sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Treatment of hippocampal neurons with thrombopoietin (TPO) for 15 hours at concentrations as low as 10 pM, increased the spontaneous cell death rate by >60%; treatment with AG-490 (20 microM), an inhibitor of JAK2-transphosphorylation, and PD-98059 (50 microM), an inhibitor of ERK1/2, completely eliminated TPO-induced neuronal death, as did the caspase-3 inhibitor Ac-VAD-CHO (50 microM), suggesting that receptor mediated activation of JAK2 and ERK1/2 are involved in caspase-3 activation and cell death in TPO treated hippocampal neurons." ;
    prov:wasQuotedFrom pubmed:15642952 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15642952 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}