http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#Head http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#assertion http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#provenance http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#assertion http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D042783 http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://amigo.geneontology.org/amigo/term/GO:0042311 http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-diseases/laminar%20shear%20stress http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#assertion http://www.w3.org/2000/01/rdf-schema#label path(SDIS:"laminar shear stress") -> bp(GO:vasodilation) http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_2 http://www.w3.org/ns/prov#value Shear stress is the tangential force of the flowing blood on the endothelial surface of the blood vessel. Shear is described mathematically or ideal fluids, and in vitro models have enabled researchers to describe the effects of shear on endothelial cells. High shear stress, as found in laminar flow, promotes endothelial cell survival and quiescence, alignment in the direction of flow, and secretion of substances that promote vasodilation and anticoagulation. Low shear stress, or changing shear stress direction as found in turbulent flow, promotes endothelial proliferation and apoptosis, shape change, and secretion of substances that promote vasoconstriction, coagulation, and platelet aggregation. The precise pathways by which endothelial cells sense shear stress to promote their quiescent or activated pathways are currently unknown. Clinical applications include increasing shear stress via creation of an arteriovenous fistula or vein cuff to promote bypass graft flow and patency. Since an abnormal level of shear stress is implicated in the pathogenesis of atherosclerosis, neointimal hyperplasia, and aneurysmal disease, additional research to understand the effects of shear stress on the blood vessel may provide insight to prevent vascular disease. http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12577139 http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12577139 http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#_2 http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo http://purl.org/dc/terms/created 2014-07-03T14:30:10.006+02:00 http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAyY-beIGr_f2BPsVmm2f2W-foYG1NXD1xRAb8UYXnrTo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234