. . . . . . . . . . . . . . "p(RGD:Mpl) -> p(RGD:Jak2,pmod(P))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Treatment of hippocampal neurons with thrombopoietin (TPO) for 15 hours at concentrations as low as 10 pM, increased the spontaneous cell death rate by >60%; treatment with AG-490 (20 microM), an inhibitor of JAK2-transphosphorylation, and PD-98059 (50 microM), an inhibitor of ERK1/2, completely eliminated TPO-induced neuronal death, as did the caspase-3 inhibitor Ac-VAD-CHO (50 microM), suggesting that receptor mediated activation of JAK2 and ERK1/2 are involved in caspase-3 activation and cell death in TPO treated hippocampal neurons." . . "Selventa" . . . . "2014-07-03T14:30:30.797+02:00"^^ . . .