http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#Head http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#assertion http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#provenance http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#assertion http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:88439 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:104798 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_2 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=6494 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_3 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_1 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:lipopolysaccharide) -> r(MGI:Tnf) http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Cntf) -| (a(CHEBI:lipopolysaccharide) -> r(MGI:Tnf)) http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_5 http://www.w3.org/ns/prov#value Ciliary neurotrophic factor (CNTF) inhibits the production of tumor necrosis factor (TNF) in lipopolysaccharide (LPS)-treated mice and protects against LPS lethality when coadministered with its soluble receptor (sCNTFR alpha). Both of these activities are abolished in adrenalectomized (ADX) mice. LPS-induced pulmonary polymorphonuclear neutrophil (PMN) infiltration and nitric oxide (NO) production were also inhibited by CNTF + sCNTFR alpha but not by CNTF alone. sCNTFR alpha did not alter the clearance or tissue distribution of CNTF. Furthermore, CNTF variants coadministered with sCNTFR alpha protected against LPS toxicity in a manner related to their affinity for the beta components of CNTFR. Thus, inhibition of TNF production and protection against LPS lethality by CNTF/sCNTFR alpha require an intact hypothalamus-pituitary-adrenal axis (HPAA) and may be mediated by endogenous glucocorticoids. This protective effect is, at least in part, due to the inhibition of PMN infiltration and NO production, and appears to be mediated by cells displaying only beta-receptor subtypes. http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9656141 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9656141 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#_5 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw http://purl.org/dc/terms/created 2014-07-03T14:34:11.398+02:00 http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAza39OQLenEyI9Piv8Kui2J0kaQNfhgJzC0z67Kd35Xw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234