. . . . . . . . . . . . . . . . . . . . "phos(p(HGNC:PTPN11)) =| kin(p(HGNC:JAK2))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "SHP-2 binds to these residues on the leptin receptor via different sites [56]. Binding of SHP-2 to Y985 occurs via a SH2 domain and results in the activation of the enzyme, whereas Y974 likely associates with the active site of the enzyme SHP-2 binds to phosphotyrosine 986, becomes activated and can thus down-regulate further tyrosine phosphorylation-dependent leptin signalling such as STAT3 activation in the hypothalamus." . . "Selventa" . . . . "2014-07-03T14:31:49.254+02:00"^^ . . .