@prefix this: <http://purl.org/np/RAza6OegZBspU4MyGfe_LuRyxrhfN03TKYVHfssHHuEYE> .
@prefix sub: <http://purl.org/np/RAza6OegZBspU4MyGfe_LuRyxrhfN03TKYVHfssHHuEYE#> .
@prefix drugbank: <http://identifiers.org/drugbank/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix mondo: <http://purl.obolibrary.org/obo/MONDO_> .
@prefix pav: <http://purl.org/pav/> .
@prefix infores: <https://w3id.org/biolink/infores/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix ntemplate: <https://w3id.org/np/o/ntemplate/> .
@prefix orcid: <https://orcid.org/> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix pmid: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix biolink: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubInfo ;
    a np:Nanopublication .
}
sub:assertion {
   drugbank:DB00363 a biolink:Drug ;
    rdfs:label "clozapine" ;
    biolink:category biolink:Drug .
  mondo:0008114 a biolink:Disease ;
    rdfs:label "obsessive-compulsive disorder" ;
    biolink:category biolink:Disease .
  sub:association rdf:object mondo:0008114 ;
    rdf:predicate biolink:treats ;
    rdf:subject drugbank:DB00363 ;
    a biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    rdfs:label "Clozapine is not recommended for OCD due to poor evidence of efficacy [170]. In addition, several case reports and clinical studies support the association of clozapine with worsening or onset of obsessive-compulsive symptoms in patients with a psychotic disorder [171-176]. At least 20% of individuals treated with clozapine (and other antiserotonergic antipsychotics) would experience worsening or emergence of obsessive-compulsive symptoms [177], which are dose-related [178] and generally reversible upon discontinuation of clozapine treatment and switch to a different antipsychotic [179]" ;
    biolink:aggregator_knowledge_source infores:knowledge-collaboratory ;
    biolink:category biolink:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    biolink:has_population_context sub:context ;
    biolink:publications pmid:30101713 ;
    biolink:relation ncit:C94303 .
  sub:context a biolink:Cohort ;
    rdfs:label "adults" ;
    biolink:category biolink:Cohort .
}
sub:provenance {
   sub:assertion prov:wasAttributedTo orcid:0000-0002-7641-6446 .
}
sub:pubInfo {
   sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB" ;
    npx:hasSignature "IsaYQcqG4/ByvsmkRNQkrMu0GMoGb4jVZthrPRXpM5cR9OM/c6UQsLAFxgyvSCt4etAS1FhW/vR2aRMRbDekxhY7TSTcm+TqJnN7dd/1fa17MeNABon/Nfeb5yNVxNL7TZ1jBNoOuZ+//nXHoyIe+E4OI/gAvJ8sNgrVIxOywHc=" ;
    npx:hasSignatureTarget this: .
  this: prov:generatedAtTime "2022-09-16T11:53:42.407140"^^xsd:dateTime ;
    prov:wasAttributedTo orcid:0000-0002-1501-1082 ;
    ntemplate:wasCreatedFromTemplate <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
  biolink: pav:version "2.3.0" .
}