@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAzEGw3ZKleWdXkvWpJFipuQcWvB9TwJuUzmX7LaJgn6I> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAzEGw3ZKleWdXkvWpJFipuQcWvB9TwJuUzmX7LaJgn6I#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix rgd: <http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: rgd:1311069;
    a Protein: .
  
  sub:_2 belv:variantOf rgd:2939;
    a proteinModification:, psimod:00696 .
  
  sub:_3 occursIn: species:10116;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(RGD:Mpl) -> p(RGD:Jak2,pmod(P))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "1.4" .
  
  sub:_4 prov:value "Treatment of hippocampal neurons with thrombopoietin (TPO) for 15 hours at concentrations as low as 10 pM, increased the spontaneous cell death rate by >60%; treatment with AG-490 (20 microM), an inhibitor of JAK2-transphosphorylation, and PD-98059 (50 microM), an inhibitor of ERK1/2, completely eliminated TPO-induced neuronal death, as did the caspase-3 inhibitor Ac-VAD-CHO (50 microM), suggesting that receptor mediated activation of JAK2 and ERK1/2 are involved in caspase-3 activation and cell death in TPO treated hippocampal neurons.";
    prov:wasQuotedFrom pubmed:15642952 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15642952;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:30.797+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}