. . . . . . . . . . "a(CHEBI:camptothecin) -> bp(GOBP:\"cellular response to DNA damage stimulus\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . " In the presence of CPT, topo I forms a covalent intermediate with the 3'-phosphate end of the broken DNA strand (5) . This single-strand nick lesion is believed to convert into an irreversible double-strand break after it encounters the replication fork machinery in S phase. This unusual form of DNA damage induces a signaling cascade that is propagated by ATM-family kinases in human cells (6) , which phosphorylate numerous targets involved in transcription, DNA repair, cell cycle arrest, and apoptosis." . . "Selventa" . . . . "2014-07-03T14:32:18.016+02:00"^^ . . .