3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL [drugbank:DB07335]

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. [PubChem]
Naloxone
Naloxone [drugbank:DB01183]

3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine
3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine [drugbank:DB07525]

Ferricrocin-Iron
Ferricrocin-Iron [drugbank:DB03574]

8-Demethyl-8-Dimethylamino-Flavin-Adenine-Dinucleotide
8-Demethyl-8-Dimethylamino-Flavin-Adenine-Dinucleotide [drugbank:DB03482]

Magnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents.
Magnesium
Magnesium [drugbank:DB01378]

Long-acting, broad-spectrum, water-soluble, cephalexin derivative. [PubChem]
Cefadroxil
Cefadroxil [drugbank:DB01140]

(2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
(2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID [drugbank:DB07979]

Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse potential, although little more information is available.
Dimethylthiambutene
Dimethylthiambutene [drugbank:DB01444]

Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase. [PubChem]
Clavulanate
Clavulanate [drugbank:DB00766]

Synthetic peptide, 32 residues long formulated as a nasal spray.
Salmon Calcitonin
Salmon Calcitonin [drugbank:DB00017]

Cardioactive derivative of lanatoside A or of digitoxin used for fast digitalization in congestive heart failure.
Acetyldigitoxin
Acetyldigitoxin [drugbank:DB00511]

Heparin Disaccharide I-S
Heparin Disaccharide I-S [drugbank:DB02322]

Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.
Chloroxine
Chloroxine [drugbank:DB01243]

1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea
1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea [drugbank:DB07361]

Bombykol
Bombykol [drugbank:DB02982]

Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. It is used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Halobetasol Propionate
Halobetasol Propionate [drugbank:DB00596]

Fulvestrant is a drug treatment of hormone receptor-positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.
Fulvestrant
Fulvestrant [drugbank:DB00947]

A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. [PubChem]
Desogestrel
Desogestrel [drugbank:DB00304]

trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium
trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium [drugbank:DB07330]

N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide [drugbank:DB07537]

Menotropins contains follicle stimulating hormone (FSH) and luteinizing hormone (LH) purified from the urine of postmenopausal women. It is used as a fertility medication that is injected either subcutaneously or intramuscularly. It is composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues.
Menotropins
Menotropins [drugbank:DB00032]

3-[2-bromo-4-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-methylbenzonitrile
3-[2-bromo-4-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-methylbenzonitrile [drugbank:DB08444]

1,4-Deoxy-1,4-Dithio-Beta-D-Glucopyranose
1,4-Deoxy-1,4-Dithio-Beta-D-Glucopyranose [drugbank:DB03857]

2-AMINO-3-(1-HYDROPEROXY-1H-INDOL-3-YL)PROPAN-1-OL
2-AMINO-3-(1-HYDROPEROXY-1H-INDOL-3-YL)PROPAN-1-OL [drugbank:DB08638]

CRA_10762 [drugbank:DB02366]

2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers. Preclinical models also suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. [Wikipedia]
2-Methoxyestradiol
2-Methoxyestradiol [drugbank:DB02342]

Acamprosate, also known by the brand name Campral™, is a drug used for treating alcohol dependence. Acamprosate is thought to stabilize the chemical balance in the brain that would otherwise be disrupted by alcoholism, possibly by blocking glutaminergic N-methyl-D-aspartate receptors, while gamma-aminobutyric acid type A receptors are activated. Reports indicate that acamprosate only works with a combination of attending support groups and abstinence from alcohol. Certain serious side effects include allergic reactions, irregular heartbeats, and low or high blood pressure, while less serious side effects include headaches, insomnia, and impotence. Acamprosate should not be taken by people with kidney problems or allergies to the drug.
Acamprosate
Acamprosate [drugbank:DB00659]

(S)-blebbistatin
(S)-blebbistatin [drugbank:DB01944]

2,6-dibromo-4-[(E)-2-phenylethenyl]phenol
2,6-dibromo-4-[(E)-2-phenylethenyl]phenol [drugbank:DB08101]

N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID [drugbank:DB07816]

2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER
2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER [drugbank:DB07366]

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [PubChem]
Etoposide
Etoposide [drugbank:DB00773]

Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes.
Stanozolol
Stanozolol [drugbank:DB06718]

6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE [drugbank:DB07444]

NP-50301 is an ophthalmic therapeutic eye drop treating post-menopausal Dry Eye Syndrome (DES). It is being developed by Nascent Pharmaceuticals. It is estimated that about 30% of postmenopausal women suffer symptoms of DES, which accounts for over 12 million women in the U.S. The majority of sufferers of DES are postmenopausal women; and clinical research around the world has suggested the benefits of both topical and systemic estrogen therapy in the treatment of DES in this population.
NP-50301 [drugbank:DB05662]

Obinutuzumab is a humanized monoclonal antibody used as a combination treatment with chlorambucil to treat patients with untreated chronic lymphocytic leukemia. It was approved by the FDA in November 2013 and is marketed under the brand name Gazyva. There is a black box warning of fatal Hepatitis B Virus (HBV) reactivation and fatal Progressive Multifocal Leukoencephalopathy (PML).
Obinutuzumab
Obinutuzumab [drugbank:DB08935]

Allyl-{6-[3-(4-Bromo-Phenyl)-Benzofuran-6-Yloxy]-Hexyl-}-Methyl-Amin
Allyl-{6-[3-(4-Bromo-Phenyl)-Benzofuran-6-Yloxy]-Hexyl-}-Methyl-Amin [drugbank:DB02339]

7n-Methyl-8-Hydroguanosine-5'-Triphosphate
7n-Methyl-8-Hydroguanosine-5'-Triphosphate [drugbank:DB03358]

Cellotetraose
Cellotetraose [drugbank:DB02717]

PCL-016 or Picolinic acid drug substance is a pyridine carboxylate metabolite of tryptophan. It acts as an anti-infective and immunomodulator and is produced in approximately 25-50 mg quantities by the body on a daily basis through the breakdown of tryptophan. PCL-016 plays a key role in zinc transport. As a therapeutic agent, the molecule works by binding to zinc finger proteins (ZFPs) in a way that changes their structures and disrupts zinc binding, inhibiting function. ZFPs are involved in viral replication and packaging as well as normal cell homeostatic functions. Picolinic acid has been shown to be an anti-viral in vitro and in vivo, and sometimes works in conjunction with other cytokines such as interferon gamma to affect immune responses. Acne vulgaris, herpes and other viral infections therefore pose potential therapeutic targets of PCL-016.
PCL-016
PCL-016 [drugbank:DB05483]

Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.
Cycrimine
Cycrimine [drugbank:DB00942]

OT-551 is a novel small molecule that is topically dosed in an eye drop and has the unique ability to penetrate cell membranes and reach both the front and the back of the eye. It is intended to treat Age-related macular Degeneration (AMD), and preclinical research results indicate additional uses for OT-551, including treatment of early stage and advanced dry age-related macular degeneration (AMD) by protecting against retina photoreceptor cell death and inhibiting angiogenesis, the growth of small blood vessels leading to the wet-form of AMD. A leading cause of vision loss, AMD affects approximately 10 million Americans.
OT-551
OT-551 [drugbank:DB05650]

(4-Hydroxymaltosephenyl)Glycine
(4-Hydroxymaltosephenyl)Glycine [drugbank:DB02675]

Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients. [PubChem]
Ketoconazole
Ketoconazole [drugbank:DB01026]

Adenosine-5'-Diphosphate-2',3'-Vanadate
Adenosine-5'-Diphosphate-2',3'-Vanadate [drugbank:DB02661]

Factor IIIm
Factor IIIm [drugbank:DB02667]

(3s)-Tetrahydrofuran-3-Yl (1r,2s)-3-[4-((1r)-2-{[(S)-Amino(Hydroxy)Methyl]Oxy}-2,3-Dihydro-1h-Inden-1-Yl)-2-Benzyl-3-Oxopyrrolidin-2-Yl]-1-Benzyl-2-Hydroxypropylcarbamate
(3s)-Tetrahydrofuran-3-Yl (1r,2s)-3-[4-((1r)-2-{[(S)-Amino(Hydroxy)Methyl]Oxy}-2,3-Dihydro-1h-Inden-1-Yl)-2-Benzyl-3-Oxopyrrolidin-2-Yl]-1-Benzyl-2-Hydroxypropylcarbamate [drugbank:DB01824]

Withdrawn from the Canadian market in July 1964 due to interactions with food products containing tyrosine.
Iproniazid
Iproniazid [drugbank:DB04818]

N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine [drugbank:DB03449]

5-ETHYL-3-[(2-METHOXYETHYL)METHYLAMINO]-6-METHYL-4-(3-METHYLBENZYL)PYRIDIN-2(1H)-ONE
5-ETHYL-3-[(2-METHOXYETHYL)METHYLAMINO]-6-METHYL-4-(3-METHYLBENZYL)PYRIDIN-2(1H)-ONE [drugbank:DB07018]

6'-Methyl-Thiamin Diphosphate
6'-Methyl-Thiamin Diphosphate [drugbank:DB01682]

Erythose-4-Phosphate
Erythose-4-Phosphate [drugbank:DB03937]

Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.
Acetaminophen
Acetaminophen [drugbank:DB00316]

2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2-METHYL-4-ISOXAZOLYL]-PHENOL
2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2-METHYL-4-ISOXAZOLYL]-PHENOL [drugbank:DB08715]

Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections.

Sulfacytine is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Sulfacytine
Sulfacytine [drugbank:DB01298]

(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid [drugbank:DB07842]

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.
Anistreplase
Anistreplase [drugbank:DB00029]

({3-[1-(4-HYDROXY-2-OXO-2H-CHROMEN-3-YL)-PROPYL]-PHENYLCARBAMOYL}-METHYL)-CARBAMIC ACID TERT-BUTYL ESTER
({3-[1-(4-HYDROXY-2-OXO-2H-CHROMEN-3-YL)-PROPYL]-PHENYLCARBAMOYL}-METHYL)-CARBAMIC ACID TERT-BUTYL ESTER [drugbank:DB08664]

An essential amino acid. It is often added to animal feed. [PubChem]
D-Lysine
D-Lysine [drugbank:DB03252]

A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses. [PubChem]
Ribavirin
Ribavirin [drugbank:DB00811]

5'-O-[(L-Methionyl)-Sulphamoyl]Adenosine
5'-O-[(L-Methionyl)-Sulphamoyl]Adenosine [drugbank:DB02229]

Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumours. FDA approved on September 27, 2012.
Regorafenib
Regorafenib [drugbank:DB08896]

Preotact is a pharmaceutical form of parathyroid hormone (PTH). PTH is a single-chain polypeptide composed of 84 amino acids. Preotact contains recombinant human parathyroid hormone which is identical to the full-length native 84-amino acid polypeptide. It is produced as a fusion protein. Post-translational processing involves the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa) whose sequence is identical to that of the full-length native endogenous human PTH. It has no disulfide bonds and no glycosylation sites.

Preotact is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures. Preotact is marketed in Europe by Nycomed. Preos is a registered trade mark owned by NPS Pharmaceuticals, Inc. The name Preos and the New Drug Application is pending approval by the U.S. Food and Drug Administration (FDA).

Preotact
Preotact [drugbank:DB05829]

2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE
2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE [drugbank:DB07548]

2-Thioethenamine
2-Thioethenamine [drugbank:DB01968]

(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide
(2E)-N-hydroxy-3-[1-methyl-4-(phenylacetyl)-1H-pyrrol-2-yl]prop-2-enamide [drugbank:DB07350]

A glucocorticoid derivative used topically in the treatment of various skin disorders. It is usually employed as a cream, gel, lotion, or ointment. It has also been used topically in the treatment of inflammatory eye, ear, and nose disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732). It is also being investigated by Sivida and Alimera, under the brand name Medidur, as a sustained release intraocular implant for the treatment of diabetic macular edema.
Fluocinolone Acetonide
Fluocinolone Acetonide [drugbank:DB00591]

1,10-Phenanthroline
1,10-Phenanthroline [drugbank:DB02365]

Grass pollen extract is a novel vaccine for treatment of seasonal allergic reactions from grass, tree or ragweed pollen allergy. Its formualation combines chemically modified allergens adsorbed onto a L-tyrosine with addition of the immunostimulatory adjuvant monophosphoryl lipid A (MPL), to improve efficacy.
grass pollen extract
grass pollen extract [drugbank:DB05357]

[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone
[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-Methanone [drugbank:DB01836]

EP-2104R is an imaging pharmaceutical under development for the detection of blood clots. It is the first targeted high-resolution technique designed to visualize blood clots directly. It is being developed by EPIX Pharmaceuticals, Inc.
EP-2104R
EP-2104R [drugbank:DB05675]

6-AMINO-4-[2-(4-METHYLPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
6-AMINO-4-[2-(4-METHYLPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE [drugbank:DB08268]

(1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL
(1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL [drugbank:DB06984]

Linaclotide is an orally administered, peptide agonist of guanylate cyclase 2C for the treatment of irritable bowel syndrome. Chemically, it is a heterodetic cyclic peptide and consists of fourteen amino acids. The protein sequence is as follows: Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr. There are three disulfide bonds which are located between Cys1 and Cys6; between Cys2 and Cys10; and between Cys5 and Cys13. FDA approved on August 30, 2012.
Linaclotide
Linaclotide [drugbank:DB08890]

Fluclorolone acetonide (INN, or flucloronide, USAN, trade names Cutanit, Topicon) is a corticosteroid for topical use on the skin. [Wikipedia]
Fluclorolone acetonide
Fluclorolone acetonide [drugbank:DB08973]

(9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one
(9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one [drugbank:DB07757]

3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC
3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC [drugbank:DB07517]

Pipecuronium is a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent.
Pipecuronium
Pipecuronium [drugbank:DB01338]

Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus. Amdinocillin is not available in the United States.
Amdinocillin
Amdinocillin [drugbank:DB01163]

N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE
N-METHYL O-NITROPHENYL AMINOETHYLDIPHOSPHATE BERYLLIUM TRIFLUORIDE [drugbank:DB08276]

6-Hydroxymethyl-7,8-Dihydropterin
6-Hydroxymethyl-7,8-Dihydropterin [drugbank:DB02119]

6-Hydroxy-Flavin-Adenine Dinucleotide
6-Hydroxy-Flavin-Adenine Dinucleotide [drugbank:DB02654]

Azidocillin is a penicillin antibiotic similir to ampicillin.
Azidocillin
Azidocillin [drugbank:DB08795]

Mivacurium is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission.
Mivacurium
Mivacurium [drugbank:DB01226]

(3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
(3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE [drugbank:DB08445]

A semi-synthetic cephalosporin antibiotic. [PubChem]
Cefradine
Cefradine [drugbank:DB01333]

1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine
1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine [drugbank:DB07563]

N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE [drugbank:DB06877]

2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE [drugbank:DB08360]

3-(5-Amino-7-Hydroxy-[1,2,3]Triazolo[4,5-D]Pyrimidin-2-Yl)-N-[2-(2-(Hydroxymethyl-Phenylsulfanyl)-Benzyl]-Benzamide
3-(5-Amino-7-Hydroxy-[1,2,3]Triazolo[4,5-D]Pyrimidin-2-Yl)-N-[2-(2-(Hydroxymethyl-Phenylsulfanyl)-Benzyl]-Benzamide [drugbank:DB03231]

Caerulein is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle.
Ceruletide
Ceruletide [drugbank:DB00403]

3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine
3-(3-methylbut-2-en-1-yl)-3H-purin-6-amine [drugbank:DB08074]

4-Deoxy-4-((5-Hydroxymethyl-2,3,4-Trihydroxycyclohex-5,6-Enyl)Amino)Fructose
4-Deoxy-4-((5-Hydroxymethyl-2,3,4-Trihydroxycyclohex-5,6-Enyl)Amino)Fructose [drugbank:DB03269]

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids
Etanercept
Etanercept [drugbank:DB00005]

D-Alanine
D-Alanine [drugbank:DB01786]

INCB13739 is developed as a new treatment for type 2 diabetes. It is an orally available small molecule inhibitor of 11beta-HSD1 (11-beta hydroxysteroid dehydrogenase type 1). 11beta-HSD1 is an enzyme that appears to be critical to the development of type 2 diabetes.
INCB13739 [drugbank:DB05064]

An arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. [PubChem]
4-Aminophenylarsonic Acid
4-Aminophenylarsonic Acid [drugbank:DB03006]

(1R)-1-PHENYLETHYL 4-(ACETYLAMINO)BENZYLPHOSPHONATE
(1R)-1-PHENYLETHYL 4-(ACETYLAMINO)BENZYLPHOSPHONATE [drugbank:DB08545]

Guanosine-5'-Diphosphate-Rhamnose
Guanosine-5'-Diphosphate-Rhamnose [drugbank:DB02547]

7-Methyl-Gpppa
7-Methyl-Gpppa [drugbank:DB01649]

5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE
5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE [drugbank:DB08173]

trans NV-04 is a cardiovascular drug which shows a significant reduction in blood pressure and arterial stiffness.
trans NV-04
trans NV-04 [drugbank:DB05843]

Pertuzumab is a recombinant humanized monoclonal antibody that targets the extracellular dimerization domain (Subdomain II) of the human epidermal growth factor receptor 2 protein (HER2). It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. FDA approved June 8, 2012.
Pertuzumab
Pertuzumab [drugbank:DB06366]

A component of phosphatidylcholines (lecithins), in which the two hydroxy groups of glycerol are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes and other macromolecules. [PubChem]
Glycerylphosphorylcholine
Glycerylphosphorylcholine [drugbank:DB04660]

Biphenylalanine
Biphenylalanine [drugbank:DB04639]

(South)-Methanocarba-Thymidine
(South)-Methanocarba-Thymidine [drugbank:DB02921]

N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE
N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE [drugbank:DB07224]

Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II). Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure. Brinzolamide is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Brinzolamide
Brinzolamide [drugbank:DB01194]

4,4'-Biphenyldiboronic Acid
4,4'-Biphenyldiboronic Acid [drugbank:DB02627]

(2R)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL
(2R)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL [drugbank:DB07750]

Axitinib is an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3. Axitinib is marketed under the name InlytaÂ®, and if one previous systemic therapy for kidney cell cancer has failed, axitinib is indicated.
Axitinib
Axitinib [drugbank:DB06626]

2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[4-METHYL-2H-TETRAZOL-2-YL]-PHENOL
2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[4-METHYL-2H-TETRAZOL-2-YL]-PHENOL [drugbank:DB08714]

4-Imino-5-Methidyl-2-Trifluoromethylpyrimidine
4-Imino-5-Methidyl-2-Trifluoromethylpyrimidine [drugbank:DB02885]

Dioxyselenocysteine
Dioxyselenocysteine [drugbank:DB02442]

Eritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.
Eritoran
Eritoran [drugbank:DB04933]

2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium
2,3-Dicarboxy-4-(2-Chloro-Phenyl)-1-Ethyl-5-Isopropoxycarbonyl-6-Methyl-Pyridinium [drugbank:DB04055]

Sulfoxone is a water-soluble sulfone used as an antileprosy drug. It has been used with limited success in the treatment of dermatitis herpetiformis.
Sulfoxone
Sulfoxone [drugbank:DB01145]

N-(1,4-DIHYDRO-5H-TETRAZOL-5-YLIDENE)-9-OXO-9H-XANTHENE-2-SULFONAMIDE
N-(1,4-DIHYDRO-5H-TETRAZOL-5-YLIDENE)-9-OXO-9H-XANTHENE-2-SULFONAMIDE [drugbank:DB04698]

4-amino-N-[4-(benzyloxy)phenyl]butanamide
4-amino-N-[4-(benzyloxy)phenyl]butanamide [drugbank:DB07104]

2-[4-(Hydroxy-Methoxy-Methyl)-Benzyl]-7-(4-Hydroxymethyl-Benzyl)-1,1-Dioxo-3,6-Bis-Phenoxymethyl-1lambda6-[1,2,7]Thiadiazepane-4,5-Diol
2-[4-(Hydroxy-Methoxy-Methyl)-Benzyl]-7-(4-Hydroxymethyl-Benzyl)-1,1-Dioxo-3,6-Bis-Phenoxymethyl-1lambda6-[1,2,7]Thiadiazepane-4,5-Diol [drugbank:DB04042]

ANA380 is a small-molecule orally available inhibitor of the HBV polymerase. The HBV polymerase is the enzyme that catalyzes the production of new RNA from the existing strand of RNA. ANA380 is believed to inhibit viral proliferation by interrupting the replicating machinery of the virus.
ANA380
ANA380 [drugbank:DB05020]

CRA_23653 [drugbank:DB04246]

T487 is a small molecule chemokine receptor antagonist to correct or modify immune system responses. It binds selectively and potently to CXCR3. The formulation is administered orally and has anti-inflammatory effects in conditions such as rheumatoid arthritis, inflammatory bowel disease and psoriasis.
T487 [drugbank:DB05474]

Thiocoumarin
Thiocoumarin [drugbank:DB02462]

Dimethylglycine
Dimethylglycine [drugbank:DB02083]

Cystein-S-Yl Cacodylate
Cystein-S-Yl Cacodylate [drugbank:DB03676]

ARC1779 is a therapeutic aptamer antagonist of the A1 domain of von Willebrand Factor (vWF), the ligand for receptor glycoprotein 1b on platelets. ARC1779 is being developed as a novel antithrombotic agent for use in patients with acute coronary syndromes. ARC1779 is a therapeutic oligonucleotide ("aptamer") which blocks the binding of the A1 domain of vWF to the platelet GPIb receptor, and thereby modulates platelet adhesion, activation, and aggregation under the high shear conditions of coronary arterial stenosis and plaque rupture.
ARC1779
ARC1779 [drugbank:DB05202]

(E)-2-Fluoro-P-Hydroxycinnamate
(E)-2-Fluoro-P-Hydroxycinnamate [drugbank:DB02384]

Cu-Bicyclam
Cu-Bicyclam [drugbank:DB02250]

An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension. [PubChem]
Metaraminol
Metaraminol [drugbank:DB00610]

Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.
Colesevelam
Colesevelam [drugbank:DB00930]

2-Amino-Vinyl-Phosphate
2-Amino-Vinyl-Phosphate [drugbank:DB02907]

4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE
4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE [drugbank:DB08072]

Clonitazene
Clonitazene [drugbank:DB01523]

Alpha-Methyl-N-Acetyl-D-Glucosamine
Alpha-Methyl-N-Acetyl-D-Glucosamine [drugbank:DB04426]

Orotic Acid
Orotic Acid [drugbank:DB02262]

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Bendroflumethiazide
Bendroflumethiazide [drugbank:DB00436]

L-Naphthyl-1-Acetamido Boronic Acid Alanine
L-Naphthyl-1-Acetamido Boronic Acid Alanine [drugbank:DB03290]

1-[2-HYDROXY-3-(4-CYCLOHEXYL-PHENOXY)-PROPYL]-4-(2-PYRIDYL)-PIPERAZINE
1-[2-HYDROXY-3-(4-CYCLOHEXYL-PHENOXY)-PROPYL]-4-(2-PYRIDYL)-PIPERAZINE [drugbank:DB08543]

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
Estriol
Estriol [drugbank:DB04573]

Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position. [PubChem]
Cytidine-5'-Monophosphate
Cytidine-5'-Monophosphate [drugbank:DB03403]

Etheno-Nadp
Etheno-Nadp [drugbank:DB03732]

GRN163L is a novel anti-cancer drug. It has been characterized preclinically and shown to inhibit telomerase in human tumor cells of many cancer types (including lung, breast, prostate, liver, and early stage of human breast cancer), in both cell culture systems and animal models. Study of this drug shows the its potential utility in the treatment of patients with hematologic and solid tumor malignancies.
Grn163l
Grn163l [drugbank:DB05036]

Bortezomib (originally PS-341 and marketed as Velcade by Millennium Pharmaceuticals) is the first therapeutic proteasome inhibitor to be tested in humans. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.
Bortezomib
Bortezomib [drugbank:DB00188]

Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption markers in patients with a variety of metastatic tumors and is being investigated in multiple clinical trials for the prevention and treatment of bone metastases. Chemically, it consists of 2 heavy and 2 light chains. Each light chain consists of 215 amino acids. Each heavy chain consists of 448 amino acids with 4 intramolecular disulfides. FDA approved on June 1, 2010.
Denosumab
Denosumab [drugbank:DB06643]

5,10,15,20-Tetrakis(4-Sulpfonatophenyl)-21h,23h-Porphine [drugbank:DB01999]

Methyl-[4-(4-Piperidine-1-Ylmethyl-Phenyl)-Cyclohexyl]-Carbaminic Acid-(4-Chlorophenyl)-Ester
Methyl-[4-(4-Piperidine-1-Ylmethyl-Phenyl)-Cyclohexyl]-Carbaminic Acid-(4-Chlorophenyl)-Ester [drugbank:DB03748]

XL184 is an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL184 strongly binds to and inhibits several tyrosine receptor kinases. Specifically, XL184 appears to have a strong affinity for the hepatocyte growth factor receptor (Met) and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in inhibition of tumor growth and angiogenesis, and tumor regression. This agent has also been shown to inhibit mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (Flt3) and tyrosine-protein kinase receptor (Tie-2).
XL184
XL184 [drugbank:DB05153]

3-{[(2,2,5,5-TETRAMETHYL-1-OXO-4-PHENYL-2,5-DIHYDRO-1H-PYRROLIUM-3-YL)METHYL]DISULFANYL}-D-ALANINE
3-{[(2,2,5,5-TETRAMETHYL-1-OXO-4-PHENYL-2,5-DIHYDRO-1H-PYRROLIUM-3-YL)METHYL]DISULFANYL}-D-ALANINE [drugbank:DB08456]

A biguanide hypoglycemic agent with actions and uses similar to those of metformin. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Phenformin
Phenformin [drugbank:DB00914]

4-{[(2,6-dichlorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamide
4-{[(2,6-dichlorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamide [drugbank:DB08142]

A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.
Iron
Iron [drugbank:DB01592]

Doxorubicin Transdrug(R) is an investigational drug to treat hepatocellular carcinoma (HCC), primary liver cancer.
doxorubicin TransDrug
doxorubicin TransDrug [drugbank:DB05331]

A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Lamivudine
Lamivudine [drugbank:DB00709]

1-Monooleoyl-Rac-Glycerol
1-Monooleoyl-Rac-Glycerol [drugbank:DB03831]

2-Nitro-P-Cresol
2-Nitro-P-Cresol [drugbank:DB04110]

4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE
4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE [drugbank:DB08241]

SR-123781A is a synthetic hexadecasaccharide Factor IIa and Xa antagonist. It is under investigation by Sanofi-Aventis and Organon for the treatment of thrombosis and acute coronary syndromes (ACS).
SR-123781A [drugbank:DB05361]

An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. [PubChem]
Clemastine
Clemastine [drugbank:DB00283]

6-Hydroxy-6-Methyl-Heptan-3-One
6-Hydroxy-6-Methyl-Heptan-3-One [drugbank:DB03711]

N-(ethoxycarbonyl)-L-leucine
N-(ethoxycarbonyl)-L-leucine [drugbank:DB06839]

CF 101 (known generically as IB-MECA) is an anti-inflammatory drug for rheumatoid arthritis patients. Its novel mechanism of action relies on antagonism of adenoside A3 receptors. CF101 is supplied as an oral drug and has an excellent safety profile. It is also being considered for the treatment of other autoimmune-inflammatory disorders, such as Crohn's disease, psorasis and dry eye syndrome.
CF-101
CF-101 [drugbank:DB05511]

4-Amino-N-{4-[2-(2,6-Dimethyl-Phenoxy)-Acetylamino]-3-Hydroxy-1-Isobutyl-5-Phenyl-Pentyl}-Benzamide
4-Amino-N-{4-[2-(2,6-Dimethyl-Phenoxy)-Acetylamino]-3-Hydroxy-1-Isobutyl-5-Phenyl-Pentyl}-Benzamide [drugbank:DB04373]

4-Hydroxybenzoyl Coenzyme A
4-Hydroxybenzoyl Coenzyme A [drugbank:DB01652]

An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. [PubChem]
Foscarnet
Foscarnet [drugbank:DB00529]

[Methylthio]Acetate
[Methylthio]Acetate [drugbank:DB03517]

A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. [PubChem]
Enoxacin
Enoxacin [drugbank:DB00467]

5-(5-(2,6-DICHLORO-4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)PENTYL)-3-(HYDROXYETHYL OXYMETHYLENEOXYMETHYL) ISOXAZOLE
5-(5-(2,6-DICHLORO-4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)PENTYL)-3-(HYDROXYETHYL OXYMETHYLENEOXYMETHYL) ISOXAZOLE [drugbank:DB08721]

CHF 4227 is a new selective estrogen receptor modulator (SERM). The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone loss in animal models of osteoporosis. Additionally, the compound has shown no uterotrophic activity suggesting a potential therapeutic advantage over drugs normally used in postmenopausal therapy.
CHF 4227
CHF 4227 [drugbank:DB05882]

Pralatrexate is an antimetabolite for the treatment of relapsed or refractory peripheral T-cell lymphoma. It is more efficiently retained in cancer cells than methotrexate. FDA approved on September 24, 2009.
Pralatrexate
Pralatrexate [drugbank:DB06813]

2-Iminobiotin
2-Iminobiotin [drugbank:DB03353]

2-[(2e,6e,10e,14e,18e,22e,26e)-3,7,11,15,19,23,27,31-Octamethyldotriaconta-2,6,10,14,18,22,26,30-Octaenyl]Phenol [drugbank:DB03232]

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cancer. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit is nearly identical to that of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The alpha subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The beta subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.
Thyrotropin Alfa
Thyrotropin Alfa [drugbank:DB00024]

5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE [drugbank:DB08350]

Trypanothione
Trypanothione [drugbank:DB03470]

Oregovomab is a murine monoclonal antibody that attaches to the tumor-associated antigen CA125.
Oregovomab
Oregovomab [drugbank:DB04964]

PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE
PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE [drugbank:DB08377]

Thioproline
Thioproline [drugbank:DB02846]

Dazoxiben
Dazoxiben [drugbank:DB03052]

Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. [PubChem]
Isoniazid
Isoniazid [drugbank:DB00951]

PAS219
PAS219 [drugbank:DB03114]

Succinyl-Coenzyme A
Succinyl-Coenzyme A [drugbank:DB03699]

A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of adenylate cyclase. [PubChem]
Phosphoaminophosphonic Acid Guanylate Ester
Phosphoaminophosphonic Acid Guanylate Ester [drugbank:DB02082]

S-(Dimethylarsenic)Cysteine
S-(Dimethylarsenic)Cysteine [drugbank:DB03963]

2-[(1R)-1-carboxy-2-naphthalen-1-ylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
2-[(1R)-1-carboxy-2-naphthalen-1-ylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid [drugbank:DB06922]

Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
Cyclohexyl-{4-[5-(3,4-Dichlorophenyl)-2-Piperidin-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine [drugbank:DB02388]

4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine [drugbank:DB08178]

A glucocorticoid employed, usually as eye drops, in the treatment of allergic and inflammatory conditions of the eye. It has also been used topically in the treatment of various skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p732)
Fluorometholone
Fluorometholone [drugbank:DB00324]

3-Hydroxyisoxazole-4-Carboxylic Acid
3-Hydroxyisoxazole-4-Carboxylic Acid [drugbank:DB02111]

5'-ACETYL-4-{[(2,4-DIMETHYLPHENYL)SULFONYL]AMINO}-2,2'-BITHIOPHENE-5-CARBOXYLIC ACID
5'-ACETYL-4-{[(2,4-DIMETHYLPHENYL)SULFONYL]AMINO}-2,2'-BITHIOPHENE-5-CARBOXYLIC ACID [drugbank:DB08556]

N-Methyldehydrobutyrine
N-Methyldehydrobutyrine [drugbank:DB04225]

6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID
6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID [drugbank:DB08397]

1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea
1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea [drugbank:DB07817]

Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. [Wikipedia]
N,N-dimethylarginine
N,N-dimethylarginine [drugbank:DB01686]

4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID [drugbank:DB08060]

Vitamin B6 Complexed with 2-Amino-Pentanoic Acid
Vitamin B6 Complexed with 2-Amino-Pentanoic Acid [drugbank:DB03662]

IR208 is a synthetic T-Cell receptor peptide vaccine developed by Immune Response Corporation. It contains three peptides (BV5S2, BV6S5 and BV13S1) expressed by T-Cells in over 90% of MS patients. IR208 is currently undergoing Phase II studies in a 200-patient trial.
IR208
IR208 [drugbank:DB05106]

4-[(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)amino]-4-oxobutanoic acid
4-[(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)amino]-4-oxobutanoic acid [drugbank:DB08581]

(2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid
(2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid [drugbank:DB07448]

[3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium
[3-(Dodecanoylamino)Propyl](Hydroxy)Dimethylammonium [drugbank:DB01736]

An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections. [PubChem]
Lincomycin
Lincomycin [drugbank:DB01627]

4-Methylumbelliferyl Chitobiose
4-Methylumbelliferyl Chitobiose [drugbank:DB02759]

{4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid
{4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid [drugbank:DB01830]

An antibiotic produced by Streptomyces fradiae. [PubChem]
Fosfomycin
Fosfomycin [drugbank:DB00828]

Sulfoquinovose-Uridine-C1,5'-Diphosphate
Sulfoquinovose-Uridine-C1,5'-Diphosphate [drugbank:DB02554]

5-methyl-6-phenylquinazoline-2,4-diamine
5-methyl-6-phenylquinazoline-2,4-diamine [drugbank:DB08317]

2,5-Dimethoxyamphetamine
2,5-Dimethoxyamphetamine [drugbank:DB01465]

ABT-560 is a neuronal nicotinic receptor (NNR) modulator, which has shown promise in preclinical models relevant for the treatment of cognitive deficits.
ABT-560
ABT-560 [drugbank:DB06093]

Arsenic trioxide is a chemotheraputic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. Due to the toxic nature of arsenic, this drug carries significant health risks. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.
Arsenic trioxide
Arsenic trioxide [drugbank:DB01169]

Benzhydroxamic Acid
Benzhydroxamic Acid [drugbank:DB01924]

S-Mercaptocysteine
S-Mercaptocysteine [drugbank:DB02761]

5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE [drugbank:DB07244]

Malachite Green
Malachite Green [drugbank:DB03895]

2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine [drugbank:DB01905]

2-(Pyrido[1,2-E]Purin-4-Yl)Amino-Ethanol
2-(Pyrido[1,2-E]Purin-4-Yl)Amino-Ethanol [drugbank:DB01994]

2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide
2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide [drugbank:DB08046]

[4,6-O-(1-CARBOXYETHYLIDENE)-BETA-D-MANNOSE]
[4,6-O-(1-CARBOXYETHYLIDENE)-BETA-D-MANNOSE] [drugbank:DB04597]

HYDROXYFASUDIL
HYDROXYFASUDIL [drugbank:DB04707]

PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATE
PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATE [drugbank:DB07893]

Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor. It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
Mepenzolate
Mepenzolate [drugbank:DB04843]

Cyclohexane
Cyclohexane [drugbank:DB03561]

4-Oxoretinol
4-Oxoretinol [drugbank:DB02699]

3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE [drugbank:DB08577]

Drotebanol
Drotebanol [drugbank:DB01547]

2-(1H-INDOL-3-YL)ACETAMIDE
2-(1H-INDOL-3-YL)ACETAMIDE [drugbank:DB08652]

N-[2-Hydroxy-2-(8-Isopropyl-6,9-Dioxo-2-Oxa-7,10-Diaza-Bicyclo[11.2.2]Heptadeca-1(16),13(17),14-Trien-11-Yl)-Ethyl]-N-(3-Methyl-Butyl)-Benzenesulfonamide,Inhibitor 3
N-[2-Hydroxy-2-(8-Isopropyl-6,9-Dioxo-2-Oxa-7,10-Diaza-Bicyclo[11.2.2]Heptadeca-1(16),13(17),14-Trien-11-Yl)-Ethyl]-N-(3-Methyl-Butyl)-Benzenesulfonamide,Inhibitor 3 [drugbank:DB03768]

Acrylic Acid
Acrylic Acid [drugbank:DB02579]

A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the central nervous system. [PubChem]
D-Glutamic Acid
D-Glutamic Acid [drugbank:DB02517]

Ribose
Ribose [drugbank:DB01936]

2-((4'-HYDROXYPHENYL)-AZO)BENZOIC ACID
2-((4'-HYDROXYPHENYL)-AZO)BENZOIC ACID [drugbank:DB07880]

Desomorphine
Desomorphine [drugbank:DB01531]

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. [PubChem]
Morphine
Morphine [drugbank:DB00295]

PHENANTHRENE
PHENANTHRENE [drugbank:DB08381]

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Spironolactone
Spironolactone [drugbank:DB00421]

Ty800 is a vaccine designed to offer rapid, oral, single-dose protection against Salmonella typhi, the cause of typhoid fever. The Ty800 vaccine was developed using genetic techniques to delete specific genes known to be essential to the virulence of S. typhi. It is being developed by AVANT Immunotherapeutics, Inc.
Ty800
Ty800 [drugbank:DB04989]

6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one
6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one [drugbank:DB07628]

(1s,2s)-1-Amino-1-(1,3-Thiazol-2-Yl)Propan-2-Ol
(1s,2s)-1-Amino-1-(1,3-Thiazol-2-Yl)Propan-2-Ol [drugbank:DB03724]

Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.
Crizotinib
Crizotinib [drugbank:DB08865]

An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
Levallorphan
Levallorphan [drugbank:DB00504]

Bis(5-Amidino-Benzimidazolyl)Methane Zinc
Bis(5-Amidino-Benzimidazolyl)Methane Zinc [drugbank:DB04008]

3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile
3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile [drugbank:DB08460]

A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem]
Aminolevulinic acid
Aminolevulinic acid [drugbank:DB00855]

An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. [PubChem]
Sufentanil
Sufentanil [drugbank:DB00708]

8-Amino-1,3-Dimethyl-3,7-Dihydropurine-2,6-Dione
8-Amino-1,3-Dimethyl-3,7-Dihydropurine-2,6-Dione [drugbank:DB01778]

Satraplatin is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. As an investigation drug, it has not yet received U.S. Food and Drug Administration (FDA) approval and is not available in retail pharmacies.
Satraplatin
Satraplatin [drugbank:DB04996]

Phenylethane Boronic Acid
Phenylethane Boronic Acid [drugbank:DB01963]

Ivermectin is a broad-spectrum anti-parasite medication. It was first marketed under the name StromectolÂ® and used against worms (except tapeworms), but, in 2012, it was approved for the topical treatment of head lice infestations in patients 6 months of age and older, and marketed under the name Skliceâ¢ as well. Ivermectin is mainly used in humans in the treatment of onchocerciasis, but is also effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis).
Ivermectin
Ivermectin [drugbank:DB00602]

N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID
N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID [drugbank:DB08507]

2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE
2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE [drugbank:DB08326]

A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. [PubChem]
Sulfinpyrazone
Sulfinpyrazone [drugbank:DB01138]

8-Oxo-2'-Deoxy-Guanosine-5'-Monophosphate
8-Oxo-2'-Deoxy-Guanosine-5'-Monophosphate [drugbank:DB02023]

Roxithromycin is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. It can treat respiratory tract, urinary and soft tissue infections. It is not available in the United States, but is available in Australia.
Roxithromycin
Roxithromycin [drugbank:DB00778]

GM6001
GM6001 [drugbank:DB02255]

A potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. [PubChem]
Dihydrotestosterone
Dihydrotestosterone [drugbank:DB02901]

Insulin aspart is a recombinant, biosynthetic, fast-acting insulin analogue. It has a single amino acid substitution at position B28 where proline is replaced with aspartic acid. This substitution decreases its propensity to form hexamers and gives it a higher rate of absorption following subcutaneous administration compared to native insulin. Insulin aspart is produced in a genetically modified strain of _Saccharomyces cerevisiae_ and harvested from a bioreactor.
Insulin Aspart
Insulin Aspart [drugbank:DB01306]

Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
Corticotropin
Corticotropin [drugbank:DB01285]

A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid. [PubChem]
Pentagastrin
Pentagastrin [drugbank:DB00183]

An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins. [PubChem]
L-Threonine
L-Threonine [drugbank:DB00156]

Dcka, 5,7-Dichlorokynurenic Acid
Dcka, 5,7-Dichlorokynurenic Acid [drugbank:DB01931]

One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. [PubChem]
Cefotiam
Cefotiam [drugbank:DB00229]

3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE [drugbank:DB07715]

N-Aminoethylmorpholine
N-Aminoethylmorpholine [drugbank:DB03096]

N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE
N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE [drugbank:DB07800]

2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE [drugbank:DB08465]

Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Trimethobenzamide
Trimethobenzamide [drugbank:DB00662]

Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.
Histamine Phosphate
Histamine Phosphate [drugbank:DB00667]

(2R)-2-PHENYL-N-PYRIDIN-4-YLBUTANAMIDE
(2R)-2-PHENYL-N-PYRIDIN-4-YLBUTANAMIDE [drugbank:DB06890]

(1S,2R)-2-[(2,5-difluorophenyl)carbamoyl]cyclopropanecarboxylic acid
(1S,2R)-2-[(2,5-difluorophenyl)carbamoyl]cyclopropanecarboxylic acid [drugbank:DB07808]

XL999 has the potential to provide benefit to patients with lung cancer and acute myelogenous leukemia. XL999 is a new chemical entity that inhibits a spectrum of receptor tyrosine kinases (RTKs) with growth promoting and angiogenic properties, including FGFR 1/3, PDGFRÎ±/Î², VEGFR2/KDR, KIT, and FLT3. XL999 also inhibits FLT4 and SRC. XL999 has the potential to prevent tumor growth â both directly by a novel effect on tumor cell proliferation and indirectly through inhibition of the host angiogenic response. XL999 induces a cell-cycle block by a mechanism distinct from those previously identified and exhibits broad antitumor activity in xenograft models.
XL999
XL999 [drugbank:DB05014]

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. [PubChem]
Meticillin
Meticillin [drugbank:DB01603]

Denufosol (INN) is an inhaled drug for the treatment of cystic fibrosis, being developed by Inspire Pharmaceuticals and sponsored by the Cystic Fibrosis Foundation. It was tested in two Phase III clinical trials, TIGER-1 and TIGER-2. Initially, in the first Phase III trial, TIGER-1, the compound showed significant results as compared with placebo. In the second Phase III trial, TIGER-2, the compound did not meet the primary endpoint, a significant change in baseline FEV1 (forced expiratory volume in one second) at the week 48 endpoint as compared to placebo. As of 2011, no additional clinical studies are being conducted with the compound. The drug was also investigated for the treatment of retinal detachment and other retinal diseases, but trials were terminated in 2006. [Wikipedia]
Denufosol
Denufosol [drugbank:DB04983]

Alpha-Methylene Adenosine Monophosphate
Alpha-Methylene Adenosine Monophosphate [drugbank:DB02798]

D-Methionine
D-Methionine [drugbank:DB02893]

Vinylglycine is an irreversible inhibitor of aspartate aminotransferase.
Vinylglycine
Vinylglycine [drugbank:DB03214]

L-2-Amino-4-Methoxy-Cis-but-3-Enoic Acid
L-2-Amino-4-Methoxy-Cis-but-3-Enoic Acid [drugbank:DB03611]

Etoxeridine
Etoxeridine [drugbank:DB01505]

(6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE [drugbank:DB07604]

2-O-Methyl Fucose
2-O-Methyl Fucose [drugbank:DB03863]

N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide [drugbank:DB07833]

N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE
N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE [drugbank:DB08324]

(4r,5s,6s,7r)-1,3-Dibenzyl-4,7-Bis(Phenoxymethyl)-5,6-Dihydroxy-1,3 Diazepan-2-One
(4r,5s,6s,7r)-1,3-Dibenzyl-4,7-Bis(Phenoxymethyl)-5,6-Dihydroxy-1,3 Diazepan-2-One [drugbank:DB01732]

3-BENZYLOXYCARBONYLAMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID
3-BENZYLOXYCARBONYLAMINO-2-HYDROXY-4-PHENYL-BUTYRIC ACID [drugbank:DB08041]

Rylomine (intranasal morphine), is currently in Phase 3 development in the United States, for moderate-to-severe pain in supervised healthcare settings. It employs the patented and proprietary, Chysis(R) drug-delivery platform to adhere and regularize the kinet
intranasal morphine
intranasal morphine [drugbank:DB05354]

Triazolopyridine
Triazolopyridine [drugbank:DB04797]

Recombinant human relaxin is a hormone produced during pregnancy that facilitates the birth process by causing a softening and lengthening of the cervix and the pubic symphysis (the place where the pubic bones come together).It is a heterodimer protein secreted by the corpus luteum and placenta during pregnancy.
recombinant human relaxin
recombinant human relaxin [drugbank:DB05794]

4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol
4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol [drugbank:DB04020]

(1-HYDROXY-1-PHOSPHONO-2-[1,1';4',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID
(1-HYDROXY-1-PHOSPHONO-2-[1,1';4',1'']TERPHENYL-3-YL-ETHYL)-PHOSPHONIC ACID [drugbank:DB07409]

IDD594
IDD594 [drugbank:DB08084]

N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine
N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine [drugbank:DB02062]

N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE
N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE [drugbank:DB08221]

Chromophore (Met-Tyr-Gly)
Chromophore (Met-Tyr-Gly) [drugbank:DB03391]

tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate
tripotassium (1R)-4-biphenyl-4-yl-1-phosphonatobutane-1-sulfonate [drugbank:DB07424]

N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide
N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide [drugbank:DB08029]

One of the selective estrogen receptor modulators (SERM) with tissue-specific activities for the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium. [PubChem]
Tamoxifen
Tamoxifen [drugbank:DB00675]

6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE
6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE [drugbank:DB07202]

Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.
Efalizumab
Efalizumab [drugbank:DB00095]

AL7099A
AL7099A [drugbank:DB03221]

Acetone Cyanohydrin
Acetone Cyanohydrin [drugbank:DB02203]

Phosphomethylphosphonic Acid Guanosyl Ester
Phosphomethylphosphonic Acid Guanosyl Ester [drugbank:DB03486]

N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide
N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide [drugbank:DB08752]

N-(1-PHENYL-PROPYL)-FORMAMIDE
N-(1-PHENYL-PROPYL)-FORMAMIDE [drugbank:DB07436]

2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL [drugbank:DB08393]

3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE
3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE [drugbank:DB08614]

TESTOSTERONE HEMISUCCINATE
TESTOSTERONE HEMISUCCINATE [drugbank:DB08619]

Pteroic Acid
Pteroic Acid [drugbank:DB04196]

VP025, a novel drug formulation based on phospholipid microparticles incorporating phosphatidylglycerol, can inhibit neuroinflammation. VP025 may inhibit immune system activation and protect motoneurons from injury. It also shows the ability to reduce inflammation across the blood-brain barrier and improve correlates of memory and learning function. It is being developed to target the chronic inflammation within the central nervous system that is associated with a number of neurological diseases, including Alzheimerâs disease, Parkinsonâs disease, and amyotrophic lateral sclerosis (Lou Gehrigâs disease). It is considered to be a systemic anti-inflammatory and neuroprotective agent.
VP025
VP025 [drugbank:DB05133]

3-Amino-N-{4-[2-(2,6-Dimethyl-Phenoxy)-Acetylamino]-3-Hydroxy-1-Isobutyl-5-Phenyl-Pentyl}-Benzamide
3-Amino-N-{4-[2-(2,6-Dimethyl-Phenoxy)-Acetylamino]-3-Hydroxy-1-Isobutyl-5-Phenyl-Pentyl}-Benzamide [drugbank:DB04378]

(METHYLPYRIDAZINE PIPERIDINE PROPYLOXYPHENYL)ETHYLACETATE
(METHYLPYRIDAZINE PIPERIDINE PROPYLOXYPHENYL)ETHYLACETATE [drugbank:DB08013]

5-methylbenzimidazole
5-methylbenzimidazole [drugbank:DB03177]

5'-O-(N-(L-Seryl)-Sulfamoyl)Adenosine
5'-O-(N-(L-Seryl)-Sulfamoyl)Adenosine [drugbank:DB03869]

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste.

Piperazine was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful.

Piperazine was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.

Piperazine
Piperazine [drugbank:DB00592]

Alpha-ketoisovalerate
Alpha-ketoisovalerate [drugbank:DB04074]

1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one
1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one [drugbank:DB08738]

The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Alpha-Phosphoribosylpyrophosphoric Acid
Alpha-Phosphoribosylpyrophosphoric Acid [drugbank:DB01632]

Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor(NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of adult HIV-1 infection documented to be resistant to therapy with other NNRTIs and antiretroviral agents. On March 26, 2012, approval was extended for use in treatment-experienced pediatric patients 6 to 18 years of age, weighing at least 16 kg. Etravarine must always be used in combination with other antiretroviral drugs.

Etravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency virus type 1 (HIV-1), and consequently blocks DNA-dependent and RNA-dependent polymerase activity. Etravirine does not inhibit human DNA polymerase alpha, beta or gamma.

Common side effects of use include mild to moderate rash within the first 6 weeks of therapy, nausea, diarrhea and peripheral neuropathy. Patients are advised to immediately contact their healthcare provider if a rash develops.

In 2009, postmarketing case reports of Stevens-Johnson Syndrome, toxic epidermal necrolysis, erythema multiforme, and other hypersensitivity reactions lead to a revision of etravirine's "Warnings and Precautions," as well as notification of health care providers.

In 2013, reports of Autoimmune disorders (such as Gravesâ disease, polymyositis, and Guillain-BarrÃ© syndrome) in the setting of immune reconstitution, as well as more in depth information about the development of rashes in patients taking etravirine, lead to a modification of etravirine's monograph.

Etravirine
Etravirine [drugbank:DB06414]

3-Methyl-thiofentanyl is an opioid analgesic that is an analogue of fentanyl.
3-Methylthiofentanyl
3-Methylthiofentanyl [drugbank:DB01439]

3-[[N-[4-Methyl-Piperazinyl]Carbonyl]-Phenylalaninyl-Amino]-5-Phenyl-Pentane-1-Sulfonic Acid Benzyloxy-Amide
3-[[N-[4-Methyl-Piperazinyl]Carbonyl]-Phenylalaninyl-Amino]-5-Phenyl-Pentane-1-Sulfonic Acid Benzyloxy-Amide [drugbank:DB04427]

NM100060 is NexMed's proprietary nail lacquer treatment for onychomycosis (nail fungal infection).
NM100060 [drugbank:DB04927]

TD-5108 is a highly selective serotonin receptor agonist effective in patients with chronic constipation. It is being developed by Theravance. TD-5108 was discovered by Theravance through the application of its multivalent drug design in a research program dedicated to finding new treatments for GI motility disorders.
TD-5108 [drugbank:DB05655]

Alrestatin
Alrestatin [drugbank:DB02020]

1,2-Dihydroxybenzene
1,2-Dihydroxybenzene [drugbank:DB02232]

O-DECYL HYDROGEN THIOCARBONATE
O-DECYL HYDROGEN THIOCARBONATE [drugbank:DB08684]

Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing activation of the GPIIb/IIIa receptor complex. As a result, inhibition of ADP-mediated platelet activation and aggregation occurs. Prasugrel was developed by Daiichi Sankyo Co. and is currently marketed in the United States and Canada in cooperation with Eli Lilly and Company for acute coronary syndromes planned for percutaneous coronary intervention (PCI). FDA approved in 2009.
Prasugrel
Prasugrel [drugbank:DB06209]

7n-Methyl-8-Hydroguanosine-5'-Monophosphate
7n-Methyl-8-Hydroguanosine-5'-Monophosphate [drugbank:DB04259]

Isothipendyl is an antihistamine and anticholinergic used as an antipruritic.
Isothipendyl
Isothipendyl [drugbank:DB08802]

PS433540 is the first and only dual-acting angiotensin and endothelin receptor antagonist (DARA) in development. The study showed all doses of PS433540 compared with placebo produced a statistically significant inhibition of the expected angiotensin (AII) induced increase in blood pressure.
PS433540 [drugbank:DB05206]

6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine [drugbank:DB08597]

Formycin-5'-Monophosphate
Formycin-5'-Monophosphate [drugbank:DB03464]

Benzylmorphine
Benzylmorphine [drugbank:DB01573]

METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE [drugbank:DB08330]

2H-1-BENZOPYRAN-2-ONE
2H-1-BENZOPYRAN-2-ONE [drugbank:DB04665]

N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE [drugbank:DB08489]

Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.
Ospemifene
Ospemifene [drugbank:DB04938]

A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism. [PubChem]
Cyanamide
Cyanamide [drugbank:DB02679]

O1-Methyl-4-Deoxy-4-Thio-Alpha-D-Glucose
O1-Methyl-4-Deoxy-4-Thio-Alpha-D-Glucose [drugbank:DB03406]

(6e)-6-[(2e,4e,6e)-3,7-Dimethylnona-2,4,6,8-Tetraenylidene]-1,5,5-Trimethylcyclohexene
(6e)-6-[(2e,4e,6e)-3,7-Dimethylnona-2,4,6,8-Tetraenylidene]-1,5,5-Trimethylcyclohexene [drugbank:DB02914]

1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID
1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID [drugbank:DB07329]

N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE
N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE [drugbank:DB04721]

17Alpha-methyl-4-hydroxynandrolone is a schedule 3 anabolic steroid.
17Alpha-methyl-4-hydroxynandrolone
17Alpha-methyl-4-hydroxynandrolone [drugbank:DB01540]

Cerulenin is an antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to b-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. It is also shown to inhibit feeding and induce dramatic weight loss in mice. It is found naturally in the Cephalosporium caerulensfungus. [Wikipedia]
Cerulenin
Cerulenin [drugbank:DB01034]

3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-chlorobenzonitrile
3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-chlorobenzonitrile [drugbank:DB08446]

Quinapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to quinaprilat (quinapril diacid) following oral administration. Quinaprilat is a competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Quinapril may be used to treat essential hypertension and congestive heart failure.
Quinapril
Quinapril [drugbank:DB00881]

Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem]
Loratadine
Loratadine [drugbank:DB00455]

EPIBATIDINE
EPIBATIDINE [drugbank:DB07720]

2,4-Diaminobutyric Acid
2,4-Diaminobutyric Acid [drugbank:DB03817]

(2S)-hydroxy(4-hydroxyphenyl)ethanoic acid
(2S)-hydroxy(4-hydroxyphenyl)ethanoic acid [drugbank:DB07896]

A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors. [PubChem]
Methylscopolamine bromide
Methylscopolamine bromide [drugbank:DB00462]

L-Alpha-Phosphatidyl-Beta-Oleoyl-Gamma-Palmitoyl-Phosphatidylethanolamine
L-Alpha-Phosphatidyl-Beta-Oleoyl-Gamma-Palmitoyl-Phosphatidylethanolamine [drugbank:DB03047]

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Propylthiouracil
Propylthiouracil [drugbank:DB00550]

beta-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs). Î²-Naphthoflavone is a putative chemopreventive agent.
beta-Naphthoflavone
beta-Naphthoflavone [drugbank:DB06732]

8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine [drugbank:DB04505]

4-[5-[2-(1-Phenyl-Ethylamino)-Pyrimidin-4-Yl]-1-Methyl-4-(3-Trifluoromethylphenyl)-1h-Imidazol-2-Yl]-Piperidine
4-[5-[2-(1-Phenyl-Ethylamino)-Pyrimidin-4-Yl]-1-Methyl-4-(3-Trifluoromethylphenyl)-1h-Imidazol-2-Yl]-Piperidine [drugbank:DB01761]

Tetrazolyl Histidine
Tetrazolyl Histidine [drugbank:DB02528]

Malonic acid
Malonic acid [drugbank:DB02175]

(4e)-4-Aminohex-4-Enoic Acid
(4e)-4-Aminohex-4-Enoic Acid [drugbank:DB01699]

Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence the name), that is located in the center of the brain (rostro-dorsal to the superior colliculus) but outside the blood-brain barrier. The secretion of melatonin increases in darkness and decreases during exposure to light, thereby regulating the circadian rhythms of several biological functions, including the sleep-wake cycle. In particular, melatonin regulates the sleep-wake cycle by chemically causing drowsiness and lowering the body temperature. Melatonin is also implicated in the regulation of mood, learning and memory, immune activity, dreaming, fertility and reproduction. Melatonin is also an effective antioxidant. Most of the actions of melatonin are mediated through the binding and activation of melatonin receptors. Individuals with autism spectrum disorders (ASD) may have lower than normal levels of melatonin. A 2008 study found that unaffected parents of individuals with ASD also have lower melatonin levels, and that the deficits were associated with low activity of the ASMT gene, which encodes the last enzyme of melatonin synthesis. Reduced melatonin production has also been proposed as a likely factor in the significantly higher cancer rates in night workers.
Melatonin
Melatonin [drugbank:DB01065]

(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER
(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER [drugbank:DB08549]

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
Maprotiline
Maprotiline [drugbank:DB00934]

NV1020, a genetically engineered herpes simplex virus, is a novel anticancer therapeutic.
NV1020
NV1020 [drugbank:DB04969]

N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE
N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE [drugbank:DB07128]

Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible.
Iron Dextran
Iron Dextran [drugbank:DB00893]

2'-O-Acetyl Adenosine-5-Diphosphoribose
2'-O-Acetyl Adenosine-5-Diphosphoribose [drugbank:DB03478]

A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
Methyltrienolone
Methyltrienolone [drugbank:DB02998]

3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate [drugbank:DB04366]

Alpha-Difluoromethylornithine
Alpha-Difluoromethylornithine [drugbank:DB03856]

(R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE
(R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE [drugbank:DB08367]

Heptane-1,2,3-Triol
Heptane-1,2,3-Triol [drugbank:DB04079]

2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID
2-{[N-(2-ACETYL-5-CHLORO-4-FLUOROPHENYL)GLYCYL]AMINO}BENZOIC ACID [drugbank:DB07085]

N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA
N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA [drugbank:DB06971]

5-Methyl-2'-Deoxypseudouridine
5-Methyl-2'-Deoxypseudouridine [drugbank:DB03763]

2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide [drugbank:DB08361]

Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.
Maraviroc
Maraviroc [drugbank:DB04835]

(2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
(2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid [drugbank:DB07516]

5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL
5-{2-[1-(1-METHYL-PROPYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-2-METHYLENE-CYCLOHEXANE-1,3-DIOL [drugbank:DB08696]

NCX 950, beta2-adrenoceptor agonists is widely used in the treatment of pulmonary diseases.
NCX 950
NCX 950 [drugbank:DB05849]

(3s)-3-Amino-1-(Cyclopropylamino)Heptane-2,2-Diol
(3s)-3-Amino-1-(Cyclopropylamino)Heptane-2,2-Diol [drugbank:DB02408]

N-METHYL-4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
N-METHYL-4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE [drugbank:DB08122]

3-Pyridin-4-Yl-2,4-Dihydro-Indeno[1,2-.C.]Pyrazole
3-Pyridin-4-Yl-2,4-Dihydro-Indeno[1,2-.C.]Pyrazole [drugbank:DB03490]

Methyl Mercury Ion
Methyl Mercury Ion [drugbank:DB03674]

Acyclovir which has chemical name as acycloguanosine, is a guanine analogue antiviral drug, marketed under trade names such as Zovirax and Zovir (GSK). One of the most commonly-used antiviral drugs, it is primarily used for the treatment of herpes simplex virus infections, as well as in the treatment of herpes zoster (shingles).
iontophoretic acyclovir
iontophoretic acyclovir [drugbank:DB05347]

VGV-1 is a potential salvage therapy for treatment of HIV infected people who have failed anti-retroviral therapy.
VGV-1
VGV-1 [drugbank:DB05328]

A direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened gangrene. [PubChem]
Pyridin-3-Ylmethanol
Pyridin-3-Ylmethanol [drugbank:DB04145]

4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID
4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID [drugbank:DB08378]

Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide
Aminodi(Ethyloxy)Ethylaminocarbonylbenzenesulfonamide [drugbank:DB02535]

Indole-3-Propanol Phosphate
Indole-3-Propanol Phosphate [drugbank:DB03171]

1-((2-HYDROXYETHOXY)METHYL)-5-(PHENYLTHIO)PYRIMIDINE-2,4(1H,3H)-DIONE
1-((2-HYDROXYETHOXY)METHYL)-5-(PHENYLTHIO)PYRIMIDINE-2,4(1H,3H)-DIONE [drugbank:DB06872]

Hexoprenaline is a stimulant of beta 2 adrenergic receptors. It is used as a bronchodilator, antiasthmatic, and tocolytic agent.
Hexoprenaline
Hexoprenaline [drugbank:DB08957]

1-(Isopropylamino)-3-(1-Naphthyloxy)-2-Propanol
1-(Isopropylamino)-3-(1-Naphthyloxy)-2-Propanol [drugbank:DB03322]

A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics. [PubChem]
Thiothixene
Thiothixene [drugbank:DB01623]

Tiludronate is a bisphosphonate characterized by a (4-chlorophenylthio) group on the carbon atom of the basic P-C-P structure common to all bisphosphonates.
Tiludronate
Tiludronate [drugbank:DB01133]

At low concentrations, this compound inhibits reduction of conventional hydrophilic electron acceptors, probably acting as a plastoquinone antagonist. At higher concentrations, it acts as an electron acceptor, intercepting electrons either before or at the site of its inhibitory activity. [PubChem]
Dibromothymoquinone
Dibromothymoquinone [drugbank:DB04646]

N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester)
N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester) [drugbank:DB04088]

Heme D
Heme D [drugbank:DB03469]

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
Dinoprostone
Dinoprostone [drugbank:DB00917]

Mitiglinide is a drug for the treatment of type 2 diabetes .Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells.
Mitiglinide
Mitiglinide [drugbank:DB01252]

N-Hexylphosphonate Ethyl Ester
N-Hexylphosphonate Ethyl Ester [drugbank:DB04321]

AST-120 is an orally administered adsorbent used to slow the progression of chronic kidney disease (CKD).
AST-120
AST-120 [drugbank:DB05269]

N-Propyl Isocyanide
N-Propyl Isocyanide [drugbank:DB04050]

A substance that is being studied in the prevention of oral mucositis in patients receiving radiation therapy or chemotherapy for head and neck cancer. It is an oral polymer matrix-based rinse formulation that contains N-acetylcysteine, an antioxidant amino acid derivative with antiinflammatory properties.
RK-0202 [drugbank:DB05436]

N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide
N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide [drugbank:DB02647]

(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
(5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE [drugbank:DB08293]

A muscarinic antagonist used as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. [PubChem]
Dicyclomine
Dicyclomine [drugbank:DB00804]

Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.
Piboserod
Piboserod [drugbank:DB04873]

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Epoprostenol
Epoprostenol [drugbank:DB01240]

SR12813 [drugbank:DB04466]

R115777 is a substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors. It is also called tipifarnib and Zarnestra.
R115777 [drugbank:DB04960]

8-Hydroxy-4-(1-Hydroxyethyl)Quinoline-2-Carboxylic Acid
8-Hydroxy-4-(1-Hydroxyethyl)Quinoline-2-Carboxylic Acid [drugbank:DB02566]

Ursodeoxycholic acid is an epimer of chenodeoxycholic acid (DB06777). It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. [PubChem]
Ursodeoxycholic acid
Ursodeoxycholic acid [drugbank:DB01586]

A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. [PubChem]
Menadione
Menadione [drugbank:DB00170]

4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID [drugbank:DB07320]

Cyclohexane Propionic Acid
Cyclohexane Propionic Acid [drugbank:DB02242]

2-{(9as)-9a-[(1s)-1-Hydroxyethyl]-2,7-Dimethyl-9a,10-Dihydro-5h-Pyrimido[4,5-D][1,3]Thiazolo[3,2-a]Pyrimidin-8-Yl}Ethyl Trihydrogen Diphosphate
2-{(9as)-9a-[(1s)-1-Hydroxyethyl]-2,7-Dimethyl-9a,10-Dihydro-5h-Pyrimido[4,5-D][1,3]Thiazolo[3,2-a]Pyrimidin-8-Yl}Ethyl Trihydrogen Diphosphate [drugbank:DB03361]

Coenzyme a Persulfide
Coenzyme a Persulfide [drugbank:DB04036]

{[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID
{[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID [drugbank:DB08098]

Gemcitabine is a nucleoside analog used as chemotherapy. It is marketed as GemzarÂ® by Eli Lilly and Company. As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the "faulty" nucleoside, resulting in apoptosis (cellular "suicide"). Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It is being investigated for use in oesophageal cancer, and is used experimentally in lymphomas and various other tumor types.
Gemcitabine
Gemcitabine [drugbank:DB00441]

1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE
1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE [drugbank:DB07846]

AVE-1625 is an oral selective and potent antagonist of cannabinoid 1 (CB1) receptors having the same mechanism of action as rimonabant. It is currently developed in obesity and its associated comorbidities. AVE-1625 is also being developed for the treatment of Alzheimer disease.
AVE-1625
AVE-1625 [drugbank:DB05750]

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
Inosine
Inosine [drugbank:DB04335]

Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients with refractory epilepsy. FDA approved in June 10, 2011 under the name of ezogabine.
Ezogabine
Ezogabine [drugbank:DB04953]

The botanical drug product LLL-3348 is a once-daily oral formulation for treatment of chronic stable plaque type psoriasis.
LLL-3348
LLL-3348 [drugbank:DB05771]

ISV-403 combines a fourth-generation fluoroquinolone, SS734, licensed from Japan's SSP, Co., Ltd., with InSite Vision's patented drug delivery system, DuraSite(R). Preclinical studies with ISV-403 indicated that this drug candidate is effective against bacteria resistant to third generation fluoroquinolone products.
ISV-403
ISV-403 [drugbank:DB05862]

An antilipemic agent which reduces both cholesterol and triglycerides in the blood. [PubChem]
Fenofibrate
Fenofibrate [drugbank:DB01039]

AI-850 is a Cremophor(R)-free formulation of paclitaxel, the active ingredient in Taxol(R), a product used to treat a variety of solid tumors.
AI-850
AI-850 [drugbank:DB05842]

A xanthine oxidase inhibitor that decreases uric acid production. It also acts as an antimetabolite on some simpler organisms. [PubChem]
Allopurinol
Allopurinol [drugbank:DB00437]

N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide
N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide [drugbank:DB07946]

RAV12 is a monoclonal antibody that is being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. It binds to a carbohydrate (sugar) molecule that is found on gastric, colon, pancreatic, prostate, ovarian, breast, and kidney cancer cells.
RAV12
RAV12 [drugbank:DB05140]

(1S)-MENTHYL HEXYL PHOSPHONATE GROUP
(1S)-MENTHYL HEXYL PHOSPHONATE GROUP [drugbank:DB08201]

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. [PubChem]
Edetic Acid
Edetic Acid [drugbank:DB00974]

3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE
3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE [drugbank:DB07802]

A pyrrolidinylmethyl tetracycline. [PubChem]
Rolitetracycline
Rolitetracycline [drugbank:DB01301]

Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine, a class of molecules that resemble pyrimidine nucleotides found in DNA. Because of its flexible chemical structure, resistance of rilpivirine is less likely to develop than other NNRTI's. FDA approved on May 20, 2011.
Rilpivirine
Rilpivirine [drugbank:DB08864]

2-aminoethyl naphthalen-1-ylacetate
2-aminoethyl naphthalen-1-ylacetate [drugbank:DB08115]

2,2':6',2''-Terpyridine Platinum(Ii)
2,2':6',2''-Terpyridine Platinum(Ii) [drugbank:DB01912]

4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID [drugbank:DB07130]

N-ACETYLHISTAMINE
N-ACETYLHISTAMINE [drugbank:DB04622]

Sodium hyaluronate is the sodium salt of hyaluronan. The term hyaluronate also refers to the conjugate base of hyaluronic acid. Because the molecule typically exists in vivo in its polyanionic form, it is most commonly referred to as hyaluronan. It is a visco-elastic polymer normally found in the aqueous and vitreous humour. Sodium hyaluronate is a viscous solution consisting of a high molecular weight (500,000-730,000 daltons) fraction of purified natural sodium hyaluronate in buffered physiological sodium chloride. Hyaluronic acid is a natural complex sugar of the glycosaminoglycan family and is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine. Sodium hyaluronate occurs naturally on the corneal endothelium, bound to specific receptors for which it has a high affinity.
Hyaluronan
Hyaluronan [drugbank:DB08818]

Carfentanil
Carfentanil [drugbank:DB01535]

4-hydroxycoumarin
4-hydroxycoumarin [drugbank:DB03410]

5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine
5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine [drugbank:DB08234]

(S)-2-(MERCAPTOMETHYL)-5-PHENYLPENTANOIC ACID
(S)-2-(MERCAPTOMETHYL)-5-PHENYLPENTANOIC ACID [drugbank:DB08161]

3h-Indole-5,6-Diol
3h-Indole-5,6-Diol [drugbank:DB01811]

A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. [PubChem]
Dobutamine
Dobutamine [drugbank:DB00841]

N-Naphthalen-1-Ylmethyl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine
N-Naphthalen-1-Ylmethyl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine [drugbank:DB03331]

Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.
Sodium lauryl sulfate
Sodium lauryl sulfate [drugbank:DB00815]

N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE [drugbank:DB07520]

(4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
(4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile [drugbank:DB08166]

(2S)-2-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-PHENYL-N-PYRIDIN-4-YLACETAMIDE
(2S)-2-[(2,1,3-BENZOTHIADIAZOL-4-YLSULFONYL)AMINO]-2-PHENYL-N-PYRIDIN-4-YLACETAMIDE [drugbank:DB07568]

RHIIP is a powder form of recombinant insulin for inhalation administration. It is being developed by Baxter Healthcare Corporation.
RHIIP
RHIIP [drugbank:DB05215]

Bevirimat is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. It is not currently FDA-approved, but is undergoing clinical trials conducted by the pharmaceutical company Panacos.
Bevirimat
Bevirimat [drugbank:DB06581]

Tmr
Tmr [drugbank:DB03903]

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Formaldehyde
Formaldehyde [drugbank:DB03843]

1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine [drugbank:DB08054]

1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide [drugbank:DB06896]

Aliskiren is a renin inhibitor. It was approved by the U.S. Food and Drug Administration in 2007 for the treatment of hypertension.
Aliskiren
Aliskiren [drugbank:DB01258]

Alizapride is a dopamine antagonist with prokinetic and antiemetic effects used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
Alizapride
Alizapride [drugbank:DB01425]

AUROVERTIN B
AUROVERTIN B [drugbank:DB07394]

1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine
1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine [drugbank:DB07555]

Adenosine-5'-Diphosphate Monothiophosphate
Adenosine-5'-Diphosphate Monothiophosphate [drugbank:DB01660]

Buprenorphine is a derivative of the opioid alkaloid thebaine that is a more potent (25 - 40 times) and longer lasting analgesic than morphine. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use. [PubChem]
Buprenorphine
Buprenorphine [drugbank:DB00921]

1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE
1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE [drugbank:DB06869]

(3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide
(3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide [drugbank:DB08305]

BRX-235 (iroxanadine) is a a novel small molecule synthesized by Biorex, Hungary that acts as a cardioprotective agent. It induces phosphorylation of p38 SAPK, which plays an important role in EC homeostasis. endothelial cell (EC). EC function plays a central role in vascular diseases (e.g. atherosclerosis, restenosis, diabetic angiopathies, microvascular angina, peripheral arterial disease). BRX-235 also causes translocation of calcium-dependent protein kinase C isoform to membranes.
BRX-235
BRX-235 [drugbank:DB05444]

Quinaldic Acid
Quinaldic Acid [drugbank:DB02428]

4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE
4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE [drugbank:DB08764]

PM02734 is a marine derived compound. PM02734 as a new antiproliferative drug demonstrating activity against a broad spectrum of tumor types: breast, colon, pancreas, lung and prostate, among others.
PM02734 [drugbank:DB05158]

D-Myo-Inositol-2,4,5-Trisphosphate
D-Myo-Inositol-2,4,5-Trisphosphate [drugbank:DB03956]

2',4,4'-Trihydroxychalcone
2',4,4'-Trihydroxychalcone [drugbank:DB03285]

2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE
2-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDE [drugbank:DB08184]

An analogue of gamma-aminobutyric acid, vigabatrin is an irreversible inhibitor of 4-aminobutyrate transaminase, the enzyme responsible for the catabolism of gamma-aminobutyric acid. (From Martindale The Extra Pharmacopoeia, 31st ed). Off-label uses include treatment of cocaine dependence.
Vigabatrin
Vigabatrin [drugbank:DB01080]

Propylhexedrine is an alpha-adrenergic agonist often used in nasal decongestant inhalers. It is used to give temporary relief for nasal congestion from colds, allergic rhinitis, or allergies.
Propylhexedrine
Propylhexedrine [drugbank:DB06714]

Hexafluoroacetone Hydrate
Hexafluoroacetone Hydrate [drugbank:DB02922]

Didecyl-Dimethyl-Ammonium
Didecyl-Dimethyl-Ammonium [drugbank:DB04221]

VLTS-589 consists of plasmid encoding the angiomatrix protein Del-1 in conjunction with poloxamer 188 for the treatment of peripheral vascular disease.
VLTS-589
VLTS-589 [drugbank:DB05430]

5-(5-(6-CHLORO-4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)PENTYL)-3-METHYL ISOXAZOLE
5-(5-(6-CHLORO-4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)PENTYL)-3-METHYL ISOXAZOLE [drugbank:DB08719]

N-(R-Carboxy-Ethyl)-Alpha-(S)-(2-Phenylethyl)Glycyl-L-Arginine-N-Phenylamide
N-(R-Carboxy-Ethyl)-Alpha-(S)-(2-Phenylethyl)Glycyl-L-Arginine-N-Phenylamide [drugbank:DB02747]

is an experimental therapeutic vaccine currently in clinical trial. The aim of therapeutic vaccines is to augment the body's immune response to HIV and to delay or prevent progression to AIDS.
VIR201
VIR201 [drugbank:DB05110]

MLN8237 is a novel aurora A kinase inhibitor under investigation for the treatment of various forms of cancer.
MLN8237
MLN8237 [drugbank:DB05220]

P-Hydroxybenzoic Acid
P-Hydroxybenzoic Acid [drugbank:DB04242]

(1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE
(1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE [drugbank:DB07349]

N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide [drugbank:DB07738]

6-(cyclohexylsulfanyl)-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1H,3H)-dione
6-(cyclohexylsulfanyl)-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1H,3H)-dione [drugbank:DB07184]

3,4-Methylenedioxy-N-ethylamphetamine
3,4-Methylenedioxy-N-ethylamphetamine [drugbank:DB01566]

6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One
6-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-One [drugbank:DB02918]

CRA_7806
CRA_7806 [drugbank:DB01725]

Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior.
Deserpidine
Deserpidine [drugbank:DB01089]

Methyprylon is a sedative of the piperidinedione derivative family. This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with less side effects, such as benzodiazepines. Methyprylon was withdrawn from the US market in June 1965 and the Canadian market in September 1990. [Wikipedia]
Methyprylon
Methyprylon [drugbank:DB01107]

Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.

It is also known by the brand name of Xalatan manufactured by Pfizer.

Latanoprost
Latanoprost [drugbank:DB00654]

4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine
4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine [drugbank:DB02091]

ALS-357 is a novel drug entering phase I/II clinical development that has demonstrated potent anti-tumor activity against malignant melanoma. ALS-357 has shown promise in both in vitro and in vivo preclinical studies. Rapid tumor regression has been shown in a mouse model and no observable toxicity was seen even at high doses.
ALS-357
ALS-357 [drugbank:DB05910]

Trametinib dimethyl sulfoxide is a kinase inhibitor. Each 1-mg tablet contains 1.127 mg trametinib dimethyl sulfoxide equivalent to 1 mg of trametinib non-solvated parent. FDA approved on May 29, 2013.
Trametinib
Trametinib [drugbank:DB08911]

3-chloro-5-[2-chloro-5-(1H-indazol-3-ylmethoxy)phenoxy]benzonitrile
3-chloro-5-[2-chloro-5-(1H-indazol-3-ylmethoxy)phenoxy]benzonitrile [drugbank:DB08154]

CRA_9076
CRA_9076 [drugbank:DB04215]

(2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL
(2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL [drugbank:DB07037]

2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid
2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid [drugbank:DB03683]

N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-
N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}- [drugbank:DB04579]

LM-609 (Vitaxin) is an artificial antibody that targets a protein on the surface of newly forming blood vessels, as well as on certain tumors. In addition to cancer, the protein has been implicated in bone destruction in rheumatoid arthritis and the inflammatory process in psoriasis.
LM-609
LM-609 [drugbank:DB05787]

A benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable. [PubChem]
Indapamide
Indapamide [drugbank:DB00808]

4-Guanidinobenzoic Acid
4-Guanidinobenzoic Acid [drugbank:DB02459]

One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. [PubChem]
Pyrimethamine
Pyrimethamine [drugbank:DB00205]

(2s,3r)-1-Amino-2-Methylbutane-2,3-Diol
(2s,3r)-1-Amino-2-Methylbutane-2,3-Diol [drugbank:DB02847]

(4s,5s)-1,2-Dithiane-4,5-Diol [drugbank:DB02693]

5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE
5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE [drugbank:DB08230]

An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem]
Guanabenz
Guanabenz [drugbank:DB00629]

(2S,3S)-3-(4-fluorophenyl)-2,3-dihydroxypropanoic acid
(2S,3S)-3-(4-fluorophenyl)-2,3-dihydroxypropanoic acid [drugbank:DB06946]

METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER [drugbank:DB08413]

2-Acetyl-3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-4-Methyl-5-(4,6,6-Trihydroxy-3,5-Dioxa-4,6-Diphosphahex-1-Yl)Thiazolium Inner Salt P,P'-Dioxide
2-Acetyl-3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-4-Methyl-5-(4,6,6-Trihydroxy-3,5-Dioxa-4,6-Diphosphahex-1-Yl)Thiazolium Inner Salt P,P'-Dioxide [drugbank:DB02410]

Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised of approximately 35,000 patients. It was launched in the US in December 1994 and in Japan in June 1999. As of the end of 1995, more than 10 million patients worldwide have been treated with fluvoxamine.
Fluvoxamine
Fluvoxamine [drugbank:DB00176]

7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID
7-{2,6-DICHLORO-4-[3-(2-CHLORO-BENZOYL)-UREIDO]-PHENOXY}-HEPTANOIC ACID [drugbank:DB04642]

8-Benzyl-2-Hydroxy-2-(4-Hydroxy-Benzyl)-6-(4-Hydroxy-Phenyl)-2h-Imidazo[1,2-a]Pyrazin-3-One
8-Benzyl-2-Hydroxy-2-(4-Hydroxy-Benzyl)-6-(4-Hydroxy-Phenyl)-2h-Imidazo[1,2-a]Pyrazin-3-One [drugbank:DB02194]

6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL
6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL [drugbank:DB07820]

(5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
(5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE [drugbank:DB08292]

N-Methylmesoporphyrin
N-Methylmesoporphyrin [drugbank:DB01911]

Phenylalanine Amide
Phenylalanine Amide [drugbank:DB04029]

5'-[[2-(Aminooxy)Ethyl]Methylsulfonio]-5'-Deoxy-Adenosine
5'-[[2-(Aminooxy)Ethyl]Methylsulfonio]-5'-Deoxy-Adenosine [drugbank:DB02523]

Methylamine
Methylamine [drugbank:DB01828]

Phosphoric Acid Mono-[3,4-Dihydroxy-5-(5-Hydroxy-Benzoimidazol-1-Yl)Tetrahydro-Furan-2-Ylmethyl] Ester
Phosphoric Acid Mono-[3,4-Dihydroxy-5-(5-Hydroxy-Benzoimidazol-1-Yl)Tetrahydro-Furan-2-Ylmethyl] Ester [drugbank:DB02905]

Ambenonium is a cholinesterase inhibitor used in the management of myasthenia gravis. [Wikipedia]
Ambenonium
Ambenonium [drugbank:DB01122]

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)
Methylergometrine
Methylergometrine [drugbank:DB00353]

(2E,4E)-2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOIC ACID
(2E,4E)-2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOIC ACID [drugbank:DB07915]

MVA3000 is an attenuated smallpox vaccine that is being developed for use in people for whom the traditional smallpox vaccine is contraindicated, such as patients with disorders of the immune system or skin conditions such as eczema.
MVA3000
MVA3000 [drugbank:DB05040]

(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE
(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-2-{[(S)-(4-FLUOROPHENYL)(1H-TETRAZOL-5-YL)METHYL]AMINO}-1,3-THIAZOL-4(5H)-ONE [drugbank:DB08710]

3',5'-Dinitro-N-Acetyl-L-Thyronine
3',5'-Dinitro-N-Acetyl-L-Thyronine [drugbank:DB03239]

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. [PubChem]
Nicotinamide
Nicotinamide [drugbank:DB02701]

2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole
2-(Beta-D-Glucopyranosyl)-5-Methyl-1,2,3-Benzimidazole [drugbank:DB03133]

3-(BUTYLSULPHONYL)-PROPANOIC ACID
3-(BUTYLSULPHONYL)-PROPANOIC ACID [drugbank:DB07387]

Ticrynafen, or tienilic acid, is a diuretic drug with uric acid-lowering (uricosuric) action, formerly marketed for the treatment of hypertension. It was withdrawn in 1982, shortly after its introduction to the market, after case reports in the United States indicated a link between the use of ticrynafen and hepatitis. (Manier et al., 1982)
Ticrynafen
Ticrynafen [drugbank:DB04831]

A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent. [PubChem]
Deoxycholic Acid
Deoxycholic Acid [drugbank:DB03619]

AIR Epinephrine is an investigational inhaled dry powder formulation using Alkermes' AIR technology, which utilizes drug particles that can be delivered using small, simple inhalers.
AIR-Epinephrine
AIR-Epinephrine [drugbank:DB05878]

M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene
M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene [drugbank:DB03359]

AM103 is a novel inhibitor of 5-lipoxygenase-activiting protein (FLAP) that has demonstrated potential to treat asthma and cardiovascular disease by preventing the synthesis of LT, which triggers inflammation. It is being developed by Amira.
AM103
AM103 [drugbank:DB05225]

N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide [drugbank:DB06995]

The GnRH pharmaccine consists of synthetic peptides (constructed to "look like" GnRH), which are bound chemically to a carrier and suspended in a proprietary "delivery vehicle". The pharmaccine is administered intramuscularly to the patient by injection and induces an immune response or production of antibodies in the patient, which neutralize GnRH thus removing it from circulation.
GnRH pharmaccine
GnRH pharmaccine [drugbank:DB05815]

A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex.
Cosyntropin
Cosyntropin [drugbank:DB01284]

Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy (damage to or disease of the kidney).
Phenacetin
Phenacetin [drugbank:DB03783]

(2E)-3-{3-[(5-ETHYL-3-IODO-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-4-YL)OXY]PHENYL}ACRYLONITRILE
(2E)-3-{3-[(5-ETHYL-3-IODO-6-METHYL-2-OXO-1,2-DIHYDROPYRIDIN-4-YL)OXY]PHENYL}ACRYLONITRILE [drugbank:DB07035]

Personalized Immunotherapy is an investigational treatment based on the unique genetic makeup of a patient's tumor and is designed to activate a patient's immune system to identify and attack cancer cells. Personalized Immunotherapy is commonly referred to as a patient-specific or personalized immunotherapy, an active idiotype immunotherapy, or a patient-specific or personalized cancer vaccine.
personalized immunotherapy
personalized immunotherapy [drugbank:DB05397]

Furethidine
Furethidine [drugbank:DB01464]

3-Chlorophenol
3-Chlorophenol [drugbank:DB01957]

Troxacitabine (brand name Troxatyl) is a nucleoside analogue with anticancer activity. Its use is being studied in patients with refractory lymphoproliferative diseases.
Troxacitabine
Troxacitabine [drugbank:DB04961]

5-Iodouracil
5-Iodouracil [drugbank:DB03554]

9-Deazaadenine
9-Deazaadenine [drugbank:DB03506]

Beta-Hydroxytryptophane
Beta-Hydroxytryptophane [drugbank:DB04159]

2-Bromoacetyl Group
2-Bromoacetyl Group [drugbank:DB02198]

Dephospho Coenzyme A
Dephospho Coenzyme A [drugbank:DB03170]

CRx-139 is an oral synergistic combination drug candidates with novel mechanisms of action targeting multiple biological pathways simultaneously. It is a dissociated steroid designed to enhance the immuno-modulatory activity of a low-dose glucocorticoid steroid without a comparable increase in steroid-related side effects. The synergistic combination containing low doses of the glucocorticoid steroid prednisolone and the antidepressant paroxetine. This novel synergistic combination is developed for the treatment of immuno-inflammatory diseases.
CRx-139
CRx-139 [drugbank:DB05744]

The N-acetyl derivative of glucosamine. [PubChem]
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose [drugbank:DB03740]

3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL
3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL [drugbank:DB08309]

N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE [drugbank:DB07653]

Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company.

Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia.

Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake.

Duloxetine
Duloxetine [drugbank:DB00476]

Docetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel binds to microtubules reversibly with high affinity and has a maximum stoichiometry of one mole docetaxel per mole tubulin in microtubules.
Docetaxel
Docetaxel [drugbank:DB01248]

Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Nepafenac
Nepafenac [drugbank:DB06802]

Methylphosphonic Acid Ester Group
Methylphosphonic Acid Ester Group [drugbank:DB02825]

S-Arsonocysteine
S-Arsonocysteine [drugbank:DB03352]

Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Ponatinib
Ponatinib [drugbank:DB08901]

(R)-4-Nitrostyrene oxide
(R)-4-Nitrostyrene oxide [drugbank:DB04777]

3-Phosphoglyceric Acid
3-Phosphoglyceric Acid [drugbank:DB04510]

UBIQUINONE-1
UBIQUINONE-1 [drugbank:DB08689]

[2-Aminomethyl-5-Oxo-4-(4-Oxo-Cyclohexa-2,5-Dienylmethyl)-4,5-Dihydro-Imidazol-1-Yl] -Acetaldehyde
[2-Aminomethyl-5-Oxo-4-(4-Oxo-Cyclohexa-2,5-Dienylmethyl)-4,5-Dihydro-Imidazol-1-Yl] -Acetaldehyde [drugbank:DB02275]

A thiol-containing amino acid formed by a demethylation of METHIONINE. [PubChem]
2-Amino-4-Mercapto-Butyric Acid
2-Amino-4-Mercapto-Butyric Acid [drugbank:DB04422]

A topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration. [PubChem]
Dequadin
Dequadin [drugbank:DB04209]

Ethyl carbamate (also known as urethan and urethane), formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
Ethyl carbamate
Ethyl carbamate [drugbank:DB04827]

1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE
1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE [drugbank:DB07593]

PRLX 93936 is selectively toxic to cancer cells.
PRLX 93936
PRLX 93936 [drugbank:DB06098]

4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE [drugbank:DB07227]

TAK-491 is an investigational compound developed by Japanese pharmaceutical company, Takeda for the treatment of hypertension.
TAK-491
TAK-491 [drugbank:DB05358]

N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE [drugbank:DB07589]

SPL7013 is a lysine-based dendrimer with naphthalene disulfonic acid surface groups. It is the active ingredient of VivaGel, a water-based vaginal microbicide gel.
SPL-7013
SPL-7013 [drugbank:DB05658]

(5-BROMO-4-CHLORO-3-INDOLYL)-A-D-MANNOSE
(5-BROMO-4-CHLORO-3-INDOLYL)-A-D-MANNOSE [drugbank:DB04806]

Acadesine (AICA-riboside) is a purine nucleoside analog with anti-ischemic properties that is currently being studied (Phase 3) for the prevention of adverse cardiovascular outcomes in patients undergoing coronary artery bypass graft (CABG) surgery. It is being developed jointly by PeriCor and Schering-Plough. Acadesine has been granted Orphan Drug Designation for B-CLL in the EU.
Acadesine
Acadesine [drugbank:DB04944]

(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE [drugbank:DB07717]

DECYL FORMATE
DECYL FORMATE [drugbank:DB07650]

HD-O is an amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
HD-O
HD-O [drugbank:DB05891]

4-CHLORO-3',3''-DIBROMOPHENOL-1,8-NAPHTHALEIN
4-CHLORO-3',3''-DIBROMOPHENOL-1,8-NAPHTHALEIN [drugbank:DB04696]

Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
Antithymocyte globulin
Antithymocyte globulin [drugbank:DB00098]

7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE [drugbank:DB07248]

PD173955 [drugbank:DB02567]

1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANE
1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANE [drugbank:DB04771]

A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. [PubChem]
Cephalexin
Cephalexin [drugbank:DB00567]

1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane
1-(2-Methoxy-Ethoxy)-2-{2-[2-(2-Methoxy-Ethoxy]-Ethoxy}-Ethane [drugbank:DB02580]

S-4-Nitrobutyryl-Coa
S-4-Nitrobutyryl-Coa [drugbank:DB03245]

Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent.
Chlorphenoxamine
Chlorphenoxamine [drugbank:DB09007]

(2S)-2-HYDROXYOCTANOIC ACID
(2S)-2-HYDROXYOCTANOIC ACID [drugbank:DB07907]

(2s)-2-[(5-Benzofuran-2-Yl-Thiophen-2-Ylmethyl)-(2,4-Dichloro-Benzoyl)-Amino]-3-Phenyl-Propionic Acid
(2s)-2-[(5-Benzofuran-2-Yl-Thiophen-2-Ylmethyl)-(2,4-Dichloro-Benzoyl)-Amino]-3-Phenyl-Propionic Acid [drugbank:DB02331]

An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. [PubChem]
Phenoxybenzamine
Phenoxybenzamine [drugbank:DB00925]

Oprelvekin, the active ingredient in NeumegaÂ® is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo.

The primary hematopoietic activity of NeumegaÂ® is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies NeumegaÂ® has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, NeumegaÂ® improved platelet nadirs and accelerated platelet recoveries compared to controls.

In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines.

Oprelvekin
Oprelvekin [drugbank:DB00038]

GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive rights to the compound and a related library of analogs as part of the acquisition of Osprey Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study in healthy adults, GTS-21 also demonstrated cognitive enhancement across all doses, with a statistically significant improvement in attention related and memory related tasks (Kitagawa, et al. Neuropsychopharmacology (2003), 28, 542-551).
GTS-21
GTS-21 [drugbank:DB05708]

3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione [drugbank:DB01772]

(S)-ATPA
(S)-ATPA [drugbank:DB03319]

1-ACETYL-2-LYSO-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
1-ACETYL-2-LYSO-SN-GLYCERO-3-PHOSPHOETHANOLAMINE [drugbank:DB04731]

3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium
3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium [drugbank:DB03005]

(1s,6s,7r,8r,8ar)-1,6,7,8-Tetrahydroxyindolizidine
(1s,6s,7r,8r,8ar)-1,6,7,8-Tetrahydroxyindolizidine [drugbank:DB01816]

3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE
3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE [drugbank:DB08730]

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Cytarabine
Cytarabine [drugbank:DB00987]

A ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with naphthoquinones it acts as a sunscreening agent. [PubChem]
Dihydroxyacetone
Dihydroxyacetone [drugbank:DB01775]

Bis(5-Amidino-Benzimidazolyl)Methane
Bis(5-Amidino-Benzimidazolyl)Methane [drugbank:DB01705]

Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.
Tizanidine
Tizanidine [drugbank:DB00697]

Para-Isopropylaniline
Para-Isopropylaniline [drugbank:DB02114]

2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE [drugbank:DB06843]

R673 is a novel NK1 antagonist that penetrates the blood-brain barrier, has excellent safety and tolerability and shows low P450-based drug interaction potential. The phase II program for treatment of depression and anxiety is ongoing in the US and EU.It is not clear how tachykinin antagonists exert their effect, but SP levels have been commonly linked to the functioning of limbic system with respect to anxiety and depression.
R673 [drugbank:DB05466]

REN-850 is an oral drug for multiple sclerosis which is in Phase I of clinical trials.
REN-850
REN-850 [drugbank:DB05912]

A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection. [PubChem]
Levorphanol
Levorphanol [drugbank:DB00854]

2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE
2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE [drugbank:DB07529]

Gamma Hydroxybutyric Acid, commonly abbreviated GHB, is a therapeutic drug which is illegal in multiple countries. It is currently regulated in the US and sold by Jazz Pharmaceuticals under the name Xyrem. However, it is important to note that GHB is a designated Orphan drug (in 1985). Today Xyrem is a Schedule III drug; however GHB remains a Schedule I drug and the illicit use of Xyrem falls under penalties of Schedule I. GHB is a naturally occurring substance found in the central nervous system, wine, beef, small citrus fruits and almost all other living creatures in small amounts. It is used illegally under the street names Juice, Liquid Ecstasy or simply G, either as an intoxicant, or as a date rape drug. Xyrem is a central nervous system depressant that reduces excessive daytime sleepiness and cataplexy in patients with narcolepsy.
Gamma Hydroxybutyric Acid
Gamma Hydroxybutyric Acid [drugbank:DB01440]

An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. [PubChem]
Idarubicin
Idarubicin [drugbank:DB01177]

3-Deazacytidine
3-Deazacytidine [drugbank:DB04385]

RIGScan CR49, a 125I-labelled CR monoclonal antibody directed against the tumour-associated antigen TAG-72, is undergoing development with Neoprobe for the intraoperative detection of metastatic colorectal cancer.
RIGScan CR49
RIGScan CR49 [drugbank:DB05437]

Phenolphthalein was withdrawn in Canada due to concerns with carcinogenicity in 1997.
Phenolphthalein
Phenolphthalein [drugbank:DB04824]

A phosphodiesterase inhibitor with antidepressant properties. [PubChem]
4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone
4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone [drugbank:DB01954]

Alpha-Benzyl-Aminobenzyl-Phosphonic Acid
Alpha-Benzyl-Aminobenzyl-Phosphonic Acid [drugbank:DB03577]

L-2-Amino-4-(Guanidinooxy)Butyric Acid
L-2-Amino-4-(Guanidinooxy)Butyric Acid [drugbank:DB01833]

L-Tyrosinamide
L-Tyrosinamide [drugbank:DB03380]

N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide [drugbank:DB07316]

4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE
4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE [drugbank:DB08495]

3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE
3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE [drugbank:DB08091]

3-[(1s)-1-(Dimethylamino)Ethyl]Phenol
3-[(1s)-1-(Dimethylamino)Ethyl]Phenol [drugbank:DB04556]

Elesclomol is a novel, injectable, drug candidate that kills cancer cells by elevating oxidative stress levels beyond a breaking point, triggering programmed cell death. In preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high doses, and an ability to strongly enhance the efficacy of certain chemotherapy agents, with minimal additional toxicity, at moderate doses. It is being developed by Synta Pharmaceuticals.
Elesclomol
Elesclomol [drugbank:DB05719]

N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine [drugbank:DB08055]

3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA
3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA [drugbank:DB08095]

{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID
{5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID [drugbank:DB08232]

4-Hydroxy-3-Methyl Butyl Diphosphate
4-Hydroxy-3-Methyl Butyl Diphosphate [drugbank:DB01799]

2,5-Xylidine
2,5-Xylidine [drugbank:DB02163]

A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)
Diethylstilbestrol
Diethylstilbestrol [drugbank:DB00255]

4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile [drugbank:DB07421]

Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Perindopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.
Perindopril
Perindopril [drugbank:DB00790]

A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols. [PubChem]
(2s,3s)-1,4-Dimercaptobutane-2,3-Diol
(2s,3s)-1,4-Dimercaptobutane-2,3-Diol [drugbank:DB02184]

Reidispongiolide A
Reidispongiolide A [drugbank:DB04774]

A beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor. [PubChem]
Timolol
Timolol [drugbank:DB00373]

Tatp
Tatp [drugbank:DB01763]

1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE
1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE [drugbank:DB08357]

Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginseng's efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex and difficult to isolate. Rb1 appears to be most abundant in Panax quinquefolius (American Ginseng). Rb1 seems to affect the reproductive system in animal testicles. Recent research shows that Rb1 affects rat embryo development and has teratogenic effects, causing birth defects. Another study shows that Rb1 may increase testosterone production in male rats indirectly through the stimulation of the luteinizing hormone. Traditional Chinese medicine asserts that Panax quinquefolius promotes yin in the body. It also inhibits chemoinvasion and angiogenesis.
ginsenoside Rb1
ginsenoside Rb1 [drugbank:DB06749]

An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]
L-Phenylalanine
L-Phenylalanine [drugbank:DB00120]

N-[2(S)-Cyclopentyl-1(R)-Hydroxy-3(R)Methyl]-5-[(2(S)-Tertiary-Butylamino-Carbonyl)-4-(N1-(2)-(N-Methylpiperazinyl)-3-Chloro-Pyrazinyl-5-Carbonyl)-Piperazino]-4(S)-Hydroxy-2(R)-Phenylmethyl-Pentanamide
N-[2(S)-Cyclopentyl-1(R)-Hydroxy-3(R)Methyl]-5-[(2(S)-Tertiary-Butylamino-Carbonyl)-4-(N1-(2)-(N-Methylpiperazinyl)-3-Chloro-Pyrazinyl-5-Carbonyl)-Piperazino]-4(S)-Hydroxy-2(R)-Phenylmethyl-Pentanamide [drugbank:DB02785]

Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.
Beraprost
Beraprost [drugbank:DB05229]

4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE [drugbank:DB08521]

(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE [drugbank:DB07264]

3,3-Dichloro-2-Phosphonomethyl-Acrylic Acid
3,3-Dichloro-2-Phosphonomethyl-Acrylic Acid [drugbank:DB04317]

4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide
4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide [drugbank:DB07625]

Thionicotinamide-Adenine-Dinucleotide
Thionicotinamide-Adenine-Dinucleotide [drugbank:DB03893]

N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane [drugbank:DB02979]

Triethyl Phosphate
Triethyl Phosphate [drugbank:DB03347]

1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine [drugbank:DB08052]

(2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID
(2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID [drugbank:DB08641]

7,8-Dihydro-L-Biopterin
7,8-Dihydro-L-Biopterin [drugbank:DB03271]

A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [PubChem]
Cyproheptadine
Cyproheptadine [drugbank:DB00434]

Ephedra is an alkaloid chemical compound traditionally obtained from the plant Ephedra sinica. The sale of ephedra-containing supplements was banned in the United States in 2004. The drug is still sold in Canada in OTC formulations.
Ephedra
Ephedra [drugbank:DB01363]

4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL
4,4'-BIS([H]METHYLSULFONYL)-2,2',5,5'-TETRACHLOROBIPHENYL [drugbank:DB08373]

BIA
BIA [drugbank:DB03336]

[4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
[4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone [drugbank:DB08778]

(1S)-1-AMINO-2-(1H-INDOL-3-YL)ETHANOL
(1S)-1-AMINO-2-(1H-INDOL-3-YL)ETHANOL [drugbank:DB08649]

Clobutinol is a cough suppressant that is withdrawn from the US and EU markets. Studies in 2004 had indicated that clobutinol has the potential to prolong the QT interval. In 2007, Clobutinol was determined to cause cardiac arrhythmia in some patients.
Clobutinol
Clobutinol [drugbank:DB09004]

G207 is cancer-killing viruses, so-called oncolytic viruses, for the treatment of various forms of cancer developed by MediGene AG. These viruses are specific herpes simplex viruses, or HSVs, generally known as the cause of cold sores. MediGene uses these viruses, however, in a modified and "disarmed" form in order to make them utilizable as a therapeutic agent in humans.
G207 [drugbank:DB05827]

Trans-O-Hydroxy-Alpha-Methyl Cinnamate
Trans-O-Hydroxy-Alpha-Methyl Cinnamate [drugbank:DB01662]

4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine
4-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-Benzamidine [drugbank:DB02354]

Rufinamide is a triazole derivative and an anticonvulsant medication to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. Clinical trials suggest its efficacy in the treatment of partial seizures.
Rufinamide
Rufinamide [drugbank:DB06201]

The 3-cyclopentyl ether of ethinyl estradiol.
Quinestrol
Quinestrol [drugbank:DB04575]

2-(11-{2-[Benzenesulfonyl-(3-Methyl-Butyl)-Amino]-1-Hydroxy-Ethyl}-6,9-Dioxo-2-Oxa-7,10-Diaza-Bicyclo[11.2.2]Heptadeca-1(16),13(17),14-Trien-8-Yl)-Acetamide, Inhibitor 2
2-(11-{2-[Benzenesulfonyl-(3-Methyl-Butyl)-Amino]-1-Hydroxy-Ethyl}-6,9-Dioxo-2-Oxa-7,10-Diaza-Bicyclo[11.2.2]Heptadeca-1(16),13(17),14-Trien-8-Yl)-Acetamide, Inhibitor 2 [drugbank:DB02411]

RP101 is targeted at preventing tumor cells from developing resistance to chemotherapy, one of the most challenging areas facing oncologists. RP101 would be used as a co-treatment with cytostatic drugs to give a broader range of chemotherapy treatment options, thereby extending survival periods and improving quality of life for the cancer patients.
RP101
RP101 [drugbank:DB05041]

octyl 3-amino-3-deoxy-2-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-galactopyranoside
octyl 3-amino-3-deoxy-2-O-(2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-galactopyranoside [drugbank:DB07341]

Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
Chlorcyclizine
Chlorcyclizine [drugbank:DB08936]

N-2-Thiophen-2-Yl-Acetamide Boronic Acid
N-2-Thiophen-2-Yl-Acetamide Boronic Acid [drugbank:DB02094]

2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE
2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE [drugbank:DB08208]

Valpromide
Valpromide [drugbank:DB04165]

3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL [drugbank:DB07344]

3-{[(3-NITROANILINE]SULFONYL}THIOPHENE-2-CARBOXYLIC ACID
3-{[(3-NITROANILINE]SULFONYL}THIOPHENE-2-CARBOXYLIC ACID [drugbank:DB08306]

Analogue of Indinavir Drug
Analogue of Indinavir Drug [drugbank:DB01721]

Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Fosamprenavir
Fosamprenavir [drugbank:DB01319]

S-(4-BROMOBENZYL)CYSTEINE
S-(4-BROMOBENZYL)CYSTEINE [drugbank:DB08370]

1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA [drugbank:DB08043]

An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. [PubChem]
Streptozocin
Streptozocin [drugbank:DB00428]

M40403 is a low molecular weight, synthetic manganese containing superoxide dismutase mimetic (SODm) that selectively removes superoxide anion.
M40403 [drugbank:DB04976]

5-Bromothienyldeoxyuridine
5-Bromothienyldeoxyuridine [drugbank:DB03804]

3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME [drugbank:DB08334]

3-[Isopropyl(4-Methylbenzoyl)Amino]-5-Phenylthiophene-2-Carboxylic Acid
3-[Isopropyl(4-Methylbenzoyl)Amino]-5-Phenylthiophene-2-Carboxylic Acid [drugbank:DB03647]

Etofibrate is a fibrate. It is a combination of clofibrate and niacin, linked together by an ester bond. In the body, clofibrate and niacin separate and are released gradually, in a manner similar to controlled-release formulations.
Etofibrate
Etofibrate [drugbank:DB08983]

Skeletal Targeted Radiotherapy (STRâ¢) is designed to be used in combination with high-dose chemotherapy producing a direct therapeutic effect on the tumor sites in the bone plus a general bone-marrow effect to destroy myeloma cells in the bone marrow. It is an experimental therapy that is being developed by NeoRx Corporation.The scientific name of the drug is 166Ho-DOTMP.
Skeletal targeted radiotherapy
Skeletal targeted radiotherapy [drugbank:DB05380]

keyhole limpet hemocyanin is an immune modulators, given as a vaccine to help the body respond to cancer. A natural protein isolated from the marine mollusc keyhole limpet. Keyhole limpet hemocyanin is an immunogenic carrier protein that, in vivo, increases antigenic immune responses to haptens and other weak antigens such as idiotype proteins.
keyhole limpet hemocyanin
keyhole limpet hemocyanin [drugbank:DB05299]

An ester of testosterone with a propionate substitution at the 17-beta position. [PubChem]
Testosterone Propionate
Testosterone Propionate [drugbank:DB01420]

L-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID
L-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID [drugbank:DB08565]

FAMOXADONE
FAMOXADONE [drugbank:DB07778]

Kaempherol
Kaempherol [drugbank:DB01852]

S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE [drugbank:DB07602]

TC-2403- 12 is a neuronal nicotinic receptor agonist derived from Targacept's library of compounds.
TC-2403-12 [drugbank:DB05855]

Histidyl-Adenosine Monophosphate
Histidyl-Adenosine Monophosphate [drugbank:DB04201]

Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes.
Butenafine
Butenafine [drugbank:DB01091]

4-[(METHYLSULFONYL)AMINO]BENZOIC ACID
4-[(METHYLSULFONYL)AMINO]BENZOIC ACID [drugbank:DB07114]

Oxtriphylline is the choline salt form of theophylline. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued. In the US, oxtriphylline is no longer available.
Oxtriphylline
Oxtriphylline [drugbank:DB01303]

Tissue plasminogen activator (tPA). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
Tenecteplase
Tenecteplase [drugbank:DB00031]

A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. [PubChem]
R-1,2-Propanediol
R-1,2-Propanediol [drugbank:DB02159]

A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. [PubChem]
Tolazoline
Tolazoline [drugbank:DB00797]

Spiro(2,4,6-Trinitrobenzene[1,2a]-2o',3o'-Methylene-Adenine-Triphosphate
Spiro(2,4,6-Trinitrobenzene[1,2a]-2o',3o'-Methylene-Adenine-Triphosphate [drugbank:DB02524]

2-Carboxypropyl-Coenzyme A
2-Carboxypropyl-Coenzyme A [drugbank:DB03117]

CDP323 is a small-molecule prodrug antagonist of the vascular cell adhesion molecule 1 (VCAM-1) binding to alpha4-integrins. It was originally developed by the British biopharmaceutical company Celltech plc. (now UCB S.A.) and is a putative new drug for oral treatment of multiple sclerosis.
CDP323
CDP323 [drugbank:DB05092]

4-tert-butyl-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide
4-tert-butyl-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide [drugbank:DB07097]

4-Carboxycinnamic Acid
4-Carboxycinnamic Acid [drugbank:DB02126]

Deoxyuridine-5'-Diphosphate
Deoxyuridine-5'-Diphosphate [drugbank:DB03413]

6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL
6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL [drugbank:DB08605]

A transdermal gel containing ethinyl estradiol and norelgestromin being investigated by Antares Pharma for use as a female contraceptive.
AP1081
AP1081 [drugbank:DB05233]

2-chloro-5-nitro-N-phenylbenzamide
2-chloro-5-nitro-N-phenylbenzamide [drugbank:DB07863]

(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine [drugbank:DB07007]

METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATE
METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATE [drugbank:DB07962]

1-O-[P-Nitrophenyl]-Beta-D-Galactopyranose
1-O-[P-Nitrophenyl]-Beta-D-Galactopyranose [drugbank:DB02632]

4-METHYL-N-{(5E)-5-[(5-METHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}BENZENESULFONAMIDE
4-METHYL-N-{(5E)-5-[(5-METHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}BENZENESULFONAMIDE [drugbank:DB08481]

HGTV43 is an anti-sense treatment designed to produce T cells that are genetically resistant to HIV infection. HGTV43 is one of a number of so-called 'gene transfer vectors' developed by the biotechnology company Enzo Biochem, Inc.
HGTV-43
HGTV-43 [drugbank:DB05807]

N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE
N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE [drugbank:DB04677]

Tetrabromo-2-Benzotriazole
Tetrabromo-2-Benzotriazole [drugbank:DB04462]

Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Clarithromycin
Clarithromycin [drugbank:DB01211]

Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. [Wikipedia]
Dofetilide
Dofetilide [drugbank:DB00204]

{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE
{(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE [drugbank:DB07488]

N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE
N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE [drugbank:DB07973]

6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine [drugbank:DB08144]

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
Etodolac
Etodolac [drugbank:DB00749]

Mupirocin (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. Mupirocin has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.
Mupirocin
Mupirocin [drugbank:DB00410]

Sucrose Octasulfate
Sucrose Octasulfate [drugbank:DB01901]

2'-Deoxymaltose
2'-Deoxymaltose [drugbank:DB03281]

4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One
4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One [drugbank:DB02507]

Isocitrate Calcium Complex
Isocitrate Calcium Complex [drugbank:DB01848]

9-(5,5-Difluoro-5-Phosphonopentyl)Guanine
9-(5,5-Difluoro-5-Phosphonopentyl)Guanine [drugbank:DB04260]

Cysteine-S-Acetamide
Cysteine-S-Acetamide [drugbank:DB02987]

DDP733 is an oral prokinetic drug which Dynogen is developing as a treatment for both Irritable Bowel Syndrome with constipation (IBS-c) and nocturnal gastroesophageal reflux disease (NGERD). It is a partial agonist of the serotonin type 3 receptor (5-HT3). Serotonin is a neurotransmitter that is known to be involved in the control of the gastrointestinal (GI) system. Preclinical studies of DDP733 established the compoundâs prokinetic properties (the ability to promote the motility of the GI tract).
DDP733
DDP733 [drugbank:DB05049]

(2S)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL
(2S)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL [drugbank:DB07751]

Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis (eczema). It is currently available as a topical cream, once marketed by Novartis, (however Galderma will be promoting the molecule in Canada in early 2007) under the trade name Elidel. [Wikipedia]
Pimecrolimus
Pimecrolimus [drugbank:DB00337]

Lanosterol
Lanosterol [drugbank:DB03696]

(2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID
(2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID [drugbank:DB07199]

Cysteine-Methylene-Carbamoyl-1,10-Phenanthroline
Cysteine-Methylene-Carbamoyl-1,10-Phenanthroline [drugbank:DB04437]

iCo-007 (formerly known as ISIS 13650) is a second generation antisense compound being developed by iCo for the treatment of various eye diseases caused by the formation of new blood vessels (angiogenesis) such as age-related macular degeneration (AMD) and diabetic retinopathy(DR).
iCo-007
iCo-007 [drugbank:DB05268]

Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.
Rasagiline
Rasagiline [drugbank:DB01367]

Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers. [PubChem]
Cyclohexanol
Cyclohexanol [drugbank:DB03703]

Brentuximag vedotin or AdcetrisÂ® is an antibody-drug conjugate that combines an anti-CD30 antibody and the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Brentuximag vedotin was approved in 2011, and in January 2012, the drug label was revised to include a boxed warning of progressive multifocal leukoencephalopathy and death following JC virus infection.
Brentuximab vedotin
Brentuximab vedotin [drugbank:DB08870]

A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)
Trimethyl Glycine
Trimethyl Glycine [drugbank:DB04455]

(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide
(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide [drugbank:DB07131]

(2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
(2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide [drugbank:DB07736]

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. [Wikipedia]
Silver sulfadiazine
Silver sulfadiazine [drugbank:DB05245]

GIBBERELLIN A4
GIBBERELLIN A4 [drugbank:DB07815]

2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE [drugbank:DB08180]

Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.
Drotrecogin alfa
Drotrecogin alfa [drugbank:DB00055]

N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE
N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE [drugbank:DB07526]

An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of serotonin receptors and an antagonist at others. [PubChem]
Dimethyltryptamine
Dimethyltryptamine [drugbank:DB01488]

An anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. (From Martindale, The Extra Pharmacopoeia, 30th ed)
Mesalazine
Mesalazine [drugbank:DB00244]

1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)-CYCLOHEXANE-1-CARBOXYLIC A CID
1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)-CYCLOHEXANE-1-CARBOXYLIC A CID [drugbank:DB04656]

METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE
METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL]AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE [drugbank:DB07689]

Methamphetamine is a psychostimulant and sympathomimetic drug. It is a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potential for addiction and abuse.
Methamphetamine
Methamphetamine [drugbank:DB01577]

An analog of inosine with a methylthio group replacing the hydroxyl group in the 6-position. [PubChem]
Methylthioinosine
Methylthioinosine [drugbank:DB02896]

5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-3-(1-PHENYLPROPYL)CYCLOOCTA[B]PYRAN-2-ONE
5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-3-(1-PHENYLPROPYL)CYCLOOCTA[B]PYRAN-2-ONE [drugbank:DB08686]

A direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]
Hydralazine
Hydralazine [drugbank:DB01275]

methyl [(1E,5R)-5-{(3S)-3-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate
methyl [(1E,5R)-5-{(3S)-3-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate [drugbank:DB08266]

Quazepam is a drug which is a benzodiazepine derivative. It induces impairment of motor function and has hypnotic properties. Quazepam is used to treat insomnia.
Quazepam
Quazepam [drugbank:DB01589]

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
Magnesium Sulfate
Magnesium Sulfate [drugbank:DB00653]

[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID [drugbank:DB08513]

Rolicyclidine (PCPy) is a dissociative anesthetic drug with hallucinogenic and sedative effects. Due to its similarity in effects to PCP, PCPy was placed into the Schedule I list of illegal drugs in the 1970s, although it has never been widely abused and is now little known.
Rolicyclidine
Rolicyclidine [drugbank:DB01549]

Acetamide
Acetamide [drugbank:DB02736]

2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC ACID
2-{[(4-CHLOROPHENOXY)ACETYL]AMINO}BENZOIC ACID [drugbank:DB07185]

Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem]
Natamycin
Natamycin [drugbank:DB00826]

5-BETA-ANDROSTANE-3,17-DIONE
5-BETA-ANDROSTANE-3,17-DIONE [drugbank:DB07375]

Decamethonium is a short acting depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. It is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor.
Decamethonium
Decamethonium [drugbank:DB01245]

BV4
BV4 [drugbank:DB02572]

3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL [drugbank:DB07708]

Hirulog
Hirulog [drugbank:DB02351]

bis(4-hydroxyphenyl)methanone
bis(4-hydroxyphenyl)methanone [drugbank:DB07635]

Etheno-Nad
Etheno-Nad [drugbank:DB02483]

(4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID
(4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID [drugbank:DB07068]

Aicar
Aicar [drugbank:DB01700]

3-Iodo-Benzyl Alcohol
3-Iodo-Benzyl Alcohol [drugbank:DB03339]

A naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid. [PubChem]
Selenocysteine
Selenocysteine [drugbank:DB02345]

SL017 formulated as a topical gel, has been combined with a widely available light source for permanent removal of unwanted hair and for treatment of actinic keratosis
SL017
SL017 [drugbank:DB05156]

Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam
Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam [drugbank:DB01922]

Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.
Diflorasone
Diflorasone [drugbank:DB00223]

2,3-Didehydroalanine
2,3-Didehydroalanine [drugbank:DB02688]

{4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid
{4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid [drugbank:DB04285]

One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer.
Lucanthone
Lucanthone [drugbank:DB04967]

(1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid
(1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid [drugbank:DB07189]

Filaminast is a phosphodiesterase 4 inhibitor (PDE4 inhibitor). As such, has potential in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Filaminast
Filaminast [drugbank:DB02660]

[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile [drugbank:DB07966]

N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE [drugbank:DB07997]

Palmitoleic Acid
Palmitoleic Acid [drugbank:DB04257]

Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci.
Streptokinase
Streptokinase [drugbank:DB00086]

A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
Clofazimine
Clofazimine [drugbank:DB00845]

Aluminium monostearate is an organic compound which is a salt of stearic acid and aluminium. It has the molecular formula Al(OH)2C18H35O2. It is also referred to as dihydroxyaluminium or dihydroxy(stearato)aluminium.

It is used to form gels in the packaging of pharmaceuticals, and in the preparation of colors for cosmetics. It is usually safe in commercial products, but aluminium may accumulate in the body.

Dihydroxyaluminium
Dihydroxyaluminium [drugbank:DB01375]

1-Anilino-8-Naphthalene Sulfonate
1-Anilino-8-Naphthalene Sulfonate [drugbank:DB04474]

An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of leucine. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels. [PubChem]
L-Isoleucine
L-Isoleucine [drugbank:DB00167]

N-Formylpiperidine
N-Formylpiperidine [drugbank:DB04113]

L-2-amino-3-butynoic acid
L-2-amino-3-butynoic acid [drugbank:DB04217]

2-Amino-3-[5-(Amino-Carboxy-Methyl)-2,3-Dihydro-Isoxazol-3-Ylsulfanyl]-Propionic Acid
2-Amino-3-[5-(Amino-Carboxy-Methyl)-2,3-Dihydro-Isoxazol-3-Ylsulfanyl]-Propionic Acid [drugbank:DB01974]

(2R,4S)-2-[(R)-BENZYLCARBAMOYL-PHENYLACETYL-METHYL]-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID
(2R,4S)-2-[(R)-BENZYLCARBAMOYL-PHENYLACETYL-METHYL]-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID [drugbank:DB07806]

Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate
Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate [drugbank:DB04523]

Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Everolimus
Everolimus [drugbank:DB01590]

A histamine H2 agonist used clinically to test gastric secretory function. [PubChem]
Betazole
Betazole [drugbank:DB00272]

Carglumic acid is an orphan drug used for the treatment of hyperammonaemia in patients with N-acetylglutamate synthase deficiency. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the bloodâbrain barrier and cause neurologic problems, cerebral edema, coma, and death. Carglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010.
Carglumic Acid
Carglumic Acid [drugbank:DB06775]

1-Beta-Ribofuranosyl-1,3-Diazepinone
1-Beta-Ribofuranosyl-1,3-Diazepinone [drugbank:DB03185]

Pyridoxine-5'-Phosphate
Pyridoxine-5'-Phosphate [drugbank:DB02209]

Proguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
Proguanil
Proguanil [drugbank:DB01131]

1-Hydroxyamine-2-Isobutylmalonic Acid
1-Hydroxyamine-2-Isobutylmalonic Acid [drugbank:DB02326]

A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin. [PubChem]
Neopterin
Neopterin [drugbank:DB02385]

Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid
Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid [drugbank:DB03982]

Fosmidomycin
Fosmidomycin [drugbank:DB02948]

An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
Sodium Tetradecyl Sulfate
Sodium Tetradecyl Sulfate [drugbank:DB00464]

4-Hydroxy-19-nortestosterone
4-Hydroxy-19-nortestosterone [drugbank:DB01500]

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Amphotericin B
Amphotericin B [drugbank:DB00681]

6-Aminohexyl-Uridine-C1,5'-Diphosphate
6-Aminohexyl-Uridine-C1,5'-Diphosphate [drugbank:DB02696]

5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE
5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE [drugbank:DB04769]

(1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE
(1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE [drugbank:DB07356]

Alpha-methylfentanyl
Alpha-methylfentanyl [drugbank:DB01557]

Dimenoxadol is an opioid analgesic which produces typical opioid effects such as analgesia and sedation. It is structurally similar to methadone and is a benzilic acid derivative. In the United States it is classified as a Schedule I controlled drug.
Dimenoxadol
Dimenoxadol [drugbank:DB01461]

(3-Chloro-4-Propoxy-Phenyl)-Acetic Acid
(3-Chloro-4-Propoxy-Phenyl)-Acetic Acid [drugbank:DB02773]

GW-501516 is a peroxisome proliferator-activator receptor-delta agonist for the potential treatment of dyslipidemia. It is developed by GlaxoSmithKline. This drug is in Phase II clinical trials .
GW 501516 [drugbank:DB05416]

AZD0947 is a K+ channel opener, which was under investigation by AstraZeneca for the treatment of overactive bladder. As of March 2003, the drug was in phase II trials; however, as of October 2004, it no longer appeared on the companyâs development pipeline.
AZD0947
AZD0947 [drugbank:DB04848]

Erythromycin is a macrolide antibiotic produced by Streptomyces erythreus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits; binding inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins. Erythromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Erythromycin
Erythromycin [drugbank:DB00199]

Cefepime is a fourth-generation cephalosporin antibiotic developed in 1994. Cefepime has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. Cefepime is usually reserved to treat severe nosocomial pneumonia, infections caused by multi-resistant microorganisms (e.g. Pseudomonas aeruginosa) and empirical treatment of febrile neutropenia.
Cefepime
Cefepime [drugbank:DB01413]

ABT-089 is a neuronal nicotinic acetylcholine receptor agonist that may have therapeutic utility for the treatment of several neurological disorders including Alzheimer, Attention Deficit Hyperactivity Disorder and Schizophrenia/Schizoaffective disorders. In radioligand binding studies, ABT-089 has shown selectivity toward the alpha4beta2 nAChR subtype as compared to the alpha7 and alpha1beta1deltagamma nAChR subtypes. Neuronal nicotinic acetylcholine receptors (nAChRs) modulate the release of several important neurotransmitters, such as acetylcholine and dopamine.
ABT-089
ABT-089 [drugbank:DB05458]

Bosentan is a dual endothelin receptor antagonist important in the treatment of pulmonary artery hypertension (PAH). It is licensed in the United States, the European Union and other countries by Actelion Pharmaceuticals for the management of PAH under the trade name Tracleer®. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure.
Bosentan
Bosentan [drugbank:DB00559]

Propericiazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.
Propericiazine
Propericiazine [drugbank:DB01608]

Thymidine-3',5'-Diphosphate
Thymidine-3',5'-Diphosphate [drugbank:DB04205]

5-(6-D-Ribitylamino-2,4-Dihydroxypyrimidin-5-Yl)-1-Pentyl-Phosphonic Acid
5-(6-D-Ribitylamino-2,4-Dihydroxypyrimidin-5-Yl)-1-Pentyl-Phosphonic Acid [drugbank:DB04266]

A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent. [PubChem]
Carteolol
Carteolol [drugbank:DB00521]

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). [PubChem]
Procaine
Procaine [drugbank:DB00721]

(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE [drugbank:DB07860]

A non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons. [PubChem]
L-Proline
L-Proline [drugbank:DB00172]

A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)
Fluorescein
Fluorescein [drugbank:DB00693]

Vinblastine derivative with antineoplastic activity against cancer. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (antineoplastic combined chemotherapy protocols). [PubChem]
Vindesine
Vindesine [drugbank:DB00309]

Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.
Moxifloxacin
Moxifloxacin [drugbank:DB00218]

Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group, but while dutasteride inhibits both isoforms of 5-alpha reductase, finasteride inhibits only one. Even so, a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH. [Wikipedia]
Dutasteride
Dutasteride [drugbank:DB01126]

6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM
6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM [drugbank:DB08504]

6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE [drugbank:DB08645]

GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE [drugbank:DB04754]

9-(4-HYDROXY-2,6-DIMETHYL-PHENYL)-3,7-DIMETHYL-NONA-4,6,8-TRIENOIC ACID
9-(4-HYDROXY-2,6-DIMETHYL-PHENYL)-3,7-DIMETHYL-NONA-4,6,8-TRIENOIC ACID [drugbank:DB08455]

DECANE-1-THIOL
DECANE-1-THIOL [drugbank:DB07611]

Allo-Isoleucine
Allo-Isoleucine [drugbank:DB01739]

N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE
N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE [drugbank:DB06859]

Enalkiren
Enalkiren [drugbank:DB03395]

Sulfopyruvate
Sulfopyruvate [drugbank:DB02156]

PA-824 is a nitroimidazole, a class of novel anti-bacterial agents. As a potential TB therapy, it has many attractive characteristics - most notably its novel mechanism of action, its activity in vitro against all tested drug-resistant clinical isolates, and its activity as both a potent bactericidal and a sterilizing agent in mice. In addition, the compound shows no evidence of mutagenicity in a standard battery of genotoxicity studies, no significant cytochrome P450 interactions, and no significant activity against a broad range of Gram-positive and Gram-negative bacteria.
PA824
PA824 [drugbank:DB05154]

A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine. [PubChem]
Putrescine
Putrescine [drugbank:DB01917]

Cortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
Cortisone acetate
Cortisone acetate [drugbank:DB01380]

N-Cyclohexyl-N'-(4-Iodophenyl)Urea
N-Cyclohexyl-N'-(4-Iodophenyl)Urea [drugbank:DB02029]

(2s,3s)-Trans-2,3-Dihydro-3-Hydroxyanthranilic Acid
(2s,3s)-Trans-2,3-Dihydro-3-Hydroxyanthranilic Acid [drugbank:DB02124]

Fucitol
Fucitol [drugbank:DB03815]

Remikiren is an orally active, high specificity renin inhibitor.
Remikiren
Remikiren [drugbank:DB00212]

Glyoxalate, Glyoxylate
Glyoxalate, Glyoxylate [drugbank:DB04343]

Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature ejaculation in December 2004. In October 2005, the company received a FDA Non-Approvable letter from the FDA, at which time they planned to work with regulators to address outstanding questions.
Dapoxetine
Dapoxetine [drugbank:DB04884]

Acepromazine is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic.
Acepromazine
Acepromazine [drugbank:DB01614]

benzyl (2-oxopropyl)carbamate
benzyl (2-oxopropyl)carbamate [drugbank:DB07293]

A non-selective beta-adrenergic antagonist with a long half-life, used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension. Nadolol is also used for migraine disorders and for tremor. [PubChem]
Nadolol
Nadolol [drugbank:DB01203]

A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity. [PubChem]
N-Ethyl-5'-Carboxamido Adenosine
N-Ethyl-5'-Carboxamido Adenosine [drugbank:DB03719]

K-252a
K-252a [drugbank:DB02152]

N-(5,5,8,8-Tetramethyl-5,8-Dihydro-Naphthalen-2-Yl)-Terephthalamic Acid
N-(5,5,8,8-Tetramethyl-5,8-Dihydro-Naphthalen-2-Yl)-Terephthalamic Acid [drugbank:DB03873]

Calcipotriol (INN) or calcipotriene (USAN) is a sythetic derivative of calcitriol or Vitamin D.
Calcipotriol
Calcipotriol [drugbank:DB02300]

D-Para-Chlorophenyl-1-Acteamidoboronic Acid Alanine
D-Para-Chlorophenyl-1-Acteamidoboronic Acid Alanine [drugbank:DB02560]

Tris-Hydroxymethyl-Methyl-Ammonium
Tris-Hydroxymethyl-Methyl-Ammonium [drugbank:DB03570]

3-Benzylaminocarbonylphenyl-Alpha-D-Galactoside
3-Benzylaminocarbonylphenyl-Alpha-D-Galactoside [drugbank:DB03446]

N-Trimethyllysine
N-Trimethyllysine [drugbank:DB03977]

Allolactose
Allolactose [drugbank:DB04116]

NT-501 is Neurotech's lead product which is in two Phase II/III clinical trials for the treatment of visual loss associated with retinitis pigmentosa and a Phase II trial for the treatment of the dry form of age-related macular degeneration. Neurotech is also evaluating other factors that can be used with its proprietary delivery technology, Encapsulated Cell Technology (ECT), to treat additional retinal diseases.
NT-501
NT-501 [drugbank:DB05344]

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperglycemia (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.
Potassium Iodide
Potassium Iodide [drugbank:DB06715]

N-oxo-2-(phenylsulfonylamino)ethanamide
N-oxo-2-(phenylsulfonylamino)ethanamide [drugbank:DB07922]

A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
Amobarbital
Amobarbital [drugbank:DB01351]

4-METHYL-2H-CHROMEN-2-ONE
4-METHYL-2H-CHROMEN-2-ONE [drugbank:DB08785]

A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin. [PubChem]
L-Tyrosine
L-Tyrosine [drugbank:DB00135]

(4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester
(4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) ester [drugbank:DB03333]

MLN1202, a novel humanized monoclonal antibody, specifically targets CCR2 chemokine receptors found on the surface of certain white blood cells including macrophages and monocytes. Preclinical studies suggest that CCR2 plays an important role in the trafficking of monocytes and macrophages to sites of inflammation. The recruitment of macrophages to the arterial wall is believed to be a critical step in the development of atherosclerosis. MLN1202 fully met the primary endpoint in Phase II clinical study of patients at high risk for atherosclerosis
MLN-1202
MLN-1202 [drugbank:DB05486]

2-((3',5'-DIMETHOXY-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
2-((3',5'-DIMETHOXY-4'-HYDROXYPHENYL)AZO)BENZOIC ACID [drugbank:DB08196]

BF-37 for the treatment of atopic dermatitis and/or psoriasis. The active ingredient in BF-37 is Riluzole, applied in a topical formulation, which is believed to correct the imbalances of the immune system that cause atopic dermatitis or psoriasis.
BF-37
BF-37 [drugbank:DB05755]

(1-Tert-Butyl-5-Hydroxy-1h-Pyrazol-4-Yl)-(6-Methanesulfonyl-4'-Methoxy-2-Methyl-Biphenyl-3-Yl)-Methanone
(1-Tert-Butyl-5-Hydroxy-1h-Pyrazol-4-Yl)-(6-Methanesulfonyl-4'-Methoxy-2-Methyl-Biphenyl-3-Yl)-Methanone [drugbank:DB02850]

4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid
4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid [drugbank:DB08147]

4-Androstenediol
4-Androstenediol [drugbank:DB01526]

2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride
2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride [drugbank:DB01897]

(2R)-3-(phosphonooxy)propane-1,2-diyl diheptanoate
(2R)-3-(phosphonooxy)propane-1,2-diyl diheptanoate [drugbank:DB08376]

S-Methyl Phosphocysteine
S-Methyl Phosphocysteine [drugbank:DB02461]

One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent. [PubChem]
4-Butyrolactone
4-Butyrolactone [drugbank:DB04699]

(CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER
(CHLOROACETYL)CARBAMIC ACID (3R,4S,5S,5R)-5-METHOXY-4-[(2R,3R)-2-METHYL-3-(3-METHYL-2-BUTENYL)OXIRANYL]-1-OXASPIRO[2.5]OCT-6-YL ESTER [drugbank:DB08633]

3,4-Dihydroxybenzoic Acid
3,4-Dihydroxybenzoic Acid [drugbank:DB03946]

A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator. [PubChem]
Aminacrine
Aminacrine [drugbank:DB02842]

Uridine-5'-Diphosphate-N-Acetylmuramoyl-L-Alanine-D-Glutamate
Uridine-5'-Diphosphate-N-Acetylmuramoyl-L-Alanine-D-Glutamate [drugbank:DB02314]

Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. It is manufactured by TAP Pharmaceutical Products. Lansoprazole has been marketed for many years and is one of several PPI's available.
Lansoprazole
Lansoprazole [drugbank:DB00448]

Saprisartan is an AT1 receptor antagonist. It is based on medications of losartan's prototypical chemical structure. The mode of (functional) AT1 receptor antagonism has been characterized as insurmountable/noncompetitive for saprisartan. It is very likely that slow dissociation kinetics from the AT1 receptor underlie insurmountable antagonism.(10579749)
Saprisartan
Saprisartan [drugbank:DB01347]

Beta-L-Methyl-Fucose
Beta-L-Methyl-Fucose [drugbank:DB03194]

Cytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety. [PubChem]
Cytidine-5'-Triphosphate
Cytidine-5'-Triphosphate [drugbank:DB02431]

Palonosetron (INN, trade name Aloxi) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of its class approved for this use by the U.S. Food and Drug Administration. As of 2008, it is the most recent 5-HT3 antagonist to enter clinical use. [wikipedia]
Palonosetron
Palonosetron [drugbank:DB00377]

Citalopram hydrobromide belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Citalopram and its N-demethylated metabolites exist as a racemic mixture but its effects are largely due to the S-enantiomer, S-citalopram and S-demthylcitalopram. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Citalopram is approved for treatment of depression. Unlabeled indications include mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy. Citalopram has the fewest drug-drug interactions of the SSRIs.
Citalopram
Citalopram [drugbank:DB00215]

L-Histidine Beta Naphthylamide
L-Histidine Beta Naphthylamide [drugbank:DB01938]

2-NAPHTHALENESULFONIC ACID
2-NAPHTHALENESULFONIC ACID [drugbank:DB08254]

Diundecyl Phosphatidyl Choline
Diundecyl Phosphatidyl Choline [drugbank:DB02777]

C1-INH is human pasteurized C1-inhibitor concentrate to treat patients with hereditary angioedema (HAE), a rare genetic disorder that can lead to painful and sometimes life-threatening attacks of edema (swelling) of the face, airway, abdomen, and extremities.
C1-INH
C1-INH [drugbank:DB05341]

5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE [drugbank:DB06964]

QR-334 is under investigation for the treatment of sialorrhea. Sialorrhea is an excess secretion of saliva produced by the salivary glands, resulting in drooling. No pharmaceutical interventions currently exist to treat sialorrhea. The symptom is associated with many diseases including Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrigâs Disease, Cerebral Palsy, Parkinson's Disease, and Muscular Dystrophy.
QR-334
QR-334 [drugbank:DB05473]

(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE
(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE [drugbank:DB07064]

2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
2-NONYL-4-HYDROXYQUINOLINE N-OXIDE [drugbank:DB08453]

Benzo[B]Thiophene-2-Carboxamidine
Benzo[B]Thiophene-2-Carboxamidine [drugbank:DB04446]

3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE
3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE [drugbank:DB07256]

Allyl-{6-[3-(4-Bromo-Phenyl)-1-Methyl-1h-Indazol-6-Yl]Oxy}Hexyl)-N-Methylamine
Allyl-{6-[3-(4-Bromo-Phenyl)-1-Methyl-1h-Indazol-6-Yl]Oxy}Hexyl)-N-Methylamine [drugbank:DB03888]

PS386113 is a small molecule drug candidate under investigation for the treatment of inflammatory disorders. It is being developed by Schering-Plough and Pharmacopeia. Little information has been released about PS386113.
PS386113 [drugbank:DB05211]

(3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine
(3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine [drugbank:DB07001]

4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE
4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE [drugbank:DB07029]

1,3,5-Trichloro-Benzene
1,3,5-Trichloro-Benzene [drugbank:DB03836]

(5z)-2-[(1s,2r)-1-Amino-2-Hydroxypropyl]-5-[(4-Amino-1h-Indol-3-Yl)Methylene]-3-(2-Hydroxyethyl)-3,5-Dihydro-4h-Imidazol-4-One
(5z)-2-[(1s,2r)-1-Amino-2-Hydroxypropyl]-5-[(4-Amino-1h-Indol-3-Yl)Methylene]-3-(2-Hydroxyethyl)-3,5-Dihydro-4h-Imidazol-4-One [drugbank:DB01641]

N~2~-Succinylornithine
N~2~-Succinylornithine [drugbank:DB03582]

Peldesine
Peldesine [drugbank:DB02568]

Hypophosphite
Hypophosphite [drugbank:DB04053]

TRX1 is a humanized antibody that binds to the CD4 receptor found on a subset of T cells. TRX1 is being developed for the potential treatment of autoimmune diseases in collaboration with Genentech, Inc. TolerRx is currently conducting a Phase I clinical study of TRX1 in the United Kingdom.
TRX1
TRX1 [drugbank:DB05863]

3-chloro-5-[2-chloro-5-(1H-pyrazolo[3,4-b]pyridin-3-ylmethoxy)phenoxy]benzonitrile
3-chloro-5-[2-chloro-5-(1H-pyrazolo[3,4-b]pyridin-3-ylmethoxy)phenoxy]benzonitrile [drugbank:DB08459]

1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE [drugbank:DB08035]

5,4'-Dideoxyflavanone
5,4'-Dideoxyflavanone [drugbank:DB04274]

2-T-BUTYLAMINO-4-ETHYLAMINO-6-METHYLTHIO-S-TRIAZINE
2-T-BUTYLAMINO-4-ETHYLAMINO-6-METHYLTHIO-S-TRIAZINE [drugbank:DB08215]

2'-Chloro-Biphenyl-2,3-Diol
2'-Chloro-Biphenyl-2,3-Diol [drugbank:DB01925]

CRA_10950 [drugbank:DB03494]

methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate
methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate [drugbank:DB07147]

Ethyl Oxo(Piperidin-1-Yl)Acetate
Ethyl Oxo(Piperidin-1-Yl)Acetate [drugbank:DB02419]

Alpha-Aminoisobutyric Acid
Alpha-Aminoisobutyric Acid [drugbank:DB02952]

2-Amino-Adenosine
2-Amino-Adenosine [drugbank:DB04102]

Benzylamine
Benzylamine [drugbank:DB02464]

6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE [drugbank:DB07218]

(5r)-5-Amino-6-Hydroxyhexylcarbamic Acid
(5r)-5-Amino-6-Hydroxyhexylcarbamic Acid [drugbank:DB02437]

1-Methylcytosine
1-Methylcytosine [drugbank:DB04314]

A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Prilocaine
Prilocaine [drugbank:DB00750]

N-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-3,5-dimethylbenzamide
N-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-3,5-dimethylbenzamide [drugbank:DB07695]

Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. It is used to cure infection of upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis etc.
Bacampicillin
Bacampicillin [drugbank:DB01602]

Clindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Clindamycin
Clindamycin [drugbank:DB01190]

2,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitol
2,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitol [drugbank:DB04790]

Malate Like Intermediate
Malate Like Intermediate [drugbank:DB03343]

Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011.
Deferiprone
Deferiprone [drugbank:DB08826]

A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. [PubChem]
Lidocaine
Lidocaine [drugbank:DB00281]

Ribulose-5-Phosphate
Ribulose-5-Phosphate [drugbank:DB04034]

4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID [drugbank:DB08251]

THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)
THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE) [drugbank:DB07363]

2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine
2,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]Pyrimidine [drugbank:DB02919]

4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE [drugbank:DB07538]

(2S)-1-methyl-2-[(2S,4R)-2-methyl-4-phenylpentyl]piperidine
(2S)-1-methyl-2-[(2S,4R)-2-methyl-4-phenylpentyl]piperidine [drugbank:DB08071]

Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
Fosinopril
Fosinopril [drugbank:DB00492]

Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. [PubChem]
D-Myo-Inositol-1,4,5-Triphosphate
D-Myo-Inositol-1,4,5-Triphosphate [drugbank:DB03401]

PTC299 is a novel, orally administered small-molecule designed to inhibit the production of vascular endothelial growth factor (VEGF) in tumors. Overexpression of VEGF plays a key role in multiple diseases including cancer and macular degeneration. PTC299 was discovered through PTC's GEMS technology by targeting the post-transcriptional processes that regulate VEGF formation, and is currently being developed for the treatment of cancer.
PTC299
PTC299 [drugbank:DB05173]

N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE
N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE [drugbank:DB06939]

Arsthinol (INN) is an antiprotozoal agent. It was synthesized for the first time in 1949 by Ernst A.H. Friedheim by complexation of acetarsol with 2,3-dimercaptopropanol (British anti-Lewisite) and has been demonstrated to be effective against amoebiasis and yaws. It was marketed few years latter by Endo Products (Balarsen, Tablets, 0.1 g). Among trivalent organoarsenicals, arthinol was considered as very well tolerated. Recently, it was studied for its anticancer activity. [Wikipedia]
Arsthinol
Arsthinol [drugbank:DB08928]

A tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections. [PubChem]
Minocycline
Minocycline [drugbank:DB01017]

Adenylosuccinic Acid
Adenylosuccinic Acid [drugbank:DB04418]

N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE [drugbank:DB07284]

2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol [drugbank:DB04141]

An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
5-N-Acetyl-Alpha-D-Neuraminic Acid
5-N-Acetyl-Alpha-D-Neuraminic Acid [drugbank:DB01894]

6-Fluoro-2-(2'-Fluoro-1,1'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid
6-Fluoro-2-(2'-Fluoro-1,1'-Biphenyl-4-Yl)-3-Methylquinoline-4-Carboxylic Acid [drugbank:DB03523]

TERT-BUTYL [(1S)-2-METHYL-1-(1,3,4-OXADIAZOL-2-YL)PROPYL]CARBAMATE
TERT-BUTYL [(1S)-2-METHYL-1-(1,3,4-OXADIAZOL-2-YL)PROPYL]CARBAMATE [drugbank:DB08337]

(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE [drugbank:DB08674]

Merck has developed a selective PDE4 inhibitor for the treatment of inflammatory diseases, such as asthma and chronic obstructive pulmonary disease. Whereas the potential therapeutic utility of PDE4 inhibition has been demonstrated in various preclinical animal models (e.g., in rheumatoid arthritis and multiple sclerosis), clinical evaluation has been restricted by dose-limiting side effects, mainly nausea and emesis.
PDE4
PDE4 [drugbank:DB05876]

Betahistine is an antivertigo drug first used for treating vertigo assosicated with MÃ©niÃ¨re's disease. It is also commonly used for patients with balance disorders.
Betahistine
Betahistine [drugbank:DB06698]

AC-100 is a novel synthetic peptide derived from an endogenous human protein produced by bone and dental cells (a fragment from matrix extracellular phosphoglycoprotein). It is being developed by Acologix, Inc.
AC-100
AC-100 [drugbank:DB05671]

(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide
(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-Benzamide [drugbank:DB02479]

Zolpidem is a prescription short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to benzodiazepine receptors which are located on the gamma-aminobutyric acid receptors. Zolpidem is used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). It is classified as an imidazopyridine. As an anticonvulsant and muscle relaxant, the beneficial effects start to emerge at 10 and 20 times the dose required for sedation, respectively. For that reason, it has never been approved for either muscle relaxation or seizure prevention. Recently, zolpidem has been cited in various medical reports mainly in the United Kingdom as waking persistent vegetative state (PVS) patients, and dramatically improving the conditions of people with brain injuries. [Wikipedia]
Zolpidem
Zolpidem [drugbank:DB00425]

An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
Spectinomycin
Spectinomycin [drugbank:DB00919]

2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE
2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE [drugbank:DB07918]

(R)-2-Hydroxy-3-Sulfopropanoic Acid
(R)-2-Hydroxy-3-Sulfopropanoic Acid [drugbank:DB02334]

(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione
(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione [drugbank:DB02303]

4-(3-ethylthiophen-2-yl)benzene-1,2-diol
4-(3-ethylthiophen-2-yl)benzene-1,2-diol [drugbank:DB08718]

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinsonâs Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome. It was later found that pergolide increased the risk of cardiac valvulopathy. The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007.
Pergolide
Pergolide [drugbank:DB01186]

3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE
3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE [drugbank:DB08124]

Pmp-Hydroxyisoxazole, Pyridoxamine-5-Phosphate-Hydroxyisoxazole
Pmp-Hydroxyisoxazole, Pyridoxamine-5-Phosphate-Hydroxyisoxazole [drugbank:DB03097]

A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. [PubChem]
Sulfisoxazole
Sulfisoxazole [drugbank:DB00263]

Purified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation.
Botulinum Toxin Type A
Botulinum Toxin Type A [drugbank:DB00083]

GFT14 is a new class of medicaction for treatment of cardiometabolic disease. GFT14 aims to target mixed dyslipidemia of type IIb (high levels of triglycerides and LDL-C) as one of the major indications of cardiometabolic disease. GFT14 is destined to improve the condition of patients at risk from cardiovascular disease by a simultaneous and favorable action on the plasmatic lipids (rise of HDL- cholesterol et lowering of triglycerides) and on other risk factors such as hypertension or diabetes. Orally absorbed GFT14 has absolutely no structural link with current treatments for dyslipidemia (statin or fibrate based). The risks of medical interaction are weak and GFT14 may be easily combined with statins or other antidiabetic molecules (glitazones).
GFT14
GFT14 [drugbank:DB05061]

(2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE
(2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE [drugbank:DB08239]

SU4984
SU4984 [drugbank:DB02058]

ACP-103 is a potent and selective 5-HT2A inverse agonist, as a co-therapy for schizophrenia. ACP-103 is a novel therapy for schizophrenia to be used in combination with currently available antipsychotic drugs including haloperidol, Zyprexa, Risperdal and Seroquel.
ACP-103
ACP-103 [drugbank:DB05316]

[(4S)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE
[(4S)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE [drugbank:DB08548]

Mequitazine is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Mequitazine
Mequitazine [drugbank:DB01071]

2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE
2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE [drugbank:DB07453]

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Touretteâs disorder). Unlabeled indications include panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy, autistic disorder, trichotillomania, onchophagia, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine is rapidly absorbed from the gastrointestinal tract and demethylated in the liver to its primary active metabolite, desmethylclomipramine.
Clomipramine
Clomipramine [drugbank:DB01242]

A sulfated pentosyl polysaccharide with heparin-like properties. [PubChem]
Pentosan Polysulfate
Pentosan Polysulfate [drugbank:DB00686]

An opioid analgesic chemically related to and with an action resembling that of meperidine, but more rapid in onset and of shorter duration. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1067)
Betaprodine
Betaprodine [drugbank:DB01473]

MT-Immucillin-H
MT-Immucillin-H [drugbank:DB03881]

A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. [PubChem]
Palmitic Acid
Palmitic Acid [drugbank:DB03796]

A first generation nonsteroidal selective estrogen receptor modulator (SERM) that is structurally related to tamoxifen. Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. [PubChem]
Toremifene
Toremifene [drugbank:DB00539]

L-Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate
L-Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate [drugbank:DB03787]

GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE
GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE [drugbank:DB04757]

2,4-Dihydroxy-3,3-Dimethyl-Butyrate
2,4-Dihydroxy-3,3-Dimethyl-Butyrate [drugbank:DB01930]

1-Aminocyclopropylphosphonate
1-Aminocyclopropylphosphonate [drugbank:DB03053]

Cerepro is a novel gene-based product for the treatment of patients with operable high grade glioma, a type of malignant brain tumour, given in addition to standard surgery and radiotherapy/chemotherapy. It is being developed by Ark Therapeutics.
EG009
EG009 [drugbank:DB04907]

Sulfathiazole is a short-acting sulfa drug. It used to be a common oral and topical antimicrobial until less toxic alternatives were discovered. It is still occasionally used, sometimes in combination with sulfabenzamide and sulfacetamide.
Sulfathiazole
Sulfathiazole [drugbank:DB06147]

7-Deaza-7-Cyano-Guanine
7-Deaza-7-Cyano-Guanine [drugbank:DB03074]

3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide
3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide [drugbank:DB07190]

An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem]
Guaifenesin
Guaifenesin [drugbank:DB00874]

(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL [drugbank:DB07638]

Phosphoric Acid Mono-[3-Amino-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester
Phosphoric Acid Mono-[3-Amino-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester [drugbank:DB03233]

5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE
5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE [drugbank:DB07117]

Desmoteplase is a chemical in the saliva of vampire bats. It activates plasminogen to the serine protease, plasmin. Plasmin acts by breaking down fibrin blood clots. When a vampire bat bites its victim, it secretes an enzyme that prevents the blood from clotting. The enzyme is called DSPA (Desmodus rotundus salivary plasminogen activator) and scientists are using DSPA as stroke and heart attack medication. Desmoteplase is a recombinant form of vampire bat DSPA (Salivary plasminogen activator alpha 1).
Desmoteplase
Desmoteplase [drugbank:DB04925]

Glucosamine 4-Phosphate
Glucosamine 4-Phosphate [drugbank:DB02865]

Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5Â´-phosphodinucleotide and 5Â´-phosphooligonucleotide end products without affecting intracellular DNA. In individuals with cystic fibrosis, extracellular DNA, which is an extremely viscous anion, is released by degenerating leukocytes that accumulate during inflammatory responses to infections. Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity.
Dornase alfa
Dornase alfa [drugbank:DB00003]

N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide [drugbank:DB07020]

Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
Paricalcitol
Paricalcitol [drugbank:DB00910]

N-(pyridin-3-ylmethyl)aniline
N-(pyridin-3-ylmethyl)aniline [drugbank:DB06851]

A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. [PubChem]
Metolazone
Metolazone [drugbank:DB00524]

2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol
2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol [drugbank:DB02676]

A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. [PubChem]
Prednisone
Prednisone [drugbank:DB00635]

L-BENZYLSUCCINIC ACID
L-BENZYLSUCCINIC ACID [drugbank:DB07506]

8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide
8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [drugbank:DB04059]

(S)-Hmg-Coa
(S)-Hmg-Coa [drugbank:DB03169]

AS1409 is a genetically engineered fusion protein made up of two distinct components. One is the cytokine IL12, which has anti-cancer activity. The other is an antibody that targets tumours. It is developed by Antisoma is in a phase I of clinical trial for the treatment of renal cancer and melanoma.
AS1409
AS1409 [drugbank:DB05182]

Pyrrole-2-Carboxylate
Pyrrole-2-Carboxylate [drugbank:DB02543]

YKP10A is a novel, new antidepressant that may affect dopamine neurotransmission. It provides antidepressant activity in patients with major depression.
YKP-10A
YKP-10A [drugbank:DB05795]

4,4'[1,6-Hexanediylbis(Oxy)]Bisbenzenecarboximidamide
4,4'[1,6-Hexanediylbis(Oxy)]Bisbenzenecarboximidamide [drugbank:DB03808]

Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem]
Simvastatin
Simvastatin [drugbank:DB00641]

Phenylphosphate
Phenylphosphate [drugbank:DB03298]

XL518 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity being developed by Exelixis.
XL518
XL518 [drugbank:DB05239]

(3Z,5S,6R,7S,8S,8aR)-3-(octylimino)hexahydro[1,3]oxazolo[3,4-a]pyridine-5,6,7,8-tetrol
(3Z,5S,6R,7S,8S,8aR)-3-(octylimino)hexahydro[1,3]oxazolo[3,4-a]pyridine-5,6,7,8-tetrol [drugbank:DB07367]

Diguanosine-5'-Triphosphate
Diguanosine-5'-Triphosphate [drugbank:DB03931]