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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#_3 http://www.w3.org/ns/prov#value Butyrate and other short-chain fatty acids (SCFAs) are found at high concentrations in the colonic lumen and affect multiple epithelial cell functions. To better understand how SCFAs regulate ion transport, we investigated the effects of SCFAs on Cl(-) secretion in human colonic epithelial cell line T(84). Butyrate inhibited Cl(-) secretory responses to prostaglandin E(2), forskolin, and cholera toxin. Other SCFAs were less effective or inactive. Reduced secretion was associated with decreased synthesis of the second messenger cAMP rather than increased degradation. Expression and activity of adenylyl cyclase were decreased by butyrate, whereas phosphodiesterase activity was unaffected and phosphodiesterase inhibition did not reverse the effects of butyrate on Cl(-) secretion. Furthermore, butyrate decreased expression of the basolateral Na-K-2Cl cotransporter, indicating that it might modulate the secretory capacity of the cells. However, butyrate did not affect secretory responses to the calcium-dependent secretagogue carbachol, cAMP analogs, or uroguanylin, indicating that normal secretory responses to adequate levels of second messengers in butyrate-treated T(84) cells are possible. These results show that butyrate affects several aspects of epithelial Cl(-) secretion, including second messenger generation and expression of key ion transporters. However, these effects may not all be equally important in determining Cl(-) secretion in response to physiologically relevant secretagogues. http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11698242 http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11698242 http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#_3 http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk http://purl.org/dc/terms/created 2014-07-03T14:31:44.537+02:00 http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAyY2IT1XN1Qqa3bkGLRtBwh6ElIEyXdcpyCP0vMEbKuk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234