sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_3 ;
    pav:version "20131211" .
  sub:_2 prov:value " In the presence of CPT, topo I forms a covalent intermediate with the 3'-phosphate end of the broken DNA strand (5) . This single-strand nick lesion is believed to convert into an irreversible double-strand break after it encounters the replication fork machinery in S phase. This unusual form of DNA damage induces a signaling cascade that is propagated by ATM-family kinases in human cells (6) , which phosphorylate numerous targets involved in transcription, DNA repair, cell cycle arrest, and apoptosis." ;
    prov:wasQuotedFrom pubmed:15026349 .
  sub:_3 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15026349 ;
    prov:wasDerivedFrom beldoc: , sub:_2 .
}