@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAzI1KhJ5fXWWJcAydd0QT0vW-lPU3a1-gEndNRIwpLuI> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAzI1KhJ5fXWWJcAydd0QT0vW-lPU3a1-gEndNRIwpLuI#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/> .
@prefix rgd: <http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 belv:variantOf rgd:1311235;
    a proteinModification:, psimod:00696 .
  
  sub:_2 occursIn: obo:UBERON_0004237, species:10116;
    rdf:object sub:_1;
    rdf:predicate belv:decreases;
    rdf:subject schem:cyclic%20AMP;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(SCHEM:\"cyclic AMP\") -| p(RGD:Myl9,pmod(P,T,18))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "20131211" .
  
  sub:_3 dce:identifier "Cardiovascular Physiology Concepts";
    dce:title "Cardiovascular Physiology Concepts";
    dce:type "Other" .
  
  sub:_4 prov:value "The Gs-protein coupled pathway stimulates adenylyl cyclase (AC) that catalyzes the formation of cAMP.  In VSM, unlike the heart, an increase in cAMP stimulated by a b2-adrenoceptor agonist such as epinephrine or isoproterenol causes relaxation.  The mechanism for this is cAMP inhibition of MLCK. Therefore, increased cAMP decreases MLC phosphorylation, which decreases the interactions between actin and myosin.  Therefore, drugs which increase cAMP (e.g., b2-adrenoceptor agonists, phosphodiesterase inhibitors) cause vasodilation.";
    prov:wasQuotedFrom sub:_3 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource sub:_3;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:31:29.026+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}