. . . . . . . . . . . . . . "cat(p(HGNC:CYP1B1)) -> a(CHEBI:estradiol)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "The two main CYP enzymes that are up-regulated by cigarette smoke are CYP1A1 and CYP1B1, which are regulated by ER{alpha} (18). Stimulation of estrogen receptor in the lungs increases protein expression of CYP1A1 by twofold (17). The increased CYP expression is also related to increased estradiol-? expression (19). CYPs are also involved in the bioactivation of 17?-estradiol, resulting in a positive feedback loop" . . "Selventa" . . . . "2014-07-03T14:33:13.930+02:00"^^ . . .