RAHD7U25NKhesSwYU1fYP-3Q7oiY0HG5o4U 4TyKe-nW4
has assertion: a(SCHEM:Calcium) -> complex(p(HGNC:C1R),p(HGNC:C1S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.321+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> complex(p(HGNC:C1R),p(HGNC:C1S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10092586

BEL Framework Large Corpus Document
description: Approximately 61,000 statements.
rights: Copyright (c) 2011-2012, Selventa. All rights reserved.
authored by: Selventa
version: 1.4

5
value: The Ca2+-dependent interaction between complement serine proteases C1r and C1s is mediated by their alpha regions, encompassing the major part of their N-terminal CUB-EGF-CUB (where EGF is epidermal growth factor) module array.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10092586

RAIjddhz2zURAIvSCQJ1XHvhG4loMPrPwuzkLvJU2kmLE
has assertion: a(CHEBI:"reactive oxygen species") -> r(HGNC:TGFB1I1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.333+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -> r(HGNC:TGFB1I1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10092676

3
value: The Hic-5 protein is encoded by a transforming growth factor-beta1- and hydrogen peroxide-inducible gene, hic-5, and has striking similarity to paxillin, especially in their C-terminal LIM domains.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10092676

RAIbwGLMQTBmPcJuOnyzEePacZaD1bYWLK vngyO--KWA
has assertion: cat(p(HGNC:CD40)) -| bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.335+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CD40)) -| bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10092782

4
value: Following exposure to either CD40-specific mAbs or the soluble trimeric ligand (sCD40L), high responder (HR) lines showed rapid aggregation, activation of NF-kappa B, up-regulation of cell surface markers ICAM-1/CD54 and Fas/CD95, and growth inhibition
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10092782

RAHaiUPC UxxYO4pa8-c LXTjgw6yXX6eCKRhee uDyXc
has assertion: cat(p(HGNC:CD40)) -> tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.337+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CD40)) -> tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10092782

5
value: Following exposure to either CD40-specific mAbs or the soluble trimeric ligand (sCD40L), high responder (HR) lines showed rapid aggregation, activation of NF-kappa B, up-regulation of cell surface markers ICAM-1/CD54 and Fas/CD95, and growth inhibition
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10092782

RAEaACza8GEAnDQCunZg4iLMrkOxIWyoEICCVTh3fI1uc
has assertion: kin(p(MGI:Cdk2)) => p(MGI:Mybl2,pmod(P,T,524))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.344+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Cdk2)) => p(MGI:Mybl2,pmod(P,T,524))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10095772

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10095772

RACSozeWlqrVK2S82yN04S6K0HLddhGR0ZtSy0InldxcY
has assertion: p(HGNC:ARRB1) -| cat(p(PFH:"ADRB Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.358+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ARRB1) -| cat(p(PFH:"ADRB Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10097102

5
value: betaarrestins mediate the desensitization of the beta2-adrenergic receptor (beta2AR) and many other G protein-coupled receptors (GPCRs)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10097102

RAE0qUGqd0c5av25LpXzPoWWpD6c9EMNECABF3CnA60pg
has assertion: p(HGNC:ARRB2) -| cat(p(HGNC:ADRB2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.360+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ARRB2) -| cat(p(HGNC:ADRB2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10097102

5
value: betaarrestins mediate the desensitization of the beta2-adrenergic receptor (beta2AR) and many other G protein-coupled receptors (GPCRs)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10097102

RAB12839wW4A6g0ciDl2k0Fdq9UNa4Z4YQvZynqfUf0SY
has assertion: complex(p(HGNC:PPARG),p(HGNC:RXRA)) -> tscript(p(HGNC:PPARG))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.369+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:PPARG),p(HGNC:RXRA)) -> tscript(p(HGNC:PPARG))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10098492

7
value: (LPL) gene. A conserved DNA recognition element (-171 to -149 bp) within the promoter functions as a transcriptional enhancer when bound by the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2)/retinoid X receptor alpha (RXRalpha) heterodimer
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10098492

RALhbV8-Ocu6tTaw-yB9hCAYTpDIHHEKcMot1WDnP3G24
has assertion: a(SCHEM:Thiazolidinedione) -> r(MGI:Lpl)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.374+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Thiazolidinedione) -> r(MGI:Lpl)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10098492

3
value: Nuclear hormone receptor ligands such as thiazolidinediones [peroxisome proliferator-activated receptors (PPARs)] or hydrocortisone (glucocorticoid receptor) induce LPL transcription, whereas proinflammatory cytokines, such as tumor necrosis factor-, are inhibitory
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10098492

RAMafSBE-tqoRPp-bPIcc3Yy0ecxikPIPON0EJDRwWwsI
has assertion: p(RGD:Calca) -| a(SCHEM:Calcium)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.390+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Calca) -| a(SCHEM:Calcium)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10100926

3
value: Fasted rats received intravenous infusion of PTH and CT with or without gastrin. PTH raised the blood Ca2+ concentration, whereas CT infusion lowered it.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10100926

RAJ5XnRk-eZTYoGMEzSA2RhX815OSMykHWc7 mz9rDxoY
has assertion: cat(p(HGNC:ADORA2B)) -> kin(p(HGNC:MAPK8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.393+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:ADORA2B)) -> kin(p(HGNC:MAPK8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10101031

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10101031

RAC61d8JjJyQtNvKH RBePU85v5CeanZovehhWdRpoYp8
has assertion: cat(p(HGNC:ADORA2A)) -> kin(p(HGNC:MAPK8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.395+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:ADORA2A)) -> kin(p(HGNC:MAPK8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10101031

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10101031

RAMiiCaQ778cKxnl05v8NhSaGQu0 i4jX9MczJ3FckO94
has assertion: p(HGNC:FLI1) -> r(HGNC:CCND2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.399+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:FLI1) -> r(HGNC:CCND2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10102630

4
value: FLI-1 also prevented the rapid downregulation of cyclin D2 and D3 expression normally observed during Epo-induced differentiation and delayed the downregulation of several other genes involved in cell cycle or cell proliferation control.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10102630

RAHPKKyAbRYF9DAMTMWQdK8tqIeAQsCox75vF3VpBRV3g
has assertion: kin(p(MGI:Kdr)) => p(MGI:Kdr,pmod(P,Y,996))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.407+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Kdr)) => p(MGI:Kdr,pmod(P,Y,996))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10102632

5
value: We have previously reported the identification of four autophosphorylation sites on the KDR VEGF receptor. Two of these sites (tyrosines 951 and 996) are located in the receptor's kinase insert domain, and two (tyrosines 1054 and 1059) are located in the catalytic domain
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10102632

RAJkNDolJVTJ9SMwkJ05bocI3b7cH1UwTvurX7zi9o0v0
has assertion: p(HGNC:NGF) -> cat(p(HGNC:CASP1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.445+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> cat(p(HGNC:CASP1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10191321

5
value: # Ariadne: In contrast, caspase-1 is strongly activated by NGF and other injury stimuli, further supporting the association of specific caspases with inflammatory conditions. [Regulation]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10191321

RAP5l0kjufnoR2Js5e8m7pneFGen3XFKO1I8G1l-eVAfU
has assertion: p(RGD:Ngf) -> p(RGD:Casp2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.447+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ngf) -> p(RGD:Casp2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10191321

4
value: Caspase-2 in its pro-form was processed to its intermediate forms and to final active product p14 when treated with NGF. Caspase-2 was preferentially activated 3.5-fold during NGF-induced oligodendrocyte apoptosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10191321

RAALXpFojR07CK tPbT69v8xrLIK-WIk06i7HHQr2chlQ
has assertion: p(RGD:Ngf) -> p(RGD:Casp3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.451+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ngf) -> p(RGD:Casp3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10191321

4
value: NGF treatment resulted in a 6-fold increase in the active form (p18) of the protease, Caspase-3. Thus Caspase-3 was also activated during NGF-induced through p75 neurotrophin receptor mediated oligodendrocyte cell death.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10191321

RALE3Hj7PQWyyXFX RkHf7HaervOvMpxyUuBkzfhD4NvA
has assertion: a(SCHEM:cytokine) -> r(HGNC:IGFBP4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.454+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:cytokine) -> r(HGNC:IGFBP4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10192430

3
value: IGFBP4 expression in myeloma cells may be modulated by cytokines released by stromal cells and T cells in the microenvironment.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10192430

RAAWoNUdSsWU2JymimoEygzti9uIr9x7M6nX8aK-e2aKY
has assertion: a(SCHEM:"serum insulin") -> path(SDIS:"muscle glucose import")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.456+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> path(SDIS:"muscle glucose import")
label: p(HGNC:ADRB2) -> (a(SCHEM:"serum insulin") -> path(SDIS:"muscle glucose import"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

4
value: Desensitization of b-adrenergic receptors by isoproterenol increases insulin-stimulated glucose uptake in white adipocytes
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAKJB8ZX9wF eWIZtiQJU-TkpQonSJk7KX4EH9Iwxdno0
has assertion: kin(p(HGNC:EGFR)) => p(HGNC:GAB1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.458+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:EGFR)) => p(HGNC:GAB1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

5
value: Gab-1 is heavily phosphorylated by the epidermal growth factor receptor, but poorly by the insulin receptor
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAKqrm3UsiLU9SIMgn5W0kJoXXFzz5L9pc8PbaHXfgBgM
has assertion: kin(p(HGNC:INSR)) => p(HGNC:GAB1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.460+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:INSR)) => p(HGNC:GAB1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

5
value: Gab-1 is heavily phosphorylated by the epidermal growth factor receptor, but poorly by the insulin receptor
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAEVlYNvnigORnwm229hlEX eEzgHS3KUd-oYRG2f2X68
has assertion: a(SCHEM:"serum insulin") -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.466+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

3
value: However, in brown adipocytes (Klein, J., and Kahn, C.R., unpublished data) and white adipocytes (123), stimulation of the b-adrenergic receptor decreases insulin-stimulated PI3-kinase activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAC j6tVbiEpeHcmfb-JpqT4YZFNdeDv4VXFgtfCPDzJQ
has assertion: bp(MESHPP:Obesity) negativeCorrelation p(HGNC:IRS1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.480+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(MESHPP:Obesity) negativeCorrelation p(HGNC:IRS1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

3
value: IRS-1-associated tyrosine phosphorylation and PI3-kinase activity is decreased in skeletal muscle and adipocytes both in obesity and type 2 diabetes (109-112)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RABavTuEVAy1LHvha7kamGg6EnTwv1j3Gn7u8k-BgLkDk
has assertion: p(HGNC:IGF1) -> p(HGNC:IRS1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.486+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IGF1) -> p(HGNC:IRS1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

4
value: In smooth muscle cells, blocking ligand occupancy of aVb3 integrin reduces IGF-1-induced IRS-1 phosphorylation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAGxLuFY9rjRWLtyJk37oXnT8N6cAbaGPwX37pc aROlY
has assertion: complex(p(HGNC:IRS1),p(HGNC:ITGAV)) -> (p(HGNC:IGF1) -> p(HGNC:IRS1,pmod(P,Y)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.489+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:IRS1),p(HGNC:ITGAV)) -> (p(HGNC:IGF1) -> p(HGNC:IRS1,pmod(P,Y)))
label: p(HGNC:IGF1) -> p(HGNC:IRS1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

8
value: In smooth muscle cells, blocking ligand occupancy of aVb3 integrin reduces IGF-1-induced IRS-1 phosphorylation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAA5tfJNWKmZL9oDZmcsFLFxP2ZZhJnkAVfu9p37h1hKc
has assertion: a(SCHEM:"serum insulin") -| path(SDIS:"adipocyte lipolysis")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.509+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -| path(SDIS:"adipocyte lipolysis")
label: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> (a(SCHEM:"serum insulin") -| path(SDIS:"adipocyte lipolysis"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

4
value: Inhibition of PI3-kinase activity using a dominant negative mutant (30), or pharmacological agents such as wortmannin or LY294002 (31), abolishes insulin stimulated glucose uptake and inhibits GLUT4 vesicle translocation to the plasma membrane. Many other cellular effects of insulin, such as antilipolysis, activation of fatty acid synthesis, acetyl CoA-carboxylase, glycogen synthase, Akt phosphorylation, glycogen synthase kinase 3b inactivation, and stimulation of protein synthesis and DNA synthesis, are also inhibited by PI3- kinase suppression PIP3, rather than PIP2, is the major mediator of PI3- kinase dependent biological actions of insulin
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RALOufMoEqJ2P29JGgmZPRN9FJteLkETHjK9HPGlwfJkg
has assertion: a(SCHEM:"serum insulin") -> p(HGNC:IRS1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.527+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> p(HGNC:IRS1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

3
value: Insulin and IGF-1 stimulation also promote association between IRS-1 and aVb3 integrin (vitronectin receptor)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAM1J1rm-lS11K037mhkiQNbZtB3RqyAUdDVWAt3f5ugU
has assertion: kin(p(HGNC:INSR)) => p(HGNC:GAB1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.544+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:INSR)) => p(HGNC:GAB1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

5
value: Insulin receptor substrates are a growing family of proteins that are phosphorylated by the activated insulin receptor. To date, nine members of this family have been identified, including IRS-1 (17, 18), IRS-2 (19), IRS-3 (20), and IRS-4 (21), which are generally viewed as the most specific for insulin signaling; Gab-1 (22); Shc, which has three isoforms (23); and p62dok Following insulin binding, the receptor undergoes autophosphorylation on multiple tyrosine residues. This results in activation of the receptor kinase and tyrosine phosphorylation of a family of insulin receptor substrate (IRS) proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAL5Ajs4NRGeMZLaDEv0BKhJc0w TZsmDRBBa-ZNeMRDQ
has assertion: kin(p(MGI:Insr)) => p(MGI:Irs3,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.551+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Insr)) => p(MGI:Irs3,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

5
value: Insulin receptor substrates are a growing family of proteins that are phosphorylated by the activated insulin receptor. To date, nine members of this family have been identified, including IRS-1 (17, 18), IRS-2 (19), IRS-3 (20), and IRS-4 (21), which are generally viewed as the most specific for insulin signaling; Gab-1 (22); Shc, which has three isoforms (23); and p62dok Following insulin binding, the receptor undergoes autophosphorylation on multiple tyrosine residues. This results in activation of the receptor kinase and tyrosine phosphorylation of a family of insulin receptor substrate (IRS) proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAPcBot F Mt-5uVNZkmEr20sRe5b4PTtEWjTJ9n1EcLg
has assertion: bp(MESHPP:Obesity) negativeCorrelation r(HGNC:INSR)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.569+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(MESHPP:Obesity) negativeCorrelation r(HGNC:INSR)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

3
value: Obese human subjects have decreased insulin receptor expression level and tyrosine kinase activity in skeletal muscle (103) and adipocytes (104).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAMCHS6-c7UuGZQJ9qC1tgqvaLARGtwODnWs nOCsWKOg
has assertion: bp(MESHPP:Obesity) negativeCorrelation kin(p(HGNC:INSR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.571+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(MESHPP:Obesity) negativeCorrelation kin(p(HGNC:INSR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

4
value: Obese human subjects have decreased insulin receptor expression level and tyrosine kinase activity in skeletal muscle (103) and adipocytes (104).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAJj0jT1cuv6-U0BrB7 CG6tIOQvhBoKB0GicwpWzTh-I
has assertion: p(HGNC:INSR,pmod(P,Y,960)) => kin(p(HGNC:INSR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.583+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:INSR,pmod(P,Y,960)) => kin(p(HGNC:INSR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

5
value: Phosphotyrosine at site 960 of the b subunit just inside the membrane creates an NPXpY-recognition motif for the PTB domain of the IRS proteins. Modification of this tyrosine completely inhibits subsequent phosphorylation of IRS-1 and other insulin receptor substrates and leads to loss of most insulin-dependent biological actions
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAP 6ibyjHi VQ6i1WnO3sZb1dS-TsAvZkmY88h91OwA0
has assertion: kin(p(HGNC:INSR)) => p(HGNC:IRS1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.591+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:INSR)) => p(HGNC:IRS1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

5
value: Phosphotyrosine at site 960 of the b subunit just inside the membrane creates an NPXpY-recognition motif for the PTB domain of the IRS proteins. Modification of this tyrosine completely inhibits subsequent phosphorylation of IRS-1 and other insulin receptor substrates and leads to loss of most insulin-dependent biological actions
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAK7uTz07eYDkXqTPuO8iKTHUND6KuE7nBG4Afqptw4uY
has assertion: kin(p(HGNC:INSR)) => p(HGNC:IRS4,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.597+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:INSR)) => p(HGNC:IRS4,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

5
value: Phosphotyrosine at site 960 of the b subunit just inside the membrane creates an NPXpY-recognition motif for the PTB domain of the IRS proteins. Modification of this tyrosine completely inhibits subsequent phosphorylation of IRS-1 and other insulin receptor substrates and leads to loss of most insulin-dependent biological actions
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAFi1djoMWhGu54iIWFom- Jm2n6JI3OPASCLcofW4yCE
has assertion: p(HGNC:ITGB1) -> p(HGNC:IRS1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.618+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ITGB1) -> p(HGNC:IRS1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

4
value: Recently, b1 integrins have also been reported to enhance IRS-1 phosphorylation and interaction, but not glucose transport, with downstream molecules such as PI3-kinase and Akt (74). These results suggest that integrins and insulin/IGF-1 receptor signaling pathways converge at an early point in the signaling cascade around the IRS proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAIRyWMdESuFif8sDGcIhfDMGDFJXS3UWKnNyafKgKP8M
has assertion: a(CHEBI:glucosamine) -| (a(SCHEM:"serum insulin") -> kin(complex(NCH:"p85/p110 PI3Kinase Complex")))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.649+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glucosamine) -| (a(SCHEM:"serum insulin") -> kin(complex(NCH:"p85/p110 PI3Kinase Complex")))
label: a(SCHEM:"serum insulin") -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

4
value: The ability of a variety of nutrients to activate the hexosamine pathway has led to the theory that this pathway serves as a general nutrient sensing pathway, through which hyperglycemia or hyperlipidemia could decrease insulin sensitivity of cells when nutrient excess prevails (148). In cell culture, omission of glutamine (a cofactor of GFA) from the media, or addition of glutamine analogues, blunts the desensitizing effect of glucose on insulin sensitivity (150). Glucosamine infusion for two to six hours will decrease insulin-stimulated IRS-1 tyrosine phosphorylation, PI3-kinase activation, and activation of glycogen synthase in a manner that parallels the decrease in insulin-stimulated glucose uptake in skeletal muscle. This effect can be seen both in acute and chronic stimulation with insulin (151) (Patti, M.E., personal communication).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAKkSJXwKiGklk2hNS5WabZcQB-RHDckSzzOfhZBWv1SU
has assertion: a(SCHEM:"serum insulin") -> cat(p(HGNC:GYS2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.655+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> cat(p(HGNC:GYS2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

4
value: The ability of a variety of nutrients to activate the hexosamine pathway has led to the theory that this pathway serves as a general nutrient sensing pathway, through which hyperglycemia or hyperlipidemia could decrease insulin sensitivity of cells when nutrient excess prevails (148). In cell culture, omission of glutamine (a cofactor of GFA) from the media, or addition of glutamine analogues, blunts the desensitizing effect of glucose on insulin sensitivity (150). Glucosamine infusion for two to six hours will decrease insulin-stimulated IRS-1 tyrosine phosphorylation, PI3-kinase activation, and activation of glycogen synthase in a manner that parallels the decrease in insulin-stimulated glucose uptake in skeletal muscle. This effect can be seen both in acute and chronic stimulation with insulin (151) (Patti, M.E., personal communication).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAIqLEGOXCtdST4z GcHXdLciLcarQMwxZxzu4MJD5qlc
has assertion: a(SCHEM:"serum insulin") -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.658+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

3
value: The ability of a variety of nutrients to activate the hexosamine pathway has led to the theory that this pathway serves as a general nutrient sensing pathway, through which hyperglycemia or hyperlipidemia could decrease insulin sensitivity of cells when nutrient excess prevails (148). In cell culture, omission of glutamine (a cofactor of GFA) from the media, or addition of glutamine analogues, blunts the desensitizing effect of glucose on insulin sensitivity (150). Glucosamine infusion for two to six hours will decrease insulin-stimulated IRS-1 tyrosine phosphorylation, PI3-kinase activation, and activation of glycogen synthase in a manner that parallels the decrease in insulin-stimulated glucose uptake in skeletal muscle. This effect can be seen both in acute and chronic stimulation with insulin (151) (Patti, M.E., personal communication).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAFDINSTdmlZnwvfS-Ud ZyuZ1Rv0IMyCRvDh32qweczI
has assertion: a(SCHEM:"serum insulin") -> complex(p(HGNC:FYN),p(HGNC:CBL))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.661+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> complex(p(HGNC:FYN),p(HGNC:CBL))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194465

5
value: c-Cbl is tyrosine-phosphorylated, binds to Fyn upon insulin stimulation, and is translocated to small invaginations of the plasma membrane, called caveolae, after insulin stimulation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194465

RAMtmmy1wLA5Hu6QPtQzkhFb-JUFVwx0Rd8MbuXkK 3Zg
has assertion: kin(p(HGNC:MAPK1)) => p(HGNC:STAT5A,pmod(P,S,780))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.667+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) => p(HGNC:STAT5A,pmod(P,S,780))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194762

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194762

RAGPcB yxASu1A2k93V7TdYJAZjqd5fSTZNjqCTlsz0Kc
has assertion: complex(p(MGI:Elk1),p(MGI:Elk4)) => tscript(p(MGI:Elk1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.672+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(MGI:Elk1),p(MGI:Elk4)) => tscript(p(MGI:Elk1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10194767

7
value: . This region contains three juxtaposed SRE (serum response element)/Ets site pairs known to be important for egr-1 activity in response to exogenous stimuli. Site-specific mutations of individual SRE and Ets sites within this region each reduced GH inducibility of the promoter. Use of these site-specific mutations in EMSA showed that disruption of either Ets or SRE sites abrogated ternary complex formation at the composite sites. DNA binding of ternary complexes, but not binary complexes, in EMSA was rapidly and transiently increased by GH. EMSA supershifts indicated these ternary complexes contained serum response factor (SRF) and the Ets factors Elk-1 and Sap-1a. Coexpression of Sap-1a and Elk-1 resulted in a marked increase in GH induction of egr-1 promoter activity, although transfection with expression vectors for either Ets factor alone did not significantly enhance the GH response.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10194767

RAHlJQKH00UPij 7Sb6JCnAk4DS4veHEin2PV5QJshoZI
has assertion: p(HGNC:IGF1) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.676+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IGF1) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10195934

4
value: Insulin-like growth factor 1 activates only phosphatidylinositol-3 kinase.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10195934

RACZVFFpslpiCopfaOcb48lu 7NuPpSKeAhpmZxmMrfO4
has assertion: p(MGI:Ntrk1) -> p(MGI:Mapk3,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.682+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ntrk1) -> p(MGI:Mapk3,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10195934

4
value: Ngf induced the tyrosine phosphorylation of Erk1 in tyrosine receptor kinase-expressing cells. Erk1 remained phosphorylated for 1 to 4 hours after Ngf treatment. Ngf treatment induced a 6- to 8-fold increase in MAP kinase activity within 5 minutes of treatment and the activity remained elevated up to 4 hours. This indicated that Erk1 phosphorylation was brought about by tyrosine receptor kinase A after treatment with Ngf.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10195934

RAC4THopbuu-nDidXGphlLATz2fYZiD91h9h7ZLeQeSTM
has assertion: p(HGNC:PDGFB) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.685+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PDGFB) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10195934

4
value: The activation of phosphatidylinositol-3 kinase, however, was 10-fold greater in response to PDGF-BB compared with NGF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10195934

RAF9G5ffSA9eWi3T5pD5q4mWX9zw2Dsfi0Rgn3HFWqfGA
has assertion: p(HGNC:NGF) -> bp(GO:"cell migration")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.688+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> bp(GO:"cell migration")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10195934

3
value: The neurotrophin, nerve growth factor (NGF), and insulin-like growth factor 1 induce the migration but not the proliferation of smooth muscle cells, whereas PDGF-BB stimulates both responses.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10195934

RAEdOc3Q29XlnjrSMsb-16Q2Es4miZvT7OUksl23Whf7U
has assertion: cat(p(HGNC:ADRA2C)) -> kin(p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.711+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:ADRA2C)) -> kin(p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10196213

6
value: alpha2-AR-mediated activation of either endogenous or cotransfected p42/p44 mitogen-activated protein (MAP) kinase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10196213

RAIiuheYFpWQA0NCUrhQig31TWjfzKE8dJvisvM9VdktI
has assertion: kin(p(MGI:Mapk1)) -| tscript(p(MGI:Smad2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.719+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Mapk1)) -| tscript(p(MGI:Smad2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10197981

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10197981

RAFc0ym6UphfullB4bEPzpBo -ZvZdysgBUIt8XWx1NV0
has assertion: a(SCHEM:"serum insulin") -| path(SDIS:"adipocyte lipolysis")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.735+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -| path(SDIS:"adipocyte lipolysis")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10199397

2
value: Furthermore, studies of patients with insulin-secreting tumors suggest that inhibition of hepatic glucose production is the major mechanism whereby insulin lowers plasma glucose in the fasting state. Insulin first acts directly upon adipose tissue to suppress lipolysis and decrease levels of circulating free fatty acids. This, in turn, may cause the inhibition of hepatic glucose production
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10199397

RAChttEd1dHKoLYNLJy-JR8 6b2pjsShzD1X3IFVMQyF0
has assertion: a(SCHEM:"serum insulin") -> bp(GO:"glucose transport")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.740+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> bp(GO:"glucose transport")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10199397

2
value: Insulin promotes the deposition of glycogen in liver and triglyceride in adipose tissue, and also activates glucose transport and glycogen synthesis in muscle.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10199397

RAMBsLevDDHfCna3OXIuNR0WNJxwuMRIkIoAaWEOCp2Cs
has assertion: p(MGI:Insr) -> bp(MESHPP:"Insulin Resistance")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.744+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Insr) -> bp(MESHPP:"Insulin Resistance")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10199397

3
value: Skeletal Muscle. Insulin receptor function has been inhibited in two ways: muscle-specific knockout of the insulin receptor (MIRKO; Bruning et al., 1998) and muscle-specific expression of a dominant-negative mutant insulin receptor (IR-A1134T) in transgenic mice (Moller et al., 1996). In both models, skeletal muscle was insulin resistant when studied in vitro.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10199397

RAHzTjHYnpxZPj1GRR9YhsKMTFfX2JkAU cKCH dGSurE
has assertion: kin(p(HGNC:INSR)) => p(HGNC:IRS1,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.749+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:INSR)) => p(HGNC:IRS1,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10199397

5
value: The insulin receptor, a ligand-stimulated tyrosine kinase, mediates the first steps in insulin action (White and Yenush, 1998). The activated receptor phosphorylates multiple proteins-e.g., insulin receptor substrates (IRS)-1, -2, -3, and -4. Phosphorylation of tyrosine residues in these substrates leads to activation of multiple downstream signaling pathways.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10199397

RABX7qnTQXZs-J7b89n3owB0mMatDBRcyqT-U13jYpoaI
has assertion: p(HGNC:CCL11) -> p(HGNC:ICAM1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.774+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CCL11) -> p(HGNC:ICAM1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10201960

4
value: Eotaxin in association with IL-2 and IL-4 up-regulated ICAM-1 expression on T lymphocytes within 8 hours. The ICAM-1 expression was up-regulated to more than 80% by 16 hours and to 97% by 24 hours.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10201960

RAAyKstXctd8JtQjxF3njV02S3nuFNT6bIaLhcYVWNbhc
has assertion: a(SCHEM:"Ro 31-7549") -| kin(p(PFM:"Prkc Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.789+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Ro 31-7549") -| kin(p(PFM:"Prkc Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10202031

4
value: RO31-7549 (protein kinase C (PKC) inhibitor) inhibited activation of PDE4 by PMA.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10202031

RAFGqjlxVGQkeHb8ny5u9KL4qjbnvgdMb0A0zlb-TUQiE
has assertion: a(SCHEM:"AG-490") -| (p(MGI:Il4) -> cat(p(MGI:Pde3b)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.792+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"AG-490") -| (p(MGI:Il4) -> cat(p(MGI:Pde3b)))
label: p(MGI:Il4) -> cat(p(MGI:Pde3b))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10202031

6
value: TNF-alpha, AG-490 (Janus kinase inhibitor), and wortmannin (PI3-K inhibitor) inhibited activation of PDE3 and PDE4 by IL-4. TNF-alpha also blocked IL-4-induced tyrosine phosphorylation of IRS-2, but not of STAT6. AG-490 and wortmannin, not TNF-alpha, inhibited activation of PDE4 by IL-3
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10202031

RALU z6QcNuMguS9C0ZtKH9-sUlpRp 4kGcFI2VRABgxI
has assertion: p(MGI:Il4) -> p(MGI:Irs2,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.794+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Il4) -> p(MGI:Irs2,pmod(P,Y))
label: p(MGI:Tnf) -| (p(MGI:Il4) -> p(MGI:Irs2,pmod(P,Y)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10202031

6
value: TNF-alpha, AG-490 (Janus kinase inhibitor), and wortmannin (PI3-K inhibitor) inhibited activation of PDE3 and PDE4 by IL-4. TNF-alpha also blocked IL-4-induced tyrosine phosphorylation of IRS-2, but not of STAT6. AG-490 and wortmannin, not TNF-alpha, inhibited activation of PDE4 by IL-3
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10202031

RABamrh6pllgMP6j0Io9Z3QgIP14vYsUNzQPVqxAYX8rI
has assertion: a(SCHEM:"PD 98,059") -| (a(SCHEM:"Tetradecanoylphorbol acetate") -> kin(p(PFM:"MAPK Erk1/3 Family")))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.804+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"PD 98,059") -| (a(SCHEM:"Tetradecanoylphorbol acetate") -> kin(p(PFM:"MAPK Erk1/3 Family")))
label: a(SCHEM:"Tetradecanoylphorbol acetate") -> kin(p(PFM:"MAPK Erk1/3 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10202031

5
value: The MAP kinase kinase (MEK-1) inhibitor PD98059 inhibited IL-4-, IL-3-, and PMA-induced activation of MAP kinase and PDE4
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10202031

RAIQh iT4deuES28DdJNcKvH0D5X-V5Tadm0oxFLeDpbM
has assertion: a(CHEBI:haloperidol) -> r(HGNC:JUN)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.813+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:haloperidol) -> r(HGNC:JUN)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10204691

3
value: Haloperidol (0.1-8 mg/kg) and (-)-sulpiride (10-100 mg/kg), induced NGF mRNA in a dose-dependent fashion haloperidol and (-)-sulpiride induce the expression of c-fos and c-jun mRNAs and increase their AP-1 DNA binding activities. Thus, the data suggest that neuroleptics induce NGF gene expression by increasing AP-1 DNA binding activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10204691

RADORYNuUplOPbkdowYP7SZRYKIpNIOPVdywiJ47GaVI8
has assertion: a(CHEBI:haloperidol) -> tscript(complex(NCH:"AP-1 Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.817+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:haloperidol) -> tscript(complex(NCH:"AP-1 Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10204691

3
value: Haloperidol (0.1-8 mg/kg) and (-)-sulpiride (10-100 mg/kg), induced NGF mRNA in a dose-dependent fashion haloperidol and (-)-sulpiride induce the expression of c-fos and c-jun mRNAs and increase their AP-1 DNA binding activities. Thus, the data suggest that neuroleptics induce NGF gene expression by increasing AP-1 DNA binding activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10204691

RAHaSscBDoBV-a0krqNK8Jy5GGf-x432eV5aVr41Xnls4
has assertion: kin(p(HGNC:SRC)) => p(HGNC:RAF1,pmod(P,Y,341))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.823+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:SRC)) => p(HGNC:RAF1,pmod(P,Y,341))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10205168

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10205168

RANeoxCu6dJDMa4vp9RcrUmcqjdCC48UezV87GH5xG1Zk
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Fgf1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.828+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Fgf1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10207015

3
value: In fact, the levels of this particular mRNA are dramatically increased upon phorbol 12-myristate 13-acetate, serum, and transforming growth factor-beta stimulation. These observations point to a more complex mechanism of Fgf1 regulation,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10207015

RALJpL4sm-CFueL2X5rSXfYEDpZ2P190Zf18bbLRx7Cms
has assertion: p(MGI:Myc) -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.862+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Myc) -> bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10207076

3
value: The c-Myc oncoprotein induces cell proliferation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10207076

RAPTGByC-dbiei-Pu15MXwu6XCnlmlqisAvcOpzI-g2mc
has assertion: kin(p(PFH:"PDGFR Family")) -> tscript(p(HGNC:STAT3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.869+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PDGFR Family")) -> tscript(p(HGNC:STAT3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10207096

6
value: We conclude that the mechanisms of activation of Stat1 and Stat3 by PDGFR are distinct. Stat1 activation appears to result from a direct interaction with the receptor, whereas Stat3 activation additionally requires JAK proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10207096

RAJnq92x2r6Yl 6-z5f00BELLFelAnHxW-C6xh4bwOQnc
has assertion: p(HGNC:STAT5B,pmod(P)) => tscript(p(HGNC:STAT5B))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.876+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:STAT5B,pmod(P)) => tscript(p(HGNC:STAT5B))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10209040

5
value: We show here that BCR/ABL induces phosphorylation and activation of STAT5
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10209040

RAHxED4TZ5iUQGQItwQff2O2ri1JpmRGltyjrQqUyj9Ho
has assertion: kin(p(HGNC:SRC)) => p(HGNC:GSN,pmod(P,Y,465))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.882+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:SRC)) => p(HGNC:GSN,pmod(P,Y,465))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10210201

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10210201

RAMdZ679YmlymHnabz5EHbHvzrY9KzfH1KrB1OEfQo 6s
has assertion: tscript(p(HGNC:PRRX1)) => tscript(p(HGNC:SRF))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.896+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:PRRX1)) => tscript(p(HGNC:SRF))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10212268

6
value: In addition, Phox1 and Elk-1 potentiate the ability of SRF to transcriptionally activate the c- fos promoter in response to growth-mediated events ( 18 ).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10212268

RAK4NSFiOSagc2nwqRTEPZE-zEqT6DXnLjaeXmIUMRR4Q
has assertion: kin(p(HGNC:MAPK1)) -> p(HGNC:EIF4E,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.905+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) -> p(HGNC:EIF4E,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10212283

5
value: PGF2alpha also induced eIF4E and 4E-BP1 phosphorylation, global protein synthesis and basic fibroblast growth factor-2 (bFGF-2) expression in VSMC
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10212283

RAL11o3JgH79j VD48Vu91xHz6uLgEzxpeWJ2JH23YEb4
has assertion: a(CHEBI:androgen) -> r(HGNC:CALR)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.916+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:androgen) -> r(HGNC:CALR)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10213498

3
value: Androgen treatment upregulates the calreticulin expression in LNCaP cells. Androgen treatment time for inducing calreticulin mRNA in LNCaP cells was 36 hour in the presence of CHX and anisomycin. Similar to mRNA protein levels of calreticulin was also regulated by androgen.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10213498

RAF9Fjz5mbR1Sste8j9YzL sPdkuqQr4FfomsCbDPuSTU
has assertion: p(HGNC:BTC) => kin(complex(p(HGNC:EGFR),p(HGNC:ERBB2)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.920+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:BTC) => kin(complex(p(HGNC:EGFR),p(HGNC:ERBB2)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10214951

7
value: Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10214951

RADeG3ZtfidOPHa-jccoSGSVWVbLMOB5hi5FMjcQDzAPc
has assertion: p(HGNC:EGF) => complex(p(HGNC:ERBB4),p(HGNC:ERBB2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.925+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) => complex(p(HGNC:ERBB4),p(HGNC:ERBB2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10214951

6
value: Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10214951

RAErw5i8MFzkU16uu3kDatZgpMurxb7s7wBfoyU3U8gb4
has assertion: p(HGNC:HBEGF) => complex(p(HGNC:EGFR),p(HGNC:EGFR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.930+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:HBEGF) => complex(p(HGNC:EGFR),p(HGNC:EGFR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10214951

6
value: Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10214951

RAKsnF0ePWcUic-g dIV-hz5t3ityVoT02Rwo6JMnNMjg
has assertion: p(HGNC:HBEGF) => complex(p(HGNC:EGFR),p(HGNC:ERBB2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.932+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:HBEGF) => complex(p(HGNC:EGFR),p(HGNC:ERBB2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10214951

6
value: Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10214951

RAMrA7VBJYE1xqZVm1XsTQFrKjqLk864D8saZMlcvjV0Q
has assertion: p(HGNC:NRG1) => kin(complex(p(HGNC:ERBB4),p(HGNC:ERBB4)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.941+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NRG1) => kin(complex(p(HGNC:ERBB4),p(HGNC:ERBB4)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10214951

7
value: Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10214951

RABd4WOgjILiGHa1Kfwh7GptOX64l3Fix5WZSQsAwSnQM
has assertion: complex(p(HGNC:EGFR),p(HGNC:ERBB2)) => kin(complex(p(HGNC:EGFR),p(HGNC:ERBB2)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.947+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:EGFR),p(HGNC:ERBB2)) => kin(complex(p(HGNC:EGFR),p(HGNC:ERBB2)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10214951

9
value: Table 2: Classification of ligands according to their relative affinities toward ErbB-IgGs. I only too the High affinity (1-100 nM) and Very high affinity (<1 nM).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10214951

RAM1r 68uP676yUWxOGpbpf1Malb2yQCQuykbIEMgTy5w
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| tscript(p(HGNC:FOXO4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.951+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| tscript(p(HGNC:FOXO4))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10217147

5
value: To investigate whether PI(3)K and protein kinase B (PKB) were involved in insulin-induced phosphorylation of AFX, we co-expressed HA±AFX with active forms of PI(3)K or PKB. Constitutively active, but not inactive, forms of PI(3)K or PKB induced a strong increase in HA±AFX phosphorylation (Fig. 1c).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10217147

RAGb1c4gT8XNSHZky6i9e4jGWDnnu XfAnrD4dKwi5G2M
has assertion: p(MGI:Il6st) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.960+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Il6st) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10219240

3
value: Such conditional mutant mice (knockout of wild type IL6ST under the Cre-Lox system) have normal cardiac structure and function, but during aortic pressure overload, these mice display rapid onset of dilated cardiomyopathy and massive induction of myocyte apoptosis versus the control mice that exhibit compensatory hypertrophy.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10219240

RABO27AlcCKN0A5R0pygPi9jZ88H4e5WYmg-1QwY8OPp4
has assertion: p(HGNC:NGF) -> r(HGNC:MAG)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.966+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:MAG)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10221670

4
value: Nerve growth factor (NGF) upregulated expression of the MAG binding molecule in a dose dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10221670

RAGCQQ5eFZLZFGRQ7vOQWlUimqaTQHzI7c26mCx6fnHPY
has assertion: cat(p(RGD:Agtr1b)) -> tscript(p(RGD:Stat1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.973+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr1b)) -> tscript(p(RGD:Stat1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10222333

6
value: stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10222333

RAJoUppoOKczKxEbzhG5YgzXEoJ04xLB3FD2RqCp71FKg
has assertion: cat(p(RGD:Agtr1b)) -> tscript(p(RGD:Stat2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.975+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr1b)) -> tscript(p(RGD:Stat2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10222333

6
value: stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10222333

RAKlW1PdwdvoawndyJNuUw6n4p 2pVlUwNXeORrbMXdD0
has assertion: cat(p(RGD:Agtr2)) -| cat(p(RGD:Agtr1b))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.984+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr2)) -| cat(p(RGD:Agtr1b))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10222333

6
value: stimulation of AT2 receptor in AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells (VSMCs) inhibited angiotensin II type 1 (AT1) receptor-mediated tyrosine phosphorylation of STAT (signal transducers and activators of transcription) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10222333

RAFm9Q8HdFXZ3Rfl5pal-4DXiU3paPvDUKMe1suTuhsd4
has assertion: path(SDIS:"bacterial infection") -> r(MGI:Msr1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.989+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"bacterial infection") -> r(MGI:Msr1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10223745

3
value: The administration of LPS, zymosan, BCG, or L. monocytogenes to mice resulted in ... the upregulation of MSR-A expression in the liver and spleen
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10223745

RAPEbulBvCdRHx9lqBLpifWj46pbgOPiSvRxf02V7KqGQ
has assertion: kin(p(PFH:"AKT Family")) => p(HGNC:TERT,pmod(P,S,227))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.992+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"AKT Family")) => p(HGNC:TERT,pmod(P,S,227))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10224060

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10224060

RAB1-Gt-ZWl2pQrU7iQjvg5LXnKZClJcmU2bnZUzgWG14
has assertion: phos(p(HGNC:DUSP3)) -| kin(p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.997+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(HGNC:DUSP3)) -| kin(p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10224087

6
value: Subsequent kinetic analyses and transfection studies demonstrated that VHR specifically dephosphorylates and inactivates ERK1 and ERK2 in vitro and in vivo.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10224087

RAKeMCgnH5xDpyb1PcXwRKNa4s3EThSQimuvwaIai8Iec
has assertion: path(SDIS:"tissue damage") -> r(HGNC:NACA)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:46.998+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"tissue damage") -> r(HGNC:NACA)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10224091

3
value: we identified a gene that was strongly induced as early as 12 h after wounding. Sequence analysis revealed the identity of the corresponding protein with skeletal muscle nascent polypeptide-associated complex (skNAC)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10224091

RAItJQroQE7mWVDYRY0Fy6 IEHdIGA2hsGCc4Y8MLk4WA
has assertion: p(RGD:Ghr) -> p(RGD:Jak2,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.000+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ghr) -> p(RGD:Jak2,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10224108

4
value: H4 cells were treated with 500ng/ml of bovine growth hormone for 10 minutes. It was observed that a fraction of the immunoprecipitated JAK2 had been phosphorylated on tyrosine residues. Insulin (100 Nm) pretreatment for 16 hours, significantly inhibited the ability of bGH to induce tyrosine phosphorylation of immunoprecipitated JAK2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10224108

RAB8BN-F vN4K1CaqZlBvSJpXRPjkVhbF8l2eMmOyTFJU
has assertion: tport(p(MGI:Fabp3)) -| path(SDIS:"cardiomyocyte hypertrophy")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.006+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tport(p(MGI:Fabp3)) -| path(SDIS:"cardiomyocyte hypertrophy")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10224224

4
value: H-FABP deficiency is only incompletely compensated, however, causing acute exercise intolerance and, at old age, a localized cardiac hypertrophy
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10224224

RAGu46mda0tzo2vKaO7z6wJN6m9jJ7m-4p4n99g b7eiw
has assertion: p(HGNC:FGF1) -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.010+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:FGF1) -> bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10226073

3
value: Acidic fibroblast growth factor (FGF-1), a prototype member of the heparin-binding growth factor family, influences proliferation, differentiation, and protein synthesis in different cell types
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10226073

RACxHmblTEsYowaydIHPdEIFvX Je92mmYGUZVoVEITQk
has assertion: p(HGNC:IL4) -> p(HGNC:TFRC)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.013+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL4) -> p(HGNC:TFRC)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10227975

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10227975

RADYBuukb8xhKtrIs4lxT7GBwZMxF5NA26-sgzPhtK7Jg
has assertion: p(HGNC:IFNB1) -> kin(p(HGNC:JAK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.024+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IFNB1) -> kin(p(HGNC:JAK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10228162

5
value: Receptor stimulation results in the activation of distinct combinations of Janus family protein tyrosine kinases (Jak PTKs); Jak1/Tyk2 and Jak1/Jak2 for IFN-alpha/beta and IFN-gamma, respectively.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10228162

RAIdEig-WX UlOnZUbBUeJTK2 cmveWv9tu7fmt2ZmM5s
has assertion: p(HGNC:IFNB1) -> kin(p(HGNC:JAK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.026+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IFNB1) -> kin(p(HGNC:JAK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10228162

5
value: Receptor stimulation results in the activation of distinct combinations of Janus family protein tyrosine kinases (Jak PTKs); Jak1/Tyk2 and Jak1/Jak2 for IFN-alpha/beta and IFN-gamma, respectively.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10228162

RACbig5DK13GXiu38Bb95EnuSdYMdMUkQo-2b6PBJnfR8
has assertion: p(HGNC:IFNG) -> kin(p(HGNC:JAK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.029+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IFNG) -> kin(p(HGNC:JAK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10228162

5
value: Receptor stimulation results in the activation of distinct combinations of Janus family protein tyrosine kinases (Jak PTKs); Jak1/Tyk2 and Jak1/Jak2 for IFN-alpha/beta and IFN-gamma, respectively.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10228162

RAGJvgLdgrEEzYFQbjZYBAAeGUb-Qq3GvUqqfugJRfbCc
has assertion: p(HGNC:IFNG) -> kin(p(HGNC:TYK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.030+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IFNG) -> kin(p(HGNC:TYK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10228162

5
value: Receptor stimulation results in the activation of distinct combinations of Janus family protein tyrosine kinases (Jak PTKs); Jak1/Tyk2 and Jak1/Jak2 for IFN-alpha/beta and IFN-gamma, respectively.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10228162

RANo-f1zCYfWY5ECc0t2st3LMkJJ2VdnZ3to8vU88B3p0
has assertion: cat(p(HGNC:CD40)) -> kin(complex(NCH:"IkappaB Kinase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.037+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CD40)) -> kin(complex(NCH:"IkappaB Kinase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10229103

5
value: This study demonstrates that the engagement of CD40 results in the activation of the recently described IkappaB kinase (IKK) in a human B cell line
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10229103

RAGlgZPhCxnMqvhCSvNThGemM1HydAb0FmmrO6C4HMwo0
has assertion: p(HGNC:TXN) -> tscript(p(HGNC:NR3C1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.040+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TXN) -> tscript(p(HGNC:NR3C1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10232049

5
value: cellular treatment with H2O2 negatively modulates GR function and decreases glucocorticoid-inducible gene expression. Impaired cellular response to glucocorticoids is rescued by overexpression of TRX, most probably through the functional replenishment of the GR. Moreover, not only the ligand binding domain but the DNA binding domain of the GR is also suggested to be a direct target of TRX.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10232049

RAFS3wCxwySjwLDR8p6dLjEiE8kZ6Tb6QoPdFUIGbd4IQ
has assertion: p(HGNC:TGFB1) -> p(HGNC:DPT)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.041+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TGFB1) -> p(HGNC:DPT)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10233760

4
value: Transforming growth factor-beta1 increased dermatopontin mRNA and protein levels, while interleukin-4 reduced dermatopontin expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10233760

RADIOtOiaxaGJwRot2-xo0b2bStEfATuPG9SGpPv1BZqw
has assertion: phos(p(HGNC:PTPRF)) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.064+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(HGNC:PTPRF)) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10320483

4
value: The over-expression of LAR in mammalian tissue culture cells does not affect cell adhesion but induces caspase-dependent apoptosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10320483

RACde4F8Xbf68wpPQV9eY-JbvpRmrL4EdqHBlRRlD9EXM
has assertion: p(HGNC:BCAR1,pmod(P,Y)) -> p(HGNC:BCAR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.066+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:BCAR1,pmod(P,Y)) -> p(HGNC:BCAR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10320483

4
value: The over-expression of LAR in tissue culture cells specifically decreased the steady state protein level of p130Cas, a multifunctional signal assembly protein in signal transduction, by reducing the tyrosine phosphorylation and protein stability of p130Cas.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10320483

RADxdYs0Tg8t4EJjTWq7E-5ZV4tvtCkNrv 42ELNSzqsE
has assertion: phos(p(HGNC:PTPRF)) -| p(HGNC:BCAR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.067+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(HGNC:PTPRF)) -| p(HGNC:BCAR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10320483

5
value: The over-expression of LAR in tissue culture cells specifically decreased the steady state protein level of p130Cas, a multifunctional signal assembly protein in signal transduction, by reducing the tyrosine phosphorylation and protein stability of p130Cas.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10320483

RAD4m8Oiub1rcqixnegkB3TKjEfM1LvDo3hNMU6gZqFr8
has assertion: a(CHEBI:"nitric oxide") => cat(complex(NCH:"GUCY1 Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.069+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") => cat(complex(NCH:"GUCY1 Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10320667

3
value: sGC is a hemoprotein; it is through the specific interaction of NO with the sGC heme that sGC is activated.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10320667

RAPrrw5C6ABNFeTF5-PLSisAazxUaJhGs6QeHl8ITZfFc
has assertion: bp(GO:"cell differentiation") -> r(HGNC:TGM1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.077+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"cell differentiation") -> r(HGNC:TGM1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10321835

3
value: Expression of the transglutaminase type1 gene (TGM1), which encodes an epithelial cell-specific protein cross-linking enzyme, is limited to particular stages of epidermal development and keratinocyte differentiation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10321835

RAN0MWJXHsGodqXMg7zQKoJr4TYi w0rHlbMaIfVLphf8
has assertion: path(SDIS:"G0 phase of mitotic cell cycle") => tscript(p(PFM:"Mef2 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.081+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"G0 phase of mitotic cell cycle") => tscript(p(PFM:"Mef2 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10322110

4
value: Because our results indicated that the combination of MEF2C-VP16 and E2F1-pRb(SP) could support the activity of MCK-reporter constructs as efficiently as could pRb, we further evaluated the ability of these two proteins to synergistically activate the expression of endogenous muscle genes. In pRb-deficient fibroblasts, MyoD transfection by itself induced low amounts of MHC expression and little or no detectable MCK (Figure 5a-c). In contrast, cells transfected with both MyoD and pRb produced high levels of MHC and MCK (Figure 5d-f). Cotransfection of MyoD with either MEF2C-VP16 or E2F1-pRb(SP) alone led to a relatively small increase in the intensity of MHC staining and low amounts of endogenous MCK expression (Figure 5g-l). However, the combination of MyoD, MEF2C-VP16, and E2F1-pRb(SP) produced cells that expressed very high levels of both MHC and MCK (Figure 5m-o), again mimicking the phenotype of cells transfected with MyoD and pRb. In summary, these results indicate that the ability of pRb to promote muscle differentiation can be fully substituted by the combination of E2F1-pRb(SP) and MEF2C-VP16, suggesting that the requirement for pRb to promote expression of late muscle-differentiation markers reflects the ability of this molecule both to arrest cells in G0 and to potentiate MyoD-mediated activation of the MEF2 TAD.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10322110

RAOkiQeS54ptPHeJxwOvhFYwYkELwDnE052YDfouuP2vE
has assertion: p(MGI:Mef2c,pmod(P,S,387)) => tscript(p(MGI:Mef2c))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.084+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Mef2c,pmod(P,S,387)) => tscript(p(MGI:Mef2c))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10322110

5
value: Because these residues are required for enhanced MEF2C activity in monocytic cells, we tested whether MyoD activation of Gal4-MEF2C required the same amino acids. The combined mutation of both Thr293 and Thr300 to alanine (T293;300A) did not affect the basal activity of Gal4-MEF2C (Figure 3b, compare columns 3 and 5), but did enhance the activity of Gal4-MEF2C when MyoD+E12 were co-expressed (Figure 3b, compare columns 4 and 6). In contrast, mutation of Ser387 to alanine (S387A) decreased the basal activity of Gal4-MEF2C and completely eliminated its activation by co-transfected MyoD+E12 (Figure 3b, columns 7,8). Importantly, activation of the p38 kinase pathway did stimulate the function of the S387A Gal4-MEF2C mutant (data not shown; see also [25,27]), indicating that this mutation does not simply inactivate the protein. Therefore, MyoD activation of the MEF2C TAD requires Ser387, but neither Thr293 nor Thr300, of MEF2C.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10322110

RAHuRjMdvLvybWuWsQurF3G5zCOhbv0Jqg9W yV ZM2a0
has assertion: complex(p(MGI:Myod1),p(MGI:Tcf3)) -> tscript(p(PFM:"Mef2 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.086+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(MGI:Myod1),p(MGI:Tcf3)) -> tscript(p(PFM:"Mef2 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10322110

7
value: Gal4-MEF2C alone weakly activated a co-transfected Gal4-reporter construct, but the inclusion of MyoD and E12 increased this activity at least 10-fold (Figure 3b, compare columns 3 and 4). In 10T1/2 cells, activation of MEF2 reporter constructs was maximally enhanced by the co-expression of MyoD with E12 (data not shown); we therefore included exogenous E12 in this and in subsequent experiments.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10322110

RAATZRxE 0WP6DlqvWvbAUCkjmDg6PsmgvzffRKgveRYY
has assertion: p(MGI:Rb1) -| bp(GO:"cell cycle")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.098+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Rb1) -| bp(GO:"cell cycle")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10322110

3
value: The retinoblastoma tumor-suppressor protein (pRb) plays a critical role in establishing the G0 arrest observed in differentiated myocytes; muscle cells lacking pRb fail to exit the cell cycle and are susceptible to apoptotic cell death [10-13].
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10322110

RAEvGhvX3l-zb 4yjgB7jr24wApxfcoWYboGoMH4F0 rw
has assertion: a(CHEBI:"linoleic acid") -> tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.109+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"linoleic acid") -> tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10325246

3
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10325246

RAMrp9AS8cdBpztynlCvY3ArKAlV345jXQVLJV1OH-kLE
has assertion: tscript(p(PFH:"E2F Family")) => r(HGNC:MCM5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.111+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(PFH:"E2F Family")) => r(HGNC:MCM5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10327050

5
value: Our results demonstrated that the growth-regulated expression of mammalian MCM5 and MCM6 genes, and presumably other MCM members, is primarily regulated by E2F through binding to multiple E2F sites in the promoters.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10327050

RAGAm4YXWib5xxUFDGwqey5jZskvyju3Hj-TWgZ1OVHsQ
has assertion: tscript(p(PFH:"E2F Family")) => r(HGNC:MCM6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.112+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(PFH:"E2F Family")) => r(HGNC:MCM6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10327050

5
value: Our results demonstrated that the growth-regulated expression of mammalian MCM5 and MCM6 genes, and presumably other MCM members, is primarily regulated by E2F through binding to multiple E2F sites in the promoters.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10327050

RAFhyAtg0VDQhIW0t7gMgTo5lhf7htSHzbLJenWOc8nBI
has assertion: a(SCHEM:"cyclic AMP") -> r(RGD:Pld1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.115+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -> r(RGD:Pld1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10327185

3
value: The rPLD1b mRNA increased within 6 h following dbcAMP treatment and maintained a high level up to 24 h.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10327185

RAIQpjPFfU5ZtZKKtMOTXVN1mCPxtgQU-qxR qDDuM00
has assertion: a(CHEBI:"nitric oxide") -> r(HGNC:FAS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.118+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> r(HGNC:FAS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10329044

3
value: Endogenously produced NO, by IFN-gamma pretreatment or exogenous nitrodonors, resulted in the upregulation of Fas receptor mRNA
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10329044

RAA9l3tv gcvwNKkrI2bSqMxJgMUhlLaNEJ4utpk iX8
has assertion: a(SCHEM:"cyclic AMP") -> r(HGNC:MMP2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.125+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -> r(HGNC:MMP2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10329442

3
value: Here we demonstrate that the expression of the human MMP-2 gene is enhanced by a synergistic action of retinoic acid (RA) and dibutyryl cyclic AMP
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10329442

RAK-WPoe4EBy4UUS8IcpDOiWnzjFSuGfW4MkBdqnMxgtA
has assertion: p(HGNC:FGF7) -| (path(MESHD:Hyperoxia) -> r(HGNC:BAX))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.132+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:FGF7) -| (path(MESHD:Hyperoxia) -> r(HGNC:BAX))
label: path(MESHD:Hyperoxia) -> r(HGNC:BAX)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10329601

5
value: The induction of p53, Bax, and Bcl-x mRNAs during hyperoxia was to a large extent prevented by KGF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10329601

RAMagGL761DP1XX hSuZS4F76yujAJ5klkY4EcV4cDAOY
has assertion: p(HGNC:FGF7) -| (path(MESHD:Hyperoxia) -> r(HGNC:TP53))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.134+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:FGF7) -| (path(MESHD:Hyperoxia) -> r(HGNC:TP53))
label: path(MESHD:Hyperoxia) -> r(HGNC:TP53)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10329601

5
value: The induction of p53, Bax, and Bcl-x mRNAs during hyperoxia was to a large extent prevented by KGF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10329601

RAP6tg wl7OrpJh47007G7ol5S6C4uSduSFd5EUtho2UA
has assertion: path(MESHD:Hyperoxia) -> r(HGNC:TP53)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.139+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Hyperoxia) -> r(HGNC:TP53)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10329601

3
value: The induction of p53, Bax, and Bcl-x mRNAs during hyperoxia was to a large extent prevented by KGF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10329601

RAIvMV DddWqc8bnnGNqj1ArcuzigsDY4n5minX8Rfzic
has assertion: p(HGNC:NFKBIA) -> cat(p(HGNC:NOD1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.143+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NFKBIA) -> cat(p(HGNC:NOD1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10329646

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10329646

RADQWqWfPr-BQsjG2WBMShNagA34UjDcac-usmr9lJ0hM
has assertion: kin(p(HGNC:PTK2B)) -> kin(p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.176+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PTK2B)) -> kin(p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10329689

6
value: the Grb2/Sos complex connects Pyk2 to the activation of ERK, whereas adaptor proteins p130Cas and Crk link Pyk2 with the JNK pathway.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10329689

RACiosVjsDf oBP2rNM-X6PNLpP9rUdXGdJKKD5ykKt E
has assertion: complex(p(HGNC:RFX3),g(HGNC:IL5RA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.183+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:RFX3),g(HGNC:IL5RA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10330134

3
value: Using an electrophoretic mobility shift assay, we further show that RFX1, RFX2, and RFX3 homodimers and heterodimers specifically bind to the cis element of the IL-5Ralpha promoter.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10330134

RAJowFZw49HskPV4Kdn9NdvuJF2QIdfNhtbqWgZWm-93Q
has assertion: kin(p(HGNC:MAPK1)) => p(HGNC:ERF,pmod(P,S,161))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.184+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) => p(HGNC:ERF,pmod(P,S,161))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10330152

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10330152

RAPfIw4vawTRTEQ2kUqmRJXDUJNDu7CxuH82JLd73quos
has assertion: kin(p(RGD:Prkcd)) -> kin(p(RGD:Raf1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.190+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(RGD:Prkcd)) -> kin(p(RGD:Raf1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10330161

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10330161

RAHpPEfvTGwf2Vw1VA05Fd8jAJkMEiW9sLX8E9Zlz83c0
has assertion: cat(p(HGNC:CHRM1)) -> tscript(p(HGNC:MEF2C))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.194+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CHRM1)) -> tscript(p(HGNC:MEF2C))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10330169

6
value: # Ariadne: The transactivation domains of MEF2A and MEF2C are activated by m1 G protein-coupled receptors. [Regulation]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10330169

RAPunN74xflWf-AsO9hMRu2slw40PsqOFjbheLuG1LcGQ
has assertion: p(HGNC:TRIM28) -> bp(GO:"chromatin silencing")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.196+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TRIM28) -> bp(GO:"chromatin silencing")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10330177

3
value: Mapping of the region in KAP-1 required for HP1 interaction showed that amino acid substitutions which abolish HP1 binding in vitro reduce KAP-1 mediated repression in vivo.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10330177

RADCBhT6ST8dlOxu81ZWUtcxaWGS0fld9Ki9OzkthpdIQ
has assertion: kin(p(PFH:"PRKC Family")) -| r(HGNC:TNFSF13B)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.205+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -| r(HGNC:TNFSF13B)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10331498

5
value: TALL-1 expression is dramatically down-regulated by phorbol myristate acetate/ionomycin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10331498

RANd2QDAR5Ib1RQMaL7g66UDikq34F-AZifZ-drw3RKfw
has assertion: a(CHEBI:lipopolysaccharide) -> a(CHEBI:"hydrogen peroxide")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.211+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> a(CHEBI:"hydrogen peroxide")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10334819

2
value: LPS treatment increased vascular O2- (from 35+/-2 cpm/ring at baseline to 166+/-21 cpm/ring at 12 hours and 225+/-16 cpm/ring at 30 hours) and H2O2 formation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10334819

RAAytRFaaW2asc3J8E-ByoBt9xq0Ym5Y3oarLw99UHMps
has assertion: a(CHEBI:"lithocholic acid") -> tscript(p(MGI:Nr1h4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.215+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"lithocholic acid") -> tscript(p(MGI:Nr1h4))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10334993

4
value: physiological concentrations of free and conjugated chenodeoxycholic acid, lithocholic acid and deoxycholic acid activated Fxr, an orphan nuclear receptor as ligands, these bile acids and their conjugates modulated interaction of Fxr with a peptide derived from steroid receptor coactivator 1 these results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10334993

RAGHpV15krnyyBRZsF50YvsnkBPAFx9oIbiGYKRTX8vsU
has assertion: kin(p(PFH:"PRKA Family")) -> r(HGNC:CKB)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.240+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKA Family")) -> r(HGNC:CKB)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10340745

5
value: transcription of brain creatine kinase (CKB) mRNA in U87-MG glioblastoma cells is stimulated by a forskolin-mediated increase in cyclic AMP (cAMP) via a pathway involving protein kinase A (PKA)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10340745

RAKlltkhMICbbC2tgxo9RU16XFuQM yVPQSh7fIwzjbu0
has assertion: p(HGNC:MAPK14,pmod(P,T,180)) => kin(p(HGNC:MAPK14))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.272+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MAPK14,pmod(P,T,180)) => kin(p(HGNC:MAPK14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10354710

5
value: MAP kinases help to mediate diverse processes ranging from transcription of protooncogenes to programmed cell death. More than a dozen mammalian MAP kinase family members have been discovered and include, among others, the well studied ERKs and several stress-sensitive enzymes. MAP kinases lie within protein kinase cascades. Each cascade consists of no fewer than three enzymes that are activated in series. Cascades convey information to effectors, coordinates incoming information from other signaling pathways, amplify signals, and allow for a variety of response patterns. Subcellular localization of enzymes in the cascades is an important aspect of their mechanisms of action and contributes to cell-type and ligand-specific responses. Recent findings on these properties of MAP kinase cascades are the major focus of this review.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10354710

RABEWFjEu9suZAO co8TsDGwHNrBFbm5XveCun2Gjn1ec
has assertion: tscript(p(HGNC:HOXC6)) -> r(HGNC:NCAM1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.278+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:HOXC6)) -> r(HGNC:NCAM1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10356360

5
value: We now show that in osteoblast-like cells, rhBMP-2 inhibits NCAM expression, while HOXC6 increases its expression, both acting via the same region of the promoter.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10356360

RAAJnnNCOQtkiMjHxtlwdfeGNuj0rjkzaeUOEYhkWyvoM
has assertion: p(HGNC:CSF1) -> p(HGNC:FYN,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.280+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CSF1) -> p(HGNC:FYN,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10356364

4
value: The Src tyrosine kinases c-Src, c-Yes, c-Fyn, and c-Hck were tyrosine phosphorylated in the M1/WT cells in response to CSF-1 and bound to the WT CSF-1R through their SH2 domains.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10356364

RAAROz8IPWFJyYCjfGaJnklWZf39a5 LjpHKjpJW9HlAs
has assertion: p(HGNC:CSF1) -> p(HGNC:SRC,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.283+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CSF1) -> p(HGNC:SRC,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10356364

4
value: The Src tyrosine kinases c-Src, c-Yes, c-Fyn, and c-Hck were tyrosine phosphorylated in the M1/WT cells in response to CSF-1 and bound to the WT CSF-1R through their SH2 domains.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10356364

RANsszSsA9aY8tXsBuKcfVoyfYQuM2EV4rAWcv8u0H8ac
has assertion: tscript(p(HGNC:FOXO1)) => r(HGNC:IGFBP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.290+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:FOXO1)) => r(HGNC:IGFBP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10358076

5
value: Reporter gene studies in HepG2 hepatoma cells show that FKHR stimulates insulin-like growth factor-binding protein-1 promoter activity through an IRS, and introduction of IRSs confers this effect on a heterologous promoter.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10358076

RAOY72HlGD1v9- 2SxY9oeJBD2zFhkmsQwIaCfmGnb8Rw
has assertion: kin(p(MGI:Map2k1)) -> p(MGI:Fosl2,pmod(P,T))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.300+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Map2k1)) -> p(MGI:Fosl2,pmod(P,T))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10359014

5
value: Ariadne: Thus, the major components of the AP-1 in MEK-DD-transformed CEFs were shown to be Fra-2 and c-Jun, and Fra-2 was highly phosphorylated, as reported in CEFs transformed by v- src , Ha- ras , and activated raf (17 , 22) . [Regulation] Here, we report that the transcriptional activity of Fra-2/c-Jun heterodimer was greatly enhanced by cotransfecting a constitutively active mutant of MEK1 gene (MEK-DD) into F9 cells, indicating that Fra-2 was converted into an active transactivator after phosphorylation by MAPK.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10359014

RAGLcBlIVQ9WCElEj8YIN 67c94Sjb8E3MaP7wYn5cz c
has assertion: tscript(complex(NCM:"AP-1 Complex")) => r(MGI:Fosl2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.302+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCM:"AP-1 Complex")) => r(MGI:Fosl2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10359014

4
value: High-level expression of MEK-DD alone was sufficient to induce clear cellular transformation of chicken embryo fibroblasts, which caused constitutive activation of endogenous MAPK, hyperphosphorylation of Fra-2, and elevation of fra-2 and c-jun gene expression. These results indicate that phosphorylation of Fra-2 by MAPK plays an important role in stimulating endogenous AP-1 activity in a positive autoregulation mechanism, in which phosphorylated Fra-2 induces fra-2 expression through AP-1 binding sites present in its promoter.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10359014

RAF2lUKkq-eHp9k-lxLGmAhJ7dt7Krbkl0mXop7uy LXE
has assertion: p(HGNC:TNF) -> complex(p(HGNC:TNFRSF1A),p(HGNC:GRB2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.303+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> complex(p(HGNC:TNFRSF1A),p(HGNC:GRB2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10359574

6
value: The TNFR-I/Grb2 interaction is essential for the TNF-alpha-dependent activation of c-Raf-1 kinase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10359574

RAD8mWBoBoJqvuSGgngigZhMah560vxQO5wp2utGHMvWk
has assertion: p(MGI:Notch1) -> p(MGI:Hes1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.315+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Notch1) -> p(MGI:Hes1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10359821

4
value: Notch1 activates Hes1 promoter, a downstream target of the notch signaling pathway. Activation of Hes1 promoter was reduced by 70% in PS1-KO cells relative to PS1-wt cells, suggesting that PS1 potentiates Notch1 signaling activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10359821

RANQIoESlPaf0D KxbNB1M2hy6u5SsW6wNSu0kin4WAp4
has assertion: p(MGI:Lif) -> tscript(p(MGI:Stat1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.316+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Lif) -> tscript(p(MGI:Stat1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10359822

5
value: A STAT-1/STAT-3 binding element, located at nucleotides -72 to -64, was essential for LIF stimulation of SOCS-3 promoter activity. Electrophoretic mobility-shift assay analysis confirmed specific binding of STAT-1 and STAT-3 to this region.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10359822

RAPF D9C2bDz3q0uuQxMKS6IVmp3RhpoUqarXTUc5HVWw
has assertion: p(MGI:Lif) -> tscript(p(MGI:Stat3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.318+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Lif) -> tscript(p(MGI:Stat3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10359822

5
value: Pituitary corticotroph SOCS-3 is inhibiting LIF-activated Janus kinase-signal transducers and activators of transcription (STAT) signaling in a negative autoregulatory loop. We now demonstrate in corticotroph AtT-20 cells that LIF-stimulated endogenous SOCS-3 mRNA expression is blocked in stable transfectants of SOCS-3 wild type or in dominant negative STAT-3 mutants, respectively.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10359822

RANBMRvOvH3sExRCbwv8yEK5nc4HX0ti-A0KxXSDpeRzE
has assertion: bp(GO:"response to stress") -> r(RGD:Glul)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.330+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to stress") -> r(RGD:Glul)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10362628

3
value: Acute stress or direct glucocorticoid administration raises muscle GS mRNA levels dramatically without a parallel increase in GS protein levels.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10362628

RAPSHvKlAqM1esbhsegyPzpPA-MaJLCJFXGNfX19kmoaU
has assertion: a(CHEBI:lipopolysaccharide) -> r(HGNC:TNF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.334+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(HGNC:TNF)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10362677

3
value: Moreover, both isoproterenol and dibutyryl cAMP inhibited LPS-induced TNF-alpha mRNA expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10362677

RAAB86rmDfUIxOFWLZIHilcMaJbFRTKdpjedS0gLMU268
has assertion: p(HGNC:EGF) -> kin(p(PFH:"AKT Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.350+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> kin(p(PFH:"AKT Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10364198

5
value: EGF stimulation of Akt kinase activity blocked Fas-induced apoptosis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10364198

RABNOJTjhXcl6iphdPTlGPp4k6OS6rAePpQ5R9wUpPz1c
has assertion: a(SCHEM:"serum insulin") -> r(RGD:Egr1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.352+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> r(RGD:Egr1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10364249

3
value: Insulin induces Egr-1 mRNA
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10364249

RAGsDEKot-xxi722U R23TbXib9kjHCYFPKytwc18FSV8
has assertion: kin(p(PFH:"PRKC Family")) -> gtp(p(HGNC:RAC2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.362+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> gtp(p(HGNC:RAC2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10364257

6
value: stimulation of human neutrophils with the Gi-coupled receptor agonists N-formyl-methionyl-leucyl-phenylalanine (fMLP) and leukotriene B4 (LTB4) leads to a rapid and transient increase in the GTP-bound state of Rac2, whereas phorbol myristate acetate (PMA) causes a slow but more sustained activation of Rac2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10364257

RAOn9af3rVKE4kF6NKu4jt7HWWWNdkMi RztKUT2msjSc
has assertion: gtp(p(PFH:"RAS Family")) -| r(HGNC:AFP)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.367+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(PFH:"RAS Family")) -| r(HGNC:AFP)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10365819

5
value: Levels of AFP mRNA but not albumin mRNA were elevated by simvastatin in a dose-dependent manner (1-10 micromol/l).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10365819

RAPcH7q95H3cnYHSEMx7rXuUKZ0ReTjFbmsHnKIetZUGg
has assertion: p(HGNC:IL13) -| p(HGNC:MMP13)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.369+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL13) -| p(HGNC:MMP13)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10366107

4
value: IL-13 inhibited collagenase 3 production, IL-4 had little effect, and IL-10 had none.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10366107

RAKGSTdCLojGmG-7nX zKtUiIrO2lrXFwE7DEsh24tRkA
has assertion: a(SCHEM:"cyclic AMP") -> tloc(p(HGNC:BTG1),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.373+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -> tloc(p(HGNC:BTG1),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10366433

4
value: T3 or 8-Br-cAMP increases BTG1 nuclear accumulation in confluent myoblast cultures. In this study, we report that BTG1 is essentially expressed at cell confluence and in differentiated myotubes
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10366433

RAGee Zoq8VvrMwI1Ks ZuWfPbkwTXiOl1gHY08c7cVDQ
has assertion: p(HGNC:BTG1) -> bp(GO:"myoblast differentiation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.374+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:BTG1) -> bp(GO:"myoblast differentiation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10366433

3
value: the stimulation of BTG1 nuclear accumulation by T3 or 8-Br-cAMP probably results from an increased nuclear import or retention in the nucleus. Lastly, BTG1 overexpression in quail myoblasts mimicked the T3 or 8-Br-cAMP myogenic influence: (i) inhibition of myoblast proliferation due to an increased rate of myoblast withdrawal from the cell cycle; and (ii) stimulation of terminal differentiation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10366433

RAJvUH06bMjW4y2ldASHN1hotK75Hb-eu1EXJ9Y2RAsCA
has assertion: kin(p(PFH:"PRKC Family")) => p(HGNC:GRIA4,pmod(P,T,850))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.380+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) => p(HGNC:GRIA4,pmod(P,T,850))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10366608

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10366608

RALGEDVe9kIJUceNbdw-EM9BqDiB-lTwmWLamfZKFAuZM
has assertion: cat(p(HGNC:IRS1)) -> kin(p(PFH:"MAPK Erk1/3 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.388+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:IRS1)) -> kin(p(PFH:"MAPK Erk1/3 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10371394

6
value: Cells transfected with IRS-1 had increased levels of DNA synthesis, PCNA, GAPDH, and activated MAPK
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10371394

RAIaa8gHSKvM5FmpTWpmZnY ZFB9ke3kft7ORynl3jB3Q
has assertion: a(SCHEM:"serum insulin") -> cat(p(HGNC:PDE3B))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.397+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> cat(p(HGNC:PDE3B))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10373426

4
value: Phosphodiesterase 3 (PDE3) activity was stimulated by ASP and insulin, whereas PDE4 activity was slightly increased by ASP only.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10373426

RABR v1SbvG3i5EX80IwgJ2So8OELglWcvPDFhcBv3C2U
has assertion: a(SCHEM:"serum insulin") -| path(SDIS:"fatty acid import")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.401+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -| path(SDIS:"fatty acid import")
label: cat(p(HGNC:PDE3B)) -> (a(SCHEM:"serum insulin") -| path(SDIS:"fatty acid import"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10373426

5
value: Selective PDE3 inhibition reversed the effects of both ASP and insulin on fractional FFA re-esterification and lipolysis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10373426

RAH2HAXnHMmRKigO1UctJjQdJbT8z13jq7tWg0x-yew2I
has assertion: a(SCHEM:"serum insulin") -> path(SDIS:"fatty acid esterification")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.407+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum insulin") -> path(SDIS:"fatty acid esterification")
label: cat(p(HGNC:PDE3A)) -> (a(SCHEM:"serum insulin") -> path(SDIS:"fatty acid esterification"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10373426

5
value: Selective PDE3 inhibition reversed the effects of both ASP and insulin on fractional FFA re-esterification and lipolysis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10373426

RAC9QAkRZDBqw5WH6xspeswCs8QHOMcIWGFchU-Hj-TKw
has assertion: bp(GO:"cell adhesion") -> p(HGNC:PTK2,pmod(P,Y,576))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.414+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"cell adhesion") -> p(HGNC:PTK2,pmod(P,Y,576))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10373530

3
value: Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at multiple sites, including tyrosines 397, 576, and 577. Tyr-397 is an autophosphorylation site that promotes interaction with c-Src or Fyn.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10373530

RAPXCqIhlAHj8zuGcSnCsY6CPKpzxUq4Ep2iuovvqS8RA
has assertion: cat(p(HGNC:SH2B2)) -| tscript(p(PFH:"STAT5 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.421+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:SH2B2)) -| tscript(p(PFH:"STAT5 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10374881

6
value: Co-expression of APS and c-Cbl, but not expression of either alone inhibited EPO-dependent STAT5 activation in 293 cells. This required the C-terminal phosphorylation site, as well as PH and SH2 domains of APS. Therefore, one of the major functions of APS is in recruitment of c-Cbl into the receptor/JAK complex, thereby inhibiting JAK signaling activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10374881

RAJUNSJSDlOF Sn0g0x3VfiUjq6jKUpqeR9PAVxJZrh1U
has assertion: kin(p(HGNC:JAK2)) -> p(HGNC:SH2B2,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.422+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:JAK2)) -> p(HGNC:SH2B2,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10374881

5
value: Here, we report that APS was tyrosine phosphorylated by Janus kinase-2 (JAK2) at its C-terminal tyrosine residue and interacted with c-Cbl.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10374881

RAFaGaKxOIJhAgoRFm58-LN1Pd08YPR4BuxuU IQf901M
has assertion: p(HGNC:NRG1) -> kin(p(HGNC:ERBB2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.429+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NRG1) -> kin(p(HGNC:ERBB2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10376522

5
value: Exogenously added heregulin induced Erk activation, which was blocked by herceptin, which is an antibody against HER-2/neu.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10376522

RAPfu-RfUqr-OfOwImQ4abiqW4iJzaC2ix6pbOuhIv7vQ
has assertion: p(HGNC:SELE) -> bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.444+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:SELE) -> bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10377075

3
value: These EC adhesion molecules include vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin, and P-selectin.6,7
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10377075

RAIEjePlNWx9aagVNfi-nxJ8ifciEhelm3XbYjGMlpZts
has assertion: p(HGNC:VCAM1) -> bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.446+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:VCAM1) -> bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10377075

3
value: These EC adhesion molecules include vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin, and P-selectin.6,7
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10377075

RAOlHejKHh5vhn2eOxxDy0FCwUyGclf3p-0hr cdywGMU
has assertion: a(CHEBI:fenofibrate) -| (tscript(complex(NCH:"Nfkb Complex")) => r(HGNC:VCAM1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.447+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:fenofibrate) -| (tscript(complex(NCH:"Nfkb Complex")) => r(HGNC:VCAM1))
label: tscript(complex(NCH:"Nfkb Complex")) => r(HGNC:VCAM1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10377075

5
value: Transient transfection of deletional VCAM-1 promoter constructs and electrophoretic mobility shift assays indicate that fenofibrate inhibits VCAM-1 transcription in part by inhibiting NF-kappaB.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10377075

RAGOSNk86WmsFwOT8 p1lR-3cQrBAAnXrjN2 AH0UO3tY
has assertion: a(CHEBI:testosterone) -> r(MGI:Aox1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.455+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:testosterone) -> r(MGI:Aox1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10377246

3
value: Treatment of female mice with testosterone increases the amounts of AO mRNA and of the relative translation product to levels similar to those in male animals.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10377246

RAAkVOzQQSohumR NYTxOvrc61HP5czjTQDG1-4rTP0I0
has assertion: complex(p(HGNC:KIT),p(HGNC:KIT)) => kin(p(HGNC:KIT))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.457+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:KIT),p(HGNC:KIT)) => kin(p(HGNC:KIT))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10377264

7
value: % In this paper we demonstrate the presence of two novel in vivo autophosphorylation sites in the c-Kit/stem cell factor receptor (c-Kit/SCFR): Tyr-703 in the kinase insert and Tyr-936 in the C-terminal tail.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10377264

RAOOrqG9MHTV-Tx51HFdTeT9auiLCDlyjyQauual4ZN Y
has assertion: kin(p(HGNC:KIT)) => p(HGNC:KIT,pmod(P,Y,703))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.459+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:KIT)) => p(HGNC:KIT,pmod(P,Y,703))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10377264

5
value: In this paper we demonstrate the presence of two novel in vivo autophosphorylation sites in the c-Kit/stem cell factor receptor (c-Kit/SCFR): Tyr-703 in the kinase insert and Tyr-936 in the C-terminal tail. We furthermore demonstrate that the adapter protein Grb2 is a specific binding partner for both phosphorylated Tyr-703 and phosphorylated Tyr-936,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10377264

RABgY4wCmEJ9TQk1yfGX2-wPxAR5uhRxdxu-VcR8nxV30
has assertion: kin(p(HGNC:KIT)) => p(HGNC:KIT,pmod(P,Y,936))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.461+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:KIT)) => p(HGNC:KIT,pmod(P,Y,936))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10377264

5
value: In this paper we demonstrate the presence of two novel in vivo autophosphorylation sites in the c-Kit/stem cell factor receptor (c-Kit/SCFR): Tyr-703 in the kinase insert and Tyr-936 in the C-terminal tail. We furthermore demonstrate that the adapter protein Grb2 is a specific binding partner for both phosphorylated Tyr-703 and phosphorylated Tyr-936,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10377264

RAOc PkvavWthsXz72Re4GikbKEaZC fDw1EIt8Fm1qs4
has assertion: kin(p(HGNC:KIT)) => p(HGNC:KIT,pmod(P,Y,936))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.464+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:KIT)) => p(HGNC:KIT,pmod(P,Y,936))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10377264

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10377264

RADL6CaciZcXhM2qe6WbiJtHaOq9HNRLMVnpBOFkHVi1w
has assertion: a(CHEBI:caffeine) -| cat(p(PFM:"Pde Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.481+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:caffeine) -| cat(p(PFM:"Pde Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10379625

4
value: caffeine, a non-specific phosphodiesterase (PDE) inhibitor
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10379625

RAPa2--oQ-LcJnKXPOvV1OuCwfCjTO9-EpqfQoToG6YUQ
has assertion: tscript(complex(NCH:"AP-1 Complex")) -> r(HGNC:MSR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.487+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"AP-1 Complex")) -> r(HGNC:MSR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10381284

4
value: We could demonstrate that alpha-tocopherol down-regulates scavenger receptor activity in macrophages in a dose-dependent manner. Scavenger receptor activity was reduced by 13, 16, 18 and 24% in the presence of 1, 5, 10 and 50 microM alpha-tocopherol, respectively. This effect was associated with a reduced SR-A mRNA expression and activity of AP-1 binding transcription factors in the presence of alpha-tocopherol
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10381284

RAKP9k VcN-x9bVWDugfL271M tQPgF1D8YArCiRzyH 4
has assertion: p(HGNC:ERBB2) -> p(HGNC:PXN)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.498+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ERBB2) -> p(HGNC:PXN)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10383144

4
value: HER2-overexpressing cell lines and cells with coexpression of HER2 and HER3 receptors exhibited elevated levels of paxillin, as compared to low HER2 expressing cell lines or HER2 expression with undetectable HER3 level, paxillin expression dose not correlate well with HER1 expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10383144

RAA-zqbyUB5jtySX97JSosQ0vQVHkgwc-euXJ-rURhPNk
has assertion: p(HGNC:ERBB3) -> p(HGNC:PXN)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.499+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ERBB3) -> p(HGNC:PXN)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10383144

4
value: HER2-overexpressing cell lines and cells with coexpression of HER2 and HER3 receptors exhibited elevated levels of paxillin, as compared to low HER2 expressing cell lines or HER2 expression with undetectable HER3 level, paxillin expression dose not correlate well with HER1 expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10383144

RAPdC6-c YpG1TGnmvoqgglDERbtwQF1JFfFyYrmdkTL4
has assertion: p(HGNC:NRG1) -> p(HGNC:PXN)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.500+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NRG1) -> p(HGNC:PXN)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10383144

4
value: Here, we report that HRG stimulation of noninvasive breast cancer MCF-7 cells resulted in the up-regulation of paxillin mRNA and protein.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10383144

RACb4Btes5b3COSgEwjKULk7UgY45c8SZCVLGIxoJYFls
has assertion: a(CHEBI:"trichostatin A") -> r(HGNC:CPA3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.502+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"trichostatin A") -> r(HGNC:CPA3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10383164

3
value: Trichostatin A, a potent and specific inhibitor of histone deacetylase, also induced CPA3 mRNA expression, suggesting that CPA3 gene induction is mediated by histone hyperacetylation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10383164

RAKcRAo1RVG97eEaevEkh zQMh0dSrnHxOwxkiv-9jxe4
has assertion: p(MGI:Cdkn1a) -> complex(p(MGI:Ccnd1),p(MGI:Cdk4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.517+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Cdkn1a) -> complex(p(MGI:Ccnd1),p(MGI:Cdk4))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10385618

6
value: In a later complementary study, Cheng et al. (1999) observed that assembly of cyclin D1/D2-CDK4 complexes was impaired in primary mouse embryo fibroblast (MEF) strains taken from animals lacking the p21 gene, the p27 gene, or both.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10385618

RAAfdt9ctApEXQLV YRJwixUmJx3eGgvIFRVTn84Moq3s
has assertion: p(MGI:Cdkn1b) -> complex(p(MGI:Ccnd2),p(MGI:Cdk4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.520+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Cdkn1b) -> complex(p(MGI:Ccnd2),p(MGI:Cdk4))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10385618

6
value: In a later complementary study, Cheng et al. (1999) observed that assembly of cyclin D1/D2-CDK4 complexes was impaired in primary mouse embryo fibroblast (MEF) strains taken from animals lacking the p21 gene, the p27 gene, or both.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10385618

RAP4aln-dqE-0bvSzVK L1rVP8vP8Dk8tgCp093c0iclQ
has assertion: complex(p(HGNC:CCND1),p(HGNC:CDK4)) =| (p(HGNC:CDKN1B) =| kin(p(HGNC:CDK2)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.524+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:CCND1),p(HGNC:CDK4)) =| (p(HGNC:CDKN1B) =| kin(p(HGNC:CDK2)))
label: p(HGNC:CDKN1B) =| kin(p(HGNC:CDK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10385618

9
value: Titration of unbound p27Kip1 and p21Cip1 molecules into higher order complexes with assembling cyclin D-dependent kinases relieves cyclin E-CDK2 from Cip/Kip constraint, thereby facilitating cyclin E-CDK2 activation later in G1 phase.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10385618

RAIIOlErnNokauWD2PCtGaHPcgMBVqi7w48AvXm-7IJwE
has assertion: p(HGNC:NGF) -> r(HGNC:CTSB)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.527+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:CTSB)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10390549

4
value: Basic FGF and NGF treatment of macrophages and microglia significantly increased the levels of cathepsin S, B, and L mRNAs
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10390549

RAKe2QiG4UfI2zezbe9aioIQ5ClWPBKB9Tgk0A1Dn4I-Q
has assertion: p(HGNC:NGF) -> r(HGNC:CTSS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.529+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:CTSS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10390549

4
value: Basic FGF and NGF treatment of macrophages and microglia significantly increased the levels of cathepsin S, B, and L mRNAs
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10390549

RAIJf VIE6UeVULkFUK63OM-9bilVrKw4HkHo16styg7Q
has assertion: kin(p(HGNC:ABL1)) => p(HGNC:TP73,pmod(P,Y,99))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.530+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:ABL1)) => p(HGNC:TP73,pmod(P,Y,99))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10391251

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10391251

RAIjHY TKYUmMKWBi3h0WuCAybwqstWBzVaSKzSJAzRjw
has assertion: p(HGNC:MAP2K6) -> kin(p(PFH:"MAPK p38 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.533+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MAP2K6) -> kin(p(PFH:"MAPK p38 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10391894

5
value: expression of MKK6b(E), a constitutive activator of p38(MAPK), significantly reduced LDL receptor promoter activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10391894

RAHLq5umdfDtRlhbfoVe0FJSJEOgfnGkrAArtVdktFWLA
has assertion: p(MGI:Pawr) -| tscript(complex(NCM:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.540+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Pawr) -| tscript(complex(NCM:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10391896

4
value: NF-kappaB activation by tumor necrosis factor alpha (TNFalpha) provides a survival signal that impairs the TNFalpha-induced apoptotic response. We show here that expression of Par-4 inhibits the TNFalpha-induced nuclear translocation of p65 as well as the kappaB-dependent promoter activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10391896

RAB7oqOQTAbcJV1lp3HAdpJQMDXrgqqz47O2ZsnlHd7Po
has assertion: p(MGI:Tnf) -> tscript(complex(NCM:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.542+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Tnf) -> tscript(complex(NCM:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10391896

4
value: NF-kappaB activation by tumor necrosis factor alpha (TNFalpha) provides a survival signal that impairs the TNFalpha-induced apoptotic response. We show here that expression of Par-4 inhibits the TNFalpha-induced nuclear translocation of p65 as well as the kappaB-dependent promoter activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10391896

RAB d0wBLrABizoajGC1Z4W3oIA lo3V8JqYbZSmn3uK0
has assertion: p(MGI:Tnf) -> tloc(p(MGI:Rela),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.545+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Tnf) -> tloc(p(MGI:Rela),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10391896

5
value: NF-kappaB activation by tumor necrosis factor alpha (TNFalpha) provides a survival signal that impairs the TNFalpha-induced apoptotic response. We show here that expression of Par-4 inhibits the TNFalpha-induced nuclear translocation of p65 as well as the kappaB-dependent promoter activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10391896

RACGm9Sqrp9nuDVdRCrY8ZAIGgg729qey21b0A6K-N-mQ
has assertion: p(MGI:Pawr) -| (p(MGI:Tnf) -> tscript(complex(NCM:"Nfkb Complex")))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.546+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Pawr) -| (p(MGI:Tnf) -> tscript(complex(NCM:"Nfkb Complex")))
label: p(MGI:Tnf) -> tscript(complex(NCM:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10391896

6
value: Of potential functional relevance, the expression of Par-4 allows TNFalpha to induce apoptosis in NIH-3T3 cells. In addition, the down-regulation of Par-4 levels by oncogenic Ras sensitizes cells to TNFalpha-induced NF-kappaB activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10391896

RAKVCOrH8LuLvyVxAf aUl1l0XNG7O7wJD0cuG1yla 1E
has assertion: cat(p(RGD:F2)) -> surf(p(RGD:Nsfl1c))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.550+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:F2)) -> surf(p(RGD:Nsfl1c))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10391925

6
value: Furthermore, thrombin increased expression of p47(phox) and Rac2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10391925

RAGLWR0TsjbFV7UhPENoGFFYG- 2inlbhkvHgdrzYxw4g
has assertion: gtp(p(RGD:Rac2)) -> cat(complex(NCR:"NADPH Oxidase Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.551+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(RGD:Rac2)) -> cat(complex(NCR:"NADPH Oxidase Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10391925

5
value: we examined whether the cytosolic components of the phagocytic NAD(P)H oxidase were present in VSMC. p47(phox) and Rac2 were present in VSMC
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10391925

RAFAkmz5nvurolWXI2MURUxpvyPzTT2qg0-cNXIiDggrU
has assertion: a(CHEBI:fulvestrant) -> p(HGNC:NDRG1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.568+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:fulvestrant) -> p(HGNC:NDRG1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10395947

3
value: It was increased in mammary carcinoma MCF-7 cells treated by retinoids and by the anti-estrogen ICI 182,780 but not by 4-hydroxytamoxifen.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10395947

RALhAFdd4dxQX05XSvl64PPJdCQWrED4TkEdGrnvPEVHQ
has assertion: kin(p(PFH:"PRKC Family")) -> r(HGNC:NDRG1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.578+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> r(HGNC:NDRG1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10395947

5
value: These antibodies revealed a protein with the expected 43 kDa molecular mass, up-regulated by phorbol ester, retinoids and 1,25-(OH)2 vitamin D3 in U937 cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10395947

RAK2lbzas9LnkT2APP7-g4rXkXrMBIfv99ZaurjOsM0as
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:PTPRO)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.590+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:PTPRO)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10397721

3
value: PTP-RO mRNA and protein expression are upregulated upon phorbol 12-myristate 13-acetate (PMA) treatment of the megakaryocytic cell lines CMS, CMK, and Dami.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10397721

RACozT04NLh1njPCUgoKzcS25UAnSAkIQ5WCU2HrNwuaY
has assertion: cat(p(HGNC:GSN)) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.598+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:GSN)) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10400609

4
value: Caspase-3 also cleaves and activates gelsolin, a protein that regulates actin dynamics. Interestingly, activated gelsolin promotes both cytoplasmic and nuclear apoptosis, including DNA fragmentation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10400609

RAGEDIduIUFkeT4tZHzeyK8zxj6fVO1MyItLlti96E3fo
has assertion: a(SCHEM:Calcium) -> r(HGNC:TGM1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.608+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> r(HGNC:TGM1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10400667

3
value: Ca2+ increased the levels of involucrin and transgultaminase mRNA in human keratinocytes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10400667

RALod2NxBlx-ucEyx hwc1WaZSSRoW c7xoA5yzmQV 8Q
has assertion: kin(p(HGNC:PTK2)) -> p(HGNC:AKT1,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.610+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PTK2)) -> p(HGNC:AKT1,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10400703

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10400703

RAB9bUXlykiiyjZvD79BkZE-kqP27irTihNVNwa6H-Tx4
has assertion: a(CHEBI:"okadaic acid") -| tloc(p(MGI:Ptpn14),GOCCACC:"GO:0005856",GOCCACC:"GO:0005737")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.615+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"okadaic acid") -| tloc(p(MGI:Ptpn14),GOCCACC:"GO:0005856",GOCCACC:"GO:0005737")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10400706

4
value: On the contrary, when the dephosphorylation of PTP36 was inhibited by okadaic acid, no translocation of PTP36 was induced by the cell detachment
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10400706

RAPXWZw2gVRLmGsFIV9Z6RHamTnZRtfSyah7X61c5nTPE
has assertion: a(CHEBI:staurosporine) -> tloc(p(MGI:Ptpn14),GOCCACC:"GO:0005737",GOCCACC:"GO:0005856")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.620+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:staurosporine) -> tloc(p(MGI:Ptpn14),GOCCACC:"GO:0005737",GOCCACC:"GO:0005856")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10400706

4
value: Staurosporine and ML-9, which inhibited the phosphorylation of PTP36 in vivo, induced the translocation of PTP36 too.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10400706

RAEjq9cIQLLUCpWULVHOQs6Nrv9eJyR6JDvvS8LvxwpL0
has assertion: phos(p(MGI:Ptpn14)) -| bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.625+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(MGI:Ptpn14)) -| bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10400706

4
value: Summary: The dephosphorylated form of PTPN14 translocates to the cell membrane associated cytoskeleton where it dephosphorylates proteins of the adherens junction, causing cellular detachment. Phosphorylation of PTPN14 induces it's sequestration in the cytoplasm.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10400706

RAJkFvrRb2FhoC1wmFlivxloyWHZZb8qSqtPxtjkjve24
has assertion: a(SCHEM:"Sodium Salicylate") -| kin(p(PFH:"IkappaB Kinase Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.633+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Sodium Salicylate") -| kin(p(PFH:"IkappaB Kinase Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10402163

4
value: Aspirin and sodium salicylate inhibit activation of NF-KB by blocking IkappaB kinase, a key enzyme in NF-kappaB activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10402163

RAECWPS1u12iRIX5OT5g6Bnw3L9ljetg1BnUo7E2T5E14
has assertion: a(CHEBI:glucocorticoid) -> r(HGNC:NFKBIA)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.636+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glucocorticoid) -> r(HGNC:NFKBIA)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10402163

3
value: Glucocorticoids suppress expression of inflammatory genes by binding glucocorticoid receptor with NF-kappaB, and increasing expression of inhibitory protein of NF-kappaB, IkappaBalpha
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10402163

RAF2gI-CCwZqCZ7BQBOXCzbEEJEL1w5o022YdJ1konSMs
has assertion: kin(p(HGNC:EGFR)) -> a(SCHEM:Calcium)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.648+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:EGFR)) -> a(SCHEM:Calcium)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10403803

4
value: A431 cells expressing annexin VI are defective in their ability to sustain elevated levels of cytosolic Ca(2+) following stimulation with EGF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10403803

RAIa2Z6XZ-ilOs2GHdj6fyJqxUW0TSrQoM5iaQCoIduzk
has assertion: kin(p(MGI:Prkcz)) -> p(MGI:Twf2,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.653+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Prkcz)) -> p(MGI:Twf2,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10406962

5
value: A6rp was found to be expressed at the mRNA and the protein levels in all cells and tissues investigated. GST-A6rp was phosphorylated by PKCzeta but not significantly by other PKC isoenzymes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10406962

RAFyhuXsdL9dnvXzS0zS1tlqZ6dsEvH3IneqKUinrNSiI
has assertion: p(HGNC:SNCA) -| kin(p(HGNC:PRKCA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.655+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:SNCA) -| kin(p(HGNC:PRKCA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10407019

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10407019

RAO 8ybWpIcnztLPlyHLHFoDKFOrrBUWhjr97DMiTomg
has assertion: p(RGD:Slc2a1) -> p(RGD:Akr1b1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.657+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Slc2a1) -> p(RGD:Akr1b1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10409302

4
value: AR protein levels, AR activity, sorbitol production, and PKCalpha protein content were also greater in the MCGT1 cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10409302

RAPkk9oUNvf1wdaGG7uCUh2BjOUyrJGzR5S4L PQ1kTJg
has assertion: kin(p(PFR:"Akt Family")) => p(RGD:Bad,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.664+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFR:"Akt Family")) => p(RGD:Bad,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10409722

5
value: Akt directly links growth factor signaling to the central pathways controlling programmed cell death by phosphorylating the Bcl-2 family member BAD
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10409722

RAG uXzCK0KUKK014qemZj vNHpugCo8-tikTF4vs-H1U
has assertion: cat(p(RGD:Bcl2)) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.668+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Bcl2)) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10409722

4
value: Bcl-2 or Bcl-xL to function as inhibitors of apoptosis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10409722

RAIjlXzSChA0hA3TwE2HqYhbQ1ZYiUshywxDy2RF-FrTc
has assertion: a(SCHEM:"LY 294002") -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.681+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"LY 294002") -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10409722

2
value: Similar results were obtained in both Rat-1 and Rat-1/B-Raf cells when apoptosis was induced by treatment with the PI 3-kinase inhibitor LY294002 in the presence of serum
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10409722

RACl77opC9 3dmX9goYRoz1A6Rj-D0b5s8RcjpRcje8L0
has assertion: p(HGNC:CSF3) -> complex(p(HGNC:CSF3R),p(HGNC:IL6ST))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.687+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CSF3) -> complex(p(HGNC:CSF3R),p(HGNC:IL6ST))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10409724

6
value: HepG2 cells were transfected with expression vector for G-gp130 (WT) and Myc SHP-2CS or SHP-2-Myc and then were treated for 15 minutes with G-CSF, showed that gp130-recruited SHP-2 serves as a major mediator to the ERK pathway and that this function requires the carboxy-terminal half but not the phosphatase activity of the SHP-2 protein.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10409724

RAK fKlrmctbojRNXKfquJx4M1ogVRLXWVkCY7d0yajdI
has assertion: kin(p(HGNC:MAP3K5)) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.700+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAP3K5)) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10411906

4
value: Here we report that ASK1 proapoptotic activity is antagonized by association with 14-3-3 proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10411906

RAGwViY1lbm9-aQ0V7D6K3THmcOFtMn3f2j4Y3H60A9WM
has assertion: p(HGNC:NGF) -> r(HGNC:CX3CL1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.722+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:CX3CL1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10415068

4
value: Only NGF slightly increased fractalkine message expression in hypothalamic neurons.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10415068

RANMmrpsYI9QUJ6jtHpNs0dvXkf4AVjbKyVO0f3wC6VmM
has assertion: a(SCHEM:Estrogens) -| r(RGD:Il6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.726+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Estrogens) -| r(RGD:Il6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10415730

3
value: In contrast, estrogen treatment decreased the expression of interleukin-6 (IL-6) (39%), carbonic anhydrase II (CA II) (36%), and osteopontin (OP) (37%)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10415730

RAPzx4hMf8bXhIshi071RS6zYgdXscLvet8FrKaIoMOQY
has assertion: a(SCHEM:"CP-24879") -| a(CHEBI:"arachidonic acid")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.729+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"CP-24879") -| a(CHEBI:"arachidonic acid")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10419129

2
value: CP-24879 inhibited combined delta 6 and delta 5 desaturase activities and caused partial depletion of AA in liver.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10419129

RAGPacfROthuDoQpPQvR-uH1IFiseXLkxeWSy20kEPnow
has assertion: p(MGI:Fads2) -> bp(GO:"inflammatory response")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.732+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Fads2) -> bp(GO:"inflammatory response")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10419129

3
value: Inadequate delta 6 desaturase activity has been correlated with chronic inflammatory disease...inhibition of delta 6 desaturase activity by SC-26196 caused a dose dependent increase in total fatty acid content and accompanying lipidosis in mouse liver.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10419129

RAL-qtJOt9mJTLUTNf15wwYi03fZ3mCNUaZsc0BNFNDFw
has assertion: tscript(complex(NCR:"Nfkb Complex")) -> r(RGD:Tnc)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.738+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCR:"Nfkb Complex")) -> r(RGD:Tnc)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10419501

4
value: mechanical strain increases tenascin-C gene transcription by activating nuclear factor-kappaB through reactive oxygen species.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10419501

RAP15wqxHLm8bE9llHt1Ew2E5SBoVvbMtoOye-yik4k U
has assertion: a(SCHEM:"Concanavalin A") -> cat(p(HGNC:MMP14))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.741+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Concanavalin A") -> cat(p(HGNC:MMP14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10421655

4
value: Specific antibodies against the subunits of alpha2beta1 integrins, the major collagen I receptor, induced partial inhibition of MMP2 activation. Treatment of cells with concanavalin A resulted in a marked activation of MMP2 that correlated with the proteolytic processing of MT1-MMP, the MMP2 activator, from a Mr=60 kd toward a Mr=43 kd polypeptide.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10421655

RAEyUgxpELegUPz0sNtLmzWWU1HzOLITipFWu-xOAfQIc
has assertion: complex(p(MGI:Il4),p(MGI:Il4ra)) -> p(MGI:Jak3,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.746+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(MGI:Il4),p(MGI:Il4ra)) -> p(MGI:Jak3,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10421786

6
value: However, disruption of a membrane-proximal proline-rich sequence motif ('box1') in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10421786

RACchQ1Q0 Wg2f0JAJOPD RXMvPeYLSJrny5klf1CodTY
has assertion: kin(p(MGI:Ikbke)) -> p(MGI:Nfkbia,pmod(P,S,32))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.753+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Ikbke)) -> p(MGI:Nfkbia,pmod(P,S,32))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10421793

5
value: Overexpression of wild-type IKK-i phosphorylated serine residues Ser32 and Ser36 of IkappaB-alpha (preferentially Ser36), and significantly stimulated NF-kappaB activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10421793

RAGnMgXKlaq9CSQ4Tand-VOIsV8ObOdqP8pfrQIJX93s0
has assertion: a(CHEBI:thapsigargin) -> p(HGNC:TNF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.754+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:thapsigargin) -> p(HGNC:TNF)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10422778

3
value: The cyclooxygenase inhibitor indomethacin inhibited prostaglandin E2 production, and further enhanced thapsigargin-induced tumor necrosis factor-alpha production in parallel with further increase in cell-associated PAF production.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10422778

RAIZSwYh2W5tvOdYbHzpvU 41JKCFBHPdSew4OfAnno0Q
has assertion: bp(GO:"response to oxidative stress") -> p(RGD:Serpinf1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.757+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to oxidative stress") -> p(RGD:Serpinf1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10423332

3
value: Levels above normal were seen for alpha(2)-antiplasmin and factor X at 48 h, normalizing at 72 h
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10423332

RAP3lFCtA0V8bVtlZUGxo2UOBITAg0iC6XVqbuhG45SWw
has assertion: bp(GO:"response to oxidative stress") -> cat(p(RGD:Plg))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.759+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to oxidative stress") -> cat(p(RGD:Plg))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10423332

4
value: The sequential changes over time indicate that kallikrein - kinin activation, and plasminogen activation are probably early events in cerulein-induced AP in rats
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10423332

RAAcDg2S0P8YqBGgK81tbr5unFGvBysqa 7Ci47eT8WiI
has assertion: complex(p(HGNC:HIF1A),p(HGNC:ARNT)) => tscript(p(HGNC:ARNT))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.765+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:HIF1A),p(HGNC:ARNT)) => tscript(p(HGNC:ARNT))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10425220

7
value: Hypoxia inducible factor-1 (HIF-1) is a transcription factor composed of two subunits, HIF-1alpha and ARNT, which is activated under hypoxia.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10425220

RALfP3xc9uIWQQHrCxmV0ZTkIgRjllbTbpI-szd14vSgg
has assertion: tscript(p(HGNC:ARNT)) => complex(p(HGNC:HIF1A),p(HGNC:ARNT))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.767+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:ARNT)) => complex(p(HGNC:HIF1A),p(HGNC:ARNT))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10425220

7
value: Hypoxia inducible factor-1 (HIF-1) is a transcription factor composed of two subunits, HIF-1alpha and ARNT, which is activated under hypoxia.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10425220

RAEUBeqzvE01hDEFhKrybgL0xQhE8qKhARQA1Ww3P1MAg
has assertion: p(HGNC:PRL) -> tloc(p(HGNC:STAT5B),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.800+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PRL) -> tloc(p(HGNC:STAT5B),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10428824

5
value: Following prolactin activation, both STAT5A and STAT5B were rapidly translocated into the nucleus and displayed a detergent-resistant, punctate nuclear staining pattern.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10428824

RALvxLlUDYs6pkmBWjbbJwhTiuES67pG5SyEYXIBLrXv4
has assertion: p(HGNC:PRL) -> p(HGNC:STAT5B,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.802+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PRL) -> p(HGNC:STAT5B,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10428824

4
value: Similar to prolactin induction, src activation resulted in tyrosine phosphorylation and DNA binding of both STAT5A and STAT5B. However, nuclear translocation of only STAT5B but not STAT5A was observed.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10428824

RALGvNd9-yqs0zsYubYM3AXuY-EdNYP6YTGlsVhGB VIY
has assertion: kin(p(HGNC:SRC)) -> tloc(p(HGNC:STAT5B),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.803+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:SRC)) -> tloc(p(HGNC:STAT5B),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10428824

6
value: Similar to prolactin induction, src activation resulted in tyrosine phosphorylation and DNA binding of both STAT5A and STAT5B. However, nuclear translocation of only STAT5B but not STAT5A was observed.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10428824

RALrnSq9dqX2pLXxE0-t8oV-LcqvwxsesKyjYQcv0yFx8
has assertion: a(CHEBI:"prostaglandin H2") -> path(MESHD:Ischemia)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.808+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"prostaglandin H2") -> path(MESHD:Ischemia)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10429677

2
value: We conclude that hypoxia-reoxygenation elicits the formation of superoxide, which causes loss of the vasodilatory action of NO and at the same time yields peroxynitrite. Subsequently, peroxynitrite nitrates and inactivates PGI2 synthase, leaving unmetabolized prostaglandin H2, which causes vasospasm, platelet aggregation, and thrombus formation via the TxA2/prostaglandin H2 receptor
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10429677

RAOsSS4cOpHIB0Nu ly1Bzol OR-E05TjPPbqV 36t364
has assertion: bp(GO:"smooth muscle contraction") -> bp(GO:vasoconstriction)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.811+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"smooth muscle contraction") -> bp(GO:vasoconstriction)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10429677

2
value: We conclude that hypoxia-reoxygenation elicits the formation of superoxide, which causes loss of the vasodilatory action of NO and at the same time yields peroxynitrite. Subsequently, peroxynitrite nitrates and inactivates PGI2 synthase, leaving unmetabolized prostaglandin H2, which causes vasospasm, platelet aggregation, and thrombus formation via the TxA2/prostaglandin H2 receptor
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10429677

RADxKt8JqpCT7AVhnK54vsMsbkfTenNcOgY25-7FqFKkA
has assertion: a(SCHEM:Diacylglycerol) -> kin(p(RGD:Prkce))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.816+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Diacylglycerol) -> kin(p(RGD:Prkce))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10431815

4
value: Finally, we show that calsequestrin is an epsilonprotein kinase C substrate in vitro and protein kinase C phosphorylation of calsequestrin leads to a decreased binding of epsilonprotein kinase C to calsequestrin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10431815

RANHNG4P5ALlsp ZYmVarInRs3gfF4krDxGmuAZM2mUFA
has assertion: kin(p(RGD:Prkce)) -> p(RGD:Casq2,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.817+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(RGD:Prkce)) -> p(RGD:Casq2,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10431815

5
value: Finally, we show that calsequestrin is an epsilonprotein kinase C substrate in vitro and protein kinase C phosphorylation of calsequestrin leads to a decreased binding of epsilonprotein kinase C to calsequestrin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10431815

RAEVdY3t5ICSbj9b2sHwANtAuAOL7r0DYP0FhPSa4xXMk
has assertion: p(HGNC:E2F1) -> tscript(p(HGNC:SP1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.845+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:E2F1) -> tscript(p(HGNC:SP1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

5
value: <E25> Sp1 and E2F binding sites are both essential for activation of the murine thymidine kinase promoter (Karlseder et al., 1996). The promoter was activated when the Sp1 and E2F sites were separated by 6 or 10 bp but not when they were separated by 20 bp. The DHFR promoter was strongly activated by Sp1 alone but hardly at all by E2F1 alone (cotransfection in insect cells) (Lin et al., 1996a). E2F1, however, enhanced the activating ability of Sp1, even in the absence of a functional E2F binding site on the promoter.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAABKN0OlKhLAD8avsWKJRexngfVuJ0SXUFX4QV-XpA3s
has assertion: p(HGNC:RB1,pmod(P)) -| complex(p(HGNC:E2F3),p(HGNC:RB1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.851+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:RB1,pmod(P)) -| complex(p(HGNC:E2F3),p(HGNC:RB1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

6
value: <E2> Unphosphorylated (or hypophosphorylated) pRb can bind to DP complexes of E2F1?3 and to a lesser degree E2F4. Binding of pRb family members is mediated by a short, highly conserved domain in the C-terminal region of E2F proteins. The E2F-binding site is in the C-terminal region of pRb.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAI-gZ1klR1ZzqN49mXi7h38Pf6-RZgJqAVAgmRA1Qiy0
has assertion: p(HGNC:RB1,pmod(P)) -| complex(p(PFH:"TFDP Family"),p(HGNC:E2F4),p(HGNC:RB1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.852+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:RB1,pmod(P)) -| complex(p(PFH:"TFDP Family"),p(HGNC:E2F4),p(HGNC:RB1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

7
value: <E2> Unphosphorylated (or hypophosphorylated) pRb can bind to DP complexes of E2F1?3 and to a lesser degree E2F4. Binding of pRb family members is mediated by a short, highly conserved domain in the C-terminal region of E2F proteins. The E2F-binding site is in the C-terminal region of pRb.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAMh256GEp6u5oWEB0Wmox8RIeVhgu0Vz2OAUHisjZNhs
has assertion: p(HGNC:RB1) -| tscript(p(HGNC:E2F4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.873+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:RB1) -| tscript(p(HGNC:E2F4))
label: p(HGNC:RB1,pmod(P)) =| (p(HGNC:RB1) -| tscript(p(HGNC:E2F4)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

7
value: <E7> E2F-DP dimers, complexed with pRb, p107, or p130, can bind and inhibit E2 promoter elements (Dyson, 1998; Mayol and Grana, 1998). In quiescent cells, the predominant complexes contain E2F4 and p130. E2F1_DP:RB1-|taof(E2F1_DP) E2F2_DP:RB1-|taof(E2F2_DP) E2F3_DP:RB1-|taof(E2F3_DP) E2F4_DP:RB1-|taof(E2F4_DP) E2F1_DP:RBL1-|taof(E2F1_DP) E2F2_DP:RBL1-|taof(E2F2_DP) E2F3_DP:RBL1-|taof(E2F3_DP) E2F4_DP:RBL1-|taof(E2F4_DP) E2F1_DP:NOLC1-|taof(E2F1_DP) E2F2_DP:NOLC1-|taof(E2F2_DP) E2F3_DP:NOLC1-|taof(E2F3_DP) E2F4_DP:NOLC1-|taof(E2F4_DP)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAOYLpfEHljM rKjayUJmljq1Dh3XzSE-6WIvu9AZk0GM
has assertion: p(HGNC:RBL1) -| tscript(p(HGNC:E2F3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.882+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:RBL1) -| tscript(p(HGNC:E2F3))
label: p(HGNC:RBL1,pmod(P)) =| (p(HGNC:RBL1) -| tscript(p(HGNC:E2F3)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

7
value: <E7> E2F-DP dimers, complexed with pRb, p107, or p130, can bind and inhibit E2 promoter elements (Dyson, 1998; Mayol and Grana, 1998). In quiescent cells, the predominant complexes contain E2F4 and p130. E2F1_DP:RB1-|taof(E2F1_DP) E2F2_DP:RB1-|taof(E2F2_DP) E2F3_DP:RB1-|taof(E2F3_DP) E2F4_DP:RB1-|taof(E2F4_DP) E2F1_DP:RBL1-|taof(E2F1_DP) E2F2_DP:RBL1-|taof(E2F2_DP) E2F3_DP:RBL1-|taof(E2F3_DP) E2F4_DP:RBL1-|taof(E2F4_DP) E2F1_DP:NOLC1-|taof(E2F1_DP) E2F2_DP:NOLC1-|taof(E2F2_DP) E2F3_DP:NOLC1-|taof(E2F3_DP) E2F4_DP:NOLC1-|taof(E2F4_DP)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAHS1WJ1rq0N csvWG4D0LYwysbq-wcyt8z6IXs-RAlhQ
has assertion: complex(p(HGNC:NOLC1),p(HGNC:E2F1)) => (p(HGNC:NOLC1) -| tscript(p(HGNC:E2F1)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.894+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:NOLC1),p(HGNC:E2F1)) => (p(HGNC:NOLC1) -| tscript(p(HGNC:E2F1)))
label: p(HGNC:NOLC1) -| tscript(p(HGNC:E2F1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

9
value: <E7> E2F-DP dimers, complexed with pRb, p107, or p130, can bind and inhibit E2 promoter elements (Dyson, 1998; Mayol and Grana, 1998). In quiescent cells, the predominant complexes contain E2F4 and p130. E2F1_DP:RB1-|taof(E2F1_DP) E2F2_DP:RB1-|taof(E2F2_DP) E2F3_DP:RB1-|taof(E2F3_DP) E2F4_DP:RB1-|taof(E2F4_DP) E2F1_DP:RBL1-|taof(E2F1_DP) E2F2_DP:RBL1-|taof(E2F2_DP) E2F3_DP:RBL1-|taof(E2F3_DP) E2F4_DP:RBL1-|taof(E2F4_DP) E2F1_DP:NOLC1-|taof(E2F1_DP) E2F2_DP:NOLC1-|taof(E2F2_DP) E2F3_DP:NOLC1-|taof(E2F3_DP) E2F4_DP:NOLC1-|taof(E2F4_DP)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAKgZCpn8LtLKyWu4Gz O1tyQm7VYhyt1-xsApe kFNRE
has assertion: complex(p(HGNC:RBL1),p(HGNC:E2F3)) => (p(HGNC:RBL1) -| tscript(p(HGNC:E2F3)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.902+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:RBL1),p(HGNC:E2F3)) => (p(HGNC:RBL1) -| tscript(p(HGNC:E2F3)))
label: p(HGNC:RBL1) -| tscript(p(HGNC:E2F3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

9
value: <E7> E2F-DP dimers, complexed with pRb, p107, or p130, can bind and inhibit E2 promoter elements (Dyson, 1998; Mayol and Grana, 1998). In quiescent cells, the predominant complexes contain E2F4 and p130. E2F1_DP:RB1-|taof(E2F1_DP) E2F2_DP:RB1-|taof(E2F2_DP) E2F3_DP:RB1-|taof(E2F3_DP) E2F4_DP:RB1-|taof(E2F4_DP) E2F1_DP:RBL1-|taof(E2F1_DP) E2F2_DP:RBL1-|taof(E2F2_DP) E2F3_DP:RBL1-|taof(E2F3_DP) E2F4_DP:RBL1-|taof(E2F4_DP) E2F1_DP:NOLC1-|taof(E2F1_DP) E2F2_DP:NOLC1-|taof(E2F2_DP) E2F3_DP:NOLC1-|taof(E2F3_DP) E2F4_DP:NOLC1-|taof(E2F4_DP)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RALRd6gZaOllXt0SxxxER6XLuVsPhs-Aitsdh7ER2UPOQ
has assertion: tscript(p(HGNC:RB1)) =| tscript(p(HGNC:E2F1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.904+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:RB1)) =| tscript(p(HGNC:E2F1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

6
value: <E7> E2F-DP dimers, complexed with pRb, p107, or p130, can bind and inhibit E2 promoter elements (Dyson, 1998; Mayol and Grana, 1998). In quiescent cells, the predominant complexes contain E2F4 and p130. E2F1_DP:RB1-|taof(E2F1_DP) E2F2_DP:RB1-|taof(E2F2_DP) E2F3_DP:RB1-|taof(E2F3_DP) E2F4_DP:RB1-|taof(E2F4_DP) E2F1_DP:RBL1-|taof(E2F1_DP) E2F2_DP:RBL1-|taof(E2F2_DP) E2F3_DP:RBL1-|taof(E2F3_DP) E2F4_DP:RBL1-|taof(E2F4_DP) E2F1_DP:NOLC1-|taof(E2F1_DP) E2F2_DP:NOLC1-|taof(E2F2_DP) E2F3_DP:NOLC1-|taof(E2F3_DP) E2F4_DP:NOLC1-|taof(E2F4_DP)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RACsTWJiEFWSXCx1 p4ZbiXFBg26zJPsLGdFk YyrVzMM
has assertion: bp(GO:"histone acetylation") -> complex(p(HGNC:GADD45A),p(PFH:"Histone Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.911+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"histone acetylation") -> complex(p(HGNC:GADD45A),p(PFH:"Histone Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

5
value: Gadd45 binds to core histones in chromatin or nucleosomes whose structure has been loosened by acetylation or UV light (UV) radiation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAKfr7JHQ2SH2pg0NQtSg7KceaYmzFi2RAiZCIUKS3kCk
has assertion: cat(p(HGNC:CREBBP)) => bp(GO:"histone acetylation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.914+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CREBBP)) => bp(GO:"histone acetylation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

4
value: p300 and CBP have intrinsic histone acetyl transferase activity
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAKJsmB7is7vlI5rrOcqZ8CI3A38 KNKUYl wGMeMYwt4
has assertion: complex(p(HGNC:TP53),p(HGNC:TP53),p(HGNC:TP53),p(HGNC:TP53)) -> tscript(p(HGNC:TP53))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.920+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:TP53),p(HGNC:TP53),p(HGNC:TP53),p(HGNC:TP53)) -> tscript(p(HGNC:TP53))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

9
value: <p17> Ser392 phosphorylation of P53 increases 10-fold the association constant for tetramerization, but this effect is reversed by Ser315 phosphorylation. The tetramerization activates P53 for specific DNA binding and transcription
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RABoVdH5VwXAwMvyGA4AjR7AQaBt7jyOMVl-rLZoHwl1Y
has assertion: p(HGNC:MDM2) =| tscript(p(HGNC:TP53))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.923+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MDM2) =| tscript(p(HGNC:TP53))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

5
value: <p29> mdm2 inhibits p53-mediated transactivation; it inhibits the expression of p53 dependent genes
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAMjrvCyz6bqdnRbOQUimip8mY1vjYH2TXBOQN3p39uqs
has assertion: p(HGNC:MDM2) => tscript(p(HGNC:E2F1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.926+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:MDM2) => tscript(p(HGNC:E2F1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436023

5
value: <p35> Mdm2 binds with E2F1:TFDP1 - this enhances the transcriptional activity of E2F1:TFDP1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436023

RAIildcYxYAQkRDkq3jZ6Z070ZzxjGP4Hw2S6oINabJxg
has assertion: p(RGD:Fgf2) -> gtp(p(RGD:Tubb3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.949+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Fgf2) -> gtp(p(RGD:Tubb3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436062

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436062

RAN5NuXW-305tSmUyO8vSs3QE34Ay6lialOCwN38pYF24
has assertion: p(HGNC:EGF) -> p(PFH:"Histone H3 Family",pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.951+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> p(PFH:"Histone H3 Family",pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436156

4
value: Rsk-2, a member of the pp90rsk family of kinases implicated in growth control, was required for epidermal growth factor (EGF)-stimulated phosphorylation of H3
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436156

RAHbRgmStl9ssb-oH6Wd4GUBRl11aHgDABZ jW5yleQws
has assertion: a(CHEBI:"nitric oxide") -| tscript(p(HGNC:ELK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.959+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -| tscript(p(HGNC:ELK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436166

4
value: This inhibitory effect was further substantiated by the inhibition of NO on both the shear stress-induced transcriptional activity of Elk-1 (an ERK substrate)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436166

RAMDdO2tsTXoEOV6YHYy09ct05iFL glel91shviFeIZM
has assertion: cat(p(HGNC:NOS3)) -| tscript(p(HGNC:ELK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.960+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:NOS3)) -| tscript(p(HGNC:ELK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436166

6
value: This inhibitory effect was further substantiated by the inhibition of NO on both the shear stress-induced transcriptional activity of Elk-1 (an ERK substrate)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436166

RAK0OBeYUX1-k4uDU4TlGrawiUHUTIknhtSZLB74P9oyc
has assertion: a(CHEBI:"nitric oxide") -| r(HGNC:EGR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.965+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -| r(HGNC:EGR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10436166

3
value: Treatment of ECs with an NO donor, S-nitroso-N-acetylpenicillamine (SNAP) or 3-morpholinosydnonimine (SIN-1), inhibited this shear stress-induced Egr-1 expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10436166

RAMWtKOx6d6AxCfyoq6a7cfZlARFcVACNS-9S2B70hrJw
has assertion: p(HGNC:NGF) -> r(HGNC:CCND1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.974+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:CCND1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10438538

4
value: Furthermore, it has been shown that NGF induces cyclin D1 expression in PC12 cells ( 64 ).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10438538

RADFUpPkopib9GfQWvAZ2imqe6Tg9JBO6jGMLsxDr4JkQ
has assertion: p(HGNC:IL2) -> p(HGNC:TNFSF10)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.977+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL2) -> p(HGNC:TNFSF10)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10438925

4
value: Molecular mechanisms for the restricted induction of TRAIL expression on NK cells by IL-2 or IL-15 remain to be determined.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10438925

RAIiPSkBtzEoMt-M0Vzw0hY3H82UDmIrigWaRfPyxNkzM
has assertion: p(MGI:Ifng) -> p(MGI:Fgf2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.980+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ifng) -> p(MGI:Fgf2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10438928

4
value: The combination of the inflammatory cytokines IL-1 beta, TNF-alpha, and IFN-gamma, synergized with Tat to promote the development of angioproliferative KS-like lesions in nude mice that are not observed with each factor alone. Injection of inflammatory cytokines IL-1beta, TNF-alpha and IFN-gamma was found to cause an increase in the expression of bFGF and VEGF. However, bFGF, but not VEGF, synergizes with Tat in vivo and induces endothelial cells to migrate, to adhere, and to grow in response to Tat in vitro. Tat angiogenic effects correlate with the expression of the alpha v beta 3 integrin that is induced by bFGF and binds the arginine-glycine-aspartic acid (RGD) region of Tat.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10438928

RAMPLke-yHEloGS0oZ9lmvHgIdp5 hEt9GMs1PWe1BXrg
has assertion: p(MGI:Tnf) -> p(MGI:Vegfa)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:47.986+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Tnf) -> p(MGI:Vegfa)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10438928

4
value: The combination of the inflammatory cytokines IL-1 beta, TNF-alpha, and IFN-gamma, synergized with Tat to promote the development of angioproliferative KS-like lesions in nude mice that are not observed with each factor alone. Injection of inflammatory cytokines IL-1beta, TNF-alpha and IFN-gamma was found to cause an increase in the expression of bFGF and VEGF. However, bFGF, but not VEGF, synergizes with Tat in vivo and induces endothelial cells to migrate, to adhere, and to grow in response to Tat in vitro. Tat angiogenic effects correlate with the expression of the alpha v beta 3 integrin that is induced by bFGF and binds the arginine-glycine-aspartic acid (RGD) region of Tat.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10438928

RABJjXpKboojn1rRgHy-G8W-8lP2NL-gPn Asim3L7pfk
has assertion: p(HGNC:IL1B) -| p(HGNC:TFRC)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.002+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL1B) -| p(HGNC:TFRC)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10444519

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10444519

RAIFAR1XXuckEtF-LSxIyC42UdHEyyVAk6iUH2Gg6nED8
has assertion: cat(complex(p(HGNC:ITGA6),p(HGNC:ITGB1))) -| p(HGNC:PXN)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.006+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(complex(p(HGNC:ITGA6),p(HGNC:ITGB1))) -| p(HGNC:PXN)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

7
value: Certain integrins may regulate proliferation by additional mechanisms. For example, the a6b1 integrin may in part promote exit from the cell cycle in myoblasts, because the cytoplasmic domain of a6 inhibits paxillin signaling (44).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAA66PXpJMF0KGbUYH1xNtIVNb3yTGOjsYDY6ZCNjE1Sc
has assertion: kin(p(HGNC:PTK2)) -> kin(p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.017+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PTK2)) -> kin(p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

6
value: FAK also combines with, and may activate, phosphoinositide 3-OH kinase (PI 3-kinase), either directly or through the Src kinase (13). Finally, there is evidence that Src phosphorylates FAK at Tyr925, creating a binding site for the complex of the adapter Grb2 and Ras guanosine 5'-triphosphate exchange factor mSOS (10). These interactions link FAK to signaling pathways that modify the cytoskeleton and activate mitogen-activated protein kinase (MAPK) cascades (Fig. 3A).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAIeFn7OHS0JJ6RG 6YZKlyGh2qpRzjmTYUDfu9koju6k
has assertion: p(HGNC:TP53) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.020+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TP53) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

3
value: FAK appears to play a major role in conveying survival signals from the ECM (50, 51). Because FAK binds PI 3-kinase, the protective effect against anoikis may be the result of PI 3-kinase-mediated activation of protein kinase B/Akt (52). Akt promotes survival, at least in part, by phosphorylating and thereby inactivating two proapoptotic proteins, Bad and caspase-9 (53) (Fig. 4). Inhibition of p53 prevents FAKdeficient cells from undergoing anoikis when deprived of growth factors, suggesting that p53 mediates the death signal under FAK deficiency (51).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAMJcAlcYr RN7Voba6R6c DdJ1F3JnBurYLER9KnQ2QM
has assertion: kin(p(HGNC:AKT1)) =| p(HGNC:BAD)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.024+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:AKT1)) =| p(HGNC:BAD)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

5
value: FAK appears to play a major role in conveying survival signals from the ECM (50, 51). Because FAK binds PI 3-kinase, the protective effect against anoikis may be the result of PI 3-kinase-mediated activation of protein kinase B/Akt (52). Akt promotes survival, at least in part, by phosphorylating and thereby inactivating two proapoptotic proteins, Bad and caspase-9 (53) (Fig. 4). Inhibition of p53 prevents FAKdeficient cells from undergoing anoikis when deprived of growth factors, suggesting that p53 mediates the death signal under FAK deficiency (51).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAEZe6bD43erhv5pLrJstKhsIb0QyLkumg5DHA1fJCQeI
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.026+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

3
value: FAK appears to play a major role in conveying survival signals from the ECM (50, 51). Because FAK binds PI 3-kinase, the protective effect against anoikis may be the result of PI 3-kinase-mediated activation of protein kinase B/Akt (52). Akt promotes survival, at least in part, by phosphorylating and thereby inactivating two proapoptotic proteins, Bad and caspase-9 (53) (Fig. 4). Inhibition of p53 prevents FAKdeficient cells from undergoing anoikis when deprived of growth factors, suggesting that p53 mediates the death signal under FAK deficiency (51).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAKXd8qL3nsjkBY9DlEor6gPb851OB-x7snIJFuOD8ACI
has assertion: complex(p(HGNC:PTK2),p(HGNC:SRC)) => kin(p(HGNC:SRC))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.033+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:PTK2),p(HGNC:SRC)) => kin(p(HGNC:SRC))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

7
value: FAK may be recruited to nascent focal adhesions because it interacts, either directly or through the cytoskeletal proteins talin and paxillin, with the cytoplasmic tail of integrin b subunits (8). Upon activation, FAK autophosphorylates Tyr397, creating a binding site for the Src homology 2 (SH2) domain of Src or Fyn (9, 10). The Src kinase then phosphorylates a number of focal adhesion components. The major targets include paxillin and tensin, two cytoskeletal proteins that may also have signaling functions, and p130CAS, a docking protein that recruits the adapter proteins Crk and Nck (11, 12).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAJ5QDPk5gC685fVKUcjXLfZgpWrOicSo7YEUscOirywg
has assertion: gtp(p(HGNC:RAC1)) -> a(SCHEM:Lamellipodiae)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.040+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:RAC1)) -> a(SCHEM:Lamellipodiae)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

4
value: Integrins and receptors for soluble mitogens, such as lysophosphatidic acid and growth factors, regulate cell spreading and migration through activation of the Rho-family of small guanine nucleotide-binding proteins (57). Among the Rho-related guanosine triphosphatase, Cdc42 induces filopodia, Rac induces lamellipodia, and Rho induces focal adhesions and associated stress fibers.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAEPhvt8O2V1Ao1jHvgxnoFztJZmQu6A87-cBR dwquXk
has assertion: bp(GO:"cell adhesion") -> bp(GO:"cell cycle")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.041+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"cell adhesion") -> bp(GO:"cell cycle")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

2
value: Rac promotes cell cycle progression, an effect that correlates with its ability to organize the cytoskeleton and promote spreading, rather than with its ability to activate MAP kinases (63).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAL1erJ0Fw3wxcTRIi4fpXp-w5zI0W07xkRezWY8xXQbk
has assertion: p(HGNC:FN1) => cat(complex(p(HGNC:ITGA5),p(HGNC:ITGB1)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.049+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:FN1) => cat(complex(p(HGNC:ITGA5),p(HGNC:ITGB1)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

7
value: The a5b1 integrin, which binds to fibronectin, induces expression of the antiapoptotic protein Bcl-2, protecting cells from apoptosis from stresses such as the lack of growth factors (55). Other integrins, including another fibronectin receptor, avb1, do not provide this survival effect. The avb3 integrin promotes endothelial and melanoma cell survival; this effect correlates with suppression of the p53 pathway and activation of the nuclear factor kappa B transcription factor (56). The activation of Shc by a1b1, a5b1, and avb3 may also contribute to protection from apoptosis (4, 17). Thus, integrinmediated attachment to ECM is a general requirement for cell survival, but survival under special circumstances may require a particular integrin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAHGt-k3yV3DNFrOWH0f08Y-gSsbGWcmOdNgBiRytH8fU
has assertion: cat(complex(p(HGNC:ITGAV),p(HGNC:ITGB3))) -| (p(HGNC:TP53) -> bp(MESHPP:Apoptosis))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.051+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(complex(p(HGNC:ITGAV),p(HGNC:ITGB3))) -| (p(HGNC:TP53) -> bp(MESHPP:Apoptosis))
label: p(HGNC:TP53) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

8
value: The a5b1 integrin, which binds to fibronectin, induces expression of the antiapoptotic protein Bcl-2, protecting cells from apoptosis from stresses such as the lack of growth factors (55). Other integrins, including another fibronectin receptor, avb1, do not provide this survival effect. The avb3 integrin promotes endothelial and melanoma cell survival; this effect correlates with suppression of the p53 pathway and activation of the nuclear factor kappa B transcription factor (56). The activation of Shc by a1b1, a5b1, and avb3 may also contribute to protection from apoptosis (4, 17). Thus, integrinmediated attachment to ECM is a general requirement for cell survival, but survival under special circumstances may require a particular integrin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RANMOEqNJpZvSAF7WvEzTIk01l VZip3DRxDoyddjMLdM
has assertion: cat(complex(p(HGNC:ITGAV),p(HGNC:ITGB3))) -> tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.055+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(complex(p(HGNC:ITGAV),p(HGNC:ITGB3))) -> tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

7
value: The a5b1 integrin, which binds to fibronectin, induces expression of the antiapoptotic protein Bcl-2, protecting cells from apoptosis from stresses such as the lack of growth factors (55). Other integrins, including another fibronectin receptor, avb1, do not provide this survival effect. The avb3 integrin promotes endothelial and melanoma cell survival; this effect correlates with suppression of the p53 pathway and activation of the nuclear factor kappa B transcription factor (56). The activation of Shc by a1b1, a5b1, and avb3 may also contribute to protection from apoptosis (4, 17). Thus, integrinmediated attachment to ECM is a general requirement for cell survival, but survival under special circumstances may require a particular integrin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RAFlymRrkDog5e0WUAHFaggiUQYicvGQTHfl2KkheHwHw
has assertion: cat(complex(p(HGNC:ITGAV),p(HGNC:ITGB3))) -> kin(p(HGNC:FLT1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.059+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(complex(p(HGNC:ITGAV),p(HGNC:ITGB3))) -> kin(p(HGNC:FLT1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446041

8
value: The receptors for insulin, plateletderived growth factor (PDGF), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) are optimally activated by their ligands only under appropriate cell attachment conditions (24-28). Although a systematic analysis has not been conducted, certain integrins appear to be preferentially associated with specific growth factor receptors. Thus, the avb3 integrin can be immunoprecipitated in complexes with the insulin, PDGF, and VEGF receptors (26, 28), whereas a5b1 and perhaps other b1 integrins associate with the EGF receptor (25, 27).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446041

RADLsEyTFIf0O57j1cB4gxAc9xPKOgiBNGZvAk5wEaIbM
has assertion: p(EGID:183) -> r(HGNC:COL1A1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.065+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:183) -> r(HGNC:COL1A1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446062

4
value: Angiotensin II is an established regulator of vascular tone and smooth muscle cell (SMC) growth. However, there are little data about its effect on collagen synthesis by SMCs and none regarding the mechanism of such an effect. We studied the effect of angiotensin II on collagen production by human arterial SMCs, using uptake of [(3)H]proline into collagenase-digestible proteins, and by ribonuclease protection assay for mRNA encoding the proalpha1 chain of type I collagen, the major collagen in arteries. This revealed a dose-dependent increase in relative collagen synthesis rate and a dose-dependent increase in proalpha1(I) collagen mRNA abundance, with the half-maximal effect at 1.7 nmol/L. Angiotensin II-stimulated collagen expression was associated with a 6-fold increase in transforming growth factor-beta (TGF-beta) production and was inhibited by a neutralizing antibody to TGF-beta. Both collagen production and TGF-beta release were inhibited by the AT(1)-specific antagonist, losartan, but not by the AT(2) receptor antagonist, PD123319. To determined if tyrosine phosphorylation was functionally linked to collagen synthesis, we studied the effect of 2 mechanistically distinct inhibitors of tyrosine kinase, genistein, and tyrphostin A25. These inhibitors abrogated angiotensin II-mediated procollagen mRNA expression and angiotensin II-mediated TGF-beta production, whereas the inactive homolog tyrphostin A1 had no effect. We conclude that angiotensin II stimulates collagen production in human arterial SMCs via the AT(1) receptor and an autocrine loop of TGF-beta, induction of which requires tyrosine phosphorylation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446062

RALPgzoo7c-6YM8WYTbfkZw-CqWLQqtAHB82W vV-WppU
has assertion: kin(p(PFH:"PRKA Family")) => p(HGNC:LCP1,pmod(P,S,11))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.073+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKA Family")) => p(HGNC:LCP1,pmod(P,S,11))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446213

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446213

RAEg2DdiyQp72o -YiqyYK8GvJ4X5nh6IW l207a4cgLI
has assertion: kin(p(HGNC:PRKCD)) -| tscript(p(HGNC:STAT3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.076+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PRKCD)) -| tscript(p(HGNC:STAT3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446219

6
value: Finally, we showed that the phosphorylation of Stat3 by PKC delta led to a negative regulation of Stat3 DNA binding and transcriptional activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446219

RAGAzfRflPWmvklzE0e0G1Yn9RAyLvBjvMnumalejhl5E
has assertion: p(HGNC:IL6) -> complex(p(HGNC:PRKCD),p(HGNC:STAT3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.078+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL6) -> complex(p(HGNC:PRKCD),p(HGNC:STAT3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10446219

6
value: Here, we report that Stat3 was specifically associated with PKC delta in vivo in an IL-6-dependent manner in several cell types.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10446219

RAKyvB-ImeQiYbG9-pooIWEDzw5Nj7qU7bhpZnbBmTv4A
has assertion: p(HGNC:IL17A) -> kin(p(HGNC:JAK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.111+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL17A) -> kin(p(HGNC:JAK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10448060

5
value: interleukin-17 induces time-dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10448060

RAB gkeORKZDYK7Y93FdvAQ3q8WeRgkofW8gnnEaP9 k4
has assertion: complex(p(HGNC:NCOA1),p(HGNC:PGR),a(CHEBI:progesterone)) -> bp(GO:"histone acetylation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.131+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:NCOA1),p(HGNC:PGR),a(CHEBI:progesterone)) -> bp(GO:"histone acetylation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10449719

5
value: ncoa1 possesses intrinsic histone acetyltransferase activity recruitment of coactivator ncoa1 by the ligand-activated PR in vivo leads to chromatin remodeling through histone acetylation and recruitment/stabilization of the preinitiation complex
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10449719

RAHmLVEJ7U7NDIrvL0S3BRtXfX4mbDmOeuecFeF-dXjAw
has assertion: a(CHEBI:progesterone) -> (p(HGNC:NCOA1) -> tscript(p(HGNC:PGR)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.136+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:progesterone) -> (p(HGNC:NCOA1) -> tscript(p(HGNC:PGR)))
label: p(HGNC:NCOA1) -> tscript(p(HGNC:PGR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10449719

6
value: ncoa1 potentiated transcription by ligand-activated PGR, whereas it had no effect on transcription in the absence of ligands
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10449719

RAGM7F0UQmL4E2gZCjW4m2EBV4OILXl6Pjlo0EtXwbY8o
has assertion: a(CHEBI:progesterone) -> (p(HGNC:NCOA1) -> tscript(p(HGNC:PGR)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.138+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:progesterone) -> (p(HGNC:NCOA1) -> tscript(p(HGNC:PGR)))
label: p(HGNC:NCOA1) -> tscript(p(HGNC:PGR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10449719

6
value: ncoa1 potentiated transcription by ligand-activated PGR, whereas it had no effect on transcription in the absence of ligands
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10449719

RAP9wde60AWzS9 kkatAF6u04JNBiNUPZGAlt0oLQWiDo
has assertion: cat(p(RGD:Lepr)) -| cat(p(RGD:Pde2a))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.144+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Lepr)) -| cat(p(RGD:Pde2a))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10452559

6
value: In fa/fa compared to Fa/fa rats, (a) PDE2 activity was significantly increased, (b) Western blot analysis of PDE2 revealed two signals at 71 and 105 kDa, with changes in protein being in good parallelism with changes in activity, (c) the PDE2 mRNA concentration was also significantly increased.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10452559

RAEN54SjjLeuNMCqL1YBBlUnZwFj56fBMMe6KaKJnf2Tg
has assertion: p(MGI:Csf1) -> kin(p(MGI:Mapk3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.147+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Csf1) -> kin(p(MGI:Mapk3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10452980

5
value: M-CSF triggers the activation of extracellular signal-regulated protein kinases (ERK)-1/2.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10452980

RAA KVWL5RgLwigzMhH8pfXt9kfT0Wl68rCVrLONIBSr0
has assertion: p(MGI:Nfkb1) -> p(MGI:Il2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.151+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Nfkb1) -> p(MGI:Il2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10453042

4
value: Splenocytes of control animals proliferated vigorously in response to MOG peptide and produced significant amounts of Th1 (IL2) cytokine. By contrast, splenocytes from NF-KB-deficient (NFKB1) animals produced significantly less amounts of cytokine IL2, and proliferated poorly in response to MOG stimulation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10453042

RADT2dp 0FcvOmdwOGzo4JHE9Y5HVAAvuiVpVtZjXNZfQ
has assertion: tscript(complex(NCH:"Nfkb Complex")) -| cat(p(HGNC:CASP8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.167+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"Nfkb Complex")) -| cat(p(HGNC:CASP8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10454539

5
value: NF-kappaB activation suppresses the activation of caspase 8
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10454539

RAAyh4 ay a8XhbtnLdfWqmS9nfWHzQsZdMER5Nyy6 1A
has assertion: bp(GO:gluconeogenesis) positiveCorrelation path(MESHD:Hyperglycemia)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.173+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:gluconeogenesis) positiveCorrelation path(MESHD:Hyperglycemia)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10454950

2
value: Addition of a sulfonylurea to metformin therapy gives an additive glucose- lowering effect (102, 103,149). Similarly, addition of metformin to sulfonylurea therapy gives an additive response, both with respect to glucose-lowering (101, 103, 149-152) and lipid-lowering (91, 103) effects the elevated fasting plasma glucose level is caused by incomplete suppression of basal hepatic glucose production by sulfonylurea or metformin Figure 1. Pathogenesis of type 2 diabetes mellitus. Sites of action of oral agents are indicated. A negative sign indicates inhibition; a positive sign indicates stimulation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10454950

RAC5nXwB 5dpPWqVUxlktonJsTgd1GjUetZeYn jWMUrs
has assertion: cat(p(HGNC:EDNRA)) -> a(SCHEM:Calcium)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.185+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:EDNRA)) -> a(SCHEM:Calcium)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10455291

4
value: The [Ca2+]i increase induced by ET-1 was inhibited by both BQ123, an ET(A)-receptor antagonist, and BQ788, an ET(B)-receptor antagonist, whereas that induced by ET-3 was inhibited by BQ788 but not by BQ123.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10455291

RALXnL3YXavC38FH0qzpnNh6WlRDfTVSuTBDpbkAlh 9Q
has assertion: kin(p(PFH:"PRKC Family")) -> r(HGNC:PTGIS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.201+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> r(HGNC:PTGIS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10458930

5
value: BK increased cPLA(2) mRNA eightfold by 15 min, and this increase was inhibited by pretreatment with the PKC inhibitors.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10458930

RAATzFBwUa6DLGf7ORg3LMSUzfLnq0gaesnJ ONnk4CXs
has assertion: kin(p(PFH:"PRKC Family")) -> a(SCHEM:Calcium)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.207+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> a(SCHEM:Calcium)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10458930

4
value: The PKC inhibitors GF109203X and H7 attenuated the BK-induced increase in [Ca(2+)](i) and inhibited the BK-induced PGI(2) synthesis. Phorbol 12-myristate 13-acetate increased cPLA(2) activity and PGI(2) synthesis but failed to alter [Ca(2+)](i).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10458930

RAP8IgkJ1BRpBIqjlv2PNkMDMlKgeofGXpnL3pHLeST-A
has assertion: kin(p(PFH:"PRKC Family")) -> cat(p(HGNC:PTGIS))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.208+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> cat(p(HGNC:PTGIS))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10458930

6
value: The PKC inhibitors GF109203X and H7 attenuated the BK-induced increase in [Ca(2+)](i) and inhibited the BK-induced PGI(2) synthesis. Phorbol 12-myristate 13-acetate increased cPLA(2) activity and PGI(2) synthesis but failed to alter [Ca(2+)](i).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10458930

RACnhm4qdHNfpohLDvQhF9RSqsChrcHUUeFi0E1cnC8l4
has assertion: kin(p(PFH:"PRKC Family")) -> a(SCHEM:Calcium)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.223+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> a(SCHEM:Calcium)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10458930

4
value: The PKC inhibitors GF109203X and H7 attenuated the BK-induced increase in [Ca(2+)](i) and inhibited the BK-induced PGI(2) synthesis. Phorbol 12-myristate 13-acetate increased cPLA(2) activity and PGI(2) synthesis but failed to alter [Ca(2+)](i).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10458930

RAJu4hsVp-3CcT0zZBpsnW53SCjcEidTtjb6pHCPw7wCA
has assertion: kin(p(PFH:"PRKC Family")) -> cat(p(HGNC:PTGIS))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.225+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> cat(p(HGNC:PTGIS))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10458930

6
value: The PKC inhibitors GF109203X and H7 attenuated the BK-induced increase in [Ca(2+)](i) and inhibited the BK-induced PGI(2) synthesis. Phorbol 12-myristate 13-acetate increased cPLA(2) activity and PGI(2) synthesis but failed to alter [Ca(2+)](i).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10458930

RACxrXVINkjNMsyNXnrKnGcB95KekV27feg8vr5S8wFY8
has assertion: path(MESHD:Hyperoxia) -> r(HGNC:CDKN1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.227+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Hyperoxia) -> r(HGNC:CDKN1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10460757

3
value: Furthermore, high oxygen levels induce S-phase arrest and increased expression of p53 and p21(WAF1/CIP1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10460757

RADmzi1fMZBWzSjqcBpo1yFL45EEpBZr7DK24JqW5cOsM
has assertion: path(MESHD:Hyperoxia) -> a(SCHEM:"free radical")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.230+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Hyperoxia) -> a(SCHEM:"free radical")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10460757

2
value: Hyperoxia increases free radical production, leading to DNA damage.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10460757

RAHgi2l6-94WbpDgZRwj8wNeZVZ eYzOe Q81SuZXyk24
has assertion: cat(p(HGNC:NOS2)) -| r(HGNC:FMO1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.236+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:NOS2)) -| r(HGNC:FMO1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10462538

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10462538

RAKnbwOCOS4zheMGGKaF1j9CR0CecDphfjXPMxNbIrbFs
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:CD69)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.237+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:CD69)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10464057

3
value: % Thus the PMA-induced expression of CD11b and CD69 in human PMN represents two separate processes
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10464057

RAJr0A4d BayuCXCugYHK1hCifeLSjJAfVCDX4948HMso
has assertion: gtp(p(HGNC:ARF6)) -> (p(HGNC:INS) -> sec(p(HGNC:CFD)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.242+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:ARF6)) -> (p(HGNC:INS) -> sec(p(HGNC:CFD)))
label: p(HGNC:INS) -> sec(p(HGNC:CFD))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10464254

8
value: In contrast, the secretion of adipsin, a serine protease specifically expressed in adipocytes, was increased by the expression of wild-type ARF6 and was inhibited by the expression of D125N. These results indicate a requirement for ARF6 in basal and insulin-regulated adipsin secretion but not in glucose transport.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10464254

RAOr-oDLInXIjA--TlWDm7iu8TyZV4twq-qgS6WGJzlks
has assertion: p(HGNC:IL6ST) -> kin(p(HGNC:LYN))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.245+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL6ST) -> kin(p(HGNC:LYN))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10464281

5
value: Ariadne: GRP58 is a major target for tyrosine phosphorylation by the Lyn kinase ( 76 ), a kinase that can be activated by IL-6 through gp130 signaling
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10464281

RALrpP4VxgxZ cRJG9QIT5QlnmPhvWtkrBqy07 zkCZyU
has assertion: kin(p(HGNC:LYN)) => p(HGNC:PDIA3,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.247+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:LYN)) => p(HGNC:PDIA3,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10464281

5
value: Ariadne: GRP58 is a major target for tyrosine phosphorylation by the Lyn kinase ( 76 ), a kinase that can be activated by IL-6 through gp130 signaling
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10464281

RADrnIgA9dUV-TlO6qoHXYxv4OznTalE1dPfZVQXem9rI
has assertion: complex(NCR:"Ngf Complex") -> tscript(complex(NCR:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.254+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(NCR:"Ngf Complex") -> tscript(complex(NCR:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10467349

3
value: In comparison, overexpression of atypical PKC-iota was by itself sufficient to activate NF-kappaB and shift the kinetics of NGF-induced kappaB activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10467349

RACbgHQ LGLBreoDhfESulUdjQPYYNvvamg6tH86QBdWo
has assertion: a(CHEBI:epoxomicin) -| tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.255+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:epoxomicin) -| tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10468620

3
value: Epoxomicin also effectively inhibits NF-kappaB activation in vitro and potently blocks in vivo inflammation in the murine ear edema assay.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10468620

RAP8-lW43g-yniy2l0e2-ocagFJ-278JuE RCWPTUDut8
has assertion: a(CHEBI:cisplatin) -> r(HGNC:ICAM1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.257+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:cisplatin) -> r(HGNC:ICAM1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10469360

3
value: Renal CD54 mRNA expression was markedly increased by 24 hours after exposure to cisplatin in mice.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10469360

RAPFCKbkRvKYaO3IYqxaUYGPTJl4ZcZYWQUD5M2uV6dhg
has assertion: cat(p(HGNC:CASP3)) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.258+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CASP3)) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10470376

4
value: Also cathepsin L participates in cell apoptosis mediated by caspase III activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10470376

RAAeQiBTeB928tSoacgD01xz1VJTxvMZqDKp0M5j-8bcU
has assertion: a(CHEBI:lipopolysaccharide) -> r(RGD:Cebpb)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.260+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:lipopolysaccharide) -> r(RGD:Cebpb)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10470496

3
value: Northern blot analysis showed an increased abundance of the mRNA for C/EBP beta in LPS-treated lungs and for C/EBP delta in Bleo-treated lungs
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10470496

RAH3DmWVHN4A6AUt4Q6M0QyVAlfsSUhHtiGIwzRtIlD5o
has assertion: gtp(p(HGNC:RAC1)) => complex(p(HGNC:CDC42),p(HGNC:IQGAP1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.278+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:RAC1)) => complex(p(HGNC:CDC42),p(HGNC:IQGAP1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10473551

7
value: Guanosine 5'-(3-O-thio)triphosphate (GTPgammaS).glutathione S-transferase (GST)-Cdc42 and GTPgammaS. GST-Rac1 inhibited the binding of IQGAP1 to beta-catenin in a dose-dependent manner in vitro
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10473551

RAD4b4J2MKm7poOLLTshXaJT9JwJ6i AjHclU4AGzw0e4
has assertion: tscript(p(HGNC:PPARG)) -| tscript(complex(NCH:"AP-1 Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.299+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:PPARG)) -| tscript(complex(NCH:"AP-1 Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10473669

5
value: These results indicate that both PPAR{alpha} and PPAR{gamma} interfere with AP-1 transcriptional activity in a manner independent of the promoter context.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10473669

RAKDOCrdSp4zc VS59EnlglzCVvv6svkgzgJkdKivnHiw
has assertion: p(HGNC:NGF) -> r(HGNC:HIST1H2BO)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.315+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:HIST1H2BO)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10477751

4
value: Note that both panels are reprobes of the same blot. d, In vitro Akt activation using histone H2B as a substrate in lysates of sympathetic neurons treated for 15 min with increasing concentrations of NGF (ng/ml) or KCl (mM).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10477751

RAGxRIqloAo6AZMEUILNX357DLclT6MZF hl0Ql1r37tM
has assertion: kin(p(MGI:Adrbk1)) -| cat(p(MGI:Fshr))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.319+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Adrbk1)) -| cat(p(MGI:Fshr))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10478849

6
value: GRK2, -3, -5, -6a, and -6b inhibit the FSH-R-mediated signaling
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10478849

RAHn2yIwlCu23bnoD767mo-1Y-EJuq1oIR7SiJpHCRSl4
has assertion: kin(p(PFH:"PRKC Family")) -> p(HGNC:TFPI)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.324+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> p(HGNC:TFPI)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10479670

5
value: Northern blot analysis of TFPI mRNA also showed a decrease of the 1.4-kb transcript after 4 hours of incubation with UFH, followed by recovery and an increase over the control level after 24 hours. Incubation of ECs with phorbol ester (PMA) significantly enhanced the secretion of TFPI and increased its activity on the cell surface, probably by preventing invagination of caveolae.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10479670

RAIa7v3TkPE5P CSv n0lHYXZ3oVMgqe2Q Ty8WbXokNA
has assertion: kin(p(PFH:"PRKC Family")) -> sec(p(HGNC:TFPI))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.326+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> sec(p(HGNC:TFPI))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10479670

6
value: Northern blot analysis of TFPI mRNA also showed a decrease of the 1.4-kb transcript after 4 hours of incubation with UFH, followed by recovery and an increase over the control level after 24 hours. Incubation of ECs with phorbol ester (PMA) significantly enhanced the secretion of TFPI and increased its activity on the cell surface, probably by preventing invagination of caveolae.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10479670

RAPsgARnvdhwHS9k4 SEFhCny9TvEK7oplW-YxjXY61UQ
has assertion: tscript(p(MGI:Tbx2)) -| r(MGI:Tyrp1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.335+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Tbx2)) -| r(MGI:Tyrp1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10480898

5
value: Previous work has established that the melanocyte-specific tyrosinase-related protein-1 (TRP-1) promoter is regulated positively by the microphthalmia-associated transcription factor Mitf, acting through the conserved M box and negatively by the T-box factor Tbx2,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10480898

RAKhY9n9o-Pa7k6yOEWEDIrRRf1s3Weqp8n50ZdEYq5TI
has assertion: kin(p(HGNC:MAPK1)) -> kin(p(HGNC:RPS6KA3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.340+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) -> kin(p(HGNC:RPS6KA3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10480933

6
value: Its (RSK2) activation requires phosphorylation of the linker region at Ser(369), catalyzed by extracellular signal-regulated kinase (ERK)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10480933

RAO0aQYvyUYuQBq0bOt6W-Cl-3s5zbCMTK-fuOfCQIKIs
has assertion: path(SDIS:"tissue damage") -> r(MGI:Dsc2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.343+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"tissue damage") -> r(MGI:Dsc2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10482015

3
value: freshly excised human skin specimens.At all stages studied the entire set of desmosomal cadherins [desmogleins (Dsg) 1-3 and desmocollins (Dsc) 1-3] was detected, with Dsg3, Dsc2 and Dsc3 being the most prominent.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10482015

RANSaEyCXdhd9pEUhGHZVP2wIuxh66WBKKweR9QeEuyq0
has assertion: path(SDIS:"tissue damage") -> r(MGI:Dsg1a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.350+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"tissue damage") -> r(MGI:Dsg1a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10482015

3
value: freshly excised human skin specimens.At all stages studied the entire set of desmosomal cadherins [desmogleins (Dsg) 1-3 and desmocollins (Dsc) 1-3] was detected, with Dsg3, Dsc2 and Dsc3 being the most prominent.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10482015

RAIfj5tmp7T SCA2okhOPUnb5bXHHwwMvYrQgd0t3tRG8
has assertion: path(SDIS:"tissue damage") -> r(MGI:Dsg3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.355+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"tissue damage") -> r(MGI:Dsg3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10482015

3
value: freshly excised human skin specimens.At all stages studied the entire set of desmosomal cadherins [desmogleins (Dsg) 1-3 and desmocollins (Dsc) 1-3] was detected, with Dsg3, Dsc2 and Dsc3 being the most prominent.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10482015

RAK9QSVdk1-M9GzZQMBWYUmi1ydq-JbZ4Qmz-tk9eL8K0
has assertion: a(CHEBI:"nitric oxide") -> p(MGI:Pln,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.358+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> p(MGI:Pln,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10484417

3
value: Also, in rat aorta, nitric oxide-induced relaxation via the cGMP kinase pathway was associated with phosphorylation of PLB
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10484417

RAHDDuTsHFCt6zlG4gI-fkoxkHGtiPMzoFZuu-kVCfC64
has assertion: p(HGNC:TP53,sub(R,273,H)) =| tscript(p(HGNC:TP53))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.364+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

1
has substitution: R,273,H
variant of: http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11998
type: http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000

p(HGNC:TP53,sub(R,273,H)) =| tscript(p(HGNC:TP53))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10485447

5
value: From mutations file
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10485447

RAC7CTXA u6W9t69Hkcl2Amv6frq61p4Zt2YdAPVtcxQA
has assertion: a(CHEBI:androgen) -> r(HGNC:TMPRSS2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.366+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:androgen) -> r(HGNC:TMPRSS2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10485450

3
value: TMPRSS2 as a gene exhibiting increased expression upon exposure to androgens
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10485450

RAJyk7zmweEjokBpZZs6ZEgx-NOoaNO1mL8RrS-O atic
has assertion: gtp(p(HGNC:RAC1)) -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.412+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:RAC1)) -> a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10486263

4
value: Upon stimulation, a functional NADPH oxidase is assembled when the cytosolic proteins, Rac, p67phox, p47phox, and possibly p40phox, associate with the gp91phox and p22phox transmembrane proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10486263

RANV0KPdCe -MsModIA0RfShIvmpK0D118FBQbZVQd0KI
has assertion: phos(p(HGNC:PTPN6)) -| kin(p(HGNC:PIK3R1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.430+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(HGNC:PTPN6)) -| kin(p(HGNC:PIK3R1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10488096

6
value: Wild-type but not catalytically inactive SHP-1 induced dephosphorylation of p85. Furthermore, expression of SHP-1 decreased PI3K enzyme activity in anti-phosphotyrosine immunoprecipitates and phosphorylation of serine 473 in Akt, a process dependent on PI3K activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10488096

RAPwX6eVjY3XAzZq-X-j0iyaZii2b5D1nQsS61idw2eKs
has assertion: p(HGNC:TXN) -> tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.435+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TXN) -> tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10488136

4
value: In the cytoplasm, it interferes with the signals to IkappaB kinases and blocks the degradation of IkappaB. In the nucleus, however, TRX enhances NF-kappaB transcriptional activities by enhancing its ability to bind DNA.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10488136

RAMxnbxI6kzGv8qhPtPdOWORVm5mv3TkfUYphxB1TXuQs
has assertion: complex(p(HGNC:CDC42EP3),p(HGNC:RHOQ)) -| gtp(p(HGNC:CDC42))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.454+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:CDC42EP3),p(HGNC:RHOQ)) -| gtp(p(HGNC:CDC42))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10490598

7
value: Borg1, Borg2, Borg4, and Borg5 bind both TC10 and Cdc42 in a GTP-dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10490598

RAMaGZ6MbmkF9WdCss-LaFcGYnfu93eN-RHl-lTzqlBJQ
has assertion: cat(p(MGI:Traf6)) -> kin(p(MGI:Mapk8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.461+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(MGI:Traf6)) -> kin(p(MGI:Mapk8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10490605

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10490605

RAKF1kJKtAiO0bavoWXKLUQwljLp1Ft0V2-nBXLWM5viI
has assertion: kin(p(MGI:Raf1)) -> kin(p(MGI:Mapk1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.493+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Raf1)) -> kin(p(MGI:Mapk1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10490655

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10490655

RAKnWdc OO6UMylRcHyFyf9qvlfp8ppNUxYrGmAGUpBrg
has assertion: complex(p(HGNC:APPL1),p(HGNC:AKT2),p(HGNC:PIK3CA)) -> (kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> kin(p(HGNC:AKT2)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.508+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:APPL1),p(HGNC:AKT2),p(HGNC:PIK3CA)) -> (kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> kin(p(HGNC:AKT2)))
label: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> kin(p(HGNC:AKT2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10490823

10
value: These data suggest that APPL is an adaptor that may tether inactive AKT2 to p110alpha in the cytoplasm and thereby may expedite recruitment of AKT2 and p110alpha to the cell membrane upon mitogenic stimulation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10490823

RAB14b7B0Dkv5efAju1T3YEq54uCWRDajFBoE-gFzLJx8
has assertion: p(HGNC:TNF) -> sec(p(HGNC:CCL3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.515+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> sec(p(HGNC:CCL3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10490959

5
value: TNF-alpha stimulates secretion of RANTES, MIP-1beta and MIP-1alpha by HIV-infected alveolar macrophages and peripheral blood monocytes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10490959

RAGZR3dH39-fw2x5SVCdeoIGCE-sSLp5Add0qrJwJ-wMY
has assertion: kin(p(PFR:"Prkc Family")) -> r(RGD:Col1a1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.525+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFR:"Prkc Family")) -> r(RGD:Col1a1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10493907

5
value: In addition, TGFbeta(1)- and BMP-2-induced increases in alpha1(I) collagen mRNA levels were both dependent on protein kinase C and protein tyrosine kinase activities.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10493907

RAHxwJAT2X0E6FFXZIHBlvUMbYF7cPGjD9-w7zmQZP4HI
has assertion: a(CHEBI:"angiotensin II") -> r(MGI:Tgfbr2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.526+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"angiotensin II") -> r(MGI:Tgfbr2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10494801

3
value: ANG II upregulates TGF-beta receptor type II expression on proximal tubular cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10494801

RAEyS1RIMu3USnRHYBmsHoI7wfGhdVln0ZliWHLe7z4Sk
has assertion: a(SCHEM:Prasterone) -> r(MGI:Cyp1b1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.548+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Prasterone) -> r(MGI:Cyp1b1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10497882

3
value: Treatment of intact C3H10T1/2 cells or microsomes therefrom with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzanthracene (BA) enhanced CYP1B1 activity and CYP1B1 expression as revealed by elevations of CYP1B1-catalyzed DMBA metabolism, CYP1B1 apoprotein level and CYP1B1 gene expression. One hundred microM DHEA caused an 80-90% inhibition of cellular DMBA metabolism without inflicting cell death. Cytosolic glucose-6-phosphate dehydrogenase (G6PDH) was also inhibited in DHEA-treated cells, presumably due to the inhibition of NADP reduction. In contrast, neither DMBA metabolism nor CYP1B1 apoprotein was inhibited by DHEA in the microsomes isolated from these cells. DHEA (100 microM), TCDD (10 nM) and BA (10 microM) stimulated the activities and increased the apoprotein levels of two peroxisomal enzymes, namely, acyl CoA oxidase (ACOX) and acyl CoA hydrolase (ACH2) and also induced the expression of CYP1B1 and ACOX genes. Cytosolic fatty acyl-CoA beta-oxidation was also stimulated by DHEA, TCDD and BA. In corroboratory experiments, it was found that concomitant with the stimulation of the activity of a key enzyme regulator of fatty acid homeostasis, namely, glycerol-3-phosphate dehydrogenase (G3PDH), these agents enhanced arachidonic acid (AA) metabolism as judged by the release of [3H] from AA into the culture medium. Collectively, these data suggest that DHEA mediates the regulation of CYP1B1 and inhibits BA and TCDD-induced CYP1B1-catalyzed carcinogen (DMBA) activation in 10T1/2 cells through metabolic interactions that involve the activation of the peroxisomal and fatty acid beta-oxidation signaling pathways. These results also present evidence for the first time, for the possible peroxisomal effects of TCDD and BA which are similar to those of DHEA in this mouse embryo fibroblast cell line.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10497882

RAOZLrY QxRJM0rkbpkJgx1Ijrmz5qq5Myw8-jp013b9k
has assertion: complex(p(RGD:Npy1r),p(RGD:Npy)) -> path(SDIS:"food intake")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.552+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(RGD:Npy1r),p(RGD:Npy)) -> path(SDIS:"food intake")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10499503

5
value: The results showed that intracerebroventricular administration of NPY stimulated feeding and increased immunostaining of c-Fos, a product of the immediate early gene c-fos
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10499503

RANXWJJGwc1H0FviLbP3VVQOFajhHzPvYGL2BAqjux6mc
has assertion: p(HGNC:IL18BP) -| p(HGNC:IFNG)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.562+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL18BP) -| p(HGNC:IFNG)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10500212

4
value: Ability of huIL18bp to inhibit IFNgamma induction was shown by incubating human KG-1 monocytic cells with IL-18. MC53L and MC54L blocked IFNgamma production at nanogram levels in a dose dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10500212

RAKXkhO2G-UYPOi3Y7ak1neLUAD2Rmra1 dSuVc5WbfQI
has assertion: p(RGD:Nos3) -> a(SCHEM:"Cyclic GMP")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.564+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Nos3) -> a(SCHEM:"Cyclic GMP")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10500231

3
value: cGMP concentrations were increased significantly in penile tissue of rats transfected with AdCMVeNOS compared with control.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10500231

RAJKOu xSUpaJi-eOzSrD9-idnJc5-sLsCUhCtdygcn94
has assertion: p(PFH:"TGFB Family") -> r(HGNC:CSF2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.568+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFH:"TGFB Family") -> r(HGNC:CSF2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10503948

4
value: On the other hand, TGF-beta stimulated the expression of both MCP-I and GM-CSF, but suppressed M-CSF expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10503948

RAKFMzkO0mwyGmkgRzPDd88MkQ-YtAlataNmL49u4IqGA
has assertion: p(MGI:Bmp6) -> p(MGI:Smad5,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.572+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Bmp6) -> p(MGI:Smad5,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10504300

4
value: BMP6 induced the phosphorylation of Smad5 and Smad1 in C2C12 cells and MC3T3-E1 cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10504300

RAMVjhQ4lojs2oUuCU MXMJW1wmR9Qmp16PQeJqhi5Gqk
has assertion: a(CHEBI:fenofibrate) -> r(HGNC:ABCD3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.574+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:fenofibrate) -> r(HGNC:ABCD3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10504404

3
value: Dietary fenofibrate had no effect on the ALD and P70R genes, but strongly increased expression of the ALDR and PMP70 genes in mouse liver.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10504404

RABPs3o9A00TdlhsZwOuOEsPPA9rn3c50iNaR5DCbT OU
has assertion: tscript(p(HGNC:HOXA5)) =| r(HGNC:DST)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.575+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:HOXA5)) =| r(HGNC:DST)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10504454

5
value: Engrailed, Hoxa-5, and Hoxc-8 regulate BPAG1e promoter activity
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10504454

RANmALfFTd5AoArZW 7ZnYnNEhAL2IYEhyxb0vcNpHyqI
has assertion: p(HGNC:HBEGF) -> cat(p(HGNC:GPC1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.578+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:HBEGF) -> cat(p(HGNC:GPC1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10505759

5
value: The glypican- antisense transfected clones displayed markedly reduced glypican- protein levels and a marked attenuation of the mitogenic responses to heparin-binding growth factors that are commonly overexpressed in pancreatic cancer: fibroblast growth factor-2 (FGF2), heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), and hepatocyte growth factor (HGF)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10505759

RAIqaTb2Cry4Nkjxpk7rT JIwu8mnigP8A9XeNLruKPgE
has assertion: complex(p(HGNC:HGF),p(HGNC:GPC1)) -> bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.581+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:HGF),p(HGNC:GPC1)) -> bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10505759

5
value: The glypican- antisense transfected clones displayed markedly reduced glypican- protein levels and a marked attenuation of the mitogenic responses to heparin-binding growth factors that are commonly overexpressed in pancreatic cancer: fibroblast growth factor-2 (FGF2), heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF), and hepatocyte growth factor (HGF)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10505759

RAFDoYW2zmbEHu4DLA4wlsmI8g-3mM2JxZWcDyxTD8BYY
has assertion: a(SCHEM:Colforsin) -| r(HGNC:BGLAP)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.584+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Colforsin) -| r(HGNC:BGLAP)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10506130

3
value: # sentences for pubmedID=10506130: # Ariadne: Results showed that forskolin also inhibited the expression of alkaline phosphatase, bone sialoprotein, osteopontin, and osteocalcin genes (Fig. 2 C ). [Expression]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10506130

Selventa

RAEV6uUEAB7j-Xgn5fkCnKhsXUNBUAIa2n0-cgGoJnqqk
has assertion: a(SCHEM:"cyclic AMP") -| r(HGNC:IBSP)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.590+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -| r(HGNC:IBSP)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10506130

3
value: # sentences for pubmedID=10506130: # Ariadne: Results showed that forskolin also inhibited the expression of alkaline phosphatase, bone sialoprotein, osteopontin, and osteocalcin genes (Fig. 2 C ). [Expression]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10506130

Selventa

RAJ8v2ZbQu54RMIm971uzRJJ XSi0312gU8t4E4nxiTYY
has assertion: a(SCHEM:"cyclic AMP") -| tscript(p(HGNC:RUNX2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.594+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -| tscript(p(HGNC:RUNX2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10506130

4
value: In the osteoblastic cell line, MC3T3-E1, continuous treatment with cAMP elevating agents inhibited both osteoblastic differentiation based on alkaline phosphatase assay and DNA binding ability of Cbfa1 based on a gel retardation assay. Cbfa1 inhibition was paralleled by an inhibitory effect of forskolin on Cbfa1-regulated genes. Northern and Western blot analyses suggested that the inhibition of Cbfa1 by forskolin was mainly at the protein level.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10506130

Selventa

RAJyY7o- fFliM8fZoJrc3n4lu7PXBD eDCsNdA9pSdE
has assertion: kin(p(HGNC:CDK2)) -> phos(p(HGNC:PPP1CA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.606+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:CDK2)) -> phos(p(HGNC:PPP1CA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10506210

6
value: In this study, we examined the cell cycle-dependent phosphorylation of PP1alpha in vivo using three different antibodies. PP1alpha was phosphorylated at Thr-320 during M-phase and again in late G(1)- through early S-phase. Inhibition of Cdk2 led to a small increase in PP1 activity and also prevented PP1alpha phosphorylation. In vitro, PP1alpha was a substrate for Cdk2 but not Cdk4.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10506210

Selventa

RAOnsYnCTnUdY7VHlwMQvPgAoI4BCSZWBwkEMS0WyQ3KE
has assertion: cat(p(RGD:Agtr1b)) -> kin(p(RGD:Mapk8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.612+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr1b)) -> kin(p(RGD:Mapk8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10506481

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10506481

Selventa

RAEz8ZTyPdnn6nMa2o6bExlnvXIIBxB5zxMBWkyUKOO54
has assertion: path(MESHD:Ischemia) -> a(CHEBI:peroxynitrite)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.639+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Ischemia) -> a(CHEBI:peroxynitrite)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10508238

2
value: These changes lead to the activation of five damaging events, termed perpetrators. These are the damaging actions of free radicals and their product peroxynitrite,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10508238

Selventa

RAIjVU6DEdVhXSG1QxWqoih3miGvf-dNcvZ6Hxmo9DenQ
has assertion: path(MESHD:Ischemia) -> bp(GO:"pH reduction")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.644+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(MESHD:Ischemia) -> bp(GO:"pH reduction")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10508238

2
value: decreased pH,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10508238

Selventa

RANHDzhZtuZyG8PT0Bo5TZuKHhDQZvcamd00FjwHHQcLI
has assertion: bp(GO:"replicative cell aging") -| r(HGNC:ALDH1A1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.656+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"replicative cell aging") -| r(HGNC:ALDH1A1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10508581

3
value: Figure 2. Differential gene expression at senesence.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10508581

Selventa

RAKaaWgrkj7L96Nm-WJrFXI-joNT3ScxysRIBzFlNFO6c
has assertion: p(RGD:Foxa3) -> r(RGD:Hgf)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.667+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Foxa3) -> r(RGD:Hgf)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10508906

4
value: As shown in Fig. 3, Northern blot analysis showed that the HGF levels were slightly increased in the CCl4-treated livers of the mock- and AxCALacZ-infected rats compared with those of normal rat livers. In contrast, a dramatic increase in HGF expression was observed in the rat liver infected with HNF3gamma (1.5×109 pfu).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10508906

Selventa

RAFLz fHG95p3FstT4NeRaczP8fvoaSM7FCI5FsSHLQ1c
has assertion: tscript(p(RGD:Foxa3)) -| p(EGID:24817)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.672+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(RGD:Foxa3)) -| p(EGID:24817)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10508906

5
value: Fig. 4 shows the results of the Northern blot analysis, which indicate that endogenous HNF-3? mRNA (indicated with an arrow) was decreased 50% in the CCl4-injured liver compared with the normal rat. However, the transduced HNF-3gamma mRNA (indicated with an arrowhead) was increased dose-dependently by the AxCAHNF3gamma infection in spite of CCl4 treatment. HNF-3alpha and HNF-3beta were up-regulated in the CCl4-treated livers of mock- and AxCALacZ-infected rats. Conversely, These mRNAs in the AxCAHNF3gamma-infected liver were not observed to be induced by CCl4 treatment.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10508906

Selventa

RAPeeBPKm72uf8Ew1UIGnINYyMJMKZILJ uA N3-4Wk1M
has assertion: cat(p(RGD:Agtr1b)) -| cat(p(RGD:Mmp2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.687+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr1b)) -| cat(p(RGD:Mmp2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10512375

6
value: We conclude that glucose increases AII production by mesangial cells, which results in stimulation of TGF-beta1 secretion, decreased matrix degradation, and increased matrix accumulation. These effects of AII are mediated by the AT1 receptor. Collagenase activity in cell medium was determined using three methods: 1) zymography; 2) quantitative assay using fluoresceinated gelatin as substrate; and 3) a new enzyme-linked immunosorbent assay (ELISA) that specifically measures 72-kDa collagenase (MMP-2), the principal collagenase synthesized by mesangial cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10512375

Selventa

RAOY54V8yC UI71 XHGM-ZyUll-ty0trwrxHiRadIQpAw
has assertion: cat(p(RGD:Agtr2)) -| cat(p(RGD:Mmp2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.691+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr2)) -| cat(p(RGD:Mmp2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10512375

6
value: We conclude that glucose increases AII production by mesangial cells, which results in stimulation of TGF-beta1 secretion, decreased matrix degradation, and increased matrix accumulation. These effects of AII are mediated by the AT1 receptor. Collagenase activity in cell medium was determined using three methods: 1) zymography; 2) quantitative assay using fluoresceinated gelatin as substrate; and 3) a new enzyme-linked immunosorbent assay (ELISA) that specifically measures 72-kDa collagenase (MMP-2), the principal collagenase synthesized by mesangial cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10512375

Selventa

RAAt7NxjcG7XH-tDaoWPaoSnvByz0TEUdbVnAwTuqqfKY
has assertion: cat(p(RGD:Agtr2)) -> sec(p(RGD:Tgfb1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.693+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr2)) -> sec(p(RGD:Tgfb1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10512375

6
value: We conclude that glucose increases AII production by mesangial cells, which results in stimulation of TGF-beta1 secretion, decreased matrix degradation, and increased matrix accumulation. These effects of AII are mediated by the AT1 receptor. Collagenase activity in cell medium was determined using three methods: 1) zymography; 2) quantitative assay using fluoresceinated gelatin as substrate; and 3) a new enzyme-linked immunosorbent assay (ELISA) that specifically measures 72-kDa collagenase (MMP-2), the principal collagenase synthesized by mesangial cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10512375

Selventa

RAKmNWHhH5xa btqso5upjTeJO8S6328lt6-LBYc5wQxU
has assertion: tscript(p(PFH:"TCF/LEF Family")) -> r(HGNC:MMP7)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.700+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(PFH:"TCF/LEF Family")) -> r(HGNC:MMP7)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10514384

5
value: Here we report the identification of the matrix metalloproteinase MMP-7 as another target gene of beta-catenin/TCF-4. MMP-7 is overexpressed in 80% of human colorectal cancers and known to be an important factor for early tumor growth, with a potential function also for later progression steps, like invasion and metastasis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10514384

Selventa

RABjzLG4M76KJfwQxesze9-WeV10TH jUVf-VBB9qY0LE
has assertion: gtp(p(PFH:"RAS Family")) -| r(HGNC:PAWR)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.712+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(PFH:"RAS Family")) -| r(HGNC:PAWR)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10514481

5
value: Oncogenic Ras induces the transcription activity of NF-kappaB that confers cell survival. Oncogenic Ras also down-modulates the expression of Par-4, a transcriptional repressor protein, that is essential but not sufficient on its own to induce apoptosis. Here we show that reintroduction of Par-4 by transient transfection leads to apoptosis in cells expressing oncogenic Ras but not in those that lack oncogenic Ras expression. Par-4 abrogates oncogenic Ras-inducible NF-kappaB transcription activity
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10514481

Selventa

RAHyUvC3Rl5J2ToT9bilH2rcXqvARLRCv1vL3NE7wK0xc
has assertion: gtp(p(HGNC:HRAS)) -> tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.716+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:HRAS)) -> tscript(complex(NCH:"Nfkb Complex"))
label: tscript(p(HGNC:PAWR)) -| (gtp(p(HGNC:HRAS)) -> tscript(complex(NCH:"Nfkb Complex")))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10514481

8
value: Oncogenic Ras induces the transcription activity of NF-kappaB that confers cell survival. Oncogenic Ras also down-modulates the expression of Par-4, a transcriptional repressor protein, that is essential but not sufficient on its own to induce apoptosis. Here we show that reintroduction of Par-4 by transient transfection leads to apoptosis in cells expressing oncogenic Ras but not in those that lack oncogenic Ras expression. Par-4 abrogates oncogenic Ras-inducible NF-kappaB transcription activity
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10514481

Selventa

RANK689Z0gxg56K 8qVmxyVYOepq4gnDobEI3ppb19vYE
has assertion: p(MGI:Epo) -> tscript(p(MGI:Elk1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.725+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Epo) -> tscript(p(MGI:Elk1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10514505

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10514505

Selventa

RAB1vqGmH8 pZNfxlQuajCeuJ3NzcmWEemsKUKy2Sh4uk
has assertion: p(MGI:Rapgef1) -> tscript(p(MGI:Elk1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.726+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Rapgef1) -> tscript(p(MGI:Elk1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10514505

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10514505

Selventa

RAGwBxc1F9JucZ0OQKpEVALiGrjg6L5bDISBnTH -AeuY
has assertion: tscript(complex(NCH:"AP-1 Complex")) => r(HGNC:GCLC)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.732+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"AP-1 Complex")) => r(HGNC:GCLC)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10515588

4
value: ECV304 cells transiently transfected with a plasmid containing the gamma-GCS promoter-luciferase construct showed increased luciferase activity when treated with melatonin. The melatonin-dependent luciferase activity was found in the gamma-GCS promoter containing AP-1 site
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10515588

Selventa

RAFzU4NDechJFiCCWHPl4EvQe1sEA0DsRfp8z7nUQgc94
has assertion: p(HGNC:THPO) -> p(HGNC:TEC,pmod(P,T))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.736+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:THPO) -> p(HGNC:TEC,pmod(P,T))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10515871

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10515871

Selventa

RADmnl8vJsM3ZJobRXKrn9TL77lGzdmdi8D7CdT2RPPrw
has assertion: a(SCHEM:"cyclic AMP") -> r(HGNC:MMP2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.738+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -> r(HGNC:MMP2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10515879

3
value: By contrast, G-protein inhibition by pertussis toxin, or transfection with a dominant negative mutant of Ha-Ras strongly increased fibronectin-induced MMP-2 and MMP-9. Inhibition of PI3 kinase, MAPkinase (MEK1), or p38 MAPkinase by wortmannin, PD 98059, or SB 202190, respectively, strongly promoted fibronectin-induced MMP2 and MMP-9
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10515879

Selventa

RABCfqjkZtY3L3KAG7H2HKHiQBb4hqFwggkdbVjxGJEMQ
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| r(HGNC:MMP2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.754+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| r(HGNC:MMP2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10515879

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10515879

Selventa

RAHdaxx8yp3LZ0DDGrS-y8nolpwvZ0JBghEI7q7oTjS5I
has assertion: a(CHEBI:"reactive oxygen species") -> r(MGI:Prdx1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.757+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -> r(MGI:Prdx1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10517540

3
value: Using differential screening, we cloned two novel proteins designated MSP23 and A170 that are induced in the cells by low levels of reactive oxygen species, electrophilic agents and other oxidative stress agents
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10517540

Selventa

RAPFFFng5bMKFTmzvopaY0Wik41BF907QjMnESXUQUduw
has assertion: cat(p(PFM:"Hdac Family")) -> (p(MGI:Trp53) -> bp(MESHPP:Apoptosis))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.794+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(PFM:"Hdac Family")) -> (p(MGI:Trp53) -> bp(MESHPP:Apoptosis))
label: p(MGI:Trp53) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10521394

6
value: Significantly, inhibition of p53-mediated transcriptional repression with TSA markedly inhibits apoptosis induction by p53.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10521394

Selventa

RAEZt3foMbdIIEAVlQO5-HvlSU16f8lNq0lIGxL5SRWoI
has assertion: cat(p(PFM:"Hdac Family")) -| r(MGI:Stmn1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.804+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(PFM:"Hdac Family")) -| r(MGI:Stmn1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10521394

5
value: We report that trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs), abrogates the ability of p53 to repress the transcription of two genes that it negatively regulates, Map4 and stathmin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10521394

Selventa

RAJmZVrX62Fj6GYKrKmCdy-CO1L7oXtG4JxH3rVTp9Wj8
has assertion: cat(p(PFM:"Hdac Family")) -| r(MGI:Stmn1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.807+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(PFM:"Hdac Family")) -| r(MGI:Stmn1)
label: tscript(p(MGI:Trp53)) -> (cat(p(PFM:"Hdac Family")) -| r(MGI:Stmn1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10521394

8
value: We report that trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs), abrogates the ability of p53 to repress the transcription of two genes that it negatively regulates, Map4 and stathmin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10521394

Selventa

RAIlZRWxolo8dq O-jo7YgMHD Y7zCWTo9usIugj7kFOc
has assertion: kin(p(HGNC:MAPK1)) => p(HGNC:STAT3,pmod(P,S,727))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.839+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) => p(HGNC:STAT3,pmod(P,S,727))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10521505

5
value: Recently, serine phosphorylation of Stat3 on Ser-727 by ERK has been identified in response to epidermal growth factor (EGF).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10521505

Selventa

RAIsVMFsqTLncrfQApPBwICKDC4DrKe1r4CDIKgU4DZzc
has assertion: kin(p(PFH:"MAPK JNK Family")) -| p(HGNC:STAT3,pmod(P,Y,705))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.841+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"MAPK JNK Family")) -| p(HGNC:STAT3,pmod(P,Y,705))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10521505

5
value: We further demonstrate that JNK1, activated by its upstream kinase MKK7, negatively regulated the tyrosine phosphorylation and DNA binding and transcriptional activities of Stat3 stimulated by EGF.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10521505

Selventa

RAF9LEImTEo-14fHdXlHE4nTCYmbl1Enz1DvgovNjI8pg
has assertion: p(MGI:Ccr2) -> path(SDIS:"Atherosclerotic lesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.900+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ccr2) -> path(SDIS:"Atherosclerotic lesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10525042

3
value: In addition, in recent in vivo studies, targeted disruption of the genes for MCP-1, CCR2, and CXCR2 significantly decreased atherosclerotic lesion formation and lipid deposition when the disrupted gene was bred or transferred into mouse strains prone to develop atherosclerotic-like lesions (36, 37, 29).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10525042

Selventa

RAC5X KajV7lxV6Aj 0KQLXbjfdyMel8-9CA84pKslFKI
has assertion: p(HGNC:TNF) -> p(HGNC:CXCR3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.903+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> p(HGNC:CXCR3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10525042

4
value: In vitro experiments supported these results and showed that IL-1beta, TNF-alpha, and CD40 ligand potentiated IP-10 expression from IFN-gamma-stimulated ECs.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10525042

Selventa

RAOz4uYWKZTciZF On8jhlBHmz3hXboiBRGmlqAtiNquA
has assertion: a(SCHEM:Calcium) -> r(HGNC:NDRG1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.908+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> r(HGNC:NDRG1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10527911

3
value: We report here that the Ca(2+) ionophore A23187 substantially stimulated Cap43 gene expression. In addition, we found that BAPTA-AM, a specific chelator of free intracellular Ca(2+), consistently attenuated the induction of Cap43, indicating that elevation of intracellular Ca(2+) was essential for this response
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10527911

Selventa

RAHCHzdYAF SCwOHVETu J1qikJb0OQzTW8VlQFeMz4B4
has assertion: kin(p(PFH:"PRKC Family")) => p(HGNC:CYTH2,pmod(P,S,392))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.915+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) => p(HGNC:CYTH2,pmod(P,S,392))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10531036

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10531036

Selventa

RAO4xU oy8OUrtM3LCbYY49oo61ai-OiT3UjwqvvCyQTY
has assertion: p(HGNC:NGF) -| r(HGNC:NRG1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.939+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -| r(HGNC:NRG1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10532805

4
value: In PC12 cells, nerve growth factor induces neuronal differentiation and repressed expression of nrg-1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10532805

Selventa

RAImQsuoFTQ0BHfdnQva eYngtiQyECk7rW-K5Iw9n05w
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(EGID:305843)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.951+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(EGID:305843)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10537159

3
value: Insulin inhibited the stimulatory effect of a high level of glucose (25 mM) and phorbol 12-myristate 13-acetate, an activator of protein kinase C) on the secretion of ANG and the expression of the ANG messenger RNA in IRPTC.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10537159

Selventa

RAG-QluizTb7zJj6CF6vzbq4y2Tx9nxZXm kZWy9P6eDo
has assertion: a(SCHEM:"serum glucose") -> sec(p(EGID:305843))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.954+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum glucose") -> sec(p(EGID:305843))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10537159

4
value: Insulin inhibited the stimulatory effect of a high level of glucose (25 mM) and phorbol 12-myristate 13-acetate, an activator of protein kinase C) on the secretion of ANG and the expression of the ANG messenger RNA in IRPTC.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10537159

Selventa

RAIGF3cBtfQ9od7VxOFOlLWdfRCjDxC2eLITibGOiBQFQ
has assertion: a(SCHEM:"serum glucose") -> r(EGID:305843)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.956+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum glucose") -> r(EGID:305843)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10537159

3
value: Insulin inhibited the stimulatory effect of a high level of glucose (25 mM) and phorbol 12-myristate 13-acetate, an activator of protein kinase C) on the secretion of ANG and the expression of the ANG messenger RNA in IRPTC.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10537159

Selventa

RAEzSdwikEQ9YxG sSu6okFy7srybz31iPjg59 rqBLxs
has assertion: kin(p(PFR:"Prkc Family")) -> sec(p(EGID:305843))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.961+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFR:"Prkc Family")) -> sec(p(EGID:305843))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10537159

6
value: Insulin inhibited the stimulatory effect of a high level of glucose (25 mM) and phorbol 12-myristate 13-acetate, an activator of protein kinase C) on the secretion of ANG and the expression of the ANG messenger RNA in IRPTC.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10537159

Selventa

RAB6heTnn5uVaa Wc1kKn-R0Wlbs96vqDzHTKMaA5wRtA
has assertion: kin(p(PFR:"Prkc Family")) -> r(EGID:305843)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.965+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFR:"Prkc Family")) -> r(EGID:305843)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10537159

5
value: Insulin inhibited the stimulatory effect of a high level of glucose (25 mM) and phorbol 12-myristate 13-acetate, an activator of protein kinase C) on the secretion of ANG and the expression of the ANG messenger RNA in IRPTC.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10537159

Selventa

RAPozelO3VjlUjrjbcApF3QmHMoC23-iFjXFeHL4wN4rI
has assertion: p(HGNC:TNF) -> sec(p(HGNC:CFB))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.980+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> sec(p(HGNC:CFB))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10540155

5
value: sodium butyrate enhanced TNF-alpha-induced C3 secretion, but suppressed TNF-alpha-induced factor B and IL-8 secretion.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10540155

Selventa

RAKkrL1xCfWAWxAHaS0-7qOZWOwgp7s2gY-CCd8NZnFJQ
has assertion: p(HGNC:IL10) -| tscript(complex(NCH:"Nfkb Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.992+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL10) -| tscript(complex(NCH:"Nfkb Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542212

4
value: In this study, we show that IL-10 functions to block NF-kappaB activity at two levels: 1) through the suppression of IKK activity and 2) through the inhibition of NF-kappaB DNA binding activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542212

Selventa

RAIAe-rMkGOaZ6R8NM5 XCFi4oOPv6I107Bw28BVebs2M
has assertion: a(CHEBI:"okadaic acid") -| p(MGI:Ccnd2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:48.997+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"okadaic acid") -| p(MGI:Ccnd2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542219

3
value: Okadaic acid and calyculin A had no effect on pRB phosphatase activity even though PP2A was completely inhibited. The decrease in pRB phosphorylation correlated with inhibitor-induced suppression of G(1) cyclin-dependent kinases including CDK2, CDK4, and CDK6. The inhibitors also caused decreases in the levels of cyclin D2 and cyclin E, and induction of the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542219

Selventa

RAB1RFpKQSan30IUJYh956KCbjyJWBmTGj31WCaA3jiIw
has assertion: cat(p(HGNC:DAB2IP)) =| gtp(p(PFH:"RAS Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.006+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:DAB2IP)) =| gtp(p(PFH:"RAS Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542228

6
value: After activating Ras using EGF The presence of EGF increased the reporter gene activity at least 5-fold. However, DIP1/2 could inhibit the reporter gene activity in a dose-dependent manner.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542228

Selventa

RAJXVuwk6ioOyeTCoKIIUHG9lEalxZvyQgZd9qZMuer3A
has assertion: complex(p(PFH:"RAS Family"),a(SCHEM:"Guanosine triphosphate")) => gtp(p(PFH:"RAS Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.008+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(PFH:"RAS Family"),a(SCHEM:"Guanosine triphosphate")) => gtp(p(PFH:"RAS Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542228

6
value: Because Raf binds tightly to the GTP-bound form of Ras but not to the GDP-bound form, such differential affinity can be used to determine the GTP-bound status of Ras.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542228

Selventa

RAM6QXfrIJRV89l9p8bZzdMmV1frwXttl-gQZVsoQR9hU
has assertion: gtp(p(PFH:"RAS Family")) => kin(p(PFH:"RAF Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.012+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(PFH:"RAS Family")) => kin(p(PFH:"RAF Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542228

6
value: Because Raf binds tightly to the GTP-bound form of Ras but not to the GDP-bound form, such differential affinity can be used to determine the GTP-bound status of Ras.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542228

Selventa

RAInnD6zx-bYT0RaF3QfRWD2M0jQWkke96qqVx23RZ9lo
has assertion: cat(p(PFH:"SOS Family")) => gtp(p(PFH:"RAS Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.016+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(PFH:"SOS Family")) => gtp(p(PFH:"RAS Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542228

6
value: DOC-2/DAB2 and DIP1/2 complex represent a negative feedback machinery for several exogenous stimuli-elicited signal cascade. PKC can phosphorylate the N-terminal domain of DOC-2/DAB2 (serine 24) that recruits DIP1/2 to inactivate Ras protein. On the other hand, shortly after the treatment of peptide growth factors, the C terminus of DOC-2/DAB2 (proline-rich domain) competes with SOS for Grb 2 binding, which leads to the inactivation of the MAP pathway.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542228

Selventa

RAD79r6mwnATuOXeHpAVjFnq958ffqmZBb5WCg-BAvxA0
has assertion: kin(p(HGNC:PRKCB)) => p(HGNC:DAB2,pmod(P,S,24))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.019+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PRKCB)) => p(HGNC:DAB2,pmod(P,S,24))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542228

5
value: DOC-2/DAB2, a novel phosphoprotein with signal-transducing capability, inhibits human prostatic cancer cells (Tseng, C.-P., Ely, B. D., Li, Y., Pong, R.-C., and Hsieh, J.-T. (1998) Endocrinology 139, 3542-3553). However, its mechanism of action is not understood completely. This study delineates the functional significance of DOC-2/DAB2 protein phosphorylation and demonstrates that in vivo activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24. Mutation of Ser(24) to Ala reduced DOC-2/DAB2 phosphorylation by PKC. Using a synthetic Ser(24) peptide (APS(24)KKEKKKGSEKTD) or recombinant DOC-2/DAB2 as substrates, PKCbetaII, PKCgamma, and PKCdelta (but not casein kinase II) directly phosphorylated Ser(24) in vitro. This indicates that DOC-2/DAB2 is a PKC-specific substrate. Since expression of wild-type DOC-2/DAB2, but not the S24A mutant, inhibited TPA-induced AP-1 activity in prostatic epithelial cells, phosphorylation of Ser(24) appears to play a critical role in modulating TPA-induced AP-1 activity. Taken together, these data suggest that PKC-regulated phosphorylation of DOC-2/DAB2 protein may help its growth inhibitory function.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542228

Selventa

RAB2QEKW7lDDNLzBIRsZzody9D99vXcFkEOb3buFJUYyw
has assertion: kin(p(PFH:"PRKC Family")) => p(HGNC:DAB2,pmod(P,S,24))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.027+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) => p(HGNC:DAB2,pmod(P,S,24))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542228

5
value: activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces DOC-2/DAB2 phosphorylation, including a serine residue at position 24
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542228

Selventa

RANnjjhPXo4c47rXIBBhV0t-4ss87cizi2518 J ZrYgQ
has assertion: p(EGID:183) -> p(HGNC:STAT3,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.043+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:183) -> p(HGNC:STAT3,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10542280

4
value: Angiotensin II induces the tyrosine and serine phosphorylation of Stat1 and Stat3. Under High Glucose condition both the extent and the duration of phosphorylation of Stat1 and Stat3 was increased.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10542280

Selventa

RANpfGieRV8FgJmr bnOl3X6TqXQUR609Ye8JhY3W891s
has assertion: a(CHEBI:androgen) -| r(HGNC:MDM2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.055+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:androgen) -| r(HGNC:MDM2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10547394

3
value: Androgen-independent sublines emerged 80-400 days after androgen withdrawal, and these sublines had variable growth phenotypes but were associated with mdm2 protein overexpression and increased expression of cyclin D1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10547394

Selventa

RADwJPwcjgsDOALiqRefxqC-25 UXrKLc3Vf ZOkhXmsw
has assertion: a(CHEBI:androgen) -> p(HGNC:MKI67)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.056+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:androgen) -> p(HGNC:MKI67)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10547394

3
value: Established tumors in nude athymic BALB/c mice were sampled at various times after androgen withdrawal and after the development of androgen independence. Changes in the expression of cell cycle regulators were categorized into early and mid-to-late events. RESULTS and CONCLUSIONS: Early events included a decrease in androgen receptor expression, followed by a short-term increase in expression of the p53 and p21/WAF1 proteins and a marked decrease in the Ki67 proliferative index.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10547394

Selventa

RAIPc3FHJrISHmmrr33mTZwNWw7mMxXpS19AGEtb1HTYY
has assertion: a(CHEBI:androgen) -| p(HGNC:E2F1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.057+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:androgen) -| p(HGNC:E2F1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10547394

3
value: Mid-to-late events included progressive and sustained increases in p27 and p16 protein expression, a decrease in retinoblastoma protein expression, and an increase in the transcription factor E2F1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10547394

Selventa

RAHMD3 QeKnReQAXBprb kSqN61 NPq ICwZMHmsvHqrk
has assertion: a(CHEBI:androgen) -| r(HGNC:CDKN1B)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.059+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:androgen) -| r(HGNC:CDKN1B)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10547394

3
value: Mid-to-late events included progressive and sustained increases in p27 and p16 protein expression, a decrease in retinoblastoma protein expression, and an increase in the transcription factor E2F1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10547394

Selventa

RAEQA0JBUJYMgAamnBPaZr82pMy8mM2QHurU 0EkVVDT8
has assertion: p(HGNC:S100A9) -> bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.082+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:S100A9) -> bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10551823

3
value: Recently, Newton and Hogg showed that S100A9 stimulates neutrophil adhesion, and S100A8 reversed the stimulatory effect probably by the formation of the heterodimer.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10551823

Selventa

RADFn3mz2yKm2PhUtMa te6p2Bnt7-Z4yzCU9jnL3uMnk
has assertion: p(HGNC:S100A9) -> bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.083+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:S100A9) -> bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10551823

3
value: Recently, Newton and Hogg showed that S100A9 stimulates neutrophil adhesion, and S100A8 reversed the stimulatory effect probably by the formation of the heterodimer.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10551823

Selventa

RAByNvq5FkcdaJu7cXPYilt7MxkkQKzCoNBUsv2KdHxwQ
has assertion: a(SCHEM:Calcium) -> complex(p(HGNC:S100A8),p(HGNC:S100A9),a(CHEBI:"arachidonic acid"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.093+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> complex(p(HGNC:S100A8),p(HGNC:S100A9),a(CHEBI:"arachidonic acid"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10551823

5
value: fatty acid binding was dependent on the calcium concentration;
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10551823

Selventa

RAIJLvGbqsn9m1OyaCXmt9GunaYONHmAaajtFksLHMQ4U
has assertion: cat(p(MGI:Tnfrsf12a)) -| bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.103+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(MGI:Tnfrsf12a)) -| bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10551889

4
value: These experiments revealed that Fn14 expression decreased cellular adhesion to the extracellular matrix proteins fibronectin and vitronectin and also reduced serum-stimulated cell growth and migration
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10551889

Selventa

RAAjrQszgcO7K6GLzFzbftIX-xQ4hvlap0hzo7VFLJFpk
has assertion: a(CHEBI:glucocorticoid) -> r(EGID:113902)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.106+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glucocorticoid) -> r(EGID:113902)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10553012

3
value: Results indicated that the CEH gene has two complex glucocorticoid response units in distal portions of the promoter corresponding to consensus glucocorticoid regulatory sequences as well as putative thyroid hormone response elements.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10553012

Selventa

RAEy1lwYoFAFdk9oEvt8ZAFMmhZD3 TSktldeIIC-MkAc
has assertion: a(CHEBI:ethanol) -| (p(HGNC:PDGFA) -> p(HGNC:PDGFRA,pmod(P)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.131+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:ethanol) -| (p(HGNC:PDGFA) -> p(HGNC:PDGFRA,pmod(P)))
label: p(HGNC:PDGFA) -> p(HGNC:PDGFRA,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10559409

5
value: Ethanol inhibited both PDGF-AA- and PDGF-BB-mediated phosphorylation of PDGFalphar
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10559409

Selventa

RALFsu9FixQkmspGRNYrMjxu5kOJ8JKiFnnJO2RSG5LXU
has assertion: a(CHEBI:ethanol) -| (p(HGNC:PDGFB) -> p(HGNC:PDGFRA,pmod(P)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.133+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:ethanol) -| (p(HGNC:PDGFB) -> p(HGNC:PDGFRA,pmod(P)))
label: p(HGNC:PDGFB) -> p(HGNC:PDGFRA,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10559409

5
value: Ethanol inhibited both PDGF-AA- and PDGF-BB-mediated phosphorylation of PDGFalphar
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10559409

Selventa

RAKcniw-q2a1mQ-7rMR8b6mBmllXbLxu3Xzk6uZUYj91k
has assertion: p(HGNC:CDKN1B,pmod(P,T,187)) -| p(HGNC:CDKN1B)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.138+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CDKN1B,pmod(P,T,187)) -| p(HGNC:CDKN1B)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10559916

4
value: The ubiquitination and subsequent degradation of p27 depend on its phosphorylation by cyclin-CDK complexes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10559916

Selventa

RAG6woh1SxbWnzaXS9 ElX2RTQGykgstCjSBzy01QJrGs
has assertion: kin(p(PFH:"PRKA Family")) => p(HGNC:PTPN7,pmod(P,S,44))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.151+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKA Family")) => p(HGNC:PTPN7,pmod(P,S,44))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10559944

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10559944

Selventa

RALCC9XGXH9UfoJa-5vXit3nrozIvoGKnKQH2cKOZNN20
has assertion: kin(p(PFH:"PRKA Family")) -| complex(p(HGNC:PTPN7),p(HGNC:MAP2K1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.171+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKA Family")) -| complex(p(HGNC:PTPN7),p(HGNC:MAP2K1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10559944

7
value: This modification reduces binding of MAP kinases to the KIM, an effect that is prevented by mutation of serine 23 to alanine.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10559944

Selventa

RAIMzYa7DHB8oDxYM5tiIoLAbybz7TPpEmq1yICUi8ETQ
has assertion: kin(p(PFH:"PRKA Family")) -| complex(p(HGNC:PTPN7),p(HGNC:MAPK3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.181+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKA Family")) -| complex(p(HGNC:PTPN7),p(HGNC:MAPK3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10559944

7
value: This modification reduces binding of MAP kinases to the KIM, an effect that is prevented by mutation of serine 23 to alanine.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10559944

Selventa

RABAKm-jpG7ifN7ydUZXa3dj9vSReI9ABmKQodZmjFAKU
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> (kin(p(PFH:"MAPK Erk1/3 Family")) -| kin(p(HGNC:GSK3A)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.190+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> (kin(p(PFH:"MAPK Erk1/3 Family")) -| kin(p(HGNC:GSK3A)))
label: kin(p(PFH:"MAPK Erk1/3 Family")) -| kin(p(HGNC:GSK3A))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10561508

7
value: PKB alone mediates the IGF1-induced inhibition of GSK3alpha, while the MAPK cascade mediates the inhibition of GSK3alpha by PMA.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10561508

Selventa

RAL VM6zdX9WYePOkxuTE -uMVjvN6Ubc3qvh 4v uYlw
has assertion: kin(p(PFH:"MAPK Erk1/3 Family")) -| kin(p(HGNC:GSK3A))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.192+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"MAPK Erk1/3 Family")) -| kin(p(HGNC:GSK3A))
label: p(HGNC:EGF) -> (kin(p(PFH:"MAPK Erk1/3 Family")) -| kin(p(HGNC:GSK3A)))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10561508

8
value: protein kinase B (PKB) plays a key role in mediating EGF-induced inhibition of GSK3alpha and that the classical MAP kinase (MAPK) cascade has two functions in this process. Firstly, it makes a transient contribution to EGF-induced inhibition of GSK3alpha
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10561508

Selventa

RALK6BOm1fouahKqBLPk MWq W45v1vR0dsvISfPMlpbQ
has assertion: tscript(p(HGNC:HSF2)) => r(HGNC:CCT5)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.202+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:HSF2)) => r(HGNC:CCT5)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10561509

5
value: Whole cell extract of wild-type K562 cells, a transformant cell line of K562 expressing HSF2 and HeLa cells expressing HSF2 transfected with the reporter construct of Ccte gene was found to bind the HSE sequence of Ccte gene, thus activating the Cct gene transcription.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10561509

Selventa

RACVZShkZNVz40-4aJRFk1GJXZfDv2bp17QbrRTWQ2fFo
has assertion: tscript(p(HGNC:HSF2)) => r(HGNC:CCT6A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.206+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:HSF2)) => r(HGNC:CCT6A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10561509

5
value: Whole cell extract of wild-type K562 cells, a transformant cell line of K562 expressing HSF2 and HeLa cells expressing HSF2 transfected with the reporter construct of Cctz-1 gene was found to bind the HSE sequence of Cctz-1 gene, thus activating the Cct gene transcription.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10561509

Selventa

RADkkHEA6QdilVz9EaapozQInbRbUaz904kQcV5xmW9hU
has assertion: p(HGNC:IL10) -| p(HGNC:TNF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.219+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL10) -| p(HGNC:TNF)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10562301

4
value: TNF-alpha and IFN-gamma synthesis was suppressed by IL-10 and TGF-beta
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10562301

Selventa

RAOPejM7BsSOBM2T41eCN7iK8J2fDGCs5EM4VWCkW0ePc
has assertion: p(HGNC:TRIM24) -> bp(GO:"gene silencing")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.231+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TRIM24) -> bp(GO:"gene silencing")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10562550

3
value: The silencing activity of TIF1alpha appears to result chiefly from histone deacetylation, whereas that of TIF1beta may be mediated via both HP1 binding and histone deacetylation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10562550

Selventa

RAIDnF lpiSdZF3idvQVUlskz-q5qNT6YGX4NQF0xBB74
has assertion: cat(p(PFH:"HDAC Family")) -> (p(HGNC:TRIM28) -> bp(GO:"gene silencing"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.237+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(PFH:"HDAC Family")) -> (p(HGNC:TRIM28) -> bp(GO:"gene silencing"))
label: p(HGNC:TRIM28) -> bp(GO:"gene silencing")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10562550

6
value: The silencing activity of TIF1alpha appears to result chiefly from histone deacetylation, whereas that of TIF1beta may be mediated via both HP1 binding and histone deacetylation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10562550

Selventa

RACSKOy7MicslCsWYchuVAXZbZT3 CIuEZEg4j-5KJGdI
has assertion: kin(p(MGI:Acvr1)) -> tscript(p(MGI:Smad1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.243+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Acvr1)) -> tscript(p(MGI:Smad1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10564272

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10564272

Selventa

RAAni0h8Twjq9elWlp88oN230J7fOIWLecOlj6WiNODig
has assertion: kin(p(MGI:Acvrl1)) -> tscript(p(MGI:Smad1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.246+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Acvrl1)) -> tscript(p(MGI:Smad1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10564272

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10564272

Selventa

RAE5Waew9pP937rnyiJPbr 2r-Qk4AWT0QH7OrskAVQcs
has assertion: kin(p(MGI:Bmpr1a)) -> tscript(p(MGI:Smad5))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.247+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Bmpr1a)) -> tscript(p(MGI:Smad5))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10564272

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10564272

Selventa

RAKI9RdRBjabZaLINTbDj np7ODjDYVthI nWV0suyscM
has assertion: kin(p(MGI:Src)) -> p(PFM:"Plcg Family",pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.258+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Src)) -> p(PFM:"Plcg Family",pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10567236

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10567236

Selventa

RAAWknVvi33-1LZkDajLnJVy1sFtTp-EgPAaVNDlfAnJc
has assertion: cat(p(HGNC:PPP1R12A)) -| bp(GO:"muscle contraction")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.260+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:PPP1R12A)) -| bp(GO:"muscle contraction")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10567269

4
value: It is shown here that cGKIalpha is targeted to the smooth muscle cell contractile apparatus by a leucine zipper interaction with the myosin-binding subunit (MBS) of myosin phosphatase. Uncoupling of the cGKIalpha-MBS interaction prevents cGMP-dependent dephosphorylation of myosin light chain, demonstrating that this interaction is essential to the regulation of vascular smooth muscle cell tone.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10567269

Selventa

RAPsMuJPivvOB0LjPdvxrJfTsAR5hitf7OGia0Ur vbG8
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> r(HGNC:PIK3R1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.271+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> r(HGNC:PIK3R1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10567366

4
value: In addition, overexpression of a constitutively active protein kinase B increased p85alphaPI 3-K mRNA levels. These results indicate that the phosphatidylinositol 3-kinase/PKB/p70S6 kinase pathway is required for the stimulation by insulin of p85alphaPI 3-K gene expression in human muscle cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10567366

Selventa

RAHEM9vaha7vyflF4w0A53MVkHNpSY p507Oi jPI9vyk
has assertion: a(CHEBI:clofibrate) -> r(MGI:Acot2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.278+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:clofibrate) -> r(MGI:Acot2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10567408

3
value: Three highly homologous acyl-CoA thioesterase genes, Cte1, Mte1, and Pte1, are located within a narrow cluster on chromosone 12. All four thioesterases are differentially expressed in tissues examined, but all are inducible at mRNA level by treatment with the peroxisome proliferator clofibrate, or during the physiological condition of fasting, both conditions causing a perturbation in overall lipid homeostasis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10567408

Selventa

RAGtF3SKhQUarpCElqalf9EYzEU44rZPCP3ud0xWpnIrE
has assertion: kin(p(MGI:Abl1)) -> path(SDIS:"oncogenic transformation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.283+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Abl1)) -> path(SDIS:"oncogenic transformation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10567556

4
value: DOKL and p62(dok) bind through their PTB domains to the Abelson tyrosine kinase in a kinase-dependent manner in both yeast and mammalian cells. DOKL is phosphorylated by the Abl tyrosine kinase in vivo. In contrast to p62(dok), DOKL lacks YxxP motifs in the C terminus and does not bind to Ras GTPase-activating protein (RasGAP) upon phosphorylation. Overexpression of DOKL, but not p62(dok), suppresses v-Abl-induced mitogen-activated protein (MAP) kinase activation but has no effect on constitutively activated Ras- and epidermal growth factor-induced MAP kinase activation. T
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10567556

Selventa

RAGri48KbYFx6EWp7uzN4i8yEYa6fdSQ1ZedXchpaWcU0
has assertion: p(MGI:Ctbp1) -> tscript(p(MGI:Zeb1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.288+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ctbp1) -> tscript(p(MGI:Zeb1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10567582

5
value: deltaEF1 has a second mechanism of transrepression recruiting CtBP1 or CtBP2 as its corepressor
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10567582

Selventa

RAK4xCG7PDqLY JKXnGW54F0rgIoV4zuQlGgGmEyspClg
has assertion: p(HGNC:APOE) -| complex(p(HGNC:RELN),p(HGNC:LRP8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.319+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:APOE) -| complex(p(HGNC:RELN),p(HGNC:LRP8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10571240

6
value: Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2). Binding requires calcium, and it is inhibited in the presence of apoE.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10571240

Selventa

RAI Cc2SQ4KaF4wCVbXUoHJiqClRceUcoIujC KWPNTzc
has assertion: a(CHEBI:"arachidonic acid") -> r(HGNC:EDN1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.328+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"arachidonic acid") -> r(HGNC:EDN1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10572254

3
value: Arachidonic acid-induced production of ET-1 is dependent on lipoxygenase products of arachidonate metabolism.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10572254

Selventa

RAD5PECT6gq8pzbcNFSVWNxEIDe8ueKPPqHjS5oouU7Do
has assertion: tscript(p(HGNC:KLF10)) -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.330+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:KLF10)) -> a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10573529

4
value: TIEG1 induces apoptosis by a mechanism involving the formation of reactive oxygen species
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10573529

Selventa

RAJs885aClMc2M--my4r7wVBPidKn2pVcm9vlu8B9HIm8
has assertion: kin(p(HGNC:ROCK1)) => p(PFH:"MYL Regulatory Family",pmod(P,S,20))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.333+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:ROCK1)) => p(PFH:"MYL Regulatory Family",pmod(P,S,20))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10574699

5
value: Rho-kinase, an effector of Rho, regulates integrin-mediated cell-substratum adhesion (focal adhesion) by regulating the phosphorylation state of myosin light chain (MLC):
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10574699

Selventa

RAI1JnjcE2EMsD6LbVK5coHOU0hVMxL3tRlI1Yg4Ks8iM
has assertion: kin(p(HGNC:LYN)) -> p(HGNC:PTPN6,pmod(P,Y,564))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.340+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:LYN)) -> p(HGNC:PTPN6,pmod(P,Y,564))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10574931

5
value: The results show that Lyn phosphorylates SHPTP1 at the C-terminal Tyr-564 site. Lyn-mediated phosphorylation of SHPTP1 stimulates SHPTP1 tyrosine phosphatase activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10574931

Selventa

RAOV5 pY4O RbG5McZUiTfPNyfDspBB0iqIQLsGMx9QiA
has assertion: kin(p(HGNC:LYN)) -> phos(p(HGNC:PTPN6))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.342+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:LYN)) -> phos(p(HGNC:PTPN6))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10574931

6
value: The results show that Lyn phosphorylates SHPTP1 at the C-terminal Tyr-564 site. Lyn-mediated phosphorylation of SHPTP1 stimulates SHPTP1 tyrosine phosphatase activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10574931

Selventa

RAN32kOf0dw3avR0GbIQULHvGGBsEHgN24pnnNZk8ekUw
has assertion: kin(p(HGNC:ROCK1)) -> p(HGNC:DES,pmod(P,T,16))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.348+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:ROCK1)) -> p(HGNC:DES,pmod(P,T,16))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10574968

5
value: treatment of the interphase cells with calyculin A revealed phosphorylation at all the three sites of desmin. We also found that an antibody, which specifically recognizes vimentin phosphorylated at Ser-71 by Rho kinase, became immunoreactive after calyculin A treatment.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10574968

Selventa

RAFklA90ugYTrmj2dgjOmJH8wutAQaOnr0hUYwRgbBn3o
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:FAS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.356+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:FAS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10575005

3
value: We further show that anti-CD3 mAb, phorbol 12-myristate 13-acetate, and phorbol 12-myristate 13-acetate/ionomycin strongly activated promoters carrying multiple copies of the Fas enhancer, and mutation of either the GABP or AP-1 binding site severely reduced transcriptional activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10575005

Selventa

RAMBeIlQiTvREHfDUC7eacR6ByDu9r VLSgb0djvhawgY
has assertion: kin(p(HGNC:AKT1)) -| kin(p(HGNC:RAF1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.357+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:AKT1)) -| kin(p(HGNC:RAF1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10576742

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10576742

Selventa

RAP jNh4KPOwMBtUHucj70hc7AdoQr3yZToyW4D5Eg5kM
has assertion: tport(p(HGNC:SCARB1)) => a(SCHEM:"Oxidized High Density Lipoprotein")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.359+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tport(p(HGNC:SCARB1)) => a(SCHEM:"Oxidized High Density Lipoprotein")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10577503

4
value: Scavenger receptors bind and internalize modified low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Because the expression of scavenger receptors is not down-regulated by cholesterol, macrophages (Mphi) expressing scavenger receptors can internalize substantial quantities of cholesteryl ester from oxidized LDL and HDL, leading to foam cell formation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10577503

Selventa

RAOjSMKfUEOQfS-upQzRg0L-7yMfum6sWPc3wRNdeIbMw
has assertion: tloc(p(HGNC:AKT3),GOCCACC:"GO:0005737",GOCCACC:"GO:0005886") -> kin(p(HGNC:AKT3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.373+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tloc(p(HGNC:AKT3),GOCCACC:"GO:0005737",GOCCACC:"GO:0005886") -> kin(p(HGNC:AKT3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10579998

6
value: A consequence of Akt binding to phospholipids is the translocation of Akt from the cytoplasm to the inner surface of the plasma membrane, where PI3K-generated 3'-phosphorylated phospholipids reside Relocalization of Akt to the plasma membrane brings Akt in proximity to regulatory kinases that phosphorylate and activate Akt.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10579998

Selventa

RAJQ7iveis2h3M8ry8g KvRSnRT-nS0tT-oKwNC3bHCAk
has assertion: a(CHEBI:androgen) -| r(HGNC:PEG3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.389+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:androgen) -| r(HGNC:PEG3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10580840

3
value: Treatment with Synthetic Androgen (R1881) resulted in a consistent downregulation of mRNA expression of Peg3 mRNA in LNCaP cells. Combined addition of androgen and actinomycin D revealed no change in the stability of Peg3 mRNA suggesting that androgens decrease Peg3 expression by inhibiting the rate of transcription
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10580840

Selventa

RANS8qmU8jfmBmzi9 9f39sCJcgnt9eoog957tb-qp-ws
has assertion: cat(p(HGNC:DVL1)) -| kin(p(HGNC:EGFR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.396+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:DVL1)) -| kin(p(HGNC:EGFR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10581192

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10581192

Selventa

RAE8upB4fn8CZHOFDJVfqFuUKpEiPbbHheeDhzlrlW0qg
has assertion: a(CHEBI:"trichostatin A") -> r(HGNC:CDKN1A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.403+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"trichostatin A") -> r(HGNC:CDKN1A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10585285

3
value: \"IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells.\"
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10585285

Selventa

RAL3QbgYkBVqRHwzHxtMTFapuk0WmVYB1vo52tizEiNOo
has assertion: p(MGI:Id3) -| tscript(p(MGI:Srebf1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.409+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Id3) -| tscript(p(MGI:Srebf1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10585876

5
value: Gel mobility-shift assays performed with in vitro-translated ADD1, Id2 or Id3 proteins and a fatty acid synthase (FAS) promoter oligonucleotide showed evidence for a marked inhibition of the formation of DNA-ADD1 complexes by Id2 or Id3 proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10585876

Selventa

RAPql9S07hVhdVctC9W-N4Mm41gLbrRzNdOSIXh ywa7I
has assertion: a(SCHEM:Isoproterenol) -> r(MGI:Id2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.418+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Isoproterenol) -> r(MGI:Id2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10585876

3
value: We here demonstrated that there was a dramatic rise of Id2 and Id3 mRNA levels when 3T3-L1 adipocytes or isolated rat fat cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10585876

Selventa

RALx4KtiGY1Cibhw0aDk7zeLSYKsj5kIU60H7LZBTlzjc
has assertion: p(MGI:Cd40) -> p(MGI:Mapk3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.425+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Cd40) -> p(MGI:Mapk3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10586056

4
value: Stimulation of microglial cell lysates with CD40L led to an increase in p42/44MAPK activity. However CD40-CD40L did not induce phosphorylation of p38 MAPK.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10586056

Selventa

RAKcBQ57C5q9F2KiwHHrP11odg59IZruTQOasQvtr7Wzk
has assertion: a(CHEBI:calcitriol) -> surf(p(HGNC:ITGAM))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.431+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:calcitriol) -> surf(p(HGNC:ITGAM))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10587349

4
value: 1alpha,25-dihydroxyvitamin D(3) (D(3)) promotes the maturation of myeloid cells and surface expressions of CD14 and CD11b, markers of cell differentiation in response to D(3).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10587349

Selventa

RAAzqxx9p6MPYA2LBwriMdj4-p36oOvXCEM7pjRzvjIhA
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> r(HGNC:CD14)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.435+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -> r(HGNC:CD14)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10587349

4
value: Furthermore, induction of CD14 expression in response to D(3) was abrogated by (a) the PI 3-kinase inhibitors LY294002 and wortmannin; (b) antisense oligonucleotides to mRNA for the p110 catalytic subunit of PI 3-kinase; and (c) a dominant negative mutant of PI 3-kinase.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10587349

Selventa

RAOsPXeaZXH1LcayDCKyMSC8GBEJJ58fibmMVpennuDI8
has assertion: p(RGD:Avp) -> cat(p(PFR:"Pde4 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.438+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Avp) -> cat(p(PFR:"Pde4 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10588663

5
value: Vasopressin cell stimulation caused a biphasic increase of PDE4 activity
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10588663

Selventa

RAPf2-BnDfjeK2Zwne6f Oi28yaQPEdhEGjxmwexho6UA
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> p(HGNC:SYK,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.449+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> p(HGNC:SYK,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10591686

3
value: PMA at 100 nmol/L strongly potentiated adhesion and tyrosine phosphorylation of p125(FAK) and p72(syk)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10591686

Selventa

RAHxZL6z0yQhbRjaiUYBNhG9W7SdAceq4jNO5mcjVnACo
has assertion: kin(p(PFH:"PRKC Family")) -> p(HGNC:PTK2,pmod(P,Y))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.450+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> p(HGNC:PTK2,pmod(P,Y))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10591686

5
value: PMA at 100 nmol/L strongly potentiated adhesion and tyrosine phosphorylation of p125(FAK) and p72(syk)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10591686

Selventa

RAE5nvuY aV97ukCOYHoglB5sncBOJ-SDKwWJq4DgYaYg
has assertion: p(MGI:Odc1) -> p(MGI:Ccnd1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.455+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Odc1) -> p(MGI:Ccnd1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10593650

4
value: Cyclin D1 was elevated to a smaller extent on overexpression of ornithine decarboxylase. Histone or Rb-associated kinase activities of cyclin complexes was elevated.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10593650

Selventa

RACRpg5m8m8q7WLAwdybPD95vwIGSQqeGW2rch7DjV1M0
has assertion: kin(p(MGI:Cdk2)) => p(MGI:Mybl2,pmod(P,T,267))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.461+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Cdk2)) => p(MGI:Mybl2,pmod(P,T,267))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10593981

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10593981

Selventa

RABD5IRKz99VLbcsvxnVK7NhLGLeYENOMd8MleXjtNI6c
has assertion: kin(p(MGI:Cdk2)) => p(MGI:Mybl2,pmod(P,T,408))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.462+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Cdk2)) => p(MGI:Mybl2,pmod(P,T,408))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10593981

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10593981

Selventa

RABAKqscgihMU4TJY-xOWOmSDKLQydLB2P8xo3C JWnAA
has assertion: bp(GO:"response to UV-B") -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.475+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to UV-B") -> bp(MESHPP:Apoptosis)
label: p(HGNC:NGF) -| (bp(GO:"response to UV-B") -> bp(MESHPP:Apoptosis))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10594731

4
value: nerve growth factor overexpressing keratinocytes were partially resistant to apoptosis induced by increasing doses of ultraviolet B
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10594731

Selventa

RAA36rCJn-jBNVLYhJyINsj7c2C ymy1M99Q2yCGLHZ5k
has assertion: bp(GO:"response to UV-B") -| r(HGNC:NGF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.478+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to UV-B") -| r(HGNC:NGF)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10594731

3
value: ultraviolet B radiation downregulated nerve growth factor mRNA and protein
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10594731

Selventa

RAFnIzzbnH70VB8NzG3vRsD5xxNeVRLsrMM79rZ7YGMtk
has assertion: gtp(p(HGNC:HRAS)) -> p(HGNC:BAD,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.487+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:HRAS)) -> p(HGNC:BAD,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10597268

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10597268

Selventa

RABkrMB TyKM2uIfQrnqYegr9GDPCTigvc0zYV2S-XUXk
has assertion: kin(p(HGNC:RAF1)) -| cat(p(HGNC:BAD))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.488+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:RAF1)) -| cat(p(HGNC:BAD))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10597268

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10597268

Selventa

RAHjOQVeXD6ngh6XvJhnOIgRUqh 5MMH-PIilox5wb3FE
has assertion: kin(p(PFR:"Prka Family")) -> p(RGD:Creb1,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.493+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFR:"Prka Family")) -> p(RGD:Creb1,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10600163

5
value: The present work provides evidence that cAMP, through PKA-mediated CREB phosphorylation, and phenobarbital induce ALA-S expression at the transcriptional level, while heme represses it.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10600163

Selventa

RABZX0AAeUfTvZj6k4z1414rurg0k0rES-MOoESrIDOtI
has assertion: cat(p(HGNC:RASGRF1)) -> gtp(p(HGNC:HRAS))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.500+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:RASGRF1)) -> gtp(p(HGNC:HRAS))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10601308

6
value: Site-directed mutagenesis replaced each of the serine residues within this region with alanine and demonstrated that serine 916 is a major site of in vivo phosphorylation of Ras-GRF1 in both COS-7 cells and NIH-3T3 fibroblasts.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10601308

Selventa

RAIvL5LqRP2ixP4zQsrE-v8 leLPArZdVddSYOPQ0lG7M
has assertion: a(SCHEM:Calcium) -> cat(p(HGNC:RASGRF1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.502+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> cat(p(HGNC:RASGRF1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10601308

4
value: The activity of Ras-GRF1 is regulated by increases in intracellular calcium and the release of Gbetagamma subunits from heterotrimeric G-proteins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10601308

Selventa

RABSPUqfsm3dGjR07NVoA-HaC8j62AbA40-NbTwNKJsrE
has assertion: a(SCHEM:"Concanavalin A") -> r(HGNC:IL4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.513+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Concanavalin A") -> r(HGNC:IL4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10607287

3
value: Interleukin 4 production by concanavalin A (Con A)-stimulated mesenteric lymph node cells (MLNC) was induced preferentially in infected +/+ mice.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10607287

Selventa

RACI3Z48Y7Id1lxFviMK5aHXh4JGGagIbKNZo5E XEW6w
has assertion: kin(p(HGNC:ATM)) => p(HGNC:LIG4,pmod(P,S,199))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.514+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:ATM)) => p(HGNC:LIG4,pmod(P,S,199))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10608806

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10608806

Selventa

RAOX3 teIPrlTuWyCSTr2yn CaXXAdRL1Xjh5H-BZI59s
has assertion: tscript(complex(NCM:"AP-1 Complex")) => r(MGI:Mmp13)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.526+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCM:"AP-1 Complex")) => r(MGI:Mmp13)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10613894

4
value: AP-1-dependent genes, such as collagenase (MMP-13) and stromelysin (MMP-3)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10613894

Selventa

RAJVSOAbRMcj8LKkePiXQbz3aSF-q4YuUWWsg3OGoiqSE
has assertion: cat(p(HGNC:SLC25A4)) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.529+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:SLC25A4)) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10613907

4
value: Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant, apoptosis-inducing genes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10613907

Selventa

RAIFqaHynMe2BHCS3UpgPOti4pI50w6sNOfZGNk8wiLPk
has assertion: cat(p(RGD:Xdh)) -> a(CHEBI:"reactive oxygen species")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.532+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Xdh)) -> a(CHEBI:"reactive oxygen species")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10615934

4
value: The increased expression of P-selectin appears to be triggered by a mechanism dependent on free radicals generated by xanthine oxidase released by the damaged pancreas.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10615934

Selventa

RAFTonJRk r-cdf9Nm8U3I9NfZeqt5k5Sft5oUhKgdr-I
has assertion: cat(p(HGNC:FAS)) -> a(CHEBI:ceramide)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.533+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:FAS)) -> a(CHEBI:ceramide)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10616904

4
value: All five cell lines did not express FADD by immunoblot analysis and were completely resistant to Fas-induced death. Complementation of the FADD mutant cell lines with wild-type FADD restored Fas-mediated apoptosis. Fas activation of caspase-2, caspase-3, caspase-7, and caspase-8 and the proteolytic cleavage of substrates such as BID, protein kinase Cdelta, and poly(ADP-ribose) polymerase were completely defective in the FADD mutant cell lines. In addition, Fas activation of the stress kinases p38 and c-Jun NH2 kinase and the generation of ceramide in response to Fas ligation were blocked in the FADD mutant cell lines
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10616904

Selventa

RAORrw0itKIHE0CZph7Hr19MWPwS3gJrnZ6p3jNwvdNzY
has assertion: tscript(complex(NCR:"Nfkb Complex")) -> tscript(p(RGD:Stat3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.544+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCR:"Nfkb Complex")) -> tscript(p(RGD:Stat3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10616907

5
value: We report that TNF induces DNA replication in growth-arrested LE6 cells and that its effect involves the activation of NFkappaB and STAT3 and an increase in c-myc and IL-6 mRNAs. We conclude that NFkappaB is an essential component of the TNF proliferative pathway and that TNF-induced changes in IL-6 mRNA, STAT3, and c-myc mRNA are dependent on NFkappaB activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10616907

Selventa

RAJXFFf3kUSl5MhIN0rHNUkWoSb8RnX1qlLNYTsOliRBw
has assertion: p(HGNC:CBL) -| kin(p(HGNC:SYK))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.551+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CBL) -| kin(p(HGNC:SYK))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10617633

5
value: The proto-oncogene product Cbl has emerged as a negative regulator of a number of protein-tyrosine kinases, including the ZAP-70/Syk tyrosine kinases that are critical for signaling in hematopoietic cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10617633

Selventa

RADyAftBxju6dIlb4xt65yydZL-tliMUcYSxw1piSBXFI
has assertion: a(SCHEM:"LY 294002") -| p(HGNC:RAC1,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.553+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"LY 294002") -| p(HGNC:RAC1,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10617634

3
value: Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10617634

Selventa

RAKODGPO9waORDNHOfw9CfXn8OmYp06FOyWd3O2De7TAg
has assertion: a(CHEBI:wortmannin) -> kin(p(HGNC:MAPK8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.560+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:wortmannin) -> kin(p(HGNC:MAPK8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10617634

4
value: Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10617634

Selventa

RAIaHtSYCNyOlCmZurFlNhzMqlyd1HCDOuVnmy-ESUjAg
has assertion: tscript(p(MGI:Trp53)) -> r(MGI:Psrc1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.571+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Trp53)) -> r(MGI:Psrc1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10618717

5
value: Actinomycin D, but not cycloheximide, inhibited the p53 dependent DDA3 induction, suggesting that the activation is through transcriptional regulation and does not require de novo protein synthesis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10618717

Selventa

RADOTp370jlOq kpPPWDM xUbu4ty5hAdoLzGL6kTFtXk
has assertion: complex(p(HGNC:PRKCZ),p(HGNC:RAF1),p(HGNC:YWHAQ)) -> (kin(p(HGNC:PRKCZ)) => p(HGNC:RAF1,pmod(P)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.582+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:PRKCZ),p(HGNC:RAF1),p(HGNC:YWHAQ)) -> (kin(p(HGNC:PRKCZ)) => p(HGNC:RAF1,pmod(P)))
label: kin(p(HGNC:PRKCZ)) => p(HGNC:RAF1,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10620507

10
value: Together, the results suggest that 14-3-3 binds both PKC-zeta (at phospho-Ser-186) and Raf-1 in a ternary complex. Phosphorylation of 14-3-3beta by PKC-zeta negatively regulated their physical association. 14-3-3beta with its putative PKC-zeta phosphorylation sites mutated enhanced co-precipitation between PKC-zeta and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-zeta weakens the complex in vivo. We conclude that 14-3-3 facilitates coupling of PKC-zeta to Raf-1 in an isotype-specific and phosphorylation-dependent manner. We suggest that 14-3-3 is a transient mediator of Raf-1 phosphorylation and activation by PKC-zeta.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10620507

Selventa

RANxv8Q-QnwfMvSboSkv8OYh3c1Xd1B0AuUtfSWGAWCvs
has assertion: kin(p(HGNC:PRKCZ)) => p(HGNC:YWHAQ,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.586+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PRKCZ)) => p(HGNC:YWHAQ,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10620507

5
value: Together, the results suggest that 14-3-3 binds both PKC-zeta (at phospho-Ser-186) and Raf-1 in a ternary complex. Phosphorylation of 14-3-3beta by PKC-zeta negatively regulated their physical association. 14-3-3beta with its putative PKC-zeta phosphorylation sites mutated enhanced co-precipitation between PKC-zeta and Raf-1, suggesting that phosphorylation of 14-3-3 by PKC-zeta weakens the complex in vivo. We conclude that 14-3-3 facilitates coupling of PKC-zeta to Raf-1 in an isotype-specific and phosphorylation-dependent manner. We suggest that 14-3-3 is a transient mediator of Raf-1 phosphorylation and activation by PKC-zeta.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10620507

Selventa

RAO2KiDBd8GTK056tWlU 9zVh4D-j9tS1b-Ol0F5HpWvk
has assertion: p(MGI:Cd40) -> p(MGI:Icam1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.600+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Cd40) -> p(MGI:Icam1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10623803

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10623803

Selventa

RAPCzTPRoIpHKQ5hxVTC-mzZ2rKMBwmc78ObHA38qvodA
has assertion: tscript(p(HGNC:"NKX2-5")) -> r(HGNC:IRX4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.606+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:"NKX2-5")) -> r(HGNC:IRX4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10625552

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10625552

Selventa

RAEko6wGYhFfpg0TclzluPDq2lpf POJy4Soj0-0DRpbg
has assertion: p(MGI:"Nkx2-5") -> r(MGI:Gata6)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.608+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:"Nkx2-5") -> r(MGI:Gata6)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10625555

4
value: These studies demonstrate that GATA6 is a direct target gene for Nkx2.5 in the developing heart and reveal a mutually reinforcing regulatory network of Nkx2.5 and GATA transcription factors during cardiogenesis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10625555

Selventa

RAMykYHq9qwI-oTsvFvUhmi7PS6MfXKPuqHQPyQ5zLADk
has assertion: bp(GO:"myoblast differentiation") -> r(HGNC:HSPB3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.615+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"myoblast differentiation") -> r(HGNC:HSPB3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10625651

3
value: The expressions of MKBP/HSPB2 and HSPB3 are induced during muscle differentiation under the control of MyoD, suggesting that the sHSP oligomer comprising MKBP/HSPB2 and HSPB3 represents an additional system closely related to muscle function.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10625651

Selventa

RAJDfwKUxOr-QECSTJq-S4j8nif Da7gJ0TGqh30TfePU
has assertion: tscript(p(HGNC:STAT3)) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.620+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:STAT3)) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10626893

4
value: The activation of STAT3 by the cytokine receptor gp130 is required for both the G1 to S cell cycle transition and antiapoptosis. #[JL] IL6ST is gp130
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10626893

Selventa

RANW O XhPsPHKYEeLoNULTNs6B9ADhyrg-lqSQmC-pp4
has assertion: p(HGNC:PIAS1) -> tscript(p(HGNC:AR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.623+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:PIAS1) -> tscript(p(HGNC:AR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10628744

5
value: In transient cotransfection assays using CV1 cells with full-length human AR and a mouse mammary tumor virus luciferase reporter vector, there was an androgen-dependent 3- to 5-fold greater increase in luciferase activity with PIAS1 over that obtained with an equal amount of control antisense cDNA or mutant PIAS1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10628744

Selventa

RAAzLuql5bfFHRCNCmqNPKlyteICcz0ikEh yBSXr37I4
has assertion: cat(p(RGD:Grm2)) -| a(CHEBI:melatonin)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.626+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Grm2)) -| a(CHEBI:melatonin)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10629750

4
value: binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10629750

Selventa

RAFxEeX3q-DreCgwLavo-XoNJUSv8LQF3F4rq0qvKBkws
has assertion: p(HGNC:TNF) -> p(HGNC:IL11)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.670+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> p(HGNC:IL11)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10632674

4
value: Treatment of osteoblasts cells with 100 U/ml of TNF-alpha for 72 hours results in enhanced basal IL-11 production.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10632674

Selventa

RAL2E390eRyFPal1zOHGiNnGtoDAGUTu4ChLruJB1VSk0
has assertion: a(SCHEM:"Low Density Lipoprotein") -> r(HGNC:UBE2K)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.681+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Low Density Lipoprotein") -> r(HGNC:UBE2K)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10634809

3
value: we isolated the genes specifically induced by agLDL by using a subtraction-based cloning strategy. One of the cloned genes, termed low density lipoprotein (LDL)-inducible gene (LIG), encodes a human homologue of bovine ubiquitin-conjugating enzyme E2-25K. Although LIG mRNA was ubiquitously expressed among human tissues, including hematopoietic cells, the abundance of transcripts was markedly increased by agLDL treatment in activated monocytes.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10634809

Selventa

RAKTTLiwzXBSgzWuc mRxeJvIeruRvdRqaSY-dpF7O-r8
has assertion: kin(p(MGI:Fyn)) -> gtp(p(PFM:"Ras Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.692+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Fyn)) -> gtp(p(PFM:"Ras Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10636870

6
value: In Fyn-/- fibroblasts, activation of Ras by H(2)O(2) was significantly attenuated.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10636870

Selventa

RAA-FITYmtodcM5E1R1YwibM70T9FqKMBiNm5vdPmY9tg
has assertion: phos(complex(NCM:"Calcineurin Complex")) -| p(MGI:Nfatc4,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.695+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(complex(NCM:"Calcineurin Complex")) -| p(MGI:Nfatc4,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10636885

4
value: Activation of the Adss1 gene involves the calcineurin-mediated dephosphorylation of NFAT3, allowing its translocation to the nucleus, where it can directly participate in Adss1 gene activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10636885

Selventa

RAMWp6fyXxZxBHMBhSC1b2PWVB-z6TEfE1c2U6YsaqBk8
has assertion: phos(complex(NCM:"Calcineurin Complex")) -> tscript(p(MGI:Nfatc4))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.698+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(complex(NCM:"Calcineurin Complex")) -> tscript(p(MGI:Nfatc4))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10636885

5
value: Activation of the Adss1 gene involves the calcineurin-mediated dephosphorylation of NFAT3, allowing its translocation to the nucleus, where it can directly participate in Adss1 gene activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10636885

Selventa

RAFkrbq52WRceZWPUzU8 LjNQnwRQpc36DswVjjCcl0k4
has assertion: tscript(p(HGNC:MEF2C)) -> r(HGNC:ADSSL1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.699+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:MEF2C)) -> r(HGNC:ADSSL1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10636885

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10636885

Selventa

RAFkQvzVbju 4E2boBTfPV345cxbpxqVbaY3sdFeA ydo
has assertion: cat(p(HGNC:GLRX3)) -| tscript(p(HGNC:FOS))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.701+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:GLRX3)) -| tscript(p(HGNC:FOS))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10636891

6
value: overexpression of full-length PICOT (but not its N- or C-terminal fragments) in T cells inhibited the activation of c-Jun N-terminal kinase and the transcription factors AP-1 or NF-kappaB.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10636891

Selventa

RAGDHg1sWyWl-rekpqzNEINmPftLK9dsEedcTxTEWB5ck
has assertion: p(HGNC:CCL3) -> p(HGNC:FLT3LG)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.710+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CCL3) -> p(HGNC:FLT3LG)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10637491

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10637491

Selventa

RABQ0rwADH9zffiq823SlihvWaR3thaGpmOoII 5I8TeU
has assertion: p(HGNC:TGFB1) -> p(HGNC:FLT3LG)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.713+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TGFB1) -> p(HGNC:FLT3LG)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10637491

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10637491

Selventa

RAIemSYaWT2-h72050sKCo-sSDE cshd7Yu5vFbKc4Z5I
has assertion: a(CHEBI:"nitric oxide") -> a(SCHEM:"Cyclic GMP")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.720+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> a(SCHEM:"Cyclic GMP")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10639014

2
value: 1) in endothelial cells PDE4 inhibition may up-regulate basal production of NO, this effect being potentiated by PDE2 inhibition; 2) in smooth muscle cGMP produced by NO inhibits PDE3 and increases cAMP level
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10639014

Selventa

RABnmEf4yB8t5AM8Roa2yRPalArLuBK6roFcplh2lcynQ
has assertion: cat(p(PFH:"PDE4 Family")) -| a(CHEBI:"nitric oxide")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.722+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(PFH:"PDE4 Family")) -| a(CHEBI:"nitric oxide")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10639014

4
value: 1) in endothelial cells PDE4 inhibition may up-regulate basal production of NO, this effect being potentiated by PDE2 inhibition; 2) in smooth muscle cGMP produced by NO inhibits PDE3 and increases cAMP level
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10639014

Selventa

RAJ4uPMWrlHN2SpeDoJKFPScWihwZBvu5rMz3bQV23pDk
has assertion: cat(p(HGNC:PDE3A)) -| kin(p(HGNC:PRKG1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.728+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:PDE3A)) -| kin(p(HGNC:PRKG1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10639014

6
value: 3) protein kinase G mediates the relaxing effects of PDE3 or PDE4 inhibition
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10639014

Selventa

RABn0EtXFtDPanL7sjv0ry18NG0v4y3sYkYC3lmayu6dc
has assertion: a(CHEBI:"nitric oxide") -| cat(p(PFH:"PDE4 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.731+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -| cat(p(PFH:"PDE4 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10639014

4
value: 4) DNIC inhibits non competitively PDE4B indicating a direct effect of NO on PDE4 which could explain an additive vasodilatory effect of NO
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10639014

Selventa

RAI9WIJqrZ64mcPVp7l8ZD1nX7d6d0UpzPZOBQ8AgWUsI
has assertion: tscript(p(HGNC:NCOR2)) -> cat(p(PFH:"HDAC Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.748+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:NCOR2)) -> cat(p(PFH:"HDAC Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10640276

6
value: The transcriptional corepressor SMRT functions by mediating the repressive effect of transcription factors involved in diverse signaling pathways. Taken together, our results provide the first evidence that SMRT-mediated repression is promoted by class I and class II histone deacetylases and that SMRT can recruit class II histone deacetylases
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10640276

Selventa

RACdQC8gE8snkuAPHot8lNTH5X5VnqJMwlTCRYX vz5wY
has assertion: p(MGI:Neurog2) -> r(MGI:Nhlh1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.763+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Neurog2) -> r(MGI:Nhlh1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10640277

4
value: Reduction in the expression levels of Nscl1 (dorsal -specific neuronal marker) was observed in the dorsal and medial telencephalic preplate of Ngn2 mutant at E12.5 as compared to wild-type. These results demonstrate that Ngn2 plays an important role in the upregulation of dorsal postmitotic markers leading to dorsal neuron specification.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10640277

Selventa

RAHDiUWjhKBQ6jawTsVSsCIX2gANELU8vHAfPwGe6QtG0
has assertion: p(PFH:"TGFB Family") -| r(HGNC:FAS)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.770+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFH:"TGFB Family") -| r(HGNC:FAS)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10640741

4
value: The cytokine TGF-beta inhibits basal expression of Fas as well as cytokine-mediated Fas expression by microglia
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10640741

Selventa

RAKp0ySIZwvbunDD1wCvxwR6iz2uBlbtg gNF6m1i85A8
has assertion: cat(p(EGID:81638)) -> bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.775+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(EGID:81638)) -> bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10642310

4
value: Ang II induces integrin and alpha-actinin expression in cardiac fibroblasts that is associated with adhesion and left ventricular hypertrophy and blocked through inhibition of the AT(1) receptor.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10642310

Selventa

RAANty kQ6JvD2xHbyQuy0QdpJyjm62XJEgNyKB-V-B68
has assertion: path(SDIS:"mechanical stress") -> kin(p(HGNC:PTK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.788+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"mechanical stress") -> kin(p(HGNC:PTK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10642399

4
value: FAK is activated by the mechanical stretch of muscle (28, 57, 62). Interestingly, stretch activation of FAK and paxillin in smooth muscle is not dependent on tension development but only sensitive to muscle length changes (62).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10642399

Selventa

RAMdv8AQfpMtV-pvNnPG0H44ZmD8cAyNXm-7qxreyu53E
has assertion: path(SDIS:"mechanical stress") -> kin(p(HGNC:PTK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.791+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"mechanical stress") -> kin(p(HGNC:PTK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10642399

4
value: Stretch has been shown to activate FAK in cardiac myocytes (57), smooth muscle (62), and skeletal muscle (28).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10642399

Selventa

RAD5sRVztUW8rBom6cE2hxoCkh1D0qfqPiOID8scDuXpM
has assertion: kin(p(PFH:"PRKA Family")) -> p(HGNC:STK11,pmod(P,S,431))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.797+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKA Family")) -> p(HGNC:STK11,pmod(P,S,431))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10642527

5
value: The predicted LKB1 protein sequence terminates with a conserved prenylation motif (Cys(433)-Lys-Gln-Gln(436)) directly downstream from a consensus cAMP-dependent protein kinase (PKA) phosphorylation site (Arg(428)-Arg-Leu-Ser(431)).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10642527

Selventa

RAMwgUTmcr4FvkNXxwxff4s6TmlP7kYINuXWZhM9nSHDM
has assertion: complex(p(HGNC:OMD),p(HGNC:ITGAV),p(HGNC:ITGB3)) -> bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.805+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:OMD),p(HGNC:ITGAV),p(HGNC:ITGB3)) -> bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10644720

6
value: # Ariadne: It has been demonstrated that osteoadherin can mediate cell attachment via binding by alpha v eta 3 integrin in vitro ( 45 ). [Regulation]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10644720

Selventa

RANO7LQJzZMH3EKlIULEjdEFz63clzfF-52ne2gE1uTB0
has assertion: kin(p(MGI:Fgfr2)) -> kin(p(MGI:Mapk1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.816+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Fgfr2)) -> kin(p(MGI:Mapk1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10646118

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10646118

Selventa

RAHHLbQ3AFHKGmlheywNs4q2pMmtQ0-Fg82IsqHUtEBdI
has assertion: path(SDIS:"mechanical stress") -> r(MGI:Hdgf)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.821+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"mechanical stress") -> r(MGI:Hdgf)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10646787

3
value: Sequencing identified 4 differentially expressed genes enhanced by tracheal ligation: hepatoma-derived growth factor (HDGF), ribosomal protein S24, stathmin, and parathyroid hormone (PTH).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10646787

Selventa

RAKVgnG2Cu96l26sBu6OLvDoyEk3fMoU8Vgcwoo0YA1JI
has assertion: path(SDIS:"mechanical stress") -> r(MGI:Rps24)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.824+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"mechanical stress") -> r(MGI:Rps24)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10646787

3
value: Sequencing identified 4 differentially expressed genes enhanced by tracheal ligation: hepatoma-derived growth factor (HDGF), ribosomal protein S24, stathmin, and parathyroid hormone (PTH).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10646787

Selventa

RAFy9tUxETFpKC1Sz-MS5OBC-egBUuaDw3Jt6B Gt7LaU
has assertion: path(SDIS:"mechanical stress") -> r(MGI:Stmn1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.825+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"mechanical stress") -> r(MGI:Stmn1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10646787

3
value: Sequencing identified 4 differentially expressed genes enhanced by tracheal ligation: hepatoma-derived growth factor (HDGF), ribosomal protein S24, stathmin, and parathyroid hormone (PTH).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10646787

Selventa

RAMRyQejQlJhPKqCVY2ms8Vb4kWuSd-yOn-Om1-3LLJIA
has assertion: phos(p(HGNC:PTEN)) -| complex(p(HGNC:EGF),p(HGNC:EGFR),p(HGNC:GAB1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.835+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(HGNC:PTEN)) -| complex(p(HGNC:EGF),p(HGNC:EGFR),p(HGNC:GAB1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10648629

8
value: expression of the gene for the lipid phosphatase PTEN, which dephosphorylates PtdIns(3,4, 5)P3, inhibits EGF signaling and translocation of Gab1 to the plasma membrane.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10648629

Selventa

RAEncx mWVzPcx rITSDMaV2jLosromi5E64 anGGFJSI
has assertion: kin(p(MGI:Ern1)) -> kin(p(MGI:Mapk8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.837+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Ern1)) -> kin(p(MGI:Mapk8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10650002

6
value: ER stress led to a twofold increase in JNK activity in wild-type fibroblasts, whereas in the IRE1alpha-^sup 1^- fibroblasts JNK activity was decreased by ER stress (Fig. 2B).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10650002

Selventa

RAALbnQZteVUDAuJKg5YnqFtjfiOM6tqEQCB8VuYtqE9o
has assertion: cat(p(HGNC:HSD11B1)) -> deg(a(SCHEM:Hydrocortisone))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.840+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:HSD11B1)) -> deg(a(SCHEM:Hydrocortisone))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10650936

5
value: Observations in obese men suggest enhanced inactivation of cortisol by 5alpha-reductase and altered reactivation of cortisone to cortisol by 11betahydroxysteroid dehydrogenase type 1 (11betaHSD1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10650936

Selventa

RAIY4BnV62O0dSR2-yBXrB 6OxjdRwj2yKxBju25JRxkg
has assertion: cat(p(HGNC:SRD5A1)) -| a(CHEBI:glucocorticoid)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.843+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:SRD5A1)) -| a(CHEBI:glucocorticoid)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10650936

4
value: We conclude that greater inactivation of glucocorticoids by 5alpha-reductase in liver and 11betaHSD2 in kidney combined with impaired reactivation of glucocorticoids by 11betaHSD1 in liver may increase the MCR of glucocorticoids and decrease local glucocorticoid concentrations at these sites.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10650936

Selventa

RAPYYVgicHCCw2wTAa3ZyOmbvA0s0WbZ3nNJ3xmFmV9bo
has assertion: cat(p(HGNC:HSD11B1)) -> tscript(p(HGNC:NR3C1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.844+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:HSD11B1)) -> tscript(p(HGNC:NR3C1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10650936

6
value: enhanced 11betaHSD1 in omental adipose tissue may increase local glucocorticoid receptor activation and promote obesity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10650936

Selventa

RAKLR9Vsad6c6q91g3kbLXw8309ByJeMbpu8rOoT-WjTs
has assertion: tscript(p(EGID:5925)) -> r(HGNC:HPGD)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.848+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(EGID:5925)) -> r(HGNC:HPGD)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10650939

5
value: In myometrial SMC, both isoforms of the progesterone receptor, PR-B and PR-A, caused a ligand-dependent activation of PGDH-2368/luc3. Transcriptional activity of PR-B was further enhanced by the addition of 8-bromo-cAMP
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10650939

Selventa

RAH0q nwyA-fsxMZ-A02u2A- X svIPKHh1x3eN1IIxSk
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:HPGD)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.849+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:HPGD)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10650939

3
value: PGDH promoter was strongly induced by phorbol ester
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10650939

Selventa

RABHvaO plx2nhh12bD2rhDv8AYGtpi9FdqjtvsWrRQ9A
has assertion: a(SCHEM:Tretinoin) -> r(HGNC:TNC)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.854+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Tretinoin) -> r(HGNC:TNC)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10651229

3
value: TR and the other two [13-cis-retinoic acid/isotretinoin and all trans-retinoic acid] retinoids dose-dependently induced tenascin-C expression in the fibroblasts.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10651229

Selventa

RAItbe7oY7b1UKZKLHwf39voMj7hNx3cgtX8zoboUUClw
has assertion: kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| r(HGNC:ESR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.870+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(complex(NCH:"p85/p110 PI3Kinase Complex")) -| r(HGNC:ESR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10653980

4
value: Protein kinase A and phosphatidylinositol 3-kinase inhibitors blocked the IGF-I effects on ER-alpha expression and activity, suggesting that these kinases may be involved in the cross-talk between the IGF-I and ER-alpha pathways.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10653980

Selventa

RAIYbMjnFN0vU 7YuVDQ3k7XHX47BFc5H25UbYXIuw wo
has assertion: complex(p(HGNC:PTPN11),p(HGNC:EPHA2)) => phos(p(HGNC:PTPN11))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.878+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:PTPN11),p(HGNC:EPHA2)) => phos(p(HGNC:PTPN11))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10655584

7
value: complex
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10655584

Selventa

RAOSSdQNKUrSdIWuixLur-6z4wOyaYKE8CG4Q-Um C Jw
has assertion: tscript(p(HGNC:MYBL2)) -> bp(GO:"DNA replication")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.882+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:MYBL2)) -> bp(GO:"DNA replication")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10656684

4
value: B-Myb is a transcription factor belonging to the myb family, whose activity has been associated with augmented DNA synthesis and cell cycle progression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10656684

Selventa

RAGMbb4b60WER38K25KUcYbV8IUplVLT-20q7uV jh8k
has assertion: complex(p(HGNC:CDK9),p(HGNC:CCNT1)) -| (complex(p(HGNC:CDK9),p(HGNC:MYBL2)) -| tscript(p(HGNC:MYBL2)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.887+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:CDK9),p(HGNC:CCNT1)) -| (complex(p(HGNC:CDK9),p(HGNC:MYBL2)) -| tscript(p(HGNC:MYBL2)))
label: complex(p(HGNC:CDK9),p(HGNC:MYBL2)) -| tscript(p(HGNC:MYBL2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10656684

11
value: Cyclin T1 restores B-Myb transactivating activity when co-transfected along with CDK9, suggesting that the down-regulatory effect observed on B-Myb is specifically due to CDK9 alone.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10656684

Selventa

RAA0nXXT47Xu61I2-mzgHuatfqps9EqT8txF 2EDWCUuw
has assertion: p(MGI:Mbp) -> r(MGI:Ccr2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.897+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Mbp) -> r(MGI:Ccr2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10657666

4
value: At the time of disease onset (day 7), a 2 to 5-fold increase in expression of CCR2 was observed. In GL3-treated mice, reduced levels of CCR2 was observed on day 6 and remained lower than in the EAE controls on day 7.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10657666

Selventa

RAMhBubvuzwSZZ24x-Ia3jwL9I7LGAWJKNlgnNa-wC-fI
has assertion: bp(GO:"muscle contraction") -> r(HGNC:GYG1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.909+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"muscle contraction") -> r(HGNC:GYG1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10658052

3
value: For the first time, we report that a single bout of exercise is sufficient to cause upregulation of GLUT-4 and glycogenin gene expression in human skeletal muscle.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10658052

Selventa

RAEzwNhUZ06XNCyGE8 pMQetRaqzgiixvoFiq6z961OVc
has assertion: a(SCHEM:Sirolimus) -| (a(SCHEM:Sirolimus) -| p(HGNC:STAT3,pmod(P,S,727)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.916+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Sirolimus) -| (a(SCHEM:Sirolimus) -| p(HGNC:STAT3,pmod(P,S,727)))
label: a(SCHEM:Sirolimus) -| p(HGNC:STAT3,pmod(P,S,727))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10660304

4
value: We found that CNTF-induced phosphorylation of Ser727 was inhibited by the mTOR inhibitor rapamycin, but not by inhibitors of MAPK and protein kinase C (PKC) activation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10660304

Selventa

RAKiTPSVE06SrU9dBoFLQUvv5aeOcxs5yK7GVLVG9xTl0
has assertion: p(HGNC:NCOA1,pmod(P,S)) -> p(HGNC:NCOA1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.922+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NCOA1,pmod(P,S)) -> p(HGNC:NCOA1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10660621

4
value: All the sites contained consensus sequences for the serine/threonine-proline-directed family of protein kinases, and two sites (serine 395 and threonine 1179) contained a perfect consensus sequence for the mitogen-activated protein kinase family (Erk-1 and Erk-2). % Erk-2 phosphorylated threonine 1179 and serine 1185 (and to a lesser extent, serine 395) in vitro,
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10660621

Selventa

RAGe2kSrK1gI2DweTXtrbLy2UODV-HWA2z3zyHYd Gmz4
has assertion: kin(p(HGNC:MAPK1)) => p(HGNC:NCOA1,pmod(P,S,395))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.930+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) => p(HGNC:NCOA1,pmod(P,S,395))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10660621

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10660621

Selventa

RAKbWf 8sKw1XUsZcRQNXFbFRtaVwIgGZP3J 63iJBKUM
has assertion: p(MGI:Vegfb) -> bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.939+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Vegfb) -> bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10666423

3
value: Despite appearing overtly normal, Vegfb(-/-) hearts are reduced in size and display vascular dysfunction after coronary occlusion and impaired recovery from experimentally induced myocardial ischemia.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10666423

Selventa

RAErdFr8Nvs7SoTr-lXcFKXLYIs6BBwyNZFQ0kuIas2EU
has assertion: cat(p(HGNC:PTGDS)) -> a(CHEBI:"prostaglandin D2")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.941+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:PTGDS)) -> a(CHEBI:"prostaglandin D2")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10668396

4
value: Prostaglandin (PG) D synthase catalyzes the isomerization of PGH2, a common precursor of various prostanoids, to produce PGD2
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10668396

Selventa

RAP4GwM1tTWj4pp9wtPkoUanI1pIk-dHSF-UK41oW6Iws
has assertion: cat(p(HGNC:MSR1)) -> bp(GO:"cell adhesion")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.946+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:MSR1)) -> bp(GO:"cell adhesion")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10669623

4
value: SRA has been shown to be important in the inflammatory response in host defense, cellular activation, adhesion, and cell-cell interaction. Given the importance of these processes in atherogenesis, these latter functions may prove to make the SRA a multifunctional player in the atherosclerotic process
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10669623

Selventa

RANU7IdWGoo8gb HStUguV r3j7IjHA78QW668kwpDgRw
has assertion: p(RGD:Tnf) -> p(RGD:Mapk1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.948+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Tnf) -> p(RGD:Mapk1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10669634

4
value: TNF-alpha induced rapid biphasic increase in ERK1/2 phosphorylation which was detected as early as 2 minutes after addition of TNF-alpha and reached a maximum after 15 mins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10669634

Selventa

RALLVHYIBvelR3O9AEMm7ZPLtAbiuYR b98CeE2Zw8OF0
has assertion: p(RGD:Tnf) -> p(RGD:Mapk1,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.949+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Tnf) -> p(RGD:Mapk1,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10669634

4
value: TNF-alpha induced rapid biphasic increase in ERK1/2 phosphorylation which was detected as early as 2 minutes after addition of TNF-alpha and reached a maximum after 15 mins.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10669634

Selventa

RAI8MtQz4UB8xSATeBu6MMEA6gwT5NqX5ZTSjpISJYirA
has assertion: gtp(p(HGNC:RAC1)) -> tloc(p(HGNC:TWF1),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.959+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

gtp(p(HGNC:RAC1)) -> tloc(p(HGNC:TWF1),GOCCACC:"GO:0005737",GOCCACC:"GO:0005634")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10669753

6
value: Furthermore, expression of the activated Rac1(V12) in NIH 3T3 cells leads to an increased A6/twinfilin localization to nucleus and cell cortex, whereas a dominant negative form of Rac1(V12,N17) induces A6/twinfilin localization to cytoplasm.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10669753

Selventa

RAM3lk1Gim7shGdGdSas Tj4Lgfh4cY8m8Waw5e4h0BhE
has assertion: kin(p(MGI:Prkg1)) => complex(p(MGI:Gkap1),p(MGI:Prkg1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.966+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Prkg1)) => complex(p(MGI:Gkap1),p(MGI:Prkg1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10671526

7
value: Although both cGK-Ialpha and -Ibeta, but not cAMP-dependent protein kinase, phosphorylated GKAP42 in vitro, GKAP42 was a good substrate only for cGK-Ialpha in intact cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10671526

Selventa

RAABoZfYErds1CM2q3QXA6tPv8u0HVleiJ0FdtXmqY 5M
has assertion: complex(p(HGNC:JUN),g(HGNC:LDLR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.971+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:JUN),g(HGNC:LDLR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10671569

3
value: Three DNA-protein complexes (C1, C3 and C4) were detected in control extracts and 4 complexes (C1, C2, C3 and C4) were detected in oncostatin M (OM)-treated nuclear extracts using a P32-labeled oligonucleotide probe (TATA1+2) containing LDLR promoter sequence -25 to +5. EMSA studies demonstrated that the C1 complex was completely supershifted by anti-c-Jun antibodies but none of these antibodies affected the C2 complex. The data suggest that the C1 complex may be a heterodimer of ATF and c-Jun; c-Jun is not present in the C2 complex. Additional gel shift assays using control extract showed a weaker supershift band with anti-c-Jun antibodies compared to the OM-treated extract, suggesting that OM stimulation may increase the c-Jun DNA-binding activity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10671569

Selventa

RANHU9Hnp1J KomR0Bwai5CeAGofv-WjBcLlJgvqyjLBs
has assertion: complex(p(HGNC:RBMS1),p(HGNC:MYC),p(HGNC:MAX)) -| tscript(p(HGNC:MYC))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.972+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:RBMS1),p(HGNC:MYC),p(HGNC:MAX)) -| tscript(p(HGNC:MYC))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10672043

8
value: ^ MSSP, c-Myc and Max formed a ternary complex in vivo, although MSSP did not directly associate with Max.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10672043

Selventa

RAIYfFg kNo9ei1FDmR5lur9WAszMNBBfvXdUhnqqpQp8
has assertion: p(HGNC:IL6) -> bp(GO:"lymphocyte differentiation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.974+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL6) -> bp(GO:"lymphocyte differentiation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10673382

3
value: Cultures of the myeloid leukemia cell line M1 were induced to terminally differentiate by treatment with interleukin-6 (IL-6).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10673382

Selventa

RAICrGMdHsGyQQ QybGk9z8a4VNcv2o9RafN6PdxlIHz4
has assertion: p(HGNC:CAMK4) -> tscript(p(HGNC:RORC))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.982+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CAMK4) -> tscript(p(HGNC:RORC))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10675338

5
value: # Ariadne: Other orphan receptors including RORalpha2, RORgamma and COUP-TFI are also potentiated by CaMKIV. [Regulation]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10675338

Selventa

RAJ3E9Q1kUHDMcaAiCP-PmgXlIlr1omVUSB MXq1xnXwI
has assertion: a(SCHEM:Calcium) -> tscript(p(HGNC:RORA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.984+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Calcium) -> tscript(p(HGNC:RORA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10675338

4
value: Retinoid-related receptor alpha (RORalpha) is an orphan nuclear receptor that constitutively activates transcription from its cognate response element. We show that RORalpha is Ca(2+ )responsive, and a Ca(2+)/calmodulin-independent form of Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) potentiates RORalpha-dependent transcription 20- to 30-fold.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10675338

Selventa

RAP5bK1c4RovMBdUVu4WH4FgU ceYvxdeTpaa1r112Nl4
has assertion: a(CHEBI:paclitaxel) -> p(HGNC:BCL2,pmod(P,S,87))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.989+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:paclitaxel) -> p(HGNC:BCL2,pmod(P,S,87))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10675481

3
value: we have previously mapped taxol induced phosphorylation sites to be Ser-70 and 87 residues of Bcl2 protein
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10675481

Selventa

RADarogbOjVq4hZOrhkunxyqsIAr6ySfrmeG0xqOzvHb0
has assertion: a(CHEBI:troglitazone) -> r(HGNC:DRG1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:49.992+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:troglitazone) -> r(HGNC:DRG1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10676663

3
value: Moreover, the expression of Drg-1 is controlled by several known cell differentiation reagents, such as ligands of peroxisome proliferator-activated receptor gamma (troglitazone and BRL46593) and of retinoid X receptor (LG268), and histone deacetylase inhibitors (trichostatin A, suberoylanilide hydroxamic acid, and tributyrin).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10676663

Selventa

RAHmDdQui80Z1c4MadogyKEfo5y91xjIM1sX26E331ISY
has assertion: kin(p(MGI:Mapk3)) => p(MGI:Bcl2,pmod(P,S,70))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.001+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(MGI:Mapk3)) => p(MGI:Bcl2,pmod(P,S,70))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10677502

5
value: p44MAPK/extracellular signal-regulated kinase 1 (ERK1) and p42 MAPK/ERK2 are activated by IL-3, colocalize with mitochondrial Bcl2, and can directly phosphorylate Bcl2 on Ser-70 in a stauro-resistant manner both in vitro and in vivo
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10677502

Selventa

RAHKZFhibIBZHqbwb5znoJWbrMDBNnZ UpGZejhor 4Bc
has assertion: p(EGID:183) -> a(CHEBI:aldosterone)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.002+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:183) -> a(CHEBI:aldosterone)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10678544

3
value: Adrenomedullin inhibits angiotensin II stimulated aldosterone production in vitro and in vivo in experimental animals. Adrenomedullin selectively inhibits angiotensin II-stimulated aldosterone production.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10678544

Selventa

RAN-N6W X7L prW0d1U5UjERS56ONWgJ-zkpYAI5P0 Yk
has assertion: a(SCHEM:Dinoprostone) -| bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.011+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Dinoprostone) -| bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10678579

2
value: COX-2 synthesizes prostaglandin E2 (PGE2) which stimulates bcl-2 and inhibits apoptosis, and induces interleukin-6 (IL-6) which enhances haptoglobin synthesis. PGE2 is associated with tumor metastases, IL-6 with cancer cell invasion, and haptoglobin with implantation and angiogenesis
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10678579

Selventa

RAD wXP9cNaD6W2olBPsfiNFpIBUaFQ-f vEzBU Ilp1k
has assertion: bp(GO:"response to oxidative stress") -> r(HGNC:PTGS2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.019+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"response to oxidative stress") -> r(HGNC:PTGS2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10678579

3
value: Dexamethasone, antioxidants, and tumor-suppressor protein p53 suppress COX-2 expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10678579

Selventa

RAIegpP-gKyvroRMXzEubZ7VJpS6xtI0IieCRug1eCNWI
has assertion: p(HGNC:IL1B) -> p(HGNC:IL18)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.023+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL1B) -> p(HGNC:IL18)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10679109

4
value: % Jubilant: IL-1beta upon inducing its own production in an autocrine/paracrine fashion, in turn, up-regulates IL-18 production at the protein level.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10679109

Selventa

RAELLCzRLopWNdCBH hEegJ-mo8cvFT3sXnBDdmn4pzvs
has assertion: p(MGI:Ifngr1) -> p(MGI:Nos2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.060+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ifngr1) -> p(MGI:Nos2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10679118

4
value: The Nos2 immunoreactivity in the CNS of IFN-gamma -/- mice or IFN-gamma-receptor-/- mice with EAE was barely detectable, whereas in SJL/J mice infiltrates were strongly stained for Nos2 during EAE.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10679118

Selventa

RAKP8hxl gkcSq A9LBe2FdlP4a06vlFjUVIb4-NkcpR8
has assertion: p(HGNC:EGF) -> complex(p(HGNC:CBL),p(HGNC:SH3KBP1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.063+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:EGF) -> complex(p(HGNC:CBL),p(HGNC:SH3KBP1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10679202

6
value: The CIN85-c-Cbl association was enhanced shortly after stimulation of 293 cells with epidermal growth factor (EGF) and gradually diminished to a basal level, which correlated with a tyrosine phosphorylation level of c-Cbl.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10679202

Selventa

RAGcikSqb wslAdKbzL5sELPIOUyTq2NfM JCe1KEd7vs
has assertion: cat(p(MGI:Prdx5)) -| (tscript(p(MGI:Trp53)) -> bp(MESHPP:Apoptosis))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.064+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(MGI:Prdx5)) -| (tscript(p(MGI:Trp53)) -> bp(MESHPP:Apoptosis))
label: tscript(p(MGI:Trp53)) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10679306

7
value: Pubmed:gene: Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10679306

Selventa

RAIK5ABfUCaBBeIlHDqOciPjhUdbU31yCKdoGx0z tZ c
has assertion: kin(p(RGD:Prkcz)) -> (p(RGD:Fgf2) -> p(RGD:Gja1,pmod(P)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.074+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(RGD:Prkcz)) -> (p(RGD:Fgf2) -> p(RGD:Gja1,pmod(P)))
label: p(RGD:Fgf2) -> p(RGD:Gja1,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10679481

7
value: We conclude that PKC mediates the FGF-2-induced effects on cardiac GJs and that PKCepsilon likely interacts with and phosphorylates cardiac Cx43 at sites of intercellular contact.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10679481

Selventa

RAEJ1aZE63bmrUeGf1xcTuxqXyNv3RMp2nHAvLwW MIxc
has assertion: a(SCHEM:"cyclic AMP") -| r(RGD:Col1a1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.077+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"cyclic AMP") -| r(RGD:Col1a1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10679825

3
value: After 48 h of culture, parathyroid hormone, forskolin, dibutyryl cAMP, 8-bromo cAMP, and phorbol myristate acetate inhibited transgene activity, while the calcium ionophore ionomycin had no effect. These data show that the inhibitory effect of parathyroid hormone on Col1a1 expression in mouse calvariae is mediated mainly by the cAMP signaling pathway.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10679825

Selventa

RAGvijQ3nFbayjCl8iXfuNROia1g-G5Qu9JUS8rBVgIK4
has assertion: complex(p(HGNC:IL12A),p(HGNC:IL12B)) -| (p(HGNC:IL1B) -> a(SCHEM:Dinoprostone))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.081+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:IL12A),p(HGNC:IL12B)) -| (p(HGNC:IL1B) -> a(SCHEM:Dinoprostone))
label: p(HGNC:IL1B) -> a(SCHEM:Dinoprostone)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10681439

7
value: Consistent with these observations, IL-12, a known inducer of IFN-gamma, augmented IL-1beta-induced IFN-gamma but suppressed IL-1beta-induced PGE(2) by 75%.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10681439

Selventa

RADmCZ tVfiLbRpZVDyWmJOEglY0kmFLQ08WtLsaORMeY
has assertion: complex(p(HGNC:IL12A),p(HGNC:IL12B)) -> p(HGNC:IFNG)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.082+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:IL12A),p(HGNC:IL12B)) -> p(HGNC:IFNG)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10681439

6
value: Consistent with these observations, IL-12, a known inducer of IFN-gamma, augmented IL-1beta-induced IFN-gamma but suppressed IL-1beta-induced PGE(2) by 75%.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10681439

Selventa

RAHis3Pf71B09qTS0P2tO8DflKTAUD iC7D-0ziMLgw7I
has assertion: p(HGNC:IL1B) -> a(SCHEM:Dinoprostone)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.086+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL1B) -> a(SCHEM:Dinoprostone)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10681439

3
value: In the same cultures, IL-1beta induced a 12-fold increase in PGE(2). Although IL-1beta-induced IL-8 synthesis was augmented 3-fold by IL-18, IL-18 suppressed IL-1beta-induced PGE(2) production by 40%.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10681439

Selventa

RAPHQ4dyU9KalAfifMhFcsPK1GGn lL xxTyBnbHf3r-Q
has assertion: p(HGNC:IL18) -> p(HGNC:IFNG)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.090+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL18) -> p(HGNC:IFNG)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10681439

4
value: The suppressive effect of IL-18 on PGE(2) production was mediated by interferon (IFN)-gamma because anti-human IFN-gamma-antibody prevented IL-18-induced reduction in PGE(2).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10681439

Selventa

RABEGIstUKhGp03zVKGXVblrqUdA9fjhnMmGNpxoXa51g
has assertion: kin(p(HGNC:PRKG1)) => p(HGNC:CRIP2,pmod(P,S,104))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.094+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PRKG1)) => p(HGNC:CRIP2,pmod(P,S,104))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10681529

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10681529

Selventa

RAO8qBichhM270xandxq7 LSgbcz6beZWt7403ohHYXJ0
has assertion: p(RGD:Ngf) -> gtp(p(PFR:"Ras Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.111+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ngf) -> gtp(p(PFR:"Ras Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10688641

5
value: 5PC-12 cells stimulated with 100 ng per ml NGF showed increase in Ras activation after 5 minutes, which was maintained after 45 minutes of NGF stimulation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10688641

Selventa

RANLQOCCm5nwHIoUddnyhzb9 dJ91kkvRqdAl94qFp2Zc
has assertion: a(CHEBI:"reactive oxygen species") -> cat(p(HGNC:ALOX5))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.119+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -> cat(p(HGNC:ALOX5))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10691962

4
value: Generation of endogenous ROS from mitochondria by antimycin A also lead to a threefold upregulation of 5-LO activity in B-cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10691962

Selventa

RAB8KJ6FWGn ID5btJocgXIjnLOOSd-X 7PXLvw2A9UVg
has assertion: kin(p(PFH:"MAPK Erk1/3 Family")) => p(HGNC:SH2D3C,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.130+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"MAPK Erk1/3 Family")) => p(HGNC:SH2D3C,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10692442

5
value: treatment of cells with epidermal growth factor or nerve growth factor increased the phosphorylation level of Chat, phosphorylation of Chat by MAP kinase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10692442

Selventa

RAN2ywTP-C3xwdmYWeeIuL9D8aZ8Hq cu29jkdAFFAQMQ
has assertion: tscript(complex(NCH:"Nfkb Complex")) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.132+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCH:"Nfkb Complex")) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10692445

3
value: Administration of a LacZ-expressing adenoviral vector induces NFkB DNA and correlates with the up-regulation of Fas (CD95) mRNA
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10692445

Selventa

RABTiIv7rFoo4XNOZuvGx2Sc94wta8Oca-5yEi8yJAF4Y
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> kin(p(PFH:"PRKC Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.146+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> kin(p(PFH:"PRKC Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10692485

4
value: Phorbol-12-myristate-13-acetate, a PKC activator, robustly increased RGS2. This signal was attenuated by the PKC inhibitor GF 109203X (50 +/- 4%) and by phorbol-12, 13-dibutyrate-mediated down-regulation of PKC
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10692485

Selventa

RADe31lU2m4muh5z7WJSNoSS2aMRjx199TEOzpzqwKZRI
has assertion: a(CHEBI:"okadaic acid") -| (kin(p(PFR:"Prka Family")) -> r(RGD:Hmox1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.149+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"okadaic acid") -| (kin(p(PFR:"Prka Family")) -> r(RGD:Hmox1))
label: kin(p(PFR:"Prka Family")) -> r(RGD:Hmox1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10692503

6
value: Simultaneous treatment with OA plus dibutyryl cAMP caused a synergistic up-regulation of steady-state levels of HO-1 mRNA, and the specific protein kinase A inhibitor KT5720 markedly reduced the OA-dependent HO-1 mRNA induction.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10692503

Selventa

RAOL2pBMQYo9hkdxcdROm8Gnr57bGi 80xrBb7p-exOdc
has assertion: complex(p(MGI:Npy1r),p(MGI:Npy)) -> path(SDIS:"food intake")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.160+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(MGI:Npy1r),p(MGI:Npy)) -> path(SDIS:"food intake")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10698177

5
value: The icv NPY-induced food intake was remarkably reduced in Y1-/- mice The Y1 receptor therefore plays a dominant role in NPY-induced feeding
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10698177

Selventa

RAOJOeLbTDiq7Ouo5dxKdWgMqbSRwVRrBwOT4vrfhkYGw
has assertion: p(MGI:Crh) -> sec(a(SCHEM:Epinephrine))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.163+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Crh) -> sec(a(SCHEM:Epinephrine))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10698191

4
value: CRH KO mice had significantly lower plasma epinephrine and higher norepinephrine than WT mice at baseline, and delayed epinephrine secretion during restraint.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10698191

Selventa

RAFJT-bsnE6rPyE1MIddFtJKhUMKhgihf8tZpiOoOVsho
has assertion: a(SCHEM:Stanolone) -| bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.166+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Stanolone) -| bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10698512

2
value: Exposure to high dose dihydrotestosterone (DHT) inhibits population growth of the human prostate carcinoma cell line, LNCaP.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10698512

Selventa

RAHaPrttuh9RNO3-KAeAfX53ud32myyiLC9pv2khuEUCU
has assertion: kin(p(HGNC:PDPK1)) => kin(p(PFH:"PRKA Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.173+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PDPK1)) => kin(p(PFH:"PRKA Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10698680

6
value: PDK1 has now been shown to play a central role in activating many of the AGC subfamily members (reviewed in [150,151]). Apart from phosphorylating PKB on Thr308, PDK1 phosphorylates the equivalent residues on PKC isoforms [48,152,153], p70-S6K [32,154], the three isoforms of SGK [27,28,155] and PKA [156] (Figure 6).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10698680

Selventa

RAMEqBY12w 7DbfMR6iWmXebJI-gHSmjLXgcgT88EWDbA
has assertion: kin(p(HGNC:PDPK1)) => kin(p(PFH:"PRKC Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.174+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PDPK1)) => kin(p(PFH:"PRKC Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10698680

6
value: PDK1 has now been shown to play a central role in activating many of the AGC subfamily members (reviewed in [150,151]). Apart from phosphorylating PKB on Thr308, PDK1 phosphorylates the equivalent residues on PKC isoforms [48,152,153], p70-S6K [32,154], the three isoforms of SGK [27,28,155] and PKA [156] (Figure 6).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10698680

Selventa

RACwTBY YTcQQe95ex0wYt57ZXqK2noWECTnPBAq7Jko
has assertion: a(CHEBI:"reactive oxygen species") -> bp(GO:"response to oxidative stress")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.191+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -> bp(GO:"response to oxidative stress")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10699758

2
value: Free radicals and other ROS are generated by all aerobic cells and are known to participate in a wide variety of deleterious reactions [1]. A number of studies have also demonstrated that bursts of oxidant production as well as dramatic changes in the activities of various antioxidant defenses are closely associated with alterations in gene expression in a variety of tissues from phylogenetically diverse organisms [1-3]. Free radical reactions have been observed to influence molecular and biochemical processes and to directly cause some of the changes observed in cells during differentiation, aging, and transformation [3-9]. These observations have been interpreted to suggest that cells evolved strategies to utilize ROS as biological stimuli [2,8 -11]. Furthermore, ROS and antioxidants are known to influence the expression of a number of genes and signal transduction pathways [1,12-17] and are thought to act as subcellular messengers for certain growth factors [11,13,18,19]. Indeed, the last decade has seen rapid if not explosive growth in the number of genes shown to be influenced by redox changes as well in as those that exert downstream effects through increased ROS formation. This review article is intended to provide a convenient summary of known redox effects on gene expression. Because nearly half of the effects discussed involve members of the MAP kinase and NF-kB signaling pathways or genes regulated by these pathways, a detailed discussion of these signal transduction pathways is also presented. Although we have intentionally kept our overview brief, we include a short discussion of the various species and tissue-specific differences in redox effects that are known to exist as well a summary of the molecular basis of some of these differences. Cell state transitions leading to transformation, differentiation, and senescence tend to cause large changes in cellular redox state. Our discussion concludes with a brief overview of potential consequences of redox[cell cut: 3950 characters, first 2000 kept]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10699758

Selventa

RAD5R6xPILXW43891fcVGnFdSO4RdqZd4SS6gHS5cB-Fk
has assertion: p(EGID:10454) => kin(p(HGNC:MAPK14))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.209+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:10454) => kin(p(HGNC:MAPK14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10702308

5
value: TAK1, a member of the mitogen-activated kinase kinase kinase family, is activated in vivo by various cytokines, including interleukin-1 (IL-1), or when ectopically expressed together with the TAK1-binding protein TAB1. However, this molecular mechanism of activation is not yet understood. We show here that endogenous TAK1 is constitutively associated with TAB1 and phosphorylated following IL-1 stimulation. Furthermore, TAK1 is constitutively phosphorylated when ectopically overexpressed with TAB1. In both cases, dephosphorylation of TAK1 renders it inactive, but it can be reactivated by preincubation with ATP. A mutant of TAK1 that lacks kinase activity is not phosphorylated either following IL-1 treatment or when coexpressed with TAB1, indicating that TAK1 phosphorylation is due to autophosphorylation. Furthermore, mutation to alanine of a conserved serine residue (Ser-192) in the activation loop between kinase domains VII and VIII abolishes both phosphorylation and activation of TAK1. These results suggest that IL-1 and ectopic expression of TAB1 both activate TAK1 via autophosphorylation of Ser-192.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10702308

Selventa

RAJtRNSZ3u9iBOWpohv1UbpPT2mX5z8JL--ke1O50keMc
has assertion: p(PFR:"Plcg Family") -> kin(p(PFR:"Prkc Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.211+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(PFR:"Plcg Family") -> kin(p(PFR:"Prkc Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10704499

5
value: PC12-E2 cells were treated with the specific PKC inhibitor Calphostin C (400 nM). This treatment led to an inhibition of NCAM-dependent neurite outgrowth. These results confirm that NCAM signaling involves the FGF receptor and PLCgamma and indicate a thus far unrecognized role for PKC in NCAM stimulated outgrowth.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10704499

Selventa

RANT1V8THlWXGTVyZEnhzVhxmGX0uIdJG7uc KwGFIuW4
has assertion: p(HGNC:NOG) -> r(HGNC:GATA4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.212+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NOG) -> r(HGNC:GATA4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10704850

4
value: In contrast, GATA4 expression was enhanced after Noggin treatment.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10704850

Selventa

RAGX2SmSjE4XdpPKRAOWjdXb3W-APdqjxxgwcf8uIYMqo
has assertion: a(CHEBI:progesterone) -| p(HGNC:BCL2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.214+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:progesterone) -| p(HGNC:BCL2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10705995

3
value: After 24 h of exposure of T47-D cells to either 1 or 10 microM progesterone, we observed a marked down-regulation of protooncogene bcl-2 protein and mRNA levels.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10705995

Selventa

RAEvUyEegAqTz1FbVD5lArGlEZNo YqYXYYVxgtYohpPI
has assertion: a(CHEBI:progesterone) -| bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.215+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:progesterone) -| bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10705995

2
value: Progesterone inhibits the proliferation of normal breast epithelial cells in vivo, as well as breast cancer cells in vitro.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10705995

Selventa

RAH0 cYUC0tCAJucy1VvArl4ZGEw4vs9Vynl6wDyDbYv8
has assertion: a(CHEBI:progesterone) -> bp(MESHPP:Apoptosis)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.219+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:progesterone) -> bp(MESHPP:Apoptosis)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10705995

2
value: progesterone at relative high physiological concentrations, but comparable to those seen in plasma during the third trimester of human pregnancy, exhibited a strong antiproliferative effect on breast cancer cells and induced apoptosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10705995

Selventa

RAMjD 8eZddxUQ9zLAqzY8a31Phoo2crohrs9tyfWxLdU
has assertion: p(HGNC:KITLG) -> p(HGNC:LIF)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.223+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:KITLG) -> p(HGNC:LIF)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10706861

4
value: Interleukin 1alpha (IL-1alpha), IL-1beta, IL-3, IL-6, IL-8, tumour necrosis factor (TNF-alpha) and SCF (both at 10 ng/ml) stimulate LIF production.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10706861

Selventa

RAI7sXpD wyk8LrhblfyjkXrcGUtS7inXeTgSe18moa c
has assertion: tscript(p(HGNC:"NKX2-5")) -> r(HGNC:NAB2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.228+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:"NKX2-5")) -> r(HGNC:NAB2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10710348

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10710348

Selventa

RADsCEzCnujB1B9gHUiEsAljq23F2 4sB0BvA1rihp50s
has assertion: a(CHEBI:glutathione) -| r(HGNC:FASLG)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.231+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glutathione) -| r(HGNC:FASLG)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10711676

3
value: tBH treatment of hRPE cells resulted in increased expression of FasL and Fas. Glutathione and NAC completely abrogated tBH-induced increase in FasL and Fas expression
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10711676

Selventa

RAFSItKyqqrhwfvbBmEH7EerWpadb920VF5-76-AbouSc
has assertion: p(MGI:Lif) -> bp(GO:"macrophage chemotaxis")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.239+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Lif) -> bp(GO:"macrophage chemotaxis")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10712626

3
value: Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10712626

Selventa

RAJR0 b84pFObuGEstxY9LQpv7rkNNfwTAKwsvclc9fiU
has assertion: kin(p(HGNC:ATM)) => p(HGNC:EIF4EBP1,pmod(P,S,11))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.248+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:ATM)) => p(HGNC:EIF4EBP1,pmod(P,S,11))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10713094

5
value: PhosphoElm data from PMID 15212693
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10713094

Selventa

RAJcV3o5JiueTdLDoekqV0UeaK2UvmTAp7FIfF6PcwAOc
has assertion: complex(p(HGNC:CD44),p(HGNC:FGF4)) => p(HGNC:FGF4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.249+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:CD44),p(HGNC:FGF4)) => p(HGNC:FGF4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10713114

6
value: # Ariadne: In addition, CD44 HSPG isoforms identified in the embryonic mouse apical ectodermal ridge have been shown to bind and present FGF-4 and FGF-8 during limb bud development in embryonic mice ( 22 ) and CD44 HSPGs from tumor cells have been shown to present hepatocyte growth factor as a mechanism to increase tumor cell dissemination ( 23 ). [Binding]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10713114

Selventa

RANgGq4JVVp9BDxzF3kpqB3OjXcdLX2mmqA9-97JqyMZU
has assertion: complex(p(HGNC:CD44),p(HGNC:FGF2)) -> kin(p(HGNC:FGFR1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.254+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

complex(p(HGNC:CD44),p(HGNC:FGF2)) -> kin(p(HGNC:FGFR1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10713114

7
value: Furthermore, we show these isoforms are preferentially modified with heparan rather than chondroitin sulfate, bind the macrophage-derived growth factors FGF-2, vascular endothelial growth factor, and heparin-binding epidermal growth factor with varying affinities (K(d) 25-330 nM) and in the case of FGF-2, can stimulate productive binding to the high affinity tyrosine kinase FGF receptor 1 (FGFR1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10713114

Selventa

RAIfgW817GFiSS4UQmagz2K8lJs1f1H1CAJTIoWWsMyh0
has assertion: kin(p(HGNC:MAP2K4)) -> (kin(p(HGNC:MAP2K7)) -> kin(p(HGNC:MAPK10)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.269+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAP2K4)) -> (kin(p(HGNC:MAP2K7)) -> kin(p(HGNC:MAPK10)))
label: kin(p(HGNC:MAP2K7)) -> kin(p(HGNC:MAPK10))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10715136

Selventa

9
value: Measuring catalysis under Vmax conditions showed MKK4 + MKK7-activated JNK3 alpha 1 had Vmax 715-fold greater than nonactivated JNK3 alpha 1 and MKK7-activated JNK3 alpha 1 had Vmax 250-fold greater than nonactivated JNK3 alpha 1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10715136

RAFaAlViiM9WSeHNG-m2BCz Zlz7UcqI92VseVco6Z8Qs
has assertion: kin(p(HGNC:MAP2K7)) -> p(HGNC:MAPK10,pmod(P,T))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.271+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAP2K7)) -> p(HGNC:MAPK10,pmod(P,T))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10715136

5
value: These data suggest that MKK7 was largely responsible for JNK3 alpha 1 activation and that a single threonine phosphorylation may be all that is needed for JNK3 alpha 1 to be active
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10715136

Selventa

RAFaNKqcqgyhHvkK8qk0bhv-F9wQ1ooJzvRvvvhJN3nmg
has assertion: a(CHEBI:"trichostatin A") -| bp(GO:"G1/S transition of mitotic cell cycle")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.274+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"trichostatin A") -| bp(GO:"G1/S transition of mitotic cell cycle")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10716680

2
value: Butyrate blocked cells mainly in the G(1) phase of the cell cycle, whereas trichostatin A was inhibitory in both G(1) and G(2) phases.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10716680

Selventa

RADaUqzxXJAXl02YxHcEkfQgEm MUcYkgey5wnk1zEnxw
has assertion: a(CHEBI:"trichostatin A") -| r(HGNC:CCND1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.276+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"trichostatin A") -| r(HGNC:CCND1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10716680

3
value: Trichostatin A showed similar effects on cyclin D1 and D3. Butyrate and trichostatin A stimulated p21 expression both at the mRNA and protein levels
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10716680

Selventa

RACFW9Jwi-g9pAMa6LkTg09mDCoQKRCJ7uyhnj6W-B6Cs
has assertion: phos(p(HGNC:PTEN)) -| kin(p(HGNC:ILK))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.281+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(HGNC:PTEN)) -| kin(p(HGNC:ILK))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10716737

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10716737

Selventa

RAI84 JCUHNKuaHujzSRdctZ9wrhX3KM4 TnpgOCJM Sk
has assertion: cat(p(HGNC:FGD3)) -> gtp(p(HGNC:CDC42))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.287+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:FGD3)) -> gtp(p(HGNC:CDC42))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10721717

6
value: Microinjection studies show that Fgd3 stimulates fibroblasts to form filopodia, actin microspikes formed upon the stimulation of Cdc42
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10721717

Selventa

RANwBy9OE-ZPdJo8eOtsJJN MPL-e5YuubaaxGA7S8pZ4
has assertion: p(MGI:Tnf) -> p(MGI:Irs1,pmod(P,S,307))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.295+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Tnf) -> p(MGI:Irs1,pmod(P,S,307))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10722755

4
value: Serine 307 is a major site of JNK phosphorylation in IRS-1. Mutation of serine 307 to alanine eliminates phosphorylation of IRS-1 by JNK and abrogates the inhibitory effect of TNFalpha on insulin-stimulated tyrosine phosphorylation of IRS-1. These results suggest that phosphorylation of serine 307 might mediate, at least partially, the inhibitory effect of proinflammatory cytokines like TNFalpha on IRS-1 function.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10722755

Selventa

RAPLcDjfDte2mlRAYYoOOYmDdwatWDhKlndHeh9SLbeWE
has assertion: p(HGNC:ATF1,pmod(P)) => tscript(p(HGNC:ATF1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.296+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:ATF1,pmod(P)) => tscript(p(HGNC:ATF1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10723128

5
value: ATF1 and CREB can be phosphorylated by Rsk2 which is a protein kinase directly activated by Erk MAP kinase. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10723128

Selventa

RAEMql1E0FsG7AGIozN4lo hqairT2tOIKVPuLbz-YjQI
has assertion: kin(p(HGNC:MAPK1)) => p(HGNC:ELK4,pmod(P))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.306+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MAPK1)) => p(HGNC:ELK4,pmod(P))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10723128

5
value: We further find that the FAP1 site binds ATF1 and CREB from HeLa nuclear extracts and that the phosphorylation of these factors is induced by TPA. ATF1 and CREB can be phosphorylated by Rsk2(RPS6KA3) which is a protein kinase directly activated by Erk (MAPK1) MAP kinases. These results suggest a signaling pathway in which Erk MAP kinase activates the c-fos enhancer by direct phosphorylation of p62TCF and by activation of Rsk related kinases that phosphorylate ATF1 and CREB.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10723128

Selventa

RAPeprih-ktu37ncIyuEd-IZVamMKnwQIIGWwUqIMrYPA
has assertion: p(RGD:Ccnd1) -> bp(GO:"cell cycle")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.311+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ccnd1) -> bp(GO:"cell cycle")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10723135

3
value: In clones of REF/Myc ectopically expressing eIF4E, resistance to apoptosis paralleled steady state levels of cyclin D1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10723135

Selventa

RAKOsH-SQnengcLMgA2gH3IfrWDguV1iy3OjBlXV1fPkA
has assertion: p(RGD:Ccnd1) -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.312+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ccnd1) -> bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10723135

3
value: In clones of REF/Myc ectopically expressing eIF4E, resistance to apoptosis paralleled steady state levels of cyclin D1.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10723135

Selventa

RAN3dc-MMbfkdSQrSw4S0DdxM4Ue50ptJTGVzpH7ryzOY
has assertion: a(CHEBI:"nitric oxide") -> r(RGD:Akr1b1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.324+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"nitric oxide") -> r(RGD:Akr1b1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10727516

3
value: Spontaneous NO donors, S-nitroso-N-acetylpenicillamine (SNAP) and 3-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-propanamin e, elicited a dose-dependent increase in AR mRNA to a maximum of 7-fold in 12 h.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10727516

Selventa

RAGZ5wiZumQzl7Nn-yK2dOetia4yCDflJBSFqBi43P7 Y
has assertion: a(CHEBI:"hydrogen peroxide") -> complex(p(RGD:Egfr),p(RGD:Shc1),p(RGD:Grb2),p(RGD:Sos1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.329+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"hydrogen peroxide") -> complex(p(RGD:Egfr),p(RGD:Shc1),p(RGD:Grb2),p(RGD:Sos1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10727932

7
value: H2O2 induced the phosphorylation of the EGF receptor and the formation of a receptor complex comprising Shc, Grb2, Sos, and the EGF receptor
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10727932

Selventa

RAEpuhiSJXjJYRTT0RTLvvcDOrxVfjCrHTFJvqmN5W57I
has assertion: p(HGNC:NGF) -> r(HGNC:ALDH1A2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.335+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NGF) -> r(HGNC:ALDH1A2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10729354

4
value: NGF induces transcription of the RA-synthesizing enzyme RALDH-2, as well as detectable release of newly synthesized all- trans -RA.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10729354

Selventa

RAJfg9SiArij7uNaa8in2B6-59dz8Obh7QV6G4RRbXZCU
has assertion: p(HGNC:IL6) -> a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.360+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IL6) -> a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10729607

3
value: Cells and organs producing PAF in response to exogenous stimulations Neutrophils Human IL-6 Human GM-CSF and zymosan Eosinophils Human IgG, IL-5, PMA Monocytes Human LPS [361] Human HIV infection Peritoneal macrophages Mouse HGF, TNF-a Lung mast cells Human Anti-IgE [363] Bone marrow mast cells Mouse Monoclonal IgE and antigen
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10729607

Selventa

RAPeb9kfxJyrEuH5GpR3b0PUbicoDZqUeFz9lVJ2oiu5Y
has assertion: cat(p(HGNC:TLR4)) -> a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.365+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:TLR4)) -> a(SCHEM:"1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10729607

4
value: Cells and organs producing PAF in response to exogenous stimulations Neutrophils Human IL-6 Human GM-CSF and zymosan Eosinophils Human IgG, IL-5, PMA Monocytes Human LPS [361] Human HIV infection Peritoneal macrophages Mouse HGF, TNF-a Lung mast cells Human Anti-IgE [363] Bone marrow mast cells Mouse Monoclonal IgE and antigen
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10729607

Selventa

RAAaBsQpqvYT7gd7UghaNtIKTucKLx9I7pJsS7B3n6sG8
has assertion: tscript(p(MGI:Trp53)) => r(MGI:Perp)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.371+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Trp53)) => r(MGI:Perp)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10733530

5
value: # Jubilant: PERP is a direct target of 53, involved in p53-dependent apoptosis. High level PERP expression correlated with the induction of cell death, with 21 percent of cells undergoing apoptosis by 16 hours. Accumulation of high levels of PERP gene expression is dependent on p53, E1A and DNA damage which are all essential for E1A-induced apoptosis in mouse endothelial fibroblasts.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10733530

Selventa

RAMar7EIb0lenFZCsoB1rQSkZWvK9-R RE2rg0qGz YVI
has assertion: p(RGD:Ccl5) -> cat(p(RGD:Ccr1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.385+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(RGD:Ccl5) -> cat(p(RGD:Ccr1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10734056

5
value: To investigate the regulation of the CCR1 chemokine receptor, a rat basophilic leukemia (RBL-2H3) cell line was modified to stably express epitope-tagged receptor. These cells responded to RANTES (regulated upon activation normal T expressed and secreted), macrophage inflammatory protein-1alpha, and monocyte chemotactic protein-2 to mediate phospholipase C activation, intracellular Ca(2+) mobilization and exocytosis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10734056

Selventa

RABJHIOsvyTDzsTzM5wZIBt7cre4jKBErrBSXn4S5kLgs
has assertion: p(MGI:Ngf) -> r(MGI:Mmp3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.398+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ngf) -> r(MGI:Mmp3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10734128

4
value: NAB2 overexpression blocked NGF-dependent differentiation and prevented NGF induction of TGF-beta1, MMP3 and p21waf1
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10734128

Selventa

RAAPuFwqyKqZFlxTduVmNJqxSiB-JEc3c48J3ZlCxSUoM
has assertion: tscript(p(PFH:"E2F Family")) -> r(HGNC:CDKN2A)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.462+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(PFH:"E2F Family")) -> r(HGNC:CDKN2A)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10740816

5
value: a feedback loop exists through which ARF levels are negatively regulated by p53. Significantly, ARF expression is positively regulated by members of the E2F family of transcription factors
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10740816

Selventa

RAIZFjLOFPsuTDk6udKH6D-kuXu2ve25dx4Ce7xEfTZqA
has assertion: a(CHEBI:"carbon monoxide") -| r(HGNC:IL1B)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.466+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"carbon monoxide") -| r(HGNC:IL1B)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10742149

3
value: Both in vivo and in vitro, carbon monoxide at low concentrations differentially and selectively inhibited the expression of lipopolysaccharide-induced pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and macrophage inflammatory protein-1beta and increased the lipopolysaccharide-induced expression of the anti-inflammatory cytokine interleukin-10.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10742149

Selventa

RAKtJpXxCoriIc0EzsZkRtYVXk74TKPmsWaKbc8NB11i8
has assertion: a(CHEBI:"reactive oxygen species") -> kin(p(RGD:Syk))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.473+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"reactive oxygen species") -> kin(p(RGD:Syk))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10744701

4
value: These data indicate that endogenous reactive oxygen species are necessary for the activation of p56(Hck), p72(Syk), and p77(Btk) by spores; they also indicate that some species of spores are capable of activating tyrosine kinases independent of superoxide anion.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10744701

Selventa

RAElx8YPuR7Wnjsgf0DHXcbObLSHHc5pAEta Y9Ux2eD0
has assertion: a(SCHEM:"serum leptin") -| r(HGNC:TMED9)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.488+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"serum leptin") -| r(HGNC:TMED9)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10744732

3
value: By using this process we have identified five genes (POMC, PC2, prolactin, HSGP25L2G, and one novel) that are both abnormally expressed in the pituitaries of obese mice and are sensitive to the effects of leptin POMC, PC2 and HSGP25L2G expressions were decreased in response to leptin and prolactin expression was increased
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10744732

Selventa

RAButcSRR9WPALV4lB-VAVOro8FYDu0XqSirkJj5CLjF4
has assertion: a(SCHEM:fibrate) => tscript(p(HGNC:PPARA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.492+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:fibrate) => tscript(p(HGNC:PPARA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10744771

4
value: Fibrates are widely used hypolipidemic drugs that regulate the expression of many genes involved in lipid metabolism by activating the peroxisome proliferator-activated receptor alpha (PPARalpha)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10744771

Selventa

RAEgvvtKjfBwaeVrwG2sodFpMgvFbXTIbK6fCUH9b4g2M
has assertion: cat(p(RGD:Adora1)) -| a(SCHEM:"serum leptin")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.504+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Adora1)) -| a(SCHEM:"serum leptin")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10746648

4
value: Rats were treated with the A1AR agonist N6-cyclopentyladenosine (CPA), and changes in circulating levels of leptin and leptin gene expression were examined. Serum leptin levels rose 2- to 10-fold, with peak increases seen 8-16 h after injection of CPA (P < 0.05)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10746648

Selventa

RAA-2KQODLaK7uUBO0GEZkL-B8K3WXnPpjCDSpMVMVg7E
has assertion: a(CHEBI:"trichostatin A") -| r(HGNC:TAF9)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.509+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"trichostatin A") -| r(HGNC:TAF9)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10746741

3
value: trichostatin A (TSA), an inhibitor of histone deacetylases Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10746741

Selventa

RAKQwGBvRoIiKglmPB4S5CmlwlRtrH5EL5IWHjYKLauh4
has assertion: a(CHEBI:"trichostatin A") -> r(HGNC:ID2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.526+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"trichostatin A") -> r(HGNC:ID2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10746741

3
value: trichostatin A (TSA), an inhibitor of histone deacetylases Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10746741

Selventa

RANdIxI3HwV bYGV2vGVGVhhxosCvTSoppPF3mZ3uiszA
has assertion: a(CHEBI:"trichostatin A") -> r(HGNC:ID3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.527+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"trichostatin A") -> r(HGNC:ID3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10746741

3
value: trichostatin A (TSA), an inhibitor of histone deacetylases Complex hybridization of cDNA arrays revealed repression of Bcl-xL, CRAB2 and TFIID/TAFII31 as well as induction of p21waf1/cip1, GATA-2, hsp86, ID1, ID2 and ID3 mRNA expression, which could be verified by Northern blotting.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10746741

Selventa

RAKMR7nSJpVTi0nggKVx6f6GZJLSIvVxqxDTdL8YrEjVw
has assertion: kin(p(HGNC:IGF1R)) -> kin(p(HGNC:JAK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.545+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:IGF1R)) -> kin(p(HGNC:JAK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10747872

6
value: tyrosine phosphorylation of STAT3, JAK1, and JAK2 was increased upon IGF-I stimulation of endogenous IGF-IR in 293T cells transfected with the respective STAT or JAK expression vector.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10747872

Selventa

RAOJS23VTksBGgg NfBsKum1XdvbJL-q2IfcmVj-wQfj0
has assertion: kin(p(HGNC:IGF1R)) -> kin(p(HGNC:JAK2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.546+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:IGF1R)) -> kin(p(HGNC:JAK2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10747872

6
value: tyrosine phosphorylation of STAT3, JAK1, and JAK2 was increased upon IGF-I stimulation of endogenous IGF-IR in 293T cells transfected with the respective STAT or JAK expression vector.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10747872

Selventa

RAOdn PJTV9ubY4yWCxUYdUB0CbS07WJuWPRC3H07Apes
has assertion: p(HGNC:TNF) -> kin(complex(NCH:"CK II Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.548+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> kin(complex(NCH:"CK II Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10747897

4
value: Here we demonstrate that the stress signaling agents anisomycin, arsenite, and tumor necrosis factor-alpha stimulate the specific enzyme activity of CK2 in the human cervical carcinoma HeLa cells by up to 8-fold, and this could be blocked by the p38 MAP kinase inhibitor SB203580.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10747897

Selventa

RANS2XPUc15DM5JQe4BP2jHpUHCDZwrikWD9nOQBTauHc
has assertion: tscript(p(MGI:Cebpb)) -| path(SDIS:"muscle insulin receptor signaling pathway")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.551+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Cebpb)) -| path(SDIS:"muscle insulin receptor signaling pathway")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10747954

4
value: These results demonstrate that C/EBPbeta deletion decreases plasma FFA levels and increases insulin signal transduction specifically in skeletal muscle, and both contribute to increased whole-body insulin sensitivity.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10747954

Selventa

RAKOpvwuefuWyp7pXu29-XhqCfsaXL2ccZKP0HVxbmjXE
has assertion: tscript(complex(NCM:"AP-1 Complex")) -> r(MGI:Trp53)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.558+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(complex(NCM:"AP-1 Complex")) -> r(MGI:Trp53)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10747965

4
value: ability of v-Maf to activate p53 expression
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10747965

Selventa

RAP66j2Gnk5HOeSQwcjoJu2DPUaOZ5fK18lbCCgmrftFA
has assertion: tscript(p(HGNC:PBX2)) => r(HGNC:COL5A2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.571+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:PBX2)) => r(HGNC:COL5A2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10748126

5
value: DNA binding assays and cell transfection experiments revealed that the bipartite core sequence of FPB (5'-ATCAATCA-3') binds the PBX1/2, PREP1, and HOXB1 proteins, and this in turn leads to promoter transactivation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10748126

Selventa

RANmgWf1Gm2LQZSHFgOLCM9t7TPzzeieePkowpmphk92A
has assertion: tscript(p(HGNC:PKNOX1)) => r(HGNC:COL5A2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.572+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:PKNOX1)) => r(HGNC:COL5A2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10748126

5
value: DNA binding assays and cell transfection experiments revealed that the bipartite core sequence of FPB (5'-ATCAATCA-3') binds the PBX1/2, PREP1, and HOXB1 proteins, and this in turn leads to promoter transactivation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10748126

Selventa

RAIyeiGwjrLIhkbqIkAfu343kdf2R2haePzZVq0jEVG9Y
has assertion: tscript(p(HGNC:ZNF202)) =| r(HGNC:APOC3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.574+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:ZNF202)) =| r(HGNC:APOC3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10748193

5
value: Additional fragments derived from the promoters of phospholipid transfer protein and hepatic nuclear factor-4 (HNF4) and the apoCIII enhancer that had been shown to bind GST.ZF3-8 in vitro were also used in reporter assays. Transcriptional repression in the presence of ZNF202 was similar to the one observed for the apoE and apoAIV promoters (Table I)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10748193

Selventa

RAEYFJcaKJTXTi29IZhDdLGmZ2sXJYxf8e8pKrA2qPuIE
has assertion: tscript(p(HGNC:ZNF202)) =| r(HGNC:APOA4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.578+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:ZNF202)) =| r(HGNC:APOA4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10748193

5
value: Fig. 6. Repression of apoAIV and apoE promoters by ZNF202 m1 in HepG2 cells. ......we used several reporter constructs containing portions of the apoE and apoAIV genes; these fragments all had been shown to bind ZNF202 in gel shift experiments.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10748193

Selventa

RAHq1qfWkoeBJA9PrciqJeuTFq-5dmkdAZqHKvk90FSBo
has assertion: tscript(p(HGNC:ZNF202)) =| r(HGNC:APOE)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.580+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:ZNF202)) =| r(HGNC:APOE)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10748193

5
value: Fig. 6. Repression of apoAIV and apoE promoters by ZNF202 m1 in HepG2 cells. ......we used several reporter constructs containing portions of the apoE and apoAIV genes; these fragments all had been shown to bind ZNF202 in gel shift experiments.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10748193

Selventa

RADXg3A4yXSb edMg2bmpIsiyhOCHxjfPi 1LSyB3GwRE
has assertion: p(MGI:Il17a) -> p(MGI:Icam1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.584+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Il17a) -> p(MGI:Icam1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10748240

4
value: In embryonic fibroblasts (EFs) derived from TRAF6 knockout mice, IL-17 failed to activate the IkappaB kinases (IKKs) and JNK. Consequently, IL-17-induced IL-6 and intercellular adhesion molecule 1 expression in the TRAF6-deficient cells was abolished.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10748240

Selventa

RACS-MqoIq2PqrM9xNejzX1tqscaq4z5Rr-QvK1HSb2Fk
has assertion: p(MGI:Il17a) -> p(MGI:Icam1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.587+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Il17a) -> p(MGI:Icam1)
label: p(MGI:Traf6) -> (p(MGI:Il17a) -> p(MGI:Icam1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10748240

6
value: In embryonic fibroblasts (EFs) derived from TRAF6 knockout mice, IL-17 failed to activate the IkappaB kinases (IKKs) and JNK. Consequently, IL-17-induced IL-6 and intercellular adhesion molecule 1 expression in the TRAF6-deficient cells was abolished.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10748240

Selventa

RADDex2EyT21JhcsudKsp ByGt1Vq1zR1Rs5xGTlacmDg
has assertion: p(MGI:Il17a) -> kin(p(PFM:"Mapk JNK Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.588+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Il17a) -> kin(p(PFM:"Mapk JNK Family"))
label: p(MGI:Traf6) -> (p(MGI:Il17a) -> kin(p(PFM:"Mapk JNK Family")))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10748240

7
value: In embryonic fibroblasts (EFs) derived from TRAF6 knockout mice, IL-17 failed to activate the IkappaB kinases (IKKs) and JNK. Consequently, IL-17-induced IL-6 and intercellular adhesion molecule 1 expression in the TRAF6-deficient cells was abolished.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10748240

Selventa

RALfBKe9PAC6w5ueSBpnVm97yTq4Td2A2 QTnlSxfo3sM
has assertion: cat(p(HGNC:FAS)) -> kin(p(HGNC:MAPK1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.590+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:FAS)) -> kin(p(HGNC:MAPK1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10749152

6
value: phosphorylation of extracellular signal-regulated kinase (ERK), but not of c-Jun NH2-terminal kinase or p38, was induced by cross-linking of Fas
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10749152

Selventa

RAC6 i8sVbQjQciNrDM1RYIdPaTqprJx-I50Qc3HNFMNU
has assertion: p(MGI:Irs1) -> bp(GO:"cell differentiation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.595+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Irs1) -> bp(GO:"cell differentiation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10749573

3
value: osteoblasts from homozygous deficient mice treated with insulin or IGF1 failed to induce tyrosine phosphorylation of cellular proteins and showed reduced proliferation and differentiation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10749573

Selventa

RANyDfT2MexTR98a8Up0nrrh05bN05EHm UBeiRM8GZ5o
has assertion: p(MGI:Irs1) -> bp(GO:"cell proliferation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.596+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Irs1) -> bp(GO:"cell proliferation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10749573

3
value: osteoblasts from homozygous deficient mice treated with insulin or IGF1 failed to induce tyrosine phosphorylation of cellular proteins and showed reduced proliferation and differentiation
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10749573

Selventa

RAHvEQAtucha05ARZ6tbQoWv4RnqnOkCetL3f0dkB7qdg
has assertion: a(SCHEM:Isoproterenol) -> r(HGNC:UCP1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.598+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Isoproterenol) -> r(HGNC:UCP1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10749798

3
value: Administration of norepinephrine to rats and isoproterenol to mice stimulated MT and UCP1 expression in BAT, implying a sympathetically mediated pathway for MT induction.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10749798

Selventa

RAF8LjragB-QjIS3id NZGUEnsCNPfGOY1DrrmDyDJysk
has assertion: p(HGNC:RGS3) -| cat(p(HGNC:EDNRA))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.604+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:RGS3) -| cat(p(HGNC:EDNRA))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10749886

5
value: Both RGS3 and RGS3T bound to endogenous Galpha(q/11) and inhibited endothelin-1-stimulated calcium mobilization and mitogen-activated protein kinase activity to a similar extent.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10749886

Selventa

RAINwcm7HmyPFV5ZJjPtCAnedFuECNZ68LXD9AwN75kEs
has assertion: cat(p(HGNC:EDNRA)) -> a(SCHEM:Calcium)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.605+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:EDNRA)) -> a(SCHEM:Calcium)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10749886

4
value: Both RGS3 and RGS3T bound to endogenous Galpha(q/11) and inhibited endothelin-1-stimulated calcium mobilization and mitogen-activated protein kinase activity to a similar extent.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10749886

Selventa

RALk19sm0bDwW2D Q1KCNyRW5d71yzxdRt-n2-0RYRX8k
has assertion: cat(p(HGNC:EDNRA)) -> kin(p(PFH:"MAPK Erk1/3 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.607+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:EDNRA)) -> kin(p(PFH:"MAPK Erk1/3 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10749886

6
value: Both RGS3 and RGS3T bound to endogenous Galpha(q/11) and inhibited endothelin-1-stimulated calcium mobilization and mitogen-activated protein kinase activity to a similar extent.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10749886

Selventa

RADdkvfGNiy25fnDjXQYaHGday4lLWWJXP7ih5pgNrNcs
has assertion: p(MGI:Mt1) -| r(MGI:Vnn3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.621+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Mt1) -| r(MGI:Vnn3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10753647

4
value: The sequences of the other cDNA fragments were identical to those of contrapsin, transketolase, and vanin-3. The latter two were up-regulated, whereas contrapsin was down-regulated in neonatal MT-null mice.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10753647

Selventa

RAArAw9QQgcvbmJjSsSSm-WQvu5wFy3JZWGGoWxcX5S68
has assertion: cat(p(HGNC:CXCR4)) -> p(HGNC:CRK)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.649+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CXCR4)) -> p(HGNC:CRK)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10753828

5
value: We observed that several other focal adhesion components, including focal adhesion kinase (FAK) and the adaptor molecules Crk and Crk-L, are phosphorylated on SDF-1alpha stimulation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10753828

Selventa

RAGudjfxGDqtnyfA3sx 66sF7mO1duAG0wN7CEZvhTXI
has assertion: kin(p(HGNC:MET)) -> a(SCHEM:"Guanine-nucleotide-releasing factor")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.655+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MET)) -> a(SCHEM:"Guanine-nucleotide-releasing factor")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10753869

4
value: The results presented here delineate a novel signaling pathway from HGF to the GTPase Rap1 which depends on the interaction of the adapter protein CRKL with the exchange factor C3G and could be linked to cell migration.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10753869

Selventa

RALabWGKO38m7HRv8nIVsk76IAYMaVT2XJ2IG8Nv8vCNw
has assertion: kin(p(HGNC:MET)) -> cat(p(HGNC:CRKL))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.656+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:MET)) -> cat(p(HGNC:CRKL))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10753869

6
value: The results presented here delineate a novel signaling pathway from HGF to the GTPase Rap1 which depends on the interaction of the adapter protein CRKL with the exchange factor C3G and could be linked to cell migration.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10753869

Selventa

RABc1-9IwO92-ePhqLz-SiRCO2atjXhtcQK8m8FrGUxEs
has assertion: p(HGNC:CASP8) -> kin(p(HGNC:IKBKB))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.662+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CASP8) -> kin(p(HGNC:IKBKB))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10753878

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10753878

Selventa

RAIJIds6BZ0jIKk1MQRrJ-hs3-dTgX7vr7An R56FCVxA
has assertion: kin(p(PFH:"AKT Family")) -> cat(p(HGNC:BAD))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.668+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"AKT Family")) -> cat(p(HGNC:BAD))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10754327

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10754327

Selventa

RAHkWMKk8kvyK8gAy7OFKfGWxgtBhAkqnKw7V6j7MgXQ0
has assertion: p(HGNC:TNFRSF8) -> p(HGNC:IL10)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.671+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNFRSF8) -> p(HGNC:IL10)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10754341

4
value: IL-4-producing CD30+ clones also produced high levels of IL-10. The production of IL-10 by CD30+ clones was much higher in early than in late Rheumatoid Arthritis.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10754341

Selventa

RAN9uK9TJNLsJb0Z6N2AH8fh6ndycI-e1ss2XnKV5Oj4c
has assertion: tscript(p(PFM:"Nfat Family")) -> tscript(p(MGI:Egr2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.677+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(PFM:"Nfat Family")) -> tscript(p(MGI:Egr2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10755616

6
value: The transcription factors Egr2 and Egr3 are potent activators of FasL expression
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10755616

Selventa

RAJAI1W4O grRnfe7b-OEba5uD28EJrw9lXL2bGZXYl0M
has assertion: tscript(p(PFM:"Nfat Family")) -> tscript(p(MGI:Egr3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.678+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(PFM:"Nfat Family")) -> tscript(p(MGI:Egr3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10755616

6
value: The transcription factors Egr2 and Egr3 are potent activators of FasL expression
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10755616

Selventa

RADIPj0kck1nQLSLFBRu0ZYRjenmHQLo9trjFVnyM6xO8
has assertion: a(CHEBI:aldosterone) -> r(HGNC:ATP1B1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.682+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:aldosterone) -> r(HGNC:ATP1B1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10760051

3
value: Similar responses are observed for the serum and glucocorticoid-regulated kinase and channel-inducing factor genes. All four genes show clear and rapid up-regulation of their mRNA levels by aldosterone, which is paralleled by GR-mediated up-regulation of expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10760051

Selventa

RABqvcNGAFJc9pDfTY03-q5hBew-stu7aUj62Z9H9e4cQ
has assertion: a(CHEBI:aldosterone) -> r(HGNC:FXYD4)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.684+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:aldosterone) -> r(HGNC:FXYD4)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10760051

3
value: Similar responses are observed for the serum and glucocorticoid-regulated kinase and channel-inducing factor genes. All four genes show clear and rapid up-regulation of their mRNA levels by aldosterone, which is paralleled by GR-mediated up-regulation of expression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10760051

Selventa

RAEY3kNmnE5s4VmMlvPfWJCTp4YpF3qZPoDHqM3oGLQlo
has assertion: bp(GO:"histone deacetylation") -| r(MGI:Mat2a)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.693+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

bp(GO:"histone deacetylation") -| r(MGI:Mat2a)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10762065

3
value: evaluated Mat1a and Mat2a methylation in liver and in other tissues, such as kidney Mat1a is hypomethylated in liver and hypermethylated in non-expressing tissues the opposite situation is found in Mat2a histones associated to Mat1a and Mat2a genes showed enhanced levels of acetylation in expressing tissues
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10762065

Selventa

RAH8-njZt-YPExfSvAfQUv4esvvqlnNbQMIP-KaT2quX8
has assertion: cat(p(RGD:Agtr1b)) -> cat(p(RGD:Cyba))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.702+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr1b)) -> cat(p(RGD:Cyba))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10764657

6
value: # Jubilant: It was proved that Reactive oxygen species generation was dependent on P22-PHOX subunit of NADPHoxidase. Transfection with antisense P22-PHOX oligonucleotides reduced the Angiotensin induced Reactive oxygen species induction
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10764657

Selventa

RAC0moicHLl j--ESf gJgqf11bIJ6mmLjakDxswrmQu4
has assertion: cat(p(RGD:Agtr1b)) -> cat(p(RGD:Cyba))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.704+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr1b)) -> cat(p(RGD:Cyba))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10764657

6
value: # Jubilant: It was proved that Reactive oxygen species generation was dependent on P22-PHOX subunit of NADPHoxidase. Transfection with antisense P22-PHOX oligonucleotides reduced the Angiotensin induced Reactive oxygen species induction
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10764657

Selventa

RAIBKFNiKjTgPmYNfeNEAQD0sk DsPOj7TPm80pECsspw
has assertion: cat(p(RGD:Agtr1b)) -> (cat(p(RGD:Cyba)) -> kin(p(RGD:Mapk14)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.714+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr1b)) -> (cat(p(RGD:Cyba)) -> kin(p(RGD:Mapk14)))
label: cat(p(RGD:Cyba)) -> kin(p(RGD:Mapk14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10764657

Selventa

9
value: Ang II also induced the rapid formation of ROS, which could be inhibited by a specific antibody as well as by antisense against the p22phox subunit of the NAD(P)H oxidase. JNK and p38 MAPK, but not ERK, activation was inhibited by an inhibitor of NAD(P)H oxidase. Antisense against p22phox also solely inhibited p38 MAPK but did not affect ERK.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10764657

RACrU7Vdp8qCbsEJk4yifAONTV51c38Mga0YQJ8vuWd2I
has assertion: cat(p(RGD:Agtr2)) -> (cat(p(RGD:Cyba)) -> kin(p(RGD:Mapk14)))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.718+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Agtr2)) -> (cat(p(RGD:Cyba)) -> kin(p(RGD:Mapk14)))
label: cat(p(RGD:Cyba)) -> kin(p(RGD:Mapk14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10764657

Selventa

9
value: Ang II also induced the rapid formation of ROS, which could be inhibited by a specific antibody as well as by antisense against the p22phox subunit of the NAD(P)H oxidase. JNK and p38 MAPK, but not ERK, activation was inhibited by an inhibitor of NAD(P)H oxidase. Antisense against p22phox also solely inhibited p38 MAPK but did not affect ERK.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10764657

RAIFIbqdDGIUnmJS6CQnR9eMyNRs5aDObb1pZGxJLHxaM
has assertion: cat(p(RGD:Cyba)) -> kin(p(RGD:Mapk14))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.720+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(RGD:Cyba)) -> kin(p(RGD:Mapk14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10764657

6
value: Ang II also induced the rapid formation of ROS, which could be inhibited by a specific antibody as well as by antisense against the p22phox subunit of the NAD(P)H oxidase. JNK and p38 MAPK, but not ERK, activation was inhibited by an inhibitor of NAD(P)H oxidase. Antisense against p22phox also solely inhibited p38 MAPK but did not affect ERK.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10764657

Selventa

RAPp8wFNWA3fMoSmsAJpC3V2lycnpAG7ONgGhXR5Z1L0s
has assertion: p(MGI:Tnf) -> cat(p(MGI:Casp8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.734+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Tnf) -> cat(p(MGI:Casp8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10766806

5
value: a dominant-negative mutant of nuclear factor-kappaB-inducing kinase also promoted TNFalpha- and Fas-mediated apoptosis. Expression of either crmA or a dominant-negative mutant of the Fas-associated death domain protein prevented TNFalpha- and Fas-mediated apoptosis. In addition, the caspase inhibitors, DEVD-cho and IETD-fmk, inhibited TNFalpha- and Fas-mediated apoptosis. In Ad5IkappaB-infected hepatocytes, caspases-3 and -8 were activated within 2 h after treatment with anti-Fas antibody or within 6 h after TNFalpha treatment
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10766806

Selventa

RAOEo-o05438wtYnCHVSJjWwoU-gcnuHXbuI5pSEIajso
has assertion: p(MGI:Cftr) -> sec(a(SCHEM:"Chloride(1-)"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.737+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Cftr) -> sec(a(SCHEM:"Chloride(1-)"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10766914

4
value: 1. The isoflavone genistein may either stimulate or inhibit cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels. To investigate how genistein inhibits CFTR, we studied CFTR Cl- channels in excised inside-out membrane patches from cells expressing wild-type human CFTR. 2. Addition of genistein (100 microM) to the intracellular solution caused a small decrease in single-channel current amplitude (i), but a large reduction in open probability (Po). 3. Single-channel analysis of channel block suggested that genistein (100 microM) may inhibit CFTR by two mechanisms: first, it may slow the rate of channel opening and second, it may block open channels. 4. Acidification of the intracellular solution relieved channel block, suggesting that the anionic form of genistein may inhibit CFTR. 5. Genistein inhibition of CFTR Cl- currents was weakly voltage dependent and unaffected by changes in the extracellular Cl- concentration. 6. Channel block was relieved by pyrophosphate (5 mM) and ATP (5 mM), two agents that interact with the nucleotide-binding domains (NBDs) of CFTR to greatly stimulate channel activity. 7. ATP (5 mM) prevented the genistein-induced decrease in Po, but was without effect on the genistein-induced decrease in i. 8. The genistein-induced decrease in i was voltage dependent, whereas the genistein-induced decrease in Po was voltage independent. 9. The data suggest that genistein may inhibit CFTR by two mechanisms. First, it may interact with NBD1 to potently inhibit channel opening. Second, it may bind within the CFTR pore to weakly block Cl- permeation.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10766914

Selventa

RAF2vaoUuMKZ7IEKpi2RcsuL3F6GmmK3YzCaz3W6JOK w
has assertion: a(CHEBI:troglitazone) -| r(HGNC:SERPINE1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.745+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:troglitazone) -| r(HGNC:SERPINE1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10770198

3
value: By contrast, in human aortic smooth muscle cells, 3 microg/mL troglitazone decreased basal PAI-1 expression by 23% (P = 0.037) and decreased transforming growth factor-beta-induced expression by 34% (P = 0.026).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10770198

Selventa

RAGFrl3jhzq4WY1zQVsqgeDe04kbxx8jUUBpEj0MOqnl4
has assertion: p(HGNC:NEDD8) -| p(HGNC:CDKN1B)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.758+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NEDD8) -| p(HGNC:CDKN1B)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10772955

4
value: Cullin-1, a component of SCF, is modified by ubiquitin-like protein Nedd8. The modification site of cullin-1 was shown to be K696 because the K696R mutant was not modified. When the effect of the Nedd8 modification on the SCF(skp2) activity toward p27(kip1) was investigated, the activity was markedly decreased by using the Nedd8-unmodified mutant cullin-1 (K696R), indicating that the modification may play an important role on the SCF(skp2) activity toward p27(kip1).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10772955

Selventa

RANrF77 GjINXC7S6vLt5cR1Ok97nF6PeTNfmbo5mmyEw
has assertion: tscript(p(HGNC:NR2F2)) -| bp(GO:"cell growth")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.759+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:NR2F2)) -| bp(GO:"cell growth")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10772965

4
value: Introduction of COUP-TFII to MDA-MB-435 cells resulted in reduced growth and plating efficiency. Interestingly, COUP-TFII increased the expression of cyclin D1 and p21(WAF1/CIP1) in MDA-MB-435 cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10772965

Selventa

RAPVmB-3Ie7EwAK1LPNTUDwORCWCERqtMHEsduNthklfc
has assertion: tscript(p(MGI:Klf1)) -> r(MGI:Alas2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.761+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(MGI:Klf1)) -> r(MGI:Alas2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10773455

5
value: Putative binding sites for the erythroid-specific nuclear factors GATA-1, NF-E2, and EKLF were identified within the first 300bp region of the mouse ALAS2 5'-flanking region
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10773455

Selventa

RAH3Q6L6pIgoF3YtP4nxA zeT0VCVPC41Ld13wlEQKBvw
has assertion: p(EGID:3630) -| cat(p(HGNC:HSD11B1))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.768+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(EGID:3630) -| cat(p(HGNC:HSD11B1))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10775808

5
value: Treatment with TNFalpha at concentrations of 0.1-10 ng/ml resulted in a dose dependent increase in 11beta-HSD1 reductase activity from 1.5 to 10-fold. Insulin (0.1-100 nM) had no effect under basal conditions, but inhibited the stimulatory effects of TNFalpha (5 ng/ml) on 11beta-HSD1 reductase activity in a dose dependent fashion (8-66%) inhibition).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10775808

Selventa

RAL6yNilmNsYAJM84tb3fUu6D3u soNQ3UY8LIfWOUYlI
has assertion: cat(p(HGNC:BDKRB1)) -> a(SCHEM:Calcium)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.772+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:BDKRB1)) -> a(SCHEM:Calcium)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10777533

4
value: In addition, B1 receptor activation by des-Arg(10)-kallidin induced a rise in cytosolic Ca(2+) that is consistent with B1 receptor pharmacology.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10777533

Selventa

RAJumnUWDn8SXV6Qh5yVBC-o5csCm4mq5tmlKSmTnhX0k
has assertion: phos(p(MGI:Pten)) -| kin(p(PFM:"Akt Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.777+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

phos(p(MGI:Pten)) -| kin(p(PFM:"Akt Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10777587

6
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10777587

Selventa

RAG6SBhV5BENEre0CIRgJdGUXwJaFGJKHfG63ojWWqPeM
has assertion: a(CHEBI:glucocorticoid) -| r(RGD:Atp2b1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.781+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:glucocorticoid) -| r(RGD:Atp2b1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10777776

3
value: PMCA1 was repressed approximately 33% after a high, but not a low dose of the GC, corticosterone (B), suggesting glucocorticoid (but not mineralocorticoid) receptor-mediated repression.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10777776

Selventa

RAED5gpRUmG63YGRsejngm6a0YPCiCGKkVOyDDystqMFY
has assertion: p(HGNC:IKBKB,pmod(P,S,181)) => kin(p(HGNC:IKBKB))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.789+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:IKBKB,pmod(P,S,181)) => kin(p(HGNC:IKBKB))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10779355

5
value: Phosphorylation of two closely spaced serine residues in this domain, at positions 176 and 180 in IKK? and positions 177 and 181 in IKK?, has been shown to be important for IKK kinase activity (22).
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10779355

Selventa

RALPOCkVj-MxHRqxqEp oyq-F 0r5MrKmTFXOdmIFHmRY
has assertion: kin(p(HGNC:CHUK)) => p(HGNC:NFKBIA,pmod(P,S))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.790+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:CHUK)) => p(HGNC:NFKBIA,pmod(P,S))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10779355

5
value: Two related kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta, phosphorylate the IkappaB proteins, leading to their degradation and the subsequent activation of gene expression by NF-kappaB
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10779355

Selventa

RAPHm5mpQa0YLUUo5S16yoRxVTcwG8S1Li6oxKS8VnlBE
has assertion: p(HGNC:HNF1A) -> r(HGNC:UGT2B7)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.793+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:HNF1A) -> r(HGNC:UGT2B7)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10779377

4
value: UGT2B7 promoter activity with the HNF1/AT-rich element was stimulated by cotransfection with HNF1alpha.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10779377

Selventa

RANrlgOM4Y95eaaugeNOWtJiI1YBU4u-l9B6-lCl83ujo
has assertion: p(HGNC:CSF3) -> p(HGNC:GDI1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.795+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:CSF3) -> p(HGNC:GDI1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10779444

4
value: This study determined that the guanosine diphosphate (GDP)-dissociation inhibitor RhoGDI is overexpressed at the protein level in patients' neutrophils and that overexpression is a result of G-CSF treatment.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10779444

Selventa

RAPC6HA3i25sa2fP5qAoOup22vQl wX84GdjmWZJQbDCA
has assertion: tscript(p(HGNC:EP300)) => tscript(p(HGNC:AR))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.796+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:EP300)) => tscript(p(HGNC:AR))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10779504

6
value: p300 and p300/cAMP-response element-binding protein acetylated the AR at a highly conserved lysine-rich motif carboxyl-terminal to the zinc finger DNA-binding domain. [(14)C]acetate-labeling experiments demonstrated that AR acetylation by p300 in cultured cells requires the same residues identified in vitro. Point mutation of the AR acetylation site (K632A/K633A) abrogated dihydrotestosterone-dependent transactivation of the AR in cultured cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10779504

Selventa

RALiitBoBO5rCmboiXU2CmUU62OPCOn0VVUQSKAOHtYQ0
has assertion: cat(p(HGNC:F2)) -> bp(GO:"platelet activation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.799+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:F2)) -> bp(GO:"platelet activation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10780327

4
value: Stimulation of human platelets with thrombin or thrombin receptor agonist peptide (TRAP/ Ser-Phe-Leu-Leu-Arg-Asn) resulted in phosphorylation of the protease-activated receptor 1 (PAR1)
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10780327

Selventa

RANMsOWD-aP9qL4aZUcUJ9iAmhBLWR29nquv25l6i0C0M
has assertion: kin(p(HGNC:PBK)) -> kin(p(HGNC:MAPK14))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.807+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(HGNC:PBK)) -> kin(p(HGNC:MAPK14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10781613

6
value: The transfection of the TOPK gene to COS-7 cells up-regulated a phosphorylation of p38 MAPK but not ERK1/2 or SAPK/JNK.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10781613

Selventa

RACYeZcdWAT00e4mqDLvhrTveiGHaqv-dmOnbaevm3 mA
has assertion: p(MGI:Ifng) -> p(MGI:Psme1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.812+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ifng) -> p(MGI:Psme1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10781831

4
value: PA28 is an interferon-gamma inducible modulator of proteasome function composed of two subunits, i.e. PA28alpha and PA28beta.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10781831

Selventa

RAPgIzpWYvzLMCq8ksvWi8 5uMBl8yqhS5wGesK0cZNSA
has assertion: tscript(p(HGNC:SMAD7)) -| tscript(p(HGNC:SMAD3))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.836+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

tscript(p(HGNC:SMAD7)) -| tscript(p(HGNC:SMAD3))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10781941

6
value: Smad7 was recently shown to antagonize TGF-beta-induced activation of signal-transducing Smad2 and Smad3 proteins
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10781941

Selventa

RAPZ6a9yVNYxkE9IRVyXb1LkobQ92KAi6GevO9EGe-zIs
has assertion: a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:CSF2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.839+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:CSF2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10783130

3
value: GM-CSF promoter constructs were cloned and stably transfected into A549 cells (Figure 5A). All three constructs gave rise to similar levels of inducibility (Figures 5B and 6A–6C). Induction of these constructs by IL-1b was only 1.5- to 2-fold and induction by PMA was 3- to 6-fold (Figure 5),
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10783130

Selventa

RADds75Dv-CEIBOOTLOElbYgzOhNRi0XUgmBgNgd N8x4
has assertion: cat(p(HGNC:FAS)) -> cat(p(HGNC:CASP9))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.849+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:FAS)) -> cat(p(HGNC:CASP9))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10786680

6
value: we demonstrate that two of the early events after Fas ligation are the release of cytochrome c from the mitochondria and activation of caspase-9
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10786680

Selventa

RAMT2qAye7-CcHz1MoOTcUl84HfTkwIW3dGW3IyUHu7Fg
has assertion: p(MGI:Ifng) -> sec(p(PFM:"Txnrd Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.851+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Ifng) -> sec(p(PFM:"Txnrd Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10786696

5
value: we analyzed the expression of TrxR in peripheral blood cells, tumor-transformed leukemia, and melanoma cells and found, in addition to abundant plasma membrane localization, that TrxR was released from these cells. The release was inducible, and physiological stimulation of human monocytes by IFN-gamma, lipopolysaccharide, and interleukin 1alpha significantly increased the number of TrxR-secreting cells
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10786696

Selventa

RAMnnNm-Jk1eJJkISA2Ba7pItRro -t125vtOXvnUoP-8
has assertion: path(SDIS:"laminar shear stress") -| complex(NCH:"NADH Dehydrogenase Complex")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.856+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"laminar shear stress") -| complex(NCH:"NADH Dehydrogenase Complex")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10787179

2
value: Figure 2 in the actual paper.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10787179

Selventa

RAAKxYbCtjVd1gJll9OhPQ1FiblWMEE-xYQolYcZxVRd4
has assertion: path(SDIS:"laminar shear stress") -> r(HGNC:EGR1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.860+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"laminar shear stress") -> r(HGNC:EGR1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10787179

3
value: Figure 2 in the actual paper.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10787179

Selventa

RAD5mfSOxhk-KLRsj Gl2jhOiK2kRwfKPKUEgsXVZ9yMA
has assertion: path(SDIS:"laminar shear stress") -> r(HGNC:F3)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.861+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"laminar shear stress") -> r(HGNC:F3)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10787179

3
value: Figure 2 in the actual paper.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10787179

Selventa

RAB3TkUd6Ug imOOY1xgly5b8nHT8YNeJUTXvR6GhfE4E
has assertion: path(SDIS:"laminar shear stress") -> r(HGNC:HMOX1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.863+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

path(SDIS:"laminar shear stress") -> r(HGNC:HMOX1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10787179

3
value: Figure 2 in the actual paper.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10787179

Selventa

RAEIZlQQWa9PNLn52N4f6Mmv8iEo2Il-TquqtG25REt3w
has assertion: cat(p(HGNC:CASP1)) -| p(HGNC:IL1B)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.885+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CASP1)) -| p(HGNC:IL1B)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10790428

5
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10790428

Selventa

RAOHF0rVa17SdpSxODGA0A 7KkYtqVEpGbc0YxvStVr0g
has assertion: cat(p(HGNC:CASP1)) -> p(HGNC:IL18)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.892+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CASP1)) -> p(HGNC:IL18)
label: cat(p(HGNC:SERPINB9)) -| (cat(p(HGNC:CASP1)) -> p(HGNC:IL18))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10790428

8
value: We report here that the serine proteinase inhibitor (serpin) PI-9 accounts for the endogenous caspase-1 inhibitory activity in human SMCs and prevents processing of the enzyme's natural substrates, IL-1beta and IL-18 precursor.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10790428

Selventa

RADrB1rL epOpSEQ-RKt7vRhqtkXdyYlN2pzRO8yQKZ7k
has assertion: p(MGI:Cabin1) -| phos(complex(NCM:"Calcineurin Complex"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.895+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(MGI:Cabin1) -| phos(complex(NCM:"Calcineurin Complex"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10791979

4
value: differentiation is inhibited at the commitment stage by either treatment with the calcineurin inhibitor cyclosporine A (CSA) or expression of CAIN, a physiological inhibitor of calcineurin.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10791979

Selventa

RAC6WaHCZdF869w2F4g5zXeD3Frw9e4BeTZXItWP-lBTI
has assertion: a(CHEBI:heparin) -> (p(HGNC:IFNG) -> bp(GO:"inflammatory response"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.903+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:heparin) -> (p(HGNC:IFNG) -> bp(GO:"inflammatory response"))
label: p(HGNC:IFNG) -> bp(GO:"inflammatory response")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10792372

4
value: It is known that IFN-gamma can bind cell surface and extracellular heparan sulphate. Furthermore, soluble heparin can inhibit the function of this cytokine, presumably by competitive displacement from the cell surface
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10792372

Selventa

RAGPravFNx3rgW1Sj-7 4gK2ujMcmRk4DiIyr9E7xbwnQ
has assertion: a(CHEBI:"vitamin E") -| cat(p(PFR:"Pla2 Family"))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.908+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"vitamin E") -| cat(p(PFR:"Pla2 Family"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10793193

4
value: At the posttranslational level, alpha-tocopherol inhibits protein kinase C, 5-lipoxygenase and phospholipase A2 and activates protein phosphatase 2A and diacylglycerol kinase
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10793193

Selventa

RAGRQPRlUf4nNNveni5UHSPGWmyX1HPpnkRYUfwWWDQuk
has assertion: cat(p(HGNC:CASP1)) -> cat(p(HGNC:CASP8))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.928+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:CASP1)) -> cat(p(HGNC:CASP8))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799503

6
value: These results demonstrate an additional and novel function for caspase-1 in which Pro-C1 acts to enhance Fas-mediated apoptosis, most probably through facilitation of the activation of caspase-8
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799503

Selventa

RADhYWhn1aWe3ui mY73k3g1-BK5Ibi0wW 9IWQ4swme0
has assertion: kin(p(PFH:"PRKC Family")) -> r(HGNC:COL1A2)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.932+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> r(HGNC:COL1A2)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799556

5
value: # Ariadne: On the other hand, previous studies have shown that acetaldehyde induces the levels of c-Jun through a PKC-dependent mechanism and enhances murine alpha2(I) collagen promoter mediated by PKC activation ( 46 , 47 ). [Expression]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799556

Selventa

RAE6vvTOCyzKGi3mka53slSOuH33Y1udi0UDTggZ3QkLE
has assertion: p(HGNC:TNF) -> p(HGNC:VEGFA)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.936+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:TNF) -> p(HGNC:VEGFA)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799861

4
value: VEGF production induced by IL-1beta, TNF-alpha, and TGF-beta was further increased when CD40L+ L cells were coincubated, by factors of 5.9, 5.5, and 9.6, respectively, which indicated that these cytokines had an additive effect on VEGF production driven by CD40L.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799861

Selventa

RAMA0Ved2 fLNZ1TlC4HRnR9AXdMrxUDBLnx8ORBWscrU
has assertion: p(HGNC:NOS2) -> r(HGNC:PRF1)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.938+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

p(HGNC:NOS2) -> r(HGNC:PRF1)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799885

4
value: Modified assertion
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799885

Selventa

RAJlBKuZr-CNWDuNnejD1dOFI4WpQDta5r7xFRdHWXq24
has assertion: a(SCHEM:Dinoprostone) -> r(MGI:Cd14)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.945+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Dinoprostone) -> r(MGI:Cd14)
label: tscript(complex(NCM:"AP-1 Complex")) -> (a(SCHEM:Dinoprostone) -> r(MGI:Cd14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799905

5
value: # Ariadne: Therefore, the present study demonstrates that PGE 2 has the ability to stimulate AP-1-mediated expression of CD14 in mouse macrophages via cAMP-dependent protein kinase A. [Expression] # Ariadne: PGE 2 -stimulated expression of CD14 was inhibited by antisense c- fos and c- jun oligonucleotides, but not by their sense oligonucleotides. [Expression]
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799905

Selventa

RADsbkNus6JeVtShwHL7q807sin4g5GEGoVBjJE5WJQZU
has assertion: a(SCHEM:Dinoprostone) -> r(MGI:Cd14)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.957+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Dinoprostone) -> r(MGI:Cd14)
label: kin(p(PFM:"Prka Family")) -> (a(SCHEM:Dinoprostone) -> r(MGI:Cd14))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799905

6
value: Protein kinase A inhibitor, N-[2-(p-bromocinnamylamino)ethyl]-5- isoquinolinesulfonamide (H-89), but not protein kinase C inhibitor 3-(1-[3- (dimethylamino)propyl]-1H- indol-3-yl)-4-(1H-indol-3-yl)-1H-py rrole-2,5-dione (GF109203X), abolished the stimulated expression of CD14.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799905

Selventa

RALMMx15pv1opThMk2OpUJ5I8vQvQdTZLw5PJTC4MOfm8
has assertion: a(SCHEM:Dinoprostone) -> r(MGI:Cd14)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.959+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Dinoprostone) -> r(MGI:Cd14)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799905

3
value: we investigated the effect of PG on CD14 expression in mouse macrophages. PGE1, PGE2, and PGA1 among the PGs tested strongly stimulated the expression of the CD14 gene in the cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799905

Selventa

RADBEJFWTJ7E1rbUT1S0xFipAUvE4UX9DuiFAty7RiQaA
has assertion: a(CHEBI:"prostaglandin A1") -> r(MGI:Cd14)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.960+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(CHEBI:"prostaglandin A1") -> r(MGI:Cd14)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799905

3
value: we investigated the effect of PG on CD14 expression in mouse macrophages. PGE1, PGE2, and PGA1 among the PGs tested strongly stimulated the expression of the CD14 gene in the cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799905

Selventa

RAFnQPr-Ettxoy9HnEXZtKHqWURP9CsEed4HpECkFLN1g
has assertion: a(SCHEM:Dinoprostone) -> r(MGI:Cd14)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.961+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

a(SCHEM:Dinoprostone) -> r(MGI:Cd14)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10799905

3
value: we investigated the effect of PG on CD14 expression in mouse macrophages. PGE1, PGE2, and PGA1 among the PGs tested strongly stimulated the expression of the CD14 gene in the cells.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10799905

Selventa

RABGms48NeoIVAjj7s6k-SZquYEyg5dhP0D6VJYjSGwuk
has assertion: cat(p(HGNC:PLAU)) -> bp(GO:"DNA replication")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.963+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:PLAU)) -> bp(GO:"DNA replication")
label: tloc(p(HGNC:PLAU),GOCCACC:"GO:0005886",GOCCACC:"GO:0005737") -> (cat(p(HGNC:PLAU)) -> bp(GO:"DNA replication"))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10801075

7
value: PAs mitogenic stimulation of serum-starved cells was associated with the internalization of their molecules
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10801075

Selventa

RAHo X2IsJxV ZJ4Iovy2hQkO4 zniyx7T7qAu vSo98
has assertion: kin(p(PFH:"PRKC Family")) -> r(HGNC:JUN)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.967+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> r(HGNC:JUN)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10801075

5
value: The biological activity of u-PA, t-PA, as well as that of limiting concentration of FCS (1%), was mediated by PTK and PKC.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10801075

Selventa

RAAdE-mKn9v0Fwdplh71qfh5kMJwc3yDvu4vliGK-cesM
has assertion: kin(p(PFH:"PRKC Family")) -> r(HGNC:MYC)
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.970+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

kin(p(PFH:"PRKC Family")) -> r(HGNC:MYC)
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10801075

5
value: The biological activity of u-PA, t-PA, as well as that of limiting concentration of FCS (1%), was mediated by PTK and PKC.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10801075

Selventa

RAKnvRM Qm8t0uhrCAzLLpR5Z69Si-pWVPZqnGkCg0Glc
has assertion: cat(p(HGNC:EP300)) -> tport(p(HGNC:KPNA2))
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.976+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:EP300)) -> tport(p(HGNC:KPNA2))
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10801418

6
value: Using an antibody raised against an acetylated Rch1 peptide, we show that Rch1 was acetylated at Lys22 in vivo and that CBP or p300 could mediate this reaction Acetylation of Lys22 promoted interaction with importin-beta in vitro
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10801418

Selventa

RAE-TFJvcSjpAyjgPBI5pBEgdtk7BNWjik12ibdVGF908
has assertion: cat(p(HGNC:F2)) -> bp(GO:"platelet activation")
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.982+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234

cat(p(HGNC:F2)) -> bp(GO:"platelet activation")
had primary source: http://www.ncbi.nlm.nih.gov/pubmed/10801853

4
value: Factor XII deficiency has been postulated to be a risk factor for thrombosis suggesting that factor XII is an antithrombotic protein. The biochemical mechanism leading to this clinical observation is unknown. We have previously reported high molecular weight kininogen (HK) inhibition of thrombin-induced platelet aggregation by binding to the platelet glycoprotein (GP) Ib-IX-V complex. Although factor XII will bind to the intact platelet through GP Ibalpha (glycocalicin) without activation, we now report that factor XIIa (0. 37 microm), but not factor XII zymogen, is required for the inhibition of thrombin-induced platelet aggregation. Factor XIIa had no significant effect on SFLLRN-induced platelet aggregation. Moreover, an antibody to the thrombin site on protease-activated receptor-1 failed to block factor XII binding to platelets. Inhibition of thrombin-induced platelet aggregation was demonstrated with factor XIIa but not with factor XII zymogen or factor XIIf, indicating that the conformational exposure of the heavy chain following proteolytic activation is required for inhibition. However, inactivation of the catalytic activity of factor XIIa did not affect the inhibition of thrombin-induced platelet aggregation. Factor XII showed displacement of biotin-labeled HK (30 nm) binding to gel-filtered platelets and, at concentrations of 50 nm, was able to block 50% of the HK binding, suggesting involvement of the GP Ib complex. Antibodies to GP Ib and GP IX, which inhibited HK binding to platelets, did not block factor XII binding. However, using a biosensor, which monitors protein-protein interactions, both HK and factor XII bind to GP Ibalpha. Factor XII may serve to regulate thrombin binding to the GP Ib receptor by co-localizing with HK, to control the extent of platelet aggregation in vivo.
was quoted from: http://www.ncbi.nlm.nih.gov/pubmed/10801853

Selventa

RAMpf-Cvh7a2iH3-aKayBlcH2nIuO6jaboB-R E8VvlF8
has assertion: assertion
has provenance: provenance
has publication info: pubinfo
type: Nanopublication
created: 2014-07-03T14:29:50.989+02:00
created by: 0000-0001-6818-334X
created by: http://orcid.org/0000-0002-1267-0234