@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAyQKtWuhbZbVsNq6DSOgrU5LV9L9QCumFMI1m9R8zvYI> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAyQKtWuhbZbVsNq6DSOgrU5LV9L9QCumFMI1m9R8zvYI#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 hasAgent: sub:_2 ;
    a go:0016301 .
  sub:_2 geneProductOf: hgnc:9967 ;
    a Protein: .
  sub:_3 hasAgent: sub:_4 ;
    a go:0016301 .
  sub:_4 geneProductOf: hgnc:6876 ;
    a Protein: .
  sub:_5 occursIn: species:9606 ;
    rdf:object sub:_3 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "kin(p(HGNC:RET)) -> kin(p(HGNC:MAPK14))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "1.4" .
  sub:_6 prov:value "Activation of RET, either by ligand or through specific mutations, results in phosphorylation of multiple tyrosine residues that, in turn, interact with specific adaptor molecules to trigger downstream signaling. Four of the tyrosines phosphorylated on RET activation, tyrosines 905, 1015, 1062, and 1096, have been well characterized, and are known to interact with a number of adaptor molecules to stimulate signaling through phosphatidylinositol kinase (PI3K)/AKT, PLC-gamma, RAS/extracellular signal-regulated kinase (ERK), p38MAPK, JNK and ERK5." ;
    prov:wasQuotedFrom pubmed:15231654 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15231654 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:30:25.552+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}