http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_head http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_assertion http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_provenance http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_assertion http://identifiers.org/ncbigene/1080 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0011849 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/gene-disease-association.ttl#DGNf908b743363eeb0c30a721f66cae2958 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/1080 http://rdf.disgenet.org/gene-disease-association.ttl#DGNf908b743363eeb0c30a721f66cae2958 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0011849 http://rdf.disgenet.org/gene-disease-association.ttl#DGNf908b743363eeb0c30a721f66cae2958 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_provenance http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_assertion http://purl.org/dc/terms/description [The proposed mechanism is supported by several pieces of evidence including: (1) the absolute essentiality of an intact unfolded protein response (UPR) machinery for survival of pancreatic beta-cells, (2) the high susceptibility of beta-cells to prolonged ER stress leading to induction of pro-apoptotic factors and apoptosis pathways in beta-cells, (3) CF patients with mutations in CFTR gene that are engaging the ER quality control system (ERAD) and hence UPR signalling are twenty time more likely to develop diabetes than those with other types of CF-causing mutations, and (4) the high levels of CFTR gene expression in pancreatic islet cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/18851900 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/eco.owl#ECO_0000203 http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://purl.org/pav/2.0/importedOn 2014-02-25 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000212 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/dc/terms/created 2014-10-02T12:36:06+02:00 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v2.1.0/void.ttl#IBIGroup http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/pav/2.0/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP414677.RAzsEzVxHYHwQHZ0PIWCwoydyQxW65xSM14QTxQ6TjFlY http://purl.org/pav/2.0/version v2.1.0.0 http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://purl.org/pav/2.0/version v2.1.0