc1i9FpNsz8RpYNN Hv-GyLKR-MAiYM3fXra97sp7yQg
has assertion: tscript(p(MGI:Nr1h3)) -> bp(GO:"cholesterol transport")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.720+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Nr1h3)) -> bp(GO:"cholesterol transport")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18292555

4
value: Liver X receptor (LXR) alpha and beta are members of the nuclear receptor superfamily of ligand-activated transcription factors. Best known for triggering \"reverse cholesterol transport\" gene programs upon their activation by endogenous oxysterols, LXRs have recently also been implicated in regulation of innate immunity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18292555

RAURxfqc88OKTXs0KQ5ZIfaIK 138vJlSZhm4nrZDeVsg
has assertion: m(MGI:Mir155) -| r(MGI:Arntl)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.724+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir155) -| r(MGI:Arntl)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18299402

4
value: Figure 6 A. Repression of specific target genes involved in myeloid hyperplasia and/or hematopoiesis by miR-155.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18299402

RAb gbCcyG3o3yyC HCU2GcvUdvv3JbJQeTRS zxeolsM
has assertion: m(MGI:Mir155) -| r(MGI:Cux1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.728+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir155) -| r(MGI:Cux1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18299402

4
value: Figure 6 A. Repression of specific target genes involved in myeloid hyperplasia and/or hematopoiesis by miR-155.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18299402

RAarkPbrjA9WUO-g-o sef2gJ3UiWSlavx4mc9sliresw
has assertion: m(MGI:Mir155) -| r(MGI:Sla)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.734+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir155) -| r(MGI:Sla)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18299402

4
value: Figure 6 A. Repression of specific target genes involved in myeloid hyperplasia and/or hematopoiesis by miR-155.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18299402

RASFn9DJ64bj0B1 V7fcz5GJZL4xWAeSDU-BG YQXeELo
has assertion: p(HGNC:CXCL1) -> bp(GO:"neutrophil chemotaxis")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.742+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CXCL1) -> bp(GO:"neutrophil chemotaxis")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18311596

3
value: Here we demonstrate that cholesterol was absolutely required for polarized redistribution of key chemotactic mediators in human neutrophils in response to all chemoattractants tested (fMet-Leu-Phe, and the chemokines CXCL1, CXCL8 and CXCL12).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18311596

RAQUFF4nqw-mF6vfmDQVFDo6JgxnL--e7N5ZXkdp57L98
has assertion: p(MGI:Cav1) -> (path(MESHD:Hyperoxia) -> bp(GO:"cell death"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.746+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Cav1) -> (path(MESHD:Hyperoxia) -> bp(GO:"cell death"))
label: path(MESHD:Hyperoxia) -> bp(GO:"cell death")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18323531

4
value: After 72 hours of hyperoxia exposure, we found that cav-1-/- fibroblasts were resistant to hyperoxia-induced cell death, with 60% survival observed in cav-1-/- fibroblasts compared with less than 20% survival in the wild-type fibroblasts (Figure 1A)....Similar results were observed in MLEC cells (Figure 1B). Approximately 50% survival after hyperoxia in cav-1-/- MLEC was found, compared with 20% survival in wild-type MLEC - mouse lung endothelial cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18323531

RAexgpEMM2SaQRecESQnnX0TP HuEmDDeOMsWzOGTRmQ0
has assertion: p(EGID:183) -> r(HGNC:FN1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.750+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:183) -> r(HGNC:FN1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18337545

4
value: By utilizing short interfering RNAs against ETS-1, we have also determined that ETS-1 is required to induce the production of fibronectin in response to ANG II.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18337545

RAb4yQ2MnMk bVEr1in61vnAjEzrA94rzV2GB8YyDADgY
has assertion: tscript(p(MGI:Pitx2)) => r(MGI:Fshb)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.754+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Pitx2)) => r(MGI:Fshb)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18339718

5
value: Here, we examined mechanisms through which the family of PITX proteins control murine FSH beta-subunit (Fshb) transcription. We observed that endogenous PITX1 and PITX2 isoforms from murine LbetaT2 gonadotrope cells could bind a highly conserved proximal cis-element. Transfection of PITX1 or PITX2C in heterologous cells stimulated both murine and human Fshb/FSHB promoter-reporter activities, and in both cases, mutation of the critical cis-element abrogated these effects.In homologous LbetaT2 cells, the same mutation decreased basal reporter activity and greatly reduced activin A-stimulated transcription from murine and human promoter-reporters. Transfecting dominant-negative forms of PITX1 or PITX2C or knocking down PITX1 or -2 expression by RNA interference in LbetaT2 cells inhibited murine Fshb transcription, confirming roles for endogenous PITX proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18339718

RATL6uOL-mSBpR430xjcOKuSzCf6GsCo550GGjGCiH4OI
has assertion: tscript(p(MGI:Hoxc6)) => r(MGI:Cntn1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.759+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Hoxc6)) => r(MGI:Cntn1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18339881

5
value: See Table 2. HOXC6 direct targets affected by loss of HOXC6 expression in normal mouse prostates. All fold changes are greater than or equal to 1.5
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18339881

RAWOjI Fs-UHLFhscALJ6FM7g1sQHPUcJCfB25TrZeg4s
has assertion: tscript(p(MGI:Hoxc6)) => r(MGI:Errfi1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.762+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Hoxc6)) => r(MGI:Errfi1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18339881

5
value: See Table 2. HOXC6 direct targets affected by loss of HOXC6 expression in normal mouse prostates. All fold changes are greater than or equal to 1.5
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18339881

RAZp0NL1vslVQW15JqyorXHDnFDYFGaIPcX968gsM8E8s
has assertion: tscript(p(HGNC:HOXC6)) => r(HGNC:FAM101A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.764+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:HOXC6)) => r(HGNC:FAM101A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18339881

5
value: See Table 2. HOXC6 direct targets affected by loss of HOXC6 expression in normal mouse prostates. All fold changes are greater than or equal to 1.5
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18339881

RAfrN4NmEXaLWKg3Bi2sEmh 6rf-nWx7jZn-a-MzCP46w
has assertion: tscript(p(MGI:Hoxc6)) => r(MGI:Tnfaip8)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.778+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Hoxc6)) => r(MGI:Tnfaip8)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18339881

5
value: See Table 2. HOXC6 direct targets affected by loss of HOXC6 expression in normal mouse prostates. All fold changes are greater than or equal to 1.5
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18339881

RAWBaQt6ufRyiQOtc2A1Uk8LwvwE1PbTHwANmwdYrnI1U
has assertion: tscript(p(HGNC:HOXC6)) => r(HGNC:ZNF536)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.781+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:HOXC6)) => r(HGNC:ZNF536)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18339881

5
value: See Table 2. HOXC6 direct targets affected by loss of HOXC6 expression in normal mouse prostates. All fold changes are greater than or equal to 1.5
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18339881

RAb NM-Z0H7KTRlX vGB2uj5aIXatrLAMQv2z pwzwMNM
has assertion: p(HGNC:MDM2) -> p(HGNC:MDM2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.785+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MDM2) -> p(HGNC:MDM2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18340116

4
value: MI-43 induced the accumulation of p53 and its downstream target genes, Mdm2, p21, Noxa and Puma only in wt p53-containing cells, indicating that disruption of Mdm2-p53 binding increases p53
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18340116

RAShka1qp 0nn7UuIK83nzMG-ZqgiC27IP3Ug6ter zzg
has assertion: p(HGNC:BHLHE41) -| r(HGNC:DBP)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.788+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:BHLHE41) -| r(HGNC:DBP)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18342625

4
value: Consistently, cotransfection assays demonstrate that STRA13 and DEC2 both antagonize CLOCK:BMAL1 dependent transactivation of the Rev-erbalpha {NR1D1} and Dbp promoters.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18342625

RAYsT5fGxhaNpqX1oUPC4DZoN1QKCO7dYS47OBlLKoXDQ
has assertion: tscript(p(HGNC:BHLHE41)) -| r(HGNC:NR1D1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.792+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:BHLHE41)) -| r(HGNC:NR1D1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18342625

5
value: Consistently, cotransfection assays demonstrate that STRA13 and DEC2 both antagonize CLOCK:BMAL1 dependent transactivation of the Rev-erbalpha {NR1D1} and Dbp promoters.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18342625

RAaKBH6sEKPMJpCjfVYEU0LVBFq0472EAQzYG4ios142M
has assertion: kin(p(PFH:"AKT Family")) => p(HGNC:BAD,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.794+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"AKT Family")) => p(HGNC:BAD,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18344980

5
value: Although AKT can phosphorylate several proteins4, we focused on BAD, FOXO, IKKa, TSC2 and eNOS, as the consequence of AKT phosphorylation of these proteins is not redundant with the functions of the oncoproteins expressed in cells used in the cellmixing assay of tumour maintenance5 (Supplementary Fig. 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18344980

RAXPNANyJYmSAxZpj-K3cJC7REI4vK6kNg69Ixb2XyFhs
has assertion: kin(p(PFH:"AKT Family")) => p(HGNC:NOS3,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.796+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"AKT Family")) => p(HGNC:NOS3,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18344980

5
value: Although AKT can phosphorylate several proteins4, we focused on BAD, FOXO, IKKa, TSC2 and eNOS, as the consequence of AKT phosphorylation of these proteins is not redundant with the functions of the oncoproteins expressed in cells used in the cellmixing assay of tumour maintenance5 (Supplementary Fig. 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18344980

RAemdFfaKBRTOBh3959cHRic2-iiYmaevBI-hzJ8gweHo
has assertion: p(HGNC:CTNNB1) -> (p(HGNC:TGFB1) -> p(HGNC:ACTA2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.806+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CTNNB1) -> (p(HGNC:TGFB1) -> p(HGNC:ACTA2))
label: p(HGNC:TGFB1) -> p(HGNC:ACTA2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18346908

6
value: Accordingly, silencing of ?-catenin (Fig. 4A and D) by siRNA (100 nM), did not affect basal levels of ?-SMA, but reduced TGF-?1-induced ?-SMA expression (Fig. 4C and E).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18346908

RAagsY y MDuB22-8xpWqcNMucKHIQm1z9YwsZnBEq a4
has assertion: p(HGNC:TGFB1) -> kin(p(HGNC:MAPK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.807+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TGFB1) -> kin(p(HGNC:MAPK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18346908

5
value: TGF-beta1 treatment activated the MAPK pathway, as shown by an increased phosphorylation of extracellular-regulated kinases (ERK)1/2 after 30 min of exposure.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18346908

RAVEUVrlao3htg0eKfOs5Reh HINoJXCAYcUCCSJSyULU
has assertion: p(HGNC:TGFB1) -> kin(p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.809+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TGFB1) -> kin(p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18346908

5
value: TGF-beta1 treatment activated the MAPK pathway, as shown by an increased phosphorylation of extracellular-regulated kinases (ERK)1/2 after 30 min of exposure.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18346908

RAWECXpXd5o-aaTxfVey0UAhMjcdcSG3u2LeAQB1qsqeU
has assertion: a(CHEBI:"reactive oxygen species") -| kin(p(HGNC:IKBKB))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.821+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -| kin(p(HGNC:IKBKB))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18355884

4
value: In addition, IKK? and IKK? contain a redox sensitive cysteine residue that is sensitive to oxidative modification. Oxidative modification of this residue by ROS results in inactivation of IKK (Rossi et al., 2000; Kapahi et al., 2000)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18355884

RAV LUB5cTdx-FkG83Q5ZOGRyYO4q4xRFtsvDlGQls2Lo
has assertion: tscript(complex(NCH:"Nfkb Complex")) => r(HGNC:MYLK)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.832+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"Nfkb Complex")) => r(HGNC:MYLK)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18363837

4
value: TNF-alpha-induced increase in MLCK promoter activity was mediated by NF-kappaB activation. There were eight kappaB binding sites on MLCK promoter. The NF-kappaB1 site at +48 to +57 mediated TNF-alpha-induced increase in MLCK promoter activity. The NF-kappaB2 site at -325 to -316 had a repressive role on promoter activity. The opposite effects on promoter activity were due to differences in the NF-kappaB dimer type binding to the kappaB sites. p50/p65 dimer preferentially binds to the NF-kappaB1 site and up-regulates promoter activity; while p50/p50 dimer preferentially binds to the NF-kappaB2 site and down-regulates promoter activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18363837

RAc7G5Zr ixnohewHEIFijPGmbSRaNfSk6BZXUqtzNfxs
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Alcam)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.838+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Alcam)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAW5ZH0 8kKL8SZMCoh-YQM0zGInabrhs5hSySKFMAjX8
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Ctnna1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.848+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Ctnna1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RATerxtMCY2R3olUKwmmbblAT h8Dk117aoQpSMoCNeCI
has assertion: tscript(p(MGI:Meis1)) -| r(EGID:12549)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.850+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(EGID:12549)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAYoZdPNokz2XKNyp3JGv1YgfVCCyaJ7 rlwWA-n4T4 8
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Gm2a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.862+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Gm2a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAYp1bKue8AuGRylnuPKFwSxWyFaW05Z2oEofV-QxnyxQ
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:"H2-DMb2")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.867+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:"H2-DMb2")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAXw8jvoKXEpT vafUIpCbuovYvwZrmMDApCMFrbrvylY
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Hk3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.868+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Hk3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAVbxIkHKlkgVrzCGHl8cebluXt0FSYt6VvLsojVd2MJE
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Hsd11b1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.869+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Hsd11b1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAbG-Uhy87iEbbqQjWMwI6Mh3JfRw0XHvLLNV6uoE6GXM
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Igsf6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.871+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Igsf6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAaqP2WiojmAAyPe5f05CtxwWkbnS5icgHSXUdrgQ8PIA
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Mmp19)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.883+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Mmp19)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAXWoRVS8recEcXqZKC-TD5beWVWp6TZT0TfWfYLSoDjc
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Napsa)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.886+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Napsa)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAdeOMr9AWqnN8wzDuBPkTR0v4iKj DoU--YVoBWsYH48
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Ppm1h)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.893+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Ppm1h)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAQMVkXDAuyE8bwgY0ncC BJAVuXHDe8-x9pGUj7cNsw0
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Pstpip2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.896+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Pstpip2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RATDAENpyWWilCG0LQ8a2kGZI8sx0H-78tTcfanKmNIyU
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Stom)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.905+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Stom)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAYtSYbprsB3BmwQti-qnmox3-SNMKnwSQk1 saVGtwJU
has assertion: tscript(p(MGI:Meis1)) -| r(MGI:Thbs1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.909+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -| r(MGI:Thbs1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAX4Yza--vEaGs7DzApiGLqb 361YC0eRCbsXXMl7GILI
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Abcb1a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.918+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Abcb1a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAQmEpEQ5tBiNCBSrvurxbLhhZO1A3lfkHoZM5EEUfN6g
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Aqp8)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.919+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Aqp8)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RASOaINsELtdi64HF-xN1Z5c0CnyorWKpOSCzB2GOQtG4
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Cnrip1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.928+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Cnrip1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAVl84FWy2KobALu-Df2hLmCSJGvHNQAB KOc70vqPHxU
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Dazl)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.929+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Dazl)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAWSTDIiQJNfFt8h bdVdRAVbuneXR5WuTfcKjoaO6AzY
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Lss)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.958+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Lss)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RARr6uSl4crSnXwIUtXYiNoMlpy9mj8niY5ZMCpdoxdFs
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Neto2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.962+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Neto2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAVPW5PfT-g6BgotzLYWLFOZydvc0Pd0Z2AA0I XNn060
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Sema3a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.982+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Sema3a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAWTLYNdrownQ-X 86xrOut4uFbvhXd VWtdcNUYc7rtQ
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Slc16a12)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.983+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Slc16a12)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAZcpuNFKw7nXajsT3FcjkVJQtiFdozxDfDWw0eq-Irv8
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Slpi)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.986+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Slpi)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAeyJtYj9NhWItfrU87dPvhtZ9-iISUHx7e2HK7 wEHCA
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Stard10)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.990+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Stard10)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAZCD37kvUnvGH9ZxalczTjGHaWmhxEbY8LyDl9kbv5-E
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:"Xlr4e-ps")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.997+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:"Xlr4e-ps")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAYc3BlcwsZE-knQQ1qZidqd0kZbrLIrXGEwQBEpFYEzE
has assertion: tscript(p(MGI:Meis1)) -> r(MGI:Ak1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:52.999+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis1)) -> r(MGI:Ak1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18375036

5
value: Genes were considered to be differentially expressed if they had a difference in expression level between the two conditions that was at least twofold and the extent of difference in expression was statistically significant (p ! 0.05) in a parametric Welsh-analysis of variance t-test. Only genes that showed concordant results in all three replicates were selected for further evaluation. Genes that differed significantly between wild-type Meis1 and the nonleukemogenic Meis1DHD mutant (lacking its DNAbinding domain) were then identified. With this approach 134 genes (70 increased and 64 decreased, Table 1) could be identified as significantly differentially expressed and linked to the oncogenicity of Meis1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18375036

RAUwVOjt9dNGNoiA0P5w9n-lvQc93zNBLvS2INbfHODrk
has assertion: p(HGNC:AKT1,pmod(P,S,473)) => kin(p(HGNC:AKT1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.002+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:AKT1,pmod(P,S,473)) => kin(p(HGNC:AKT1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18381446

5
value: Furthermore, we show that inhibition of mTOR by rapamycin induces the activation of Akt as shown by increased Akt phosphorylation at Ser(473) and the inhibition of 6-TG-induced apoptosis and cell death. Activated Akt is a well-known inhibitor of autophagy.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18381446

RATa2uhnPD09qj-vc-5ap7seFpHLaIKKm-a7Yv8fLOZFQ
has assertion: bp(GO:"response to hypoxia") -> p(EGID:5243)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.005+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(EGID:5243)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18385176

3
value: hypoxia caused HIF-1alpha activation, Pgp overexpression and increased resistance to doxorubicin accumulation and toxicity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18385176

RAS5AS R-YgtVdErdw14Mq6z zMHjDv 2XMDJZnAq3Z58
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:ABCB1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.058+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:ABCB1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18385176

3
value: hypoxia caused HIF-1alpha activation, Pgp overexpression and increased resistance to doxorubicin accumulation and toxicity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18385176

RASmxmUnJGVZ0HSYYkQgzmjYEQubgVPBR sSsA30PV8jQ
has assertion: complex(p(HGNC:IL12A),p(HGNC:IL12B)) -> p(HGNC:STAT3,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.067+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:IL12A),p(HGNC:IL12B)) -> p(HGNC:STAT3,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18389480

6
value: IL-12 and IL-23 tyrosine phosphorylated STAT3 and STAT1, respectively; IL-12, IL-23, and IL-27 tyrosine phosphorylated JAK2 and tyrosine kinase-2; and IL-27 tyrosine phosphorylated JAK1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18389480

RAQY26OM2s2VGCv0gyfIGDR4kph2ltI-YCIk1nzE5JFok
has assertion: complex(p(HGNC:IL12A),p(HGNC:IL12B)) -> p(HGNC:TYK2,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.068+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:IL12A),p(HGNC:IL12B)) -> p(HGNC:TYK2,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18389480

6
value: IL-12 and IL-23 tyrosine phosphorylated STAT3 and STAT1, respectively; IL-12, IL-23, and IL-27 tyrosine phosphorylated JAK2 and tyrosine kinase-2; and IL-27 tyrosine phosphorylated JAK1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18389480

RAZRgXuuc1-ZvwbHeq7CwzPkPTluq6zFQFztXKj-cLLno
has assertion: m(HGNC:MIR29C) -| r(HGNC:COL1A2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.071+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR29C) -| r(HGNC:COL1A2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18390668

4
value: See supplemental Table 4: GAPDH normalized mir-29c candidate target gene expression in HeLa and HepG2 cells. Note: all fold changes are greater than 1.5.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18390668

RAezQcoz7UzH7rJP6Tg 6Oq9eisqJVNN92fhagOrysNxA
has assertion: m(HGNC:MIR29C) -| r(HGNC:LAMC1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.077+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR29C) -| r(HGNC:LAMC1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18390668

4
value: See supplemental Table 4: GAPDH normalized mir-29c candidate target gene expression in HeLa and HepG2 cells. Note: all fold changes are greater than 1.5.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18390668

RAYS3idOp1JOZ70GepOQ1t4WptAF UjaiVel7ctx5Uxy0
has assertion: m(HGNC:MIR29C) -| r(HGNC:TDG)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.078+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR29C) -| r(HGNC:TDG)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18390668

4
value: See supplemental Table 4: GAPDH normalized mir-29c candidate target gene expression in HeLa and HepG2 cells. Note: all fold changes are greater than 1.5.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18390668

RAftTOKCNzd2oH6JJsbTjkHgr mKtTLcsGir1pX1S4k7Q
has assertion: p(HGNC:EZH2) -> bp(GO:"DNA methylation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.087+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EZH2) -> bp(GO:"DNA methylation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18393368

3
value: The knockdown of EZH2 in cultured CC cells decreased p16 INK4a methylation and decreased binding of EZH2 to the p16 INK4a gene promoter. The latter suggested that direct binding of EZH2 is involved in the regulation of the p16 INK4a gene. Our data suggest that over-expression of EZH2 may induce hypermethylation of p16 INK4a promoter followed by decreased expression of p16 INK4a in the multi-step cholangiocarcinogenesis through intraepithelial neoplasm in hepatolithiasis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18393368

RAVpeJPI5-oTI18mbtqpn4w9sARPuv-5-DJMws-6RL-f0
has assertion: p(HGNC:TLR9) -| path(SDIS:"viral infection")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.091+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TLR9) -| path(SDIS:"viral infection")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18398511

3
value: The importance of TLR9 was highlighted by the fact that mice lacking TLR9 showed drastically increased susceptibility to infection with ECTV.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18398511

RAZHKuZTCiC HREKqbfoeanB85he-uU32jDCCRNnf90Qw
has assertion: bp(GO:"hypotonic response") -> tloc(p(HGNC:NFAT5),GOCCACC:"GO:0005634",GOCCACC:"GO:0005737")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.118+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"hypotonic response") -> tloc(p(HGNC:NFAT5),GOCCACC:"GO:0005634",GOCCACC:"GO:0005737")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18411282

4
value: Knockdown of CK11L, a novel isoform of CK1, inhibits hypotonicity-induced OREBP/TonEBP nuclear export.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18411282

RAffAED0TAgG2CBszlrJs8oM3ZIM-I8 gwh0W755BxoPo
has assertion: p(HGNC:NOV) -| bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.138+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NOV) -| bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18418052

3
value: As CCN3 was shown to inhibit cell growth,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18418052

RAV0vhaOL1rKoF1fOCBsxeHQUhwjaHrFpy f3tC1wBFv0
has assertion: p(HGNC:WNT1) -> p(HGNC:ITGB1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.143+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:WNT1) -> p(HGNC:ITGB1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18432252

4
value: It was shown that the frequency of CD29+CD24+ stem cells in the mammary gland increases by a factor of 6.4 following activation of WNT1 (Ref . 201).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18432252

RASEflI28ObFhPSZdZi2fj-buq9GyGx2cklnpWN0EZ4CY
has assertion: tscript(complex(NCH:"Nfkb Complex")) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.150+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"Nfkb Complex")) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18437897

3
value: The Rel/NF-kappaB transcription factors are key regulators of programmed cell death (PCD)... NF-kappaB most commonly antagonizes PCD by activating the expression of antiapoptotic proteins and antioxidant molecules, but it can also promote PCD under certain conditions and in certain cell types
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18437897

RAdoCOnxAnjT-SaTvHtfeKSrT-qUitMFrTEYo8cLgFED0
has assertion: p(RGD:Tgfb1) -> p(RGD:Eln)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.152+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Tgfb1) -> p(RGD:Eln)
label: p(RGD:Tgif1) -| (p(RGD:Tgfb1) -> p(RGD:Eln))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18441095

6
value: As shown in Fig. 4E, the TGF-1-mediated upregulation of tropoelastin expression was inhibited by overexpression of hTGIF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18441095

RAUoWl ZjfEpSSufODYq-l99O3-wC9torKTzM2gJgurXI
has assertion: p(RGD:Tgfb1) -> p(RGD:Eln)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.155+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Tgfb1) -> p(RGD:Eln)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18441095

4
value: In the absence of TGF--neutralizing antibody, tropoelastin protein levels were upregulated by TGF-1 but downregulated by EGF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18441095

RAb5dvuc9wU5JtmvLJmWixqw5EI4J2RRgmm-3H0HZbc6U
has assertion: a(SCHEM:U0126) -| (p(RGD:Egf) -> p(RGD:Tgif1,pmod(P)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.158+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:U0126) -| (p(RGD:Egf) -> p(RGD:Tgif1,pmod(P)))
label: p(RGD:Egf) -> p(RGD:Tgif1,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18441095

5
value: Indeed, AG1478 or U0126 treatment prevented the EGF-mediated increase in phosphorylated and total TGIF levels (Fig. 3B),
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18441095

RAVEd YO9K3 5n5HRlGoJCjl7eYGYPKUzXSz5VN6AZpps
has assertion: p(RGD:Egf) -| (p(RGD:Tgfb1) -> p(RGD:Eln))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.163+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Egf) -| (p(RGD:Tgfb1) -> p(RGD:Eln))
label: p(RGD:Tgfb1) -> p(RGD:Eln)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18441095

6
value: but EGF was still able to downregulate tropoelastin protein levels when the TGF- signaling and tropoelastin expression were rescued by the addition of TGF-1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18441095

RAZ6MaOoZFxVrsPA mIT9w GIDnehsmXLJwa94kS88nGw
has assertion: p(RGD:Tgif1) -| p(RGD:Eln)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.165+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Tgif1) -| p(RGD:Eln)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18441095

4
value: cells that overexpress human TGIF (hTGIF) wild-type (hTGIF WT) or hTGIF mutant (hTGIF 1-148:177- 262), which is devoid of the Smad interaction domain and is not able to interact with Smad2/3 (35). As shown in Fig. 4D, tropoelastin expression was inhibited by overexpression of hTGIF WT in a dose-dependent manner
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18441095

RAU2r3BuTXD XTQVvFdvptEJgnoI2uFNR5uT7SAzgoCd8
has assertion: tscript(p(HGNC:CBFA2T3)) =| r(HGNC:TCF12)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.168+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:CBFA2T3)) =| r(HGNC:TCF12)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18456661

5
value: Our results show that the E-box gene HEB is a direct target of CBFA2T3-ZNF652-mediated transcriptional repression. The CBFA2T3-ZNF652 complex regulates HEB expression by binding to a single ZNF652 response element located within the promoter sequence of HEB. This study also shows that the NHR3 and NHR4 domains of CBFA2T3 interact with a conserved proline-rich region located within the C terminus of ZNF652.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18456661

RAaNSUUIAXfjLfyEB5-mHu3MRvHHx9LLOP r8SVr2YDgY
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> p(HGNC:SGK1,pmod(P,S,422))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.173+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> p(HGNC:SGK1,pmod(P,S,422))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18456663

4
value: Here we report that PI3-K-dependent phosphorylation of SGK-1 requires formation of a complex between SGK-1 and heat-shock protein 90 (Hsp90).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18456663

RAd5QziAly11-2gEC4UxqgbNO U6Twp0rj3GibIQKsULw
has assertion: a(CHEBI:erlotinib) -| path(SDIS:"tumor growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.189+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:erlotinib) -| path(SDIS:"tumor growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18483355

2
value: Epidermal growth factor receptor (EGFR)–specific tyrosine kinase inhibitors (TKI) gefitinib and erlotinib have been developed as therapeutic agents for non–small cell lung cancer (NSCLC) treatment (1, 2, 3).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18483355

RAQ731giWsnc28p9r683gSkBJNYYxcBjIT5JiWa73KPlk
has assertion: kin(p(HGNC:EGFR)) -> kin(p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.195+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:EGFR)) -> kin(p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18483355

6
value: Studies to date suggest that, in these cancers, several (if not all) of the critical downstream signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt, signal transducers and activators of transcription, and extracellular signal-regulated kinase 1 and 2 pathways, are solely controlled by EGFR. Thus, when the tumors are exposed to EGFR inhibitors, these intracellular pathways are turned off and the cancer cells undergo apoptosis (21, 22, 24, 25).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18483355

RAShoBlW50RI8 2fCa9rp6-jzzxfyI5BNsx2GnkyIYw14
has assertion: kin(p(HGNC:EGFR)) -> tscript(p(PFH:"STAT Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.198+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:EGFR)) -> tscript(p(PFH:"STAT Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18483355

6
value: Studies to date suggest that, in these cancers, several (if not all) of the critical downstream signaling pathways, including the phosphoinositide 3-kinase (PI3K)/Akt, signal transducers and activators of transcription, and extracellular signal-regulated kinase 1 and 2 pathways, are solely controlled by EGFR. Thus, when the tumors are exposed to EGFR inhibitors, these intracellular pathways are turned off and the cancer cells undergo apoptosis (21, 22, 24, 25).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18483355

RAdSBsKqSlJ3Y5itDccXFrAY9YnYBFXCu6NMCGFsFBzL4
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Ctsl)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.204+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Ctsl)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1848774

3
value: Primer extension, using RNA from cells transiently transfected with MEP-CAT fusion plasmids, demonstrates that phorbol ester treatment increases the amount of transcript
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1848774

RAXQRT-3IquNnNuHke9fZPZQ8uLotIQ6br9guET1gQKgU
has assertion: p(PFH:"TGFB Family") -| bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.217+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFH:"TGFB Family") -| bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18503568

3
value: AEC actively inhibit the proliferation of both normal and fibrotic fibroblasts via TGF-beta, which induces the prostaglandin E(2) synthesis in fibroblasts
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18503568

RAYVdzoD0aBR3oka-WZ9qcoGsEiqYVMzvnngzb1FCz3K8
has assertion: cat(p(HGNC:NET1)) -> gtp(p(HGNC:RHOA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.221+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:NET1)) -> gtp(p(HGNC:RHOA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18509476

6
value: The regulation of Net1 activity is poorly understood. PAK1-dependent phosphorylation of Net1 on Ser152 and Ser153 inhibits its GEF activity and abolishes Net1-dependent RhoA activation and stress fiber induction [15].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18509476

RAQRYZmaaU6gx6xxCBhddPBqsCg6ON4R FxpzCuVebBJY
has assertion: cat(p(HGNC:PRODH)) -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.222+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:PRODH)) -> a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18509496

4
value: Recent studies have also demonstrated that PPAR? activation induces proline oxidase, which will result in increased production of cytotoxic reactive oxygen species (ROS) [36].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18509496

RAU9viB2-smi79heo2mRlrD6y 1464QTnDXKdYiILCj9E
has assertion: p(HGNC:IL6) -> cat(p(HGNC:CBL))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.235+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL6) -> cat(p(HGNC:CBL))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18519587

5
value: Here we found that IL-6 stimulation induced lysosome-dependent degradation of gp130, which correlated with an increase in the K63-linked polyubiquitination of gp130. The stimulation-dependent ubiquitination of gp130 was mediated by c-Cbl, an E3 ligase, which was recruited to gp130 in a tyrosine-phosphorylated SHP2-dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18519587

RASpADo2K1jjDOGDzFmXFELXK7-mrUbzUb1iN6e4o6SZs
has assertion: p(HGNC:PDGFB) -> bp(GO:angiogenesis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.239+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PDGFB) -> bp(GO:angiogenesis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18524994

3
value: Our cellular and molecular dissection showed that the PDGF-BB/PDGFRbeta kinase axis promoted MM tumor growth and vessel sprouting by activating ERK1/2, AKT, and the transcription of MMEC-released proangiogenic factors, such as vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18524994

RAdD2Jvj7Q3jm2zfBI1nbX4KvzQdxJCTZOTFQ0Pgrok 4
has assertion: p(HGNC:PDGFB) -> kin(p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.242+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PDGFB) -> kin(p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18524994

5
value: Our cellular and molecular dissection showed that the PDGF-BB/PDGFRbeta kinase axis promoted MM tumor growth and vessel sprouting by activating ERK1/2, AKT, and the transcription of MMEC-released proangiogenic factors, such as vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18524994

RAWVHg3Lr52S453IFFndTS2mgCqV60nLfvwxEqP8Zttyg
has assertion: tscript(p(HGNC:NR3C1)) =| tscript(complex(NCH:"AP-1 Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.246+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:NR3C1)) =| tscript(complex(NCH:"AP-1 Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18535250

5
value: Moreover, nTrip6 is an essential component of glucocorticoid receptor (GR)-mediated trans-repression of AP-1, in that it mediates the tethering of GR to the promoter-bound AP-1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18535250

RAfqRrEaL8Bw8XlSVH6TB-gcPUtvvd6cMmZC1knlsZ-G0
has assertion: p(MGI:Adipoq) -> kin(p(MGI:Map2k2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.254+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Adipoq) -> kin(p(MGI:Map2k2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18555587

5
value: gAd induced the phosphorylation of MEK1/2 and ERK1/2 in RAW264 cells. In addition, the gAd-induced phosphorylation of MEK1/2 and ERK1/2 was dramatically reduced by PD98059 and U0126, respectively.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18555587

RAdU0p5fUybXxwkGpQc 4fugp1KPdvxGO1fahY6bbmqXo
has assertion: kin(p(HGNC:MAP2K1)) -> tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.255+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAP2K1)) -> tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18555777

5
value: Besides NF-kB, the activation of C/EBPb also increased in response to MEK induction and the C/EBPb messenger RNA itself was also upregulated during OIS (Figure S9).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18555777

RAXLwgqF6IgBu Ka9VBnOrpNL1VyT-cxZTAY0-TCxv4Js
has assertion: cat(p(EGID:3579)) -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.257+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(EGID:3579)) -> a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18555777

4
value: The location of CXCR2 in endosomes can be considered as a surrogate marker for CXCR2 activation (Sai et al., 2006 and Figure S12) and correlates with other effects caused by CXCR2 activation such as production of reactive oxygen species (ROS) (Figure S13).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18555777

RARrZoErtWT1iA7WenGMTA 4BoAHCUsP8ygmsx77d0FRg
has assertion: a(CHEBI:aldosterone) -| r(HGNC:ASB4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.262+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:aldosterone) -| r(HGNC:ASB4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18555797

3
value: Transactivated genes in HBMEC exposed to aldosterone (107 M) for 6 h by gene array
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18555797

RAbLOto 0OJjStOzR8bnNAhRD9RF8vQCPDa3QSFaTcIeg
has assertion: a(CHEBI:aldosterone) -> r(HGNC:EGR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.267+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:aldosterone) -> r(HGNC:EGR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18555797

3
value: Transactivated genes in HBMEC exposed to aldosterone (107 M) for 6 h by gene array
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18555797

RATV6xVf3AJPgZQ7kdOmIK63 VBR2zIiPxmEaqfHPySn0
has assertion: tscript(p(HGNC:E2F6)) -| tscript(p(HGNC:E2F1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.277+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:E2F6)) -| tscript(p(HGNC:E2F1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18562691

6
value: During hypoxia (CoCl(2), 800 microM)-induced human embryonic kidney 293 cell apoptosis, E2F6 expression was down-regulated with concurrent increases in E2F1 expression and transactivation. E2F6 overexpression abrogated hypoxia-induced apoptosis and alteration of E2F1. Conversely, specific knockdown of E2F6 by small interfering RNA had opposite effects. Chromatin immunoprecipitation assay confirmed that E2F6 regulated E2F1 expression through the transrepression of E2F1 promoter. Interestingly, E2F1 transactivation and apoptosis induced by hypoxia in cells stably expressing E2F1 were inhibited by E2F6 overexpression, suggesting that the inhibitory effects of E2F6 are not only mediated by the repression of E2F1 promoter.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18562691

RAY1hZhJMOlr9itUdeq0Fuh4E-isHkiLqqjXBE6E2ydjU
has assertion: p(MGI:Nr1d1) -> p(MGI:Cyp7a1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.279+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Nr1d1) -> p(MGI:Cyp7a1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18565334

4
value: Expression of CYP7A1, the rate-limiting enzyme of the neutral pathway, is decreased in livers of Rev-erbalpha-deficient mice, whereas adenovirus-mediated hepatic Rev-erbalpha overexpression induces its expression. Moreover, bile acid feeding resulted in a more pronounced suppression of hepatic CYP7A1 expression in Rev-erbalpha-deficient mice.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18565334

RAV30ZdnHKkh9b-jRnMbwYrltQCDl4wXiAmoqH5kmjduA
has assertion: a(CHEBI:acrolein) -| (a(CHEBI:lipopolysaccharide) -> tscript(complex(NCM:"Nfkb Complex")))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.282+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:acrolein) -| (a(CHEBI:lipopolysaccharide) -> tscript(complex(NCM:"Nfkb Complex")))
label: a(CHEBI:lipopolysaccharide) -> tscript(complex(NCM:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18566440

4
value: Acrolein decreases NF-kB activation in vivo - NF-kBp65 activity in nuclear extracts was markedly enhanced after LPS challenge, as expected. Moreover, both basal and LPS-induced NF-kBp65 activity was significantly reduced following exposure to acrolein compared with exposure to room air.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18566440

RAa5sAwV7IZoyanG07urRS wO5fb8b6p4551H8z13Jmec
has assertion: p(HGNC:F2) -> bp(GO:"platelet activation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.286+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:F2) -> bp(GO:"platelet activation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18574670

3
value: Fig. 2 Activation of platelets by convulxin (open triangles, n = 5), thrombin (closed circles, n = 6), PAF (open circles, n = 6) and ADP (closed triangles, n = 3).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18574670

RAWiQb0L1J03G12oNiV2DwzupwcUMazJj0unYy 2jodFI
has assertion: tscript(p(MGI:Foxo1)) -> sec(a(CHEBI:cholesterol))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.292+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Foxo1)) -> sec(a(CHEBI:cholesterol))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18587407

5
value: Disinhibition of the forkhead transcription factor FoxO1, increases expression of the biliary cholesterol transporters Abcg5 and Abcg8, resulting in an increase in biliary cholesterol secretion.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18587407

RAYouwlrY4G8H7uSVv5mLQhH4pZPPxftLsHleI yL2VH0
has assertion: complex(p(HGNC:TRIM28),g(HGNC:CDK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.295+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:TRIM28),g(HGNC:CDK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18590578

3
value: Phosphorylation of TIF1beta/Ser473 coincides with the induction of cell cycle gene cyclin A2 at the S-phase. Interestingly, chromatin immunoprecipitation demonstrated that the promoter of cyclin A2 gene is occupied by TIF1beta and that such occupancy is inversely correlated with Ser473 phosphorylation. Additionally, when HP1beta was co-expressed with TIF1beta/S473A, but not TIF1beta/S473E, the colocalization of TIF1beta/S473A and HP1beta to the promoters of Cdc2 and Cdc25A was enhanced. Non-phosphorylated TIF1beta/Ser473 allowed greater TIF1beta association with the regulatory regions and the consequent repression of these genes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18590578

RAdYyP9aJRFIuT0 aVmz3O0LyPqMVzrZIEf72YnxWqFS4
has assertion: tscript(p(HGNC:TRIM28)) =| r(EGID:5424)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.298+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:TRIM28)) =| r(EGID:5424)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18590578

5
value: Phosphorylation of TIF1beta/Ser473 coincides with the induction of cell cycle gene cyclin A2 at the S-phase. Interestingly, chromatin immunoprecipitation demonstrated that the promoter of cyclin A2 gene is occupied by TIF1beta and that such occupancy is inversely correlated with Ser473 phosphorylation. Additionally, when HP1beta was co-expressed with TIF1beta/S473A, but not TIF1beta/S473E, the colocalization of TIF1beta/S473A and HP1beta to the promoters of Cdc2 and Cdc25A was enhanced. Non-phosphorylated TIF1beta/Ser473 allowed greater TIF1beta association with the regulatory regions and the consequent repression of these genes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18590578

RAc5Sk554 p0aUjlQHxxcnsdZAUs9YXJzV4Q33VF5xBBE
has assertion: tscript(p(HGNC:TRIM28)) =| r(HGNC:CDC25A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.299+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:TRIM28)) =| r(HGNC:CDC25A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18590578

5
value: Phosphorylation of TIF1beta/Ser473 coincides with the induction of cell cycle gene cyclin A2 at the S-phase. Interestingly, chromatin immunoprecipitation demonstrated that the promoter of cyclin A2 gene is occupied by TIF1beta and that such occupancy is inversely correlated with Ser473 phosphorylation. Additionally, when HP1beta was co-expressed with TIF1beta/S473A, but not TIF1beta/S473E, the colocalization of TIF1beta/S473A and HP1beta to the promoters of Cdc2 and Cdc25A was enhanced. Non-phosphorylated TIF1beta/Ser473 allowed greater TIF1beta association with the regulatory regions and the consequent repression of these genes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18590578

RAd-en9ESeERghL93Nt9EmOmrB yi5ogaVY1mV9KwI0 Q
has assertion: m(HGNC:MIR21) -| r(HGNC:RECK)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.300+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR21) -| r(HGNC:RECK)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18591254

4
value: Specific inhibition of miR-21 with antisense oligonucleotides leads to elevated levels of RECK and TIMP3 and therefore reduces MMP activities in vitro and in a human model of gliomas in nude mice.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18591254

RAXtx2V28dTb3-Agi3pNeyJ Ltnqwk0o2McvpZTE6 tmk
has assertion: a(SCHEM:"Oxidized Low Density Lipoprotein") -| r(HGNC:SLA)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.303+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Oxidized Low Density Lipoprotein") -| r(HGNC:SLA)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18597759

3
value: Table 4 -Genes uniquely regulated by oxLDL.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18597759

RAQkUC9A4BCu1g2kYVKmXdBOa0exz5h5AN RppTYlr5dc
has assertion: p(PFM:"Raf Family") -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.309+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFM:"Raf Family") -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18598699

3
value: Acute DSS exposure induced colon epithelial cell death in both wild-type and Raf KOIE mice; however, apoptosis was significantly higher in the absence of Raf expression following 1- and 4-day DSS treatment.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18598699

RAdQg2rRYL1jI5-hd7o35WRKQTqawxOGTWExz4cZe9g3Q
has assertion: tscript(p(HGNC:OTX2)) => r(HGNC:POU1F1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.329+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:OTX2)) => r(HGNC:POU1F1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18628516

5
value: Functional studies revealed that the wild-type and mutant OTX2 proteins localized to the nucleus and bound to the target sequences within the IRBP (interstitial retinoid-binding protein), HESX1 (HESX homeobox 1), and POU1F1 promoters. Furthermore, the wild-type OTX2 protein markedly transactivated the promoters of IRBP ( approximately 27-fold), HESX1 ( approximately 4.5-fold), and POU1F1 ( approximately 19-fold),
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18628516

RAS-Jx0AoZ-bDMXwLEQaydsidcmZVsAWivXfjEn axImE
has assertion: a(CHEBI:nicotine) -> r(HGNC:BIRC5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.337+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:nicotine) -> r(HGNC:BIRC5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18635526

3
value: Nicotine activates survivin gene transcription in A549 NSCLC cells by increasing the recruitment of E2F1 and the concomitant dissociation of Rb from the survivin promoter (7).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18635526

RAUILywxctkMT0WBt5O cAQJ7LvRmQDM4F1mtSYp 8exA
has assertion: kin(p(HGNC:EIF2AK3)) => p(HGNC:EIF2S1,pmod(P,S,52))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.344+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:EIF2AK3)) => p(HGNC:EIF2S1,pmod(P,S,52))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18650916

5
value: Activated PERK then phosphorylates the translation-initiation factor eIF2a, reducing the overall frequency of messenger RNA translation initiation. However, selected mRNAs, such as ATF4 mRNA, are preferentially translated in the presence of phosphorylated eIF2a. ATF4 activates the transcription of UPR target genes encoding factors involved in amino-acid biosynthesis, the antioxidative-stress response and apoptosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18650916

RAWCdCxSwA6vUcwYeziZiUQ55o6QR7dAREXaE0GEcv6K0
has assertion: p(PFM:"Akt Family",pmod(P,T,308)) => kin(p(PFM:"Akt Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.350+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFM:"Akt Family",pmod(P,T,308)) => kin(p(PFM:"Akt Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18650932

5
value: from full text Results - Collectively, these results indicate that PKCz is an upstream regulator of Akt activation by phosphorylating Ser124. To demonstrate that PKCz is actually required in vivo for the phosphorylation of Akt’s Ser473 and Thr308, we analysed these parameters in EFs WT and KO for PKCz
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18650932

RAfHcCVPVDIWfKrNH1tVMUAzmLWXaPexHhPC1QqEmSmss
has assertion: a(SCHEM:"LY 294002") -> r(HGNC:COL5A1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.358+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"LY 294002") -> r(HGNC:COL5A1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18652687

3
value: Table 1: Genes responsive to PI3K, mTOR and p70S6K inhibitions in breast cancer cell lines.;MCF-7 breast cancer cell line, RPS6KB1-suppressed
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18652687

RAcWqHDGrUKk3 2tiI5jaMTObGjk9XyBsPK Sh7RFDGb0
has assertion: p(MGI:Tgfb1) -| p(MGI:Myc)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.372+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Tgfb1) -| p(MGI:Myc)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18662538

4
value: In keratinocytes and mammary epithelial cells, c-MYC downregulation is mediated by a TGF?-induced protein complex containing Smad3/4, p107, E2F4/5, and C/EBP? (Chen et al., 2002; Gomis et al., 2006b).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18662538

RAeX1FHOJvsDd1Ivog-52t7HlxaqSiAHCeJjFEygcf0cw
has assertion: p(HGNC:EGF) -> p(PFH:"CREB Family",pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.384+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> p(PFH:"CREB Family",pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18687633

4
value: TABLE V Survey of cell signaling proteins that show a reaction to EGF ligand stimulation over a 180-min time course - 500ng/mL EGF results
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18687633

RAXFVsZtcYyaVEd8yF28h0Wgg6aei5XkX4FZjmiEKauqo
has assertion: p(HGNC:EGF) -> p(HGNC:EGFR,pmod(P,Y,992))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.390+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> p(HGNC:EGFR,pmod(P,Y,992))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18687633

4
value: TABLE V Survey of cell signaling proteins that show a reaction to EGF ligand stimulation over a 180-min time course - 500ng/mL EGF results
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18687633

RAYywF2iY18xDvoQdauhnfx5PLZTLuzK4Zt9z-DreBLZQ
has assertion: p(HGNC:EGF) -> p(HGNC:KIT,pmod(P,Y,703))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.396+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> p(HGNC:KIT,pmod(P,Y,703))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18687633

4
value: TABLE V Survey of cell signaling proteins that show a reaction to EGF ligand stimulation over a 180-min time course - 500ng/mL EGF results
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18687633

RASCTaYRYpGU1e39U5baCFAtYXiKGU1XVqWBmhJSQ-olE
has assertion: p(HGNC:EGF) -> p(HGNC:RPS6KA2,pmod(P,S,380))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.400+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> p(HGNC:RPS6KA2,pmod(P,S,380))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18687633

4
value: TABLE V Survey of cell signaling proteins that show a reaction to EGF ligand stimulation over a 180-min time course - 500ng/mL EGF results
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18687633

RAVTKyAkSDtCtNwyQJw-gpZTti8PyT9cXDTdtdJXxrntw
has assertion: p(HGNC:EGF) -> p(HGNC:SHC1,pmod(P,Y,416))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.404+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> p(HGNC:SHC1,pmod(P,Y,416))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18687633

4
value: TABLE V Survey of cell signaling proteins that show a reaction to EGF ligand stimulation over a 180-min time course - 500ng/mL EGF results
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18687633

RAdtjWfAFq5CbytxOob47Pzx4nKF-FnbQRDVgYjMXnPmk
has assertion: a(CHEBI:metformin) -> p(MGI:Ucp2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.408+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:metformin) -> p(MGI:Ucp2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18687824

3
value: We conclude that metformin treatment leads to the overexpression of UCP2 in adipocytes to minimize the oxidative stress that is probably due to the inhibition of respiration caused by the drug.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18687824

RAWXhkNccV1dESTezuBYkBIYj21-6mZhExGNSt0VUtpyI
has assertion: p(HGNC:BSG) -> p(HGNC:TNF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.413+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:BSG) -> p(HGNC:TNF)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18691053

4
value: In vitro, treatment with siRNA for EMMPRIN hindered the induction of MMP-9 and MT1- MMP as well as of various cytokines such as interleukin-6 or TNF-alpha indicating a role for EMMPRIN far beyond simple MMP induction [31,32].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18691053

RAQlT4 oPJ00dwUUxv2nJ8GFF2OUiW2RlmHM-4xcCwmbk
has assertion: a(SCHEM:"Benzo(a)perylene") -> p(HGNC:PTGS2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.419+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Benzo(a)perylene") -> p(HGNC:PTGS2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18697742

3
value: benzo[a]pyrene (B[a]P), induce COX-2 expression in lymphocytes, epithelial cells, and fibroblasts (9–11).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18697742

RAQubbNpY4iLZENvs3eUSGhYeQjV96 lU0TaZU4Qn3FIo
has assertion: a(SCHEM:"Benzo(a)perylene") -> p(HGNC:PTGS2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.420+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Benzo(a)perylene") -> p(HGNC:PTGS2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18697742

3
value: benzo[a]pyrene (B[a]P), induce COX-2 expression in lymphocytes, epithelial cells, and fibroblasts (9–11).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18697742

RAUTiVP9M4cgXSDkqSym0B2T6QTi42a3Dg5VWksvVfjjo
has assertion: p(HGNC:HMGB1) -> bp(GO:angiogenesis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.421+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:HMGB1) -> bp(GO:angiogenesis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18701469

3
value: HMGB1 is also found extracellularly after passive release by necrotic cells or through active secretion from stimulated inflammatory cells (19). In the extracellular environment, this alarmin initiates proinflammatory responses to coordinate repair of damaged tissue through recruitment of leukocytes and stimulation of angiogenesis (19–22).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18701469

RAXjwYeVfc58 yhITGY ac9j1cmgNlv5VxL3v77l7AV6M
has assertion: bp(GO:"inflammatory response") -> sec(p(HGNC:CAMP))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.422+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"inflammatory response") -> sec(p(HGNC:CAMP))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18701469

4
value: Like other alarmins, hCAP-18/LL-37 is constitutively secreted by a variety of immune and epithelial cells and is elevated in response to inflammation and tissue injury (13).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18701469

RAQM yYYi77dLqxPW6WnS6x74NQKRiMmkBO1Ni7K8XYVg
has assertion: complex(p(HGNC:ATF5),g(HGNC:ID1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.426+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:ATF5),g(HGNC:ID1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18701499

3
value: The differential expressed genes from the functional effects of ATF5 were examined by array profiling. Over a hundred genes were identified, among which ID1 contains the ATF/CREB target binding sequences within its promoter region. An inverse relationship between ATF5 expressions with ID1 transcriptions was verified in HCC (P = 0.019), and a direct interaction of ATF5 on the promoter of ID1 was further demonstrated from electromobility shift assay.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18701499

RAS48x9aKtApbiVYKlqJsxm84TY-TWioit-8UGalZQN Q
has assertion: a(CHEBI:glutathione) -> cat(p(PFH:"GPX Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.432+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glutathione) -> cat(p(PFH:"GPX Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18705745

4
value: However, this detoxification process can be overwhelmed in some circumstances. One such circumstance is the depletion of mitochondrial, reduced glutathione. Normally, glutathione peroxidase plays a key role in H2O2 detoxification, as liver mitochondria do not have catalase. However, glutathione peroxidase needs adequate amounts of reduced glutathione in the mitochondrial matrix to detoxify H2O2. The depletion of mitochondrial glutathione below a critical threshold can impair mitochondrial H2O2 detoxification, which can trigger mitochondrial dysfunction, mitochondrial permeability transition (MPT) and cell death [22].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18705745

RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY
has assertion: a(CHEBI:glutathione) -| path(SDIS:"mitochondrial damage")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.434+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glutathione) -| path(SDIS:"mitochondrial damage")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18705745

2
value: However, this detoxification process can be overwhelmed in some circumstances. One such circumstance is the depletion of mitochondrial, reduced glutathione. Normally, glutathione peroxidase plays a key role in H2O2 detoxification, as liver mitochondria do not have catalase. However, glutathione peroxidase needs adequate amounts of reduced glutathione in the mitochondrial matrix to detoxify H2O2. The depletion of mitochondrial glutathione below a critical threshold can impair mitochondrial H2O2 detoxification, which can trigger mitochondrial dysfunction, mitochondrial permeability transition (MPT) and cell death [22].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18705745

RARAq7Gr2LbQKqmuLenG5za8ZDTKQo2zIj8 x8U1s8WJA
has assertion: cat(complex(NCH:"proton-transporting ATP synthase complex")) -> a(SCHEM:"Adenosine triphosphate")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.435+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(complex(NCH:"proton-transporting ATP synthase complex")) -> a(SCHEM:"Adenosine triphosphate")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18705745

3
value: The ??m serves as a reservoir of potential energy. When cells need energy, the rise in ADP levels within the mitochondria induces the re-entry of protons into the mitochondrial matrix through the membrane-spanning F0 portion of the ATP synthase complex (also referred to as the 'complex V of the MRC'). This re-entry of protons partially dissipates the ??m, thus liberating energy, which is used by the F1 portion of ATP synthase to phosphorylate ADP into ATP (Figure 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18705745

RAUtIfmNIb5W4OgXj-erlNXa9bDGboHxXyJ4L8EtbC4qk
has assertion: tscript(p(MGI:Meis2)) => r(MGI:Dlx5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.438+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Meis2)) => r(MGI:Dlx5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18706405

5
value: Meis2 and Islet1 proteins can bind and activate reporter gene transcription via the I56ii enhancer sequence......I56i and I56ii in the Dlx5/6 cluster.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18706405

RAafBN6kskG3ZYwJGwcb3i8VFLZRyv6s66qwdy5PKdyV4
has assertion: path(SDIS:"Inflammatory Bowel Disease") -> p(HGNC:NFATC2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.440+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"Inflammatory Bowel Disease") -> p(HGNC:NFATC2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18710929

3
value: Figure 1. Enhanced expression of NFATc2 transcription factors in patients with IBDs compared with control patients. (A) Immunohistochemistry for NFATc2 expression. Colon cross sections were incubated with NFATc2-specific antibodies and analyzed by microscopy. An increased expression of NFATc2 was observed in sections from UC and CD patients compared with control patients.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18710929

RAd7iOvJbCf0MsY61UMFRQQeV7OH0AyEUz5zV 1TW4kUw
has assertion: p(MGI:Prdm16) => tscript(p(MGI:Ppara))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.442+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Prdm16) => tscript(p(MGI:Ppara))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18719582

5
value: PRDM16 binds and activates the transcriptional function of PPARalpha
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18719582

RAeST8-IE6sF8Bg9wb4LuXGCC2JJQK KV78ID0MC6iS8Y
has assertion: p(MGI:Cpt1c) -> path(SDIS:"food intake")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.444+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Cpt1c) -> path(SDIS:"food intake")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18719599

3
value: CPT1c knockout (KO) mice have lower food intake, weigh less and have less body fat, consistent with the role as an energy-sensing malonyl-CoA target. Paradoxically, CPT1c protects against the effects of a high-fat diet. CPT1cKO mice exhibit decreased rates of fatty acid oxidation, consistent with their increased susceptibility to diet-induced obesity. Cpt1c is the neuronal CPT1 enzyme, the rate limiting enzyme of fatty acid beta oxidation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18719599

RAeDlzpdbrJlskByFF30lv90CULdpYyUfz0KF6XD9aUDo
has assertion: cat(p(HGNC:FASN)) -| a(SCHEM:"Malonyl coenzyme A")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.446+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:FASN)) -| a(SCHEM:"Malonyl coenzyme A")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18719599

4
value: The cellular malonyl-CoA level is determined by its rate of synthesis, catalyzed by acetyl-CoA carboxylase (ACC) {Official Gene Symbols: ACACA, ACACB}, and rate of removal, by fatty acid synthase (FAS).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18719599

RAbJL9YLjx7C-Y847bcyGnAA06uVF5lHTSr GOnFJbAUo
has assertion: kin(p(PFH:"RAF Family")) -> kin(p(PFH:"MEK1/2 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.451+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"RAF Family")) -> kin(p(PFH:"MEK1/2 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18725993

6
value: Growth factor and other survival signals are transduced through receptor tyrosine kinases via adaptor proteins (such as GRB2 and the guanine-nucleotide exchange factor SOS) and activate Ras and its downstream targets, Raf and MEK1/2, which results in the activation of ERK1/2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18725993

RAfa2bD 60NQs5l bQIy1SiDfb97nCWUQcNnO4VCisbdM
has assertion: bp(GO:"response to hypoxia") -> p(HGNC:NOS3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.456+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(HGNC:NOS3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18728656

3
value: hypoxia-induced AMPK activation of endothelial NOS (eNOS) drives angiogenesis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18728656

RAR059l5Q q5B9BrfmMnN7Fu3t2JhjZte7j4LF7pRYoOA
has assertion: gtp(p(HGNC:RAC1)) -> tscript(p(PFH:"SMAD Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.461+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:RAC1)) -> tscript(p(PFH:"SMAD Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18760941

6
value: We also show that the Smad site in the CTGF/CCN2 promoter is responsive to both Rac1 inhibition and cytochalasin D treatment, suggesting a role of TGFbeta/Smad signaling in mediating the effects of actin dynamics and Rac1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18760941

RAW5T2IL s7jGUvlyDc-wrwdBmBGRzYlhtFa fwUhYtfI
has assertion: path(SDIS:"food intake") -> r(HGNC:CEBPA)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.462+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"food intake") -> r(HGNC:CEBPA)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18765514

3
value: During caloric restriction, adipose tissue C/EBPalpha mRNA levels were reduced in subjects with the metabolic syndrome (P = 0.024) and correlated to metabolic parameters.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18765514

RAYFJTUwAdl51CkHjbbpL7IhZMU-jAHubbhMYSYfYZpUI
has assertion: p(MGI:Scarb1) -| path(SDIS:"Atherosclerotic lesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.468+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Scarb1) -| path(SDIS:"Atherosclerotic lesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18769226

3
value: However, bone marrow transplantation experiments have demonstrated that macrophage-specific SR-BI deficiency leads to increased atherosclerotic lesions in Apoe/ mice [29].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18769226

RAXC850aGdMMATo8W0eAuDDv8AfMqGDtXxKoJRlrKBwGc
has assertion: tscript(p(HGNC:NR0B2)) -| m(HGNC:MIR433)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.472+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:NR0B2)) -| m(HGNC:MIR433)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18776219

5
value: Estrogen related receptor (ERRgamma, NR3B3) robustly activated miR-433 and miR-127 promoter reporters through ERRE, which was transrepressed by SHP.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18776219

RAWen4L5ARz0QTyIO9jdy9hr1DyxguSWSPxxeDukWsAtA
has assertion: a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ccr5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.484+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ccr5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18787176

3
value: Bacterial load in the lungs, the lesions associated with infection and gene expression profiling was performed by comparing normal lungs tissue to lungs from mice collected at 20, 40 and 100 days after aerosol infection with the H37Rv strain of M. tuberculosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18787176

RAdx7QbVkh6Z2gJl7Q0h6uMQyXAK2L4Twra4u9DigeXTs
has assertion: a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ctss)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.494+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ctss)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18787176

3
value: Bacterial load in the lungs, the lesions associated with infection and gene expression profiling was performed by comparing normal lungs tissue to lungs from mice collected at 20, 40 and 100 days after aerosol infection with the H37Rv strain of M. tuberculosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18787176

RAdmwAnkKKnez ri3csVJy-FZdl7CEOp8qEhAEiH0EeYU
has assertion: a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ms4a6d)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.503+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ms4a6d)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18787176

3
value: Bacterial load in the lungs, the lesions associated with infection and gene expression profiling was performed by comparing normal lungs tissue to lungs from mice collected at 20, 40 and 100 days after aerosol infection with the H37Rv strain of M. tuberculosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18787176

RAfYnVfroLeVJVc1jzE-F7dT1sy2cAKwFI0Wr4LNEFlck
has assertion: a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ncf1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.506+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ncf1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18787176

3
value: Bacterial load in the lungs, the lesions associated with infection and gene expression profiling was performed by comparing normal lungs tissue to lungs from mice collected at 20, 40 and 100 days after aerosol infection with the H37Rv strain of M. tuberculosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18787176

RAXJhbSqf668YG1m57yaa-TqDno81eE GGqekZ-CoDPLI
has assertion: a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ncf1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.508+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Ncf1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18787176

3
value: Bacterial load in the lungs, the lesions associated with infection and gene expression profiling was performed by comparing normal lungs tissue to lungs from mice collected at 20, 40 and 100 days after aerosol infection with the H37Rv strain of M. tuberculosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18787176

RAVdGSv3vFqEQlmwsstMV7JdkUsep718jLo4yihh05IzI
has assertion: a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Slc26a4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.510+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Mycobacterium tuberculosis, ext.") -> r(MGI:Slc26a4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18787176

3
value: Bacterial load in the lungs, the lesions associated with infection and gene expression profiling was performed by comparing normal lungs tissue to lungs from mice collected at 20, 40 and 100 days after aerosol infection with the H37Rv strain of M. tuberculosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18787176

RATnJU5tHmcx6s LmrjHtZSOwC34yU4AOi242bgNg3Glg
has assertion: tscript(p(HGNC:KAT2B)) -> r(HGNC:MMP9)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.565+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:KAT2B)) -> r(HGNC:MMP9)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18790699

5
value: We demonstrate that multiple transcriptional co-activators are involved in MMP-9 promoter activation, including CBP/p300, PCAF, CARM1 and GRIP1. Furthermore, enhancement of MMP-9 promoter activity requires the histone acetyltransferase activity of PCAF but not that of CBP/p300, and the methyltransferase activity of CARM1. More importantly, these co-activators are able to activate MMP-9 promoter activity independently, and function in a synergistic manner. Chromatin immunoprecipitation assays demonstrate that these co-activators associate with the endogenous MMP-9 promoter, and that siRNA knockdown of expression of these co-activators reduces endogenous MMP-9 expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18790699

RAQQLgC5Te9ZNu8cwyjxFarnPJp00muXbPpqW1UKJWAnE
has assertion: bp(GO:"response to UV-B") -| r(HGNC:ABCD3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.573+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to UV-B") -| r(HGNC:ABCD3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18797132

3
value: Microarray analysis identified 21 genes as UVB-responsive genes with a peak at 24 h in 6 subjects, and real-time PCR validated the significant down-regulation of 9 (ABCB10, ATF1, ABCD3, TANK, FAS, SLC30A9, CHUK, CASP1, and ABCE1) out of the 21 genes in 11 subjects.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18797132

RAV0JciDm0IbzmjhzZ42uRE9OY8sreEEzcr9kOqa9TX5c
has assertion: bp(GO:"response to UV-B") -| r(HGNC:ABCE1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.574+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to UV-B") -| r(HGNC:ABCE1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18797132

3
value: Microarray analysis identified 21 genes as UVB-responsive genes with a peak at 24 h in 6 subjects, and real-time PCR validated the significant down-regulation of 9 (ABCB10, ATF1, ABCD3, TANK, FAS, SLC30A9, CHUK, CASP1, and ABCE1) out of the 21 genes in 11 subjects.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18797132

RAVL6YNvXGXlj5OXmJkrjXTfLoDBavZoa4VS-VgAyJeBk
has assertion: bp(GO:"response to UV-B") -| r(HGNC:CASP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.578+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to UV-B") -| r(HGNC:CASP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18797132

3
value: Microarray analysis identified 21 genes as UVB-responsive genes with a peak at 24 h in 6 subjects, and real-time PCR validated the significant down-regulation of 9 (ABCB10, ATF1, ABCD3, TANK, FAS, SLC30A9, CHUK, CASP1, and ABCE1) out of the 21 genes in 11 subjects.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18797132

RAbHilYHNb0R2wiK9y0AmD3ZQ3CAvhF15NOaMiVX9dp3k
has assertion: bp(GO:"response to UV-B") -| r(HGNC:FAS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.579+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to UV-B") -| r(HGNC:FAS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18797132

3
value: Microarray analysis identified 21 genes as UVB-responsive genes with a peak at 24 h in 6 subjects, and real-time PCR validated the significant down-regulation of 9 (ABCB10, ATF1, ABCD3, TANK, FAS, SLC30A9, CHUK, CASP1, and ABCE1) out of the 21 genes in 11 subjects.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18797132

RAQ JDJNJhK8dSHssIZYbJAK2JWPNGYX1pM4MIYOVoJdU
has assertion: p(MGI:Arx) -> r(MGI:Cxcr4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.591+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Arx) -> r(MGI:Cxcr4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18799476

4
value: Supplementary Table 1. Genes with altered expression, as defined by FDR-adjusted p < 0.05 and >=1/5 or <=-1 log2-fold change, in subpallium from Arx-/Y; Pou3f4-Cre+ mice when compared to genes expressed in the subpallium of Arxwt/Y; Pou3f4-Cre+ mice. {4 WT and 4 KO mice used in analysis}
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18799476

RAfxwiwZJlhqtVn mvDh0F13n14VU 6f6ihogX4SHsO2I
has assertion: p(MGI:Arx) -> r(MGI:Foxp1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.594+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Arx) -> r(MGI:Foxp1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18799476

4
value: Supplementary Table 1. Genes with altered expression, as defined by FDR-adjusted p < 0.05 and >=1/5 or <=-1 log2-fold change, in subpallium from Arx-/Y; Pou3f4-Cre+ mice when compared to genes expressed in the subpallium of Arxwt/Y; Pou3f4-Cre+ mice. {4 WT and 4 KO mice used in analysis}
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18799476

RAUAbzw5QdjiXQlLwi-Eqfjzm5Kyk8E lNn8ZjS8fizz0
has assertion: p(MGI:Arx) -> r(MGI:Oprm1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.597+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Arx) -> r(MGI:Oprm1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18799476

4
value: Supplementary Table 1. Genes with altered expression, as defined by FDR-adjusted p < 0.05 and >=1/5 or <=-1 log2-fold change, in subpallium from Arx-/Y; Pou3f4-Cre+ mice when compared to genes expressed in the subpallium of Arxwt/Y; Pou3f4-Cre+ mice. {4 WT and 4 KO mice used in analysis}
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18799476

RARrlOtBwcRLVUGrRS2cT 3rQxkFzT7-ExHPsUb 9gcxQ
has assertion: p(MGI:Arx) -| r(MGI:Aplp2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.604+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Arx) -| r(MGI:Aplp2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18799476

4
value: Supplementary Table 1. Genes with altered expression, as defined by FDR-adjusted p < 0.05 and >=1/5 or <=-1 log2-fold change, in subpallium from Arx-/Y; Pou3f4-Cre+ mice when compared to genes expressed in the subpallium of Arxwt/Y; Pou3f4-Cre+ mice. {4 WT and 4 KO mice used in analysis}
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18799476

RAWFDuFbazaQWffrF1JBgaWqZG4tByoTAdO5ZVfB 9djs
has assertion: p(MGI:Arx) -| r(EGID:207667)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.618+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Arx) -| r(EGID:207667)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18799476

4
value: Supplementary Table 1. Genes with altered expression, as defined by FDR-adjusted p < 0.05 and >=1/5 or <=-1 log2-fold change, in subpallium from Arx-/Y; Pou3f4-Cre+ mice when compared to genes expressed in the subpallium of Arxwt/Y; Pou3f4-Cre+ mice. {4 WT and 4 KO mice used in analysis}
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18799476

RAeMGUCnRqAVI1e0BFeQwT-VDYBarX4Mg5LZWgRgCpt5Q
has assertion: p(MGI:Arx) -| r(MGI:Sst)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.629+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Arx) -| r(MGI:Sst)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18799476

4
value: Supplementary Table 1. Genes with altered expression, as defined by FDR-adjusted p < 0.05 and >=1/5 or <=-1 log2-fold change, in subpallium from Arx-/Y; Pou3f4-Cre+ mice when compared to genes expressed in the subpallium of Arxwt/Y; Pou3f4-Cre+ mice. {4 WT and 4 KO mice used in analysis}
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18799476

RAX9j6U5fZKTCs5NSTo4G0BLYG CaTCd1bhqcwvNfi pE
has assertion: p(HGNC:SLC25A4) -| path(SDIS:Myopathy)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.651+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:SLC25A4) -| path(SDIS:Myopathy)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18809618

3
value: Specific mis-sense mutations in the human Ant1 cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), mitochondrial myopathy and cardiomyopathy, which are commonly manifested by fractional mitochondrial DNA (mtDNA) deletions.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18809618

RAfGBPZS0-Ms-PMWbGwrSSB00yyj4DWNZEST3Fz6HK2Z8
has assertion: a(CHEBI:lipopolysaccharide) -> sec(p(HGNC:SAA3P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.661+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> sec(p(HGNC:SAA3P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18820689

4
value: We also found that both S100A8 and lipopolysaccharide (LPS) stimulated SAA3 protein secretion into LCM. (By WB, in lung endothelial cells)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18820689

RAbAcVZs0dL8Ypar7PAk1EenYruJr72Wm7g0WrxZnXh Y
has assertion: p(HGNC:TLR4) -| p(HGNC:NFKBIA,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.662+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TLR4) -| p(HGNC:NFKBIA,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18820689

4
value: We found that SAA3–GST induced phosphorylation of I?B-? in macrophages derived from wild-type mice but not in those derived from TLR4 knockout (TLR4–/–) mice (Fig. 3f).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18820689

RAYnwse3dj3usR497dFdVbVKCcc4Pk E4Z5nwkQtZkSiQ
has assertion: a(CHEBI:fulvestrant) -| tscript(p(HGNC:ESR1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.663+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:fulvestrant) -| tscript(p(HGNC:ESR1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18824559

4
value: Similarly, treatment with ICI 182780 (Fulvestrant ) resulted in a dose-dependent decrease in ESR1/ERE transactivation in both cell lines (Fig. 1D).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18824559

RAQN-i2NHk3LRDq1HKJrkFVjQFy6IpjmYJLkk10rtgY98
has assertion: a(CHEBI:nicotine) -| p(HGNC:CDH1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.670+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:nicotine) -| p(HGNC:CDH1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18844224

3
value: Figure 5a shows that treatment of A549 cells with nicotine causes an increase in the levels of mesenchymal proteins like fibronectin and vimentin with a concomitant downregulation of epithelial markers E-cadherin and b-catenin. Interestingly, nicotine induced EMT in breast cancer cell lines like MCF-7 and MDA-MB-468; this is significant as smoking has been correlated with increased metastasis of breast cancers.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18844224

RAfCnwJFAqj7tNIO8cJVGlO2sYtqNek7tkrDMOkaFQEIw
has assertion: a(CHEBI:nicotine) -> p(HGNC:CDH2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.675+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:nicotine) -> p(HGNC:CDH2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18844224

3
value: It was found that the maximal effect of nicotine was observed at 1 lM concentration, whereas 0.1 lM nicotine also induced EMT like changes (Fig. 5b)... levels of fibronectin, vimentin and N-cadherin were elevated
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18844224

RAWocn PArBRFb1bO3i PI2bDBW3PUHGg56cVGpYp4y-k
has assertion: a(CHEBI:nicotine) -> tloc(p(HGNC:TJP1),GOCCACC:"GO:0016020",GOCCACC:"GO:0005737")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.681+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:nicotine) -> tloc(p(HGNC:TJP1),GOCCACC:"GO:0016020",GOCCACC:"GO:0005737")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18844224

4
value: when the cells were treated with 1 lM nicotine for 48 or 72 hr, diffuse ZO-1 staining was observed, characteristic of a migratory mesenchymal phenotype (Fig. 7, middle and bottom panel).26,27 Furthermore, the overall intensity of the ZO-1 staining was reduced.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18844224

RAQE5SNtGqcqRiOAvyFRh oXd8RMxDGUpO35D2VwGmE k
has assertion: tscript(p(HGNC:PLAG1)) => r(HGNC:ABCC6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.684+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:PLAG1)) => r(HGNC:ABCC6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18850323

5
value: we identified ABCC6 as a target gene for transcriptional induction by PLAG1 and PLAGL1, transcription factors from the PLAG family of cell cycle progression-related DNA-binding proteins. Both these factors are shown to bind to the same single consensus-binding element in the ABCC6 proximal promoter in cell lines of hepatic and renal origin by reporter gene assay, electrophoretic mobility shift assay and chromatin immunoprecipitation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18850323

RAYej7EBJ1q ssdF62A9piqjn2MJt68b5h6rPSRFp9xjk
has assertion: tscript(p(HGNC:PLAGL1)) => r(HGNC:ABCC6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.685+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:PLAGL1)) => r(HGNC:ABCC6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18850323

5
value: we identified ABCC6 as a target gene for transcriptional induction by PLAG1 and PLAGL1, transcription factors from the PLAG family of cell cycle progression-related DNA-binding proteins. Both these factors are shown to bind to the same single consensus-binding element in the ABCC6 proximal promoter in cell lines of hepatic and renal origin by reporter gene assay, electrophoretic mobility shift assay and chromatin immunoprecipitation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18850323

RAcp87urejKWr5zCtSmGIgMzgbZfVGjshJoJxvNtOs2UI
has assertion: a(CHEBI:"leukotriene B4") -> r(HGNC:TNF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.696+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"leukotriene B4") -> r(HGNC:TNF)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18852255

3
value: In cultured monocytes, LTB4 upregulated IL-6, MCP-1, and TNF-a expression at 3 h (Real Time-PCR). U-75302, Ly-2552837, and PTX significantly diminished LTB4-mediated gene overexpression (Figure 5A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18852255

RAZbWxH-EKwIm0bG3DLiN-a gNlrP-gl-6YHKhwC jMOk
has assertion: a(CHEBI:"leukotriene B4") -> r(HGNC:TNF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.713+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"leukotriene B4") -> r(HGNC:TNF)
label: tscript(complex(NCH:"Nfkb Complex")) -> (a(CHEBI:"leukotriene B4") -> r(HGNC:TNF))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18852255

5
value: Pretreatment with NF-kB inhibitors MG-132, Bay-117032, and parthenolide significantly decreased IL-6, MCP-1, and TNF-a mRNA induction caused by LTB4 in monocytes (Figure 5B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18852255

RARZzPrUap73hVV-HWnqw94hA65CxWrfSdaBT4QPOn3eY
has assertion: p(MGI:Abcg1) -| a(CHEBI:cholesterol)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.719+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Abcg1) -| a(CHEBI:cholesterol)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18852364

3
value: Abcg1/ macrophages accumulate sterols, notably 7-ketocholesterol and desmosterol after feeding of a high-cholesterol diet (Table) as well as 27-OH cholesterol (0.260.04 versus 0.440.04 ng/mg protein in macrophages from WT and Abcg1/ mice fed a chow diet, respectively; P0.05).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18852364

RAZZrsgyKiOuwIvAZFwIOi31BrpAiBXLFsCItizRPVtEI
has assertion: p(HGNC:ENO1) -| r(HGNC:CDKN1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.720+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ENO1) -| r(HGNC:CDKN1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18852884

4
value: Senescent fibroblasts exhibited enhanced expression of phosphorylated and acetylated p53, and cyclin-dependent kinase inhibitor, p21. Together, these results demonstrated that knockdown of endogenous MBP-1 is involved in cellular senescence of HFF through p53-p21 pathway.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18852884

RAXkBh1uBkQfxbtuSzvHYShpj3kZXGo02JVt2P67Kad5o
has assertion: p(HGNC:ENO1) -> r(EGID:5424)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.726+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ENO1) -> r(EGID:5424)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18852884

4
value: Table 1. Genes differentially expressed in MBP-1 depleted HFF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18852884

RASb9qkjhVwIKNQ-4zX K9ogbOzKFjy6YYesIikq30XTg
has assertion: p(HGNC:ENO1) -> r(HGNC:CDKN3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.728+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ENO1) -> r(HGNC:CDKN3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18852884

4
value: Table 1. Genes differentially expressed in MBP-1 depleted HFF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18852884

RAcbTuct82N3Hs1E8wsHndhZnY8vm9gB8D5M YcuArxY8
has assertion: p(HGNC:ENO1) -| r(HGNC:CDK6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.740+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ENO1) -| r(HGNC:CDK6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18852884

4
value: Table 1. Genes differentially expressed in MBP-1 depleted HFF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18852884

RASMufK2ddhsVsfOlfXeS-NCKD73RHA1K tel5wJJKbYA
has assertion: p(HGNC:FGFBP1) -| p(HGNC:FGF2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.746+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:FGFBP1) -| p(HGNC:FGF2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1885605

4
value: This protein, designated HBp17, was found to bind the heparin-binding peptide growth factors HBGF-1 and HBGF-2 in a noncovalent, reversible manner. In addition HBp17 was found to inhibit the biological activities of both HBGF-1 and HBGF-2. Both the binding and inactivation of HBGF-1 and HBGF-2 by HBp17 were abolished by heparin
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1885605

RAT6q79s-sR-KQQqDKctt5Xnzj844SRbV-eDCcXc8rFl4
has assertion: path(SDIS:Diabetes) negativeCorrelation r(RGD:Ckb)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.750+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:Diabetes) negativeCorrelation r(RGD:Ckb)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1887884

3
value: Quantitation of CK-M and CK-B mRNA levels on Northern blots with specific cDNA probes showed that, in diabetic hearts, CK-B mRNA levels represent only 19.8% of control levels and are more markedly depressed than CK-M mRNA levels
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1887884

RAZVLH8OmoeOyGwuJv22fN-PaaazudPU--R962oQCo2mk
has assertion: bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.755+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Accumulation of both HIF-1a and HIF-2a in response to hypoxia was demonstrated in vitro in human and mouse macrophages and macrophage cell lines and in vivo in TAMs, as well as in macrophages from healing wounds, inflamed rheumatoid synovium, and atherosclerotic lesions (Talks et al., 2000; Burke et al., 2002b; Mi et al., 2007; Griffiths et al., 2000; Crowther et al., 2001; Hollander et al., 2001; Distler et al., 2004; Vink et al., 2007; Onita et al., 2002; Koga et al., 2004; Bosco et al., 2008).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAaALumzRZ3-o xQ7 ZSEYVIqywZlvFL7E3eJkNUK0nys
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:CCL20)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.758+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:CCL20)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: CCL20 chemokine, a selective chemoattractant for iDCs, effector/memory T lymphocytes, and naive B cells (Schutyser et al., 2003) is an exception to this pattern, because it is induced by hypoxia in primary human monocytes (Bosco et al., 2006) and, to a lower extent, in macrophages (Battaglia et al., 2008).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RASPCuUZXjMrCvqJBi7QfS-NjvEhC-QP7icI2VrrBA2Wo
has assertion: bp(GO:"response to hypoxia") -| r(HGNC:CEBPA)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.760+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -| r(HGNC:CEBPA)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Down-regulation of several HIF-1 transcriptional cofactors, including CCAAT enhancer binding protein alpha (C/EBPa), CREB-binding protein (CBP), microphthalmia-associated transcription factor (MITF), and nuclear receptor co-activator 1 (NCOA1/ SRC-1), was also observed in hypoxic monocytes (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAQR9zZLOFKjyk0hIP -7JhDdKS8GA MRw3TKJxMSQzxY
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:TFPI2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.765+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:TFPI2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Furthermore, we reported that the tissue inhibitor of metalloproteinase 1 (TIMP1) and tissue factor pathway inhibitors 1 and 2 (TFPI1, 2), which reduce ECM degradation inhibiting cell migratory activity (Nagase et al., 2006) are up-regulated in hypoxic monocytes (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAbr6Rwfky3f024 tSqFB Yy zQOSn0SE Yo861wmgKDE
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:DUSP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.768+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:DUSP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Human monocytic cells exposed to in vitro hypoxia express higher levels of the MAPK phosphatase 1 (MKP-1), with consequent reversal of MAPK phosphorylation required for cell migration (Grimshaw and Balkwill, 2001), and of the regulator of G-protein signaling 1 (RGS1) (Bosco et al., 2006), a member of a new class of G-protein signaling deactivators which inactivates several chemotactic receptors consequently inhibiting chemoattractant-induced migration (Denecke et al., 1999).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAWOVsE650UieJKSMWzpWnjRIDDEbO4wD52eTVpRjlaD8
has assertion: bp(GO:"response to hypoxia") -| r(HGNC:CCL2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.781+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -| r(HGNC:CCL2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Monocyte exposure to hypoxia in vitro profoundly and differentially modulates the expression of a cluster of chemokine genes, with a characteristic dichotomy resulting in upregulation of those active on neutrophils, such as CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 (Metinko et al., 1992; Bosco et al., 2006), and in the inhibition of chemokines predominantly active on monocytes, macrophages, T lymphocytes, NK cells, basophils and/or DCs, such as CCL2, CCL8, CCL15, CCL18, CCL19, CCL23, and CXCL11 (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAYsCv3NHHRdLG 2hxWXw0Fv709LYHZaPsxrQPSCl6r84
has assertion: bp(GO:"response to hypoxia") -| r(HGNC:CCL23)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.782+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -| r(HGNC:CCL23)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Monocyte exposure to hypoxia in vitro profoundly and differentially modulates the expression of a cluster of chemokine genes, with a characteristic dichotomy resulting in upregulation of those active on neutrophils, such as CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 (Metinko et al., 1992; Bosco et al., 2006), and in the inhibition of chemokines predominantly active on monocytes, macrophages, T lymphocytes, NK cells, basophils and/or DCs, such as CCL2, CCL8, CCL15, CCL18, CCL19, CCL23, and CXCL11 (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAZB8VRJ-ZHxFyVBPQo0HE4UgWqIgynx5RBLSaECV384g
has assertion: bp(GO:"response to hypoxia") -| r(HGNC:CCL8)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.783+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -| r(HGNC:CCL8)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Monocyte exposure to hypoxia in vitro profoundly and differentially modulates the expression of a cluster of chemokine genes, with a characteristic dichotomy resulting in upregulation of those active on neutrophils, such as CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 (Metinko et al., 1992; Bosco et al., 2006), and in the inhibition of chemokines predominantly active on monocytes, macrophages, T lymphocytes, NK cells, basophils and/or DCs, such as CCL2, CCL8, CCL15, CCL18, CCL19, CCL23, and CXCL11 (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAaIX88lDSJL1-1tyJuXcIKJ4EhmAOSFWgWC8ae33Fh3k
has assertion: bp(GO:"response to hypoxia") -| r(HGNC:CXCL11)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.784+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -| r(HGNC:CXCL11)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Monocyte exposure to hypoxia in vitro profoundly and differentially modulates the expression of a cluster of chemokine genes, with a characteristic dichotomy resulting in upregulation of those active on neutrophils, such as CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 (Metinko et al., 1992; Bosco et al., 2006), and in the inhibition of chemokines predominantly active on monocytes, macrophages, T lymphocytes, NK cells, basophils and/or DCs, such as CCL2, CCL8, CCL15, CCL18, CCL19, CCL23, and CXCL11 (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAZK0xzhP1aexdQ-5IuhYlvFnl5Li4X6e9VlKRuwA0fgQ
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:CXCL2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.785+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:CXCL2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Monocyte exposure to hypoxia in vitro profoundly and differentially modulates the expression of a cluster of chemokine genes, with a characteristic dichotomy resulting in upregulation of those active on neutrophils, such as CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 (Metinko et al., 1992; Bosco et al., 2006), and in the inhibition of chemokines predominantly active on monocytes, macrophages, T lymphocytes, NK cells, basophils and/or DCs, such as CCL2, CCL8, CCL15, CCL18, CCL19, CCL23, and CXCL11 (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAekHdYs1Xb8Fa Z4YLmYYe2HyMzJ 3wOVC1MJaK55wVA
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:CXCL6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.787+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:CXCL6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Monocyte exposure to hypoxia in vitro profoundly and differentially modulates the expression of a cluster of chemokine genes, with a characteristic dichotomy resulting in upregulation of those active on neutrophils, such as CXCL2, CXCL3, CXCL5, CXCL6, and CXCL8 (Metinko et al., 1992; Bosco et al., 2006), and in the inhibition of chemokines predominantly active on monocytes, macrophages, T lymphocytes, NK cells, basophils and/or DCs, such as CCL2, CCL8, CCL15, CCL18, CCL19, CCL23, and CXCL11 (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RASck7cEH2zfyiPojrZZv0yGIooiLNamMLmDU5Z WiBos
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:SPP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.795+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:SPP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Most of these genes, including VEGF, adrenomedullin (ADM), coagulation factor III (F3), acid fibroblast growth factor 1 (FGF1), VEGF receptor-1 (FLT1), macrophage migration inhibitory factor (MIF), and osteopontin (SPP1), are similarly upregulated by hypoxia in primary human monocytes (Melillo et al., 1999; Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAaN1ZNiscyzkqX 4kLJ2BFDsTFXhI8m8Qkgc GcbyLSw
has assertion: bp(GO:"response to hypoxia") -> p(HGNC:TEK)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.800+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(HGNC:TEK)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: Recently, the tie-2 receptor for the proangiogenic factor, Ang2, was reported to be induced by hypoxia in monocytes and macrophages. This was shown to lead to a downregulation of IL-12 expression in Ang2-treated hypoxic cells (Murdoch et al., 2007).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAZRIxvArdyRfVWclwtthlYE TrSk-Nq0PmTHq2RiXEF8
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:MMP16)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.807+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:MMP16)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18926289

3
value: The expression of other members of the MMP family is deregulated in hypoxic monocytes, which show reduced levels of MMP25 and increased amounts of MMP1, MMP16, and MMP19, relative to the normoxic counterparts (Bosco et al., 2006).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18926289

RAZpQJSz3zNVJG2lUhHBD6M ouDlsNBQ5vwYoawVgfNBE
has assertion: bp(GO:"inflammatory response") -> p(PFH:"TGFB Family")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.809+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"inflammatory response") -> p(PFH:"TGFB Family")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1892646

3
value: Using immunohistochemical staining, we have examined lung sections of patients with advanced idiopathic pulmonary fibrosis (IPF), a disease characterized by chronic inflammation and fibrosis and demonstrated a marked and consistent increase in TGF-beta production in epithelial cells and macrophages when compared to patients with nonspecific inflammation and those with no inflammation or fibrosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1892646

RAWDaZdrlMtgCgxQo4WKFF5O0hxOlovbfenOlyLkjmQ0s
has assertion: path(SDIS:"Respiratory Syncytial Virus Infection") -> r(MGI:Hmox1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.820+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"Respiratory Syncytial Virus Infection") -> r(MGI:Hmox1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18931336

3
value: Figure 8. Suppression of antioxidant response element (ARE)-responsive antioxidant/detoxifying enzyme induction by RSV in Nrf22/2 mice.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18931336

RAbVNaLrx8bgbnC7WfFtWOILHo EeMjTFLne8tL69Dllc
has assertion: m(MGI:Mir140) -| r(MGI:Dcbld1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.835+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir140) -| r(MGI:Dcbld1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18945805

4
value: See TABLE 1. mRNAs repressed by miR-140 overexpression and derepressed by silencing of miR-140.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18945805

RAbMT94ucTJN2m2hOIiedQcXQ1M5WyS4mVwdXecGfeTXI
has assertion: m(MGI:Mir140) -| r(MGI:Epc1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.838+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir140) -| r(MGI:Epc1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18945805

4
value: See TABLE 1. mRNAs repressed by miR-140 overexpression and derepressed by silencing of miR-140.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18945805

RAUF5KXRNu0R box7ZM4AMaB1RysYJydE5UFdhZZx4sYM
has assertion: m(MGI:Mir140) -| r(MGI:Lrrcc1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.849+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir140) -| r(MGI:Lrrcc1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18945805

4
value: See TABLE 1. mRNAs repressed by miR-140 overexpression and derepressed by silencing of miR-140.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18945805

RAVeTTqhcYy4dRrrDQVGQ7q9jUTO7BS7G3Y jRoQp6vbs
has assertion: m(MGI:Mir140) -| r(MGI:Rbbp6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.857+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir140) -| r(MGI:Rbbp6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18945805

4
value: See TABLE 1. mRNAs repressed by miR-140 overexpression and derepressed by silencing of miR-140.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18945805

RAaMKNLl 2kjM5C7EJKoRcjWtV5GTv EYtQV-Iz1Q1xgA
has assertion: m(MGI:Mir140) -| r(MGI:S100a3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.859+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir140) -| r(MGI:S100a3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18945805

4
value: See TABLE 1. mRNAs repressed by miR-140 overexpression and derepressed by silencing of miR-140.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18945805

RAWcpaDyqXii7ytXLOB-xvEuPYOrWPodaPgzvxmMBsV0Y
has assertion: m(MGI:Mir140) -| r(MGI:Slc11a1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.861+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:Mir140) -| r(MGI:Slc11a1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18945805

4
value: See TABLE 1. mRNAs repressed by miR-140 overexpression and derepressed by silencing of miR-140.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18945805

RAWiaxy68J2okh0zF5sJt3-SBLf3qwwKlbTUbiC-R htw
has assertion: tscript(p(MGI:Bach1)) =| r(MGI:Hmox1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.876+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Bach1)) =| r(MGI:Hmox1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18948842

5
value: Furthermore, at baseline and in hyperoxia, chromatin immunoprecipitation (ChIP) revealed increased Bach1 binding to the HO-1 distal enhancers (DEs) in the neonates compared with adults. These data suggest that elevated levels of Bach1 may help to limit HO-1 induction in the newborn at baseline and in response to oxidative stress.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18948842

RARXzc123Kbv ig qiA2zNxdurjKzMyfYWV8nQ3Hz8yMg
has assertion: p(HGNC:S1PR1) -> p(HGNC:CDH3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.888+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:S1PR1) -> p(HGNC:CDH3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18973762

4
value: Overexpression of S1P1 in HEK293 cells markedly increases the expression level of P- and E-cadherin, but not ?- and ?-catenin, and induces cell–cell aggregation in a Ca2+ dependent manner (Lee et al., 1998).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18973762

RAbJhNyfHGujZLGhh-3MYrR6A6337dXBE-2Dwqz98t9VU
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:S1PR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.895+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:S1PR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18973762

3
value: S1P1 was first cloned from endothelial cells as an immediate early transcript induced by the tumor promoter phorbol 12-myristate 13-acetate (PMA) (Hla and Maciag, 1990).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18973762

RAZYO3PIYngcbDgJOrlrLQ42wH76FrHtCzy3wQd2CE Jo
has assertion: p(HGNC:S1PR1) -> bp(GO:"cell-cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.897+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:S1PR1) -> bp(GO:"cell-cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18973762

3
value: Transfection of human embryonic kidney 293 cells (HEK293), which express little if any endogenous S1P1, induces a network of cell–cell aggregates. This morphology resembles the network formation of differentiated endothelial cells, and is completely prevented by the chelating agent EGTA and C3 exotoxin, a specific inhibitor of the small GTPase Rho
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18973762

RAbOXoGrA EV6zpVmK6E4f1C3Yr6Ls--XSgu0fH7JnoAA
has assertion: complex(p(RGD:Fos),p(RGD:Jun)) -> bp(GO:"inflammatory response")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.905+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(RGD:Fos),p(RGD:Jun)) -> bp(GO:"inflammatory response")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18996472

5
value: AP1, together with the transcription factor Sp1, also mediates angiotensin II-induced inflammation in rats [24]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18996472

RAdAgAqWWPItlURA6NLGTwLF05n0NhV 0AK89n3LyOn7Q
has assertion: a(SCHEM:"Oxidized Low Density Lipoprotein") -> tscript(p(HGNC:NFKB1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.912+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Oxidized Low Density Lipoprotein") -> tscript(p(HGNC:NFKB1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/18996472

4
value: Activation of NF-?B by minimally modified LDL in endothelial cells was reported by Rajavashisth et al. [36], and by Cu2+-or cell-oxidized LDL in fibroblasts, endothelial cells, and smooth muscle cells by our group [37].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/18996472

RAdp3WTCFE50-H9jkgF2kHyWK4xWNv7 DSLTxOO1e QX8
has assertion: a(CHEBI:paclitaxel) -| path(SDIS:"tumor growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.920+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:paclitaxel) -| path(SDIS:"tumor growth")
label: p(MGI:Adam17) -| (a(CHEBI:paclitaxel) -| path(SDIS:"tumor growth"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19005493

4
value: ADAM10 and ADAM17 inhibitor in cell and animal models. This inhibitor also acts synergistically with the chemotherapeutic agent paclitaxel to reduce tumour volume in a mouse model of non-small-cell lung cancer103.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19005493

RAeWKO9YvI8cNqibLks0Qg2glkuT2coRpXNXpGqX1rbOU
has assertion: cat(p(HGNC:TLR5)) -> kin(p(HGNC:IRAK4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.930+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:TLR5)) -> kin(p(HGNC:IRAK4))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19006693

6
value: Indeed, all TLRs except TLR3 require IRAK-4 and MyD88 to signal
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19006693

RAc5cJ-GPoemS9ljgMq84 o41B3deh7DB19Tnce1jtUqA
has assertion: p(HGNC:IL4) -| p(HGNC:FCGR3A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.938+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL4) -| p(HGNC:FCGR3A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1900882

4
value: IL-4 induced the higher proliferation of CM-NK cells, but abolished their NK activity and decreased CD16 and CD56 Ag expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1900882

RATq-Gu-X62MOy0QoYNHnrjLg-ofvGiJPAPgtWPKNdCeU
has assertion: p(HGNC:WRN) -| a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.944+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:WRN) -| a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19011155

3
value: Compared with normal fibroblasts, both WSF1 cells and CSE-exposed fibroblasts significantly increased intracellular ROS production (Figure 6A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19011155

RAR54K7ruoa6OstJIYjc0hBn7AT9t8PZv2wWMt9BXN cU
has assertion: kin(p(MGI:Igf1r)) -> cat(p(MGI:Irs2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.946+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Igf1r)) -> cat(p(MGI:Irs2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19011156

6
value: We examined the effect of blockade of type 1 IGF tyrosine kinase receptor (IGF-IR) in a murine model of bleomycin-induced lung injury and fibrosis. Mice were treated with a monoclonal antibody against the IGF-I receptor (A12) or vehicle after intratracheal bleomycin instillation. MEASUREMENTS AND MAIN RESULTS: Mice treated with A12 antibody had significantly improved survival after bleomycin injury compared with control mice. Both groups of mice had a similar degree of fibrosis on days 7 and 14, but by Day 28 the A12-treated group had significantly less fibrosis. Delayed treatment with A12 also resulted in decreased fibrosis. A12-treated mice had significantly decreased apoptotic cells on Day 28 compared with control mice. We confirmed that A12 treatment induced mouse lung fibroblast apoptosis in vitro. In addition, IGF-I increased lung fibroblast migration. The primary pathway activated by IGF-I in lung fibroblasts was the insulin receptor substrate-2/phosphatidylinositol 3-kinase/Akt axis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19011156

RAVT5BDcPNbJk1ESXJ6DDyAVqQ67Ml5DO9gHk8TMO1MAU
has assertion: kin(p(PFH:"AKT Family")) => p(HGNC:TBC1D4,pmod(P,T,642))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.949+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"AKT Family")) => p(HGNC:TBC1D4,pmod(P,T,642))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19013499

5
value: In contrast, phosphorylation of AKT substrate 160kDa (AS160) at T642, which is essential for 14-3-3 recruitment and GLUT4 translocation, was reduced by 50% in basal and insulin-stimulated cells and this was mirrored by decreased 14-3-3 association.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19013499

RAbkXXUS1IVEhVRnb0cfbW3JrC02dRvEbKGDTBiZw2aGM
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Bcl2l1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.955+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Bcl2l1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAbmQQv91ClfZ3rAAv3PfRoQupfqCNtURseuDxdh0t4l8
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Bmp2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.957+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Bmp2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAUTxa2r3AFPbXDkZcPfJI4k5hsLtxd1A-mV v431VX1U
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Cald1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.960+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Cald1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAeXGe-Sn3Jxf9mBmsy-ZTMUlDOIlcncYvd 07-8sqJDA
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Ccnd2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.965+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Ccnd2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAToyvBqpyhfQyiidYX7QVs x TbNv9dwhTRkPZt2 XP8
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Cnn2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.975+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Cnn2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RASKqu2UnTFHxAoqUcB3XYTwXeqUosbHchguGr-2tIiU8
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Ddx3y)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.980+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Ddx3y)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAXk106xVks3fIUVOEOXfYG6yhGseyF3mcty252DyIASU
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Kif22)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.985+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Kif22)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAbBWD SGSe0o8 2usyo7fcwKDn-lUFm5GOh8djT8d3mc
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Ppp2r2a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:53.994+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Ppp2r2a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAWpxwk5iJ4CFAEPZI0KEIlGCX8YTfNTof2kHJn5hBtvw
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Thbs4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.053+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Thbs4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAQWcnPPWq4aRnqfhNL8kxiwgqN BwNHNNlHLuIpZGeew
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Tpx2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.056+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Tpx2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAc-O30wYzOuQ-8rzhiYhE0OEMuRT382k8n2vp JHdCaU
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Tro)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.057+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Tro)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RARHqm4DqcLVyknz5nYslk2CwnJb9e7Zhgyj-2BEw3GwU
has assertion: m(MGI:"Mir133a-1") -| r(MGI:Tnni1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.062+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-1") -| r(MGI:Tnni1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAeyVq6drpzvivQmoWQ38qva4ocx-bFgFms9ZmArz2puU
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Acta2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.067+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Acta2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RASgMpXXoLOAaBIvxfmZ GKY9XPdQfEyQd8xIjHhRK7wU
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Bcl2l2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.076+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Bcl2l2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAcQqPhfSxlKNLsRP9R4qo08YDmQ7eCPQxQpfLopkms5k
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Bmp2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.079+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Bmp2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAazOiGbmDvbrkjsORKvdWhiTIsbgD9JV23nw1Qqzc-xU
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Ccnd1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.090+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Ccnd1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RASpH9OVid0LdWsoL3l6TSe0xpYf9pYxEQPYrbqWjn8T8
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Cnn1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.095+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Cnn1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAeIHucGiSld95VEDHVPfvzg9iU0YExk-YeyLJMq YNjo
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Cdc20)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.098+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Cdc20)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAY-RLp74EFtJ2YL2KRuW2wTnDH8Phel6vh4ZShGpI3Js
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Cnn2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.103+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Cnn2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAdXOrfAaNoEh87NWvzvOfesom3oHmjL-7VVNaGxRy-7M
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Cnn3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.104+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Cnn3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAeZwV5YdO0dJOv-o miOo8qOsZKEh8AVC8Ox8SXNwAtE
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Csrp2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.105+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Csrp2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAdhydqU3OEJABI9G4j5tbDjbGNwFEIdzGzI8VweLfn1g
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Itga5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.112+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Itga5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAW5gT0He3NBNJ9vXMzky7j1Whhce3pJy9uscg-2170UY
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Kif22)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.113+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Kif22)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAQ t3u8Z3NxvvcFJDOmV1z6RgaNY8xxZjaOnFjNnVbZw
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Pfn2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.121+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Pfn2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RARAhdLKqUV8m88hFRawEOgty4OvSKYxl4X8TvWIvHuxk
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Pdlim5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.125+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Pdlim5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAdSj9H0xwpu4CaxzyYkYfwFq71NaFty22fgbMI0eD1sc
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Sdc4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.130+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Sdc4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAVsTjii6K9yPG CL1RB8dQCA4ISxMVWy1gjnC85DXuJA
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Thbs4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.134+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Thbs4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAQFaulZvd67 wtNpWuzH4bpWMMucKn5esQ6iVhsrJ7sU
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Tpm1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.135+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Tpm1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAbb2plicgkveWUhPdDPY0In2AICLecICXxO-wjhA92rM
has assertion: m(MGI:"Mir133a-2") -| r(MGI:Tpm2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.145+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(MGI:"Mir133a-2") -| r(MGI:Tpm2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19015276

4
value: Supplemental Table 2. Up-regulated genes in miR-133a dKO mutant hearts at P1. (Since single KO of miRNA133a have no phenotype, we assumed that miRNA133a-1 and miRNA133a-2 have redundant function)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19015276

RAXWEZtRuquiK2NaGvA57F9HxUI0dn11 wtP9JWUNx7bk
has assertion: p(HGNC:IL1B) -> p(HGNC:ZEB1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.149+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL1B) -> p(HGNC:ZEB1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19017734

4
value: IL-1b and PGE2 have the capacity to decrease E-cadherin expression and promote EMT. These inflammatory mediators have the capacity to up-regulate the zinc-finger E-box?binding transcriptional repressors of E-cadherin, including Zeb1, Snail, and Slug, thus leading to EMT progression (15, 52).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19017734

RAbk2JHEghOQU4tGmy44MIKxHAvv9JaBFaKHBe5aSPX3c
has assertion: kin(p(PFH:"PRKC Family")) -| tscript(p(HGNC:TCF4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.155+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -| tscript(p(HGNC:TCF4))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19018094

6
value: In addition, enzastaurininduced b-catenin coimmunoprecipitated with its cofactor T-cell factor 4 (Figure S1B), subsequently activating the T-cell factor 4 promoter in MM.1S, HEK293, and HeLa cell lines, as shown by the TOP-FLASH reporter assay (Figure S1C). Taken together, these results demonstrate that enzastaurin triggers accumulation of transcriptionally active b- catenin because of inhibition of its degradation, rather than induced overexpression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19018094

RAe3f6eWX3-x-2FyMsfw0eBupZDNm900kMQNS6lG0jSHE
has assertion: kin(p(PFH:"PRKC Family")) -| tscript(complex(p(HGNC:CTNNB1),p(HGNC:TCF4)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.158+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -| tscript(complex(p(HGNC:CTNNB1),p(HGNC:TCF4)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19018094

8
value: In addition, enzastaurininduced b-catenin coimmunoprecipitated with its cofactor T-cell factor 4 (Figure S1B), subsequently activating the T-cell factor 4 promoter in MM.1S, HEK293, and HeLa cell lines, as shown by the TOP-FLASH reporter assay (Figure S1C). Taken together, these results demonstrate that enzastaurin triggers accumulation of transcriptionally active b- catenin because of inhibition of its degradation, rather than induced overexpression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19018094

RAbD7HUMHuQ7iAsQC6zMQ2tLrVFVhItEY4vwmvZBLNmeY
has assertion: a(SCHEM:Tretinoin) -| cat(p(HGNC:MPO))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.169+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Tretinoin) -| cat(p(HGNC:MPO))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19026740

4
value: MPO activity was measured in the supernatant of PMA-activated neutrophils of six healthy nonsmoking human donors (two females, four males, ages 25-50 years). Vit A and RA effectively inhibited MPO activity by 31 and 21%, respectively (Fig. 3).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19026740

RAUTiVPRkx8HOST1PlrMKaI-6U92EJaNf8rQsKtGrIcCs
has assertion: tscript(p(MGI:Nfe2l2)) -> p(MGI:Srxn1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.176+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Nfe2l2)) -> p(MGI:Srxn1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19027064

5
value: Western blot analysis of lung proteins showed that Srx1 proteinwas present constitutively, and its level increased significantly on exposure to CS in Nrf2+/+ mice. By contrast, expression of Srx1 protein was low in Nrf2?/? mice and did not change significantly with CS exposure (Figs. 1B and C).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19027064

RAaTIpXLzHujiHzQnVf- zAT6R4hyMNFSglg2HYQNm0h4
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> kin(p(PFH:"AKT Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.185+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> kin(p(PFH:"AKT Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19038971

5
value: The PI3K/Akt pathway is involved in prototypical endothelial functions such as the regulation of vascular tone, angiogenesis, control of adhesion, and recruitment of leucocytes to the vessel wall (Figure 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19038971

RAfMN5DfYTZiUl5yINf3-W5guDaDb987LiuNV1syiamCM
has assertion: a(CHEBI:"hyaluronic acid") -> tscript(p(HGNC:RELA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.194+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hyaluronic acid") -> tscript(p(HGNC:RELA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19047049

4
value: Further analyses indicate that activation of SIRT1 (deacetylase) by resveratrol (a natural antioxidant) induces SIRT1-p300 association and acetyltransferase inactivation, leading to deacetylation of HA/CD44-induced beta-catenin and NFkappaB-p65, inhibition of beta-catenin-T-cell factor/lymphocyte enhancer factor and NFkappaB-specific transcriptional activation, and the impairment of MDR1 and Bcl-x(L) gene expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19047049

RAS5ZsqA-Uj29S0OXjm FD7l3XCUv1ewbDW-dddYsqk9c
has assertion: tscript(p(MGI:Nfatc3)) -> bp(MESHPP:"Liver Regeneration")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.205+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Nfatc3)) -> bp(MESHPP:"Liver Regeneration")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19059606

4
value: Hepatocyte proliferation and thus liver regeneration following hepatectomy was suppressed in NFAT4 knockout (KO) mice.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19059606

RARva1tb5I-m8wbsyY0oy9IiGn9zcXkp5vmup1P3ja74k
has assertion: p(MGI:Kras,sub(G,12,V)) -> a(CHEBI:glutathione)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.215+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: G,12,V
variant of: MGI:96680
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(MGI:Kras,sub(G,12,V)) -> a(CHEBI:glutathione)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

3
value: Indeed, significantly elevated GSH levels of 85 +/- 10 and 122 +/- 34 nmoles/mg protein were found in the K-Ras mutants G12V and G13D, whereas in the parental NIH3T3 cells and in the mock transfectants the GSH levels did not exceed 25 +/- 6 and 29 +/- 6 nmoles/mg protein, respectively. It is noteworthy that the Wt K-ras transfectants also exhibited a considerable increase of the intracellular GSH concentration to 62 +/- 5 nmoles/mg protein (Fig. 4).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RActYh5fQbk aRTUv3uh8XymLqsXrVbfrw2JL7TCMOUBE
has assertion: p(MGI:Kras) -> p(MGI:Hnrnpd)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.218+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Kras) -> p(MGI:Hnrnpd)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

4
value: NIH3T3 cells transformed by different mutants of Kras (WT, G12V and G13D) and differentially expressed proteins in the pH range 6 to 11 and identified by mass spec. Fold change >1.3 and p-value < 0.05.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RARVaOXc-B8HVpRgFdW8PRaFtsyxz0dgfoo2-j93umKbM
has assertion: p(MGI:Kras) -> p(MGI:Psmc6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.219+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Kras) -> p(MGI:Psmc6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

4
value: NIH3T3 cells transformed by different mutants of Kras (WT, G12V and G13D) and differentially expressed proteins in the pH range 6 to 11 and identified by mass spec. Fold change >1.3 and p-value < 0.05.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RATcnbUpWZaXa3GEXqEKZ6RfUJFElR0h--H0gxWgZiR0Y
has assertion: p(MGI:Kras,sub(G,12,V)) -| p(MGI:Etfb)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.221+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: G,12,V
variant of: MGI:96680
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(MGI:Kras,sub(G,12,V)) -| p(MGI:Etfb)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

4
value: NIH3T3 cells transformed by different mutants of Kras (WT, G12V and G13D) and differentially expressed proteins in the pH range 6 to 11 and identified by mass spec. Fold change >1.3 and p-value < 0.05.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RASP1eqEN3OZ1xAB-AWMshaTzyvFHpNL1o1HIAsqAj0wQ
has assertion: p(MGI:Kras,sub(G,13,D)) -| p(MGI:Serpinh1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.233+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: G,13,D
variant of: MGI:96680
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(MGI:Kras,sub(G,13,D)) -| p(MGI:Serpinh1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

4
value: NIH3T3 cells transformed by different mutants of Kras (WT, G12V and G13D) and differentially expressed proteins in the pH range 6 to 11 and identified by mass spec. Fold change >1.3 and p-value < 0.05.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RASEWA2c AzHzaYKvCSPNdCtckLYwSylZJvNOSqP-Vn4Y
has assertion: p(MGI:Kras,sub(G,13,D)) -| p(MGI:Snrpb)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.234+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: G,13,D
variant of: MGI:96680
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(MGI:Kras,sub(G,13,D)) -| p(MGI:Snrpb)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

4
value: NIH3T3 cells transformed by different mutants of Kras (WT, G12V and G13D) and differentially expressed proteins in the pH range 6 to 11 and identified by mass spec. Fold change >1.3 and p-value < 0.05.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RAfrD5do1h9j3kGPd6qGBJ4buGN3u 1Ua-CDu7pg0yHV8
has assertion: a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.237+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

2
value: The H2O2-mediated cell death was confirmed by an at least 6-fold increased cytotoxicity in NIH3T3 cells and mock controls compared with the less pronounced toxic effect on the oncogenic K-ras–expressing cell lines G12V and G13D (2- to 3-fold; Fig. 5B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RAbX36d6BwWt JaBBuWxD0mDg9bg5ugiKhdsWQ Rzft A
has assertion: a(CHEBI:"hydrogen peroxide") -> cat(p(MGI:Casp3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.242+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> cat(p(MGI:Casp3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

4
value: cells were left untreated or treated with H202 and formaldehyde followed by incubation with the profluorescent Z-DEVD-rhodamine 110 substrate. The catalytic activity of the two effectors, caspase-3 and caspase-7, was determined by measuring the fluorescence of the cleavage product. In the presence of 100 Amol/L H2O2, the caspase-3/7 activity was 8- to 11-fold elevated in parental, mock, and Wt K-ras–transfected cells in comparison with the untreated cells, whereas the enzymatic activity was only 2- to 3-fold enhanced in the two K-ras mutants (Fig. 5D). It is noteworthy that an altered caspase activity in cells treated with formaldehyde was not observed (data not shown).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RAfmGbQLAcc93TIcMgftY47npuYrM68WKdsZAJMs6YQwE
has assertion: a(CHEBI:"hydrogen peroxide") -> cat(p(MGI:Casp7))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.244+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> cat(p(MGI:Casp7))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19074874

4
value: cells were left untreated or treated with H202 and formaldehyde followed by incubation with the profluorescent Z-DEVD-rhodamine 110 substrate. The catalytic activity of the two effectors, caspase-3 and caspase-7, was determined by measuring the fluorescence of the cleavage product. In the presence of 100 Amol/L H2O2, the caspase-3/7 activity was 8- to 11-fold elevated in parental, mock, and Wt K-ras–transfected cells in comparison with the untreated cells, whereas the enzymatic activity was only 2- to 3-fold enhanced in the two K-ras mutants (Fig. 5D). It is noteworthy that an altered caspase activity in cells treated with formaldehyde was not observed (data not shown).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19074874

RAUKgJ6tGre7VAlAEVNGy4m1KhP0b2boez6dqG3kQFcQA
has assertion: m(HGNC:MIR106B) -| p(HGNC:APP)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.256+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR106B) -| p(HGNC:APP)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19110058

4
value: We show that miRNAs belonging to the miR-20a family (that is, miR-20a, miR-17-5p and miR-106b) could regulate APP expression in vitro and at the endogenous level in neuronal cell lines. ......Of note, APP mRNA expression was not affected by miR-20a overexpression (Fig. 2C), indicating that this miRNA blocks protein translation and does not induce (direct) degradation of the target mRNA.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19110058

RAXhednP1p7vJlNZIjRKt4uyWmLLkPx IVLoLGDoFUgjg
has assertion: m(HGNC:MIR17) -| p(HGNC:APP)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.259+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR17) -| p(HGNC:APP)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19110058

4
value: We show that miRNAs belonging to the miR-20a family (that is, miR-20a, miR-17-5p and miR-106b) could regulate APP expression in vitro and at the endogenous level in neuronal cell lines. ......Of note, APP mRNA expression was not affected by miR-20a overexpression (Fig. 2C), indicating that this miRNA blocks protein translation and does not induce (direct) degradation of the target mRNA.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19110058

RAbASRjvUDl4zgXa5YVHkofulU-5qxtd8WDC08RyfgA0o
has assertion: a(CHEBI:estradiol) -> (a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:TFF1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.262+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:estradiol) -> (a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:TFF1))
label: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:TFF1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1911215

4
value: Bryostatin alone also inhibited growth The effect of TPA on MCF-7 cells was partially reversed by bryostatin TPA alone increased pNR2 and pNR100 levels in MCF-7 cells and the combined effect of oestradiol and TPA had a marked synergistic effect in increasing the transcript levels of these genes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1911215

RAV-fOZHt2aZKy2yb1sQqelAhdNa eTuaZKlmp-HwxFjY
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -| bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.277+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -| bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1911215

2
value: The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) (10 nM) produce a marked reduction in the growth, measured by thymidine uptake, of MCF-7 cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1911215

RAQKQlQRLZ7WdF-FEalEY4fC0rz8qCbkL1svT7xrDfBqU
has assertion: p(HGNC:TNF) -> p(HGNC:VEGFA)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.279+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> p(HGNC:VEGFA)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19115032

4
value: Proinflammatory cytokines (IL-1b, IL-6, and TNF-alpha) increased VEGF and MMP-9 in corneal cells and macrophages.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19115032

RAbEE2Kws6tBXiQuFICICWo8gggqJXW9Yeremuip-H-Mc
has assertion: a(SCHEM:Estrogens) -| r(HGNC:MTA3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.280+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Estrogens) -| r(HGNC:MTA3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19116762

3
value: Another member of this family, MTA3, is induced by estrogen and represses the expression of the transcriptional repressor Snail, a master regulator of \"epithelial to mesenchymal transitions\", resulting in the expression of the cell adhesion molecule E-cadherin and maintenance of a differentiated, normal epithelial phenotype in breast cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19116762

RAVpRPka6UJwrtaaIroMMh7mvQk r5R8udVJsRrKkR8mc
has assertion: p(HGNC:TP53,pmod(P,S,46)) => tscript(p(HGNC:TP53))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.282+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TP53,pmod(P,S,46)) => tscript(p(HGNC:TP53))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19118006

5
value: Mutation of p53 Ser(58) (equivalent to human p53 Ser(46)) abrogates transcription of these genes
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19118006

RAS1eLnlwQX6aMWU74FOj474UtNvPgJq5YXzbq7xrZw1Y
has assertion: p(HGNC:NUDT1) -| p(HGNC:TP53)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.288+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NUDT1) -| p(HGNC:TP53)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19118192

4
value: We also found that BJ cells entering senescence after shMTH1 knockdown up-regulated the levels of the p53, p21Cip1/Waf1 and p16INK4a tumor suppressor proteins
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19118192

RAX22V92Z33l3Qp2d5cFqya3hBOz7wAU0SAvGH7fYTvfI
has assertion: cat(p(HGNC:HDAC3)) -| p(HGNC:STAT3,pmod(P,S,727))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.291+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:HDAC3)) -| p(HGNC:STAT3,pmod(P,S,727))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19121623

5
value: Here, we show that treatment of HeLa cells with a histone deacetylase (HDAC) inhibitor, trichostatin A, or small-interfering RNA (siRNA)-mediated repression of HDAC3, enhances phosphorylation of STAT3 at Ser727.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19121623

RATzqDKIcJCnX5fxFVbXmTPXjo0S0Ju87X1x7ZxwcVzug
has assertion: kin(p(HGNC:GSK3B)) => p(HGNC:SREBF1,pmod(P,T,426))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.293+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:GSK3B)) => p(HGNC:SREBF1,pmod(P,T,426))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126544

5
value: Glycogen synthase kinase-3 phosphorylates Ser-434, and the phosphorylation of this residue is attenuated in response to insulin signaling. Interestingly, phosphorylation of Ser-434 promotes the glycogen synthase kinase-3-dependent phosphorylation of Thr-426 and Ser-430 and destabilizes SREBP1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126544

RAfVVGQjEieypcDJ7cGf0gpU0imwCVifFpVvafBlJJmZg
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:AKR1B10)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.297+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:AKR1B10)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAWc93SHb8nBaYq70VGoT0kfQNG9Vhtkqi6HnO77QagOU
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:AVEN)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.302+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:AVEN)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAc5IQH9OG6nkfo2Ptys0hkCIkVdmPc2A-dVCjmOh10co
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:COL3A1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.317+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:COL3A1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAUcwX5TuZ84evH7JdbxQ3p4KpqP0E9NDM9sWG0Nhbtyw
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:DICER1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.320+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:DICER1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAYxUDKMOn1dES3SYrImJCM-yvJVDu7-ZVrlGot8dTy g
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:ECE2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.321+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:ECE2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAaptg-pT1RNlv1jhjvBi UtHn4Ss-LNzDPpc2nuObnho
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:EIF4EBP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.324+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:EIF4EBP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RARvFKxCi6F1zvbfjy0oAGYvz0czUntgXhjwDLEPXwehw
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:ELF4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.325+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:ELF4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAbxL0XeVCPu2TMvxyepwpNH8uk5EYnWQd8uY9y5mYKo8
has assertion: m(HGNC:MIRLET7B) -| r(EGID:8226)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.334+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(EGID:8226)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAYFGwrf fTN6WxzOQd7pLBhc3447Rk3R2W 6kAFofwk8
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:LEPROTL1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.342+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:LEPROTL1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAXCq2BhtHBNb5Q6qnV3Z7gWA84FwEdLDi5 TlWmE0BHY
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:MMP11)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.349+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:MMP11)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RASI-HTGmKhkXXId3Vw-d7E0nKKWWQIu7lTFKEkYZI40I
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:ORM1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.356+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:ORM1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAUwjYhMsn2Jj4tWmABASZZRFzVqbQc9KHYYuU3f9fnIU
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:PLAGL2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.357+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:PLAGL2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RARioBXyqAEUyaQPdKQm7OgttUVGbzP2irFPN2d7pO52g
has assertion: m(HGNC:MIRLET7B) -| r(EGID:11020)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.363+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(EGID:11020)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RATggRGB6FwbO9wJLR7PJC bvBKW7bmADRzna6d-SyPUE
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:SULF1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.374+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:SULF1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAeFXtIVD-yLIPhiDnWHv8bJLAVwI1MLUUtfhiLKxy5KY
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:SULF2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.380+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:SULF2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RAV4UDNuiGFXnb2mnr7sdckFMrEWA6zZGfcfLQSqZwhh4
has assertion: m(HGNC:MIRLET7B) -| r(HGNC:TRAM2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.384+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIRLET7B) -| r(HGNC:TRAM2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19126550

4
value: Combining microarray techniques with DNA sequence analysis to identify potential let-7 targets, we discovered 838 genes with a let-7 binding site in their 3'UTR, that were down-regulated upon overexpression of let-7b. (From Suppl Table 1). To identify potential let-7 targets, we looked for genes consistently down-regulated in the presence of let-7 (i.e., genes within cluster 2 or 4) that also contain at least one let-7 recognition site within their 3’ UTR, resulting in 838 genes (Supplementary Table 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19126550

RATIp2Luv8ax03QtNM7f1yLSKIVPkPXst7owj9KDV6C2s
has assertion: a(CHEBI:atorvastatin) -> p(MGI:Prkaa1,pmod(P,T,183))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.396+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:atorvastatin) -> p(MGI:Prkaa1,pmod(P,T,183))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19131647

3
value: Shear stress, atorvastatin, and adiponectin all increased AMPK Thr172 (activating phosphorylation found at Thr183 on the Uniprot sequence Q5EG47) and eNOS Ser633 phosphorylations (Ser632 from sequence Uniprot P70313), which were abolished if AMPK was pharmacologically inhibited or genetically ablated. The constitutively active form of AMPK or an AMPK agonist caused a sustained Ser633 phosphorylation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19131647

RAcwR-TnBsbKseGFQ7XgBAFNDMVON39jL6aVg6zWZb5JE
has assertion: p(HGNC:IL6) -> complex(p(HGNC:FER),p(HGNC:STAT3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.411+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL6) -> complex(p(HGNC:FER),p(HGNC:STAT3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19147545

6
value: Moreover, IL-6 triggered a rapid formation of Fer/gp130 and Fer/STAT3 complexes in a time-dependent manner and consistent with changes in Fer and STAT3 phosphorylation and cytoplasmic/nuclear distribution.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19147545

RAcMBJhgFw3TqkXrl3Pgn5t3zE3LKlmXkvlrgQO1o9ZHE
has assertion: p(HGNC:IL10) -| bp(GO:"platelet aggregation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.412+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL10) -| bp(GO:"platelet aggregation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19149643

3
value: NO and interleukin (IL)-10 suppresses adhesion and aggregation of blood platelets [96].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19149643

RARK5SaJE7i7CBJAHs4F0veqz-V9VMESMYN-pH233VTAQ
has assertion: cat(p(HGNC:PTGIR)) -| bp(GO:"platelet aggregation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.415+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:PTGIR)) -| bp(GO:"platelet aggregation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19149643

4
value: PGI2 acts on the PGI2 receptor (IP receptor) to inhibit platelet aggregation and smooth muscle relaxation [137].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19149643

RAVuCEHjV9vrEna1-ZvqAL25imZgOzFPad7PVxaBKsyds
has assertion: cat(p(HGNC:ACE)) -> path(MESHD:"Myocardial Infarction")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.417+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:ACE)) -> path(MESHD:"Myocardial Infarction")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19149643

4
value: The potential link between Ang II and atherosclerosis is strengthened by the Heart Outcomes Prevention Evaluation (HOPE) trial where ACE (angiotensin converting enzyme) inhibition reduced the rates of death, myocardial infarction, and stroke in patients with atherosclerosis [57].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19149643

RAWFxc90asdXiMwn2NmzRhHAm2Ukdzj0GU7Mw-erQQSPA
has assertion: a(SCHEM:"alpha-Cobratoxin") -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.422+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"alpha-Cobratoxin") -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19151195

2
value: In conclusion, the results of this study show that a-CbT, a powerful high-affinity a7-nAChR inhibitor, induces antitumor activity against NSCLC by triggering apoptosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19151195

RAZPiedIzVzC9TeVzVEFAcDj yBJlpO7y6IyYFv2RfMzw
has assertion: a(CHEBI:nicotine) -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.426+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:nicotine) -> bp(GO:"cell proliferation")
label: cat(p(HGNC:CHRNA7)) -> (a(CHEBI:nicotine) -> bp(GO:"cell proliferation"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19151195

5
value: Studies have shown that a7 is the main nAChR7 subunit that mediates the proliferative effects of nicotine in lung cancer cells (26–31).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19151195

RAUIcUhFotgpiovx0sH73QYjCFUYWg56vt6RMt1GzMquA
has assertion: m(HGNC:MIR106B) =| r(HGNC:CDKN1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.427+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR106B) =| r(HGNC:CDKN1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19153141

4
value: p21 is directly regulated by miR-106b through the 3'-UTR. The reporter containing the 3'-UTR of p21 (FL-p21) was transfected into HeLa cells along with miRNA duplexes
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19153141

Selventa

RAU DCeIqhZgjSqQ7xfgSxiMuQx9ZyuVjp06-9PfUakGI
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:CDKN1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.442+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:CDKN1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAdVkLicUJmbfpfZBMhMC9mqbM6TQyQ659rq6UDL2aDi0
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:F3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.456+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:F3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAa4l7XvljkPzIgFeW-NEHfwWKEgqByaPufIVXXECXH0M
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:FUS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.464+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:FUS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAVNMQAIg34wVaMSw P1nl25B7Vj2GZpAaEPDv6Zaps-Y
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:HIST1H2BD)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.470+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:HIST1H2BD)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAelY6mOXOr76MJAWrTt7NdsZaEOjsltvldpcR1G-7xhA
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:IFI6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.476+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:IFI6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAeqzKZ0fSlOTyhZV70OdTPJXBuIdWxSkN6A939dVnpI4
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:ITFG1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.477+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:ITFG1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RATiafzppUZD4dB5c34xtv9NvjEhl0zzvhgF7HXGTvxPI
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:MMP3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.490+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:MMP3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAcFVrFgXTQHtwF3rTki6CLVDic9e00Xb8Z3Bgff3EJ0E
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:MX1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.491+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:MX1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAWMSgPNWDbAwZdgatyC3JZoiNWV5hmr 1U3nEwzOORc4
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:MYBL1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.494+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:MYBL1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAbd4smDt n71mXNLanQfMf1HF6q8YOgm9TuLMMI6eqe8
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:OAS2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.552+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:OAS2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAWl5npTXCLKcPUZhnP3DVRBVOelJs7uIqubQOL tSzA4
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:ODC1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.553+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:ODC1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAc34og7uTgNjXjmpodnfwkcv4SV4BdqC5dcDgqtlCzwQ
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:PSG3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.557+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:PSG3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAaMWxF0knvhq03Sp4hvEmPgxSVNhMZbaHgLH7fUZ1qVA
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:PSG5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.558+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:PSG5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAZZNyLHJXhBB4j WgbT6aehcsFGV7yweWzqWpKlS107Y
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:PTP4A1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.562+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:PTP4A1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RATpKBIoghXFBuecizlcCbsJi0hQ69QPncZevSwY-L0 E
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:STAT1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.564+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:STAT1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAZehz1wW9EYgCwWIbqkf1reD2u0WGsocazQ9c2AlwVxY
has assertion: bp(GO:"replicative cell aging") -> r(HGNC:TAP2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.568+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -> r(HGNC:TAP2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19155301

3
value: from full text - Figure 2. Analysis of the senescence transriptome reveals significant overlap between cells undergoing RS and SIPS. A, microarray analysis of young BJ fibroblasts and BJ fibroblasts undergoing RS or bleomycin-induced SIPS. Hierarchical clustering of consistent transcript alterations across all conditions and replicas is plotted. B, Venn diagram plots genes that significantly overlap in fibroblasts undergoing RS and SIPS versus young. C, GO analysis of up-regulated classes in cells undergoing RS and SIPS compared with their younger counterparts (i.e., immune & inflammation, mitogens & regulation of proliferation, and extracellular matrix & secreted factors).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19155301

Selventa

RAWUJiqD6rv2y7GmHzdzePV2lNJawPDVfnHuCCfk9 0zU
has assertion: path(SDIS:"bacterial infection") -> a(CHEBI:lipopolysaccharide)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.579+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"bacterial infection") -> a(CHEBI:lipopolysaccharide)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1916089

2
value: The lipid A domain of lipopolysaccharide (LPS) is a unique, glucosamine-based phospholipid that makes up the outer monolayer of the outer membrane of most gram-negative bacteria.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1916089

Selventa

RAcLAGvQ5s8eQIBHZPXF7mbhAhvjympfvael07TcOi0xk
has assertion: a(CHEBI:lipopolysaccharide) -| p(MGI:Pparg)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.580+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -| p(MGI:Pparg)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19166963

3
value: As shownin Fig.2Aand B, LPS-inducedup-regulation of AEBP1 expression is accompanied by significant inhibition of PPAR1 and LXR expression where their levels drop by 5 and 3 folds, respectively, 24 h post LPS treatment.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19166963

Selventa

RAdHjlq3 zoKa0iP9gqq7 caw8QHVkGs1Hj4ZXUDaShII
has assertion: p(PFH:"PRKA Family") -> path(SDIS:"I(Cl,PKA) PKA-dependent chloride current")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.587+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFH:"PRKA Family") -> path(SDIS:"I(Cl,PKA) PKA-dependent chloride current")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19171656

3
value: At the molecular level, all cardiac Cl? channels described so far may fall into the following Cl? channel gene families: (1) the cystic fibrosis transmembrane conductance regulator (CFTR), which is a member of the adenosine triphosphate-binding cassette (ABC) transporter superfamily and may be responsible for the Cl? currents activated by protein kinase A (PKA) (I Cl,PKA), protein kinase C (PKC) (I Cl,PKC) , and extracellular ATP (I Cl,ATP) in the heart; (2) ClC-2, which is a member of the ClC voltage-gated Cl? channel superfamily and may be responsible for the hyperpolarization- and cell swelling-activated inwardly rectifying Cl? current (I Cl,ir) (Duan et al. 2000; Komukai C et al. 2002a,b); (3) ClC-3, which is also a member of the ClC voltage-gated Cl? channel superfamily and may be responsible for the volume-regulated outwardly rectifying Cl? current (I Cl,vol), including the basally activated (I Cl,b) and swelling activated (I Cl,swell) components; (4) CLCA-1, which was thought to be responsible for the Ca2+-activated Cl? current (I Cl,Ca); (5) Bestrophin, a candidate also for I Cl,Ca; and (6) TMEM16, a novel candidate for I Cl,Ca
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19171656

Selventa

RAa5Bk5iC5WVOADaU Fv3-c1G5ocMd6TDXMrLTVbg1E0
has assertion: p(PFH:"PRKC Family") -> path(SDIS:"I(Cl,PKC) PKC-dependent chloride current")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.588+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFH:"PRKC Family") -> path(SDIS:"I(Cl,PKC) PKC-dependent chloride current")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19171656

3
value: At the molecular level, all cardiac Cl? channels described so far may fall into the following Cl? channel gene families: (1) the cystic fibrosis transmembrane conductance regulator (CFTR), which is a member of the adenosine triphosphate-binding cassette (ABC) transporter superfamily and may be responsible for the Cl? currents activated by protein kinase A (PKA) (I Cl,PKA), protein kinase C (PKC) (I Cl,PKC) , and extracellular ATP (I Cl,ATP) in the heart; (2) ClC-2, which is a member of the ClC voltage-gated Cl? channel superfamily and may be responsible for the hyperpolarization- and cell swelling-activated inwardly rectifying Cl? current (I Cl,ir) (Duan et al. 2000; Komukai C et al. 2002a,b); (3) ClC-3, which is also a member of the ClC voltage-gated Cl? channel superfamily and may be responsible for the volume-regulated outwardly rectifying Cl? current (I Cl,vol), including the basally activated (I Cl,b) and swelling activated (I Cl,swell) components; (4) CLCA-1, which was thought to be responsible for the Ca2+-activated Cl? current (I Cl,Ca); (5) Bestrophin, a candidate also for I Cl,Ca; and (6) TMEM16, a novel candidate for I Cl,Ca
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19171656

Selventa

RAfExJ22Wp6bsbTCTgI0kFZsDz7 wnG0iZJ0xlXCMayNQ
has assertion: p(RGD:Tnf) -> kin(p(RGD:Ikbkb))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.589+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Tnf) -> kin(p(RGD:Ikbkb))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19179648

5
value: Similarly, TNF-alpha induced activation of IKKbeta, as seen by reduced IkappaBalpha levels, but pretreatment with LA protected the myotubes from the TNF-alpha -induced IKKbeta activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19179648

Selventa

RAdhEuJRR1QJgYvyGKTG1eClZ56axhTwehigqXAV3LV M
has assertion: bp(GO:"inflammatory response") -> path(MESHD:Sepsis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.594+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"inflammatory response") -> path(MESHD:Sepsis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19201901

2
value: Sepsis is a devastating condition characterized by a systemic inflammatory response. Recently, high mobility group box 1 (HMGB1) was identified as a necessary and sufficient mediator of the lethal systemic inflammation caused by sepsis...In this study, we demonstrate that the IFN-beta-mediated JAK/STAT pathway is essential for LPS or Escherichia coli-induced HMGB1 release, which is dependent on Toll/IL-1R domain-containing adapter-inducing IFN-beta adaptor.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19201901

Selventa

RARvyMwBM9JWtGpQhHvK7HMfF2gWRBYhCgjVgxiia4s20
has assertion: a(CHEBI:lipopolysaccharide) -> r(MGI:Mmp9)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.595+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(MGI:Mmp9)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19208854

3
value: Consistently, BBR inhibited LPS-induced expression of proinflammatory genes including IL-1beta, IL-6, iNOS, MCP-1, COX-2, and matrix metalloprotease-9 in peritoneal macrophages and RAW 264.7 cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19208854

Selventa

RARLkejlzyVBEyfM2rRozoSMc63bp-95XWZiMMV kZWxs
has assertion: kin(complex(NCR:"AMP Activated Protein Kinase Complex")) -| cat(p(RGD:Lipe))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.596+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCR:"AMP Activated Protein Kinase Complex")) -| cat(p(RGD:Lipe))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19214174

5
value: n summary, despite different fat depots eliciting distinct rates of lipolysis, acute AICAR-induced AMPK activation suppressed HSL phosphorylation/activation and exerted similar antilipolytic effects on both VC and SC adipocytes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19214174

Selventa

RARxFjmv-a3N-9UcoPOI524C9p Rg-zk3o KI-r3AmZfo
has assertion: bp(MESHPP:Obesity) negativeCorrelation r(MGI:Car3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.605+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(MESHPP:Obesity) negativeCorrelation r(MGI:Car3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1922100

3
value: Quantitative comparisons of CA III protein and mRNA levels indicate that this enzyme is expressed at lower levels in adipose tissue from animals that were either genetically obese or had experimentally induced obesity compared to levels in the corresponding lean controls. This decrease in CA III expression was unique to adipose tissue
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1922100

Selventa

RAYLbgDJo53MmUYWir6-gxFKncu82Ds9mAsWPqWiC3ZHs
has assertion: p(HGNC:KRAS) -> p(HGNC:CDKN1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.609+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:KRAS) -> p(HGNC:CDKN1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19223555

4
value: A549 cells harbor the K-ras mutation. Active Ras can induce p21Cip1/Waf1 expression and cell cycle arrest via the p14Arf-p53 pathway, which is defective in A549 cells (Supplementary Fig. S1A) and via mitogen-activated protein kinase (MAPK) signaling (43).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19223555

Selventa

RAcMxw58f5U9UjV6lTxdhofiXw96zowdxSBhgZb1IhVDo
has assertion: p(HGNC:RASSF1) -> kin(p(PFH:"MAPK Erk1/3 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.613+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:RASSF1) -> kin(p(PFH:"MAPK Erk1/3 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19223555

5
value: After stimulation with the mitogen phorbol 12-myristate 13- acetate (PMA) or serum, conditionally expressed RASSF1A specifically enhanced the activating phosphorylation of ERK, but not of p38 kinase or c-Jun NH2 kinase (Fig. 5A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19223555

Selventa

RAbFhgrgwQyjAt0ZMWJC7eelZ0sYpXaim4h1NzGHfI38w
has assertion: a(SCHEM:"HPV-16") -| (p(HGNC:RASSF1) -> path(SDIS:"Oncogene induced senescence"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.620+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"HPV-16") -| (p(HGNC:RASSF1) -> path(SDIS:"Oncogene induced senescence"))
label: p(HGNC:RASSF1) -> path(SDIS:"Oncogene induced senescence")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19223555

4
value: RASSF1A-induced senescence was prevented by coexpression of HPV E7 oncogene (Fig. 4B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19223555

Selventa

RAVZJNUBfP5Kp05wi4fsI4yu8ycP4aEMcES15YD-MOres
has assertion: p(PFH:"AKT Family") => p(HGNC:RAF1,pmod(P,S,259))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.622+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFH:"AKT Family") => p(HGNC:RAF1,pmod(P,S,259))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19223555

4
value: Raf itself is negatively regulated by phosphorylation at Ser259 through Akt, an important effector of phosphoinositide 3-kinase (PI3K) signaling (30, 44).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19223555

Selventa

RAWeVToePAv85guia81IY4ABAnaEBOODiPIRsEszoD9EU
has assertion: p(HGNC:CDKN2A) -> path(SDIS:"Oncogene induced senescence")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.627+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CDKN2A) -> path(SDIS:"Oncogene induced senescence")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19223555

3
value: The CDK inhibitor p16Ink4a is another p53-independent regulator of oncogene-induced cell cycle arrest and senescence (5, 13).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19223555

Selventa

RAWrWxpvi6l5f-oqO4oNR3Z1IXeMPekPC6nISuJGdXz7M
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> bp(GO:"cell migration")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.632+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> bp(GO:"cell migration")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19233848

3
value: Stimulation with those CCR6 ligands leads to calcium mobilization and elevated active RhoA, phosphorylated myosin light chain, and F-actin accumulation. HBD2 and CCL20 were unable to stimulate migration in the presence of either Rho-kinase or phosphoinositide 3-kinase inhibitors or an intracellular calcium chelator.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19233848

Selventa

RAX40nu5Ulnx544PHZvKkxtf4w2q8km4w8wvPqfXN-KSg
has assertion: p(HGNC:HGF) => kin(p(HGNC:MET))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.633+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:HGF) => kin(p(HGNC:MET))
label: p(HGNC:IL32) -| (p(HGNC:HGF) => kin(p(HGNC:MET)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19234748

7
value: NK4, a competitive antagonist for HGF and the c-Met receptor, prevents tumor cell growth and metastasis via its bifunctional properties to act as an HGF antagonist and angiogenesis inhibitor.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19234748

Selventa

RAe4pCQ WgTKq4NFec4NTRJrO4I4R Bj0EeENOHN3HqIQ
has assertion: p(MGI:Tgfa) => kin(p(MGI:Egfr))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.635+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Tgfa) => kin(p(MGI:Egfr))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19244201

5
value: Transforming growth factor (TGF)-alpha is a ligand for the epidermal growth factor receptor (EGFR).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19244201

Selventa

RAYZeoJm4Wevpe3rRl DW9Ce0T 4uqOmliyBAeP5FQIdU
has assertion: m(HGNC:MIR21) -| p(HGNC:H1FX)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.655+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR21) -| p(HGNC:H1FX)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19253296

4
value: By knocking down the expression of endogenous miR-21 in MCF-7 breast cancer cells, we observed an increase in the abundance of 58 proteins, implying that they could be potential targets of miR-21. Validation of 12 of these candidate targets in luciferase assays showed that 6 of them were likely direct targets of miR-21. Importantly, the mRNA of the majority of the candidate targets tested did not show a concomitant increase in abundance.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19253296

Selventa

RAW-0wwR5mdExd-t4h3EVO-uS86BTKbCMA3qdHxfOWlm0
has assertion: m(HGNC:MIR21) -| p(HGNC:SEC23A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.675+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR21) -| p(HGNC:SEC23A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19253296

4
value: By knocking down the expression of endogenous miR-21 in MCF-7 breast cancer cells, we observed an increase in the abundance of 58 proteins, implying that they could be potential targets of miR-21. Validation of 12 of these candidate targets in luciferase assays showed that 6 of them were likely direct targets of miR-21. Importantly, the mRNA of the majority of the candidate targets tested did not show a concomitant increase in abundance.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19253296

Selventa

RAUWm PhAvMr8jJnZ1xd-156KcxooElyknt1UAPeiipok
has assertion: m(HGNC:MIR21) -| p(HGNC:STARD10)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.677+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR21) -| p(HGNC:STARD10)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19253296

4
value: By knocking down the expression of endogenous miR-21 in MCF-7 breast cancer cells, we observed an increase in the abundance of 58 proteins, implying that they could be potential targets of miR-21. Validation of 12 of these candidate targets in luciferase assays showed that 6 of them were likely direct targets of miR-21. Importantly, the mRNA of the majority of the candidate targets tested did not show a concomitant increase in abundance.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19253296

Selventa

RAQkPyDSq zucjgFHghOzHIEhPrAVXufojAgi7XBDiwDs
has assertion: cat(p(HGNC:F2R)) -> p(HGNC:PDE3A,pmod(P,S,312))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.692+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:F2R)) -> p(HGNC:PDE3A,pmod(P,S,312))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19261611

5
value: Stimulation of platelets with the PAR-1 agonist SFLLRN resulted in rapid and transient phosphorylation of PDE3A on Ser(312), Ser(428), Ser(438), Ser(465), and Ser(492). Furthermore, phosphorylation and activation of PDE3A required the activation of PKC, but not of PI3K/PKB, mTOR/p70S6K, or ERK/RSK. Activation of PKC by phorbol esters also resulted in phosphorylation of the same PDE3A sites in a PKC-dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19261611

Selventa

RAatYHfWQx1mqX4fujfgD3GDBjqPXI1uOEczccIHtY r4
has assertion: kin(p(PFH:"PRKC Family")) -> p(HGNC:PDE3A,pmod(P,S,312))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.697+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> p(HGNC:PDE3A,pmod(P,S,312))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19261611

5
value: Stimulation of platelets with the PAR-1 agonist SFLLRN resulted in rapid and transient phosphorylation of PDE3A on Ser(312), Ser(428), Ser(438), Ser(465), and Ser(492). Furthermore, phosphorylation and activation of PDE3A required the activation of PKC, but not of PI3K/PKB, mTOR/p70S6K, or ERK/RSK. Activation of PKC by phorbol esters also resulted in phosphorylation of the same PDE3A sites in a PKC-dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19261611

Selventa

RAQYwKjT6TvEERq0Rc1CBbfwXMG6Pdu8hVS8Ezo9veFvg
has assertion: cat(p(HGNC:CASP1)) -> p(HGNC:IL1B)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.699+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CASP1)) -> p(HGNC:IL1B)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19262504

5
value: Activation of the inflammasome is responsible for the generation of active caspase-1, which cleaves a number of pro-inflammatory cytokines into their bio-active form, including IL-1B , IL-18, and IL-33.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19262504

Selventa

RAclAC6fZbF2DO4U6dEjsOiG32arAJQZdBg9ANCWYbMMQ
has assertion: bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.703+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19265129

3
value: As depicted in Fig. 1A, Western blot analysis shows a HIF-1a induction upon culture of IGR-Heu under hypoxic conditions.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19265129

Selventa

RAcM7qo-aWQc5xfWFJAIayjE3rxHGFGDaKgPcgh8lo2Yw
has assertion: tscript(complex(NCM:"Nfkb Complex")) => r(MGI:Cebpd)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.708+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCM:"Nfkb Complex")) => r(MGI:Cebpd)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19270711

4
value: Pharmacological inhibition of NF-kappaB blocked LPS-induced Cebpd transcription (Fig. 1d), and LPS-induced Cebpd mRNA (Fig. 1d) and protein (Fig. 1e) quantities were substantially increased in Atf3-null macrophages. Taken together, these data demonstrate that LPS-induced transcription of Cebpd is absolutely dependent on NFkappaB, and that NFkappaB-dependent Cebpd mRNA production is attenuated by ATF3. ChIP analysis demonstrated rapid and transient recruitment of Rel to the promoter of the Cebpd gene; maximal binding was seen 1 hr after stimulation with LPS (Fig. 1f). By contrast, LPS-stimulated ATF3 binding to the promoter of the Cebpd gene (over basal amounts) occurred after 3 h and was sustained (Fig. 1f).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19270711

Selventa

RAc6p1hFRVSXafkhWxTzTRA363xYjssx52SZxzZUwA0QU
has assertion: a(CHEBI:"hydrogen peroxide") -| a(SCHEM:"Adenosine triphosphate")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.715+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -| a(SCHEM:"Adenosine triphosphate")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1928218

2
value: Interaction of hydrogen peroxide with endothelial cells rapidly depletes adenosine triphosphate (ATP) and causes the extracellular appearance of xanthine and hypoxanthine.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1928218

Selventa

RAc5YZYMVuPFLXU4517a44oQIm2OeV2TCrmYXDAP14OW0
has assertion: p(HGNC:IDO1) -> r(HGNC:IL2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.720+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IDO1) -> r(HGNC:IL2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1929607

4
value: Indo increased IL-2 production by sup burn PBMCs significantly more (160% +/- 20%, p less than 0.005) than control (57% +/- 5%) and nonsup PBMCs (67% +/- 8%).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1929607

Selventa

RAVBu43bNAQhbf8W9DjYTgRfFCQ4caP4gOtRi1a3BL40o
has assertion: bp(GO:"response to hypoxia") -> tscript(p(HGNC:HIF1A))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.727+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> tscript(p(HGNC:HIF1A))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19305150

4
value: The results showed a reduction of HIF-1a mRNA (A) by siHIF-1a and of HIF-2a mRNA (B) by siHIF-2a, simultaneously CCR7 mRNA was reduced more significantly in siHIF-1a than siHIF-2a tansfected cells. These effects were also confirmed on protein levels (C).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19305150

Selventa

RAfJ2DASX9aaovCw2VRQcl37msEfF0VQgV3-hVMk8eKVM
has assertion: p(MGI:Maoa) -| bp(GO:"response to stress")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.730+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Maoa) -| bp(GO:"response to stress")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19307700

3
value: MAO-A knockout mice have elevated brain levels of serotonin, norepinephrine and, to a lesser extent, dopamine [17], whereas only 2-phenylethylamine levels are increased in MAO-B knockout mice [79]. Both MAO-A and -B knockout mice show an increased response to stress, similar to that observed after the administration of non-selective MAO inhibitors.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19307700

Selventa

RAR3rCwkNPHu0uE7gxGylGgVtOmcBOa7dh2L6qsvoPJjU
has assertion: p(MGI:Maob) -| bp(GO:"response to stress")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.732+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Maob) -| bp(GO:"response to stress")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19307700

3
value: MAO-A knockout mice have elevated brain levels of serotonin, norepinephrine and, to a lesser extent, dopamine [17], whereas only 2-phenylethylamine levels are increased in MAO-B knockout mice [79]. Both MAO-A and -B knockout mice show an increased response to stress, similar to that observed after the administration of non-selective MAO inhibitors.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19307700

Selventa

RAXX-Vv9f3wfnupB7ZmDNgrHtcBvYxQ4XuKx6ZwhNPU1o
has assertion: cat(p(MGI:Lpl)) rateLimitingStepOf path(SDIS:"VLDL biosynthesis")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.742+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(MGI:Lpl)) rateLimitingStepOf path(SDIS:"VLDL biosynthesis")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19318514

4
value: LPL is the rate-limiting enzyme for the hydrolysis of the triglyceride (TG) core of circulating TG-rich lipoproteins, chylomicrons, and very low-density lipoproteins (VLDL). LPL-catalyzed reaction products, fatty acids, and monoacylglycerol are in part taken up by the tissues locally and processed differentially; e.g., they are stored as neutral lipids in adipose tissue, oxidized, or stored in skeletal and cardiac muscle or as cholesteryl ester and TG in macrophages.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19318514

Selventa

RARwMoTS3mOhW-htGw63Z1CXU1AxMgEeH3elne0ridOFA
has assertion: p(MGI:Lpl) -| bp(MESHPP:Obesity)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.745+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Lpl) -| bp(MESHPP:Obesity)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19318514

3
value: To examine this divergent regulation further, transgenic and knockout murine models of tissue-specific LPL expression have been developed. Mice with overexpression of LPL in skeletal muscle accumulate TG in muscle, develop insulin resistance, are protected from excessive weight gain, and increase their metabolic rate in the cold.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19318514

Selventa

RAXxCuGdKol 57TmloVTfc7PVD0YnxdeUl71RTJH8y7mw
has assertion: a(CHEBI:erlotinib) -| p(PFH:"AKT Family",pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.752+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:erlotinib) -| p(PFH:"AKT Family",pmod(P))
label: p(HGNC:PTEN) -> (a(CHEBI:erlotinib) -| p(PFH:"AKT Family",pmod(P)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19351834

5
value: PTEN loss in PC9 cells (PC9PTENkd) induced the uncoupling of EGFR and downstream Akt signaling as shown by continuous Akt phosphorylation under erlotinib treatment (Fig. 3B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19351834

Selventa

RAXJFZkVQVloc0lmVIab9dLSdxsAlGgnqFGB4orct63w8
has assertion: p(HGNC:SIRT1) -| p(HGNC:DKK1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.757+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:SIRT1) -| p(HGNC:DKK1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19351856

4
value: Correlative Western blot experiments showed that EZH2, SirT1, and combined EZH2/SirT1 knockdown modestly increased Dkk-1 protein levels in untreated Calu-6cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19351856

Selventa

RAYXX6elEdoA8XdPS2a2Qun8jmNTglbPxuqhm74ggLXk8
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:MMP9)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.769+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:MMP9)
label: a(SCHEM:Splitomicin) -| (a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:MMP9))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19376817

4
value: Pretreatment with the nonspecific sirtuin inhibitor splitomycin (1?100 M) significantly enhanced PMA-induced MMP9 expression in a concentration- dependent manner (Fig. 1A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19376817

Selventa

RAbdYBrZe u 0bL7M4S8sX988KT0SJE2JjRL5evmbp7x0
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:MMP9)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.773+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:MMP9)
label: a(SCHEM:Splitomicin) -| (a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:MMP9))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19376817

4
value: Pretreatment with the nonspecific sirtuin inhibitor splitomycin (1?100 M) significantly enhanced PMA-induced MMP9 expression in a concentration- dependent manner (Fig. 1A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19376817

Selventa

RAWkF3GSqqtY7Ue1r6SkogBf1u3ALObnjVlUTW1QeVVBQ
has assertion: p(HGNC:SIRT1) -| p(HGNC:MMP9)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.777+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:SIRT1) -| p(HGNC:MMP9)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19376817

4
value: SIRT1 knockdown increased the amount of the lower-molecular- weight active form (85–88 kDa) of MMP9, which was shown by zymography (Fig. 1C, center panel).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19376817

Selventa

RAQoFUTuN1RQOSBZC0c4pM6oiLOvxOy58-lbnOfsKE1LA
has assertion: kin(p(HGNC:MAPK3)) => p(HGNC:MBP,pmod(P,T,232))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.782+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK3)) => p(HGNC:MBP,pmod(P,T,232))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1939237

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1939237

Selventa

RAZ6uiPw-Z6-8rgGyddA9X1LbLslo8opl5FrsZrem-wuE
has assertion: a(CHEBI:fenofibrate) -> r(RGD:Acox1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.784+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:fenofibrate) -> r(RGD:Acox1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19395589

3
value: Additionally, expression of PDK4, CPT1-M {Official Gene Symbol: CPT1B}, CPT2, and FACO {Official Gene Symbol: ACOX1} mRNAs was increased.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19395589

Selventa

RAbm409uWng89DP22UBwO4HsEg3wuf0n WPMRXgG6g1wo
has assertion: p(HGNC:NFE2L2) -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.794+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NFE2L2) -> bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19417020

3
value: Knockdown of Nrf2 with Nrf2-siRNA potently inhibited the proliferation of A549 cells (Fig. 2D, left).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19417020

Selventa

RAVXQzU-Z--UZ1JqK59M6GKqC0tusmQ3sfYHjrLtKWJKU
has assertion: a(CHEBI:cisplatin) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.795+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:cisplatin) -> bp(MESHPP:Apoptosis)
label: p(HGNC:NFE2L2) -| (a(CHEBI:cisplatin) -> bp(MESHPP:Apoptosis))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19417020

4
value: Nrf2 knockdown augmented CDDP-induced DNA interstrand crosslink formation and apoptosis in A549 cells... The proportion of both early apoptotic cells that were positive for only Annexin V and late apoptotic cells that were positive for both Annexin V and propidium iodide was significantly increased in Nrf2-siRNAtransfected A549 cells compared with NC-siRNA-transfected A549 cells (Fig. 4B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19417020

Selventa

RAfnC0Ov6P6xz5Xagpt2N7XuNT-67xoRE0bKaTbK3byPw
has assertion: tscript(p(MGI:Stat6)) -> bp(GO:"inflammatory response")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.796+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Stat6)) -> bp(GO:"inflammatory response")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19419769

4
value: IL-4 develops Th2-biased immunity or allergic inflammation through activation of STAT6-dependent signaling.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19419769

Selventa

RAcXDuafyiVMKcA11Zk4PX8 XHwcEE2 rkcgPv5Y0Ggcg
has assertion: p(HGNC:C3) -> cat(p(HGNC:DGAT1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.805+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:C3) -> cat(p(HGNC:DGAT1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1943492

5
value: Acylation stimulating protein (ASP) is a 14 kDa plasma protein which causes in vitro triacylglycerol synthesis in human adipocytes and fibroblasts to increase substantially. ASP was found to stimulate human adipose tissue microsomal glycerophosphate acyltransferase and diacylglycerol acyltransferase activities by 23% and 90%.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1943492

Selventa

RAf-VsFzC2LO67PYv7lHbXR8BDudcWhj7sT5T5rCmNohA
has assertion: a(CHEBI:ceramide) -| p(HGNC:UCP3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.809+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:ceramide) -| p(HGNC:UCP3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19435851

3
value: Moreover, ceramide directly induced SOCS-3 and inhibited UCP3 mRNA in cultured adipocytes suggesting a direct role for ceramide in regulation of metabolism and energy expenditure.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19435851

Selventa

RAfdZfwApoiGj-O7m-7kvXVewbG6bc6 vHVKvIIEXziDo
has assertion: p(EGID:64798) -| kin(p(PFH:"AKT Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.817+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:64798) -| kin(p(PFH:"AKT Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19446321

5
value: Loss of DEPTOR activates S6K1, Akt, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19446321

Selventa

RAWk7D8MiCveDBgZlbb62hUvxS0Q82V8PSmontSzEuIZc
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:ADM)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.819+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:ADM)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19454749

3
value: Here we show that the gene expression profile in primary human and murine macrophages changes markedly when they are exposed to hypoxia for 18 hours. For example, they were seen to up-regulate the cell surface receptors, CXCR4 and GLUT1, and the potent, tumor-promoting cytokines, vascular endothelial growth factor A, interleukin (IL)-1beta and IL-8, adrenomedullin, CXCR4, and angiopoietin-2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19454749

Selventa

RAcD9xS7B9Y5RyvsLvEg gwQIPiNbPA4NcYhwl-vyKNMI
has assertion: bp(GO:"response to hypoxia") -> r(MGI:Adm)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.821+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(MGI:Adm)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19454749

3
value: Here we show that the gene expression profile in primary human and murine macrophages changes markedly when they are exposed to hypoxia for 18 hours. For example, they were seen to up-regulate the cell surface receptors, CXCR4 and GLUT1, and the potent, tumor-promoting cytokines, vascular endothelial growth factor A, interleukin (IL)-1beta and IL-8, adrenomedullin, CXCR4, and angiopoietin-2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19454749

Selventa

RAaROYe s3qqy88EcjNrnCOkp0-JEtre5MUxWPIBZFPOQ
has assertion: bp(GO:"response to hypoxia") -> r(MGI:Vegfa)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.830+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(MGI:Vegfa)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19454749

3
value: Here we show that the gene expression profile in primary human and murine macrophages changes markedly when they are exposed to hypoxia for 18 hours. For example, they were seen to up-regulate the cell surface receptors, CXCR4 and GLUT1, and the potent, tumor-promoting cytokines, vascular endothelial growth factor A, interleukin (IL)-1beta and IL-8, adrenomedullin, CXCR4, and angiopoietin-2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19454749

Selventa

RAe6 0JRK7Gmmvspgr81fpXM37zRJBPMxqR0rb14cPpq8
has assertion: bp(GO:"response to hypoxia") -> tscript(p(HGNC:EPAS1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.831+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> tscript(p(HGNC:EPAS1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19454749

4
value: These studies showed that both HIF-1 and -2, but not NF-kappaB, are important transcriptional effectors regulating the responses of macrophages to such a period of hypoxia
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19454749

Selventa

RASkDbh7dxYve2bBSWKvEPdXTiHWugxXRTp0S3rLKwO9g
has assertion: bp(GO:"response to hypoxia") -> tscript(p(MGI:Hif1a))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.835+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> tscript(p(MGI:Hif1a))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19454749

4
value: These studies showed that both HIF-1 and -2, but not NF-kappaB, are important transcriptional effectors regulating the responses of macrophages to such a period of hypoxia
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19454749

Selventa

RAXVtiK 0eNBWKvcmi0KtlaO3-jlPE1Mj lfeW7z 6cAQ
has assertion: kin(p(EGID:20963)) -> cat(p(MGI:Vav1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.837+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(EGID:20963)) -> cat(p(MGI:Vav1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19461045

6
value: TLR4 and Syk were required for mmLDL activation of guanine nucleotide exchanging factor Vav1, small GTPase Ras, kinases Raf, MEK1 and ERK1/2; in turn, ERK1/2 phosphorylated paxillin at Ser126 and activated small GTPases Cdc42, Rac and Rho (Figure 3 and Online Figure III). These signaling events lead to actin polymerization, a necessary step in membrane ruffling. Our results agree with the reports of Syk-dependent ERK1/2 activation in phagocytosis45, ERK1/2 activation in TLR4-dependent antigen uptake by dendritic cells46, and the role of paxillin and small GTPases in actin reorganization and pinocytic vesicle formation9,26,27,47.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19461045

Selventa

RAakSj9AMmwyiCnMz-qMhiX9tBeQWRPpf8 tMCIgPT1sE
has assertion: bp(GO:"response to hypoxia") -> a(CHEBI:"thromboxane B2")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.842+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> a(CHEBI:"thromboxane B2")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/1947460

2
value: Hypoxia induced a very large increase in plasma concentration of most eicosanoids; thromboxane B2 (TxB2) and leukotriene B4 (LTB4) were maximum at H1 and H2 (about 5 times the normoxic value); prostaglandins PGE2, 6-keto-PGF1 alpha and PGF2 alpha were maximum at H3 or H4 (about 2.5-5 times of normoxic value).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/1947460

Selventa

RAYo76RPchWLMEQ8Xg0YOfyeIH4EsnSMm xCQO O1Rcro
has assertion: p(HGNC:GSK3B,pmod(P,S,9)) =| kin(p(HGNC:GSK3B))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.855+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:GSK3B,pmod(P,S,9)) =| kin(p(HGNC:GSK3B))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19506320

5
value: . A major mechanism of cell necrosis is the opening of the mitochondrial permeability transition pore (mPTP), which consists of multiple protein subunits, including adenine nucleotide translocase (ANT). The threshold for mPTP opening is elevated by phosphorylation of GSK-3beta at Ser9, which reduces activity of this kinase. {FROM FULL TEST: The mPTP is a non-selective large conductance channel in the mitochondrial inner membrane, which is physiologically closed. Opening of mPTPs is involved in cell death induced by a variety of causes (for example, ischemia/reperfusion, alcohol, endotoxin, anti-cancer agents), therefore 'opening' is modeled as tportof(mitochondrial permeability transition pore) and increased threshold for opening is modeled as decrease in tportof -SE}
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19506320

Selventa

RAXAq7YUbvy9qvs-YL3dKyfsawcOlUgGC0gTMWFPo2R6c
has assertion: a(CHEBI:"hydrogen peroxide") -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.862+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> a(CHEBI:"reactive oxygen species")
label: p(MGI:Keap1) -> (a(CHEBI:"hydrogen peroxide") -> a(CHEBI:"reactive oxygen species"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19520915

4
value: However, after exposure to 100 ?M hydrogen peroxide the levels of ROS was significantly decreased in Keap1?2-3/?2-3;CctCre+ mice compared to Keap1flox/flox mice (Figure 4B and D, respectively)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19520915

Selventa

RAez49KIqievCwefSQWKguGusHZt -4Mhhj78HIBM5dWw
has assertion: m(HGNC:"MIR16-1") -| bp(GO:"cell cycle")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.869+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:"MIR16-1") -| bp(GO:"cell cycle")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19549910

3
value: Consistent with these results, overexpression of these miRNAs induces cell cycle arrest in G(1)-G(0)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19549910

Selventa

RAQ37HvednYLQ1nn7wWOZDrJchGPxbRSkxyJOxzKgcPs8
has assertion: m(HGNC:"MIR16-1") -| r(HGNC:CCND1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.870+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:"MIR16-1") -| r(HGNC:CCND1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19549910

4
value: from full text Results - All cell lines transfected with miR-15a/miR-16 precursors gave rise to reduced levels of CCND1, CCND3, and CCNE1 mRNAs relative to the control transfected with an unrelated RNA (cell lines from Fig 3)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19549910

Selventa

RAZHvqk217 1AL4KQXk9Tg4xgSQue42Xm6EvxH3bOEyNs
has assertion: m(HGNC:"MIR16-1") -| r(HGNC:CCNE1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.876+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:"MIR16-1") -| r(HGNC:CCNE1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19549910

4
value: from full text Results - All cell lines transfected with miR-15a/miR-16 precursors gave rise to reduced levels of CCND1, CCND3, and CCNE1 mRNAs relative to the control transfected with an unrelated RNA (cell lines from Fig 3)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19549910

Selventa

RAfbQURIfn73yIHFsx5z2B5e-te7y1zp5UKRoWDc4mXOY
has assertion: m(HGNC:MIR21) =| r(HGNC:LRRFIP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.879+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

m(HGNC:MIR21) =| r(HGNC:LRRFIP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19559015

4
value: We further identified and validated LRRFIP1, whose product is an inhibitor of NF-kappaB signaling, as a direct target gene of miR-21
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19559015

Selventa

RAZLM9nrAphQ0fQjblwDWW2jIsxd--RzheHd8Xbo6AsSY
has assertion: p(HGNC:DNM1) -> (p(HGNC:EGF) -> kin(p(HGNC:MAPK1)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.889+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:DNM1) -> (p(HGNC:EGF) -> kin(p(HGNC:MAPK1)))
label: p(HGNC:EGF) -> kin(p(HGNC:MAPK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19570984

7
value: The expression of dn-dynamin (Fig. 7B) resulted in an 2-fold decrease in ERK1/2 activation in response to EGF stimulation (Fig. 7, A and C);
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19570984

Selventa

RAUAAy0qtSQjD6nirwSEtmvvB4S78Nt9oMYBZHqn3UTyI
has assertion: p(HGNC:F2) => cat(p(HGNC:F2R))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.892+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:F2) => cat(p(HGNC:F2R))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19572074

5
value: Thrombin, on the other hand, has been studied extensively in platelets. As one of the major platelet agonists, it activates the protease activated receptor 1 and 4 (PAR1/4) on the platelet surface which leads to activation of PI3K and phospholipase C? (PLC?) pathways.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19572074

Selventa

RAd1hqf1-i6dIeM5-BNz3tXqpD33i6HCH-3bS-7XRasT4
has assertion: cat(p(HGNC:F2R)) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.894+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:F2R)) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19572074

5
value: Thrombin, on the other hand, has been studied extensively in platelets. As one of the major platelet agonists, it activates the protease activated receptor 1 and 4 (PAR1/4) on the platelet surface which leads to activation of PI3K and phospholipase C? (PLC?) pathways.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19572074

Selventa

RAXXNniZENEEzj8dT4CR9ZUUEfRL0QFjBvzQsfMzlT7-w
has assertion: p(HGNC:MUC1) -> bp(GO:"cell migration")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.903+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MUC1) -> bp(GO:"cell migration")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19578748

3
value: As shown in Fig. 4D, cells exposed to siRNA against MUC1 demonstrated statistically significant reductions in both migration and invasion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19578748

Selventa

RARpcKkHNKLaWMiBF6qTkmOJxg10MC5ACHnGSsKjfsjQc
has assertion: p(HGNC:MUC1) -> p(PFH:"AKT Family",pmod(P,S,473))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.904+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MUC1) -> p(PFH:"AKT Family",pmod(P,S,473))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19578748

4
value: Exposure of these cell lines to MUC1 siRNA was associated with downregulation of MUC1 protein (Fig. 3A). As shown in Fig. 3A, transfection of cells with MUC1 siRNA resulted in downregulation of phosphorylated tyrosine STAT3, Src, and FAK. The phosphorylated serine Akt, however, was downregulated by MUC1 siRNA only in H358 cells but not in HCC827 and H441 cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19578748

Selventa

RAU3GNRf4mwh5OBb9078bc T Zv-IwJskJ 8WBM7P90lM
has assertion: p(MGI:Muc1) -> p(MGI:Mki67)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.910+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Muc1) -> p(MGI:Mki67)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19578748

4
value: Measurement of the percentage of cells positive for ApopTag showed that MUC1 knockdown resulted in a significant increase in apoptosis compared with the control (Fig. 5A). MUC1 siRNA-transfected cells also expressed less Ki-67 indicative of reduced proliferation of these cells in vivo.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19578748

Selventa

RAVUuHnaxiQV4vAKVvf1zV886-vfBtulu9lm-UrwiPEm4
has assertion: cat(p(MGI:S1pr1)) -> bp(GO:"regulation of vascular permeability")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.921+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(MGI:S1pr1)) -> bp(GO:"regulation of vascular permeability")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19603543

4
value: Increased leak was associated with increased interendothelial cell gaps in venules and was reversed by transfusion with wild-type erythrocytes (which restored plasma S1P levels) and by acute treatment with an agonist for the S1P receptor 1 (S1pr1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19603543

Selventa

RAdAr7uyDHFSmUimuCqOHzlKTIDgXdt526turTXcYwHTI
has assertion: kin(complex(NCH:"AMP Activated Protein Kinase Complex")) =| cat(p(HGNC:HMGCR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.923+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"AMP Activated Protein Kinase Complex")) =| cat(p(HGNC:HMGCR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19608989

5
value: AMP-activated protein kinase (AMPK) was initially identified as the kinase that phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase {inhibitor phosphorylation-SE}
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19608989

Selventa

RAb4vg3W0fpRP2fcSNd7QzFqqHblunzhDSISmgoYXvmko
has assertion: a(SCHEM:"NS 398") -| cat(p(MGI:Ptgs2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.932+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"NS 398") -| cat(p(MGI:Ptgs2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19646463

4
value: Carrageenin-induced acute lung inflammation was also exacerbated in Nrf2?/? mice compared with Nrf2+/+ mice (Mochizuki et al., 2005). A selective COX-2 inhibitor (NS-398) suppressed the antiinflammatory 15-deoxy-delta (12,14)-prostaglandin J2 (15d-PGJ2) accumulation and ARE responsiveness, and caused greater lung injury in Nrf2?/? mice than in Nrf2+/+ mice (Mochizuki et al., 2005).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19646463

Selventa

RAePsU6eVL k81-cuCW6qKTXT YD2VwKFS1v956Uv-hI
has assertion: a(CHEBI:"hydrogen peroxide") -> cat(p(RGD:Gss))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.936+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> cat(p(RGD:Gss))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19646463

4
value: Enhanced mRNA expression and enzyme activity of NQO1 and gamma glutamyl cysteine ligase (GCL) were elicited by oxidant exposure (e.g., hyperoxia, hydrogen peroxide) in pulmonary tissues or cells (Whitney and Frank, 1993; Rahman et al., 1996).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19646463

Selventa

RARQP3Qm-ETohOXXyRrYi3ODsrZORYSK8CRY-B1QhV0R0
has assertion: a(CHEBI:"hydrogen peroxide") -> r(RGD:Gss)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.937+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> r(RGD:Gss)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19646463

3
value: Enhanced mRNA expression and enzyme activity of NQO1 and gamma glutamyl cysteine ligase (GCL) were elicited by oxidant exposure (e.g., hyperoxia, hydrogen peroxide) in pulmonary tissues or cells (Whitney and Frank, 1993; Rahman et al., 1996).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19646463

Selventa

RAVljdAcgpzjNvkmQWzqs7eZW-nSueGjtcVF8BfsPo4bA
has assertion: path(MESHD:Hyperoxia) -> r(RGD:Nqo1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.943+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Hyperoxia) -> r(RGD:Nqo1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19646463

3
value: Enhanced mRNA expression and enzyme activity of NQO1 and gamma glutamyl cysteine ligase (GCL) were elicited by oxidant exposure (e.g., hyperoxia, hydrogen peroxide) in pulmonary tissues or cells (Whitney and Frank, 1993; Rahman et al., 1996).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19646463

Selventa

RAaM20C9FYW-hvKBGX UlukRD1gOEluMZT PR HO4U VY
has assertion: p(MGI:Nfe2l2) -| bp(GO:"inflammatory response")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.944+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Nfe2l2) -| bp(GO:"inflammatory response")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19646463

3
value: In an experimental sepsis model, Nrf2 deficiency increased the inflammation and mortality of mice against bacterial endotoxin (LPS)- and cecal ligation and puncture-induced septic shock (Thimmulappa et al., 2006a).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19646463

Selventa

RAaV-LDA9jh0hl2Za-WuLHyL29qotYQa3DxtO81UCIXzU
has assertion: kin(p(PFM:"Akt Family")) -| r(MGI:Cdkn1b)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.947+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFM:"Akt Family")) -| r(MGI:Cdkn1b)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19648963

5
value: The Ras effector Akt is known to regulate p27 mRNA abundance by phosphorylating and inactivating the FOXO transcription factors. Phosphorylated Akt and FOXO proteins were both increased in lung tumors, correlating with a reduction in p27 mRNA transcript.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19648963

Selventa

RAfRf2MQ8Nq-Qawwths70IJbHTYp4kq4uVMY83Ym05 xo
has assertion: kin(complex(NCM:"p85/p110 PI3Kinase Complex")) -| tscript(p(PFM:"Foxo Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.950+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCM:"p85/p110 PI3Kinase Complex")) -| tscript(p(PFM:"Foxo Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19648963

5
value: from full text Results - Treatment of the mouse lung tumor cell line SP10 with LY294002 led to a reduction of phospho-Akt, a reduction in phospho- FOXO, and an increase in both p27 transcript and protein levels - LY294002 not in system
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19648963

Selventa

RAdlTtsaBGBp3lad5Dh1Bk61Icx4cl06DqFJgWeDoh1Ac
has assertion: kin(p(PFH:"PRKA Family")) => p(HGNC:RAP1B,pmod(P,S,179))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.951+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKA Family")) => p(HGNC:RAP1B,pmod(P,S,179))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19651783

5
value: Rap1b has been implicated in the transduction of the cAMP mitogenic response. Agonists that increase intracellular cAMP rapidly activate (i.e. GTP binding) and phosphorylate Rap1b on Ser(179) at its C terminus.cAMP-dependent protein kinase (PKA)-mediated phosphorylation of Rap1b is required for cAMP-dependent mitogenesis, tumorigenesis, and inhibition of AKT activity
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19651783

Selventa

RAZvRsXslg Zr3C4T31lAM6FBjyM8Xi4cssdYezSosogU
has assertion: path(MESHD:Hyperoxia) -> kin(p(MGI:Mapk3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.956+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Hyperoxia) -> kin(p(MGI:Mapk3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19661248

4
value: Hyperoxia was associated with a significant increase in pJNKs and pERKs in WT mice as seen by Western blot. NOX1, but not NOX2, deficiency decreased ERK and JNK phosphorylation without modification of JNK and ERK protein levels (Figures 7A?7F).NOX1, but not NOX2, deficiency decreased ERK and JNK phosphorylation without modification of JNK and ERK protein levels (Figures 7A?7F). pERK staining was associated with type II pneumocytes and endothelial cell markers during hyperoxia (Figure 8A), whereas pJNK staining was detected mainly in endothelial cells (Figure 8B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19661248

Selventa

RAd46PBFrBUwb4yKOjimWCc1pWOb6EdVTuAGB3Zy7XLZQ
has assertion: p(MGI:Nox1) -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.957+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Nox1) -> a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19661248

3
value: These results indicate that NOX1 but not NOX2 is mainly responsible for ROS formation in lungs and in primary type II AECs and MLECs
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19661248

Selventa

RAQ3oe1MccrQkLmMPmc7KQ38UiluNorTJB4jZiht4UVW0
has assertion: p(HGNC:PTEN) -| kin(p(PFH:"AKT Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.961+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PTEN) -| kin(p(PFH:"AKT Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19663788

5
value: Jin et al. [78] reported that wild PTEN gene delivery significantly inhibited lung cancer growth by inactivation of Akt signal. PDCD4 gene delivery also significantly inhibited lung tumorigenesis and induced apoptosis in lung cancer mice model [79, 80].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19663788

Selventa

RAUEpe4bDHJkFLJsFj8DUaONsPgaAzug1VOu9FVqXEONY
has assertion: a(SCHEM:Mapatumumab) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.962+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Mapatumumab) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19663788

2
value: Mapatumuma is fully human monoclonal antibodies that bind and activate TRAIL-1 [73], and mapatumuma treatment significantly inhibits lung cancer growth through inducing the apoptosis in in vitro as well as in vivo model [74].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19663788

Selventa

RAVJHRpjC8coJV5JiTUAfqFNzsUMlkna9f4UPQ53tWlNE
has assertion: a(CHEBI:erlotinib) -| kin(p(PFH:"MAPK Erk1/3 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.980+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:erlotinib) -| kin(p(PFH:"MAPK Erk1/3 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19671683

4
value: Erlotinib decreased cellular levels of phosphorylated ERK1/2, phosphorylated AKT, Rad51 protein, and mRNA in erlotinib-sensitive H1650, A549, and H1869 cells, leading to cell death via apoptosis (also Erlotinib decreased Rad51 protein levels by enhancing Rad51 mRNA and protein instability, so will add protein as well as exp)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19671683

Selventa

RAcXMzhuAREkkY0lKXIGru-2oJCA4s8CNwfDQkM3z3WNM
has assertion: p(HGNC:RAD51) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.984+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:RAD51) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19671683

3
value: overexpression of Rad51 by transfection with Rad51 vector could protect the cells from cytotoxic effects
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19671683

Selventa

RAfCXImPylDITeA66DKYe-tyiofNvwkCitfaAltAxqybU
has assertion: p(HGNC:AVP) => cat(p(HGNC:AVPR2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:54.989+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:AVP) => cat(p(HGNC:AVPR2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19693000

5
value: The neurohypophyseal peptide [Arg8]-vasopressin (AVP) is involved in diverse functions including regulation of body fluid homeostasis, vasoconstriction, and adrenocorticotropic hormone release. These physiological effects are mediated by three subtypes of AVP receptors, designated V1a, V1b, and V2.1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19693000

Selventa

RAem1Uu OZsgFctJOKqA 6VztadeHwUNpGkBw1-2LxNHs
has assertion: a(CHEBI:"sorafenib tosylate") =| kin(p(HGNC:PDGFRB))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.060+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"sorafenib tosylate") =| kin(p(HGNC:PDGFRB))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19763051

4
value: from full text - Sorafenib is a potent TKI of VEGFR-2, VEGFR-3, B-RAF, and PDGFR-B
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19763051

Selventa

RAUq3ANoG-r2bAaALhnV0Yvt5deKLNI3ga0 GQYz4e7Ow
has assertion: kin(p(PFH:"MAPK Erk1/3 Family")) -> r(HGNC:SPP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.076+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"MAPK Erk1/3 Family")) -> r(HGNC:SPP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19798549

5
value: Further, ERK inhibitor inhibited significantly OPN expression, Elk1 phosphorylation, and activator protein-1 (AP-1)-DNA binding activation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19798549

Selventa

RAWQ8Wa9jUx7DytPLFkaZsxYA9dVD7qFRBM8caYnzIhlU
has assertion: p(HGNC:PTK2) -> kin(p(PFH:"MAPK Erk1/3 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.079+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PTK2) -> kin(p(PFH:"MAPK Erk1/3 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19798549

5
value: Transfecting hPLFs with FAK (Official Gene Symbol: PTK2) antisense oligonucleotide diminished ERK1/2 activation and force-induced OPN (Official Gene Symbol: SPP1) expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19798549

Selventa

RAQgTQKSssIowhaxRH8WzDU5Bbi9YddS7 0u1eXkYRNdY
has assertion: a(SCHEM:Sirolimus) -> r(RGD:Bckdha)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.083+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Sirolimus) -> r(RGD:Bckdha)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19816606

3
value: Table S1 - Genes that show differential expression in response to rapamycin in WB-F344 (non-tumorigenic rat liver epithelial cell line)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19816606

Selventa

RAZuaIJhgcP-BvvdsCoA8ZqyMtYXcCzETcqa9IbOlYOGk
has assertion: tscript(complex(NCH:"Nfkb Complex")) -> p(HGNC:SOD2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.091+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"Nfkb Complex")) -> p(HGNC:SOD2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19826058

4
value: We have shown previously that NHEK senescence arises in part through hydrogen peroxide (H2O2) accumulation. This accumulation was shown to result from an activation of NF-nB and ensuing up-regulation of MnSOD, responsible for the dismutation of O2 to H2O2. Without any coup- regulation of downstream H2O2-degrading enzymes, this leads to H2O2 accumulation (23).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19826058

Selventa

RAfUkxDRVjpnvBl6aeKR97pstHB33Vs8Ryn0ZS-v1mzUk
has assertion: a(CHEBI:lipopolysaccharide) -> p(HGNC:CXCL1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.097+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> p(HGNC:CXCL1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19842832

3
value: AM Gro-alpha can be induced by LPS, and an approximate 50- to 100-fold increase in Gro-alpha expression was seen in LPS-stimulated AM when compared with nontreated cultures [167].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19842832

Selventa

RAT3I27Q5N3ZTKMvzMaHpfOteV2STg01hhwnYQJ4Gm6wk
has assertion: a(CHEBI:lipopolysaccharide) -> p(HGNC:IL1B)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.100+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> p(HGNC:IL1B)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19842832

3
value: Evaluation of BAL fluid supernatants recovered from human subjects at 90 and 240 minutes after LPS exposure revealed that the concentration of IL-1b was significantly increased in smokers (~12-fold) when compared with those of non-smokers (?6-fold).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19842832

Selventa

RAaZtSSWKKGmKeSz-hCd1RrlFat0S4oP2oafeceglorYM
has assertion: bp(GO:"inflammatory response") -> path(MESHD:Fibrosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.104+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"inflammatory response") -> path(MESHD:Fibrosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19855130

2
value: Hepatic fibrosis occurs during most chronic liver diseases and is driven by inflammatory responses to injured tissue.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19855130

Selventa

RAQY7iNf63zI8E2XiXcIwR6GJVvGYYLqUCWKBCiLNB7kk
has assertion: bp(GO:"response to hypoxia") -> tscript(p(HGNC:HIF1A))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.109+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> tscript(p(HGNC:HIF1A))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19880520

4
value: Our results suggest that activation of HIF-1alpha by hypoxia decreases HDAC2 levels, resulting in amplified inflammation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19880520

Selventa

RAUgS5uNLC iBww48vEcr9HbQqso2036WB9bdcQLC9uxU
has assertion: a(CHEBI:"nitric oxide") -> r(HGNC:HMOX1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.113+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> r(HGNC:HMOX1)
label: a(CHEBI:genistein) -| (a(CHEBI:"nitric oxide") -> r(HGNC:HMOX1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19892011

4
value: As seen in Table 1, SB 203580, a specific inhibitor of p38 MAPK, as well as genistein, a broad-spectrum tyrosine kinase inhibitor, completely suppressed gene induction of a selection of NO-responsive genes in cells exposed to DPTA-NO for 3 h.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19892011

Selventa

RAXq9WZ3RxAkzAwMq8kgWUIr19cSwlggcn83gmb77M4zs
has assertion: a(CHEBI:"nitric oxide") -> r(HGNC:ATF3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.120+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> r(HGNC:ATF3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19892011

3
value: Figure 1 - Comparison of mRNA levels of genes sensitive to various NO fluxes. U937 cells were exposed to (A) 500 ?M DPTA-NO for 3 h or (B) 200 uM DETA-NO for 17 h. mRNA levels were measured by TaqMan low-density array analysis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19892011

Selventa

RAT66 wEX86K2uoxD QNycptciKjCt2D26gkTp2a98f8A
has assertion: a(CHEBI:"nitric oxide") -> r(HGNC:BNIP3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.122+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> r(HGNC:BNIP3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19892011

3
value: Figure 1 - Comparison of mRNA levels of genes sensitive to various NO fluxes. U937 cells were exposed to (A) 500 ?M DPTA-NO for 3 h or (B) 200 uM DETA-NO for 17 h. mRNA levels were measured by TaqMan low-density array analysis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19892011

Selventa

RAb7YydD6yx5k8VQe7bVsYbDBOAVMqCqDR0XJWmuyCmS8
has assertion: a(CHEBI:"nitric oxide") -> r(HGNC:CCL3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.123+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> r(HGNC:CCL3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19892011

3
value: Figure 1 - Comparison of mRNA levels of genes sensitive to various NO fluxes. U937 cells were exposed to (A) 500 ?M DPTA-NO for 3 h or (B) 200 uM DETA-NO for 17 h. mRNA levels were measured by TaqMan low-density array analysis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19892011

Selventa

RAZ419gQLPuGbjmX3eJ5qVWxcE6 MGXkiUXwMg-VqKfRE
has assertion: a(CHEBI:"nitric oxide") -> r(HGNC:CDKN1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.124+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> r(HGNC:CDKN1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19892011

3
value: Figure 1 - Comparison of mRNA levels of genes sensitive to various NO fluxes. U937 cells were exposed to (A) 500 ?M DPTA-NO for 3 h or (B) 200 uM DETA-NO for 17 h. mRNA levels were measured by TaqMan low-density array analysis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19892011

Selventa

RAfHOJ8E9la8mAXX3-KJbb0bFlsnWFbpCUPdMMz-pFdZo
has assertion: a(CHEBI:lipopolysaccharide) -> r(MGI:Bcl10)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.129+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(MGI:Bcl10)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19901347

3
value: Selventa analysis of microarray data: Inhaled LPS vs Control (16 weeks) - RMA normalization, Fold change > 2, minimum abundance of 150, BH FDR P-value < 0.001. Dataset can be found at GEO (GSE18341)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19901347

Selventa

RAYV4i0RIIUFFd7pO6YCoS3eIIaU8x5V waeKl3b-yczU
has assertion: a(CHEBI:lipopolysaccharide) -> r(MGI:Birc3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.130+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(MGI:Birc3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19901347

3
value: Selventa analysis of microarray data: Inhaled LPS vs Control (16 weeks) - RMA normalization, Fold change > 2, minimum abundance of 150, BH FDR P-value < 0.001. Dataset can be found at GEO (GSE18341)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19901347

Selventa

RAWeZtiekmAP5PLTUxcohv2o3BN7fVEbdoJK-1Kj8XK3Y
has assertion: a(CHEBI:lipopolysaccharide) -> r(MGI:Gch1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.146+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(MGI:Gch1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19901347

3
value: Selventa analysis of microarray data: Inhaled LPS vs Control (16 weeks) - RMA normalization, Fold change > 2, minimum abundance of 150, BH FDR P-value < 0.001. Dataset can be found at GEO (GSE18341)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19901347

Selventa

RAdxtwKR9YVyk7hPHX5JYCXc3Nt6fvBYU2BJdKafLLkkA
has assertion: a(CHEBI:lipopolysaccharide) -> r(MGI:Hbegf)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.147+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(MGI:Hbegf)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19901347

3
value: Selventa analysis of microarray data: Inhaled LPS vs Control (16 weeks) - RMA normalization, Fold change > 2, minimum abundance of 150, BH FDR P-value < 0.001. Dataset can be found at GEO (GSE18341)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19901347

Selventa

RAWASxtX-h3lzJne5Hbro704A6H 5-DXU6INHTa17QqH4
has assertion: a(CHEBI:lipopolysaccharide) -> r(MGI:Slc26a4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.155+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(MGI:Slc26a4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19901347

3
value: Selventa analysis of microarray data: Inhaled LPS vs Control (16 weeks) - RMA normalization, Fold change > 2, minimum abundance of 150, BH FDR P-value < 0.001. Dataset can be found at GEO (GSE18341)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19901347

Selventa

RAUtl-okhWkLilhF3oCqpaesHsBBHT6dfzWQnZxmIReYg
has assertion: p(HGNC:IFNG) -> p(HGNC:STAT3,pmod(P,Y,705))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.170+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IFNG) -> p(HGNC:STAT3,pmod(P,Y,705))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19917672

4
value: We therefore determined phosphorylation of the signaling molecules by IFN-gamma in macrophages. Time-course analysis of the cell extract revealed that STAT1 and STAT3 were phosphorylated as early as 5 min after exposure of the cells to IFN-gamma
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19917672

Selventa

RASRkUEwykPrHoA44mnVO3YiIX7sJJ82EvH5P0GBwXpDA
has assertion: path(SDIS:"laminar shear stress") -> kin(p(HGNC:KDR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.188+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"laminar shear stress") -> kin(p(HGNC:KDR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19929443

4
value: We found that FSS-mediated phosphorylation of VEGFR2, Akt, and eNOS were significantly decreased in CSE-treated cells in a concentrationdependent manner when compared with control treatments (p < 0.01; Fig. 2).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19929443

Selventa

RAef-S5GTtE4TzsrNREuV7fC6ZJOC ZN15OBQuD7yeFpA
has assertion: a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.192+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death")
label: p(MGI:Nfe2l2) -> (a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19931411

4
value: Likewise, siNrf2-transfected cells abolished the protective effect of eckol against H2O2-induced death (Fig. 4C), suggesting the involvement of Nrf2 transcription factor in eckol-mediated HO-1 gene induction and cytoprotection.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19931411

Selventa

RAWoYZ4pcvcPjHB4qtvAy6XPgKqXqVXu Iuw0sOq5l5Gw
has assertion: a(CHEBI:aldosterone) -> r(HGNC:IL6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.202+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:aldosterone) -> r(HGNC:IL6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/19939912

3
value: By contrast, selective MR stimulation with aldosterone promoted the expression of IL-6, PAI-1, chemerin and leptin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/19939912

Selventa

RAY4 798BgxViaQGOtl -4S2Xr1CrjLBsshFuX0xFIzWM
has assertion: p(HGNC:IL6) -> path(SDIS:"osteoclast activity")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.218+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL6) -> path(SDIS:"osteoclast activity")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20035059

3
value: These results indicate that OSCC provides a suitable microenvironment for osteoclast formation not only by producing IL-6 and PTHrP but also by stimulating stromal cells to synthesize IL-6.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20035059

Selventa

RAdLyha6fd7naipy3qmSN6qdUhQw pm0CSsbxKlafU31I
has assertion: kin(p(HGNC:PAK2)) =| tscript(p(HGNC:MYC))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.220+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PAK2)) =| tscript(p(HGNC:MYC))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20043278

6
value: Mutational inactivation of the Myc p21 activated kinase 2 (PAK2) phosphorylation sites increased Myc activity and further enhanced epidermal differentiation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20043278

Selventa

RAZtd5MClPnUwXsfMXKezo-pC0A6w EAP234jXIKLCxjE
has assertion: bp(GO:"response to hypoxia") -> tscript(p(HGNC:CREB1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.223+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> tscript(p(HGNC:CREB1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20054152

4
value: The transcription factor CREB (cAMP response element binding protein) was activated with decreasing oxygen tensions in both cell types. This effect was again more marked in A549 cells, demonstrating epithelial cells to be more oxygen sensitive.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20054152

Selventa

RAVF9p6JaJaxj5NvXZPCQh-nmDTqvMPTH-F6SEaiclow4
has assertion: bp(GO:"response to hypoxia") -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.227+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> bp(GO:"cell proliferation")
label: kin(p(HGNC:EGFR)) -> (bp(GO:"response to hypoxia") -> bp(GO:"cell proliferation"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20139181

5
value: Hypoxic hPMVEC had a twofold greater level of proliferation compared with normoxic controls, and this increase in proliferation was prevented by the addition of AG-1478 (a pharmacological inhibitor of EGFR).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20139181

Selventa

RAWeX6hfr9wqhJV1j6jRYD44F6YjXiqqTQA sHBrPNJrU
has assertion: bp(GO:"response to hypoxia") -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.229+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> bp(GO:"cell proliferation")
label: cat(p(HGNC:ARG2)) -> (bp(GO:"response to hypoxia") -> bp(GO:"cell proliferation"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20139181

5
value: The hypoxic induction of arginase II protein was prevented by treatment with AG-1478. Proliferation assays were performed in the presence of arginase inhibitors, and hypoxia-induced proliferation was also prevented by arginase inhibition.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20139181

Selventa

RAZ8iP0IzxdEpg45J6205Z9KDIby32BACd6SWHafJlk14
has assertion: a(CHEBI:lipopolysaccharide) -> r(MGI:Vcam1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.239+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(MGI:Vcam1)
label: p(MGI:Ilk) -> (a(CHEBI:lipopolysaccharide) -> r(MGI:Vcam1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20164118

5
value: Transfection with ILK-siRNA weakened LPS-induced ICAM-1 and VCAM-1 expression to 60 and 20% of the control values but did not affect LPS-induced expression of E-selectin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20164118

Selventa

RAd7T9nzxkCkdbljyLSFgUv4HH84C-IgRAEGPd75FxeoI
has assertion: kin(p(MGI:Mapk7)) -> tscript(p(MGI:Pparg))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.241+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Mapk7)) -> tscript(p(MGI:Pparg))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20185831

6
value: We demonstrate that Erk5 phosphorylation allows activation of PPARgamma transcription factor by displacement of SMRT co-repressor. PPARgamma, in turn is critical for NFkappaB activation, PEDF-dependent apoptosis, and anti-angiogenesis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20185831

Selventa

RAXrA7x6y4lLMmWG-aRife3BpoR5WTHwFMOpOTUNABJTE
has assertion: cat(p(HGNC:NOX1)) -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.247+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:NOX1)) -> a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20347035

4
value: Downregulation of Nrf2 by si-NOX1 could be prevented by the addition of the proteasome inhibitor MG132, suggesting that NOX1-derived ROS interfere with the redox dependent proteasomal degradation of Nrf2 (Fig. 3C).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20347035

Selventa

RAd5gi4cyOlp4nnCucDssNUyKIwDT39c3biruqSqeF3iU
has assertion: bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.251+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
label: p(HGNC:NOX1) -> (bp(GO:"response to hypoxia") -> p(HGNC:HIF1A))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20347035

5
value: Treatment of cells with si-Nrf2, si-Trx1, and si- NOX1 resulted in themost pronounced downregulation of HIF-1A in IH6 and was less apparent in H2 and H6, as demonstrated by Western blot (Fig. 6A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20347035

Selventa

RAbivZJVbBZTm CAQvPgymP4Ny5cY3rlugBDmIXmjc-RM
has assertion: bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.254+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
label: p(HGNC:TXN) -> (bp(GO:"response to hypoxia") -> p(HGNC:HIF1A))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20347035

5
value: Treatment of cells with si-Nrf2, si-Trx1, and si- NOX1 resulted in themost pronounced downregulation of HIF-1A in IH6 and was less apparent in H2 and H6, as demonstrated by Western blot (Fig. 6A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20347035

Selventa

RAWMYuMacUeENX0VL MUTqfSvBxTARERqxbhHCO4wWYxc
has assertion: bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.262+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> p(HGNC:HIF1A)
label: p(HGNC:TXN) -> (bp(GO:"response to hypoxia") -> p(HGNC:HIF1A))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20347035

5
value: we demonstrated that overexpression of Trx1 induced HIF-1A both in continuous (H2, H6) and in intermittent hypoxia (IH6) (Fig. 6C).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20347035

Selventa

RAZYYkFRASTcijbAKiICjUXL2YhjqmQnxtfmp1jrb2Qp0
has assertion: p(HGNC:TNF) -> tloc(p(HGNC:RELA),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.263+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> tloc(p(HGNC:RELA),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20351055

5
value: After GSH with H2O2 pretreatment for 30 min, TNF induced p65 nuclear translocation decreased (Fig. 1C) and there was no detectable induction of this process in H2O2- or GSH-treated ECs (Fig. 1D).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20351055

Selventa

RAVu99X2dyWDzSqqzEsqeNKQDQkRm7zRxhkKKL0tfBS7Q
has assertion: p(EGID:3630) -> bp(GO:"glucose import")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.272+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:3630) -> bp(GO:"glucose import")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20352060

3
value: In platelets, glucose uptake can be stimulated by thrombin or insulin and is primarily mediated by the glucose transporter, GLUT3 [40]. Glucose uptake stimulated by thrombin or insulin is reduced in the presence of the Akt inhibitor, ML-9, suggesting that Akt contributes to glucose uptake in platelets, as it does in skeletal muscle or adipocytes [40]. However, the role of Akt in glucose uptake is not responsible for its role in platelet aggregation, since insulin induces Akt phosphorylation in platelets, but not platelet aggregation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20352060

Selventa

RAWY3zPSP37Z99LNmCzQRm-AgWavcmkSyS9QiWe29s238
has assertion: bp(GO:"response to heat") -> r(HGNC:DNAJA4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.273+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to heat") -> r(HGNC:DNAJA4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20352393

3
value: To validate these microarray results, we then conducted qRT-PCR analyses for the gene targets that exhibited statistical significance: HSPA1A (Hsp70), HSPA6 (Hsp70), HSPA4L (Hsp70L), DNAJA4 (Hsp40), DNAJB1 (Hsp40), and HSPH1 (Hsp105) (Fig. 1b). For all of the genes tested, we found that the treatment group exhibited statistically significant increases in expression compared to the sham group.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20352393

Selventa

RAeHjznkR8V-5-SpJ-q7OKrTn-mapbsOvUCJFAri6pvLo
has assertion: bp(GO:"response to heat") -> r(HGNC:HSPH1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.277+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to heat") -> r(HGNC:HSPH1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20352393

3
value: To validate these microarray results, we then conducted qRT-PCR analyses for the gene targets that exhibited statistical significance: HSPA1A (Hsp70), HSPA6 (Hsp70), HSPA4L (Hsp70L), DNAJA4 (Hsp40), DNAJB1 (Hsp40), and HSPH1 (Hsp105) (Fig. 1b). For all of the genes tested, we found that the treatment group exhibited statistically significant increases in expression compared to the sham group.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20352393

Selventa

RAcGapaOpSugHTpgd6Jtlw8WmGiwge3rcKEYWaWO12Lyc
has assertion: bp(GO:"response to heat") -> r(HGNC:HSPA1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.278+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to heat") -> r(HGNC:HSPA1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20352393

3
value: To validate these microarray results, we then conducted qRT-PCR analyses for the gene targets that exhibited statistical significance: HSPA1A (Hsp70), HSPA6 (Hsp70), HSPA4L (Hsp70L), DNAJA4 (Hsp40), DNAJB1 (Hsp40), and HSPH1 (Hsp105) (Fig. 1b). For all of the genes tested, we found that the treatment group exhibited statistically significant increases in expression compared to the sham group.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20352393

Selventa

RASu1GLcGsO6xXaJ3zajNDhWjIzmXFXJyUv5LMyqhzkLg
has assertion: cat(p(HGNC:SMPD1)) -> a(CHEBI:ceramide)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.279+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:SMPD1)) -> a(CHEBI:ceramide)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20354226

4
value: As a result of sphingomyelin catabolism, aSMase produces ceramide (a lipid second messenger) (91).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20354226

Selventa

RAWLLuqqzruKy501SGVYcSbqb3 u4Gjz O9bX0 u0l7Uk
has assertion: cat(p(HGNC:TLR3)) -> tscript(p(HGNC:IRF3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.284+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:TLR3)) -> tscript(p(HGNC:IRF3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20375591

6
value: F ig. 2. Effect of Toll-like receptor signalling on macrophage cholesterol metabolism. Stimulation of TLR3 or TLR4 leads to TRIFdependent activation of IRF3, which inhibits transcription of liver X receptor-dependent genes, many of which (e.g. ATP-binding cassette transporter A1, PLTP, apoE and ABCG-1) are critically involved in the efflux of cholesterol from macrophages.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20375591

Selventa

RAUkKzz-ShsMQ5cm0dcnY5dXtE5TwUl1UejkwGQv0tfuM
has assertion: p(HGNC:TNF) -> kin(p(PFH:"MAPK JNK Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.291+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> kin(p(PFH:"MAPK JNK Family"))
label: p(HGNC:TNFAIP3) -| (p(HGNC:TNF) -> kin(p(PFH:"MAPK JNK Family")))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20448643

7
value: First, the ectopic expression of A20 drastically inhibits TNF-induced JNK activation and apoptosis in multiple cell types including those deficient of NF-??B activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20448643

Selventa

RARv0qUdROiQmrzioMFa2TSJ8d1hTEab-mGilVJAdEzYI
has assertion: cat(p(HGNC:PARP1)) -| cat(p(HGNC:SIRT1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.301+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:PARP1)) -| cat(p(HGNC:SIRT1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20493163

6
value: Inhibition of poly(ADP-ribose)-polymerase-1 (PARP-1) attenuated CS-induced autophagy via SIRT1 activation (Fig. 5).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20493163

Selventa

RAQQ1iPAe0Av6Kyrh0P1eFYx67gIQa A5A7Rp7kDGwjhE
has assertion: p(HGNC:EGF) -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.320+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20566383

3
value: cyclo H inhibits EGF-induced EGFR phosphorylation, EGF-induced ROS production and EGF-induced CD11b upregulation (Fig. 1H,J);
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20566383

Selventa

RAVsNsHUTw9FMgvLp479pxvtjrXAHPynDGoyLZ2k0OW-s
has assertion: a(SCHEM:Calcium) -> bp(MESHPP:"Protein Biosynthesis")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.323+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> bp(MESHPP:"Protein Biosynthesis")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2059198

2
value: Perfusion of livers with a concentration of tBuHQ previously shown to completely inhibit microsomal calcium sequestration in isolated hepatocytes caused a 50% inhibition of protein biosynthesis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2059198

Selventa

RAfGNVlwSaH3ITXrLgtNcjgoi6eBMUrXr5g40H97hhzso
has assertion: p(HGNC:THBS1) -> cat(p(HGNC:CD36))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.331+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:THBS1) -> cat(p(HGNC:CD36))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20664056

5
value: Here we show that thrombospondin-1 (TSP-1) prevents cAMP/protein kinase A (PKA) signaling through a CD36-dependent mechanism.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20664056

Selventa

RAfr3kmbbUDDH0pCCRZG22leboZ BMFdh1hYevJtmCnxE
has assertion: cat(p(MGI:Tlr4)) -> cat(p(MGI:Nos2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.351+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(MGI:Tlr4)) -> cat(p(MGI:Nos2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20849883

6
value: Previously, we demonstrated that lipopolysaccharide (LPS, TLR4 ligand)-increased macrophage motility required the participation of Src and FAK, which was inducible nitric oxide synthase (iNOS)-dependent.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20849883

Selventa

RAQwdzwDrxnsgPKRAOUv5JxeOR7fTiwgqYsk8PHVdFToI
has assertion: a(CHEBI:rosiglitazone) -> r(MGI:Lpl)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.365+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:rosiglitazone) -> r(MGI:Lpl)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20953342

3
value: Rosiglitazone treatment of db/db mice elicited significant changes in the expression of a comparable number of genes to that observed between db/+ and the diabetic control db/db reference group // 100mg/kg/day
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20953342

Selventa

RAQTKcNCTcnezfNSSZNYEHHH-XgFHWixiVOX6ObjpnYFk
has assertion: a(CHEBI:rosiglitazone) -> r(MGI:Pcx)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.367+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:rosiglitazone) -> r(MGI:Pcx)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20953342

3
value: Rosiglitazone treatment of db/db mice elicited significant changes in the expression of a comparable number of genes to that observed between db/+ and the diabetic control db/db reference group // 100mg/kg/day
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20953342

Selventa

RAb0 YCCM2yogeLXDe293rYqhP1aKbVYenH1IsnZbuB s
has assertion: a(CHEBI:rosiglitazone) -> r(MGI:Cox7a1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.374+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:rosiglitazone) -> r(MGI:Cox7a1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20953342

3
value: Rosiglitazone treatment of db/db mice elicited significant changes in the expression of a comparable number of genes to that observed between db/+ and the diabetic control db/db reference group // 10mg/kg/day
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20953342

Selventa

RAdLL4-3zIOsZ7O9bP-ukwfUColG4FKxRmHxAUCqWpzlA
has assertion: a(CHEBI:rosiglitazone) -> r(MGI:Fabp4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.378+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:rosiglitazone) -> r(MGI:Fabp4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20953342

3
value: Rosiglitazone treatment of db/db mice elicited significant changes in the expression of a comparable number of genes to that observed between db/+ and the diabetic control db/db reference group // 10mg/kg/day
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20953342

Selventa

RAUjxUBneGICzuqXn8kIYdgE4EcSPbaPLuL4ZLa-KAeo0
has assertion: a(CHEBI:rosiglitazone) -> r(MGI:Lpl)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.380+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:rosiglitazone) -> r(MGI:Lpl)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20953342

3
value: Rosiglitazone treatment of db/db mice elicited significant changes in the expression of a comparable number of genes to that observed between db/+ and the diabetic control db/db reference group // 10mg/kg/day
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20953342

Selventa

RAfjPD4RXut0DgG2KQIOmnTqZfNIN53nf61YnWNlrhPdM
has assertion: a(CHEBI:rosiglitazone) -> r(MGI:Idh3b)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.394+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:rosiglitazone) -> r(MGI:Idh3b)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20953342

3
value: Rosiglitazone treatment of db/db mice elicited significant changes in the expression of a comparable number of genes to that observed between db/+ and the diabetic control db/db reference group // 30mg/kg/day
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20953342

Selventa

RATw54 O5 SHyLHSj0IN5y5cWURzPSxaCTTkps8mdxa44
has assertion: bp(GO:"response to starvation") -> bp(GO:autophagy)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.409+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to starvation") -> bp(GO:autophagy)
label: p(HGNC:EIF2A,pmod(P,S,51)) -> (bp(GO:"response to starvation") -> bp(GO:autophagy))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20965422

4
value: Cells that carry a non-phosphorylatable mutant of eIF2alpha (S51A) fail to induce autophagy in response to starvation, suggesting that eIF2alpha phosphorylation on serine 51 (and by extension eIF2alpha kinases) plays a major role in autophagy regulation (Kouroku et al., 2007; Talloczy et al., 2002).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20965422

Selventa

RAdC8cWI7rkz0pPoxfjogpAlzC3SW24NFC6sFZ2PadMZg
has assertion: bp(GO:"response to endoplasmic reticulum stress") -> kin(p(HGNC:EIF2AK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.422+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to endoplasmic reticulum stress") -> kin(p(HGNC:EIF2AK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/20965422

4
value: Yeast GCN2 and mammalian PKR and PERK have been shown to be required for autophagy induced by starvation, viral infection, and ER stress, respectively (He and Klionsky, 2009).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/20965422

Selventa

RAckdCuSyy6NpBM809082Bmej qYEoPmpBEWyGXb9dPqI
has assertion: p(EGID:653509) -> r(HGNC:IFNA1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.429+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:653509) -> r(HGNC:IFNA1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2106332

4
value: Treatment for 3 days with IFN-gamma alone, dexamethasone alone, and IFN plus dexamethasone increased the content of surfactant protein A (SP-A, 28 to 36 kD) by approximately 3-, 2.5-, and 10-fold, respectively.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2106332

Selventa

RATSHKMWBpyBAMtaY-PO0BUJznqZixByfkEE1x1flePGQ
has assertion: p(HGNC:IFNG) -> sec(p(HGNC:LYZ))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.430+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IFNG) -> sec(p(HGNC:LYZ))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2107146

5
value: The overall secretion of this peptide by populations of freshly isolated or 3-day cultured monocytes was augmented by exposure for 6 hr to bacterial LPS, recombinant human IFN-gamma or recombinant human TNF alpha
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2107146

Selventa

RAZItjfH1y0TI8cCLFHMSrPGOPiR o1BS1KOD6AUjRaPg
has assertion: p(HGNC:TNF) -> sec(p(HGNC:LYZ))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.431+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> sec(p(HGNC:LYZ))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2107146

5
value: The overall secretion of this peptide by populations of freshly isolated or 3-day cultured monocytes was augmented by exposure for 6 hr to bacterial LPS, recombinant human IFN-gamma or recombinant human TNF alpha
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2107146

Selventa

RAW4twnnCvZnVFT0gsrV47Luk oIA1zVmMoc9wyn9BvT0
has assertion: a(CHEBI:lipopolysaccharide) -| r(HGNC:C4A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.434+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -| r(HGNC:C4A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2107212

3
value: LPS decreases monocyte C4 expression and completely abrogates the effect of IFN-gamma on the expression of this gene.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2107212

Selventa

RAQT1GTQwYbFJZ9m83-biTVISXj1AVM3XbH3KIjpGe3dY
has assertion: p(MGI:Il10) -> kin(complex(NCM:"p85/p110 PI3Kinase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.437+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Il10) -> kin(complex(NCM:"p85/p110 PI3Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21095008

4
value: IL-10 activates the class I phosphatidylinositol 3-kinase (PI3K) pathway, which results in the phosphorylation of p70S6K through the activation of Akt and a mammalian target of the rapamycin complex 1 (mTORC 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21095008

Selventa

RAVEWolzVdbKTanFNL2KsHPqaAAG5Mz9ESzRDZWAgKQuU
has assertion: cat(p(HGNC:TICAM1)) -> tscript(p(HGNC:IRF3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.439+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:TICAM1)) -> tscript(p(HGNC:IRF3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21108806

6
value: while TRAM recruits TRIF to TLR4 for activation of IRF3.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21108806

Selventa

RARNa9pt-9jEXvLC-ZCIoAtbMUBwzQXuwB1-6lNv5rgtY
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> p(HGNC:AKT1,pmod(P,S,473))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.442+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> p(HGNC:AKT1,pmod(P,S,473))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21131356

4
value: FIGURE 3. Amino acids induce Akt phosphorylations (Thr-308,Ser-473) via class I PI3K
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21131356

Selventa

RAb1wYyPB0FRTXXlm7pmko07yvWFVtuBwR9D89hcsqDPc
has assertion: p(HGNC:PML) -> tscript(p(HGNC:TP53))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.443+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PML) -> tscript(p(HGNC:TP53))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21205865

5
value: Here, we show that the mechanism by which PML induces a permanent cell cycle exit and activates p53 and senescence involves a recruitment of E2F transcription factors bound to their promoters and the retinoblastoma (Rb) proteins to PML nuclear bodies enriched in heterochromatin proteins and protein phosphatase 1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21205865

Selventa

RAZAIHaAnnhby7kXv3k9VupMehLebHqsVrgTaLQe1K0Tk
has assertion: kin(p(HGNC:MAPK3)) -> tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.464+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK3)) -> tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21325823

5
value: These demonstrate that Ang II is capable of inducing CRP generation in macrophages via AT(1)-ROS-ERK1/2/p38MAPK-NF-kB signal pathway, which contributes to better understanding of the proinflammatory and proatherosclerotic actions of Ang II.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21325823

Selventa

RAbc-GTxhvWGMjk89Fn28Tq3Bl-y2EU34HoE2xLBUq1bc
has assertion: a(CHEBI:"reactive oxygen species") -> p(HGNC:HRAS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.465+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -> p(HGNC:HRAS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21362163

3
value: Recent evidence has correlated skin fibrosis in SSc with stabilization of proto-oncogene Ha-Ras secondary to auto-antibody stimulation of reactive oxygen species production.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21362163

Selventa

RAUQUOQIjTD2qD rHz7qOpGSTL Kx2ax5l-RlKKpgrVj4
has assertion: p(HGNC:BCL2L11) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.466+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:BCL2L11) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21373644

3
value: Here, we show that RhoB activity increases in human breast and cervical cancer cell lines after treatment with DNA damaging agents. Furthermore, RhoB activity is necessary for DNA damage-induced cell death, as the stable loss of RhoB protein expression using shRNA partially protects cells and prevents the phosphorylation of c-Jun N-terminal kinases (JNKs) and the induction of the pro-apoptotic protein Bim after IR.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21373644

Selventa

RAUgXUjsgdnL234vhpihtcHEOe8bqPGumnXtZoVRI55vk
has assertion: p(MGI:Tnf) -> surf(p(MGI:Vcam1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.472+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Tnf) -> surf(p(MGI:Vcam1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21378027

5
value: Wild-type and TNF receptor knockout mice were treated with intravenous (iv) TNF, and the surface expression of leukocyte adhesion molecules VCAM-1, E-selectin, and ICAM-1 was quantitatively assessed on PECs by flow cytometry...E-selectin showed peak expression on PECs at 2 h after TNF treatment, while VCAM-1 and ICAM-1 expression was greater at 4 h
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21378027

Selventa

RAZcz3WEaywqkIq5vflh9ow2fsvPTvqFmtPaLAScI vNM
has assertion: a(CHEBI:lipopolysaccharide) -> p(HGNC:CFB)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.479+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> p(HGNC:CFB)
label: p(HGNC:IL4) -| (a(CHEBI:lipopolysaccharide) -> p(HGNC:CFB))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2141041

5
value: IL-4 also abrogated the effects of IL-1 and LPS on factor B synthesis, but did not affect the increase in synthesis of factor B induced by IFN-gamma.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2141041

Selventa

RAXIK7vHFHHt6t7iUcRgNAPZvPeJIZ-Sf3wRL3E5gdsiE
has assertion: p(HGNC:TNF) -> p(HGNC:C3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.484+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> p(HGNC:C3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2141041

4
value: In contrast to the pattern for effect of IL-4 on factor B synthesis, the TNF-induced rate of synthesis of C3 was augmented by IL-4.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2141041

Selventa

RAXHPYuw8Yt1zU3c-WjEXRb4a1sHx4snHyko7igsk5eUo
has assertion: p(HGNC:IL4) -| (p(HGNC:TNF) -> p(HGNC:CFB))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.487+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL4) -| (p(HGNC:TNF) -> p(HGNC:CFB))
label: p(HGNC:TNF) -> p(HGNC:CFB)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2141041

6
value: TNF increased synthesis of factor B by 18.6-fold; IL-4 reduced the TNF effect on factor B synthesis by 83%.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2141041

Selventa

RASdjjZXqnuTgdjpDJ8bfjwoNmWL6EgEbmpzC3GQLJd-Q
has assertion: p(HGNC:THBS1) -> p(HGNC:TGFB1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.538+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:THBS1) -> p(HGNC:TGFB1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21453480

4
value: Thrombospondin 1 (TSP1), an activator of latent transforming growth factor (TGF)-B, is overexpressed by scleroderma fibroblasts.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21453480

Selventa

RARz5D25mrQLwRrDkrihcPPM8mqwIBDQHLLYjaxJGgBI8
has assertion: a(CHEBI:"amino acid") -> (gtp(p(HGNC:RHEB)) -> kin(p(EGID:2475)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.548+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"amino acid") -> (gtp(p(HGNC:RHEB)) -> kin(p(EGID:2475)))
label: gtp(p(HGNC:RHEB)) -> kin(p(EGID:2475))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21512002

7
value: In mammalian cells, in response to AAs, the Rag GTPase complex recruits mTORC1 to lysosomes, where mTOR is activated by Rheb.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21512002

Selventa

RAYIqFmZ4N-uMPngTdv16Awz3WK6hokn6N1191yqvs NY
has assertion: p(HGNC:TGFB1) -> tscript(p(HGNC:SMAD4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.552+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TGFB1) -> tscript(p(HGNC:SMAD4))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21515915

5
value: The expression of JunD colocalised with pSmad 3 in fibrotic skin and silencing of Smad 3 or Smad 4 by siRNA prevented the induction of JunD by TGFbeta......The expression of JunD was analysed by real-time PCR, immunofluorescence, western blotting and immunohistochemistry.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21515915

Selventa

RAajvdBbaKZnQ50Y6X6MqaJqU RAKP5Afz6XEHPpAmDrs
has assertion: p(RGD:Ngf) -> p(EGID:29549)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.554+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ngf) -> p(EGID:29549)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2155237

4
value: PC-12 cells treated with 4 nM of NGF for 5 minutes exhibited rapid increase in Microtubule associated protein kinase (MAP kinase) activity, reaching a maximum at 5-10 minutes and declined by 20-25 minutes which was followed by a second phase of ac compared to control cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2155237

Selventa

RAaYCz65im6CiR8Xyom1GehmZLJdfFUWiaTN8LLCbe5x0
has assertion: a(SCHEM:"Concanavalin A") -| r(MGI:Tubb2a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.560+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Concanavalin A") -| r(MGI:Tubb2a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2157431

3
value: The increase in beta-tubulin mRNA expression which was observed after cell culture and after stimulation by dB-cAMP was suppressed by the addition of Con A.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2157431

Selventa

RARx2emJmRhBhBORHrkaZSSOUD-4PaZWLvVPM-qoPjR2M
has assertion: kin(p(PFH:"PRKC Family")) -> r(HGNC:PLAT)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.569+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> r(HGNC:PLAT)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2167321

5
value: t-PA expression is modulated by PMA on the level of transcription. the PMA-mediated induction
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2167321

Selventa

RAcgCzntSgr5Yk1cGbV5h1VjHy4N8GTE7ZWkCYI9i9KvE
has assertion: gtp(p(HGNC:RHEB)) -> kin(p(EGID:2475))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.573+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:RHEB)) -> kin(p(EGID:2475))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21709535

6
value: Class I PI3K, a heterodimer consisting of a regulatory and a catalytic subunit, is a negative regulator of autophagy that is activated by the insulin receptor and the insulin receptor substrate proteins. Activated class I PI3K mainly uses PtdIns(4,5)P2 as substrate to yield PtdIns(3,4,5)P3 at the plasma membrane, which increases membrane recruitment of both PKB/Akt and its activator phosphoinositide- dependent protein kinase 1, leading to the activation of PKB/Akt, a downstream negative regulator of autophagy. Activated PKB/Akt further activates mTOR through inhibiting a downstream protein complex, the tuberous sclerosis complex 1/2, that represses the small G protein Rheb, causing inhibition of autophagy.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21709535

Selventa

RAbuu-fBiKNs9Ch8aKXKZCyXozw4LFNGIoLhpGl45cZcA
has assertion: a(SCHEM:Tretinoin) -> r(MGI:Lamp1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.578+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Tretinoin) -> r(MGI:Lamp1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2172246

3
value: beta-all transretinoic acid (RA) resulted in an increased level of two lysosomal-associated membrane glycoproteins (LAMP-1 and LAMP-2)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2172246

Selventa

RAdwlkiynIIetu9KrPR50dO87WMrWDchh75Xh7yIdyilE
has assertion: kin(p(HGNC:EGFR)) => p(HGNC:PLCG1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.589+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:EGFR)) => p(HGNC:PLCG1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2173144

5
value: Phospholipase C gamma 1 (PLC gamma 1) and p21ras guanosine triphosphatase (GTPase) activating protein (GAP) bind to and are phosphorylated by activated growth factor receptors
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2173144

Selventa

RAXEicrq1el7q 2YxLeB8PwCnHzZexhgmR42vKvBZv7VA
has assertion: p(HGNC:IL1B) -> p(HGNC:CSF2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.594+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL1B) -> p(HGNC:CSF2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2174906

4
value: Rheumatoid arthritic synoviocytes were incubated for 48 hours in the medium containing IL-1Beta (100U/ml). IL-1Beta induced GM-CSF production.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2174906

Selventa

RAQCXOf1xsXvXcnKfBu xyzixWnwagI9SPoXL9KhVt5aM
has assertion: a(CHEBI:"reactive oxygen species") -> cat(p(MGI:Parp1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.598+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -> cat(p(MGI:Parp1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21767558

4
value: cadmium generated reactive oxygen species (ROS) at relatively low levels, and caused poly(ADP-ribose) polymerase-1 (PARP) activation and ATP depletion.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21767558

Selventa

RAVX4I9T-9RKA78ntgUYQoidkHPMLl0XNnrtLYzn6bRfE
has assertion: p(HGNC:F2) -> bp(GO:"regulation of vascular permeability")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.617+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:F2) -> bp(GO:"regulation of vascular permeability")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21858121

3
value: Exposure to thrombin induced a redistribution of VE-cadherin into a zigzag wide pattern typical for unstable and activated junctions and the generation of intercellular gaps. Ang-1 preincubation attenuated the effect of thrombin on VE-cadherin redistribution and gap formation. However, still some intercellular gaps were visible in accordance with the thrombin-induced permeability in Ang-1 treated cells (Figure 3c). In contrast, the effect of thrombin was enhanced in Ang-2 treated cells, which resulted in even wider VE-cadherin staining and a stronger zigzag pattern together with more intercellular gaps (Figure 3c).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21858121

Selventa

RAYl8cxpvj8YEJs9ICiQjk-oxlLQeJVJC50MWlBpYZCls
has assertion: a(SCHEM:"serum insulin") -> r(MGI:Gpd1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.623+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> r(MGI:Gpd1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2187890

3
value: During adipose conversion, insulin promotes an accumulation of G3PDH mRNA which is linked to cell differentiation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2187890

Selventa

RAf77KGDVGt4-E8kOkRXptVC4QUzlAWJPs0z6WJt 5gE8
has assertion: p(HGNC:NRAS,sub(Q,61,K)) => gtp(p(HGNC:NRAS))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.633+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: Q,61,K
variant of: http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7989
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(HGNC:NRAS,sub(Q,61,K)) => gtp(p(HGNC:NRAS))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2197591

5
value: From mutations file
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2197591

Selventa

RAfG-x395mpH53O4WtC5rA4yOa64Xbu7lC-jqK-4T6wak
has assertion: p(HGNC:TNF) -> surf(p(HGNC:SELE))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.635+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> surf(p(HGNC:SELE))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/21977310

5
value: Maximal expression was found 4 h and 12 h post-TNF-? stimulation for ESELE and VCAM-1, respectively. ICAM-1 expression stayed high between 8 and 48 h (see Figure 1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/21977310

Selventa

RAYSwh18LmMYWD-IRmc6f5rdwaDCfUa3d-UGl9hXp4w58
has assertion: a(SCHEM:"serum insulin") -> r(MGI:Zfp36)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.639+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> r(MGI:Zfp36)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2204625

3
value: By differential hybridization screening of a cDNA library derived from insulin-stimulated cells, we selected a clone which hybridized to an mRNA species that rapidly accumulated in response to insulin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2204625

Selventa

RAQxRirSGAjdBks8PmTyH-VP-KnKJvgNXxs4Tyb3w1gzM
has assertion: tscript(p(HGNC:MYCN)) -> p(HGNC:STMN1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.644+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:MYCN)) -> p(HGNC:STMN1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2267130

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2267130

Selventa

RAXrgxTW2aInwzZhjFuzlhKqSX3rKoxN2dE8UkUr1lLV0
has assertion: p(HGNC:TNF) -> sec(p(HGNC:CLEC3B))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.650+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> sec(p(HGNC:CLEC3B))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2298916

5
value: Stimulation of intact neutrophils with nanomolar concentrations of FMLP, leukotriene B4, 10-100 U/ml of tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor resulted in parallel release of tetranectin and translocation of alkaline phosphatase to the plasma membrane.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2298916

Selventa

RAYNOTeFl204KtPMpIe-FZ-bp6gUUtg7ZdrLO-Ge0ItqA
has assertion: p(HGNC:TGFB1) -| bp(GO:"osteoclast differentiation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.652+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TGFB1) -| bp(GO:"osteoclast differentiation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2326263

3
value: Osteoinductive factor (OIF) is a glycoprotein in bone that induces ectopic bone formation. Implantation of OIF plus transforming growth factor beta (TGF-beta) type 1 or 2 into subcutaneous tissues of rats induces formation of bone at the implantation site. Since TGF-beta is also present in bone matrix and inhibits formation of multinucleated cells that express an osteoclast phenotype in long-term human marrow cultures, we tested the effects of OIF on formation of these osteoclast-like cells to determine the effects of OIF on cells in the osteoclast lineage. We found that OIF inhibited total multinucleated cell (MNC) formation in a dose-dependent fashion and preferentially inhibited formation of MNCs that react with monoclonal antibody 23c6 (23c6-positive MNCs), an antibody that identifies osteoclasts. In addition, low concentrations of OIF in combination with low concentrations of TGF-beta acted synergistically to inhibit 23c6-positive MNC formation. The inhibition of 23c6-positive MNC formation by OIF was not mediated by prostaglandin synthesis. These data suggest that regulatory growth factors, such as OIF or TGF-beta, that are stored within the bone matrix and released when bone is resorbed can serve as natural inhibitors of osteoclast activity by inhibiting osteoclast formation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2326263

Selventa

RAalQsA24a3OHWhmHyGK7524E0PcXUcLK7CjlBZHvhTZo
has assertion: p(HGNC:ALB) -> cat(p(HGNC:FECH))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.658+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ALB) -> cat(p(HGNC:FECH))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2340297

5
value: Human serum albumin, but not bovine serum albumin was able to prevent the inhibition
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2340297

Selventa

RAfgUDkyPdRjwBxRvkOuf3tS-jmADZVcuYRtEqfvagTds
has assertion: kin(p(RGD:Uck2)) -> bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.670+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(RGD:Uck2)) -> bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2430783

4
value: The controversial issue of the effects of prednisolone and 17 beta-estradiol on replication of fetal rat pancreatic islets in culture was studied Further support for a lack of inhibition of growth of islet cells treated with steroid hormones was provided by the observation that prednisolone increased uridine kinase activity and RNA biosynthesis, both of which may participate in the growth of cells preceding mitosis and (the latter) in protein hormone biosynthesis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2430783

Selventa

RAcy0eGX79V6eTHH397WdzSqedJWEig erfNmQVqug3uU
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -| p(HGNC:FGF1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.676+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -| p(HGNC:FGF1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2457532

3
value: At 170 pg/ml, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) caused a 50% inhibition of heparin-binding growth factor type one (HBGF-1)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2457532

Selventa

RAaR3bUqu4YceJrQej6ac5b7GkNn3SLoaMAc08ZdlV-JY
has assertion: p(RGD:Il1b) -> path(SDIS:"systemic acute phase reaction")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.692+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Il1b) -> path(SDIS:"systemic acute phase reaction")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2472096

3
value: the 2 cytokines most intensively involved in eliciting the acute phase response are IL6 and IL1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2472096

Selventa

RASThSxk7YQaxNd-qHOA mcMx76JWEPfLolLWiIBGYCKQ
has assertion: a(CHEBI:glucocorticoid) -| r(HGNC:GAPDH)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.699+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glucocorticoid) -| r(HGNC:GAPDH)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2476083

3
value: Both dexamethasone and 13-cis-RA also reduced the mRNA level of glyceraldehyde-3-phosphate dehydrogenase, indicating that glucocorticoids and retinoids have both similar and different effects on gene expression in HSF
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2476083

Selventa

RAbfWIg7MAXDL-zNGYHMB-jCXOTI1jdAsaCMTtlXtKt7c
has assertion: bp(GO:"response to virus") -> r(HGNC:MX1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.702+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to virus") -> r(HGNC:MX1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2481229

3
value: In human fibroblasts, expression of MxA and MxB is strongly induced by alpha interferon (IFN-alpha), IFN-beta, Newcastle disease virus, and, to a much lesser extent, IFN-gamma
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2481229

Selventa

RAf8bT4jkDsVqzqf C-jhajhuVy5v4pSzsBnM4fyQoe9o
has assertion: p(MGI:Il6) -> p(MGI:Fga)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.705+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Il6) -> p(MGI:Fga)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2483767

4
value: alpha 2-macroglobulin, alpha 1-antichymotrypsin ( = contrapsin), cysteine protease inhibitor ( = thiostatin), alpha 1-antitrypsin, ceruloplasmin and fibrinogens are predominantly regulated by the keratinocyte-derived HSF-III/-II or IL-6
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2483767

Selventa

RAd2rvlrn2tVfzPjHDbdpkaY-zXSf3OCAwGUZ8tERvcM4
has assertion: a(CHEBI:histamine) -> sec(a(SCHEM:Epoprostenol))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.710+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:histamine) -> sec(a(SCHEM:Epoprostenol))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2509221

3
value: The present studies demonstrate that rat aortic endothelial cells, when stimulated with either bradykinin or histamine, caused the release of both PGI2 and PGE2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2509221

Selventa

RAZh-nigdP KukyyU8A DLCyhijuApfld7ikCVrJRgCOg
has assertion: cat(p(MGI:Ank)) -| bp(GO:"inflammatory response")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.716+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(MGI:Ank)) -| bp(GO:"inflammatory response")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2541245

4
value: By light microscopy, the earliest synovial lesion was inflammatory followed by synovial proliferation and cartilage erosions.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2541245

Selventa

RAZFFWm14HgsOdpNlOEUaGeOQlubRgN-FGjzsGcd8fvyA
has assertion: kin(p(PFR:"Prka Family")) -> cat(p(RGD:Lipa))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.724+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFR:"Prka Family")) -> cat(p(RGD:Lipa))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2555647

6
value: rat liver cholesterol ester hydrolase is activated by cyclic AMP dependent protein kinase and protein kinase C. Deactivation is accomplished by dephosphorylation catalyzed by a phosphoprotein phosphatase, dependent on Mg2+.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2555647

Selventa

RAdGpQLBR6G6e- Dtrc5vcNvqRK9XOYajn6lkTuIZned8
has assertion: a(SCHEM:Norepinephrine) -> r(RGD:Fos)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.729+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Norepinephrine) -> r(RGD:Fos)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2572704

3
value: Norepinephrine (NE), isoproterenol, or phenylephrine also induced TIS mRNA accumulation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2572704

Selventa

RAW4zz9xsGGIVtMtQ-6TzFCgE3TqVELkOYcIYLLVhlaxY
has assertion: bp(GO:aging) -> cat(p(RGD:Qprt))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.732+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:aging) -> cat(p(RGD:Qprt))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2578178

4
value: Enzyme activity was present at the earliest age tested, 2 days, and tended to increase in older animals
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2578178

Selventa

RAWWsCWFpA5daR6Xh dsES8h7gxmdvRqy5x3vjEPZzOX8
has assertion: a(CHEBI:estradiol) -| cat(p(HGNC:MDH1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.736+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:estradiol) -| cat(p(HGNC:MDH1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2641819

4
value: Estradiol produced selective inhibitions of glucose synthesis from various substrates and diminished malate dehydrogenase activity by 22%
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2641819

Selventa

RAZXzT84ByUi6Jh-rpWjr9lCvoyFucpCfPvBg4ctub92g
has assertion: kin(p(PFH:"PRKC Family")) -> r(HGNC:TFF1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.744+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> r(HGNC:TFF1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2664475

5
value: pS2 mRNA, but not cathepsin-D mRNA, was also induced up to 8-fold by protein kinase-C activation with 12-O-tetradecanoylphorbol-13-acetate
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2664475

Selventa

RAbTckoVahw3D3r0n6qlsK0XICQ4CMHnVM2ZVlkyP32ZQ
has assertion: kin(p(PFM:"Prkc Family")) -> r(MGI:Zfp36)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.751+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFM:"Prkc Family")) -> r(MGI:Zfp36)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2677677

5
value: When GM-CSF-deprived 32D clone 3 cells were exposed to GM-CSF or to TPA, four TIS mRNAs (TIS7, TIS8, TIS10, and TIS11) were rapidly and transiently induced.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2677677

Selventa

RARsQnzZBAQ4 pJX6-PV-dgD9bsu2bs9xqPR3ZwjxDMnQ
has assertion: a(CHEBI:testosterone) -> r(MGI:Nudt19)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.753+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:testosterone) -> r(MGI:Nudt19)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2710112

3
value: The RP2 gene was found to contain at least two promoters, only one of which was highly sensitive to testosterone.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2710112

Selventa

RAUkO9tLEPvWfkMFS1 SjJNvZmsDL9AP-BiyRWzkxvOB8
has assertion: cat(p(HGNC:F2)) -> bp(GO:"platelet activation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.759+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:F2)) -> bp(GO:"platelet activation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2752154

4
value: Activation of and degranulation of platelets by thrombin treatment caused release of lysosomal enzymes (beta-glucuronidase and N-acetyl-D-glucosaminidase), alpha-granule proteins (beta-thromboglobulin and fibrinogen) as well as mitogenic activity for MCF-7 cells and IGF-I as measured by radioimmunoassay (RIA) and radioreceptor assay.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2752154

Selventa

RAaGvzze6iNIy9Pv46t-3-hatoPK7QlMwWwJ7HVQRtnSc
has assertion: cat(p(HGNC:F2)) -> sec(p(HGNC:NAGLU))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.762+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:F2)) -> sec(p(HGNC:NAGLU))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2752154

6
value: Activation of and degranulation of platelets by thrombin treatment caused release of lysosomal enzymes (beta-glucuronidase and N-acetyl-D-glucosaminidase), alpha-granule proteins (beta-thromboglobulin and fibrinogen) as well as mitogenic activity for MCF-7 cells and IGF-I as measured by radioimmunoassay (RIA) and radioreceptor assay.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2752154

Selventa

RAZyspdgfXhBbWWE3G5LTm7baaVRM1QXSZI6agR6ru2wI
has assertion: cat(p(HGNC:F2)) -> sec(p(HGNC:PPBP))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.764+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:F2)) -> sec(p(HGNC:PPBP))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2752154

6
value: Activation of and degranulation of platelets by thrombin treatment caused release of lysosomal enzymes (beta-glucuronidase and N-acetyl-D-glucosaminidase), alpha-granule proteins (beta-thromboglobulin and fibrinogen) as well as mitogenic activity for MCF-7 cells and IGF-I as measured by radioimmunoassay (RIA) and radioreceptor assay.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2752154

Selventa

RAeYArqjbq17p4Jxx2xJSazIanV2 2DWk8s5ls aQ9d98
has assertion: cat(p(HGNC:SULT1E1)) -| p(HGNC:ESR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.767+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:SULT1E1)) -| p(HGNC:ESR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2755123

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2755123

Selventa

RAYxtd7U3uZmz5Ej82iC-5fJQV1spVI-5DZt8ArPA6E84
has assertion: bp(GO:"response to starvation") -| p(RGD:Pfkfb1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.783+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to starvation") -| p(RGD:Pfkfb1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2848802

3
value: Both enzymatic activities fell to 20% of control values with fasting or streptozotocin-induced diabetes and were coordinately restored to normal within 48 h of refeeding or 24 h of insulin administration. These alterations in enzymatic activities were always mirrored by corresponding changes in amount of enzyme
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2848802

Selventa

RAZ2hGhUJJQgInBnEEJCcWplc4B30NMPB4PLiLUdTZpCg
has assertion: bp(GO:"response to starvation") -| kin(p(RGD:Pfkfb1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.785+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to starvation") -| kin(p(RGD:Pfkfb1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2848802

4
value: Both enzymatic activities fell to 20% of control values with fasting or streptozotocin-induced diabetes and were coordinately restored to normal within 48 h of refeeding or 24 h of insulin administration. These alterations in enzymatic activities were always mirrored by corresponding changes in amount of enzyme
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2848802

Selventa

RAXn2LBXhmMYqlBgScW3RUCKpTDbNdsYKx6Pv3c5Gw BA
has assertion: p(HGNC:ANXA2) -| cat(p(PFH:"PLA2 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.797+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ANXA2) -| cat(p(PFH:"PLA2 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2953722

5
value: phosphorylation of lipocortin has been shown to block its inhibitory activity
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2953722

Selventa

RAZRbYeuQhFSo9ReuPuMTtMusGxZWe-30BBTKwWSPsw0A
has assertion: p(RGD:Ar) -| cat(p(RGD:Akr1c1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.809+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ar) -| cat(p(RGD:Akr1c1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/2994767

5
value: Effects comparable to that induced by testosterone were elicited by other androgens (androstenedione and 5 alpha-dihydrotestosterone)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/2994767

Selventa

RAQwYATbcZBvpPcDQx nMKkCm0jTSc BQw-Y3Xxo7gjXk
has assertion: a(CHEBI:lipopolysaccharide) -> p(HGNC:CFB)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.814+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> p(HGNC:CFB)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3003195

3
value: In contrast, adult monocytes increased C3 synthesis by 11.5-fold and factor B synthesis by 3.1-fold in response to LPS.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3003195

Selventa

RATOtRk0m ZyR-zzpTroW-PkBTFVRRtkXwsLDqyOUu g8
has assertion: a(SCHEM:Calcium) -> cat(p(RGD:Alox5))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.821+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> cat(p(RGD:Alox5))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3012653

4
value: The 5-lipoxygenase activity is stimulated by Ca++ and ATP
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3012653

Selventa

RAYJi6bl1 SqTaFhL 6Pex03KqenJe4HpO zpNcovJSQc
has assertion: p(HGNC:ANXA2) -| cat(p(PFH:"PLA2 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.822+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ANXA2) -| cat(p(PFH:"PLA2 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3013422

5
value: We have purified two 35 kd phospholipase A2 inhibitors from human placenta, which we refer to as lipocortin I and II.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3013422

Selventa

RAaEGsz17KnnMT85XK05S-7eMWcrWMht6yU3TtnSBI3lk
has assertion: kin(p(HGNC:EGFR)) => p(HGNC:ENO1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.828+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:EGFR)) => p(HGNC:ENO1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3030270

5
value: Here we show that purified EGF (epidermal growth factor)-receptor kinase phosphorylates the enzymes PGM and enolase and also the key regulatory enzymes of the glycolytic pathway, phosphofructokinase and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), in an EGF-dependent manner. (From Results: Tyrosine is the only amino acid in these enzyme substrates that was phosphorylated by purified EGFreceptor kinase (Fig. 2).)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3030270

Selventa

RASgrd0pZnXOsGel0NVMduccfa68NhKG7tkDW5kUXaUfs
has assertion: p(HGNC:KRAS,sub(G,12,V)) => gtp(p(HGNC:KRAS))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.831+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: G,12,V
variant of: http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6407
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(HGNC:KRAS,sub(G,12,V)) => gtp(p(HGNC:KRAS))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3047672

5
value: From mutations file
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3047672

Selventa

RAaAo7wO--C0gfDQDe8IdhP5kJme4J4XsY DRiwuZU0yY
has assertion: p(HGNC:IL1A) -> sec(a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.834+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL1A) -> sec(a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine"))
label: p(HGNC:SERPINA3) -| (p(HGNC:IL1A) -> sec(a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine")))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3049910

6
value: Both antiproteinases also inhibited PAF production stimulated by phagocytosis in macrophages and induced with IL-1 in neutrophils or with TNF in vascular endothelial cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3049910

Selventa

RAetw W-RcMKBsnFwMHVCaArw1s5JUOSVmuBGrPSQdr88
has assertion: p(HGNC:IL1A) -> sec(a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.841+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL1A) -> sec(a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3049910

4
value: TNF and IL-1 stimulate the synthesis and release of platelet-activating factor (PAF) by neutrophils and vascular endothelial cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3049910

Selventa

RAVqHUkoLpQzGWr23DnM3ZRBbpCMHG6P2IgXA6kZfTRNo
has assertion: p(HGNC:TNF) -> sec(a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.844+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> sec(a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3049910

4
value: TNF and IL-1 stimulate the synthesis and release of platelet-activating factor (PAF) by neutrophils and vascular endothelial cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3049910

Selventa

RAYm3Jy00q2m1-gpluMfwMSAxxxmVUJbaIrf0-3ACC9ik
has assertion: a(CHEBI:androgen) -> r(MGI:Gusb)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.852+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:androgen) -> r(MGI:Gusb)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3071998

3
value: Androgen controls the expression of beta-glucuronidase and several other proteins in the kidney of the standard laboratory mouse, Mus musculus.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3071998

Selventa

RAWSLpLbrFLJYW2Icn1rjkhh0GKgJ3Gn1mRpJJ1lSmwIQ
has assertion: a(CHEBI:glucocorticoid) -> cat(p(RGD:Got1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.860+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glucocorticoid) -> cat(p(RGD:Got1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3182856

4
value: Glucocorticoid hormones increased the activity of cytosolic but not mitochondrial aspartate aminotransferase in both liver and kidney. The increase in the enzyme activity was accompanied by an increase in the amount of the three corresponding mRNAs, while the mitochondrial enzyme mRNA was not significantly modified.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3182856

Selventa

RAcfaeTZYe3HOZKOXynMSU0ftxVXvnTEp7V-p sUsTH9k
has assertion: p(HGNC:KRAS,sub(G,13,D)) => gtp(p(HGNC:KRAS))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.891+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: G,13,D
variant of: http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6407
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(HGNC:KRAS,sub(G,13,D)) => gtp(p(HGNC:KRAS))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3627975

5
value: From mutations file
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3627975

Selventa

RAeM0pBfdlAwi0WuCAhDEu0XCPt0vTUic1Nmbud4eVFuc
has assertion: p(RGD:Ngf) -> r(RGD:Tuba1a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.893+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ngf) -> r(RGD:Tuba1a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3693406

4
value: Expression of T alpha 1 mRNA is also increased in PC12 cells induced to differentiate and extend neurite processes by nerve growth factor.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3693406

Selventa

RAaxe-XeMfWr0oHREGgLC1oV3t3MUCDD x2N1rZTuHYI0
has assertion: bp(GO:"neuron differentiation") -> r(RGD:Tuba1a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.894+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"neuron differentiation") -> r(RGD:Tuba1a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3693406

3
value: Expression of T alpha 1 mRNA is also increased in PC12 cells induced to differentiate and extend neurite processes by nerve growth factor.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3693406

Selventa

RAe Z0nlZrXm7ZFemyeh-BuHFTGp 6Xjxue6YvU -BGzU
has assertion: bp(GO:"cell proliferation") negativeCorrelation r(HGNC:COL1A1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.896+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"cell proliferation") negativeCorrelation r(HGNC:COL1A1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3754462

3
value: Analyses of populations of dividing and nondividing human lung fibroblasts revealed that, on a per cell basis, the nondividing population contained twice as much alpha 1(III) mRNA than did the dividing population. The same was true for the type I collagen alpha 1(I) and alpha 2(I) mRNA
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3754462

Selventa

RAb-VyyYOG6R6f9drUcp9kpqnyZ0vvWMUjc2ZKjtMK-TE
has assertion: a(SCHEM:Epinephrine) -| r(RGD:Alb)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.904+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Epinephrine) -| r(RGD:Alb)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3782147

3
value: Conversely, epinephrine suppressed stimulation of expression of the albumin gene by dexamethasone.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3782147

Selventa

RASywRHn Auu1zrTD8 NvTYJzDQAh4RnMTTnx uFzvOI4
has assertion: bp(GO:"response to hypoxia") -> r(HGNC:UGDH)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.907+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -> r(HGNC:UGDH)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3804697

3
value: Entrez Gene summary: Human: The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3804697

Selventa

RAdS4TbD-rG7RdscbroOwsRgQjOSB w8PbMnomBE3Z9L0
has assertion: p(RGD:Egf) -> p(PFR:"Act Family")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.913+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Egf) -> p(PFR:"Act Family")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3873645

4
value: We have isolated cloned cDNAs corresponding to five mRNAs whose level is increased following stimulation of quiescent rat fibroblasts by either epidermal growth factor or serum lactate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase, enolase, triose phosphate isomerase, and actin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3873645

Selventa

RAV2NcOGcaoZa3Wenb67RcsTXi-gD LcFvDj-2bhdYyv8
has assertion: kin(p(HGNC:INSR)) => p(HGNC:TUBA4A,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.918+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:INSR)) => p(HGNC:TUBA4A,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3920212

5
value: The purified insulin receptor kinase catalyzed the phosphorylation of native tubulin and microtubule-associated proteins (MAPs; MAP2, tau) on tyrosine residues. Insulin (10(-7) M) stimulated the reaction by 4-10-fold by increasing Vmax with little change in Km. alpha-Tubulin was preferred as a substrate for the kinase compared to beta-tubulin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3920212

Selventa

RAfB5A8uyUEGHGS5AJowGb8UYbx-k67Imbtb-BaVQ7n9E
has assertion: a(SCHEM:Tunicamycin) -| p(HGNC:AIP)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.920+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Tunicamycin) -| p(HGNC:AIP)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3929614

3
value: Tunicamycin (a specific inhibitor of N-linked glycosylation) inhibited aldosterone-stimulated Na+ transport and AIP synthesis without affecting overall protein synthesis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3929614

Selventa

RAdjL1WE0tS248uTPyl3-1 SqEQDQzvdmqscI2X4MEaYc
has assertion: a(SCHEM:Dinoprostone) -> kin(p(RGD:Ckb))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.922+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Dinoprostone) -> kin(p(RGD:Ckb))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3937588

4
value: We have previously shown that both parathyroid hormone (PTH) and prostaglandin E2 (PGE2) stimulate the activity of creatine kinase BB (CKBB) in rat bone cells in culture.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3937588

Selventa

RAdHqotwkKqAerseiVmARbAjE8PJu20Ee3XdInHkAogDQ
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Ctsl)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.925+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Ctsl)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/3990681

3
value: The major excreted protein of transformed mouse fibroblasts, a secreted, mannose 6-phosphate-containing glycoprotein, is induced in nontransformed cells by a variety of transforming agents, by phorbol esters, and by platelet-derived growth factor.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/3990681

Selventa

RAZ7ZWyYuVNQdNbZvrnl4ciVaQdnmOwdvMNYaqNd8mElM
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> p(EGID:641050)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.932+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> p(EGID:641050)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/6092699

3
value: cDNA libraries from EL-4 cells treated with 12-O-tetradecanoyl phorbol-13-acetate (TPA) were screened for TPA-inducible sequences by differential hybridization. The most abundant inducible species was a sequence similar to that of mouse mammary tumor virus (MMTV). Induction of the mRNA corresponding to the MMTV-related sequences was already evident 30 min after TPA treatment, whereas the maximum accumulation occurred after 20 h of exposure to TPA. TPA also increased levels of MMTV-related RNA in the normal spleen cells of BALB/c and C57BL/6 mice.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/6092699

Selventa

RAQnPa2fj0h3PtKBzCKfmqzZ2AoyOVlL2yxIMdSlZKRsI
has assertion: p(HGNC:SERPINA1) -> bp(GO:"cell migration")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.933+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:SERPINA1) -> bp(GO:"cell migration")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/6154015

3
value: In contrast, alpha 2-macroglobulin and alpha 1-antitrypsin enhance leukocyte migration at doses close to physiological serum levels and affect cells irreversibly.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/6154015

Selventa

RAflaKoC4S LgIjj8tyof-Sg235oOHZpieJW8I5iTGolw
has assertion: p(HGNC:IDO1) -| r(HGNC:PTGIS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.945+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IDO1) -| r(HGNC:PTGIS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/6393975

4
value: The synthesis of PGI2-LS was inhibited by Indo in both experiments in a time dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/6393975

Selventa

RATqlzcjGXPfn6BqxFYDzNxs R36 gMMKqWQbb9EuWk8I
has assertion: a(SCHEM:Hydrocortisone) -> r(HGNC:AGT)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.949+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Hydrocortisone) -> r(HGNC:AGT)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/6469271

3
value: Hydrocortisone increased the angiotensinogen synthesis in a dose-dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/6469271

Selventa

RAVD3MIGpZnh8zUqXyODOjyu1hsJdp1dTW0hrJgyO4-xs
has assertion: p(HGNC:KLKB1) -> cat(p(HGNC:PLAT))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.951+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:KLKB1) -> cat(p(HGNC:PLAT))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/6566616

5
value: Tissue kallikrein and factor Xa were found to activate tissue plasminogen activator (t-PA) at a rate comparable with that of plasmin. During the activation reaction, the single-chain molecule was converted into a two-chain form. A slight t-PA activating activity was also found in plasma kallikrein. Other activated coagulation factors, factor XIIa, factor XIa, factor IXa, factor VIIa, thrombin and activated protein C had no effect on t-PA activation. t-PA was also activated by a tissue kallikrein-like enzyme that was isolated from the culture medium of melanoma cells. These results indicate that tissue kallikrein and factor Xa may participate in the extrinsic pathway of human fibrinolysis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/6566616

Selventa

RATVsWZNKzpjyhaOGfQxHpwte8KX0Ihd2NoYnoaxpbfLk
has assertion: a(SCHEM:Dinoprostone) -> bp(GO:"erythrocyte differentiation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.952+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Dinoprostone) -> bp(GO:"erythrocyte differentiation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/6579847

2
value: Prostaglandins E2 (PGE2) and D2 (PGD2), both of which have been demonstrated to be produced in the bone marrow, were found in the present studies to increase the number of CFU-E colonies in normal mouse bone marrow cultures.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/6579847

Selventa

RAVzwlTZ- 1p8bvKr87RQW6hTWRwxLp3AIlUzOvba8u 8
has assertion: a(CHEBI:"prostaglandin D2") -> bp(GO:"erythrocyte differentiation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.953+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"prostaglandin D2") -> bp(GO:"erythrocyte differentiation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/6579847

2
value: Prostaglandins E2 (PGE2) and D2 (PGD2), both of which have been demonstrated to be produced in the bone marrow, were found in the present studies to increase the number of CFU-E colonies in normal mouse bone marrow cultures.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/6579847

Selventa

RATx2GnoRoJdvzhKh0FOBpd5F6uokX7Zb1RhHDOfH02l4
has assertion: cat(p(HGNC:ABR)) -> gtp(p(HGNC:CDC42))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.970+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:ABR)) -> gtp(p(HGNC:CDC42))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7479768

6
value: The Dbl-homology domains of Bcr and Abr were active in stimulating GTP binding to CDC42Hs, RhoA, Rac1, and Rac2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7479768

Selventa

RAQkMKRrTr7PtKZbDrCrb07eVl1k3TI7WOnvU3h9i5xhk
has assertion: cat(p(HGNC:ABR)) -> gtp(p(HGNC:RAC1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.971+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:ABR)) -> gtp(p(HGNC:RAC1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7479768

6
value: The Dbl-homology domains of Bcr and Abr were active in stimulating GTP binding to CDC42Hs, RhoA, Rac1, and Rac2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7479768

Selventa

RAeFBC4nSVLWlnXhbnGtmkIFDXqGq27JSSB91UxHDm9dU
has assertion: cat(p(HGNC:BCR)) -> gtp(p(HGNC:RAC1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:55.974+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:BCR)) -> gtp(p(HGNC:RAC1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7479768

6
value: The Dbl-homology domains of Bcr and Abr were active in stimulating GTP binding to CDC42Hs, RhoA, Rac1, and Rac2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7479768

Selventa

RAWOSvI8M4f0TyNNOWEox773cz1Z0Yq27Y3BFCBwTuBnw
has assertion: tscript(p(HGNC:NR3C1)) -> cat(p(HGNC:SOAT1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.031+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:NR3C1)) -> cat(p(HGNC:SOAT1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7485476

6
value: Dexamethasone produced a 60% increase in activity of the enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT), active in synthesis of cholesteryl esters, and a 40% decrease in that of neutral cholesteryl esterase, active in cholesteryl ester breakdown.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7485476

Selventa

RAYQ5BATTjSrLNk3L6sT XY01f2 kucyUjIQkDv-C5CJU
has assertion: p(MGI:Sod2) -> cat(complex(NCM:"Respiratory Chain Complex II"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.044+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Sod2) -> cat(complex(NCM:"Respiratory Chain Complex II"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7493016

4
value: Cytochemical analysis revealed a severe reduction in succinate dehydrogenase (complex II; 600857) and aconitase (a tricarboxylic acid cycle enzyme; 100850) activities in the heart and to a lesser extent in other organs.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7493016

Selventa

RAfbmZ6TB0pxxQW6 AQ8 nQjJIwAUxucAtK-fyjbwl52E
has assertion: p(MGI:Sod2) -| a(CHEBI:lipid)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.049+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Sod2) -| a(CHEBI:lipid)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7493016

3
value: Homozygous SOD2 -/- mice die within the first 10 days of life with a dilated cardiomyopathy, accumulation of lipid in liver and skeletal muscle, and metabolic acidosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7493016

Selventa

RAbajVDzQQ9ZtH2M3l 5Ij UE4hqd4A3drg8jeYZGukGI
has assertion: p(HGNC:IGF1R,pmod(P,Y,1136)) -> bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.053+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IGF1R,pmod(P,Y,1136)) -> bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7493944

3
value: In addition, they were unable to respond to IGF-I-stimulated cell growth in culture, and tumor formation in nude mice was abrogated.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7493944

Selventa

RAZJaft2SxBgrDp5X9nAoR 9pmfmYn7ESVG-i1WMcdNDQ
has assertion: tscript(p(HGNC:RFX5)) -> r(HGNC:"HLA-DMA")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.056+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:RFX5)) -> r(HGNC:"HLA-DMA")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7495736

5
value: We report here that CIITA and RFX5, although operating at different levels of transcriptional control, are also both essential regulators of HLA-DMA and -DMB genes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7495736

Selventa

RAZKNujNLh70rwdZPTSPEHKg0ahrE4R3AzzMJFLifi Cw
has assertion: cat(p(HGNC:A2M)) -| kin(p(HGNC:NTRK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.073+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:A2M)) -| kin(p(HGNC:NTRK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7508936

6
value: Both 5HT-alpha 2M and MA-alpha 2M also dose dependently block NGF-promoted autophosphorylation of trk in vivo, whereas normal alpha 2M and plasmin-reacted alpha 2M are inactive or much less active. MA-alpha 2M also blocks NGF-promoted incorporation of 32P from [32P]ATP into trk receptors in vitro.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7508936

Selventa

RAdXLupVOFXz k-wG0cNlUnO90frv3SQPAm FgTMQKgAA
has assertion: p(HGNC:FGF2) -> kin(p(PFH:"PRKC Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.076+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:FGF2) -> kin(p(PFH:"PRKC Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7510705

5
value: Activation of the activity of FGF receptor tyrosine kinase in smooth muscle cells by ligand binding resulted in tyrosine phosphorylation of one of the FGF receptors and a 90-kDa-protein as well as increased tyrosine phosphorylation of phospholipase C-gamma. Parallel observations were made in that increased PKC and protein kinase A activities occurred with bFGF as compared with control cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7510705

Selventa

RAVAgeMA76-CT5vnP68Y Y8yGMAWyPcdggv-1o898H89k
has assertion: a(CHEBI:ranitidine) -| cat(p(HGNC:HRH2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.082+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:ranitidine) -| cat(p(HGNC:HRH2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7511596

4
value: Histamine alone did not induce protein synthesis or mRNA accumulation for IL-6. Histamine (1-100 microM) enhanced IL-1 alpha-induced synthesis of IL-6 (p < 0.001). Cimetidine and ranitidine, H2 receptor antagonists structurally unrelated to each other, completely reversed the histamine-mediated increase in IL-1 alpha-induced IL-6 synthesis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7511596

Selventa

RAXeEcszjTvq0Sh8 3ynkVwlf12e1gHUSUqfrQdqz2Hy4
has assertion: p(MGI:Arhgdib) =| gtp(p(MGI:Rac1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.085+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Arhgdib) =| gtp(p(MGI:Rac1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7512369

5
value: Functional studies with the human D4 protein demonstrate that D4 has GDI activity against the CDC42Hs and rac I proteins,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7512369

Selventa

RAfQXHGs6AZtx2ZpflQ PbKNsTWpiz3pH5vlw8G-vhKgA
has assertion: p(HGNC:NGF) -> r(HGNC:TAC1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.092+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:TAC1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7513836

4
value: We found that the temporal pattern of trk expression in DRG neurons correlates with the observed age-dependent ability of nerve growth factor to induce the biosynthesis of the neuropeptide substance P.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7513836

Selventa

RARZKQIaprpF82Yx43SSBDYRu5hmCKzTs5QshhsoB-ReI
has assertion: p(HGNC:IFNG) -> p(HGNC:STAT1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.098+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IFNG) -> p(HGNC:STAT1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7514165

4
value: In this report, we show that binding of IFN-gamma to HeLa cells initiated a series of events that resulted in the extremely rapid (15 s) tyrosine phosphorylation of not only Jak1, Jak2, and p91 but also the IFN-gamma R.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7514165

Selventa

RATpk307IsdvdWXFk53BTyXoaypSFZ9uGaO-6CBV4q9Z8
has assertion: cat(p(HGNC:IFNGR2)) -> kin(p(HGNC:JAK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.100+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:IFNGR2)) -> kin(p(HGNC:JAK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7514165

6
value: In this report, we show that binding of IFN-gamma to HeLa cells initiated a series of events that resulted in the extremely rapid (15 s) tyrosine phosphorylation of not only Jak1, Jak2, and p91 but also the IFN-gamma R.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7514165

Selventa

RAcndVRA3ksECqhrgKWAg-RDd1MvOwe3QY42Tiv5wjm9U
has assertion: p(HGNC:NGF) -> r(HGNC:NPY)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.112+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:NPY)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7522299

4
value: Our results indicate that NGF induces NPY gene expression via activation of PKC system.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7522299

Selventa

RAYG8 7-6BAgJJDd7AEijWzYrx10Ro9hL9Y6j4JkF6s8E
has assertion: a(CHEBI:calcitriol) -> r(MGI:Igfbp4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.119+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:calcitriol) -> r(MGI:Igfbp4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7522842

3
value: Tumor necrosis factor-alpha (TNF-alpha) is a cytokine produced by immune cells, which has multiple effects on bone cells and is therefore thought to mediate changes in bone metabolism occurring during inflammation. In the present study we have investigated the effect of TNF-alpha on the secretion of insulin-like growth factor I (IGF-I) and IGF binding protein 4 (IGFBP-4) by clonal mouse osteoblasts (MC3T3-E1 cells) using subconfluent in vitro cultures and serum-free conditions. The IGF-I was determined by radioimmunoassay under conditions eliminating the interference of IGFBPs. Treatment of MC3T3-E1 cultures with TNF-alpha for 24 h resulted in a dose-dependent decrease in IGF-I secretion (maximally to 34 +/- 9.7% of control with 60 pmol/l TNF-alpha; mean +/- SD). The TNF-alpha treatment also resulted in decreased messenger ribonucleic acid (mRNA) levels of IGF-I at 4 and 24 h, as detected by Northern analysis. Because basal secretion of IGFBPs is very low in MC3T3-E1 cells, effects of TNF-alpha on IGFBP secretion were studied in cultures in which IGFBP-4 expression was increased by calcitriol (1,25(OH)2D3) treatment. The presence of TNF-alpha (600 pmol/l) inhibited this calcitriol-induced stimulation of IGFBP-4 mRNA levels from 4 h onwards, with complete inhibition of the calcitriol effect occurring at 24 h. We also observed a dose-dependent inhibition of calcitriol-stimulated IGFBP-4 secretion into the culture medium (as detected by Western ligand blot), with the maximal inhibition occurring with 600 pmol/l TFN-alpha to 25 +/- 7% of control levels.(ABSTRACT TRUNCATED AT 250 WORDS)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7522842

Selventa

RASKjvhcyKnxqn3CLISbNk7-7aoIGDwayRMb1z8EGBYAM
has assertion: kin(p(HGNC:PDGFRA)) => p(HGNC:PDGFRA,pmod(P,Y,754))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.126+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PDGFRA)) => p(HGNC:PDGFRA,pmod(P,Y,754))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7523122

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7523122

Selventa

RAYxDuZOQtj laBj6cyC4r-Ps1sxw4mXQA4DRZGIJ gOA
has assertion: a(SCHEM:Tretinoin) -> r(HGNC:KRT13)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.128+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Tretinoin) -> r(HGNC:KRT13)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7525098

3
value: As in cultured primary keratinocytes from normal internal stratified epithelia, the in vitro expression of K13 in transformed epidermal cell lines can be induced either by Ca2+ or by retinoic acid (RA).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7525098

Selventa

RARAYqKFRPcv7gCmNMjslkZZswdDEdrWxpxZagfvlNCwM
has assertion: kin(p(PFH:"PRKC Family")) => p(HGNC:DDX5,pmod(P,S,557))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.131+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) => p(HGNC:DDX5,pmod(P,S,557))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7525583

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7525583

Selventa

RAX-s8R0FM6JAhB0vzgmCoYnsPWrUnLplczDGfOxEZ3PM
has assertion: p(HGNC:IGF2) -| p(HGNC:ONECUT3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.138+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IGF2) -| p(HGNC:ONECUT3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7529237

4
value: In H4A7C2 cells, IGF II reduced CK19 and OC.3 protein levels and GGT, transferrin, and HNF-3 beta mRNA
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7529237

Selventa

RAfdMh1FBNnUF5SQd uJJA-Jxy8-velGVnArxlmkAnpto
has assertion: a(SCHEM:Calcium) -> r(HGNC:KRT1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.148+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> r(HGNC:KRT1)
label: p(HGNC:FGF7) -| (a(SCHEM:Calcium) -> r(HGNC:KRT1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7535082

5
value: TGF alpha, keratinocyte growth factor (KGF), and acidic fibroblast growth factor (aFGF), but not basic fibroblast growth factor (bFGF) or insulin-like growth factor type I, block Ca(2+)-mediated expression of K1 while inducing K8
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7535082

Selventa

RAbHKJgrKLVpmOle6AaCL1advw5N7ipm3NeqQ1uJoQlnI
has assertion: p(HGNC:MAPK1,pmod(P,Y)) => kin(p(HGNC:MAPK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.155+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MAPK1,pmod(P,Y)) => kin(p(HGNC:MAPK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7535768

5
value: Recombinant HVH2 phosphatase exhibited a high substrate specificity toward activated ERK and dephosphorylated both threonine and tyrosine residues of activated ERK1 and ERK2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7535768

Selventa

RASdE Ol5SXQXXgmUT3sMbN7ghbMMy5P5ZevmXFmrQHgA
has assertion: p(HGNC:MAPK3,pmod(P,T)) => kin(p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.156+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MAPK3,pmod(P,T)) => kin(p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7535768

5
value: Recombinant HVH2 phosphatase exhibited a high substrate specificity toward activated ERK and dephosphorylated both threonine and tyrosine residues of activated ERK1 and ERK2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7535768

Selventa

RAed8x pCvra2do1 YLO yFzESBGbopDpjMUyKXXGRn6Q
has assertion: phos(p(HGNC:DUSP4)) =| p(HGNC:MAPK3,pmod(P,T,202))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.159+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(HGNC:DUSP4)) =| p(HGNC:MAPK3,pmod(P,T,202))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7535768

5
value: Recombinant HVH2 phosphatase exhibited a high substrate specificity toward activated ERK and dephosphorylated both threonine and tyrosine residues of activated ERK1 and ERK2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7535768

Selventa

RAaSPf0D3TkuH0dwLSGxNghyi9o7YQMlEmK6sjecc0Uns
has assertion: phos(p(HGNC:DUSP4)) =| p(HGNC:MAPK3,pmod(P,Y,204))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.160+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(HGNC:DUSP4)) =| p(HGNC:MAPK3,pmod(P,Y,204))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7535768

5
value: Recombinant HVH2 phosphatase exhibited a high substrate specificity toward activated ERK and dephosphorylated both threonine and tyrosine residues of activated ERK1 and ERK2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7535768

Selventa

RAbhsufz5vBtAqqZqEvgDQMCsxHHU9JBv4kStuec7l9Gk
has assertion: p(HGNC:CD40) -> tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.166+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CD40) -> tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7537532

4
value: Cross-linked CD40L was found to induce nuclear expression of NF-kappa B, AP-1 and NF-AT with a time course and intensity similar to that produced by anti-Ig. Examination of NF-kappa B in more detail demonstrated that the CD40 mediated expression of DNA binding complexes correlated with induction of trans-activating activity which again attained similar levels following cross-linking of CD40 and slg. Despite the marked similarity in transcription factor induction triggered through CD40 and slg, differences in the intracellular signaling pathways utilized were apparent in that protein kinase C (PKC) depletion did not affect CD40 mediated induction of NF-kappa B even as induction by anti-Ig was abolished.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7537532

Selventa

RAcXF13GgRmKYzyochMWEx6MVFKpLqWiwERaF3GApuVMg
has assertion: a(SCHEM:Tretinoin) -> p(HGNC:IGFBP7)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.167+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Tretinoin) -> p(HGNC:IGFBP7)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7538673

3
value: We found that mac25 accumulates in senescent cells and is up-regulated in normal, growing mammary epithelial cells by all-trans-retinoic acid or the synthetic retinoid fenretinide.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7538673

Selventa

RATnSjWdHm2JLm6EcaxbcufGmmQcXAeTUIdoE6c2g1Ffg
has assertion: kin(p(HGNC:PRKCA)) => p(HGNC:KIT,pmod(P,S,821))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.171+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PRKCA)) => p(HGNC:KIT,pmod(P,S,821))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7539802

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7539802

Selventa

RAVMfj8zwaBZyGYFEFd5EzfW0AOVtCWIZsDA9yAlgGvWY
has assertion: a(SCHEM:Infliximab) =| p(HGNC:TNF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.175+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Infliximab) =| p(HGNC:TNF)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7540941

3
value: Observations in patients receiving infliximab (remicade) for treatment of rheumatoid arthritis or Crohn disease (Keane et al., 2001) have shown that antibody-mediated neutralization of TNF increases susceptibility to tuberculosis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7540941

Selventa

RAdhZbVZfbDMh6Dd8sGQqAYnxC4a1zA4YehsVtwSZx6dQ
has assertion: p(HGNC:FN1) -> p(HGNC:PTK2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.178+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:FN1) -> p(HGNC:PTK2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7541040

4
value: Tyrosine phosphorylation of Fak was induced by cell adhesion to Fibronectin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7541040

Selventa

RAW-LyNW7UdwqnQOw3raayuEzswWnW778xbJ6OBltRaXE
has assertion: a(SCHEM:Hydrocortisone) -| r(HGNC:NOS2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.187+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Hydrocortisone) -| r(HGNC:NOS2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7544010

3
value: We report that exposure of lipopolysaccharide-stimulated murine macrophages to therapeutic concentrations of aspirin (IC50 = 3 mM) and hydrocortisone (IC50 = 5 microM) inhibited the expression of iNOS and production of nitrite.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7544010

Selventa

RAT5jqyzCa7qCCuPjguUmhOSXdJhsAwqhLiLHDU9okaY4
has assertion: bp(GO:"response to stress") -> r(HGNC:PDIA5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.194+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to stress") -> r(HGNC:PDIA5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7556671

3
value: Northern blots showed that PDIR is preferentially expressed in cells actively secreting proteins and that the expression of PDIR is stress-inducible. These results suggested that PDIR has oxidoreductase activity of disulfide bonds against polypeptides and that it acts as a catalyst of protein folding in the lumen of the ER.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7556671

Selventa

RAbWMvtrYS 6KWuBbWZkgaIK6Vti4cTFz6euEYAofY1Hc
has assertion: bp(GO:"response to endoplasmic reticulum stress") -> r(HGNC:PDIA5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.195+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to endoplasmic reticulum stress") -> r(HGNC:PDIA5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7556671

3
value: Northern blots showed that PDIR is preferentially expressed in cells actively secreting proteins and that the expression of PDIR is stress-inducible. These results suggested that PDIR has oxidoreductase activity of disulfide bonds against polypeptides and that it acts as a catalyst of protein folding in the lumen of the ER.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7556671

Selventa

RAbBUWdCiqzTcRnB1V6RpcY2JfFka9ydENVBeJYiu70Js
has assertion: tscript(p(MGI:Nr3c1)) -> tscript(p(MGI:Cebpb))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.196+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Nr3c1)) -> tscript(p(MGI:Cebpb))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7557387

6
value: Induction of C/EBP beta DNA-binding activity in NIH-3T3 beta 2 cells exposed to dexamethasone in the presence of insulin and fetal bovine serum activates the expression of an adipocyte-specific nuclear hormone receptor, PPAR gamma, that stimulates the conversion of these fibroblasts into committed preadipocytes
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7557387

Selventa

RAbDAnuXN2vYlows4nG Uj7IY6RQsp6KvG6LgTG4sxKCg
has assertion: a(SCHEM:"cyclic AMP") -| p(RGD:Gucy1a2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.199+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -| p(RGD:Gucy1a2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7558233

3
value: These data indicate that cAMP-elevating agents decrease sGC activity, possibly by decreasing mRNA or protein levels or both.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7558233

Selventa

RAbdR44i26DbLGAAGWhQwhNlxRPDS7I16qiP-LP-EVOZc
has assertion: a(SCHEM:"cyclic AMP") -| p(RGD:Gucy1a3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.200+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -| p(RGD:Gucy1a3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7558233

3
value: These data indicate that cAMP-elevating agents decrease sGC activity, possibly by decreasing mRNA or protein levels or both.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7558233

Selventa

RAWn7SrHV8b1gTTwbF-witUutcuqivfdB4a7OdYFdazNU
has assertion: cat(p(HGNC:F2R)) -> p(HGNC:PLEK,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.207+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:F2R)) -> p(HGNC:PLEK,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7559410

5
value: Pleckstrin phosphorylation in response to thrombin receptor stimulation is progressively susceptible to inhibition by wortmannin, a potent and specific inhibitor of platelet PI 3-kinases
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7559410

Selventa

RAXwS-EaFz0TnfXFbMFQKAf7-ES-f5-xl7g6VzR4JzmH0
has assertion: kin(p(PFH:"PRKC Family")) -> p(HGNC:PLEK,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.218+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> p(HGNC:PLEK,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7559487

5
value: In human platelets activated with thrombin or phorbol esters, and in COS-1 cells expressing pleckstrin, a combination of phosphopeptide analysis and site-directed mutagenesis shows that three residues in the intervening sequence between the two pleckstrin PH domains become phosphorylated: Ser113, Thr114, and Ser117
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7559487

Selventa

RAQnLgQjFhKQVTPowy4JR6tys7lWf-lGtd tOSFS1yQxY
has assertion: kin(p(PFH:"PRKC Family")) -> p(HGNC:PLEK,pmod(P,T))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.219+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> p(HGNC:PLEK,pmod(P,T))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7559487

5
value: In human platelets activated with thrombin or phorbol esters, and in COS-1 cells expressing pleckstrin, a combination of phosphopeptide analysis and site-directed mutagenesis shows that three residues in the intervening sequence between the two pleckstrin PH domains become phosphorylated: Ser113, Thr114, and Ser117
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7559487

Selventa

RAYuqHBAc54AH1lRU42VJv24vmlFcBLic-FdnZYfmhsGo
has assertion: tscript(complex(NCH:"AP-1 Complex")) -> tscript(p(HGNC:ETV5))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.222+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"AP-1 Complex")) -> tscript(p(HGNC:ETV5))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7559555

5
value: The synergy between c-Jun and ERM may be attributed to the enhancing effect of c-Jun on the transcription activity of ERM, because c-Jun increased ERM transcription activity by more than 20-fold
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7559555

Selventa

RAb9tA21JrBHqqqDy8cmuTxrgMakuNwcwOkJ9Qw-DQ89I
has assertion: tscript(p(HGNC:JUN)) -> tscript(p(HGNC:ETV5))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.224+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:JUN)) -> tscript(p(HGNC:ETV5))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7559555

6
value: The synergy between c-Jun and ERM may be attributed to the enhancing effect of c-Jun on the transcription activity of ERM, because c-Jun increased ERM transcription activity by more than 20-fold
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7559555

Selventa

RAe01oa-B7cW MqSrh0DEZ0uWfdDFwywtDJJg98l6DBNU
has assertion: bp(GO:"macrophage activation") -> r(HGNC:LGALS3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.230+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"macrophage activation") -> r(HGNC:LGALS3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7573347

3
value: We now report that galectin-3 is expressed in normal human peripheral blood monocytes and its level increases dramatically as human monocytes differentiate into macrophages upon culturing in vitro.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7573347

Selventa

RAecYGRIcyCuvtR-rVCFy7db9oUJlGrqmlXKU79JwwcNg
has assertion: kin(p(MGI:Pdgfrb)) -> cat(p(MGI:Ptgs1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.239+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Pdgfrb)) -> cat(p(MGI:Ptgs1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7574691

6
value: The defect in PDGF-induced PGE2 release occurs prior to action of prostaglandin H synthase/cyclooxygenase as release of arachadonic acid (in response to PDGF) does not occur in the superoxide dismutase-overexpressing clones.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7574691

Selventa

RAXhzKs3DbFppZqUqDbYxiYV4ZR0pEfpM1S1mM-n3nA9o
has assertion: tscript(p(HGNC:CDX1)) => r(HGNC:HOXA7)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.256+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:CDX1)) => r(HGNC:HOXA7)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7585967

5
value: The presence of putative Cdx1-binding sites in Hox gene control regions as well as in vitro transactivation of Hoxa-7 indicates a direct regulation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7585967

Selventa

RAe-oNcTz3f9V-8G9dWxKe0xetPOWplhWbBzd45fy4vtQ
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -| r(MGI:Gjb5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.258+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -| r(MGI:Gjb5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7586191

3
value: Skin hyperplasia induced by one topical application of TPA was accompanied by hyperexpression of both Cx26 and Cx43. In addition, TPA significantly inhibited the expression of Cx31.1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7586191

Selventa

RAcjNJIR0wo 3gMG5IP77HvpYpPtu3A-VlWjho9zMwYUY
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Gja1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.259+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Gja1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7586191

3
value: Skin hyperplasia induced by one topical application of TPA was accompanied by hyperexpression of both Cx26 and Cx43. In addition, TPA significantly inhibited the expression of Cx31.1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7586191

Selventa

RAetAlP3oJc8B0KtGOEYi0Pk0-fkLktOc05CvsnUi6LQc
has assertion: r(HGNC:IL1R1) -> p(HGNC:CRH)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.263+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

r(HGNC:IL1R1) -> p(HGNC:CRH)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7588301

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7588301

Selventa

RAfTT8MjsmPjMhikkxoK tF13SO9kDHV3ZLlfaWhDIl9E
has assertion: gtp(p(HGNC:HRAS)) -> p(HGNC:ERF,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.264+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:HRAS)) -> p(HGNC:ERF,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7588608

5
value: The ERF protein is also hyperphosphorylated in cells transformed by the activated Ha-ras and v-src genes and the transcription repressor activity of ERF is decreased after co-transfection with activated Ha-ras or the kinase domain of the c-Raf-1 gene, indicating that ERF activity is probably regulated by the ras/MAPK pathway.......These data suggest that the repression ability of ERF may be regulated, at least partially, by phosphorylation of Thr526 (Substitution of Thr526 for glutamic acid also decreases the repression ability of ERF).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7588608

Selventa

RAQBXjFzlYyLEGQYxBn2a8sH4gWc11LJTYORPcyOqIm68
has assertion: complex(NCM:"activin A complex") -| r(MGI:Kit)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.275+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(NCM:"activin A complex") -| r(MGI:Kit)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7589515

3
value: We examined the effects of erythroid differentiation factor (EDF)/activin A on the expression of c-kit mRNA and protein in murine erythroleukemia (MEL) cells. EDF/activin A induced MEL cells to benzidine positive cells. Northern blot analysis showed that the c-kit mRNA expression was reduced synchronously with increase of beta-globin and uroporphyrinogen decarboxylase gene expression during EDF/activin A induced erythroid differentiation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7589515

Selventa

RAYXWmaT3mQ0CRLmnwDz7FDvBdMky15sg6P4pUHarwZGY
has assertion: path(MESHD:Hyperoxia) -> r(RGD:Cebpd)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.289+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Hyperoxia) -> r(RGD:Cebpd)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7598940

3
value: in addition to the antioxidant enzyme manganese superoxide dismutase, expression of a variety of stress-responsive genes including heme oxygenase-1, c-fos, c-jun, CAAT-enhancer binding protein (C/EBP)-beta, and C/EBP-delta were increased after hyperoxia.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7598940

Selventa

RAeZl7s73ZH0hgJQlAU 34dNMzrUZavFRw5l17G165Spo
has assertion: path(MESHD:Hyperoxia) -> r(RGD:Jun)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.292+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Hyperoxia) -> r(RGD:Jun)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7598940

3
value: in addition to the antioxidant enzyme manganese superoxide dismutase, expression of a variety of stress-responsive genes including heme oxygenase-1, c-fos, c-jun, CAAT-enhancer binding protein (C/EBP)-beta, and C/EBP-delta were increased after hyperoxia.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7598940

Selventa

RAUT1VRz5rW9yY24wo9bWbPhoSx5 t8UN6hjuazB0CZCo
has assertion: cat(p(RGD:Agtr1b)) -> r(RGD:Egf)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.302+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr1b)) -> r(RGD:Egf)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7611452

5
value: Through AT1 receptors, endogenous ANG II stimulates EGF and inhibits clusterin expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7611452

Selventa

RAQ7yMMz0AdTjPp6FgX0skJxOcc-S3sD9aBAyDxtzrINw
has assertion: p(HGNC:TNF) -> p(HGNC:CFB)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.317+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> p(HGNC:CFB)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7621584

4
value: Addition of IL-13 to fibroblast cultures treated with TNF-alpha resulted in a dose-dependent increase in C3 protein biosynthesis and a concomitant down-regulation of factor B protein biosynthesis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7621584

Selventa

RAXWAUbYUjs9rMNZLu1qqfuXsmPoGLDIZjGry3 EQzUQE
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -| r(HGNC:FDX1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.328+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -| r(HGNC:FDX1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7626497

3
value: In steroidogenic cell line Y1, the expression of ferredoxin was stimulated by cAMP and repressed slightly by angiotensin II and phorbol ester PMA
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7626497

Selventa

RAfYtzd7jaSrf1pmjat8Ukhf xJL7VsneJa3PbdO60xGg
has assertion: p(HGNC:PTPRB) -> bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.330+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PTPRB) -> bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7628014

3
value: The CAH domain of RPTP beta induced cell adhesion and neurite growth of primary tectal neurons, and differentiation of neuroblastoma cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7628014

Selventa

RAdl-YE0C4sWtwFVQOcmXljkZn1dUA-0hg8b1nfKhU3Kw
has assertion: p(HGNC:ADRB1,pmod(P)) =| cat(p(HGNC:ADRB1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.335+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ADRB1,pmod(P)) =| cat(p(HGNC:ADRB1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7629102

5
value: Overexpression of rhodopsin kinase, beta ARK1, beta ARK2, or GRK5 significantly increases agonist-induced beta 1AR phosphorylation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7629102

Selventa

RAduciiVJW66vRkw0NxJp8GrplZZ3o X0Bh xLOE SEpc
has assertion: p(PFH:"ADRB Family",pmod(P)) =| cat(p(PFH:"ADRB Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.336+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFH:"ADRB Family",pmod(P)) =| cat(p(PFH:"ADRB Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7629102

5
value: Overexpression of rhodopsin kinase, beta ARK1, beta ARK2, or GRK5 significantly increases agonist-induced beta 1AR phosphorylation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7629102

Selventa

RAV 2CILipqlDtuDClb2l-Iu070si0K2GOHFfPhYhgjUk
has assertion: kin(p(HGNC:CDK7)) -> kin(p(HGNC:CDK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.354+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:CDK7)) -> kin(p(HGNC:CDK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7629134

6
value: Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes. Members of two families of CDK inhibitors, p16/p18 and p21/p27, become physically associated with and inhibit the activity of CDKs in response to a variety of growth-modulating signals. Here, we show that the representative members of both families of CDK inhibitors, p21waf1,cip1, p27kip1, and p18, can prevent the phosphorylation of their CDK partners, CDK2 and CDK6, by CDK-activating kinase.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7629134

Selventa

RAVs8mubvDrUvroIyDAE-iYGcM4OrgYs4Q0clrdzcgOG8
has assertion: kin(p(HGNC:CDK7)) -> kin(p(HGNC:CDK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.356+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:CDK7)) -> kin(p(HGNC:CDK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7629134

6
value: Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes. Members of two families of CDK inhibitors, p16/p18 and p21/p27, become physically associated with and inhibit the activity of CDKs in response to a variety of growth-modulating signals. Here, we show that the representative members of both families of CDK inhibitors, p21waf1,cip1, p27kip1, and p18, can prevent the phosphorylation of their CDK partners, CDK2 and CDK6, by CDK-activating kinase.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7629134

Selventa

RAai6NnV3u6uNkxiibOF6ddOOIT XC2hkpgzywlZVbf8c
has assertion: p(HGNC:TNF) -| p(HGNC:RB1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.357+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -| p(HGNC:RB1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7629160

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7629160

Selventa

RAeWOyQt6xhUbyFphRBMiYYsLUTLKqI46gT9LgiUduISk
has assertion: a(CHEBI:testosterone) -> r(MGI:Tgfb1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.359+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:testosterone) -> r(MGI:Tgfb1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7632611

3
value: S115 + A cells possessed mRNA for both acidic FGF (aFGF) and TGF beta 1, both of which were increased by testosterone
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7632611

Selventa

RAUqWwYzt7WWOt4BCGfzBAcgMkq2v1Eq7EWw 3fOQSPVU
has assertion: kin(p(HGNC:MAPK1)) => p(HGNC:TOP2A,pmod(P,S,1361))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.361+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) => p(HGNC:TOP2A,pmod(P,S,1361))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7635160

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7635160

Selventa

RAWMYy3lDkyUmvVFie9xeyZDeCic5cu w8CEZLhXpafQ
has assertion: p(MGI:Ndn) -| bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.373+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ndn) -| bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7639751

3
value: These results suggest that necdin is a nuclear factor that governs the permanent arrest of cell growth of postmitotic neurons during development of the nervous systems of vertebrates.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7639751

Selventa

RAe23kPdZ2f3iTpRm4hxAiMhvDuFxWNkm0PMyY6NJB5wA
has assertion: p(HGNC:KRAS,sub(G,12,V)) => gtp(p(HGNC:KRAS))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.396+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: G,12,V
variant of: http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6407
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(HGNC:KRAS,sub(G,12,V)) => gtp(p(HGNC:KRAS))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7678540

5
value: From mutations file
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7678540

Selventa

RATo4P4s2u9koti58sQbYKQIXPF-N2U6HyrKifZuiUJ0I
has assertion: complex(p(MGI:Egf),p(MGI:Egfr)) -> tloc(p(MGI:Shc1),GOCCACC:"GO:0005737",GOCCACC:"GO:0005886")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.400+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(MGI:Egf),p(MGI:Egfr)) -> tloc(p(MGI:Shc1),GOCCACC:"GO:0005737",GOCCACC:"GO:0005886")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7681824

7
value: In the absence of EGF stimulation, SHC exists in the liver as a cytoplasmic monomer. Intraperitoneal injection of EGF results, within minutes, in the translocation of 50-80% of SHC to the liver plasma membrane. The membrane-associated SHC was found to be tyrosine-phosphorylated; the subsequent release of SHC from the membrane correlated with a tyrosine dephosphorylation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7681824

Selventa

RAeNU3AvWjcs5W43g3fdN7-GHtDyO3WYqlRKVaAJ0S81k
has assertion: p(RGD:Edn1) -> p(RGD:Anxa1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.404+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Edn1) -> p(RGD:Anxa1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7685351

4
value: Upon 32P labeling of these cells in culture, annexin I was immunoprecipitated using a specific polyclonal antibody and was found to incorporate radioactivity in a constitutive manner. However, as with epidermal growth factor (200 ng/ml), addition of angiotensin II (10(-7) M), arginine-vasopressin (10(-7) M), or endothelin I (10(-7) M) resulted in a 2-3-fold stimulation of annexin I phosphorylation. The basal phosphorylation as well as the stimulating effect of angiotensin II were also detected by immunoblotting annexin extracts using an antiphosphotyrosine antibody.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7685351

Selventa

RAbRt95dCwlzx8zhyWl5mUghei4ORmpC058XVCSHiMtFs
has assertion: p(HGNC:HNF1A) -> r(HGNC:LYZ)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.412+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:HNF1A) -> r(HGNC:LYZ)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7687846

4
value: The presence of HNF-1 recognition elements in functionally significant regulatory sites of the lysozyme gene and high levels of HNF-1 alpha in the oviduct is a strong indication for the involvement of HNF-1 alpha in the control of the lysozyme gene and possibly other egg white protein genes in the chicken oviduct.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7687846

Selventa

RAfG T0AB21WNRo9i5JuHS1SdCwqizBYqTx3hqFCswqS8
has assertion: p(RGD:Igf1) -> p(RGD:Igfbp3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.415+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Igf1) -> p(RGD:Igfbp3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7691580

4
value: IGF-I, IGF-II, and high concentrations of insulin increased IGFBP-2 and IGFBP-3 levels.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7691580

Selventa

RAfP1rxQHNM9n83B2pmhkDIouZ 9OI82Z8zeOHGO0UQCY
has assertion: a(CHEBI:histamine) -> r(HGNC:PENK)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.417+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:histamine) -> r(HGNC:PENK)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7693872

3
value: Combinations of IBMX plus nicotine, VIP, or histamine also synergistically enhanced proenkephalin synthesis, with no further elevation when the cells were also pretreated with pertussis toxin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7693872

Selventa

RAbb1B9P4h7GhZ5eS30gQ0zKq7JWoFuMzlBQ06U432UYo
has assertion: a(CHEBI:nicotine) -> r(HGNC:PENK)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.418+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:nicotine) -> r(HGNC:PENK)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7693872

3
value: Combinations of IBMX plus nicotine, VIP, or histamine also synergistically enhanced proenkephalin synthesis, with no further elevation when the cells were also pretreated with pertussis toxin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7693872

Selventa

RAVcCOyNyge3vR4jyZFsIbucHZ F48OsLuwsaQUqvsw-o
has assertion: complex(p(HGNC:RXRA),p(HGNC:NR4A2)) -> tscript(p(HGNC:RXRA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.422+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:RXRA),p(HGNC:NR4A2)) -> tscript(p(HGNC:RXRA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7705655

7
value: NGFI-B and NURR1, which have been shown previously to interact with DNA as monomers, also can heterodimerize with RXR.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7705655

Selventa

RAcmUz7lKNmHHwgi7yrrwIvtl4BcONQytCsenB-wCaLG4
has assertion: bp(GO:"response to heat") -> p(HGNC:HSP90AA1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.425+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to heat") -> p(HGNC:HSP90AA1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7706269

3
value: Upon heat shock, the level of Hsp90 is increased even more
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7706269

Selventa

RAVLR5enDT5GF6Vgdh-Cf-jY5oGGQNMn05hLu7TOCceXc
has assertion: a(SCHEM:Norepinephrine) -> cat(p(RGD:Lipe))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.442+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Norepinephrine) -> cat(p(RGD:Lipe))
label: cat(p(RGD:Pde3a)) -| (a(SCHEM:Norepinephrine) -> cat(p(RGD:Lipe)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7718614

7
value: OPC3911 completely blocked (IC50 = 0.3 microM) the maximal inhibitory effect of insulin on noradrenaline-induced lipolysis and the net dephosphorylation of hormone-sensitive lipase and other intracellular target proteins for insulin action, whereas insulin-induced lipogenesis was not changed.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7718614

Selventa

RAa9G7PACt1fgp1nVIU3kKC uTwoKkOblflvOrl7RJBg8
has assertion: cat(p(RGD:Pde3a)) -| cat(p(RGD:Lipe))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.443+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Pde3a)) -| cat(p(RGD:Lipe))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7718614

6
value: OPC3911 completely blocked (IC50 = 0.3 microM) the maximal inhibitory effect of insulin on noradrenaline-induced lipolysis and the net dephosphorylation of hormone-sensitive lipase and other intracellular target proteins for insulin action, whereas insulin-induced lipogenesis was not changed.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7718614

Selventa

RAcJdiiZI5myTlZZu8B WZKoP4-I-RcUzxOAL4FiAX iM
has assertion: kin(p(PFM:"Prkc Family")) -> r(MGI:Plk3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.453+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFM:"Prkc Family")) -> r(MGI:Plk3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7730342

5
value: FGF-1 induction of Fnk mRNA expression is first detected at 30 min after mitogen addition, reflects transcriptional activation, and does not require de novo protein synthesis. FGF-2, platelet-derived growth factor-BB, calf serum, or phorbol myristate acetate treatment of quiescent cells also induces fnk gene expression
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7730342

Selventa

RAYbJF3Hcuutwl9ofrqosu pSO5T xdvsf5S62dyX7 a0
has assertion: kin(p(HGNC:MET)) -> p(HGNC:SHC1,pmod(P,Y,317))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.459+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MET)) -> p(HGNC:SHC1,pmod(P,Y,317))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7731718

5
value: After stimulation of the HGF receptor, Shc is phosphorylated on Y317VNV, generating an high affinity binding site for Grb2 (Kd = 15 nM). This duplicates the high affinity binding site for Grb2 present on the HGF receptor (Y1356VNV).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7731718

Selventa

RAebDoXW4 xnu iIGb-IqA7zBPoIXgbcXKKwYn9E-0FT0
has assertion: complex(p(HGNC:SHC1),p(HGNC:GRB2)) -> gtp(p(PFH:"RAS Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.509+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:SHC1),p(HGNC:GRB2)) -> gtp(p(PFH:"RAS Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7731718

7
value: Thus HGF stimulation can trigger the Ras pathway by recruiting Grb2 both directly through the receptor, and indirectly, through Shc.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7731718

Selventa

RAeEOCylEeqCxq8aV-nY2ASW2sy06e-UXjgm2o8HxvExg
has assertion: p(HGNC:ATF2,pmod(P,T,69)) => tscript(p(HGNC:ATF2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.520+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ATF2,pmod(P,T,69)) => tscript(p(HGNC:ATF2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7737130

5
value: Mutation of either Thr69 or Thr71, or both, led to an almost complete loss of inducibility.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7737130

Selventa

RAYkEI0NK9ZD5oF2m9XHo7HwuPp87I05xyF-IEQRpeWkU
has assertion: kin(p(HGNC:MAPK8)) => p(HGNC:JUN,pmod(P,S,73))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.529+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK8)) => p(HGNC:JUN,pmod(P,S,73))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7737130

5
value: p54/46 ATF-2 kinases were bound to the GST-ATF-2 column and after elution of the kinases from the column with 2 M urea, fractions were tested for kinase activity (Figure 7A)....we used a mutant of ATF-2 containing point mutations at positions Thr69, Thr71 and Ser9O. As shown in Figure 7B (right panel), both the kinases purified with GST-ATF-2 and with GST-Jun (JNK) hardly phosphorylated GST-ATF-2 protein lacking the putative phosphoacceptor sites (M).....The GST-c-Jun protein containing point mutations at positions Ser63 and Ser73 (M) was phosphorylated less efficiently than wild-type c-Jun (W) by ATF-2 kinases (Figure 7B, left panel), similar to that found for p54/46 JNK (Hibi et al., 1993).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7737130

Selventa

RAUWkWrFri1y GKVbwdFv825iuEmuXZDASchZPl5OBBzk
has assertion: kin(p(HGNC:MAPK9)) => p(HGNC:JUN,pmod(P,S,63))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.532+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK9)) => p(HGNC:JUN,pmod(P,S,63))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7737130

5
value: p54/46 ATF-2 kinases were bound to the GST-ATF-2 column and after elution of the kinases from the column with 2 M urea, fractions were tested for kinase activity (Figure 7A)....we used a mutant of ATF-2 containing point mutations at positions Thr69, Thr71 and Ser9O. As shown in Figure 7B (right panel), both the kinases purified with GST-ATF-2 and with GST-Jun (JNK) hardly phosphorylated GST-ATF-2 protein lacking the putative phosphoacceptor sites (M).....The GST-c-Jun protein containing point mutations at positions Ser63 and Ser73 (M) was phosphorylated less efficiently than wild-type c-Jun (W) by ATF-2 kinases (Figure 7B, left panel), similar to that found for p54/46 JNK (Hibi et al., 1993).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7737130

Selventa

RARgxzKuPCS2iZAPeFow-KpCfsPsWL63h823I8nnm8184
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> tscript(p(HGNC:JUN))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.533+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> tscript(p(HGNC:JUN))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7737130

4
value: transactivation by the Gal4-c-Jun hybrid protein containing the transactivation domain of c-Jun was enhanced by both TPA and UV. In HeLa and GM637 cells, Gal4-c-Jun was already an efficient transactivator in unstimulated cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7737130

Selventa

RAWue9Gd8JH2GO5LzR 38mHsEkFBz-CQ0J6v03obQOA84
has assertion: p(HGNC:RB1) -| complex(p(HGNC:E2F2),p(HGNC:TFDP1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.536+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:RB1) -| complex(p(HGNC:E2F2),p(HGNC:TFDP1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7739537

6
value: DP-1 and DP-2 associate with Rb protein when complexed with E2F-1, E2F-2 and E2F-3. Rb is able to block transcriptional activation of all of these E2F/DP dimers.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7739537

Selventa

RAXXKEIiFN7dZ2NPScRbM6AGIwIvdSJEJ4-Zwyj5lrNeM
has assertion: tscript(p(HGNC:RB1)) -| tscript(complex(p(HGNC:E2F1),p(HGNC:TFDP2)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.539+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:RB1)) -| tscript(complex(p(HGNC:E2F1),p(HGNC:TFDP2)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7739537

8
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7739537

Selventa

RAbjiivVjhxmePoFiLAzPzNDor7LpHjCozqLtLNhFuSq4
has assertion: kin(p(HGNC:PRKCZ)) => p(HGNC:PRKCZ,pmod(P,T,560))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.554+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PRKCZ)) => p(HGNC:PRKCZ,pmod(P,T,560))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7744003

5
value: [14C]ceramide specifically binds to and regulates kinase activity of PKC zeta in a biphasic manner. Binding studies indicate high and low affinity binding with bmax values of 60 and 600 nM and Kd values of 7.5 and 320 nM respectively. At ceramide concentrations as low as 0.5 nM an up to 4-fold increase in autophosphorylation is obtained
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7744003

Selventa

RAdAy-eI6rY1noWVCkkBBmg81Fh2ix frMnVbtsk8RrRQ
has assertion: a(CHEBI:calcitriol) -> r(HGNC:PTPRO)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.558+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:calcitriol) -> r(HGNC:PTPRO)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7753550

3
value: Interestingly, its gene expression was enhanced by various differentiation-inducing agents, such as phorbol ester, dihydroxy vitamin D3, retinoic acid, and dimethyl sulfoxide.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7753550

Selventa

RAS8F92r3qBpWC97qg863aya-R6LYRkZSHjFLZKyrNupA
has assertion: a(CHEBI:thapsigargin) -| r(HGNC:FN1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.561+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:thapsigargin) -| r(HGNC:FN1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7756462

3
value: Thapsigargin, an agent that mobilizes Ca2+ from internal stores, suppressed basal and progesterone-induced fibronectin production in the absence and presence of cyanoketone.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7756462

Selventa

RAWL9dBJq42ne-nbufRP1F4PJ8Lw2AbkGvG6FfHvF 35M
has assertion: a(CHEBI:"arachidonic acid") -> p(MGI:Tnni3,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.569+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"arachidonic acid") -> p(MGI:Tnni3,pmod(P))
label: a(SCHEM:"Calphostin C") -| (a(CHEBI:"arachidonic acid") -> p(MGI:Tnni3,pmod(P)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7758155

4
value: Incubation with either PMA, AA, or ET resulted in similar increases in 32Pi incorporation into troponin I (TnI) and myosin light chain 2 (MLC2), which was inhibited by preincubation with the protein kinase C antagonist calphostin C
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7758155

Selventa

RATjDQaYpIqaOrYEmzBHHGr6N4WJ7kYCLyDsf AxD0GmY
has assertion: a(SCHEM:"Calphostin C") -| (a(SCHEM:"Tetradecanoylphorbol acetate") -> p(MGI:Myl9,pmod(P)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.572+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Calphostin C") -| (a(SCHEM:"Tetradecanoylphorbol acetate") -> p(MGI:Myl9,pmod(P)))
label: a(SCHEM:"Tetradecanoylphorbol acetate") -> p(MGI:Myl9,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7758155

4
value: Incubation with either PMA, AA, or ET resulted in similar increases in 32Pi incorporation into troponin I (TnI) and myosin light chain 2 (MLC2), which was inhibited by preincubation with the protein kinase C antagonist calphostin C
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7758155

Selventa

RAW6IvV2B-uyKD65EkxZjMPtyAvvb6oP-KlRcTMZUuhs0
has assertion: p(RGD:Ngf) -> r(RGD:Cat)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.590+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ngf) -> r(RGD:Cat)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7768207

4
value: NGF protects PC12 cells from H2O2 injury by stimulating the synthesis of antioxidant enzymes including catalase, GSH Px, glucose-6-phosphate dehydrogenase, and gamma-glutamylcysteine synthetase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7768207

Selventa

RATXHw8xi8wJymjRkXd0FFBm7dgiVD-tSFhGwRAJywa7k
has assertion: kin(p(HGNC:MAPK3)) => p(HGNC:LIFR,pmod(P,S,1044))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.601+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK3)) => p(HGNC:LIFR,pmod(P,S,1044))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7777512

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7777512

Selventa

RAa4HmH-q5AARe h1k6eT5qZ--tx03Vqm4mcc67Mu8sYM
has assertion: a(CHEBI:mifepristone) -> r(HGNC:FABP3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.614+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:mifepristone) -> r(HGNC:FABP3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7790381

3
value: Two other antiprogestins, Mifepristone and Onapristone, likewise stimulated MDGI expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7790381

Selventa

RAdHCqUBtWFx c3VCRqeH26HuorjYPSdP3vXAm2d5pL5g
has assertion: p(HGNC:C7) -> cat(p(HGNC:PLAT))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.626+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:C7) -> cat(p(HGNC:PLAT))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7814888

5
value: Radioligand binding studies revealed that the isolated component, as well as C7 after its incorporation into the terminal complement complex C5b-9, can bind plasminogen. Binding was inhibited by the lysine analogues 6-aminohexanoic acid and tranexamic acid, implicating the lysine binding sites of plasminogen into the binding interaction. tPA-mediated plasminogen activation was enhanced in the presence of C7.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7814888

Selventa

RAYq6YnibZ9J3-eo8iybJsDat CEFbjBWe0VeVz 3LueY
has assertion: p(EGID:3630) -> tscript(p(HGNC:CEBPB))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.632+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:3630) -> tscript(p(HGNC:CEBPB))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7822291

5
value: Gel shift analysis revealed that 6 h of insulin treatment decreased the binding of nuclear C/EBP alpha while increasing binding of nuclear C/EBP beta and C/EBP delta.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7822291

Selventa

RAU vXPIOgn9gwLyKoNJDi0qENAKzq81MlE1ZhgpW61Dc
has assertion: p(EGID:3630) -| r(HGNC:CEBPA)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.634+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:3630) -| r(HGNC:CEBPA)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7822291

4
value: Treatment of adipocytes with insulin stimulated rapid dephosphorylation of C/EBP alpha, and repressed the expression of C/EBP alpha within 2-4 h, with > 90% suppression occurring at 24 h.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7822291

Selventa

RASrSD4BcZbcNbsnyjcbsJ5x8G5xJzAk8jXYSn66qTCUw
has assertion: kin(p(HGNC:MAPK10)) => p(HGNC:MAPK10,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.640+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK10)) => p(HGNC:MAPK10,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7826642

5
value: JNK3 autophosphorylates both threonine and tyrosine residues
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7826642

Selventa

RAQDYVToxMLIb3apbIjD53xdkZY-k0Qr-5BPE2eUTRRk8
has assertion: a(CHEBI:"okadaic acid") -| r(HGNC:FOS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.642+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"okadaic acid") -| r(HGNC:FOS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7835407

3
value: H7 (50 microM), genistein (2 microM) and okadaic acid (20 nM), all block the induction of c-jun and c-fos mRNA accumulation in the H2O2-treated rat lenses.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7835407

Selventa

RAdYQRQkid6JlyYdX5N0REIGaBiIZ1PeHUND7CstfqnVs
has assertion: a(CHEBI:"okadaic acid") -| r(HGNC:JUN)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.643+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"okadaic acid") -| r(HGNC:JUN)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7835407

3
value: H7 (50 microM), genistein (2 microM) and okadaic acid (20 nM), all block the induction of c-jun and c-fos mRNA accumulation in the H2O2-treated rat lenses.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7835407

Selventa

RAaQ wRkHLiWQp5wQ8jwmV9iLDt nYSExczmMaSDinzJo
has assertion: a(SCHEM:Calcium) -> surf(p(HGNC:SRI))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.644+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> surf(p(HGNC:SRI))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7835417

4
value: is now shown to undergo a calcium-dependent translocation process from the cytosol to cellular membranes in both systems.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7835417

Selventa

RAWEM-c6n5hVsNVEbHeynM2WzRUcGfj2S4NpSAifNyF2I
has assertion: kin(p(HGNC:MAP2K3)) => p(HGNC:MAP2K3,pmod(P,S,218))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.647+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAP2K3)) => p(HGNC:MAP2K3,pmod(P,S,218))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7839144

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7839144

Selventa

RAUwHarjU1FsgrRFeg37HCwMFbuJe2E3nbev4GNZE bRo
has assertion: complex(p(MGI:Nck1),p(MGI:Sos1)) => gtp(p(PFM:"Ras Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.657+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(MGI:Nck1),p(MGI:Sos1)) => gtp(p(PFM:"Ras Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7862111

7
value: We also found that NCK binds directly to the guanine nucleotide exchange factor SOS. This interaction is mediated by the SH3 domains of NCK. These findings suggest that NCK can regulate p21ras-dependent gene transcription through interaction with SOS protein.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7862111

Selventa

RAWdVznaPMFvu5F5V7Tj5mWoJ9rcpWk1p0Dfk8fTMgRu8
has assertion: bp(GO:"response to hypoxia") -| r(RGD:Npr3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.659+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to hypoxia") -| r(RGD:Npr3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7864153

3
value: ANPCR-mRNA levels were selectively and significantly downregulated by 48-h and 4-wk hypoxia in lung but were unchanged or upregulated in other tissues.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7864153

Selventa

RAXg0Anf24vIweOXjcqzywqHKL1-GOw0jY0kZ-3mcgH3o
has assertion: a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.662+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7872806

2
value: Short-term Se(-) cells were more sensitive to H2O2-induced killing than Se(+) cells,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7872806

Selventa

RAXWqG kSI38md2gYm3npRs3-W7-QnrBi1wMnlTgZ-XH4
has assertion: a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.664+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death")
label: a(SCHEM:Selenium) -| (a(CHEBI:"hydrogen peroxide") -> bp(GO:"cell death"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7872806

3
value: Short-term Se(-) cells were more sensitive to H2O2-induced killing than Se(+) cells,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7872806

Selventa

RAYhkkk1UN9puWDqKxiU0VG8ZaTNyO3-deammCs0cqE-U
has assertion: kin(p(PFH:"MEK1/2 Family")) => p(HGNC:MAP2K1,pmod(P,S,25))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.665+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"MEK1/2 Family")) => p(HGNC:MAP2K1,pmod(P,S,25))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7873542

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7873542

Selventa

RAZyb69zol63oMpKR-TswiQFfg-P163FVHYRXomvTFrQ0
has assertion: tscript(p(HGNC:POU2F2)) -> r(HGNC:RPN1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.669+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:POU2F2)) -> r(HGNC:RPN1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7885824

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7885824

Selventa

RAZarQFtrKcfzsqXFz0iHNyftgvlhIFX1-mz8wIHhAIxQ
has assertion: bp(GO:"macrophage differentiation") -> r(MGI:Mpeg1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.670+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"macrophage differentiation") -> r(MGI:Mpeg1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7888681

3
value: The expression of Mpg-1 was found to increase when murine fetal liver hematopoietic progenitor cells were induced to differentiate into macrophages
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7888681

Selventa

RAU 9h79OSY3A8w8xYtbd92FyPrm49o9XiCol Fc75p-k
has assertion: a(CHEBI:dopamine) -> p(HGNC:NDUFAB1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.677+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:dopamine) -> p(HGNC:NDUFAB1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7895801

3
value: In 43.5% of slices tested, dopamine preferentially and irreversibly facilitated SDAP production at low bath concentrations (1-100 microM), but at concentrations > 100 microM suppressed all components of the epileptiform responses.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7895801

Selventa

RATWZ1p6mEMrRwID3vDhu0l6ArFYx4mIWoNuFf3FVj2fA
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:IMPDH2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.683+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:IMPDH2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7896827

3
value: Recent studies by our group have shown that activation of peripheral blood T lymphocytes with the mitogens PMA and ionomycin results in a 10- and 15-fold induction of IMPDH type II mRNA expression and total cellular enzymatic activity, respectively
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7896827

Selventa

RAZ6fbj7Sgan8hU VxYoPDSVsVUOabKwknkN7o1pPr7gA
has assertion: p(HGNC:NGF) -> r(HGNC:PRNP)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.689+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:PRNP)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7902706

4
value: Growth factors like NGF are known to increase the expression of PrP gene, a housekeeping gene which is responsible for susceptibility to transmissible spongiform encephalopathies.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7902706

Selventa

RASToV0LIZiBoxfmPvweZzSYF9aoC6oaPhnkaRBYO13Ak
has assertion: p(HGNC:EGF) -> p(HGNC:CALM1,pmod(P,Y,99))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.698+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> p(HGNC:CALM1,pmod(P,Y,99))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7925415

4
value: An epidermal-growth-factor(EGF)-receptor preparation isolated by calmodulin-affinity chromatography from rat liver plasma membranes is able to phosphorylate calmodulin. Calmodulin phosphorylation was enhanced 3-8-fold by EGF, was dependent on the presence of a polycation or basic protein and was inhibited by micromolar concentrations of Ca2+. Phosphate incorporation into calmodulin occurs predominantly on tyrosine residues. Partial proteolysis of phosphocalmodulin by thrombin identifies Tyr99, located in the third calcium-binding domain of calmodulin, as the phosphorylated residue.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7925415

Selventa

RAdQxKfa93aqdpGr0hHdiMgRFvBJAEhSdRaNw3Odxn4Io
has assertion: p(HGNC:TGFB1) -> path(MESHD:Fibrosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.705+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TGFB1) -> path(MESHD:Fibrosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7935686

3
value: TGF-beta has been implicated as a cause of fibrosis in most forms of experimental and human kidney disease
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7935686

Selventa

RAQuUlKiH3lxD8jeG5Lj 6y gN9V8L-MiDN-S aXa6xAU
has assertion: cat(p(HGNC:HNMT)) -| a(CHEBI:histamine)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.715+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:HNMT)) -| a(CHEBI:histamine)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7943261

4
value: In mammals, histamine is inactivated principally by two enzymes: histamine N-methyltransferase (HMT; EC 2.1.1.8) and diamine oxidase (DAO; EC 1.4.3.6.)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7943261

Selventa

RAW7mcEfOVW601y3lpAhkxmHXeK6kDiSN5XFSjjTCbHSk
has assertion: p(MGI:Mos) -> tscript(p(MGI:Elk3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.723+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Mos) -> tscript(p(MGI:Elk3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7958835

5
value: Strikingly, Ras, Src, and Mos expression switch Net activity to positive.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7958835

Selventa

RAabdUE4vXmVZaejU6se0OCjc2 sQdwvs0q0t2AqRY0-s
has assertion: p(MGI:Rasa1) -> tscript(p(MGI:Elk3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.725+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Rasa1) -> tscript(p(MGI:Elk3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7958835

5
value: Strikingly, Ras, Src, and Mos expression switch Net activity to positive.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7958835

Selventa

RAfudPzaR8zXbzA7cfvuQ2R0SqL6QZTFEN5xNNs0JqY88
has assertion: p(MGI:Src) -> tscript(p(MGI:Elk3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.726+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Src) -> tscript(p(MGI:Elk3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7958835

5
value: Strikingly, Ras, Src, and Mos expression switch Net activity to positive.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7958835

Selventa

RAe915K0J6QGXjH72UqPRmGu4BMJefPmp6MIEAF8ed0Uk
has assertion: p(HGNC:AMBP) -| cat(p(HGNC:ELANE))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.747+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:AMBP) -| cat(p(HGNC:ELANE))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7982890

5
value: The second domain (R-020) of human urinary trypsin inhibitor (UTI) exerts similar inhibitory activities on trypsin, alpha-chymotrypsin, leukocyte elastase, and plasmin to those of UTI itself, and additionally inhibits coagulation factor Xa (FXa) and plasma kallikrein
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7982890

Selventa

RASKgfDEqPniWaWPlTUoh5gz4SBl5CEYpP0H2XQQeR5G0
has assertion: p(HGNC:AMBP) -| cat(p(HGNC:PRSS1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.749+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:AMBP) -| cat(p(HGNC:PRSS1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7982890

5
value: The second domain (R-020) of human urinary trypsin inhibitor (UTI) exerts similar inhibitory activities on trypsin, alpha-chymotrypsin, leukocyte elastase, and plasmin to those of UTI itself, and additionally inhibits coagulation factor Xa (FXa) and plasma kallikrein
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7982890

Selventa

RAYydwPRWTuSBMrKZ1V3Iho7pLeqf9MQAba3z b0YQj7Y
has assertion: complex(p(HGNC:EPHA2),p(HGNC:PIK3R2)) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.751+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:EPHA2),p(HGNC:PIK3R2)) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7982920

6
value: Additionally, Eck coimmunoprecipitated with p85 in ligand activated cells confirming their interaction in vivo. In keeping with the above observations, activation of Eck by its ligand, B61, increased phosphatidylinositol 3-kinase activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7982920

Selventa

RAZQfv x-ffgRcqr3ZN HU5PQdEL69mWOEeLbs6E3ZiAs
has assertion: p(HGNC:IFNG) -> p(HGNC:CD74)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.755+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IFNG) -> p(HGNC:CD74)
label: p(HGNC:RB1) -> (p(HGNC:IFNG) -> p(HGNC:CD74))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/7997248

6
value: IFN-gamma induction of CD74 surface expression in a series of breast carcinoma lines is enhanced by RB, while RB has no effect on CD74 mRNA induction.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/7997248

Selventa

RAebcSisA8gZTq1iaF0sQ5mX0GCNCQLIrbUydQTvXUW0I
has assertion: kin(p(HGNC:MAPK9)) => tscript(p(HGNC:JUN))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.759+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK9)) => tscript(p(HGNC:JUN))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8001819

6
value: transcriptional activity of the c-Jun protooncoprotein is augmented through phosphorylation at 2 sites by c-Jun amino-terminal kinases, JNKs
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8001819

Selventa

RASc r0-u3tddIZU3jYKknxWBWqoga5R15iVOniOHr1bU
has assertion: bp(GO:"response to radiation") -> r(HGNC:CDKN1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.764+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to radiation") -> r(HGNC:CDKN1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8012956

3
value: DNA damage elicited by gamma-irradiation induces WAF1/CIP1 in normal human and mouse fibroblasts but does not affect WAF1/CIP1 expression in p53-deficient cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8012956

Selventa

RAaYrp-Qcgv57AJu--Cw 4g1z7GaaJ4UkN OjKiM ks8
has assertion: p(HGNC:IGF2) -| p(HGNC:IGF1R)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.765+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IGF2) -| p(HGNC:IGF1R)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8014604

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8014604

Selventa

RAVjU4BfArX1wgVq2iEkJqBPWGfYTJmjQajSDSyDcxSzM
has assertion: p(HGNC:IL1B) -> p(HGNC:CSF1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.767+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL1B) -> p(HGNC:CSF1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8019788

4
value: Constitutive secretion of Macrophage Colony Stimulating Factor (M-CSF) was observed in RA (Rheumatoid arthritis) synovial fibroblasts. Stimulation with IL-1beta led to a marked, time-dependent increase in the production of M-CSF mRNA and protein.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8019788

Selventa

RAdpM8pcsRFKBGMjlmnktvqFEhoektqa8BnrVOVzLG2P8
has assertion: a(CHEBI:glucocorticoid) -> r(HGNC:MT1H)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.777+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glucocorticoid) -> r(HGNC:MT1H)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8049263

3
value: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8049263

Selventa

RASZUJ46lJtI4rEuwX0cqpNIkmFmm-bP-80pS7AqNyrVQ
has assertion: a(SCHEM:Stanolone) -> r(HGNC:AZGP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.778+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Stanolone) -> r(HGNC:AZGP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8049458

3
value: Northern blot analysis revealed that dexamethasone and 5 alpha-dihydrotestosterone strongly induced the accumulation of Zn-alpha 2-gp mRNA in T-47D human breast cancer cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8049458

Selventa

RAT8xlniAmaTuRWgmlGMNCOJVhZQ5PojxlBWAua3WPKoc
has assertion: p(HGNC:IDE) -> tscript(p(HGNC:AR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.780+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IDE) -> tscript(p(HGNC:AR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8051160

5
value: We recently identified a protein, designated receptor accessory factor (RAF), that interacts directly with and enhances the DNA binding of androgen (AR) and glucocorticoid (GR) receptor peptide fragments
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8051160

Selventa

RAZUQ8RxrNjd6nw7RQI3oAX9Pw2Sm z2hrTHZhLbQIcaY
has assertion: p(HGNC:SOS1) -| tscript(p(HGNC:ETS1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.782+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:SOS1) -| tscript(p(HGNC:ETS1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8058333

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8058333

Selventa

RASmoE-cg40eTpsn4CHaqqXz9NrkABWSyEZyT26BJndhE
has assertion: kin(p(PFH:"PRKA Family")) => p(HGNC:CCND1,pmod(P,S,197))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.783+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKA Family")) => p(HGNC:CCND1,pmod(P,S,197))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8058338

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8058338

Selventa

RAeX1POZW0DN6eCCrqlufeJviUcTEk8BglkjA1hx9aU2o
has assertion: a(CHEBI:clofibrate) -| (a(SCHEM:Tretinoin) -| sec(p(MGI:Cga)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.788+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:clofibrate) -| (a(SCHEM:Tretinoin) -| sec(p(MGI:Cga)))
label: a(SCHEM:Tretinoin) -| sec(p(MGI:Cga))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8070357

5
value: All-trans-retinoic acid and 9-cis-retinoic acid increased CG secretion and CG alpha and CG beta mRNAs, but clofibric acid blunted these stimulatory effects. WY 14,643, another peroxisome proliferator, also reduced CG gene expression
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8070357

Selventa

RAS nE2BZEki8zwF6d3fik qYis1UgByYHzzrRlOt6KfM
has assertion: p(HGNC:NGF) -> r(HGNC:MYC)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.800+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:MYC)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8087425

4
value: The expression of c-Myc mRNA is rapidly induced by nerve growth factor (NGF) and epidermal growth factor (EGF) in PC-12 pheochromocytoma cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8087425

Selventa

RAZXVQ5mC-TY5j6TuwrONtDD1FSHiH1gfa8Nc2Yko-rc8
has assertion: p(HGNC:E2F1,pmod(P,S,337)) => tscript(p(HGNC:E2F1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.802+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:E2F1,pmod(P,S,337)) => tscript(p(HGNC:E2F1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8087847

5
value: We have studied the interaction of E2F-1 with the Rb and adenovirus E4 proteins and show that phosphorylation of E2F-1 on serine residues 332 and 337 prevented its interaction with Rb but was a prerequisite for interaction with E4. (PhosphoElm data from PMID 15212693)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8087847

Selventa

RAXKG62wxLQnuUJ HavxQ6hej yzxVqVFXFGaG7CcHPag
has assertion: p(HGNC:TNF) -| p(HGNC:ERBB2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.817+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -| p(HGNC:ERBB2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8105469

4
value: There was a 50% decrease in the protein level after incubation with TNF-alpha for 36 hours.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8105469

Selventa

RAau-bdAxVoWAoF9ZDG-ZLk-5QblTLX3T9gA3L4FOKfUM
has assertion: kin(p(HGNC:NTRK2)) => p(HGNC:PLCG1,pmod(P,Y,1254))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.818+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:NTRK2)) => p(HGNC:PLCG1,pmod(P,Y,1254))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8106527

5
value: Following activation of TrkB, phospholipase C-gamma 1 is phosphorylated on Tyr-783, Tyr-771, and Tyr-1254. Phospholipase C-gamma 1 also forms a complex with TrkB in response to neurotrophin-3 treatment, consistent with the possibility that one of the TrkB autophosphorylation sites provides a binding site for the phospholipase C-gamma 1 SH2 domains, as is the case for other receptor protein-tyrosine kinases. We conclude that phospholipase C-gamma 1 is directly phosphorylated by TrkB.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8106527

Selventa

RAS0Z8oJPeZ1nKj4VRNgofe5Qm2sYc1UNdCtO2UgFD eo
has assertion: kin(p(HGNC:NTRK2)) => p(HGNC:NTRK2,pmod(P,Y,674))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.824+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:NTRK2)) => p(HGNC:NTRK2,pmod(P,Y,674))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8106527

5
value: In response to brain-derived neurotrophic factor and neurotrophin-3 treatment, TrkB expressed exogenously in Rat-2 cells is rapidly phosphorylated on tyrosine residues. At least 2 regions of TrkB contain phosphorylated tyrosines. The major sites of autophosphorylation are in the region containing Tyr-670, Tyr-674, and Tyr-675, which lies in the kinase domain and corresponds by sequence homology to the Tyr-416 autophosphorylation site in p60c-Src. Tyr-785, which lies just to the COOH-terminal side of the kinase domain in a relatively short tail characteristic of the Trk family of protein-tyrosine kinase receptors, is also phosphorylated in response to neurotrophin-3 treatment.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8106527

Selventa

RAfe2x-TiDcyC9bpkjE6mvgR-ewaq7i1Oy7N8PeqoG6YA
has assertion: complex(p(MGI:Nfe2),p(MGI:Mafk)) => tscript(p(MGI:Nfe2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.828+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(MGI:Nfe2),p(MGI:Mafk)) => tscript(p(MGI:Nfe2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8107826

7
value: We show here that products of the maf proto-oncogene family, MafF, MafG and MafK (the small Maf proteins) which possess a b-zip DNA-binding domain but lack a canonical transactivation domain, directly control the DNA-binding properties of p45 by heterodimeric association with p45. Whereas homodimers of the small Maf proteins act as negative regulators, heterodimers composed of Maf and p45 support active transcription in vivo.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8107826

Selventa

RAb0ywFS5kEz15EGlWm5RfYK5dDGABl1Eaj1YtLXgNyF8
has assertion: gtp(p(PFH:"RAS Family")) -> r(HGNC:MSR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.831+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(PFH:"RAS Family")) -> r(HGNC:MSR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8114743

5
value: These observations suggest that SR gene expression is regulated via a signal transduction pathway involving ras, AP-1, and ets domain proteins
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8114743

Selventa

RAbD22p82Km1FtKxEhFDmvkPslMuLq5Mq9RWl7EEhIIbk
has assertion: tscript(complex(NCH:"AP-1 Complex")) -> r(HGNC:MSR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.833+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"AP-1 Complex")) -> r(HGNC:MSR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8114743

4
value: These observations suggest that SR gene expression is regulated via a signal transduction pathway involving ras, AP-1, and ets domain proteins
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8114743

Selventa

RAUi1r4FP0j5P36DGjlw88eafd-p0n-2Lz uXJtm0YUD8
has assertion: a(CHEBI:calcitriol) -> r(HGNC:CA2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.837+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:calcitriol) -> r(HGNC:CA2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8119191

3
value: 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3; 10 nM] and phorbol myristate acetate (10 ng/ml), doses that cause monocytic differentiation of the HL-60 cell, induced small increases in CA-II mRNA
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8119191

Selventa

RAZGxlAeoLrg9NOr1P638HCqJFnrRQYZsY7tT2Nyeq55I
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:CA2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.838+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:CA2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8119191

3
value: 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3; 10 nM] and phorbol myristate acetate (10 ng/ml), doses that cause monocytic differentiation of the HL-60 cell, induced small increases in CA-II mRNA
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8119191

Selventa

RAR3T0l7ElEyKsPAurPJt27iplgr8ykLHb4cNceXJ48dA
has assertion: p(HGNC:GAS1) -| bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.842+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:GAS1) -| bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8127893

3
value: Overexpression of h-gas1 is able to block cell proliferation in the A549 lung carcinoma and the T24 bladder carcinoma cell lines.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8127893

Selventa

RARBtzrq8oufKaitPnOoPHh-3XdSE7kWLW7V0YAjKPofk
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:MSR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.845+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:MSR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8134164

3
value: Immunoelectron microscopy demonstrated that the human macrophage scavenger receptor was expressed after 12-o-tetradecanoylphorbol-13-acetate treatment
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8134164

Selventa

RAWF5Uj9gtMyhXO7SURTKHxfkSmRA2YzJARz8ERRh6yJI
has assertion: kin(p(HGNC:INSR)) -> p(HGNC:PTPN11,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.846+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:INSR)) -> p(HGNC:PTPN11,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8135823

5
value: A full length SH-PTP2 was phosphorylated by insulin receptor kinase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8135823

Selventa

RASdeRNfEWdGWdNJousX8PL9rdIjc 6z- ZY8feMfFY3E
has assertion: a(SCHEM:FSH) -> r(RGD:Tsc22d1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.865+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:FSH) -> r(RGD:Tsc22d1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8161377

3
value: TSC-22 mRNA transiently increased 4-fold in the presence of FSH, reached maximal levels at 3 h, and returned to prestimulation levels by 12 h. The FSH-stimulated increase was independent of protein synthesis because it occurred in the presence of cycloheximide and FSH. TSC-22 mRNA was detected in all tissues examined in male and female rats, and the highest levels in the 16-day animal were observed in the testis, ovary, uterus, and lung.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8161377

Selventa

RAUa22GGKLvVGiT2kBtShoJNMJDRLC0RvsKLSrJsauai0
has assertion: a(SCHEM:FSH) -> r(RGD:Tsc22d1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.867+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:FSH) -> r(RGD:Tsc22d1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/8161377

3
value: TSC-22 mRNA transiently increased 4-fold in the presence of FSH, reached maximal levels at 3 h, and returned to prestimulation levels by 12 h. The FSH-stimulated increase was independent of protein synthesis because it occurred in the presence of cycloheximide and FSH. TSC-22 mRNA was detected in all tissues examined in male and female rats, and the highest levels in the 16-day animal were observed in the testis, ovary, uterus, and lung.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/8161377

Selventa

RAd5ojaP4jDfhSGXpuWjJzlHRxq0zLPDijwFEkfEkbxSQ
has assertion: assertion
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:30:56.870+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234