[Mice lacking the Tak1 gene in brain endothelial cells showed a blunted fever response and reduced lethargy upon intravenous injection of the endogenous pyrogen IL-1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

Gene-disease associations manually curated.
DisGeNET evidence - CURATED

[Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Tetrandrine down-regulates ERK/NF-B signaling and inhibits activation of mesangial cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cytokine expression in the muscle of HIV-infected patients: evidence for interleukin-1 alpha accumulation in mitochondria of AZT fibers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effects of Wy14643 on hepatic ischemia reperfusion injury in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORt cells in allergic inflammation, local lung distribution and chemokine gene expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in the calcium-related gene IL1RAPL1 are associated with autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 receptor antagonist halts the progression of established crescentic glomerulonephritis in the rat.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphisms in interleukin 1 beta and interleukin 1 receptor antagonist associated with tumor recurrence in stage II colon cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

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[Interleukin-1 receptor antagonist reduced apoptosis and attenuated intestinal mucositis in a 5-fluorouracil chemotherapy model in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[rhIL-1Ra reduces hepatocellular apoptosis in mice with acetaminophen-induced acute liver failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-1 receptor antagonist modulates the progression of a spontaneously occurring IgA nephropathy in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Six participants showed a favourable course of disease with survival of 25 to 54 months (median 30 months) despite a previous diagnosis of manifest AIDS before IL-2 therapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We studied the effects of human recombinant interleukin-2 (IL-2) on scopolamine-induced amnesia for a passive avoidance response and on scopolamine-induced hyperactivity, in the mouse.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Long-term bone marrow stromal and hemopoietic toxicity to AZT: protective role of heme and IL-1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study compared production of IL-2, IFN-gamma, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Natural-killer-(NK)-cell activity and blood levels of interleukin 2 (IL-2), dehydro-epiandrosterone (DHEA), DHEA sulphate (DHEA-S) and cortisol were measured in 17 patients with major depression and 10 control subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[B cell increases and ex vivo IL-2 production as secondary endpoints for the detection of sensitizers in non-radioisotopic local lymph node assay using flow cytometry.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-2 gene therapy in a patient with glioblastoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A case of superantigen-related glomerulonephritis after methicillin-resistant Staphylococcus aureus (MRSA) infection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Consolidation biochemotherapy for patients with advanced nonsmall cell lung carcinoma responding to induction PVM (cisplatin, vinblastine, mitomycin-C) regimen. A phase II study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel role of triazenes in haematological malignancies: pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-2 (IL-2) is capable of inducing T-lymphocyte cytotoxicity against melanoma in vitro and in vivo.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-2-based biochemotherapy for patients with stage IV melanoma: long-term survivors outside a clinical trial setting.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lymphokine-activated killer (LAK) cells generated by high-dose continuous infusion interleukin-2 (IL-2) are able to nonspecifically lyse melanoma and kidney cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-2-induced antinociception in morphine-insensitive rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Biochemotherapy in patients with advanced vulvovaginal mucosal melanoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We propose that IL-21 exerts a pleiotropic effect in which it promotes the protective effects of CD8+ suppressor cells in the early disease phase and then promotes the humoral components of SLE in the later disease stages.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Through follow-up genotyping of 70 rare and low-frequency protein-altering variants in nine independent case-control series (16,054 Crohn's disease cases, 12,153 ulcerative colitis cases and 17,575 healthy controls), we identified four additional independent risk factors in NOD2, two additional protective variants in IL23R, a highly significant association with a protective splice variant in CARD9 (P < 1 10(-16), odds ratio 0.29) and additional associations with coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ERE-independent ERalpha target genes differentially expressed in human breast tumors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results suggest that IL-27 can be effective in reducing tumor growth and can help enhance accumulation of effector cells in prostate tumors in vivo.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene transcripts as potential diagnostic markers for allergic contact dermatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Liver transcriptional profile of atherosclerosis-related genes in human nonalcoholic fatty liver disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene expression time course in the human skin during elicitation of allergic contact dermatitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IL-33 exacerbates acute kidney injury.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Relationship between gene polymorphism of CYP2E1, CYP1A1, IL-4 and medicamentosa-like dermatitis induced by trichloroethylene].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In contrast to this early anti-inflammatory/immunosuppressive role, during later stages of fibrosis, IL-4 played a profibrotic role since IL-4(-/-) mice developed significantly less pulmonary fibrosis relative to IL-4(+/+) mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Environmental tobacco smoke and interleukin 4 polymorphism (C-589T) gene: environment interaction increases risk of wheezing in African-American infants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Is interleukin-4delta3 splice variant expression in bovine tuberculosis a marker of protective immunity?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells from healthy subjects and allergic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Analysis of effector and regulatory immune reactivity to nickel.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-6 affects scopolamine-induced amnesia, but not brain amino acid levels in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased TNF-alpha and IL6 mRNA expression by alveolar macrophages in chronic beryllium disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increasing percent burn is correlated with increasing inflammation in an adult rodent model.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-6 (IL-6) is overexpressed and contributes to tumor cell growth in cholangiocarcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Furthermore, the level of IL-6, a pleiotropic cytokine which is implicated in the pathogenesis of IBD and colitis-associated cancer, was suppressed by DPhP in rat colon tissue and serum.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Activation of inflammatory response and apoptosis of polymorphonuclear leukocytes in patients with argemone oil poisoning.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A comparative study of the antipyretic effects of indomethacin and dipyrone in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thrombopoietic effects and toxicity of interleukin-6 in patients with ovarian cancer before and after chemotherapy: a multicentric placebo-controlled, randomized phase Ib study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of circulating immune complexes and biocompatibility of staphylococcal protein A immunoadsorption in mitomycin C-induced hemolytic uremic syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The patient had hypercalcaemia associated with increased calcitriol serum levels; circulating interleukin-6 and tumour necrosis factor alpha levels were also elevated.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Notably, these effects could not be blocked by interleukin-6, one of the most important growth factors in multiple myeloma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Table 1 Biochemical Alterations in Substantia Nigra of Parkinson's Disease Indicating Oxidative Stress Elevated Decreased Iron (in microglia, astrocytes, oligodendrocytes, and melanized dopamine neurons and mitochondria) GSH (GSSG unchanged); GSH/GSSG ratio decreased Mitochondrial complex I Ferritin Calcium binding protein (calbindin 28) Mitochondrial monoamine oxidase B Transferrin and transferrin receptor Lipofuscin Vitamins E and C Ubiquitin Copper Cu/Zn-superoxide dismutase Cytotoxic cytokines (TNF-a, IL-1, IL-6) Inflammatory transcription factor NFKB Heme oxygenase-1 Ratio of oxidized to reduced glutathione (GSSG/GSH) Nitric oxide Neuromelanin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Peripartum cardiomyopathy: analysis of clinical outcome, left ventricular function, plasma levels of cytokines and Fas/APO-1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The effects of propofol on neutrophil function, lipid peroxidation and inflammatory response during elective coronary artery bypass grafting in patients with impaired ventricular function.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of interleukin-1 and -6 in the etiopathogenesis of idiopathic osteoporosis and osteopenia in children.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Sulfasalazine inhibits activation of nuclear factor-kappaB in patients with ulcerative colitis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Treatment with a proton pump inhibitor, lansoprazole reduces the mucosal levels of IL-8 mRNA and protein in GERD, including RE and NERD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The aim of this study was to perform a clinical assessment of the association between oral lichenoid reactions (OLR) and amalgam restorations and to determine the salivary concentrations of interleukin-6 (IL-6) and IL-8 before and after replacement of the amalgam restorations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Reciprocal regulation of 17beta-estradiol, interleukin-6 and interleukin-8 during growth and progression of epithelial ovarian cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Autocrine production of interleukin-8 confers cisplatin and paclitaxel resistance in ovarian cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The IL-8 release from cultured human keratinocytes, mediated by antibodies to bullous pemphigoid autoantigen 180, is inhibited by dapsone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene expression in cultured endometrium from women with different outcomes following IVF.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Oxidative stress affects the integrin-linked kinase signaling pathway after transient focal cerebral ischemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Behavioral analysis of the IMPA1-/- mice indicated an increased motor activity in both the open-field test and the forced-swim test as well as a strongly increased sensitivity to pilocarpine-induced seizures, the latter supporting the idea that IMPA1 represents a physiologically relevant target for lithium.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[After validation by Western blot and quantitative real-time PCR, the expressions of three proteins related to neurodegenerative disease, septin 5, -internexin, and -synuclein, were identified to be altered by MCLR exposure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome wide association for addiction: replicated results and comparisons of two analytic approaches.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Exome sequencing supports a de novo mutational paradigm for schizophrenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Carbohydrate metabolism in mania before and after lithium carbonate treatment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We report two ELBW infants who developed hypertrophic cardiomyopathy as an iatrogenic complication of the concurrent therapeutic administration of a glucocorticoid and insulin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Insulin gene mutations as a cause of permanent neonatal diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The data indicate that the effects of streptozotocin-induced diabetes on urinary bladder function are both prevented and reversed by insulin treatment.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Atrial flutter with amoxapine: a case report.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Insulin resistance and type 2 diabetes are associated with elevated circulating levels of insulin, nonesterified fatty acids (NEFAs), and lipoprotein remnants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of liver function in type 2 diabetic patients during clinical trials: evidence that rosiglitazone does not cause hepatic dysfunction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Efficacy of biphasic insulin aspart in patients with type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Individuals with impaired glucose tolerance have increased proinsulin levels, despite normal glucose or C-peptide levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have identified a non-insulin-dependent diabetic patient with fasting hyperinsulinemia (90 microU/ml), an elevated insulin:C-peptide molar ratio (1.68; normal, 0.05-0.20), normal insulin counterregulatory hormone levels, and an adequate response to exogenously administered insulin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Verapamil-induced parkinsonism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Simultaneous side effects of both clozapine and valproate.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Selective proteinuria in diabetic nephropathy in the rat is associated with a relative decrease in glomerular basement membrane heparan sulphate.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Glutathione status, lipid peroxidation and kidney function in streptozotocin diabetic rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[More patients were diagnosed with CHF during the 6 months after rosiglitazone was added to their drug regimens than in the previous 6 months, when these patients received insulin but not rosiglitazone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Although the present data showed a significant reduction in serum zinc and significant rise in plasma insulin in the fatty liver rats there was nonsignificant correlation between the two variables as compared with the normal rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The hemodynamic effects of insulin following overdosage with levobupivacaine or racemic bupivacaine in dogs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Rhabdomyolysis with concurrent atorvastatin and diltiazem.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This method has wide applicability in determining whether hyperproinsulinemia or hyperinsulinemia is the result of defects at the insulin gene, and should permit the detection of new defects at or near this locus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Blurred vision and weakness in a 60-year-old woman.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[When hypertension had been established after 4 weeks of insulin infusion, superimposed infusion of losartan on insulin reversed the elevated BP to control levels within 1 week.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The purpose of these studies was, first, to determine whether hypertonic saline (HS) infusion or nitroprusside (NiPr)-induced hypotension augments the vasopressin (AVP) and adrenocorticotropic hormone (ACTH) responses to insulin (Ins)-induced hypoglycemia and, second, to determine whether neurohypophysectomy could attenuate the augmentation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Insulin-induced weakness in hypokalemic myopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evaluation of apoptosis and cell proliferation in experimentally induced renal cysts.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Insulin resistance, which is central to the metabolic syndrome and type 2 diabetes mellitus, leads to high levels of very low-density lipoprotein (VLDL), which contain a high concentration of triglycerides, resulting in high serum triglyceride levels and low serum HDL-C levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Anthropometric variables and metabolism in polycystic ovarian disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Anxiogenic effects of the CCK(B) agonist pentagastrin in humans and dose-dependent increase in plasma C-peptide levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism of the insulin gene is associated with increased prostate cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Losartan-induced azotemia in a diabetic recipient of a kidney transplant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Postoperative ventricular arrhythmias caused by isoproterenol. Conversion with insulin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effects of angiotensin II on insulin receptor binding and mRNA levels in normal and diabetic rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To our knowledge, the present study is the first to demonstrate that impaired peripheral nerve IR signaling, as indicated by decreased phosphorylated:total IR protein ratio, coincides with early mechanical hyperalgesia and thermal hypoalgesia in STZ-diabetic rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We report on a 13-year-old girl with Donohue syndrome like dysmorphism, hyperinsulinism and prolonged survival due to two novel INSR missense mutations within the insulin binding domain.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mice deficient for Irf6 have not been reported, but in humans, mutations in IRF6 cause two mendelian orofacial clefting syndromes, and genetic variation in IRF6 confers risk for isolated cleft lip and palate.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Novel mutations in the IRF6 gene in Brazilian families with Van der Woude syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We identified a common, 20-kb deletion polymorphism, immediately upstream of IRGM and in perfect linkage disequilibrium (r2 = 1.0) with the most strongly CD-associated SNP, that causes IRGM to segregate in the population with two distinct upstream sequences.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Human insulin receptor substrate-1 (hIRS-1) cDNAs were cloned from a lambda GT11 expression library using a monoclonal antibody (MAb) produced against a human hepatocellular carcinoma (HCC) cell line (FOCUS).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Besides the increased frequency of diabetes, carriers showed a more atherogenic lipid profile, suggesting a potential role of the IRS-1 gene in the pathogenesis of lipid abnormalities associated with CAD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Expression of Iroquois genes is up-regulated during early lung development in the nitrofen-induced pulmonary hypoplasia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Here we report mutations in the ISPD gene (encoding isoprenoid synthase domain containing) as the second most common cause of WWS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Distribution of alpha and beta integrin subunits in the adult rat hippocampus after pilocarpine-induced neuronal cell loss, axonal reorganization and reactive astrogliosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Quantitative expression of the homeobox and integrin genes in human gastric carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effect of anti-CD11b (alphaM-MAC-1) and anti-CD54 (ICAM-1) monoclonal antibodies on indomethacin induced chronic ileitis in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[beta2 Integrins are characteristically absent in acute promyelocytic leukemia and rapidly upregulated in vivo upon differentiation with all-trans retinoic acid.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Spontaneous skin ulceration and defective T cell function in CD18 null mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Glycoprotein IIIA gene (PlA) polymorphism and aspirin resistance: is there any correlation?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Sra, a private platelet antigen on glycoprotein IIIa associated with neonatal alloimmune thrombocytopenia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Missense mutations in ITPR1 cause autosomal dominant congenital nonprogressive spinocerebellar ataxia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Microarray comparison of prostate tumor gene expression in African-American and Caucasian American males: a pilot project study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in the human Jagged1 gene are responsible for Alagille syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[All four mutations lie within conserved regions of the gene and cause translational frameshifts, resulting in gross alterations of the protein product Patients with cytogenetically detectable deletions including JAG1 have Alagille syndrome, supporting the hypothesis that haploinsufficiency for this gene is one of the mechanisms causing the Alagille syndrome phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Limited efficacy of hydroxyurea in lowering of the JAK2 V617F allele burden.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Given that the identical somatic activating mutation in the JAK2 tyrosine kinase gene (JAK2(V617F)) is observed in most individuals with polycythemia vera, essential thrombocythemia and primary myelofibrosis, there likely are additional genetic events that contribute to the pathogenesis of these phenotypically distinct disorders.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A somatic point mutation that causes a constitutive activation of the JAK2 gene is found in one in two ET patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The frequency of V617F was 65 percent among patients with polycythemia vera (83 of 128), 57 percent among patients with idiopathic myelofibrosis (13 of 23), and 23 percent among patients with essential thrombocythemia (21 of 93).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Global analysis of differentially expressed genes in androgen-independent prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A single point mutation (Val617Phe) was identified in JAK2 in 71 (97%) of 73 patients with polycythaemia vera, 29 (57%) of 51 with essential thrombocythaemia, and eight (50%) of 16 with idiopathic myelofibrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Primary thrombocythemia: diagnosis and therapy].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Systematic sequencing of the coding region of the extended JRK/JH8 gene identified single nucleotide polymorphisms that define three haplotypes, which were used for association studies in patients with idiopathic generalized epilepsy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The mutational landscape of adenoid cystic carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We show that haploinsufficiency of KANSL1 is sufficient to cause the 17q21.31 microdeletion syndrome, a multisystem disorder characterized by intellectual disability, hypotonia and distinctive facial features.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in KANSL1 cause the 17q21.31 microdeletion syndrome phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effect of phenylephrine provocation on dispersion of repolarization in congenital long QT syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Correlation of HERG K+ channel protein expression to chemosensitivity of tumor cells to doxorubicin and its modulation by erythromycin].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We previously mapped LQT loci on chromosomes 11 (LQT1), 7 (LQT2), and 3 (LQT3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations of another voltage-gated chloride channel, CLC-Kb, are associated with a form of Bartter's syndrome, whereas other forms of Bartter's syndrome are caused by mutations in the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC2) and the potassium channel, ROMK.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hyperinsulinism of infancy: novel ABCC8 and KCNJ11 mutations and evidence for additional locus heterogeneity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Ventricular fibrillation with prominent early repolarization associated with a rare variant of KCNJ8/KATP channel.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We have identified KCNMA1 as a new susceptibility locus for obesity, and confirmed the association of the BDNF locus at the genome-wide significant level.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To determine whether the neonatal mouse can serve as a useful model for studying the molecular pharmacological basis of Long QT Syndrome Type 1 (LQT1), which has been linked to mutations in the human KCNQ1 gene, we measured QT intervals from electrocardiogram (ECG) recordings of wild-type (WT) and Kcnq1 knockout (KO) neonates before and after injection with the beta-adrenergic receptor agonist, isoproterenol (0.17 mg/kg, i.p.).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[(-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thiram-induced changes in the expression of genes relating to vascularization and tibial dyschondroplasia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Direct evidence that mutation of the KHK structural gene is the cause of essential fructosuria was also obtained.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Craniofacial development in the talpid3 chicken mutant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Here we report mutations in KIF7 in individuals with hydrolethalus and acrocallosal syndromes, two multiple malformation disorders with overlapping features that include polydactyly, brain abnormalities and cleft palate.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[KiSS1 mediates platinum sensitivity and metastasis suppression in head and neck squamous cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In vivo efficacy of STI571 in xenografted human small cell lung cancer alone or combined with chemotherapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genome-wide association study of testicular germ cell tumor.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Molecular evidence for differences in endometrium in severe versus mild endometriosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Substance dependence low-density whole genome association study in two distinct American populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[This study investigates gene therapy with human tissue kallikrein as a treatment for fructose-induced hypertension in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The human kallikrein 10 promoter contains a functional retinoid response element.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Human glandular kallikrein, which is encoded by the human kallikrein-2 (KLK2) gene, is significantly associated with the occurrence of prostate cancer (PCa).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Profiling genetic variation along the androgen biosynthesis and metabolism pathways implicates several single nucleotide polymorphisms and their combinations as prostate cancer risk factors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Randomized Phase II study comparing paclitaxel and carboplatin versus mitoxantrone in patients with hormone-refractory prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple newly identified loci associated with prostate cancer susceptibility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Low expression of CD161 and NKG2D activating NK receptor is associated with impaired NK cell cytotoxicity in metastatic melanoma patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Bradykinin is believed to be the main mediator of symptoms in hereditary (HA) and acquired (AA) angio-oedema due to C1 esterase inhibitor deficiency, as well as in angio-oedema that complicates treatment with inhibitors of angiotensin-converting enzyme (ACE).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cardiac arrhythmias are ameliorated by local inhibition of angiotensin formation and bradykinin degradation with the converting-enzyme inhibitor ramipril.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pharmacological evaluation of 1-(carboxymethyl)-3,5-diphenyl-2-methylbenzene, a novel arylacetic acid with potential anti-inflammatory properties.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In addition, the ME of B. microstachya (3--300 mg kg(-1), i.p., 30 min earlier) inhibited, in a graded manner, the hyperalgesia induced by bradykinin (3.2 microg/paw), substance P (13.5 microg/paw), carrageenan (300 microg/paw), capsaicin (100 microg/paw) and adrenaline (100 ng/paw) in the rat paw, with mean ID50 values of 20.5, 17.9, 101.8, 54.2 and 99.7 mg kg(-1), respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In addition, amyrin octanoate reduced thermal and mechanical hyperalgesia induced by bradykinin and phorbol myristate acetate in rats, without affecting similar responses caused by prostaglandin E(2).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Specific prostaglandins have been identified that mediate the sympathetic postganglionic neuron-terminal dependent hyperalgesia induced by bradykinin and norepinephrine, prostaglandin E2 and prostacyclin, respectively.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of bradykinin in acid-induced mesenteric hyperemia and duodenal villous damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cardioprotective effects by ramipril after ischemia and reperfusion in animal experiment studies].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Selective reduction of second pain sensations by systemic morphine in humans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[ras p21 Isoprenylation inhibition induces flat colon tumors in Wistar rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Benzo[b]fluoranthene: tumorigenicity in strain A/J mouse lungs, DNA adducts and mutations in the Ki-ras oncogene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Changes in eutopic endometrial gene expression during the progression of experimental endometriosis in the baboon, Papio anubis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Final report on carcinogens background document for riddelliine.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2',3'-dideoxycytidine-induced lymphomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The role of induction (neoadjuvant) chemotherapy in stage IIIA NSCLC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Among these identified proteins, 33 proteins including keratin 17 (KRT17), biliverdin reductase B (BLVRB), proteasome activator subunit 1 (PSME1), manganese superoxide dismutase (MnSOD), high-mobility group box-1(HMGB1), heat shock protein 70 (HSP70), peroxiredoxin (PRDX1), keratin 13 (KRT13), and so on were overexpressed, and 14 proteins including cystatin B (CSTB), tropomyosin 2 (TPM2), annexin 1 (ANX1), transgelin (TAGLN), keratin 19 (KRT19), stratifin (SFN), and so on were down-expressed in ESCC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Abnormal expression of MAPK, EGFR, CK17 and TGk in the skin lesions of chloracne patients exposed to dioxins.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Expression of cytokeratins 8 and 18 on Mallory body and oval cell in rats during hepatic fibrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Presence of K8/K18 variants predisposes to adverse ALF outcome, and some variants segregate with unique ethnic and race backgrounds.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[New common variants affecting susceptibility to basal cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[KRT8 and KRT18 are important susceptibility genes for ALF development.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hepatocellular carcinoma-associated protein markers investigated by MALDI-TOF MS.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Since it has been shown that X-linked hydrocephalus can be caused by mutations in L1CAM, a neuronal cell adhesion molecule, we performed an L1CAM mutation analysis in eight unrelated patients with MASA syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Vitamin E inhibits activated chaperone-mediated autophagy in rats with status epilepticus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Similarly, LBP concentrations were higher in individuals with metabolic syndrome than in individuals without it (P<0.001).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Repeat oral dose toxicity studies of melamine in rats and monkeys.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A missense mutation found in human lactate dehydrogenase-B (H) variant gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mangifera indica L. extract (Vimang) and its main polyphenol mangiferin prevent mitochondrial oxidative stress in atherosclerosis-prone hypercholesterolemic mouse.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Aspirin resistance with genetic dyslipidemia: contribution of vascular thromboxane generation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cardioprotective effects of a proanthocyanidin-rich fraction from Croton celtidifolius Baill: focus on atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Low density lipoprotein receptor deficient (LDLR-KO) and apolipoprotein E deficient (apo E-KO) mice both develop hyperlipidemia and atherosclerosis by different mechanisms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A `de novo` mutation of the LDL-receptor gene as the cause of familial hypercholesterolemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[mRNA levels for 3-hydroxy-3-methylglutaryl-coenzyme A reductase decreased in hyperplasia and increased in HCC, whereas low-density lipoprotein receptor mRNA increased in hyperplasia and decreased in HCC.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Human sebaceous tumors harbor inactivating mutations in LEF1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In this study, we determined the effect of high cholesterol diet and 27-OHC on leptin expression levels and the extent to which leptin treatment affects 27-OHC-induced AD-like pathology.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The results of immunohistochemistry, Western blotting and semiquantitative RT-PCR indicated that mRNA and protein levels of leptin, leptin receptors, androgen receptor and FGF2 were significantly higher in the GDM placentae than non-GDM placentae; while NRIH3, NRIH2, StARD3, CYP11A1, HSD3B, HSD11B, HSD17B, ERalpha, ERbeta, progesterone receptor, FGF receptor-2, insulin receptor-alpha and -beta showed no differences.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Insulin depletion leads to adipose-specific cell death in obese but not lean mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To measure serum leptin levels and compare them in lean and obese subjects and to identify correlation between serum leptin levels, heart rate and hypertension in lean and obese subjects among adult females.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These data suggested that sex steroid converting enzymes expression was different in SAT of PCOS patients that might contribute to abnormal testosterone and leptin level of PCOS patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Leptin receptor-deficient mice (db/db mice) are more vulnerable to seizure-induced hippocampal damage, and intraventricular administration of leptin protects neurons against seizures.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Involvement of capsaicin-sensitive afferent nerves and cholecystokinin 2/gastrin receptors in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Impaired cardiac functional reserve in type 2 diabetic db/db mice is associated with metabolic, but not structural, remodelling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Neuropeptidergic characterization of the leptin receptor mutated obese Koletsky rat.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Estrone treatment dissociates primary versus secondary consequences of `diabetes` (db) gene expression in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Congenital leptin-receptor deficiency should be considered in the differential diagnosis in any child with hyperphagia and severe obesity in the absence of developmental delay or dysmorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The present study presents information about a possible function for LETM1 and suggests that at least some (neuromuscular) features of WHS may be caused by mitochondrial dysfunction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Low expression of Bax predicts poor prognosis in patients with locally advanced esophageal cancer treated with definitive chemoradiotherapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genomic and epigenomic integration identifies a prognostic signature in colon cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Cryptic 17q22 deletion in a boy with a t(10;17)(p15.3;q22) translocation, multiple synostosis syndrome 1, and hypogonadotropic hypogonadism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hypogonadism in a patient with a mutation in the luteinizing hormone beta-subunit gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Endocrinology of male infertility.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Progesterone is essential for protecting against LPS-induced pregnancy loss. LIF as a potential mediator of the anti-inflammatory effect of progesterone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Development of the mammalian female reproductive tract.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The Stve-Wiedemann Syndrome (SWS) is a frequently lethal chondrodysplasia caused by null mutations in the leukemia inhibitory factor receptor gene (LIFR) responsible for an impaired activation of the JAK-STAT pathway after LIF stimulation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The G-250A substitution in the promoter region of the hepatic lipase gene is associated with the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Tight skin and limited joint movements as early presentation of Hutchinson-Gilford progeria in a 7-week-old infant.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Familial progressive sinoatrial and atrioventricular conduction disease of adult onset with sudden death, dilated cardiomyopathy, and brachydactyly. A new type of heart-hand syndrome?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Response to treatment with rosiglitazone in familial partial lipodystrophy due to a mutation in the LMNA gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Compound heterozygosity for mutations in LMNA in a patient with a myopathic and lipodystrophic mandibuloacral dysplasia type A phenotype.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Identification of lamin A/C ( LMNA) gene mutations in Korean patients with autosomal dominant Emery-Dreifuss muscular dystrophy and limb-girdle muscular dystrophy 1B.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The clinical diagnosis of nail-patella syndrome was confirmed by demonstrating a splice mutation in the intron 5 (750 + 1 G>A) of the LMX1B gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Usefulness of carvedilol in the treatment of chronic aortic valve regurgitation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Oral submucous fibrosis: review on aetiology and pathogenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Elevated plasma levels of the lipoprotein Lp(a) are associated with increased risk for atherosclerosis and its manifestations, myocardial infarction, stroke and restenosis (for reviews, see refs 1-3).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Hyperlipidemia and increased serum lipoprotein (Lp)(a) are independent risk factors for atherosclerosis and its complications.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Polymorphism in the apolipoprotein(a) gene, plasma lipoprotein(a), cardiovascular disease, and low-dose aspirin therapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Comparison of forearm endothelial function between premenopausal and postmenopausal women with or without hypercholesterolemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lipoprotein (a): its role in childhood thromboembolism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Lipolysis is an important determinant of isoproterenol-induced myocardial necrosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effects of treatment with bezafibrate on lipoprotein lipase activity and mass in patients with hypertriglyceridemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Variations in DNA elucidate molecular networks that cause disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Among the total twelve genes, six genes were strongly up- (MT-3, ACAT1, clusterin and ApoE) or down- (ZnT-1 and PRG-3) regulated by developmental seizures (EXP1) compared with that in the CONT1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Various mutations in leucine-rich repeat kinase 2 (LRRK2) have been linked to susceptibility for both familial and idiopathic late-onset Parkinson's disease (PD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We report that adult neurogenesis is highly susceptible to multiple `risk factors` for PD, including -synuclein accumulation, LRRK2 G2019 mutation and exposure to environmental toxins.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Seven cDNAs enriched following hippocampal lesion: possible roles in neuronal responses to injury.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association study identifies five new breast cancer susceptibility loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Therapeutic potential of iron chelators in diseases associated with iron mismanagement.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Liposomalization of lactoferrin enhanced it's anti-inflammatory effects via oral administration.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[To further support the above results, the expression of TLR4, MD-2, and CXCR7 was analyzed in human colorectal carcinoma tissues.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Chromosomal translocation involving the beta T cell receptor gene in acute leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MAGE-A9 mRNA and protein expression in bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[New insights into the pathogenesis of cystic follicles in cattle: microarray analysis of gene expression in granulosa cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Platelet monoamine oxidase activity in megaloblastic anaemia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Increased baroreceptor response in mice deficient in monoamine oxidase A and B.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Screening a larger cohort of individuals with melanoma revealed the presence of recurring somatic MAP2K1 and MAP2K2 mutations, which occurred at an overall frequency of 8%.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association for methamphetamine dependence: convergent results from 2 samples.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Meta-analysis identifies common variants associated with body mass index in east Asians.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Tamoxifen neuroprotection in cerebral ischemia involves attenuation of kinase activation and superoxide production and potentiation of mitochondrial superoxide dismutase.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Knockout of ERK1 enhances cocaine-evoked immediate early gene expression and behavioral plasticity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These results indicate increased activity of TNF-alpha and MAPK following sepsis and demonstrate the beneficial effect of CMT-3 in preventing the increase in TNF-alpha, p38 MAPK, p42/44 MAPK, and the progression of septic shock.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone-induced morphine withdrawal.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Critical role of aquaporin 3 on growth of human esophageal and oral squamous cell carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Vanadium increases GLUT4 in diabetic rat skeletal muscle.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Exogenously-added copper/zinc superoxide dismutase rescues damage of endothelial cells from lethal irradiation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-B in 4-nitroquinoline 1-oxide-induced murine oral cancer model.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[c-Jun terminal kinase-2 gene deleted mice overexpress hemeoxygenase-1 and are protected from hepatic ischemia reperfusion injury.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These studies identify JNK2 as a tumor and host target to inhibit breast cancer growth and metastasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in microtubule associated protein tau (MAPT) are detected in approximately 30% of familial FTD kindreds.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These hereditary disorders are known collectively as frontotemporal dementia (FTD) and parkinsonism linked to chromosome 17 (FTDP-17).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thirteen families have been described with an autosomal dominantly inherited dementia named frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), historically termed Pick's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder characterized by aggregates of the microtubule-associated protein tau (MAPT).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Inherited deficiency of mannan-binding lectin-associated serine protease 2.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our findings demonstrate that isolated persistent hypermethioninemia is a marker of MAT I/III deficiency, and that complete lack of MAT I/III activity can lead to neurological abnormalities.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mannose-binding lectin gene polymorphisms are associated with gestational diabetes mellitus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mannose binding protein gene mutations associated with unusual and severe infections in adults.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Evidence for an association between mannose-binding lectin 2 (MBL2) gene polymorphisms and pre-term birth.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Effects of amphetamine and cocaine on the development of acute experimental allergic encephalomyelitis in Lewis rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Functional adrenocorticotropic hormone receptor in cultured human vascular endothelial cells : possible role in control of blood pressure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Thus, studies that combine clinical screening of obese patients and investigation of the functional defects of the obesity-linked MC4R variants can identify specific ways to correct these defects and are the first steps towards personalized medicine.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in the melanocortin-4 receptor (MC4R) are associated with early-onset obesity in humans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mcl-1 is a novel therapeutic target for human sarcoma: synergistic inhibition of human sarcoma xenotransplants by a combination of mcl-1 antisense oligonucleotides with low-dose cyclophosphamide.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Abnormal lysosomes and mitochondria are common features of the human lysosomal storage disorder known as mucolipidosis IV (MLIV).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We previously demonstrated that midkine-deficient (Mdk(-/-)) mice exhibited a delayed hippocampal development with impaired working memory and increased anxiety only at the age of 4 weeks.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Altogether, our findings identify Mdk as a pivotal factor involved in the resistance of glioma cells to THC pro-autophagic and antitumoral action, and suggest that selective targeting of the Mdk/ALK axis could help to improve the efficacy of antitumoral therapies for gliomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Here, we demonstrate that HDMX regulates p53 to promote GBM growth and attenuates tumor response to chemotherapy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MECP2 structural and 3'-UTR variants in schizophrenia, autism and other psychiatric diseases: a possible association with autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Here we report on a male infant with neonatal encephalopathy, myoclonic jerks, and irregular breathing patterns caused by a novel frameshift mutation in the MECP2 gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[These include the identification of many MeCP2 target genes, better understanding of the neurobiological consequences of the loss- or mis-function of MeCP2, and drug testing in RTT mice and clinical trials in human RTT patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Autonomic dysfunction with mutations in the gene that encodes methyl-CpG-binding protein 2: insights into Rett syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Males with MECP2 mutations present with a broad spectrum of phenotypes ranging from neonatal encephalopathy to nonsyndromic mental retardation (MR).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[We evaluated 226 autistic individuals for alterations in the four genes most homologous to MECP2: MBD1, MBD2, MBD3, and MBD4.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Mer receptor tyrosine kinase signaling participates in platelet function.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[In conclusion, patients with calcific AVD had significantly lower levels of circulating ucMGP as compared to a reference population, free of coronary and valvular calcifications.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Within this locus, we isolated a complete cDNA of a novel gene, designated myocardial infarction associated transcript (MIAT).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Antagonizing MIF's activity with a systemic MIF tautomerase inhibitor was able to prevent or greatly reduced chemical cystitis in mice, thus indicating the MIF mediates bladder inflammation in this model.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MicroRNAs reduce tumor growth and contribute to enhance cytotoxicity induced by gefitinib in non-small cell lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Association of MiR-126 with soluble mesothelin-related peptides, a marker for malignant mesothelioma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[miR-24-2 controls H2AFX expression regardless of gene copy number alteration and induces apoptosis by targeting antiapoptotic gene BCL-2: a potential for therapeutic intervention.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Germline deletion of the miR-1792 cluster causes skeletal and growth defects in humans.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and -tocotrienol.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Striatal microRNA controls cocaine intake through CREB signalling.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Prognostic and predictive value of changes in tumour cell proliferation in locally advanced breast cancer primarily treated with doxorubicin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Correlation of Ki-67, p53, and Adnab-9 immunohistochemical staining and ploidy with clinical and histopathologic features of severely dysplastic colorectal adenomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Our results strengthen the case for a more detailed study of the role of RELN and GRIK2 in autism susceptibility, as well as identifying two new potential candidate genes, MKL2 and SND1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.

[Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Mutation screening of mismatch repair gene Mlh3 in familial esophageal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Common variation at 10p12.31 near MLLT10 influences meningioma risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[CRF resulted in hypertension, proteinuria, renal tissue lipid accumulation, up-regulation of scavenger receptor A1 (SR-A1), acyl-CoA cholesterol acyltransferase-1 (ACAT1), carbohydrate-responsive element binding protein (ChREBP), fatty acid synthase (FAS), acyl-CoA carboxylase (ACC), liver X receptor (LXR), ATP binding cassette (ABC) A-1, ABCG-1, and SR-B1 and down-regulation of sterol responsive element binding protein-1 (SREBP-1), SREBP-2, HMG-CoA reductase, PPAR-alpha, fatty acid binding protein (L-FABP), and CPT1A.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Down regulation of kidney neutral endopeptidase mRNA, protein and activity during acute renal failure: possible mechanism for ischemia-induced acute renal failure in rats?]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Treatment of sheep steroid-induced ocular hypertension with a glucocorticoid-inducible MMP1 gene therapy virus.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Regulation of matrix metalloproteinase 13 expression by androgen in prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Using a newly developed chimeric mouse model of AAA, we now demonstrate that macrophage-derived MT1-MMP plays a dominant role in disease progression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The matrix metalloproteinases (MMPs) contribute to cardiovascular remodeling, and MMPs, such as the gelatinases (MMP-9 and MMP-2), have been identified in thoracic aortic aneurysmal (TAA) tissue, but a cause-effect relationship has not been clearly established.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The median MMP-2 and MMP-9 pretreatment levels were more elevated in BMTS as compared to HS (p < or = 0.0001).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Evidence of early involvement of matrix metalloproteinase-2 in lead-induced hypertension.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Heparanase expression during normal liver development and following partial hepatectomy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Bisphosphonate-induced osteonecrosis of the jaws, bone markers, and a hypothesized candidate gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[S-Adenosylhomocysteine promotes the invasion of C6 glioma cells via increased secretion of matrix metalloproteinase-2 in murine microglial BV2 cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[In this study, we examined the sequential expression of MMP-2, MMP-9 and TIMP-1 in a rat model of pulmonary fibrosis induced by PQ.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[In the present study, we found that glycitein, a bacterial metabolite of the isoflavone glycitin, inhibits the expression of MMP-3 and MMP-9 at promoter, mRNA, and protein levels in PMA-stimulated U87MG human astroglioma cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Wound healing in ovariectomized rats: effects of chemically modified tetracycline (CMT-8) and estrogen on matrix metalloproteinases -8, -13 and type I collagen expression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[PGE2 and MMP-9 are elevated in aortic aneurysms.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Our results also show that treatment of U87MG cells with the two isoflavones induced decreases in the enzymatic activity of MMP-9 and the protein levels of MT1-MMP and uPAR.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Altered redox status accompanies progression to metastatic human bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[It was found that MMP-9 in oral fluid could be considered as a marker of chronic generalized periodontitis irrespective of the presence or absence of metal dental restorations.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Expression profiling and identification of novel genes in hepatocellular carcinomas.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Primary and secondary thrombocytosis in childhood.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Protective role of cyclooxygenase (COX) inhibitors in burn-induced intestinal and liver damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Milano summer particulate matter (PM10) triggers lung inflammation and extra pulmonary adverse events in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[On stratified analysis, we found the MPO genotypes modified the effect of asbestos exposure on lung cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Within the AIU groups, significant correlations were noted between the levels of MPO and IL-8, and IL-8 and IL-18.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Heterozygous P0 deficiency protects mice from vincristine-induced polyneuropathy.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[An integrative approach to identify YB-1-interacting proteins required for cisplatin resistance in MCF7 and MDA-MB-231 breast cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genetic and ethnic risk factors associated with drug hypersensitivity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Expression of xeroderma pigmentosum complementation group C protein predicts cisplatin resistance in lung adenocarcinoma patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[It has been reported that serum concentrations of megakaryocyte potentiating factor N-ERC/mesothelin become elevated in patients with mesotheliomas caused by asbestos exposure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genome-wide association identifies multiple ulcerative colitis susceptibility loci.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Myocardial myostatin mRNA and protein expression were up-regulated in the rat model of volume-overload heart failure.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Malleal processus brevis is dispensable for normal hearing in mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Metallothionein-1 and -2 expression in cadmium- or arsenic-derived human malignant urothelial cells and tumor heterotransplants and as a prognostic indicator in human bladder cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Modulation of cytochrome C oxidase-va is possibly involved in metallothionein protection from doxorubicin cardiotoxicity.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Metallothionein isoform II expression in hyperplastic, dysplastic and neoplastic prostatic lesions.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Metallothionein is up-regulated under hypoxia and promotes the survival of human prostate cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Differential induction of Mn-containing superoxide dismutase by paraquat in peripheral lymphocytes of normal subjects and gastric cancer patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Warfarin-induced hemorrhagic pseudocyst in the pelvis of a woman with an inherited disorder of blood coagulation, complicated by pelvic bone pseudoxanthoma mimicking Erdheim-Chester disease].]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Using a case-parent-triad design, the authors investigated whether the MTHFR C677T polymorphism, and maternal periconceptional folic acid supplement use, influenced risk of isolated clubfoot.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[677TT polymorphism of methylenetetrahydrofolate reductase in combination with low serum vitamin B12 is associated with coronary in-stent restenosis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The impact of the MTHFR polymorphism on stroke may result from T allele-linked deleterious effects, or C allele-linked protection.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Re: folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[MTX-induced white matter changes are associated with polymorphisms of methionine metabolism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[The role of C677T/MTHFR and A2756G/MTR on chemotherapy-induced toxicity should be further investigated in pediatric osteosarcomas receiving high-dose methotrexate.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[In humans, severe hyperhomocysteinemia due to genetic alterations in cystathionine beta-synthase (Cbs) or methylenetetrahydrofolate reductase (Mthfr) results in neurological abnormalities and premature death from vascular complications.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Splenic thrombosis in three patients with moderate hyperhomocysteinemia, low folate and the C677T variant of the methylenetetrahydrofolate reductase (MTHFR) gene.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Genetic polymorphism of folate and methionine metabolizing enzymes and their susceptibility to malignant lymphoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: association with toxicity and survival.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Cerebral sinus venous thrombosis in a subject with thyrotoxicosis and MTHFR gene polymorphism.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Folate pathway and nonsyndromic cleft lip and palate.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
[We hypothesized that mammalian target of rapamycin (mTOR) is activated in MCL and contributes to tumor proliferation and survival.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.