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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#_3 http://www.w3.org/ns/prov#value Theoretically, under hypoxic conditions, the Fe(II) state is favored in preference to Fe(III), which could result in the release of iron from ferritin or other compartments. The increased amount of Fe(II) could result in two effects: (1) It may be incorporated into the [4Fe-4S] cluster of IRP-1 and decrease RNA-binding activity, and (2) it could result in increased IRP-2 degradation. It is notable that oxidant stress has been shown to have both transcriptional and post-transcriptional effects on ferritin expression.2 Indeed, oxidant stress can directly increase the transcription of the ferritin gene.14 For example, this occurs after exposure to agents which decrease glutathione levels that acts as a defense against free radicals.15 Further, oxidant stress can inactivate IRP-1 by oxidizing critical sulfydryl groups of cysteine residues that are important for mRNA binding. http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12761471 http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12761471 http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#_3 http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw http://purl.org/dc/terms/created 2014-07-03T14:32:02.315+02:00 http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAyXYQnqvOyGHaGVoVcPFChf6Xha0Q-IJtYuD2w_1U5sw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234