6-Oxo-8,9,10,11-Tetrahydro-7h-Cyclohepta[C][1]Benzopyran-3-O-Sulfamate
6-Oxo-8,9,10,11-Tetrahydro-7h-Cyclohepta[C][1]Benzopyran-3-O-Sulfamate [drugbank:DB02292]

3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE
3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE [drugbank:DB08093]

R411 is a non-steroid oral medicine for the treatment of asthma. It is not immunosuppressive, but blocks the activation and recruitment of cells involved in respiratory inflammation. It is a dual-acting competitive integrin antagonist (as compared to previously developed single integrin antagonists or SIAs) that prevents binding of V-CAM1 to either a4b1 or a4b7.
R411 [drugbank:DB05468]

1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea [drugbank:DB06882]

1-(3-chloro-4-methylphenyl)-3-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}urea
1-(3-chloro-4-methylphenyl)-3-{2-[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}urea [drugbank:DB08027]

Humanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). Synagis is a composite of human (95%) and murine (5%) antibody sequences. The human heavy chain sequence was derived from the constant domains of human IgG1 and the variable framework regions of the VH genes Cor (1) and Cess (2). The human lightchain sequence was derived from the constant domain of Ck and the variable framework regions of the VL gene K104 withJk-4. Palivizumab is expressed from a stable murine (mouse) myeloma cell line (NS0). Palivizumab is composed of to heavy chains (50.6 kDa each) and two light chains (27.6 kDa each), contains 1-2% carbohydrate by weight and has a molecular weight of 147.7 kDa +/- 1 kDa (MALDI-TOF)
Palivizumab
Palivizumab [drugbank:DB00110]

Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone]
Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] [drugbank:DB04392]

A narcotic analgesic proposed for moderate to severe pain. It may be habituating. [PubChem] Tramadol is also prepared as a variable release capsules, marketed under the brand name ConZip. For example, a 150 mg capsule will contain 37.5 mg of the immediate release form and 112.5 mg of the extended release form.
Tramadol
Tramadol [drugbank:DB00193]

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to Î² cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response to meals decreasing postprandial blood glucose levels. It should only be taken with meals and meal-time doses should be skipped with any skipped meal. Approximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. The average weight gain caused by meglitinides appears to be lower than that caused by sulfonylureas and insulin and appears to occur only in those naÃ¯ve to oral antidiabetic agents. Due to their mechanism of action, meglitinides may cause hypoglycemia although the risk is thought to be lower than that of sulfonylureas since their action is dependent on the presence of glucose. In addition to reducing postprandial and fasting blood glucose, meglitnides have been shown to decrease glycosylated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Meglitinides appear to be more effective at lowering postprandial blood glucose than metformin, sulfonylureas and thiazolidinediones. Repaglinide is extensively metabolized in the liver and excreted in bile. Repaglinide metabolites do not possess appreciable hypoglycemic activity. Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine.
Repaglinide
Repaglinide [drugbank:DB00912]

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]
Hydroxyzine
Hydroxyzine [drugbank:DB00557]

(2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE
(2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE [drugbank:DB07246]

GERANYLGERANYL DIPHOSPHATE
GERANYLGERANYL DIPHOSPHATE [drugbank:DB07841]

2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid
2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid [drugbank:DB03991]

1,N6-Ethenoadenine
1,N6-Ethenoadenine [drugbank:DB01952]

A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography. [PubChem]
Diatrizoate
Diatrizoate [drugbank:DB00271]

2-{1-[2-Amino-2-(4-Hydroxy-Phenyl)-Acetylamino]-2-Oxo-Ethyl}-5,5-Dimethyl-Thiazolidine-4-Carboxylic Acid
2-{1-[2-Amino-2-(4-Hydroxy-Phenyl)-Acetylamino]-2-Oxo-Ethyl}-5,5-Dimethyl-Thiazolidine-4-Carboxylic Acid [drugbank:DB03658]

NS2359 is a triple monoamine re-uptake inhibitor with a new, unique drug profile expected to yield important benefits compared to existing treatments of depression. Enhancing the function of the three neurotransmitters serotonin, noradrenalin and dopamine, NS2359 has a desired "triple-mode-of-action". This mode of action is expected to produce an optimal reduction in all disease symptoms and the possibility of an earlier onset of action compared to antidepressants already on the market.
NS-2359 [drugbank:DB05805]

(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one
(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one [drugbank:DB07017]

ART-123 is a novel, recombinant and soluble thrombomodulin (ART-123). It is a human protein with both thrombin inhibiting and protein C stimulating activities, for the potential treatment of thromboembolism and blood clotting disorders, such as disseminated intravascular thromboembolism. (PMID: 12211414)
ART-123
ART-123 [drugbank:DB05777]

Molecualar iodine has been developed by Symbollon Pharmaceuticals. It is a potential treatment for moderate to severe cyclic pain and tenderness (clinical mastalgia) associated with fibrocystic breast disease (FBD).
molecular iodine
molecular iodine [drugbank:DB05382]

4-(Acetylamino)-3-[(Hydroxyacetyl)Amino]Benzoic Acid
4-(Acetylamino)-3-[(Hydroxyacetyl)Amino]Benzoic Acid [drugbank:DB04565]

(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE [drugbank:DB08676]

Ethylisothiourea
Ethylisothiourea [drugbank:DB02234]

(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine [drugbank:DB07015]

(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid [drugbank:DB08298]

INHIBITOR Q8467 OF DUPONT MERCK
INHIBITOR Q8467 OF DUPONT MERCK [drugbank:DB04609]

4-Thio-D-Glucose
4-Thio-D-Glucose [drugbank:DB03599]

PLX4032, a targeted anticancer agent, selectively inhibits the cancer-causing BRAF(V600E) gene found in subsets of different cancers, including 70% of malignant melanomas and a significant number of colorectal and thyroid tumors. Plexxikon, the company developing PLX4032, will use a new test to detect the presence of this cancer-causing gene to identify patients most likely to respond to PLX4032, enabling a personalized form of treatment.
PLX4032
PLX4032 [drugbank:DB05238]

Zuclopenthixol decanoate is an antipsychotic thioxanthene drug indicated for the longer term maintenance therapy of schizophrenic episodes.
Zuclopenthixol decanoate
Zuclopenthixol decanoate [drugbank:DB08920]

Absence of molybdenum cofactor leads to accumulation of toxic levels of sulphite and neurological damage usually leading to death within months of birth, due to the lack of active sulfite oxidase.
Molybdenum Cofactor
Molybdenum Cofactor [drugbank:DB02137]

Pexelizumab is a humanized monoclonal antibody used as an immunosuppressive drug. It is being investigated by Alexion Pharmaceuticals.
Pexelizumab
Pexelizumab [drugbank:DB04949]

(3r,5r)-7-((1r,2r,6s,8r,8as)-2,6-Dimethyl-8-{[(2r)-2-Methylbutanoyl]Oxy}-1,2,6,7,8,8a-Hexahydronaphthalen-1-Yl)-3,5-Dihydroxyheptanoic Acid
(3r,5r)-7-((1r,2r,6s,8r,8as)-2,6-Dimethyl-8-{[(2r)-2-Methylbutanoyl]Oxy}-1,2,6,7,8,8a-Hexahydronaphthalen-1-Yl)-3,5-Dihydroxyheptanoic Acid [drugbank:DB03785]

4-iodo-acetamido phenylboronic acid
4-iodo-acetamido phenylboronic acid [drugbank:DB02122]

2-Phospho-D-Glyceric Acid
2-Phospho-D-Glyceric Acid [drugbank:DB03465]

A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with asthma, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. [PubChem]
Nedocromil
Nedocromil [drugbank:DB00716]

1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One
1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One [drugbank:DB01948]

Tecadenoson is a novel selective A1 adenosine receptor agonist that is currently being evaluated for the conversion of paroxysmal supraventricular tachycardia (PSVT) to sinus rhythm. It is being developed by CV Therapeutics, Inc.
Tecadenoson
Tecadenoson [drugbank:DB04954]

4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINE
4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINE [drugbank:DB07508]

Hexane
Hexane [drugbank:DB02764]

Piclamilast (RP-73,401), is a selective PDE4 inhibitor. It is comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as chronic obstructive pulmonary disease, bronchopulmonary dysplasia and asthma. It is a second generation compound that exhibits structural functionalities of the PDE4 inhibitors cilomilast and roflumilast. The structure for piclamilast was first elucidated in a 1995 European patent application.
Piclamilast
Piclamilast [drugbank:DB01791]

A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. [PubChem]
Nitroglycerin
Nitroglycerin [drugbank:DB00727]

Domoic Acid
Domoic Acid [drugbank:DB02852]

N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid
N-({(1R)-1-carboxy-2-[(4-fluorobenzyl)sulfanyl]ethyl}carbamoyl)-L-glutamic acid [drugbank:DB07754]

8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine
8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine [drugbank:DB04273]

Cellotriose
Cellotriose [drugbank:DB01697]

A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem]
Dihydroergotamine
Dihydroergotamine [drugbank:DB00320]

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast.
Calcium
Calcium [drugbank:DB01373]

A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide. [PubChem]
Tolazamide
Tolazamide [drugbank:DB00839]

2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM
2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM [drugbank:DB08575]

2-Bromo-6-Hydroxy-Purine
2-Bromo-6-Hydroxy-Purine [drugbank:DB04283]

Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Pirfenidone
Pirfenidone [drugbank:DB04951]

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Bleomycin
Bleomycin [drugbank:DB00290]

N-Carbamyl-D-Valine
N-Carbamyl-D-Valine [drugbank:DB01847]

8-Iodo-Guanine
8-Iodo-Guanine [drugbank:DB02985]

3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN
3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN [drugbank:DB07700]

3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid
3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acid [drugbank:DB07240]

Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA published a notice of its determination that Merital capsules were removed from the market for safety reasons (see the Federal Register of June 17, 1986 (51 FR 21981)). Approval of the NDA for Merital capsules was withdrawn on March 20, 1992 (see the Federal Register of March 20, 1992 (57 FR 9729)). Also withdrawn from the Canadian and UK markets.
Nomifensine
Nomifensine [drugbank:DB04821]

Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
Pipotiazine
Pipotiazine [drugbank:DB01621]

A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
Denileukin diftitox
Denileukin diftitox [drugbank:DB00004]

Etozoline (Diulozin, Elkapin, Etopinil) is a loop diuretic used in Europe.
Etozoline
Etozoline [drugbank:DB08982]

An essential amino acid that is physiologically active in the L-form. [PubChem]
L-Arginine
L-Arginine [drugbank:DB00125]

A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a tool in CNS studies and misused as a psychedelic.
Bufotenine
Bufotenine [drugbank:DB01445]

NAPHTHALEN-2-YL-3-ALANINE
NAPHTHALEN-2-YL-3-ALANINE [drugbank:DB07365]

undecan-2-one
undecan-2-one [drugbank:DB08688]

(2s,3s,8s,9s)-3-Amino-9-Methoxy-2,6,8-Trimethyl-10-Phenyldeca-4,6-Dienoic Acid
(2s,3s,8s,9s)-3-Amino-9-Methoxy-2,6,8-Trimethyl-10-Phenyldeca-4,6-Dienoic Acid [drugbank:DB01850]

2,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamide
2,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamide [drugbank:DB07694]

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
Tetracycline
Tetracycline [drugbank:DB00759]

2-Fluoroadenosine
2-Fluoroadenosine [drugbank:DB04441]

1'-Deazo-Thiamin Diphosphate
1'-Deazo-Thiamin Diphosphate [drugbank:DB01658]

Amonafide is a substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.
Amonafide
Amonafide [drugbank:DB05022]

An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. [PubChem]
Quinidine
Quinidine [drugbank:DB00908]

1,2-Dimethoxyethane
1,2-Dimethoxyethane [drugbank:DB01749]

(1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID
(1R)-2-PHENYLACETAMIDO-2-(3-CARBOXYPHENYL)ETHYL BORONIC ACID [drugbank:DB07466]

2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM [drugbank:DB07354]

An oral hypoglycemic agent which is rapidly absorbed and completely metabolized. [PubChem]
Glipizide
Glipizide [drugbank:DB01067]

An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
O-Sialic Acid (Chair Conformation)
O-Sialic Acid (Chair Conformation) [drugbank:DB02344]

N-(2-Ferrocenylethyl)Maleimide
N-(2-Ferrocenylethyl)Maleimide [drugbank:DB01703]

[1-(3-Hydroxy-2-Oxo-1-Phenethyl-Propylcarbamoyl)2-Phenyl-Ethyl]-Carbamic Acid Pyridin-4-Ylmethyl Ester
[1-(3-Hydroxy-2-Oxo-1-Phenethyl-Propylcarbamoyl)2-Phenyl-Ethyl]-Carbamic Acid Pyridin-4-Ylmethyl Ester [drugbank:DB02128]

(R)-N-[2-[1-(Aminoiminomethyl)-3-Piperidinyl]-1-Oxoethyl]-4-(Phenylethynyl)-L-Phenylalanine Methylester
(R)-N-[2-[1-(Aminoiminomethyl)-3-Piperidinyl]-1-Oxoethyl]-4-(Phenylethynyl)-L-Phenylalanine Methylester [drugbank:DB03453]

4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID [drugbank:DB08562]

2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE
2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE [drugbank:DB06953]

6,4'-Dihydroxy-3-Methyl-3',5'-Dibromoflavone
6,4'-Dihydroxy-3-Methyl-3',5'-Dibromoflavone [drugbank:DB01838]

1-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic Acid
1-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic Acid [drugbank:DB03417]

SUCCINIC ACID MONO-(13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL) ESTER
SUCCINIC ACID MONO-(13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL) ESTER [drugbank:DB08308]

2,4-Dihydroxy-7-(Methyloxy)-2h-1,4-Benzoxazin-3(4h)-One
2,4-Dihydroxy-7-(Methyloxy)-2h-1,4-Benzoxazin-3(4h)-One [drugbank:DB02185]

(R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
(R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE [drugbank:DB07454]

Ziprasidone (marketed as Geodon, Zeldox) was the fifth atypical antipsychotic to gain FDA approval (February 2001). Ziprasidone is Food and Drug Administration (FDA) approved for the treatment of schizophrenia, and the intramuscular injection form of ziprasidone is approved for acute agitation in schizophrenic patients. Ziprasidone has also received approval for acute treatment of mania associated with bipolar disorder. [Wikipedia]
Ziprasidone
Ziprasidone [drugbank:DB00246]

(2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide
(2r)-N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-3-[(4-Fluorophenyl)Sulfonyl]-2-Hydroxy-2-Methylpropanamide [drugbank:DB02932]

2,4-Dinitrophenyl 2-Deoxy-2-Fluoro-Beta-D-Allopyranoside
2,4-Dinitrophenyl 2-Deoxy-2-Fluoro-Beta-D-Allopyranoside [drugbank:DB02658]

NADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). It forms NADP with the addition of a phosphate group to the 2' position of the adenosyl nucleotide through an ester linkage. (Dorland, 27th ed)
NADH
NADH [drugbank:DB00157]

4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose
4-O-(4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Beta-D-Lyxo-Hexopyranosyl)-Alpha-D-Erythro-Hexopyranose [drugbank:DB02889]

octyl beta-D-galactopyranoside
octyl beta-D-galactopyranoside [drugbank:DB07924]

3-Hydroxybutyryl-Coenzyme A
3-Hydroxybutyryl-Coenzyme A [drugbank:DB03612]

(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE [drugbank:DB07788]

N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDE
N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDE [drugbank:DB07383]

19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one
19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one [drugbank:DB08338]

One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. [PubChem]
Sulfadiazine
Sulfadiazine [drugbank:DB00359]

3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid [drugbank:DB03176]

3'-THIO-THYMIDINE-5'-PHOSPHATE
3'-THIO-THYMIDINE-5'-PHOSPHATE [drugbank:DB08651]

Temsirolimus is an intravenous drug for the treatment of renal cell carcinoma (RCC), developed by Wyeth Pharmaceuticals and approved by the FDA in late May 2007, and was also approved by the European Medicines Agency (EMEA) on November 2007. It is a derivative of sirolimus and is sold as Torisel.
Temsirolimus
Temsirolimus [drugbank:DB06287]

Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form.
Coagulation factor VIIa
Coagulation factor VIIa [drugbank:DB00036]

3-Aminosuccinimide
3-Aminosuccinimide [drugbank:DB03487]

6-AMINO-4-(2-PHENYLETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE
6-AMINO-4-(2-PHENYLETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE [drugbank:DB08267]

4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine
4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine [drugbank:DB08194]

An inhibitor of DOPA decarboxylase, preventing conversion of levodopa to dopamine. It is used in parkinson disease to reduce peripheral adverse effects of levodopa. It has no antiparkinson actions by itself. [PubChem]
Carbidopa
Carbidopa [drugbank:DB00190]

3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE
3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE [drugbank:DB07959]

ICA-105665 is a novel small molecule compound for the treatment of epilepsy. It is a novel opener of the KCNQ ion channel which in preclinical studies has demonstrated a broad spectrum of activity in models of epilepsy. In addition, ICA-105665 has also demonstrated activity in certain models of neuropathic pain.
ICA-105665 [drugbank:DB06089]

2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid [drugbank:DB07615]

Semisynthetic, broad-spectrum antibacterial derived from cephaloridine and used especially for Pseudomonas and other gram-negative infections in debilitated patients. [PubChem]
Ceftazidime
Ceftazidime [drugbank:DB00438]

An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems. [PubChem]
Sparsomycin
Sparsomycin [drugbank:DB04222]

2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400
2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 [drugbank:DB03556]

2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE [drugbank:DB07286]

2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL
2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL [drugbank:DB07009]

2-{2-[2-2-(Methoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethanol
2-{2-[2-2-(Methoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethanol [drugbank:DB04332]

Etilefrine is an adrenergic agonist that appears to interact with beta-2 and some alpha adrenergic receptors. It has been used as a vasoconstrictor agent.
Etilefrine
Etilefrine [drugbank:DB08985]

Pivalate ester analog of ampicillin.
Pivampicillin
Pivampicillin [drugbank:DB01604]

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Phenylbutazone
Phenylbutazone [drugbank:DB00812]

5-(2,5-DICHLOROPHENYL)-2-FUROIC ACID
5-(2,5-DICHLOROPHENYL)-2-FUROIC ACID [drugbank:DB07758]

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as GermaninÂ®.
Suramin
Suramin [drugbank:DB04786]

FR239087 [drugbank:DB03370]

Proline Betaine
Proline Betaine [drugbank:DB04284]

(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide [drugbank:DB07423]

Daidzin
Daidzin [drugbank:DB02115]

BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE [drugbank:DB07580]

N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE [drugbank:DB07303]

MP470 is an oral, selective multi-targeted tyrosine kinase inhibitor that suppresses c-MET, c-RET and the mutant forms of c-KIT, PDGFR and FLT3. MP470 also suppresses Rad51 protein, a critical component of double-stranded DNA repair in cancer cells. Preclinical testing of MP470 has identified anti-tumor activity against a wide spectrum of cancers.
MP470
MP470 [drugbank:DB05216]

2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid
2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid [drugbank:DB07691]

N-(8,9,10-Trihydroxy-7-Hydroxymethyl-2,4-Dioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Dec-3-Yl-Acetamide
N-(8,9,10-Trihydroxy-7-Hydroxymethyl-2,4-Dioxo-6-Oxa-1,3-Diaza-Spiro[4.5]Dec-3-Yl-Acetamide [drugbank:DB03835]

Trifluorofurnesyl Diphosphate
Trifluorofurnesyl Diphosphate [drugbank:DB02808]

(2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID
(2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID [drugbank:DB04590]

5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE
5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE [drugbank:DB07158]

Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
Estrone
Estrone [drugbank:DB00655]

1-Methoxy-2-(2-Methoxyethoxy)Ethane
1-Methoxy-2-(2-Methoxyethoxy)Ethane [drugbank:DB02935]

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
Benzyl Benzoate
Benzyl Benzoate [drugbank:DB00676]

Fluorotryptophane can be used as substrate analogue to study enzyme mechanisms by NMR spectroscopy.
Fluorotryptophane
Fluorotryptophane [drugbank:DB03314]

4,5-Dehydro-L-Iduronic Acid
4,5-Dehydro-L-Iduronic Acid [drugbank:DB03569]

3-Butylthiolane 1-Oxide
3-Butylthiolane 1-Oxide [drugbank:DB02871]

Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. [PubChem]
Cinoxacin
Cinoxacin [drugbank:DB00827]

Digalactosyl Diacyl Glycerol (Dgdg)
Digalactosyl Diacyl Glycerol (Dgdg) [drugbank:DB03426]

(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid [drugbank:DB07302]

3-Amino-Alanine
3-Amino-Alanine [drugbank:DB03320]

Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Cefotaxime
Cefotaxime [drugbank:DB00493]

Temozolomide (Temodar and Temodal) is an oral alkylating agent used for the treatment of refractory anaplastic astrocytoma -- a type of cancerous brain tumor. Temozolomide is not active until it is converted at physiologic pH to the active form, 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC).
Temozolomide
Temozolomide [drugbank:DB00853]

N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide
N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide [drugbank:DB07619]

(2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE
(2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE [drugbank:DB06920]

Glycoluril
Glycoluril [drugbank:DB03533]

4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide
4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-Benzamide [drugbank:DB03039]

Trospium is a urinary antispasmodic. It is sold under the brand name Sanctura in the US, and as Trosec in Canada. [Wikipedia]
Trospium
Trospium [drugbank:DB00209]

N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide [drugbank:DB07734]

An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. [PubChem]
Ritonavir
Ritonavir [drugbank:DB00503]

Dimethyl Propionate Ester Heme
Dimethyl Propionate Ester Heme [drugbank:DB04009]

(S)-2-Amino-3-(6h-Selenolo[2,3-B]-Pyrrol-4-Yl)-Propionic Acid
(S)-2-Amino-3-(6h-Selenolo[2,3-B]-Pyrrol-4-Yl)-Propionic Acid [drugbank:DB03043]

ginsenoside C
ginsenoside C [drugbank:DB06748]

L-2-Amino-6-Methylene-Pimelic Acid
L-2-Amino-6-Methylene-Pimelic Acid [drugbank:DB02892]

ETC-588, or LUV (large unilamellar vesicles), is made of naturally occurring lipids that circulate through arteries to facilitate the role of high-density lipoprotein (HDL) in removing accumulated cholesterol and other lipids from cells including those in the arterial wall. LUV are capable of transporting excess cholesterol from the vasculature to the liver for eventual elimination as part of the reverse lipid transport (RLT) pathway. It is believed that the removal of cholesterol by ETC-588 through this pathway may result in the reversal of atherosclerosis. Esperion is currently developing ETC-588 as a treatment for patients with acute coronary syndromes.
ETC-588
ETC-588 [drugbank:DB05456]

A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Tetrabenazine
Tetrabenazine [drugbank:DB04844]

(3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE
(3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE [drugbank:DB07271]

Alpha-D-Mannose-6-Phosphate
Alpha-D-Mannose-6-Phosphate [drugbank:DB02900]

MF268
MF268 [drugbank:DB04021]

A peptide that is a homopolymer of glutamic acid. [PubChem]
L-Glutamic Acid
L-Glutamic Acid [drugbank:DB00142]

2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. [PubChem]
2'-Deoxyuridine
2'-Deoxyuridine [drugbank:DB02256]

S-Acetonylcysteine
S-Acetonylcysteine [drugbank:DB03858]

Gallium nitrate is a drug that is used to treat hyper-calcemia, or too much calcium in the blood. This condition may occur when individuals develop various types of cancer. Gallium nitrate is also known by the common brand name Ganite.
Gallium nitrate
Gallium nitrate [drugbank:DB05260]

(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL [drugbank:DB07933]

N-Acetylalanine
N-Acetylalanine [drugbank:DB02518]

N-(Sulfanylacetyl)Tyrosylprolylmethioninamide
N-(Sulfanylacetyl)Tyrosylprolylmethioninamide [drugbank:DB01883]

1-(N-Imidazolyl)-2-Hydroxy-2-(2,3-Dichlorophenyl)Octane
1-(N-Imidazolyl)-2-Hydroxy-2-(2,3-Dichlorophenyl)Octane [drugbank:DB02617]

CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE [drugbank:DB08526]

(2r)-2-(Aminomethyl)-2,4-Dihydroxy-5-Oxo-3-(2-Oxoethyl)-2,5-Dihydro-1h-Imidazol-3-Ium
(2r)-2-(Aminomethyl)-2,4-Dihydroxy-5-Oxo-3-(2-Oxoethyl)-2,5-Dihydro-1h-Imidazol-3-Ium [drugbank:DB01797]

3-Hydroxy-Myristic Acid
3-Hydroxy-Myristic Acid [drugbank:DB02767]

Tungstopterin Cofactor
Tungstopterin Cofactor [drugbank:DB04428]

ginkgolide-B
ginkgolide-B [drugbank:DB06744]

4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE
4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE [drugbank:DB08061]

Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Minaprine
Minaprine [drugbank:DB00805]

Sp-722
Sp-722 [drugbank:DB04503]

{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid [drugbank:DB01723]

[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid
[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid [drugbank:DB04204]

(1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol
(1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol [drugbank:DB08321]

Seocalcitol
Seocalcitol [drugbank:DB04258]

BV2
BV2 [drugbank:DB02574]

N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDE
N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDE [drugbank:DB07527]

A pyrazine that is used therapeutically as an antitubercular agent.
Pyrazinamide
Pyrazinamide [drugbank:DB00339]

Spaglumic acid is the Î²-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-Î±-aspartyl)-l-glutamic acid). In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer. Thus it is used in allergic conditions such as allergic conjunctivitis. Specifically spaglumic acid is approved in Portugal under the brand name Naabak and in Greece under the brand name Naaxia for use in patients with allergic conjunctivitis.
Spaglumic Acid
Spaglumic Acid [drugbank:DB08835]

AV411 is an orally bioavailable, centrally acting molecule that Avigen has identified as having potential utility for the treatment of neuropathic pain and other neurological indications, including opiate withdrawal. The active pharmaceutical ingredient in AV411 is ibudilast.
AV411
AV411 [drugbank:DB05066]

A four-carbon sugar that is found in algae, fungi, and lichens. It is twice as sweet as sucrose and can be used as a coronary vasodilator. [PubChem]
Meso-Erythritol
Meso-Erythritol [drugbank:DB04481]

S-2-(Boronoethyl)-L-Cysteine
S-2-(Boronoethyl)-L-Cysteine [drugbank:DB03731]

Antazoline is a 1st generation antihistamine that also anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
Antazoline
Antazoline [drugbank:DB08799]

2-Butyl-5,6-Dihydro-1h-Imidazo[4,5-D]Pyridazine-4,7-Dione
2-Butyl-5,6-Dihydro-1h-Imidazo[4,5-D]Pyridazine-4,7-Dione [drugbank:DB02441]

2,4,6-Tribromophenol
2,4,6-Tribromophenol [drugbank:DB02417]

Quinonoid 7,8-Tetrahydrobiopterin
Quinonoid 7,8-Tetrahydrobiopterin [drugbank:DB02562]

Dodecyl-Coa
Dodecyl-Coa [drugbank:DB03264]

4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol
4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol [drugbank:DB08356]

5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation. [PubChem]
Phosphoaminophosphonic Acid-Adenylate Ester
Phosphoaminophosphonic Acid-Adenylate Ester [drugbank:DB04395]

PXD101 is a novel investigational small molecule drug that inhibits the enzyme histone deacetylase (HDAC). PXD101 has been shown in preclinical studies to have the potential to treat a wide range of solid and hematologic malignancies either as a monotherapy or in combination with other active agents, and both an oral and intravenous formulation of the drug are being evaluated in clinical trials.
PXD101
PXD101 [drugbank:DB05015]

2-(Thiomethylene)-4-Methylpentanoic Acid
2-(Thiomethylene)-4-Methylpentanoic Acid [drugbank:DB02996]

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Acetohydroxamic Acid
Acetohydroxamic Acid [drugbank:DB00551]

An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. [PubChem]
Fluoxymesterone
Fluoxymesterone [drugbank:DB01185]

BF-200 ALA is under investigation by Biofrontera which shows positive results from its Phase IIb/III trial. According to Biofrontera, BF-200 ALA was strongly and significantly superior to placebo in the treatment of actinic keratosis.
BF-200 ALA
BF-200 ALA [drugbank:DB05365]

Fenethylline
Fenethylline [drugbank:DB01482]

Bovine adenosine deaminase derived from bovine intestine that has been extensively pegylated for extended serum half life.
Pegademase bovine
Pegademase bovine [drugbank:DB00061]

A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Thiethylperazine
Thiethylperazine [drugbank:DB00372]

An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. [PubChem]
Ethosuximide
Ethosuximide [drugbank:DB00593]

The anti-obesity drug, V24343, acts by targeting the CB1 receptor in the brain and suppressing a person's appetite.
V24343 [drugbank:DB05201]

Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine
Cyclopropyl-{4-[5-(3,4-Dichlorophenyl)-2-[(1-Methyl)-Piperidin]-4-Yl-3-Propyl-3h-Imidazol-4-Yl]-Pyrimidin-2-Yl}Amine [drugbank:DB03084]

5-benzyl-1,3-thiazol-2-amine
5-benzyl-1,3-thiazol-2-amine [drugbank:DB08114]

8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine [drugbank:DB02550]

ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID [drugbank:DB07895]

CDX-110 is developed by Celldex Therapeutics for the treatment of EGFRvIII expressing Glioblastoma Multiforme (GBM). GBM is the most common and aggressive form of brain cancer. CDX-110 is an immunotherapy that targets the tumor-specific growth promoter EGFRvIII.
CDX-110
CDX-110 [drugbank:DB05374]

An intermediate in testosterone biosynthesis, found in the testis or the adrenal glands. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), is converted to testosterone by the oxidation of the 3-beta hydroxyl group to a 3-keto group (3-hydroxysteroid dehydrogenases). [PubChem]
5-Androstenediol
5-Androstenediol [drugbank:DB01524]

Gallium maltolate is Titanâs novel oral agent in development for the potential treatment of chronic bacterial infections, bone disease and cancer.
gallium maltolate
gallium maltolate [drugbank:DB05420]

Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors.
Carvedilol
Carvedilol [drugbank:DB01136]

2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid
2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid [drugbank:DB03670]

Pentanal
Pentanal [drugbank:DB01919]

(1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
(1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol [drugbank:DB08129]

O3-Sulfonylgalactose
O3-Sulfonylgalactose [drugbank:DB01818]

Retapamulin is a topical antibiotic developed by GlaxoSmithKline. It was approved by the United States Food and Drug Administration in April 2007 for the treatment of bacterial skin infections such as impetigo. It is marketed as an ointment under the name brand Altabax.
Retapamulin
Retapamulin [drugbank:DB01256]

METHYL N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-ISOPROPYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE
METHYL N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-ISOPROPYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE [drugbank:DB08670]

(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID [drugbank:DB07136]

WL-1002 is developed by Winston Laboratories which is a topical cream formulation of 075% zucapaicin (also known as civamide), for the treatment of pain due to osteoarthritis.
WL-1002 [drugbank:DB05346]

Clocapramine is an atypical antipsychotic of the imidobenzyl class which was introduced in Japan in 1974 for the treatment of schizophrenia. In addition to psychosis, clocapramine has also been used to augment antidepressants in the treatment of anxiety and panic. Clocapramine has been implicated in at least one strange death, including a suicide.
Clocapramine
Clocapramine [drugbank:DB09003]

4-Methylimidazole
4-Methylimidazole [drugbank:DB03385]

L-Xylopyranose
L-Xylopyranose [drugbank:DB03911]

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. [PubChem]
Teniposide
Teniposide [drugbank:DB00444]

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. [PubChem]
Methotrexate
Methotrexate [drugbank:DB00563]

Vapreotide is a synthetic octapeptide somatostatin analog. It was being studied for the treatment of cancer.
Vapreotide
Vapreotide [drugbank:DB04894]

Tazobactam Trans-Enamine Intermediate
Tazobactam Trans-Enamine Intermediate [drugbank:DB03445]

GTI-2501 is a novel antisense drug which has shown a favorable safety profile in preclinical studies, and in a phase I clinical trial. The drug is in a phase II clinical trial in combination with docetaxel for the treatment of hormone refractory prostate cancer. Initial testing has demonstrated strong antitumor activity in preclinical studies in prostate cancer and a variety of other tumor types.
GTI-2501
GTI-2501 [drugbank:DB05406]

{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID
{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACID [drugbank:DB06989]

Trihydroxyantimonite(Iii)
Trihydroxyantimonite(Iii) [drugbank:DB02453]

MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation. Trials will initially focus on studies to treat glioblastoma, a cancer of the central nervous system. Other possible indications include chronic obstructive pulmonary disease (COPD) and pustular dermatoses. In pre-clinical studies, HuMax-Inflam has been shown to inhibit tumor growth in tumor models using primary human tumors in immunodeficient mice. HuMax-Inflam was also effective in reducing disease activity in palmoplantar pustulosis patients in a clinical study.
MDX-018
MDX-018 [drugbank:DB05484]

4-(4-Chlorophenyl)Imidazole
4-(4-Chlorophenyl)Imidazole [drugbank:DB02974]

4-(4-FLUOROBENZYL)PIPERIDINE
4-(4-FLUOROBENZYL)PIPERIDINE [drugbank:DB07110]

Metharbital was patented in 1905 by Emil Fischer working for Merck. It was marketed as Gemonil by Abbott Laboratories. It is a barbiturate anticonvulsant, used in the treatment of epilepsy. It has similar properties to phenobarbital [Wikipedia].
Metharbital
Metharbital [drugbank:DB00463]

Reduced Fab fragment of the murine IgG1 monoclonal antibody IMMU-4 (also called NP-4) with specificity for carcinoembryonic antigen (CEA) covalently labeled with Technitium 99. The molecule has a molecular weight of ~54,000 Daltons.
Arcitumomab
Arcitumomab [drugbank:DB00113]

Intravenous immunoglobulin (IVIg) is a mixture of IgG1 and other antibodies derived from healthy human plasma via Cohn fractionation. The purification process includes cold alcohol fractionation, polyethylene glycol precipitation, and ion exchange chromatography. IVIg contains the same distribution of IgG antibody subclasses as is found in the general human population. IgG subclasses are fully represented in the following proportions: 70.3% IgG1, 24.7% IgG2, 3.1% IgG3, and 1.9% IgG4. IVIg is used in the treatment of immunodeficiencies, as well as autoimmune and inflammatory disorders.
Intravenous Immunoglobulin
Intravenous Immunoglobulin [drugbank:DB00028]

OMS103HP is the first drug being developed to improve joint function following arthroscopic surgery, one of the most common procedures performed today by orthopedic surgeons.
OMS-103HP
OMS-103HP [drugbank:DB05303]

3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL
3-{3-[(DIMETHYLAMINO)METHYL]-1H-INDOL-7-YL}PROPAN-1-OL [drugbank:DB08447]

A phosphodiesterase inhibitor with antidepressant properties. [PubChem]
(R)-Rolipram
(R)-Rolipram [drugbank:DB04149]

1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One
1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One [drugbank:DB02170]

N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane
N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane [drugbank:DB04126]

ADX10059 is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM). The orally available small molecule drug candidate, which is highly specific for mGluR5, was discovered at Addex in 2003. It is developed for the treatment of GERD, migraine and anxiety.
ADX10059 [drugbank:DB05070]

Debromohymenialdisine
Debromohymenialdisine [drugbank:DB04367]

CYT997 is an orally available vascular argeting and cytotoxic agent that has proven effective in animal models of a wide range of tumour types including breast, prostate and colon, as well as some leukemias.
CYT997
CYT997 [drugbank:DB05147]

2-Amino-3-Ketobutyric Acid
2-Amino-3-Ketobutyric Acid [drugbank:DB03915]

ISS 1018 is a short, synthetic, unmethylated CpG oligodeoxynucleotide (CpG ODN) with immunostimulatory activity. ISS 1018 signals through Toll-like receptor 9 (TLR9) to induce the production of immunoglobulin by B cells and interferon (IFN) -alpha, IFN-beta, interleukin-12 (IL-12), and tumor necrosis factor - alpha (TNF-alpha) by plasmacytoid dendritic cells (pDC). ISS 1018 CpG ODN promotes antigen presentation and co-stimulatory molecule expression. ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent Hepatitis B in adults. It is also being investigated in combination with rituximab for treatment of b-cell or non-hodgkin's lymphoma.
ISS-1018
ISS-1018 [drugbank:DB05463]

3'-Azido-3'-Deoxythymidine-5'-Monophosphate
3'-Azido-3'-Deoxythymidine-5'-Monophosphate [drugbank:DB03666]

Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. [Wikipedia]
Nitroprusside
Nitroprusside [drugbank:DB00325]

All-Trans Axerophthene
All-Trans Axerophthene [drugbank:DB01770]

A widely used industrial solvent. [PubChem]
Toluene
Toluene [drugbank:DB01900]

Pantothenyl-Aminoethanol-Acetate Pivalic Acid
Pantothenyl-Aminoethanol-Acetate Pivalic Acid [drugbank:DB03045]

Coelenteramide
Coelenteramide [drugbank:DB04049]

2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide [drugbank:DB06997]

2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL
2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL [drugbank:DB08217]

4-(Acetylamino)-3-Amino Benzoic Acid
4-(Acetylamino)-3-Amino Benzoic Acid [drugbank:DB02268]

N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID
N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID [drugbank:DB04767]

Hyperforin is a phytochemical produced by some of the members of the plant genus Hypericum, notably Hypericum perforatum (St John's wort).
Hyperforin
Hyperforin [drugbank:DB01892]

4-acetamidobenzoic acid
4-acetamidobenzoic acid [drugbank:DB04500]

An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. [PubChem]
Tioguanine
Tioguanine [drugbank:DB00352]

A phenothiazine antipsychotic with effects similar to chlorpromazine. [PubChem]
Mesoridazine
Mesoridazine [drugbank:DB00933]

5'-Deoxy-5'-Methylthioadenosine
5'-Deoxy-5'-Methylthioadenosine [drugbank:DB02282]

Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3.
Liotrix
Liotrix [drugbank:DB01583]

Raxibacumab is a human IgG1Î» monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. Raxibacumab has a molecular weight of approximately 146 kilodaltons. Raxibacumab is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012.
Raxibacumab
Raxibacumab [drugbank:DB08902]

3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide
3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide [drugbank:DB07179]

2,3-Difluorobenzyl Alcohol
2,3-Difluorobenzyl Alcohol [drugbank:DB04312]

2'-Deoxyinosine
2'-Deoxyinosine [drugbank:DB02380]

A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. [PubChem]
Granisetron
Granisetron [drugbank:DB00889]

Bopindolol (INN) is a beta blocker. It is an ester which acts as a prodrug for "pindolol":http://drugbank.ca/drugs/DB00960.
Bopindolol
Bopindolol [drugbank:DB08807]

Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide, by 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) and by sulphate. These results are consistent with the transport of glisoxepide via the transport system for the unconjugated bile acid cholate. (PMID:1618280, 9017793)
Glisoxepide
Glisoxepide [drugbank:DB01289]

(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid [drugbank:DB06905]

5-[Bis-2(Chloro-Ethyl)-Amino]-2,4-Dintro-Benzamide
5-[Bis-2(Chloro-Ethyl)-Amino]-2,4-Dintro-Benzamide [drugbank:DB03228]

4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol
4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol [drugbank:DB07601]

(S)-2-Amino-3-(4h-Selenolo[3,2-B]-Pyrrol-6-Yl)-Propionic Acid
(S)-2-Amino-3-(4h-Selenolo[3,2-B]-Pyrrol-6-Yl)-Propionic Acid [drugbank:DB03513]

XL147 is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).
XL147
XL147 [drugbank:DB05240]

Conjugated estrogens, a mixture of the water-soluble salts of sulfate esters from estrone, equilin, 17 Î±-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics.
Conjugated Estrogens
Conjugated Estrogens [drugbank:DB00286]

Dimethylallyl Diphosphate
Dimethylallyl Diphosphate [drugbank:DB01785]

L-Tryptophanamide
L-Tryptophanamide [drugbank:DB04537]

Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of carotenoids found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. [PubChem]
Vitamin A
Vitamin A [drugbank:DB00162]

8-Methyl-9-Oxoguanine
8-Methyl-9-Oxoguanine [drugbank:DB02993]

Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function. [PubChem]
Carbenicillin
Carbenicillin [drugbank:DB00578]

7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine
7-(2,5-dihydropyrrol-1-yl)-6-phenyl-pyrido[6,5-d]pyrimidin-2-amine [drugbank:DB08146]

(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE [drugbank:DB08073]

Felbamate is an anticonvulsant drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites.
Felbamate
Felbamate [drugbank:DB00949]

An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Flutamide
Flutamide [drugbank:DB00499]

NAM NAPTHYLAMINOALANINE
NAM NAPTHYLAMINOALANINE [drugbank:DB08253]

5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE
5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE [drugbank:DB07167]

N-Propyl-Tartramic Acid
N-Propyl-Tartramic Acid [drugbank:DB03390]

N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide [drugbank:DB07101]

N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide [drugbank:DB03878]

(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE [drugbank:DB08515]

Dimenhydrinate (Dramamine, Gravol and Vertirosan) is an over-the-counter drug used to prevent motion sickness. It is closely related to diphenhydramine HCl, or Benadryl. It is primarily a H1-antagonist, but also possesses an antimuscarinic effect.
Dimenhydrinate
Dimenhydrinate [drugbank:DB00985]

3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide
3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide [drugbank:DB03311]

Heparin Disaccharide Iii-S
Heparin Disaccharide Iii-S [drugbank:DB02353]

Bis-Benzamidine
Bis-Benzamidine [drugbank:DB02081]

Letrozole (INN, trade name FemaraÂ®) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer

Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Letrozole blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids. In contrast, the antiestrogenic action of tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production. Letrozole is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women. Side effects include signs and symptoms of hypoestrogenism. There is concern that long term use may lead to osteoporosis, which is why prescriptions of Letrozole are often accompanied by prescriptions of osteoporosis-fighting medication such as Fosamax. Letrozole has shown to reduce estrogen levels by 98 percent while raising testosterone levels. The anti-estrogen action of letrozole is preferred by athletes and bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids. Usage above 2.5 mg/day is known to potentially temporarily kill sex drive. Above 5mg/day for extended periods may cause kidney problems.

Letrozole has also been shown to delay the fusing of the growth plates in adolescents. This may boost the effectiveness of growth hormone, and thus Letrozole is used to treat adolescents and children with short stature.

Letrozole
Letrozole [drugbank:DB01006]

2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide [drugbank:DB07194]

deoxycytidylyl-3',5'-guanosine
deoxycytidylyl-3',5'-guanosine [drugbank:DB03326]

A synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. It is usually supplied in a racemic mixture (Norgestrel, 6533-00-2). Only the levonorgestrel isomer is active. Levonorgestrel is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Triphasil, and Min-Ovral.
Levonorgestrel
Levonorgestrel [drugbank:DB00367]

5-(5-(4-(4,5-DIHYDRO-2-OXAZOLY)PHENOXY)PENTYL)-3-METHYL ISOXAZOLE
5-(5-(4-(4,5-DIHYDRO-2-OXAZOLY)PHENOXY)PENTYL)-3-METHYL ISOXAZOLE [drugbank:DB08720]

(5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime
(5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime [drugbank:DB08197]

(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one
(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one [drugbank:DB07431]

A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Albendazole
Albendazole [drugbank:DB00518]

2-(4-DIMETHYLAMINOPHENYL)DIAZENYLBENZOIC ACID
2-(4-DIMETHYLAMINOPHENYL)DIAZENYLBENZOIC ACID [drugbank:DB08209]

The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic. [PubChem]
Taurocholic Acid
Taurocholic Acid [drugbank:DB04348]

ADC4022 is an investigational medicine for the treatment of Chronic Obstructive Pulmonary Disease (COPD) and severe asthma.
ADC4022
ADC4022 [drugbank:DB05195]

7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE
7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE [drugbank:DB07512]

O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE
O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE [drugbank:DB07351]

Lambda-Bis(2,2'-Bipyridine)-(5-Methyl-2-2'-Bipyridine)-C9-Adamantane Ruthenium (Ii)
Lambda-Bis(2,2'-Bipyridine)-(5-Methyl-2-2'-Bipyridine)-C9-Adamantane Ruthenium (Ii) [drugbank:DB01663]

N5-Iminoethyl-L-Ornithine
N5-Iminoethyl-L-Ornithine [drugbank:DB03305]

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (receptors, N-methyl-D-aspartate). As a drug of abuse, it is known as PCP and Angel Dust. [PubChem]
Phencyclidine
Phencyclidine [drugbank:DB03575]

Tasosartan is a long-acting angiotensin II (AngII) receptor blocker. Its long duration of action has been attributed to its active metabolite enoltasosartan. It is used to treat patients with essential hypertension
Tasosartan
Tasosartan [drugbank:DB01349]

Dihydroorotic Acid
Dihydroorotic Acid [drugbank:DB02129]

4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE
4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE [drugbank:DB04673]

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE. [PubChem]
D-Cysteine
D-Cysteine [drugbank:DB03201]

NV-18 is a product of the Novogen diphenolic synthetic analogue program that is creating drugs with diverse activities against specific types of cancer. Like phenoxodiol, NV-18 is broadly effective in the laboratory against almost all human cancer types, but NV-18 is distinctive in showing particular potency against melanoma and cholangiocarcinoma (cancer of the gall bladder).
NV-18
NV-18 [drugbank:DB05886]

Follitropin beta is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin beta is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature âbetaâ differentiates it from another recombinant human FSH product that was marketed earlier as follitropin alpha. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH.
Follitropin beta
Follitropin beta [drugbank:DB00066]

(2s,4s)-Alpha-Campholinic Acid
(2s,4s)-Alpha-Campholinic Acid [drugbank:DB02906]

CRA_1144
CRA_1144 [drugbank:DB03643]

PI-88 is a mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity.
PI-88
PI-88 [drugbank:DB05808]

9-(6-Deoxy-Beta-D-Allofuranosyl)-6-Methylpurine
9-(6-Deoxy-Beta-D-Allofuranosyl)-6-Methylpurine [drugbank:DB03952]

2-[(1R)-2-carboxy-1-(naphthalen-1-ylmethyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
2-[(1R)-2-carboxy-1-(naphthalen-1-ylmethyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid [drugbank:DB08731]

(5-Methyl-6-Oxo-1,6-Dihydro-Pyridin-3-Yl)-1,2-Dideoxy-Ribofuranose-5-Monophosphate
(5-Methyl-6-Oxo-1,6-Dihydro-Pyridin-3-Yl)-1,2-Dideoxy-Ribofuranose-5-Monophosphate [drugbank:DB04060]

Tri-Chloro-Acetaldehyde
Tri-Chloro-Acetaldehyde [drugbank:DB02650]

3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE
3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE [drugbank:DB07075]

7-METHOXY-1-METHYL-9H-BETA-CARBOLINE
7-METHOXY-1-METHYL-9H-BETA-CARBOLINE [drugbank:DB07919]

L-Valinol
L-Valinol [drugbank:DB04383]

Eprazinone (trade name Eftapan) is a mucolytic drug, and relieves bronchospasms.
Eprazinone
Eprazinone [drugbank:DB08990]

N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine
N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine [drugbank:DB08057]

6-Methyl-Formycin A
6-Methyl-Formycin A [drugbank:DB03986]

Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug. It is an alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. [Wikipedia]
Rescinnamine
Rescinnamine [drugbank:DB01180]

4-Hydroxy-L-Threonine-5-Monophosphate
4-Hydroxy-L-Threonine-5-Monophosphate [drugbank:DB02609]

1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE [drugbank:DB04685]

The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States. [PubChem]
Porfimer
Porfimer [drugbank:DB00707]

5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE
5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE [drugbank:DB07636]

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Sulfasalazine
Sulfasalazine [drugbank:DB00795]

17Alpha-methyl-delta1-dihydrotestosterone
17Alpha-methyl-delta1-dihydrotestosterone [drugbank:DB01572]

4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline
4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline [drugbank:DB02984]

(3s,6s,9r,10r,11s,12s,13e,15e,18s,21s)-18-{(1e,3e,7s,8s)-9-[(2s,3r,4s,5s,6r,9s,11s)-9-Ethyl-4-Hydroxy-3,5,11-Trimethyl-8-Oxo-1-Oxa-7-Azaspiro[5.5]Undec-2-Yl]-8-Hydroxy-1,7-Dimethylnona-1,3-Dienyl}-10,12-Dihydroxy-3-(3-Hydroxybenzyl)-6-Isopropyl-11-Methyl- [drugbank:DB03393]

Asimadoline is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline is an orally administered agent that acts as a kappa opioid receptor agonist. It has shown encouraging clinical efficacy for the treatment of IBS in a barostat study in IBS patients and has the potential for treating other gastrointestinal diseases.
Asimadoline
Asimadoline [drugbank:DB05104]

1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine [drugbank:DB08053]

Sulodexide is a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH).
Sulodexide
Sulodexide [drugbank:DB06271]

(2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
(2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine [drugbank:DB07003]

N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamide
N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamide [drugbank:DB06868]

Fidarestat
Fidarestat [drugbank:DB02021]

N-(3-CARBOXYPROPANOYL)-L-NORVALINE
N-(3-CARBOXYPROPANOYL)-L-NORVALINE [drugbank:DB08554]

RTA 744 is a novel anthracycline derivative that crosses the blood-brain barrier and shows significant potential for the treatment of primary and metastatic brain cancers. Anthracyclines are one of the most broadly used and effective classes of cancer therapies; however, they are not used to treat brain cancers because current therapies do not cross the blood-brain barrier.
RTA 744
RTA 744 [drugbank:DB05920]

Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved on July 20, 2012.
Carfilzomib
Carfilzomib [drugbank:DB08889]

RU85493 [drugbank:DB01908]

3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID [drugbank:DB07916]

2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID
2-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACID [drugbank:DB08181]

N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea
N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea [drugbank:DB03782]

Valsartan is an angiotensin-receptor blocker (ARB) that may be used to treat a variety of cardiac conditions including hypertension, diabetic nephropathy and heart failure. Valsartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Valsartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.
Valsartan
Valsartan [drugbank:DB00177]

Sitagliptin is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. The drug works to competitively inhibit a protein/enzyme, dipeptidyl peptidase 4 (DPP-4), that results in an increased amount of active incretins (GLP-1 and GIP), reduced amount of release of glucagon (diminishes its release) and increased release of insulin.
Sitagliptin
Sitagliptin [drugbank:DB01261]

3-Methylpyridine
3-Methylpyridine [drugbank:DB01996]

Follitropin alpha is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Follitropin alpha was the worldâs first recombinant human FSH preparation and is produced in genetically engineered Chinese hamster cell lines (CHO). The nomenclature âalphaâ differentiates it from another recombinant human FSH product that was marketed later as follitropin beta. Follitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Follitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). Numerous physio-chemical tests and bioassays indicate that follitropin beta and follitropin alpha are indistinguishable. However, a more recent study showed there is may be a slight clinical difference, with the alpha form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural human follicle stimulating hormone (FSH). Further, the ogliosaccharide side chains are very similar, but not completely identical to that of natural FSH. However, these small differences do not affect the bioactivity compared to natural FSH.
Follitropin Alpha
Follitropin Alpha [drugbank:DB09024]

Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester
Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester [drugbank:DB02161]

(3Z,5S,6R,7S,8R,8aS)-3-(octylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-5,6,7,8-tetrol
(3Z,5S,6R,7S,8R,8aS)-3-(octylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-5,6,7,8-tetrol [drugbank:DB07370]

1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL
1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL [drugbank:DB07061]

Bicine
Bicine [drugbank:DB03709]

2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol
2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol [drugbank:DB01998]

19-Norandrostenedione refers to two steroid isomers that were once marketed as dietary supplements and mainly used by body builders. After 2005, 19-Norandrostenedione was regulated in the United States as a schedule III controlled substance, as well as banned from use in competitive sports by the World Anti-Doping Agency.

In the body 19-norandrostenedione is rapidly metabolized into nandrolone, also known as nortestosterone.

19-norandrostenedione
19-norandrostenedione [drugbank:DB01434]

3-(4-nitrophenyl)-1H-pyrazole
3-(4-nitrophenyl)-1H-pyrazole [drugbank:DB08695]

Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. [PubChem]
Piperacillin
Piperacillin [drugbank:DB00319]

Double Oxidized Cysteine
Double Oxidized Cysteine [drugbank:DB01769]

Formic Acid Benzyl Ester
Formic Acid Benzyl Ester [drugbank:DB04569]

3-{[(1r)-1-Benzyl-2-Sulfanylethyl]Amino}-3-Oxopropanoic Acid
3-{[(1r)-1-Benzyl-2-Sulfanylethyl]Amino}-3-Oxopropanoic Acid [drugbank:DB01935]

4,6-O-(1-CARBOXYETHYLIDENE)-BETA-D-MANNOSE-(1->4)-BETA-D-GLUCURONIC ACID
4,6-O-(1-CARBOXYETHYLIDENE)-BETA-D-MANNOSE-(1->4)-BETA-D-GLUCURONIC ACID [drugbank:DB04596]

Beta-hydroxyfentanyl
Beta-hydroxyfentanyl [drugbank:DB01453]

2-[2-(4-CHLORO-PHENYLSULFANYL)-ACETYLAMINO]-3-(4-GUANIDINO-PHENYL)-PROPIONAMIDE
2-[2-(4-CHLORO-PHENYLSULFANYL)-ACETYLAMINO]-3-(4-GUANIDINO-PHENYL)-PROPIONAMIDE [drugbank:DB07105]

(1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID
(1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID [drugbank:DB08551]

2,3-Bis-Benzo[1,3]Dioxol-5-Ylmethyl-Succinic Acid
2,3-Bis-Benzo[1,3]Dioxol-5-Ylmethyl-Succinic Acid [drugbank:DB02154]

6-Hydroxy-1,6-Dihydro Purine Nucleoside
6-Hydroxy-1,6-Dihydro Purine Nucleoside [drugbank:DB03015]

R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid
R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid [drugbank:DB04416]

Cogane (PYM50028/P58, p59, p63) is a novel non-peptide, orally bioavailable neurotrophic factor inducer that readily reverses free radical neurotoxicity produced by 1-ethyl-4- phenylpyridium (MPP+) in dopaminergic neurones and reverses the decrease of neuronal growth factors and dopamine receptors in the brain. Pre-clinical work with Cogane showed it to be neuroprotective against betya-amyloid and glutamate damage which contributes to Alzheimer's disease and reverses the changes in the area of the brain involved in Parkinsonâs disease.

P58 is a protein synthesis stimulant acts by restoring levels of proteins that are altered in the ageing brain, reversing the loss of nerve receptors in the ageing brain and potentially allowing for the regrowth of neural connections. P58 therefore provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain. P58 is one of a family of phytochemicals (Cogane) isolated from traditional treatments for the elderly that have previously been shown to offer significant benefit in the treatment of senile dementia.

PYM50028 [drugbank:DB05450]

N''-{3-[(3s,8ar)-1,4-Dioxooctahydropyrrolo[1,2-a]Pyrazin-3-Yl]Propyl}Guanidine
N''-{3-[(3s,8ar)-1,4-Dioxooctahydropyrrolo[1,2-a]Pyrazin-3-Yl]Propyl}Guanidine [drugbank:DB04433]

CRA_16847 [drugbank:DB02063]

(2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID
(2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID [drugbank:DB08640]

Alpha-methylthiofentanyl
Alpha-methylthiofentanyl [drugbank:DB01470]

4-(6-CHLORO-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL) BUTYL PHOSPHATE
4-(6-CHLORO-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL) BUTYL PHOSPHATE [drugbank:DB08016]

N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE [drugbank:DB07231]

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. [PubChem]
Dimethyl sulfoxide
Dimethyl sulfoxide [drugbank:DB01093]

Amigal (migalastat hydrochloride) is an experimental, oral therapy for the treatment of Fabry disease and belongs to a class of molecules known as pharmacological chaperones.
Migalastat
Migalastat [drugbank:DB05018]

Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections. It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress. Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4.
Bavituximab
Bavituximab [drugbank:DB05136]

FR230513 [drugbank:DB03572]

(2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine
(2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine [drugbank:DB07980]

Diloxanide furoate is an anti-protozoal drug used in the treatment of Entamoeba histolytica and some other protozoal infections. Although it is not currently approved for use in the United States, it was approved by a CDC study in the treatment of 4,371 cases of Entamoeba histolytica from 1977 to 1990.
Diloxanide
Diloxanide [drugbank:DB08792]

(2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
(2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide [drugbank:DB07039]

N-(4-{[amino(imino)methyl]amino}butyl)-2,4'-bi-1,3-thiazole-4-carboxamide
N-(4-{[amino(imino)methyl]amino}butyl)-2,4'-bi-1,3-thiazole-4-carboxamide [drugbank:DB07499]

5-Nitro-6-Ribityl-Amino-2,4(1h,3h)-Pyrimidinedione
5-Nitro-6-Ribityl-Amino-2,4(1h,3h)-Pyrimidinedione [drugbank:DB04162]

2'-DEOXY-5-FORMYLCYTIDINE-5'-MONOPHOSPHATE
2'-DEOXY-5-FORMYLCYTIDINE-5'-MONOPHOSPHATE [drugbank:DB04603]

Hydroxyethylcysteine
Hydroxyethylcysteine [drugbank:DB02413]

1,2-Di-N-Pentanoyl-Sn-Glycero-3-Dithiophosphocholine
1,2-Di-N-Pentanoyl-Sn-Glycero-3-Dithiophosphocholine [drugbank:DB02225]

3r-Hydroxydecanoyl-Coa
3r-Hydroxydecanoyl-Coa [drugbank:DB03192]

N-Dimethyl-Lysine
N-Dimethyl-Lysine [drugbank:DB03362]

Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis. [Wikipedia]
Emedastine
Emedastine [drugbank:DB01084]

Cathine (Î²-hydroxyamphetamine) is a monoamine alkaloid found in the shrub Catha edulis (khat). Cathine is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance. [Wikipedia]
Cathine
Cathine [drugbank:DB01486]

Tumor necrosis factor (TNF-alpha) binding antibody (chimeric IgG1). It is composed of human constant and murine variable regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion
Infliximab
Infliximab [drugbank:DB00065]

5-(4-FLUOROPHENYL)-3-{[(4-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID
5-(4-FLUOROPHENYL)-3-{[(4-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID [drugbank:DB07770]

EPT1647 (Melanotan) is an analog of the peptide hormone alpha-melanocyte stimulating hormone (alpha-MSH) that tends to induce skin tanning. It is being developed by the Australian company Clinuvel Pharmaceuticals (previously known as EpiTan).
EPT1647
EPT1647 [drugbank:DB04931]

Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane. Like most volatile amines, it possesses the somewhat unpleasant odour of rotten fish. It ignites readily, burning with a smoky flame characteristic of aromatic compounds. Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples.
Aniline
Aniline [drugbank:DB06728]

N-Benzoyl-N'-Beta-D-Glucopyranosyl Urea
N-Benzoyl-N'-Beta-D-Glucopyranosyl Urea [drugbank:DB04295]

A cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. It has been proposed for the treatment of asthma, rhinitis, skin allergies, and anaphylaxis. [PubChem]
Ketotifen
Ketotifen [drugbank:DB00920]

A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
Lactic Acid
Lactic Acid [drugbank:DB04398]

Atomoxetine is the first non-stimulant drug approved for the treatment of attention-deficit hyperactivity disorder (ADHD). It is sold in the form of the hydrochloride salt of atomoxetine. This chemical is manufactured and marketed under the brand name Strattera; by Eli Lilly and Company and as a generic Attentin by Torrent Pharmaceuticals. There is currently no generic available within the United States due to patent restrictions. [Wikipedia]
Atomoxetine
Atomoxetine [drugbank:DB00289]

2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2N-METHYL-2H-TETRAZOL-5-YL]-PHENOL
2,6-DIMETHYL-1-(3-[3-METHYL-5-ISOXAZOLYL]-PROPANYL)-4-[2N-METHYL-2H-TETRAZOL-5-YL]-PHENOL [drugbank:DB08713]

7,8-dihydro-6-hydroxymethyl-7-methyl-7-[2-phenylethyl]-pterin
7,8-dihydro-6-hydroxymethyl-7-methyl-7-[2-phenylethyl]-pterin [drugbank:DB04610]

3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol [drugbank:DB06897]

Amylamine
Amylamine [drugbank:DB02045]

4,5-Dehydro-D-Glucuronic Acid
4,5-Dehydro-D-Glucuronic Acid [drugbank:DB02305]

3-[N-[Benzyloxycarbonyl]-Phenylalaninyl-Amino]-5-Phenyl-Pentane-1-Sulfonic Acid 4-Nitro-Phenyl Ester
3-[N-[Benzyloxycarbonyl]-Phenylalaninyl-Amino]-5-Phenyl-Pentane-1-Sulfonic Acid 4-Nitro-Phenyl Ester [drugbank:DB02051]

2,6-dibromo-4-phenoxyphenol
2,6-dibromo-4-phenoxyphenol [drugbank:DB08103]

2-(N-Morpholino)-Ethanesulfonic Acid
2-(N-Morpholino)-Ethanesulfonic Acid [drugbank:DB03814]

3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID
3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID [drugbank:DB04593]

(2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
(2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide [drugbank:DB07559]

(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine [drugbank:DB04012]

2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid
2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid [drugbank:DB06985]

Flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
Flumethasone Pivalate
Flumethasone Pivalate [drugbank:DB00663]

AP1903
AP1903 [drugbank:DB04974]

A synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation. [PubChem]
Dydrogesterone
Dydrogesterone [drugbank:DB00378]

Hexafluronium bromide is a neuromuscular blocking agent used in anesthesiology to prolong and potentiate the skeletal muscle relaxing action of suxamethonium during surgery. It is known to bind and block the activity of plasma cholinesterases.
Hexafluronium
Hexafluronium [drugbank:DB00941]

Ivacaftor (also known as Kalydeco or VX-770) is a drug for the treatment of cystic fibrosis, developed by Vertex Pharmaceuticals and the Cystic Fibrosis Foundation. FDA approved on January 31, 2012.
Ivacaftor
Ivacaftor [drugbank:DB08820]

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. [PubChem]
Ketamine
Ketamine [drugbank:DB01221]

7-amino-2-tert-butyl-4-{[2-(1H-imidazol-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidine-6-carboxamide
7-amino-2-tert-butyl-4-{[2-(1H-imidazol-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidine-6-carboxamide [drugbank:DB07042]

5-beta-DIHYDROTESTOSTERONE
5-beta-DIHYDROTESTOSTERONE [drugbank:DB07447]

Phensuximide is an anticonvulsant in the succinimide class. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex.
Phensuximide
Phensuximide [drugbank:DB00832]

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.
Bethanidine
Bethanidine [drugbank:DB00217]

(4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium
(4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium [drugbank:DB02673]

D-Myo-Inositol-Hexasulphate
D-Myo-Inositol-Hexasulphate [drugbank:DB01666]

Any of a class of cerebroside sulfuric esters, they are found largely in the medullated nerve fibers and may accumulate in metachromatic leukodystrophy.
Sulfatide
Sulfatide [drugbank:DB04780]

A five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener. [PubChem]
D-Xylitol
D-Xylitol [drugbank:DB01904]

4-Deoxyglucarate
4-Deoxyglucarate [drugbank:DB03212]

2,3,-Dihydroxybenzoylserine
2,3,-Dihydroxybenzoylserine [drugbank:DB02710]

A thioxanthene-based neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Zuclopenthixol is not approved for use in the United States.
Zuclopenthixol
Zuclopenthixol [drugbank:DB01624]

Tirapazamine (SR-4233) is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen (hypoxia). Such levels are common in human solid tumors, a phenomenon known as tumor hypoxia. Thus, tirapazamine is activated to its toxic form preferentially in the hypoxic areas of solid tumors. Cells in these regions are resistant to killing by radiotherapy and most anticancer drugs. Thus the combination of tirapazamine with conventional anticancer treatments is particularly effective. As of 2006, tirapazamine is undergoing phase III testing in patients with head and neck cancer and gynecological cancer, and similar trials are being undertaken for other solid tumor types. [Wikipedia]
Tirapazamine
Tirapazamine [drugbank:DB04858]

4,4'-PROPANE-2,2-DIYLDIPHENOL
4,4'-PROPANE-2,2-DIYLDIPHENOL [drugbank:DB06973]

Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It is a synthetic cannabinoid, which mimics the main ingredient of marijuana (THC) but it has more predictable side effects and causes no or minimal euphoria. Nabilone is not derived from the cannabis plant as is dronabinol.

In Canada, the United States, the United Kingdom and Mexico, nabilone is marketed as Cesamet. It was approved in 1985 by the United States FDA for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics. Though it was approved by the FDA in 1985, the drug only began marketing in the United States in 2006. It is also approved for use in treatment of anorexia and weight loss in patients with AIDS.

Although it doesn't have the official indication (except in Mexico), nabilone is widely used as an adjunct therapy for chronic pain management. Numerous trials and case studies have demonstrate various benefits for condition such as fibromyalgia and multiple scerosis.

Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers ("trans").

Nabilone
Nabilone [drugbank:DB00486]

1-[Glycerolylphosphonyl]-2-[8-(2-Hexyl-Cyclopropyl)-Octanal-1-Yl]-3-[Hexadecanal-1-Yl]-Glycerol
1-[Glycerolylphosphonyl]-2-[8-(2-Hexyl-Cyclopropyl)-Octanal-1-Yl]-3-[Hexadecanal-1-Yl]-Glycerol [drugbank:DB03979]

An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis. [PubChem]
Quisqualate
Quisqualate [drugbank:DB02999]

Uridine-2',3'-Vanadate
Uridine-2',3'-Vanadate [drugbank:DB03512]

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure.

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID) and induces apoptosis in cancer cells. It is also potential replacement for aspirin for people sensitive to it.

Salicylate-sodium
Salicylate-sodium [drugbank:DB01398]

A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
Xanthine
Xanthine [drugbank:DB02134]

Maltotetraose
Maltotetraose [drugbank:DB02237]

Clinofibrate is a fibrate drug sold and marketed in Japan.
Clinofibrate
Clinofibrate [drugbank:DB09006]

Tetraphenyl-Arsonium
Tetraphenyl-Arsonium [drugbank:DB04435]

(2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
(2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide [drugbank:DB07737]

A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. [PubChem]
Phenazopyridine
Phenazopyridine [drugbank:DB01438]

(4-fluorophenyl)(pyridin-4-yl)methanone
(4-fluorophenyl)(pyridin-4-yl)methanone [drugbank:DB06917]

2-Deoxy-2-Amino Glucitol-6-Phosphate
2-Deoxy-2-Amino Glucitol-6-Phosphate [drugbank:DB02445]

(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol [drugbank:DB07711]

Gadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for visualizing the CNS and heart. In contrast to conventional extracellular fluid contrast agents, gadobenate dimeglumine is characterized by a weak and transient binding capacity to serum proteins. This binding leads to an increased relaxivity of gadobenate dimeglumine and, consequently, to a considerably increased signal intensity over that of other agents.
Gadobenate Dimeglumine
Gadobenate Dimeglumine [drugbank:DB00743]

Phosphonoacetohydroxamic Acid
Phosphonoacetohydroxamic Acid [drugbank:DB03645]

Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).

Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.

Entecavir
Entecavir [drugbank:DB00442]

A phenothiazine derivative that is used as an antipruritic. [PubChem]
Alimemazine
Alimemazine [drugbank:DB01246]

An semisynthetic aminoglycoside antibiotic. Often used for treatment of multi-resistant bacterial infection such as methicillin-resistant Staphylococcus aureus (MRSA). Amikacin is also nephrotoxic and ototoxic.
Arbekacin
Arbekacin [drugbank:DB06696]

CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE [drugbank:DB08740]

Phosphoric Acid Mono-[3-Fluoro-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahyro-Furan-2-Ylmethyl] Ester
Phosphoric Acid Mono-[3-Fluoro-5-(5-Methyl-2,4-Dioxo-3,4-Dihydro-2h-Pyrimidin-1-Yl)-Tetrahyro-Furan-2-Ylmethyl] Ester [drugbank:DB03195]

ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate [drugbank:DB08691]

A semi-synthetic antibiotic related to penicillin. [PubChem]
Nafcillin
Nafcillin [drugbank:DB00607]

3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID
3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID [drugbank:DB07371]

6-Amino-1-Methylpurine
6-Amino-1-Methylpurine [drugbank:DB03164]

1,3,4,9-Tetrahydro-2-(Hydroxybenzoyl)-9-[(4-Hydroxyphenyl)Methyl]-6-Methoxy-2h-Pyrido[3,4-B]Indole
1,3,4,9-Tetrahydro-2-(Hydroxybenzoyl)-9-[(4-Hydroxyphenyl)Methyl]-6-Methoxy-2h-Pyrido[3,4-B]Indole [drugbank:DB04030]

2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide [drugbank:DB06969]

4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDE
4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDE [drugbank:DB08546]

Etoricoxib is a new COX-2 selective inhibitor. Current therapeutic indications are: treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2). This reduces the generation of prostaglandins (PGs) from arachidonic acid.
Etoricoxib
Etoricoxib [drugbank:DB01628]

(7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine
(7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine [drugbank:DB07021]

Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide
Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide [drugbank:DB03984]

(2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE
(2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE [drugbank:DB07081]

Pamidronic acid (INN) or pamidronate disodium (USAN), marketed as pamidronate disodium pentahydrate under the brand name Aredia, is a bisphosphonate. [Wikipedia]
Pamidronate
Pamidronate [drugbank:DB00282]

N-(3-Cyclopropyl(5,6,7,8,9,10-Hexahydro-2-Oxo-2h-Cycloocta[B]Pyran-3-Yl)Methyl)Phenylbenzensulfonamide
N-(3-Cyclopropyl(5,6,7,8,9,10-Hexahydro-2-Oxo-2h-Cycloocta[B]Pyran-3-Yl)Methyl)Phenylbenzensulfonamide [drugbank:DB02033]

Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).
Tositumomab
Tositumomab [drugbank:DB00081]

A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. [PubChem]
Succinylcholine
Succinylcholine [drugbank:DB00202]

AHA047
AHA047 [drugbank:DB03076]

2-Benzo[1,3]Dioxol-5-Ylmethyl-3-Benzyl-Succinic Acid
2-Benzo[1,3]Dioxol-5-Ylmethyl-3-Benzyl-Succinic Acid [drugbank:DB02450]

1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine [drugbank:DB08699]

A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. [PubChem]
Citric Acid
Citric Acid [drugbank:DB04272]

N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline
N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline [drugbank:DB02855]

3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol
3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol [drugbank:DB02395]

N6-METHYL-(R)-ROSCOVITINE, R-2-[6-(BENZYL-METHYL-AMINO)-9-ISOPROPYL-9H-PURIN-2-YLAMINO]-BUTAN-1-OL
N6-METHYL-(R)-ROSCOVITINE, R-2-[6-(BENZYL-METHYL-AMINO)-9-ISOPROPYL-9H-PURIN-2-YLAMINO]-BUTAN-1-OL [drugbank:DB04776]

SB-559448 is a small-molecule drug that mimics the activity of thrombopoietin (TPO), a protein factor that promotes growth and production of blood platelets. This drug is developed by GlaxoSmithKline and used to treat Thrombocytopenia.Thrombocytopenia (decreased platelet count) is a common side effect of many chemotherapies and can lead to uncontrolled bleeding, thus representing a significant problem in the treatment of cancer patients.
SB-559448 [drugbank:DB05930]

(2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE
(2S)-1-{[5-(1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-[(7AS)-7AH-INDOL-3-YL]PROPAN-2-AMINE [drugbank:DB06977]

Deacetoxycephalosporin-C
Deacetoxycephalosporin-C [drugbank:DB03938]

Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours.

Like other dopamine agonists, rotigotine has been shown to possess antidepressant effects and may be useful in the treatment of depression as well.

Rotigotine was developed by Aderis Pharmaceuticals. In 1998, Aderis licensed worldwide development and commercialization rights for rotigotine to the German pharmaceutical company Schwarz Pharma (today a subsidiary of the Belgian company UCB S.A.). The drug has been approved by the EMEA for use in Europe in 2006 and is today being sold in several European countries. In 2007, the Neupro patch was approved by the Food and Drug Administration (FDA) as the first transdermal treatment of Parkinson's disease in the United States. However, as of 2008, Schwarz Pharma has recalled all Neupro patches in the United States and some in Europe because of problems with the delivery mechanism. Rotigotine has been authorized as a treatment for RLS since August 2008.

Rotigotine
Rotigotine [drugbank:DB05271]

Ovalicin
Ovalicin [drugbank:DB04324]

(3R,5S,7R,12S,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECANOIC ACID
(3R,5S,7R,12S,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECANOIC ACID [drugbank:DB07740]

Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is a precursor of citrulline and arginine.
L-Ornithine
L-Ornithine [drugbank:DB00129]

OSI-7836 is a member of the nucleoside class of cytotoxic drugs of which gemcitabine is the market leader. OSI Pharmaceuticals develops OSI-7836 as a next-generation gemcitabine. The anti-tumor activity of OSI-7836 appeares to be less schedule dependent than gemcitabine. It is also more active than ara-C (another clinically used nucleoside analog) in all nine models and more active than either paclitaxel or cisplatin in the two lung xenograft models tested. This drug shows no unexpected toxicities; those observed appeared to be similar to other nucleoside agents.
OSI-7836
OSI-7836 [drugbank:DB05837]

Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. It may be used to mild to moderate hypertension and in the management of symptomatic benign prostatic hyperplasia (BPH). α1-Receptors mediate contraction and hypertrophic growth of smooth muscle cells. Antagonism of these receptors leads to smooth muscle relaxation in the peripheral vasculature and prostate gland.
Doxazosin
Doxazosin [drugbank:DB00590]

Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new class of agents known as histone deacetylase inhibitors. A recent study suggested that vorinostat also possesses some activity against recurrent glioblastoma multiforme, resulting in a median overall survival of 5.7 months (compared to 4 - 4.4 months in earlier studies). Further brain tumor trials are planned in which vorinostat will be combined with other drugs. [Wikipedia]
Vorinostat
Vorinostat [drugbank:DB02546]

L-Alpha-Glycerophosphorylserine
L-Alpha-Glycerophosphorylserine [drugbank:DB02497]

A semisynthetic ampicillin-derived acylureido penicillin. [PubChem]
Azlocillin
Azlocillin [drugbank:DB01061]

N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide
N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamide [drugbank:DB07048]

An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)
Tris(Hydroxymethyl)Aminomethane
Tris(Hydroxymethyl)Aminomethane [drugbank:DB03754]

HGS-TR2J is a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced solid malignancies. It is developed by Human Genome Sciences, Inc and is under Phase I of clinical trial.
HGS-TR2J
HGS-TR2J [drugbank:DB05895]

PROPYL-1-PHOSPHATE
PROPYL-1-PHOSPHATE [drugbank:DB04755]

CRA_9785
CRA_9785 [drugbank:DB03595]

Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester
Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-Isopropylester [drugbank:DB01737]

Benzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
Benzquinamide
Benzquinamide [drugbank:DB00767]

(4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE
(4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE [drugbank:DB08458]

Zn(Ii)-(20-Oxo-Protoporphyrin Ix)
Zn(Ii)-(20-Oxo-Protoporphyrin Ix) [drugbank:DB02920]

Lambda-Bis(2,2'-Bipyridine)Imidazole Ruthenium (Ii)
Lambda-Bis(2,2'-Bipyridine)Imidazole Ruthenium (Ii) [drugbank:DB03871]

Exenatide, derived from a compound found in the saliva of the Gila monster, a large lizard native to the southwestern US, is a functional analog of Glucagon-Like Peptide-1 (GLP-1), a naturally occuring peptide.
Exenatide
Exenatide [drugbank:DB01276]

2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC ACID MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL ESTER
2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC ACID MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL ESTER [drugbank:DB08261]

Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.
Baclofen
Baclofen [drugbank:DB00181]

{3-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Amino]-2-Methyl-Propyl}-Phosphonic Acid
{3-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Amino]-2-Methyl-Propyl}-Phosphonic Acid [drugbank:DB03433]

4-(1,3-BENZOXAZOL-2-YL)-2,6-DIBROMOPHENOL
4-(1,3-BENZOXAZOL-2-YL)-2,6-DIBROMOPHENOL [drugbank:DB08206]

(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE
(5R)-2-SULFANYL-5-[4-(TRIFLUOROMETHYL)BENZYL]-1,3-THIAZOL-4-ONE [drugbank:DB08574]

WF10 is a chlorite-based, immunomodulating drug is developed by Nuvo Research Inc. Certain preclinical evidence and clinical pilot data suggest that WF10 may be effective in treating certain cancers. The Corporation believes the research to-date demonstrates that WF10 acts on macrophages (a type of white blood cell) by modulating the balance between inflammation and phagocytosis, a state in which the body digests foreign, potentially harmful substances. The Corporation has commenced a Phase II clinical trial in an effort to demonstrate the efficacy of WF10 in combination with Xeloda (capecitabine) in the treatment of pancreatic cancer. The trial is being conducted in Germany at the University of Heidelberg and the National Centre for Tumor Diseases.
WF10
WF10 [drugbank:DB05389]

ATX-201 is one of a family of novel compounds that inhibits microtubule polymerization. It is developed by Kythera Biopharmaceuticals, Inc. for the treatment of actinic keratosis. The company announced the decision to discontinue its ATX-201 clinical program for actinic keratosis. The Company determined that the program was not meeting their expected primary and exploratory objectives.
ATX-201
ATX-201 [drugbank:DB05765]

5-(Aminomethyl)-2-Methylpyrimidin-4-Amine
5-(Aminomethyl)-2-Methylpyrimidin-4-Amine [drugbank:DB03204]

Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist. It is not approved in the United States.
Flupentixol
Flupentixol [drugbank:DB00875]

AL5424
AL5424 [drugbank:DB01964]

Developed by the German pharmaceutical company, Merckle GmbH, together with EuroAlliance partners Alfa Wassermann and Lacer, licofelone (ML3000) is a dual COX/LOX inhibitor and the first member of this new class of analgesic and anti-inflammatory drugs. It is currently under evaluation as a treatment for osteoarthritis (OA), the most common form of arthritis. Although phase III trials have been successfully completed in OA patients no dates for regulatory submission have yet been given.
Licofelone
Licofelone [drugbank:DB04725]

SVV-001 (Seneca Valley Virus) is a novel native picornavirus being developed as a systemically deliverable oncolytic virus for treatment of human cancers with neuroendocrine features. It specifically kills cancer cells with features similar to those found in many small cell lung cancers. SVV-001 has also demonstrated cancer-killing specificity 10,000 times higher than that of traditional chemotherapeutics with no overt toxicity at doses one million times higher than effective doses in mice. It is not pathogenic to normal human cells.
SVV-001
SVV-001 [drugbank:DB06129]

Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zydena. It is not yet approved for use in the U.S., E.U., or Canada.
Udenafil
Udenafil [drugbank:DB06267]

Cefamandole (INN, also known as cephamandole) is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. Cefamandole is no longer available in the United States.
Cefamandole
Cefamandole [drugbank:DB01326]

Methyl beta-galactoside
Methyl beta-galactoside [drugbank:DB04046]

CRx-119 is a novel synergistic combination drug candidate discovered using the CombinatoRx combination High Throughput Screening (cHTS(TM)) technology with potential therapeutic use in a broad range of immuno-inflammatory conditions. CRx-119 is a combination of a low dose of the steroid prednisolone, 3mg, and amoxapine.
CRx-119
CRx-119 [drugbank:DB05688]

BMS068645 is a selective A2a adenosine receptor agonist designed for use as a pharmacologic stress agent in cardiac perfusion imaging studies. It is developed by Bristol-Myers Squibb and is in phase II of clinical trials.
BMS068645 [drugbank:DB05009]

Tesmilifene is a novel potentiator of chemotherapy which, when added to doxorubicin, achieved an unexpected and very large survival advantage over doxorubicin alone in a randomized trial in advanced breast cancer.
Tesmilifene
Tesmilifene [drugbank:DB04905]

L-Phenylalaninol
L-Phenylalaninol [drugbank:DB04484]

N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE [drugbank:DB07995]

(5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid
(5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid [drugbank:DB01765]

6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE
6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE [drugbank:DB06861]

GSHNA
GSHNA [drugbank:DB04521]

4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid
4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic Acid [drugbank:DB02466]

4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole
4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole [drugbank:DB03030]

Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate
Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate [drugbank:DB01790]

Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Benzthiazide
Benzthiazide [drugbank:DB00562]

Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome (FCAS) and Muckle-Wells Syndrome (MWS), in adults and children greater than 12 years old.
Rilonacept
Rilonacept [drugbank:DB06372]

BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE
BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE [drugbank:DB07579]

3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester
3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester [drugbank:DB01959]

Acetoacetyl-Coenzyme A
Acetoacetyl-Coenzyme A [drugbank:DB03059]

The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. [PubChem]
Mestranol
Mestranol [drugbank:DB01357]

Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. [PubChem]
Adenosine monophosphate
Adenosine monophosphate [drugbank:DB00131]

Coa-S-Trimethylene-Acetyl-Tryptamine
Coa-S-Trimethylene-Acetyl-Tryptamine [drugbank:DB01777]

rhGAD65 (recombinant human glutamic acid decarboxylase) is a vaccine being developed to treat insulin dependent type 1 diabetes.
rhGAD65
rhGAD65 [drugbank:DB04963]

4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide
4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-Benzamide [drugbank:DB04549]

ORG-34517 is currently under investigation by Organon for the treatment of depression. It has potential to treat a number of diseases such as Cushingâs disease, hypertension, diabetes, glaucoma etc, in which the activity of metabolites corticosterone and cortisol is high.
ORG-34517 [drugbank:DB05423]

Neramexane is a low-to-moderate affinity uncompetitive NMDA receptor antagonist.
Neramexane
Neramexane [drugbank:DB04926]

N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide
N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide [drugbank:DB07536]

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)
Oxamniquine
Oxamniquine [drugbank:DB01096]

2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL
2,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOL [drugbank:DB04792]

L-Xylitol 5-Phosphate
L-Xylitol 5-Phosphate [drugbank:DB02630]

Human erythropoietin (recombinant), produced by CHO cells.
Epoetin alfa
Epoetin alfa [drugbank:DB00016]

N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE
N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE [drugbank:DB07318]

8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM
8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM [drugbank:DB08096]

Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Sodium bicarbonate
Sodium bicarbonate [drugbank:DB01390]

1-3 Sugar Ring of Pentamannosyl 6-Phosphate
1-3 Sugar Ring of Pentamannosyl 6-Phosphate [drugbank:DB02755]

The pipecolinate derivative biricodar (VX-710) is a clinically applicable modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1).
Biricodar dicitrate
Biricodar dicitrate [drugbank:DB04851]

AG-702 is a recombinant human heat shock protein also known as stress protein. It is also known as HSPs, which are a group of proteins that are induced when a cell undergoes various types of environmental stresses like heat, cold and oxygen deprivation. HSPs are present in all cells in all life forms from bacteria to mammals, and their structure and function are similar across these diverse life forms. This drug is developed by antigenics for the treatment of genital herpes infection and is under phase I of clinical trial.
AG-702
AG-702 [drugbank:DB05836]

Dextropropoxyphene is an analgesic in the opioid category, patented (1955) and manufactured by Eli Lilly and Company. It is intended to treat mild pain and also has antitussive and local anaesthetic effects. The drug has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias. An estimated 10 million patients have used these products.

The drug is often referred to as the general form, "propoxyphene", however only the dextro-isomer (dextropropoxyphene) has any analgesic effect. The levo-isomer appears to exhibit a very limited antitussive effect.

Dextropropoxyphene
Dextropropoxyphene [drugbank:DB00647]

N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide [drugbank:DB07183]

Alpha,Alpha,Alpha-Trifluoro-P-Cresol
Alpha,Alpha,Alpha-Trifluoro-P-Cresol [drugbank:DB03610]

SD146
SD146 [drugbank:DB02729]

XL228 is a novel anticancer compound designed to inhibit the insulin-like growth factor type-1 receptor (IGF1R), Src and Abl tyrosine kinases â targets that play crucial roles in cancer cell proliferation, survival and metastasis.
XL228
XL228 [drugbank:DB05184]

A derivative of 7-aminocephalosporanic acid.
Cefacetrile
Cefacetrile [drugbank:DB01414]

5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine
5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine [drugbank:DB07065]

Fludarabine (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. [Wikipedia]
Fludarabine
Fludarabine [drugbank:DB01073]

S-{2-[(2-chloro-4-sulfamoylphenyl)amino]-2-oxoethyl} 6-methyl-3,4-dihydroquinoline-1(2H)-carbothioate
S-{2-[(2-chloro-4-sulfamoylphenyl)amino]-2-oxoethyl} 6-methyl-3,4-dihydroquinoline-1(2H)-carbothioate [drugbank:DB08494]

6-CHLORO-4-(CYCLOHEXYLOXY)-3-ISOPROPYLQUINOLIN-2(1H)-ONE
6-CHLORO-4-(CYCLOHEXYLOXY)-3-ISOPROPYLQUINOLIN-2(1H)-ONE [drugbank:DB07871]

Netilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. [PubChem] Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site. The bactericidal effect of netilmiicin is not fully understood.
Netilmicin
Netilmicin [drugbank:DB00955]

N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE
N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE [drugbank:DB07662]

A bacteriostatic or bactericidal agent depending on the concentration and susceptibility of the infecting organism. Nitrofurantoin is active against some gram positive organisms such as S. aureus, S. epidermidis, S. saprophyticus, Enterococcus faecalis, S. agalactiae, group D streptococci, viridians streptococci and Corynebacterium. Its spectrum of activity against gram negative organisms includes E. coli, Enterobacter, Neisseria, Salmonella and Shigella. It may be used as an alternative to trimethoprim/sulfamethoxazole for treating urinary tract infections though it may be less effective at eradicating vaginal bacteria. May also be used in females as prophylaxis against recurrent cystitis related to coitus. Nitrofurantoin is highly stable to the development of bacterial resistance, a property thought to be due to its multiplicity of mechanisms of action.
Nitrofurantoin
Nitrofurantoin [drugbank:DB00698]

R1626 is one of a new class of hepatitis C therapies called polymerase inhibitors. It achieves significant reductions in viral load in chronic hepatitis C patients infected with the difficult to treat genotype 1 virus. R1626 is very effective in inhibiting viral replication
R1626 [drugbank:DB05060]

NTx-265 is a combination of two currently marketed large molecules designed to stimulate the growth and differentiation of neural stem cells in adults who have suffered a stroke â the second leading cause of death worldwide. In May 2006, biotechnology company Stem Cell Therapeutics started a Phase IIa study of NTx-265. It is also investigating use of the compound for neurodegenerative disorders, such as Huntingtonâs disease and Alzheimerâs disease.
NTx-265
NTx-265 [drugbank:DB05649]

(Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide
(Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide [drugbank:DB03690]

3-Fluoro-2-Methyl-Aniline
3-Fluoro-2-Methyl-Aniline [drugbank:DB01986]

Dipicolinic Acid
Dipicolinic Acid [drugbank:DB04267]

Ramoplanin is a novel glycolipodepsipeptide antibiotic under development for the treatment of CDAD.
Ramoplanin
Ramoplanin [drugbank:DB04952]

An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity. [PubChem]
1-Deoxynojirimycin
1-Deoxynojirimycin [drugbank:DB03206]

Threonine-Aspartic Ester
Threonine-Aspartic Ester [drugbank:DB01817]

Indacaterol is a novel, ultra-long-acting, rapid onset Î²(2)-adrenoceptor agonist developed for Novartis for the once-daily management of asthma and chronic obstructive pulmonary disease. It was approved by the European Medicines Agency (EMA) under the trade name Onbrez on November 30, 2009, and by the United States Food and Drug Administration (FDA), under the trade name Arcapta Neohaler, on July 1, 2011. Indacaterol is provided as its maleate salt form. Indacaterol is also a chiral molecule but only the pure R-enantiomer is dispensed.
Indacaterol
Indacaterol [drugbank:DB05039]

Levetiracetam is an anticonvulsant medication used to treat epilepsy. Levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. Levetiracetam binds to the synaptic vesicle protein SV2A, which is thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of levetiracetam binding to synaptic vesicle protein SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice.
Levetiracetam
Levetiracetam [drugbank:DB01202]

N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE
N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE [drugbank:DB07991]

Bromopurine
Bromopurine [drugbank:DB02168]

A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids. [PubChem]
2-Aminoethanesulfonic Acid
2-Aminoethanesulfonic Acid [drugbank:DB01956]

ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE
ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE [drugbank:DB07884]

4-Methoxyamphetamine
4-Methoxyamphetamine [drugbank:DB01472]

I-Coeleneterazine
I-Coeleneterazine [drugbank:DB04146]

7,8,10-TRIMETHYLBENZO[G]PTERIDINE-2,4(3H,10H)-DIONE
7,8,10-TRIMETHYLBENZO[G]PTERIDINE-2,4(3H,10H)-DIONE [drugbank:DB04726]

A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. [PubChem]
Quercetin
Quercetin [drugbank:DB04216]

Zanapezil (TAK-147) is a selective acetylcholine (ACh) esterase inhibitor under investigation as a drug for Alzheimer's disease (AD) treatment.
Zanapezil
Zanapezil [drugbank:DB04859]

One of the components of virginiamycin, a cyclic polypeptide antibiotic complex from streptomyces virginiae, s. Loidensis, s. Mitakaensis, s. Pristina-spiralis, s. Ostreogriseus, and others. It is used to treat infections with gram-positive organisms and as a growth promoter in cattle, swine, and poultry.
Virginiamycin factor S1
Virginiamycin factor S1 [drugbank:DB04805]

N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE
N-[(1S)-1-(AMINOCARBONYL)-4-(ETHANIMIDOYLAMINO)BUTYL]BENZAMIDE [drugbank:DB07449]

XL820 is a novel small molecule anticancer compound that potently inhibits receptor tyrosine kinases (RTKs) implicated in tumor proliferation and vascularization. XL820 inhibits the VEGF receptor, KIT and the PDGF receptor, which are clinically validated targets implicated in a variety of human cancers. XL820 exhibits dose-dependent growth inhibition in models of breast carcinoma, gliomas and leukemia.
XL820
XL820 [drugbank:DB05146]

MAP-0004 is a proprietary orally inhaled version of dihydroergotamine, or DHE, intended to treat migraine. Study showed that MAP-0004 provided pain relief as early as within ten minutes of dosing, and that this relief was sustained through at least 24 hours. The study also demonstrated efficacy trends in treating nausea, photophobia and phonophobia. Based on these results, as well as independent research that concludes that patients prefer migraine therapies providing fast onset, pain relief, sustained pain relief and safety, the company believes that MAP-0004 has the potential to be a first-line therapy for migraine patients.
MAP-0004
MAP-0004 [drugbank:DB05743]

A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases. [PubChem]
Ethanolamine
Ethanolamine [drugbank:DB03994]

ATG003, a novel anti-angiogenic drug candidate and a formulation of mecamylamine, is currently in clinical development for neovascular age-related macular degeneration.
ATG003
ATG003 [drugbank:DB05069]

LY2140023 is an investigational drug from Lilly, which is being developed as a new treatment option for schizophrenia. LY2140023 is an oral "prodrug," meaning it is devoid of intrinsic biological activity and, once administered, is metabolized to provide the active mGlu2/3 receptor agonist called LY404039. Most currently approved antipsychotic medications work by affecting the neurotransmitters dopamine or serotonin. For LY2140023, the active substance, LY404039, is thought to work by reducing the presynaptic release of another neurotransmitter, glutamate, in brain regions where mGlu2/3 receptors are expressed. Further studies are planned or are ongoing to learn more about the safety and effectiveness, including determining an optimal therapeutic dose for LY2140023.
LY2140023 [drugbank:DB05096]

An immunosuppressive antimetabolite pro-drug. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is converted into 6-mercaptopurine in the body where it blocks purine metabolism and DNA synthesis.
Azathioprine
Azathioprine [drugbank:DB00993]

A dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing. (Grant & Hackh's Chemical Dictionary, 5th ed)
Maltose
Maltose [drugbank:DB03323]

A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. [PubChem]
Biperiden
Biperiden [drugbank:DB00810]

(2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE
(2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE [drugbank:DB07482]

A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them. [PubChem]
Succimer
Succimer [drugbank:DB00566]

N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide
N-(4-chlorobenzyl)-N-methylbenzene-1,4-disulfonamide [drugbank:DB07115]

2-AMINO-4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
2-AMINO-4-HYDROXYPYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER [drugbank:DB06906]

Mycobacterial Cell Wall-DNA Complex (MCC) is formulated from Mycobacterium phlei, a non-pathogenic strain of mycobacteria. MCC has been shown to have immune stimulatory and apoptosis (programmed cell death) activity against cancer cells. The product is a sterile biological composition in a sub-micron suspension. It is produced at the Bioniche manufacturing facility in Pointe-Claire, Quebec.
MCC
MCC [drugbank:DB05282]

3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID [drugbank:DB07298]

Cyclohexyl-pentyl-maltoside
Cyclohexyl-pentyl-maltoside [drugbank:DB04664]

5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine [drugbank:DB08008]

Chlorophyll A
Chlorophyll A [drugbank:DB02133]

N-[1-(4-Bromophenyl)Ethyl]-5-Fluoro Salicylamide
N-[1-(4-Bromophenyl)Ethyl]-5-Fluoro Salicylamide [drugbank:DB02880]

[Methyltelluro]Acetate
[Methyltelluro]Acetate [drugbank:DB01918]

MBP8298 is a synthetic peptide that consists of 17 amino acids linked in a sequence identical to that of a portion of human myelin basic protein (MBP). MBP8298 has been developed for the treatment of multiple sclerosis (MS). Developed at the University of Alberta, MBP8298 is being investigated by BioMS Medical Corp.
MBP8298
MBP8298 [drugbank:DB04921]

A reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols. [PubChem]
1,4-Dithiothreitol
1,4-Dithiothreitol [drugbank:DB04447]

Erdosteine is a mucolytic. Erdosteine is a thiol derivative developed for the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis. Erdosteine contains 2 blocked sulfhydryl groups which are released following first-pass metabolism. The 3 active metabolites exhibit mucolytic and free radical scavenging activity. Erdosteine modulates mucus production and viscosity and increases mucociliary transport, thereby improving expectoration. It also exhibits inhibitory activity against the effects of free radicals produced by cigarette smoke. Clinical studies in patients with chronic obstructive lung disease have demonstrated the efficacy and tolerability of erdosteine. Erdosteine 300mg twice daily reduced cough (both frequency and severity) and sputum viscosity more quickly and more effectively than placebo and reduced the adhesivity of sputum more effectively than ambroxol 30mg twice daily. Co-administration of erdosteine and amoxicillin in patients with acute infective exacerbation of chronic bronchitis resulted in higher concentrations of the antibiotic in the sputum, leading to earlier and more pronounced amelioration of clinical symptoms compared with placebo. Erdosteine is associated with a low incidence of adverse events, most of which are gastrointestinal and generally mild.
Erdosteine
Erdosteine [drugbank:DB05057]

6-(Adenosine Tetraphosphate-Methyl)-7,8-Dihydropterin
6-(Adenosine Tetraphosphate-Methyl)-7,8-Dihydropterin [drugbank:DB04158]

1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole [drugbank:DB03477]

2'-deoxyuridylic acid
2'-deoxyuridylic acid [drugbank:DB03800]

An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)
Isocarboxazid
Isocarboxazid [drugbank:DB01247]

Hydroxyaminovaline
Hydroxyaminovaline [drugbank:DB02697]

2-Ribofuranosyl-3-Iodo-2,3-Dihydro-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
2-Ribofuranosyl-3-Iodo-2,3-Dihydro-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine [drugbank:DB02416]

CAT-213 is a fully human anti-eotaxin monoclonal antibody with potential in the treatment of allergic disorders, has moved into pre-clinical development. It is developed by MedImmune for the treatment of Allergic Rhinitis.
CAT-213
CAT-213 [drugbank:DB05429]

5-(7-(5-HYDRO-4-METHYL-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE
5-(7-(5-HYDRO-4-METHYL-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE [drugbank:DB08727]

(3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid
(3R)-3-ethyl-N-[(4-methylphenyl)sulfonyl]-L-aspartic acid [drugbank:DB06951]

Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Almotriptan does not prevent migraine attacks.
Almotriptan
Almotriptan [drugbank:DB00918]

Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Sargramostim
Sargramostim [drugbank:DB00020]

4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE
4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE [drugbank:DB06852]

(6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
(6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one [drugbank:DB07874]

Bis(Adenosine)-5'-Pentaphosphate
Bis(Adenosine)-5'-Pentaphosphate [drugbank:DB01717]

Synthetic 9 residue cyclic peptide. The hormone is prepared synthetically to avoid possible contamination with vasopressin (ADH) and other small polypeptides with biologic activity.
Oxytocin
Oxytocin [drugbank:DB00107]

Voglibose (INN and USAN) is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix. [Wikipedia]
Voglibose
Voglibose [drugbank:DB04878]

1-Amino-6-Cyclohex-3-Enylmethyloxypurine
1-Amino-6-Cyclohex-3-Enylmethyloxypurine [drugbank:DB02603]

FR236913 [drugbank:DB02830]

The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or prostaglandin F2 alpha tromethamine.
Dinoprost Tromethamine
Dinoprost Tromethamine [drugbank:DB01160]

(3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
(3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one [drugbank:DB07468]

Mercaptomethyl Phosphonate
Mercaptomethyl Phosphonate [drugbank:DB03498]

5-{[Ethyl(Methyl)Amino]Methyl}-2-Methyl-5,6-Dihydropyrimidin-4-Amine
5-{[Ethyl(Methyl)Amino]Methyl}-2-Methyl-5,6-Dihydropyrimidin-4-Amine [drugbank:DB03653]

IMIDAZO[2,1-A]ISOQUINOLINE-2-CARBOHYDRAZIDE
IMIDAZO[2,1-A]ISOQUINOLINE-2-CARBOHYDRAZIDE [drugbank:DB08758]

Difluoromethionine
Difluoromethionine [drugbank:DB03816]

Perchlorate Ion
Perchlorate Ion [drugbank:DB03138]

SP-01A is an antiviral adjuvant indicated in the treatment of HIV-infected individuals. In Phase II clinical trials, SP-01A proved itself to be highly effective in significantly reducing viral load and improving quality of life without compromising the health or safety of HIV-infected patients.
SP-01A
SP-01A [drugbank:DB05342]

Delta-Bis(2,2'-Bipyridine)-(5-Methyl-2-2'-Bipyridine)-C9-Adamantane Ruthenium (Ii)
Delta-Bis(2,2'-Bipyridine)-(5-Methyl-2-2'-Bipyridine)-C9-Adamantane Ruthenium (Ii) [drugbank:DB03875]

5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID
5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID [drugbank:DB07309]

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
Polymyxin B Sulfate
Polymyxin B Sulfate [drugbank:DB00781]

Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid
Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid [drugbank:DB03849]

N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide
N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide [drugbank:DB07879]

D-Mannose 1-Phosphate
D-Mannose 1-Phosphate [drugbank:DB02867]

FavId, is an active immunotherapy that is based upon unique genetic information extracted from a patient's tumor.
FavId
FavId [drugbank:DB05249]

BVDU-MP
BVDU-MP [drugbank:DB04438]

4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE
4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE [drugbank:DB07687]

A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. [PubChem]
Danazol
Danazol [drugbank:DB01406]

A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. [PubChem]
Cefazolin
Cefazolin [drugbank:DB01327]

2'-deoxyuridine 5'-alpha,beta-imido-diphosphate
2'-deoxyuridine 5'-alpha,beta-imido-diphosphate [drugbank:DB03641]

A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Ethionamide
Ethionamide [drugbank:DB00609]

3-Methylphenylalanine
3-Methylphenylalanine [drugbank:DB02685]

4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN [drugbank:DB08480]

MLN-977 is a small molecule compound that inhibits the production of leukotrienes, especially 5-lipoxygenase. It is developed by PharmaEngine to treat asthma and chronic obstructive pulmonary disease.
MLN-977
MLN-977 [drugbank:DB05431]

C-1027 Aromatized Chromophore
C-1027 Aromatized Chromophore [drugbank:DB03933]

Dipipanone
Dipipanone [drugbank:DB01491]

2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide
2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide [drugbank:DB02049]

Chymostatin
Chymostatin [drugbank:DB01683]

N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE
N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE [drugbank:DB08677]

Motexafin gadolinium is studied in the treatment of cancer by Pharmacyclics. It may make tumor cells more sensitive to radiation therapy, improve tumor images using magnetic resonance imaging (MRI), and kill cancer cells. It belongs to the family of drugs called metalloporphyrin complexes. Also called gadolinium texaphyrin.
motexafin gadolinium
motexafin gadolinium [drugbank:DB05428]

1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM
1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUM [drugbank:DB04763]

9-benzyl-2,3,4,9-tetrahydro-1H-carbazole-8-carboxylic acid
9-benzyl-2,3,4,9-tetrahydro-1H-carbazole-8-carboxylic acid [drugbank:DB07283]

One of the angiotensin-converting enzyme inhibitors (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. [PubChem]
Cilazapril
Cilazapril [drugbank:DB01340]

Kava
Kava [drugbank:DB01322]

The D-isomer of aspartic acid. [PubChem]
D-Aspartic Acid
D-Aspartic Acid [drugbank:DB02655]

2-(ACETYL-HYDROXY-AMINO)-4-METHYL-PENTANOIC ACID METHYL ESTER
2-(ACETYL-HYDROXY-AMINO)-4-METHYL-PENTANOIC ACID METHYL ESTER [drugbank:DB07989]

Cefdinir (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December of 1997.
Cefdinir
Cefdinir [drugbank:DB00535]

A phenothiazine used as an antipsychotic agent and as an antiemetic. [PubChem]
Triflupromazine
Triflupromazine [drugbank:DB00508]

N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide
N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide [drugbank:DB04234]

4-[Hydroxy-[Methyl-Phosphinoyl]]-3-Oxo-Butanoic Acid
4-[Hydroxy-[Methyl-Phosphinoyl]]-3-Oxo-Butanoic Acid [drugbank:DB01832]

3-Methyladenine
3-Methyladenine [drugbank:DB04104]

4-(2,5-Dichloro-Thiophen-3-Yl)-Pyrimidin-2-Ylamine
4-(2,5-Dichloro-Thiophen-3-Yl)-Pyrimidin-2-Ylamine [drugbank:DB03019]

1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose
1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose [drugbank:DB03657]

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
Nimesulide
Nimesulide [drugbank:DB04743]

Ranolazine is an antianginal medication. On January 31, 2006, ranolazine was approved for use in the United States by the FDA for the treatment of chronic angina. [Wikipedia]
Ranolazine
Ranolazine [drugbank:DB00243]

TAK-428 is a drug for treating diabetic neuropathy. It is based on the novel concept that peripheral nervous tissue that was damaged by diabetes can be repaired and regenerated by stimulating an increase in neurotrophic factors.
TAK-428
TAK-428 [drugbank:DB05499]

18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE [drugbank:DB07311]

D-Myo-Inositol-1,4-Bisphosphate
D-Myo-Inositol-1,4-Bisphosphate [drugbank:DB03158]

5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide
5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide [drugbank:DB08656]

SP4160
SP4160 [drugbank:DB02555]

4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE
4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE [drugbank:DB08490]

A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)
Dapsone
Dapsone [drugbank:DB00250]

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. [PubChem]
Piroxicam
Piroxicam [drugbank:DB00554]

Phosphoribosyl Atp
Phosphoribosyl Atp [drugbank:DB01661]

A phenothiazine antipsychotic used principally in the treatment of nausea; vomiting; and vertigo. It is more likely than chlorpromazine to cause extrapyramidal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Prochlorperazine
Prochlorperazine [drugbank:DB00433]

N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine
N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine [drugbank:DB08130]

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE
1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE [drugbank:DB07996]

N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE
N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE [drugbank:DB07556]

Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse.
Ramelteon
Ramelteon [drugbank:DB00980]

Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication. Experimental studies are still being investigated to determine all of the physiological effects and mechanisms of action of guvacine. Currently it has been determined that guvacine is a specific GABA reuptake inhibitor with no significant affinity at GABA receptors.
Guvacine
Guvacine [drugbank:DB08848]

D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide
D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide [drugbank:DB06919]

Thiodigalactoside
Thiodigalactoside [drugbank:DB04396]

6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID
6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID [drugbank:DB07714]

Fumarate
Fumarate [drugbank:DB01677]

4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID
4-{3-CHLORO-4-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-PHENOXY}-BUTYRIC ACID [drugbank:DB04643]

(R)-tacrine(10)-hupyridone
(R)-tacrine(10)-hupyridone [drugbank:DB04614]

4-(Carboxyvin-2-Yl)Phenylboronic Acid
4-(Carboxyvin-2-Yl)Phenylboronic Acid [drugbank:DB02503]

5-Amino-5-Deoxy-Cellobiono-1,5-Lactam
5-Amino-5-Deoxy-Cellobiono-1,5-Lactam [drugbank:DB04096]

ANISOMYCIN
ANISOMYCIN [drugbank:DB07374]

(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin
(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin [drugbank:DB02692]

Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
Benazepril
Benazepril [drugbank:DB00542]

Butyramide
Butyramide [drugbank:DB02121]

Glutamyl Group
Glutamyl Group [drugbank:DB03774]

diethyl [(1R)-1,5-diaminopentyl]boronate
diethyl [(1R)-1,5-diaminopentyl]boronate [drugbank:DB06840]

Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
Zonisamide
Zonisamide [drugbank:DB00909]

Coproporphyrin Iii
Coproporphyrin Iii [drugbank:DB04461]

2-Ethoxyethanol
2-Ethoxyethanol [drugbank:DB02249]

(1s,3s,4s)-1,3,4-Triphospho-Myo-Inositol
(1s,3s,4s)-1,3,4-Triphospho-Myo-Inositol [drugbank:DB01729]

(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid
(2E)-3-(3-hydroxy-4-methoxyphenyl)prop-2-enoic acid [drugbank:DB07109]

Epirizole is a nonsteroidal anti-inflammatory drug (NSAID).
Epirizole
Epirizole [drugbank:DB08991]

N-Acetyl-P-Nitrophenylserinol
N-Acetyl-P-Nitrophenylserinol [drugbank:DB02608]

XOMA 052 is a potent anti-inflammatory monoclonal antibody targeting IL-1b and is being developed as a modulator of cytokine imbalance in IL-1 mediated disease states. It has a very high binding affinity of 300fM and blocks the activation of IL-1 receptors. XOMA 052 is also an IgG2 isotype, which reduces the possibility of antibody dependent cellular cytotoxicity. Blocking IL-1Î² with XOMA 052 offers a novel approach to the treatment and control of Type 2 diabetes.
XOMA 052
XOMA 052 [drugbank:DB06062]

Bolasterone
Bolasterone [drugbank:DB01471]

A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. [PubChem]
Glucose-Uridine-C1,5'-Diphosphate
Glucose-Uridine-C1,5'-Diphosphate [drugbank:DB01861]

IC41 is a therapeutic peptide vaccine. It is being devloped by Intercell AG for the treatment of hepatitis C. The vaccine consists of five synthetic peptides (IPEP83, 84, 87, 89,1426) harboring HCV CD4 and CD8 T-cell epitopes and the synthetic adjuvant poly-L-arginine.
IC41
IC41 [drugbank:DB05776]

7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE
7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE [drugbank:DB07173]

Alfimeprase is a recombinant analog of fibrolase. Fibrolase is a zinc-containing metalloproteinase isolated from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix). It is a small protein that contains 203 residues (Randolph et al. 1992). Alfimeprase is being developed by Nuvelo.
Alfimeprase
Alfimeprase [drugbank:DB04919]

5-AMINO-2-{4-[(4-AMINOPHENYL)SULFANYL]PHENYL}-1H-ISOINDOLE-1,3(2H)-DIONE
5-AMINO-2-{4-[(4-AMINOPHENYL)SULFANYL]PHENYL}-1H-ISOINDOLE-1,3(2H)-DIONE [drugbank:DB07971]

A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. [PubChem]
Norfloxacin
Norfloxacin [drugbank:DB01059]

7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline
7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline [drugbank:DB03824]

Highly purified sheep hyaluronidase for administration by injection into the vitreous of the eye.
Hyaluronidase
Hyaluronidase [drugbank:DB00070]

Risperidone, a benzisoxazole derivative, is an atypical antipsychotic drug with high affinity for 5-hydrotryptamine (5-HT) and dopamine D2 receptors. It is used primarily in the management of schizophrenia, inappropriate behavior in severe dementia and manic episodes associated with bipolar I disorder. Risperidone is effective for treating the positive and negative symptoms of schizophrenia owing to its affinity for its âlooseâ binding affinity for dopamine D2 receptors and additional 5-HT antagonism compared to first generation antipsychotics, which are strong, non-specific dopamine D2 receptor antagonists.
Risperidone
Risperidone [drugbank:DB00734]

Bentoquatam is a topical medication intended to act as a shield against exposure to the irritating substance urushiol, found in plants such as poison ivy or poison oak. Bentoquatam contains bentonite, a clay, and is only effective as long as the film is visible on the skin.
Bentoquatam
Bentoquatam [drugbank:DB00516]

THIO-ATPA
THIO-ATPA [drugbank:DB04798]

9-Beta-D-Xylofuranosyl-Adenine
9-Beta-D-Xylofuranosyl-Adenine [drugbank:DB03528]

SR11254 [drugbank:DB02258]

1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester
1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester [drugbank:DB03183]

{1-[(3-Hydroxy-Methyl-5-Phosphonooxy-Methyl-Pyridin-4-Ylmethyl)-Amino]-Ethyl}-Phosphonic Acid
{1-[(3-Hydroxy-Methyl-5-Phosphonooxy-Methyl-Pyridin-4-Ylmethyl)-Amino]-Ethyl}-Phosphonic Acid [drugbank:DB03327]

(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
(5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE [drugbank:DB07763]

(1r,4s)-2-Azabornane
(1r,4s)-2-Azabornane [drugbank:DB02409]

Benzylsulfinic Acid
Benzylsulfinic Acid [drugbank:DB03297]

METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE
METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE [drugbank:DB07223]

Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium Sm 153 lexidronam is used to help relieve the bone pain that may occur with certain kinds of cancer. The radioactive samarium is taken up in the bone cancer area and gives off radiation that helps provide relief of pain.
Samarium (153sm) lexidronam
Samarium (153sm) lexidronam [drugbank:DB05273]

Nissan Chemical and Taisho have been jointly developing NM-702, a drug for the treatment of arteriosclerosis obliterans.

M-702 is an orally active inhibitor of phosphodiesterase and thromboxane synthetase. In Japan, Phase 2 studies are being conducted for intermittent claudication caused by arteriosclerosis obliterans, intermittent claudication caused by spinal canal stenosis, and asthma. In the USA, a Phase 2 study for intermittent claudication caused by arteriosclerosis obliterans has been successfully completed. Intermittent claudication is a major symptom of arteriosclerosis obliterans. It is caused by insufficient oxygen supply to exercising muscles in the lower extremities due to decreased blood flow as a result of sclerosis of peripheral arteries. It is estimated that about 6 million people suffer from intermittent claudication in the USA, with only 10 percent of these people currently receiving treatment. Patients with claudication experience significant disability, owing to their exercise limitation. Therapeutic options to improve exercise performance in these patients are limited

NM-702
NM-702 [drugbank:DB05505]

4-Deoxy-D-Glucuronic Acid
4-Deoxy-D-Glucuronic Acid [drugbank:DB04548]

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.
Lisinopril
Lisinopril [drugbank:DB00722]

Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes [Wikipedia]. Two pharmacological characteristics that sets linagliptin apart from other DPP-4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011.
Linagliptin
Linagliptin [drugbank:DB08882]

Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate like properties.
Zopiclone
Zopiclone [drugbank:DB01198]

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. [PubChem]
Epirubicin
Epirubicin [drugbank:DB00445]

A synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-positive bacteria. [PubChem]
Pefloxacin
Pefloxacin [drugbank:DB00487]

(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one
(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one [drugbank:DB07148]

3-Phosphoglycerol
3-Phosphoglycerol [drugbank:DB02515]

R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID
R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID [drugbank:DB07031]

[4-R-(4-ALPHA,6-BETA,7-BETA]-HEXAHYDRO-5,6-DI(HYDROXY)-1,3-DI(ALLYL)-4,7-BISPHENYLMETHYL)-2H-1,3-DIAZEPINONE
[4-R-(4-ALPHA,6-BETA,7-BETA]-HEXAHYDRO-5,6-DI(HYDROXY)-1,3-DI(ALLYL)-4,7-BISPHENYLMETHYL)-2H-1,3-DIAZEPINONE [drugbank:DB06910]

(5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
(5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC [drugbank:DB07654]

9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE [drugbank:DB07006]

REP8839 is a novel methionyl-tRNA synthetase (MetS) inhibitor being developed by Replidyne (GlaxoSmithKline licensed REP8839 to Replidyne in June of 2003).
REP8839
REP8839 [drugbank:DB05224]

(3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
(3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one [drugbank:DB07470]

{4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID
{4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID [drugbank:DB07127]

DIETHYL PROPANE-1,3-DIYLBISCARBAMATE
DIETHYL PROPANE-1,3-DIYLBISCARBAMATE [drugbank:DB08501]

Ghavamiol
Ghavamiol [drugbank:DB02492]

6-Amino-4-Hydroxymethyl-Cyclohex-4-Ene-1,2,3-Triol
6-Amino-4-Hydroxymethyl-Cyclohex-4-Ene-1,2,3-Triol [drugbank:DB02120]

1,2-Di-1-(3,7,11,15-Tetramethyl-Hexadecane)-Sn-Glycero-3-Phosphate
1,2-Di-1-(3,7,11,15-Tetramethyl-Hexadecane)-Sn-Glycero-3-Phosphate [drugbank:DB03402]

(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE
(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE [drugbank:DB07211]

Nojirimycine Tetrazole
Nojirimycine Tetrazole [drugbank:DB02471]

5-Hydroxymethylene-6-Hydrofolic Acid
5-Hydroxymethylene-6-Hydrofolic Acid [drugbank:DB02800]

N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide
N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide [drugbank:DB02350]

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. [PubChem]
Hydrochlorothiazide
Hydrochlorothiazide [drugbank:DB00999]

Carba-Nicotinamide-Adenine-Dinucleotide
Carba-Nicotinamide-Adenine-Dinucleotide [drugbank:DB02498]

(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid
(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid [drugbank:DB08783]

A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Indinavir
Indinavir [drugbank:DB00224]

6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one
6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one [drugbank:DB08379]

2-[3,5-DICHLORO-4-(2-{2-[2(2-MERCAPTOETHOXY)ETHOXY]ETHOXY}ETHOXY)PHENYLAMINO]BENZOIC ACID
2-[3,5-DICHLORO-4-(2-{2-[2(2-MERCAPTOETHOXY)ETHOXY]ETHOXY}ETHOXY)PHENYLAMINO]BENZOIC ACID [drugbank:DB04756]

A topical glucocorticoid used in the treatment of eczema. [PubChem]
Fluocinonide
Fluocinonide [drugbank:DB01047]

FR233623 [drugbank:DB03220]

Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signaling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate. Besides rheumatoid arthritis, tofacitinib has also been studied in clinical trials for the prevention of organ transplant rejection, and the treatment of psoriasis and ulcerative colitis. Known adverse effects include nausea and headache as well as more serious immunologic and hematological adverse effects. Tofacitinib is marketed under the brand name Xeljanz.
Tofacitinib
Tofacitinib [drugbank:DB08895]

2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine
2-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-Carboxamidine [drugbank:DB02287]

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
Chlorphenamine
Chlorphenamine [drugbank:DB01114]

ZK-806711 [drugbank:DB03373]

2-Ammoniobut-3-Enoate, 2-Amino-3-Butenoate
2-Ammoniobut-3-Enoate, 2-Amino-3-Butenoate [drugbank:DB01804]

2-(3-CARBOXYPROPIONYL)-6-HYDROXY-CYCLOHEXA-2,4-DIENE CARBOXYLIC ACID
2-(3-CARBOXYPROPIONYL)-6-HYDROXY-CYCLOHEXA-2,4-DIENE CARBOXYLIC ACID [drugbank:DB06864]

(E)-3,4-DIHYDROXY-N'-[(2-METHOXYNAPHTHALEN-1-YL)METHYLENE]BENZOHYDRAZIDE
(E)-3,4-DIHYDROXY-N'-[(2-METHOXYNAPHTHALEN-1-YL)METHYLENE]BENZOHYDRAZIDE [drugbank:DB08034]

Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid. [PubChem]
Aspartame
Aspartame [drugbank:DB00168]

(11E)-OCTADEC-11-ENOIC ACID
(11E)-OCTADEC-11-ENOIC ACID [drugbank:DB04801]

A synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase. [PubChem]
Nalidixic Acid
Nalidixic Acid [drugbank:DB00779]

5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE [drugbank:DB07495]

Lactose Sialic Acid
Lactose Sialic Acid [drugbank:DB03296]

(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid
(2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid [drugbank:DB07070]

Integrins are important adhesion molecules that regulate tumor and endothelial cell survival, proliferation and migration. The integrin alpha5beta1 has been shown to play a critical role during angiogenesis. anti-alpha5beta1 integrin antibody inhibits angiogenesis, including vessel formation induced by vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), as well as other pro-angiogenic growth factors.
anti-alpha5Beta1-integrin antibody
anti-alpha5Beta1-integrin antibody [drugbank:DB05870]

(2r)-Amino(4-Hydroxyphenyl)Acetic Acid
(2r)-Amino(4-Hydroxyphenyl)Acetic Acid [drugbank:DB04308]

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
Diethylpropion
Diethylpropion [drugbank:DB00937]

2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL
2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL [drugbank:DB07032]

N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)Benzenaminium
N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)Benzenaminium [drugbank:DB01800]

Reglixane, an isoxazolidine-3,5-dione derivative, is being developed by Pfizer for the treatment of diabetes. It is the first non-thiazolidenedione to enter clinical trials.
Reglixane
Reglixane [drugbank:DB04971]

4-(Hydroxymercury)Benzoic Acid
4-(Hydroxymercury)Benzoic Acid [drugbank:DB01671]

Metocurine iodide is a benzylisoquinolinium competitive nondepolarizing neuromuscular blocking agent. It is used as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy Metocurine iodide has a moderate risk of inducing histamine release and has some ganglion blocking activity. Metocurine iodide can be used most advantageously if muscle twitch response to peripheral nerve stimulation is monitored to assess degree of muscle relaxation. Metocurine Iodide is no longer available on the US market.
Metocurine Iodide
Metocurine Iodide [drugbank:DB00416]

4-Methylthio-Alpha-D-Mannose
4-Methylthio-Alpha-D-Mannose [drugbank:DB02730]

N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [drugbank:DB02558]

Ethinamate is a short-acting sedative-hypnotic medication used to treat insomnia. Regular use leads to tolerance, and it is usually not effective for more than 7 days. Structurally, it does not resemble the barbituates, but it shares many effects with this class of drugs; the depressant effects of ethinamate are, however, generally milder than those of most barbiturates.
Ethinamate
Ethinamate [drugbank:DB01031]

4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE
4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE [drugbank:DB07403]

A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. [PubChem]
Rifabutin
Rifabutin [drugbank:DB00615]

5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine
5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine [drugbank:DB02402]

Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Ketoprofen
Ketoprofen [drugbank:DB01009]

N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE
N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDE [drugbank:DB08301]

Beta-1,4-Galactobioside
Beta-1,4-Galactobioside [drugbank:DB02743]

4'-Phosphopantetheine
4'-Phosphopantetheine [drugbank:DB03912]

R048-8071 [drugbank:DB02016]

A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications. [PubChem]
Trifluoroethanol
Trifluoroethanol [drugbank:DB03226]

Huperzine A, is a naturally occurring sesquiterpene alkaloid found in the extracts of the firmoss Huperzia serrata. The botanical has been used in China for centuries for the treatment of swelling, fever and blood disorders. Recently in clinical trials in China, it has demonstrated neuroprotective effects. It is currently being investigated as a possible treatment for diseases characterized by neurodegeneration â particularly Alzheimerâs disease. [Wikipedia]
Huperzine A
Huperzine A [drugbank:DB04864]

(3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE
(3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE [drugbank:DB07666]

ISA247 is a novel cyclosporine analog. It is an immunosuppressive compound currently being investigated for the treatment of psoriasis and for the prevention of organ rejection in kidney transplant patients. All studies to date suggest that ISA247 is more potent and less toxic than currently available treatments within the drug class of calcineurin inhibitors.
ISA247
ISA247 [drugbank:DB04906]

Dimethylformamide
Dimethylformamide [drugbank:DB01844]

N-Propargyl-1(S)-Aminoindan
N-Propargyl-1(S)-Aminoindan [drugbank:DB03894]

An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal. [PubChem]
Berberine
Berberine [drugbank:DB04115]

2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethanol
2-[2-(2-Hydroxy-Ethoxy)-Ethoxy]-Ethanol [drugbank:DB02327]

Adrenergic beta-agonist used to control premature labor. [PubChem]
Ritodrine
Ritodrine [drugbank:DB00867]

A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Droperidol
Droperidol [drugbank:DB00450]

N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE
N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE [drugbank:DB07123]

Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help. [Wikipedia]
Terlipressin
Terlipressin [drugbank:DB02638]

An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem]
Alitretinoin
Alitretinoin [drugbank:DB00523]

Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.
Dantrolene
Dantrolene [drugbank:DB01219]

O-Acetylserine
O-Acetylserine [drugbank:DB01837]

Human GM-CSF (Granulocyte/Monocyte-Colony Stimulating Factor) is a differentially glycosylated factor produced mainly by activated T cells and macrophages. Endothelial cells and fibroblasts can also produce GM-CSF after exposure to TNF-Î±, IL-1, IL-2 and IFN-Î³. GM-CSF is found associated with extracellular matrix and in membrane-bound formats too. GM-CSF stimulates proliferation, activation and differentiation of macrophages and granulocytes and their progenitors.
recombinant human GM-CSF
recombinant human GM-CSF [drugbank:DB05386]

2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine
2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine [drugbank:DB07942]

Purvalanol A
Purvalanol A [drugbank:DB04751]

(S)-2-[4-(Aminomethyl)-1h-1,2,3-Triazol-1-Yl]-4-Methylpentanoic Acid
(S)-2-[4-(Aminomethyl)-1h-1,2,3-Triazol-1-Yl]-4-Methylpentanoic Acid [drugbank:DB03244]

6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE [drugbank:DB08339]

4-Methyl-5-Hydroxyethylthiazole Phosphate
4-Methyl-5-Hydroxyethylthiazole Phosphate [drugbank:DB03145]

Z-Pro-Prolinal
Z-Pro-Prolinal [drugbank:DB03535]

Beta-D-Fructopyranose
Beta-D-Fructopyranose [drugbank:DB02561]

KD7040 is a topically-delivered inducible nitric oxide synthase (iNOS) inhibitor for the treatment of neuropathic pain. The KD7040 IND was filed in 4Q06, and a Phase Ib clinical trial began 2Q07. It is being developed by Kalypsys.
KD7040
KD7040 [drugbank:DB05214]

cyclic 3',5'-thymidine monophosphate
cyclic 3',5'-thymidine monophosphate [drugbank:DB04672]

4-Bromo-2,5-dimethoxyamphetamine
4-Bromo-2,5-dimethoxyamphetamine [drugbank:DB01484]

Phosphoaspartate
Phosphoaspartate [drugbank:DB01857]

A psychedelic phenyl isopropylamine derivative, commonly called DOM, whose mood-altering effects and mechanism of action may be similar to those of LSD. [PubChem]
4-Methyl-2,5-dimethoxyamphetamine
4-Methyl-2,5-dimethoxyamphetamine [drugbank:DB01528]

4-(ACETYLAMINO)-3-HYDROXY-5-NITROBENZOIC ACID
4-(ACETYLAMINO)-3-HYDROXY-5-NITROBENZOIC ACID [drugbank:DB08570]

A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine. [PubChem]
L-Cystine
L-Cystine [drugbank:DB00138]

Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, it must be kept in tightly-sealed containers. [Wikipedia]
Calcium Chloride
Calcium Chloride [drugbank:DB01164]

An antibiotic derived from penicillin similar to carbenicillin in action.
Ticarcillin
Ticarcillin [drugbank:DB01607]

Adamantanone
Adamantanone [drugbank:DB02125]

ACCLAIM (organic nitrate combined with L-arginine), is an oral proprietary nitrate therapeutic shown to induce coronary vasodilation while overcoming the significant problem of drug tolerance. ACCLAIM treat chronic angina, the chest pain that occurs from inadequate blood flow to the coronary arteries around the heart.
ACCLAIM
ACCLAIM [drugbank:DB05252]

2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine
2,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]Pyrimidine [drugbank:DB02104]

LU-31130 is a rapid acting therapy developed by H. Lundbeck A/S to treat Psychosis, Schizophrenia and Schizoaffective Disorders. It acts at the Dopamine D4 receptors in the cortex and has low affinity for D2 receptors, adrenoceptors, muscarinic and histaminergic receptors. It provides anti-psychotic characteristic and a low incidence of extrapyramidal and cardiovascular side effects.
LU-31130 [drugbank:DB05828]

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool to optimize surgical outcomes.
Bromfenac
Bromfenac [drugbank:DB00963]

N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE
N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE [drugbank:DB06857]

Implitapide is a microsomal triglyceride transfer protein (MTP)-inhibitor.
Implitapide
Implitapide [drugbank:DB04852]

GSK-923295 is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), and the third novel drug candidate to arise from Cytokinetics' broad strategic alliance with GlaxoSmithKline (GSK). GSK-923295 demonstrated a broad spectrum of activity against a range of human tumor xenografts grown in nude mice, including models of colon, breast, ovarian, lung and other tumors. GSK-923295 is the first drug candidate to enter human clinical trials that specifically targets CENP-E and is currently in Phase I human clinical trials being conducted by GSK.
GSK-923295 [drugbank:DB06097]

N-Acetyl Serotonin
N-Acetyl Serotonin [drugbank:DB04275]

FM-VP4, is a novel hydrophilic phytostanol analogue representing a new class in cholesterol-lowering drugs called cholesterol absorption inhibitors. FM-VP4 has been shown to inhibit cholesterol absorption and to lower plasma LDL-cholesterol and total cholesterol in a broad range of animal species. Additional experiments suggest that FM-VP4 can reduce plasma LDL cholesterol levels and triglyceride levels, reduce weight gain and exert a anti-atherosclerosis effect
FM-VP4
FM-VP4 [drugbank:DB05449]

3,8,9,10-Tetrahydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione
3,8,9,10-Tetrahydroxy-7-Hydroxymethyl-6-Oxa-1,3-Diaza-Spiro[4.5]Decane-2,4-Dione [drugbank:DB02447]

A synthetic mineralocorticoid with anti-inflammatory activity. [PubChem]
Fludrocortisone
Fludrocortisone [drugbank:DB00687]

2-(Phosphonooxy)Butanoic Acid
2-(Phosphonooxy)Butanoic Acid [drugbank:DB03248]

The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands, and the brain. It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. [PubChem]
Progesterone
Progesterone [drugbank:DB00396]

S-Methylcysteine
S-Methylcysteine [drugbank:DB02216]

2-(4-hydroxybiphenyl-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione
2-(4-hydroxybiphenyl-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione [drugbank:DB07507]

(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE
(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE [drugbank:DB07462]

Uridine-5'-Diphosphate-Mannose
Uridine-5'-Diphosphate-Mannose [drugbank:DB02421]

5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine
5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine [drugbank:DB02004]

2-{1-[2-(2-Amino-Thiazol-4-Yl)-2-Methoxyimino-Acetylamino]-2-Oxo-Ethyl}-5,5-Dimethyl-Thiazolidine-4-Carboxylic Acid
2-{1-[2-(2-Amino-Thiazol-4-Yl)-2-Methoxyimino-Acetylamino]-2-Oxo-Ethyl}-5,5-Dimethyl-Thiazolidine-4-Carboxylic Acid [drugbank:DB03437]

beta-D-Ribopyranose
beta-D-Ribopyranose [drugbank:DB04286]

Deoxy-Bigchap
Deoxy-Bigchap [drugbank:DB01890]

D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide
D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide [drugbank:DB06996]

The quinoline-3-carboxamide anti-angiogenic agent, tasquinimod, enhances the anti-prostate cancer efficacy of androgen ablation and taxotere without effecting serum PSA directly in human xenografts
TASQ
TASQ [drugbank:DB05861]

Ethyl-Carbamic Acid Methyl Ester
Ethyl-Carbamic Acid Methyl Ester [drugbank:DB03919]

Gpi-1046
Gpi-1046 [drugbank:DB01951]

CRA_11092 [drugbank:DB03555]

3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine
3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine [drugbank:DB08537]

(3R,4S,5S,7R,9E,11R,12R)-12-ETHYL-4-HYDROXY-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE [drugbank:DB07703]

Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
Artemether
Artemether [drugbank:DB06697]

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Cinchocaine
Cinchocaine [drugbank:DB00527]

A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. [PubChem]
Fenoldopam
Fenoldopam [drugbank:DB00800]

(3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE
(3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE [drugbank:DB07796]

A derivative of prednisolone with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than fluocinonide, it is used topically in treatment of psoriasis but may cause marked adrenocortical suppression. [PubChem]
Clobetasol propionate
Clobetasol propionate [drugbank:DB01013]

3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE [drugbank:DB07456]

One of the benzodiazepines that is used in the treatment of anxiety disorders. [PubChem] It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepines.
Bromazepam
Bromazepam [drugbank:DB01558]

Enalapril is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to enalaprilat following oral administration. Enalaprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure.
Enalapril
Enalapril [drugbank:DB00584]

Glycyl-L-Alpha-Amino-Epsilon-Pimelyl-D-Alanyl-D-Alanine
Glycyl-L-Alpha-Amino-Epsilon-Pimelyl-D-Alanyl-D-Alanine [drugbank:DB02578]

Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), exhibited low toxicity and significant anticancer activity in vitro and in vivo. It shows greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than BA in preclinical studies.
Pivaloyloxymethyl butyrate
Pivaloyloxymethyl butyrate [drugbank:DB05103]

6-CHLORO-4-(CYCLOHEXYLOXY)-3-PROPYLQUINOLIN-2(1H)-ONE
6-CHLORO-4-(CYCLOHEXYLOXY)-3-PROPYLQUINOLIN-2(1H)-ONE [drugbank:DB07867]

Boceprevir is a direct acting protease inhibitor for the treatment of hepatitis C. It also has two isomers in which the S isomer is more active than the R-isomer. FDA approved on May 13, 2011.
Boceprevir
Boceprevir [drugbank:DB08873]

(S)-tacrine(10)-hupyridone
(S)-tacrine(10)-hupyridone [drugbank:DB04615]

4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile
4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile [drugbank:DB07511]

2,5-Dimethylpyrimidin-4-Amine
2,5-Dimethylpyrimidin-4-Amine [drugbank:DB02372]

Insulin regular is a 51 residue peptide hormone, composed of two amino acid chains covalently linked by disulfide bonds. The structure is identical to native human insulin. Recombinant insulin is synthesized by recombinant DNA techncology. Inserting the human insulin gene into the Escherichia coli bacteria or Saccharomyces cerevisiae produces insulin for human use.
Insulin Regular
Insulin Regular [drugbank:DB00030]

6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine
6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl)but-1-yn-1-yl]pyrimidine-2,4-diamine [drugbank:DB07153]

(6-METHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL)METHYLPHOSPHINATE
(6-METHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL)METHYLPHOSPHINATE [drugbank:DB07487]

A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. [PubChem]
Tripelennamine
Tripelennamine [drugbank:DB00792]

Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver. [Wikipedia]
Benzoylecgonine
Benzoylecgonine [drugbank:DB01515]

A centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation. [PubChem]
Guanfacine
Guanfacine [drugbank:DB01018]

N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE [drugbank:DB08066]

Olmesartan is an antihypertensive agent, which belongs to the class of medications called angiotensin II receptor blockers. It is indicated for the treatment of high blood pressure and is marketed under the name OlmetecÂ®. The FDA label includes a black-box warning of injury and death to the fetus, so women of child-bearing age need to be warned and take the necessary precautions. Olmesartan is also contraindicated in diabetes mellitus patients taking aliskiren.
Olmesartan
Olmesartan [drugbank:DB00275]

A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. Cyclosporine is produced as a metabolite by the fungus species Cordyceps militaris. (From Martindale, The Extra Pharmacopoeia, 30th ed).
Cyclosporine
Cyclosporine [drugbank:DB00091]

(2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL
(2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL [drugbank:DB07379]

5-(7-(5-HYDRO-4-ETHYL-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE
5-(7-(5-HYDRO-4-ETHYL-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE [drugbank:DB08725]

BIS(HEXAMETHYLENE)TRIAMINE
BIS(HEXAMETHYLENE)TRIAMINE [drugbank:DB04684]

4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose
4,6-Dideoxy-4-{[4,5,6-Trihydroxy-3-(Hydroxymethyl)Cyclohex-2-En-1-Yl]Amino}-Alpha-D-Lyxo-Hexopyranosyl-(1->4)-Alpha-D-Threo-Hexopyranosyl-(1->6)-Alpha-L-Threo-Hexopyranose [drugbank:DB03495]

6-Aza-Ump
6-Aza-Ump [drugbank:DB03718]

8-Azaxanthine
8-Azaxanthine [drugbank:DB01875]

THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE
THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE [drugbank:DB07261]

Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors.
Desflurane
Desflurane [drugbank:DB01189]

TP508 is a non-proteolytic synthetic peptide representing the portion of human thrombin originally identified as the fibroblast high-affinity receptor binding domain.
TP-508
TP-508 [drugbank:DB05309]

5-androstenedione is a prohormone of testosterone. In the United States, the Controlled Substance Act is inclusive to anabolic steroids and their precursors. Thus 5-androstenedione is a controlled substance. The World Anti-Doping Agency also prohibits use of 5-androstenedione in athletes.

5-androstenedione is structurally similar to 4-androstenedione, with the exception of the positioning of a carbon-carbon double bond. 4-Androstenedione is a prohormone which is naturally produced in the body by the adrenal glands and gonads, and acts as precursor to testosterone, as well as estrone and estradiol. [Wikipedia]

5-androstenedione
5-androstenedione [drugbank:DB01456]

Cilansetron is a drug that is a 5HT-3 antagonist currently under trial phase in the EU and US. It is manufactured by Solvay Pharmaceuticals INC. [Wikipedia]
Cilansetron
Cilansetron [drugbank:DB04885]

PHX1149 is a novel orally administered inhibitor of DPP4 for the treatment of type 2 diabetes.
PHX1149
PHX1149 [drugbank:DB05065]

2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE
2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE [drugbank:DB07393]

(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE [drugbank:DB08520]

CEP-1347 is a semi-synthetic compound shown to protect multiple nerve cell types from a variety of insults leading to programmed cell death (apoptosis) which could improve the survival of dopamine neurons prior to and after transplantation.
CEP-1347
CEP-1347 [drugbank:DB05403]

An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
Glucose-6-Phosphate
Glucose-6-Phosphate [drugbank:DB03581]

ORTHONITROPHENYL-BETA-D-FUCOPYRANOSIDE
ORTHONITROPHENYL-BETA-D-FUCOPYRANOSIDE [drugbank:DB08297]

5-PENTYL-2-PHENOXYPHENOL
5-PENTYL-2-PHENOXYPHENOL [drugbank:DB07178]

Phosphoglycolohydroxamic Acid
Phosphoglycolohydroxamic Acid [drugbank:DB03026]

Soraphen A
Soraphen A [drugbank:DB02859]

(2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID
(2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID [drugbank:DB07028]

Galiximab is a chimeric monoclonal antibody which is used as an immunosuppressive drug.
Galiximab
Galiximab [drugbank:DB04901]

Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure.
Candoxatril
Candoxatril [drugbank:DB00616]

Naphthalen-1-Yl-Acetic Acid
Naphthalen-1-Yl-Acetic Acid [drugbank:DB01750]

A potent inhibitor of membrane metalloendopeptidase (enkephalinase). Thiorphan potentiates morphine-induced analgesia and attenuates naloxone-precipitated withdrawal symptoms.
Thiorphan
Thiorphan [drugbank:DB08626]

PSN357 is a glycogen phosphorylase inhibitor (GPI), which is designed to rapidly lower blood glucose levels by preventing glycogen breakdown to glucose in the liver.
PSN357
PSN357 [drugbank:DB05044]

(9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM
(9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM [drugbank:DB04617]

Codeine methylbromide
Codeine methylbromide [drugbank:DB01477]

3-Deoxy-D-Manno-Oct-2-Ulosonic Acid
3-Deoxy-D-Manno-Oct-2-Ulosonic Acid [drugbank:DB03548]

7-carboxy-5-hydroxy-12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
7-carboxy-5-hydroxy-12,13-dihydro-6H-indolo[2,3-a]pyrrolo[3,4-c]carbazole [drugbank:DB07241]

2-Amino-N,3,3-Trimethylbutanamide
2-Amino-N,3,3-Trimethylbutanamide [drugbank:DB01949]

2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE
2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE [drugbank:DB07550]

(2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
(2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide [drugbank:DB08564]

An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. [PubChem]
Midodrine
Midodrine [drugbank:DB00211]

1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine
1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine [drugbank:DB03968]

2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol
2,6-dimethyl-4-[(E)-2-phenylethenyl]phenol [drugbank:DB08100]

Zoledronate (zoledronic acid, marketed by Novartis under the trade names Zometa and Reclast) is a bisphosphonate. Zometa is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases.

An annual dose of Zoledronate may also prevent recurring fractures in patients with a previous hip fracture.

Zoledronate is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the FDA also approved Reclast for the treatment of postmenopausal osteoporosis.

Zoledronate
Zoledronate [drugbank:DB00399]

KOS-1584 is a second-generation epothilone. Epothilones are anticancer agents with a taxane-like mechanism of action that have demonstrated activity in taxane-resistant tumors. KOS-1584 is a second-generation compound with increased potency, favorable tissue distribution, and ease of formulation.
KOS-1584
KOS-1584 [drugbank:DB05903]

The active substance in Epoetin zeta is a recombinant human erythropoietin (rhEPO) of identical primary structure produced in Chinese Hamster Ovary (CHO) cells. The molecular weight of the glycosylated protein is 30.6 kDa according to the Ph. Eur. monograph, 40% of which are carbohydrate structures. The oligosaccharide chains are subject to posttranslational modifications and display heterogeneity to a certain extent. Epoetin zeta is also identical to Epoetin alfa in terms of its amino acid sequence.
Epoetin Zeta
Epoetin Zeta [drugbank:DB08923]

Nicotinamide 8-Bromo-Adenine Dinucleotide Phosphate
Nicotinamide 8-Bromo-Adenine Dinucleotide Phosphate [drugbank:DB03962]

Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone
Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone [drugbank:DB03213]

Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%).
Gliclazide
Gliclazide [drugbank:DB01120]

A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). Neomycin is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.
Neomycin
Neomycin [drugbank:DB00994]

AC-(D)PHE-PRO-BOROLYS-OH
AC-(D)PHE-PRO-BOROLYS-OH [drugbank:DB07658]

17-Dmag
17-Dmag [drugbank:DB03080]

4-Deoxy-4-Amino-Beta-D-Glucose
4-Deoxy-4-Amino-Beta-D-Glucose [drugbank:DB03291]

Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas. Headache and gastrointestinal disturbances have been reported in patients taking bentiromide. Bentiromide is not available in the U.S. or Canada (It was withdrawn in the US in October 1996).
Bentiromide
Bentiromide [drugbank:DB00522]

2,6-Diaminoquinazolin-4(3h)-One
2,6-Diaminoquinazolin-4(3h)-One [drugbank:DB03505]

4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide [drugbank:DB06938]

[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE [drugbank:DB06927]

Buserelin is a luteinizing hormone-releasing hormone (LHRH) agonist, a synthetic hormone which stimulates the pituitary gland's gonadotrophin-releasing hormone receptor (GnRHR). It is used in prostate cancer treatment.
Buserelin
Buserelin [drugbank:DB06719]

A starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function. [PubChem]
Inulin
Inulin [drugbank:DB00638]

An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. [PubChem]
Hydroxyurea
Hydroxyurea [drugbank:DB01005]

2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE
2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE [drugbank:DB07984]

AT3022, the Altea Therapeuticsâs fentanyl citrate transdermal patch designed to provide safe and rapid management of moderate to severe chronic pain.
AT3022
AT3022 [drugbank:DB05172]

N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE
N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE [drugbank:DB07165]

1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE [drugbank:DB07783]

The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. [Wikipedia]
Bafilomycin A1
Bafilomycin A1 [drugbank:DB06733]

5(R)-5-Fluoro-Beta-D-Xylopyranosyl-Enzyme Intermediate
5(R)-5-Fluoro-Beta-D-Xylopyranosyl-Enzyme Intermediate [drugbank:DB03586]

SLV319 belongs to a novel class of agents called CB1 antagonists, which work by blocking the cannabinoid type 1 (CB1) receptor. It is developed for the treatment of obesity and other metabolic disorders.
SLV319
SLV319 [drugbank:DB05077]

LATRUNCULIN B
LATRUNCULIN B [drugbank:DB08080]

A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. [PubChem]
Methazolamide
Methazolamide [drugbank:DB00703]

Acetylamino-Acetic Acid
Acetylamino-Acetic Acid [drugbank:DB02713]

Dihydro-Acarbose
Dihydro-Acarbose [drugbank:DB04226]

GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE
GLYCYLALANYL-N-2-NAPHTHYL-L-PROLINEAMIDE [drugbank:DB07813]

MF101 is a novel estrogen receptor beta (ERÎ²) selective agonist and unlike currently available hormone therapies, does not activate the estrogen receptor alpha (ERÎ±), known to be implicated in tumor formation. MF101 is an oral drug designed for the treatment of hot flashes and night sweats in peri-menopausal and menopausal women.
MF101
MF101 [drugbank:DB05052]

Autologous fibroblast transplant is an innovative cellular processing system which creates a natural, living cell therapy. By multiplying a patientâs own collagen-producing cells or fibroblasts into tens of millions of new cells, a personalized treatment is created which is then returned to the patientâs skin. This treatment, known as the Isolagen Therapyâ¢, is designed to improve skin damage caused by the normal effects of aging, sun damage, acne and burns.
autologous fibroblast transplant
autologous fibroblast transplant [drugbank:DB05348]

Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues. It is a heterodimeric glycoprotein. Each monomeric unit is a glycoprotein molecule. In females, an acute rise of LH ("LH surge") triggers ovulation and the development of the corpus luteum. In males, it stimulates Leydig cell production of testosterone. Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for use in the stimulation of follicular development.
Lutropin alfa
Lutropin alfa [drugbank:DB00044]

4-(3,5-DIMETHYLPHENOXY)-5-(FURAN-2-YLMETHYLSULFANYLMETHYL)-3-IODO-6-METHYLPYRIDIN-2(1H)-ONE
4-(3,5-DIMETHYLPHENOXY)-5-(FURAN-2-YLMETHYLSULFANYLMETHYL)-3-IODO-6-METHYLPYRIDIN-2(1H)-ONE [drugbank:DB08457]

5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE [drugbank:DB07794]

PRO 2000 is an investigational medicine that is not yet approved by the FDA for use outside of clinical trials. It is being studied for the prevention of HIV infection and other sexually transmitted diseases. This medicine does not cure HIV infection or AIDS and is being studied to reduce the risk of passing the virus to other people.
PRO 2000
PRO 2000 [drugbank:DB05385]

Alfuzosin (INN, provided as the hydrochloride salt) is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. [Wikipedia]
Alfuzosin
Alfuzosin [drugbank:DB00346]

1-(5-Carboxypentyl)-5-[(2,6-Dichlorobenzyl)Oxy]-1 H-Indole-2-Carboxylic Acid
1-(5-Carboxypentyl)-5-[(2,6-Dichlorobenzyl)Oxy]-1 H-Indole-2-Carboxylic Acid [drugbank:DB02316]

Histidinol
Histidinol [drugbank:DB03811]

3-(7-Hydroxy-8-Ribityllumazine-6-Yl) Propionic Acid
3-(7-Hydroxy-8-Ribityllumazine-6-Yl) Propionic Acid [drugbank:DB04262]

Nicotinamide Adenine Dinucleotide 3-Pentanone Adduct
Nicotinamide Adenine Dinucleotide 3-Pentanone Adduct [drugbank:DB04421]

N-Benzyl-4-Sulfamoyl-Benzamide
N-Benzyl-4-Sulfamoyl-Benzamide [drugbank:DB01748]

4-PIPERIDIN-4-YLBUTANAL
4-PIPERIDIN-4-YLBUTANAL [drugbank:DB04654]

Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It is indicated for the management of signs and symptoms of Parkinsonian Syndrome. Bromocriptine also inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. It also causes sustained suppression of somatotropin (growth hormone) secretion in some patients with acromegaly. Bromocriptine has been associated with pulmonary fibrosis.
Bromocriptine
Bromocriptine [drugbank:DB01200]

N-Pyridoxyl-2-Methylalanine-5-Phosphate
N-Pyridoxyl-2-Methylalanine-5-Phosphate [drugbank:DB04241]

4-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE
4-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE [drugbank:DB08598]

{(1s)-1-Benzyl-4-[3-Carbamoyl-1-(1-Carbamoyl-2-Phenyl-Ethylcarbamoyl)-(S)-Propylcarbamoyl]-2-Oxo-5-Phenyl-Pentyl}-Carbamic Acid Tert-Butyl Ester
{(1s)-1-Benzyl-4-[3-Carbamoyl-1-(1-Carbamoyl-2-Phenyl-Ethylcarbamoyl)-(S)-Propylcarbamoyl]-2-Oxo-5-Phenyl-Pentyl}-Carbamic Acid Tert-Butyl Ester [drugbank:DB04353]

naphthalene-1,2,4,5,7-pentol
naphthalene-1,2,4,5,7-pentol [drugbank:DB06915]

Fica
Fica [drugbank:DB03384]

Ammonium lactate is the ammonium salt of lactic acid.
Ammonium lactate
Ammonium lactate [drugbank:DB06768]

3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE
3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE [drugbank:DB07474]

[N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
[N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE [drugbank:DB08763]

2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL
2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL [drugbank:DB06832]

Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
Cefixime
Cefixime [drugbank:DB00671]

3-(4-Phenylamino-Phenylamino)-2-(1h-Tetrazol-5-Yl)-Acrylonitrile
3-(4-Phenylamino-Phenylamino)-2-(1h-Tetrazol-5-Yl)-Acrylonitrile [drugbank:DB04430]

Liposome-encapsulated form of prostaglandin E1 (Liprostin) is known to be a potent vasodilator and platelet inhibitor as well as an anti-inflammatory and anti-thrombotic agent. The liposomal formulation of PGE-1 changes the drugâs dynamics and improve its therapeutic index in ways that PGE-1 alone could not achieve.
liposomal prostaglandin E1
liposomal prostaglandin E1 [drugbank:DB05391]

A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia. [PubChem]
Ethoxzolamide
Ethoxzolamide [drugbank:DB00311]

Strontium malonate is being developed as a novel orally available pharmaceutical for the treatment and prevention of osteoporosis. It is being developed by Osteologix Inc.
Strontium malonate
Strontium malonate [drugbank:DB05732]

2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione
2,3,7,8-tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione [drugbank:DB08468]

5-Mercapto-2-Nitro-Benzoic Acid
5-Mercapto-2-Nitro-Benzoic Acid [drugbank:DB02763]

PARA-NITROBENZYL GLUTARYL GLYCINIC ACID
PARA-NITROBENZYL GLUTARYL GLYCINIC ACID [drugbank:DB08410]

(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
(S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE [drugbank:DB07855]

Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.
Abiraterone
Abiraterone [drugbank:DB05812]

Lercanidipine is a calcium channel blocker of the dihydropyridine class.

It is sold under various commercial names including Zanidip.

Lercanidipine
Lercanidipine [drugbank:DB00528]

N-(Chlorophenyl)-N'-Hydroxyguanidine
N-(Chlorophenyl)-N'-Hydroxyguanidine [drugbank:DB04559]

S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE [drugbank:DB07769]

Recombinant humanized IgG4, kappa antibody conjugated with a cytotoxic antitumor antibiotic, calicheamicin, isolated from fermentation of a bacterium, Micromonospora echinospora ssp. calichensis. The antibody portion of Mylotarg binds specifically to the CD33 antigen, The anti-CD33 hP67.6 antibody is produced by mammalian cell suspension culture using a myeloma NS0 cell line. Gemtuzumab ozogamicin (trade name Mylotarg) was withdrawn in 2010 when a clinical trial showed the drug increased patient death and exhibited no advantages over traditional cancer therapies.
Gemtuzumab ozogamicin
Gemtuzumab ozogamicin [drugbank:DB00056]

Aminoanthracene
Aminoanthracene [drugbank:DB01976]

4-bromo-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide
4-bromo-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide [drugbank:DB07098]

Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks.
Carbinoxamine
Carbinoxamine [drugbank:DB00748]

An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order tetraodontiformes, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction. Tetrodotoxin is being investigated by Wex Pharmaceuticals for the treatment of chronic and breakthrough pain in advanced cancer patients as well as for the treatment of opioid dependence.
Tetrodotoxin
Tetrodotoxin [drugbank:DB05232]

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
Chlorothiazide
Chlorothiazide [drugbank:DB00880]

Human Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. Alglucerase is prepared by modification of the oligosaccharide chains of human Beta-glucocerebrosidase. The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated with mannose residues
Alglucerase
Alglucerase [drugbank:DB00088]

Ruxolitinib is a janus-associated kinase inhibitor indicated to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis. FDA approved on November 16, 2011.
Ruxolitinib
Ruxolitinib [drugbank:DB08877]

HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE
HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE [drugbank:DB08525]

An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding. [PubChem]
Fenoprofen
Fenoprofen [drugbank:DB00573]

THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE
THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE [drugbank:DB08426]

3,4-DI-1H-INDOL-3-YL-1H-PYRROLE-2,5-DICARBOXYLIC ACID
3,4-DI-1H-INDOL-3-YL-1H-PYRROLE-2,5-DICARBOXYLIC ACID [drugbank:DB07588]

AME-527 is a humanized monoclonal antibody that recognizes human TNF-alpha (hTNF-alpha) with high affinity and specificity. AME-527 was generated by protein engineering and identified from a library of antibody variants based on its improved binding properties.
AME-527
AME-527 [drugbank:DB05879]

5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone
5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone [drugbank:DB03924]

2-CHLORO-4-ETHYLAMINO-6-(S(-)-2'-CYANO-4-BUTYLAMINO)-1,3,5-TRIAZINE
2-CHLORO-4-ETHYLAMINO-6-(S(-)-2'-CYANO-4-BUTYLAMINO)-1,3,5-TRIAZINE [drugbank:DB07551]

Pristinamycin IIA is a macrolide antibiotic. It is a member of the streptogramin A group of antibiotics and one component of pristinamycin (the other being pristinamycin IA). It is produced by Streptomyces graminofaciens and other bacteria.
Virginiamycin M1
Virginiamycin M1 [drugbank:DB01669]

Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Methdilazine
Methdilazine [drugbank:DB00902]

1,3-Propandiol
1,3-Propandiol [drugbank:DB02774]

1-[2-(4-ETHOXY-3-FLUOROPYRIDIN-2-YL)ETHYL]-3-(5-METHYLPYRIDIN-2-YL)THIOUREA
1-[2-(4-ETHOXY-3-FLUOROPYRIDIN-2-YL)ETHYL]-3-(5-METHYLPYRIDIN-2-YL)THIOUREA [drugbank:DB08372]

BV1
BV1 [drugbank:DB04210]

[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID [drugbank:DB07771]

Nd1-Phosphonohistidine
Nd1-Phosphonohistidine [drugbank:DB01899]

1-(2-HYDROXYETHYLOXYMETHYL)-6-PHENYL THIOTHYMINE
1-(2-HYDROXYETHYLOXYMETHYL)-6-PHENYL THIOTHYMINE [drugbank:DB07892]

A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
Hexamethonium
Hexamethonium [drugbank:DB08960]