@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v4.0.0/void/> .

dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_head {
  this: np:hasAssertion dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_assertion;
    np:hasProvenance dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_provenance;
    np:hasPublicationInfo dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_assertion a np:Assertion .
  
  dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_provenance a np:Provenance .
  
  dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_publicationInfo
    a np:PublicationInfo .
}

dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_assertion {
  miriam-gene:2064 a ncit:C16612 .
  
  lld:C0001418 a ncit:C7057 .
  
  dgn-gda:DGN8dfce5de42eecfcc1ce5b593f4a6cefb sio:SIO_000628 miriam-gene:2064, lld:C0001418;
    a sio:SIO_001121 .
}

dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_provenance {
  dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_assertion dcterms:description
      "[Among the findings: peptic ulcer disease is a significant predisposing risk factor (odds ratio = 3.9) for pancreatic cancer; as many as 50% of all intraductal papillary mucinous neoplasms are associated with invasive adenocarcinomas; alteration of gene expression via methylation of a gene promotor region constitutes a potentially reversible method of tumor suppressor gene inactivation; &gt; 400 transcriptional alterations of gene expression have been identified for pancreatic cancer; some common molecular markers such as p53 and HER-2/neu may be related to morphologic alterations of in situ neoplasia and to transcriptional alterations of gene expression rather than mutational events; epidermal growth factor (EGF), transforming growth factor beta (TGF-beta), and related molecules may modulate gene transcription via autocrine or paracrine mechanisms; several cytokines, amylin (islet amyloid polypeptide), and other cachexia factors are responsible for paraneoplastic peripheral insulin resistance, ineffective utilization of glucose, and profound cachexia.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:9821173;
    prov:wasDerivedFrom dgn-void:befree-2016;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP1409092.RAzbfF_Qj17snfFC2KKiHLfyYB8QvpHUXoYVCG_x6FU2M130_publicationInfo {
  this: dcterms:created "2016-05-13T12:52:25+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v4.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v4.0.0" .
}