@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v4.0.0/void/> .

dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_head {
  this: np:hasAssertion dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_assertion;
    np:hasProvenance dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_provenance;
    np:hasPublicationInfo dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_assertion a np:Assertion .
  
  dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_provenance a np:Provenance .
  
  dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_publicationInfo
    a np:PublicationInfo .
}

dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_assertion {
  miriam-gene:7157 a ncit:C16612 .
  
  lld:C0085110 a ncit:C7057 .
  
  dgn-gda:DGNcd1abd85f7e6486b5f9d3c6b875297fc sio:SIO_000628 miriam-gene:7157, lld:C0085110;
    a sio:SIO_001121 .
}

dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_provenance {
  dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_assertion dcterms:description
      "[In the clinical diagnostic arena: the World Health Organization established a standard nomenclature for intraductal papillary mucinous neoplasms, mucinous cystic tumors, intraductal mucinous hyperplasias, and solid pseudopapillary tumors; focal glandular differentiation may be commonly identified within pancreatic endocrine neoplasms (islet cell tumors) while not necessarily implying an unfavorable prognosis typical of ductal adenocarcinomas; positron emission tomography scanning may be used for evaluation of early tumor response to novel chemotherapeutic regimens; helical computed tomography (CT) is the state of the art in preoperative imaging for pancreatic cancer; neoadjuvant 5-fluorouracil (5-FU)-based chemoradiation in 39 resectable patients provided a median survival of 19 months, actuarial 4-year survival of 19%, and improved local tumor control; gemcitabine has shown promise in alleviating tumor-related symptoms with a significantly better clinical benefit response than single agent 5-FU (23.8 vs. 4.8%, p = 0.0022) based on change in pain intensity, daily analgesic consumption, performance status, and weight; a significant survival advantage was demonstrated in patients treated with conventional therapies whose tumors expressed p21WAF-1, an important inhibitor of cell cycle progression and downstream molecule of p53 and TGF-beta; a p21-adenovirus (rAD-p21) gene therapy resulted in significant growth inhibition of pancreatic cancer cell lines in tissue culture, and development of a successful SCID mouse-human pancreatic adenocarcinoma xenograft model provided an animal model for preclinical trials of rAD-p21.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:9821173;
    prov:wasDerivedFrom dgn-void:befree-2016;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP1409086.RAynKNuVtvzenYoiKVrt89ILKQ9bg1QJgQXN_SDB4ey5Y130_publicationInfo {
  this: dcterms:created "2016-05-13T12:52:25+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v4.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v4.0.0" .
}