http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#head http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI http://www.nanopub.org/nschema#hasAssertion http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#assertion http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI http://www.nanopub.org/nschema#hasProvenance http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#provenance http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI http://www.nanopub.org/nschema#hasPublicationInfo http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#publicationInfo http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#assertion http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/bio2rdf_vocabulary:identifier DB01016 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/bio2rdf_vocabulary:namespace drugbank http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/bio2rdf_vocabulary:uri http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org http://identifiers.org/drugbank/DB01016 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:drugbank-id APRD00233 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:drugbank-id DB01016 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-ahfs http://bio2rdf.org/ahfs:68:20.20 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-atc http://bio2rdf.org/atc:A10BB01 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-cas http://bio2rdf.org/cas:10238-21-8 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-chebi http://bio2rdf.org/chebi:5441 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-chemspider http://bio2rdf.org/chemspider:3368 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-dpd http://bio2rdf.org/dpd:2248008 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-gtp http://bio2rdf.org/gtp:2414 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-iuphar http://bio2rdf.org/iuphar:2414 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:C07022 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:D00336 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-ndc http://bio2rdf.org/ndc:0378-1113-01 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb http://bio2rdf.org/pharmgkb:PA449782 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound http://bio2rdf.org/pubchem.compound:3488 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance http://bio2rdf.org/pubchem.substance:46509154 http://bio2rdf.org/drugbank:DB01016 http://bio2rdf.org/drugbank_vocabulary:x-wikipedia http://bio2rdf.org/wikipedia:Glibenclamide http://bio2rdf.org/drugbank:DB01016 http://purl.org/dc/terms/description Glyburide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating &beta; cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic &beta; cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Glyburide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Glyburide appears to be completely metabolized, likely in the liver. Although its metabolites exert a small hypoglycemic effect, their contribution to glyburide's hypoglycemic effect is thought to be clinically unimportant. Glyburide metabolites are excreted in urine and feces in approximately equal proportions. The half-life of glyburide appears to be unaffected in those with a creatinine clearance of greater than 29 ml/min/1.73m<sup>2</sup>. http://bio2rdf.org/drugbank:DB01016 http://purl.org/dc/terms/identifier drugbank:DB01016 http://bio2rdf.org/drugbank:DB01016 http://purl.org/dc/terms/title Glyburide http://bio2rdf.org/drugbank:DB01016 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://bio2rdf.org/drugbank_vocabulary:Drug http://bio2rdf.org/drugbank:DB01016 http://www.w3.org/2000/01/rdf-schema#label Glyburide [drugbank:DB01016] http://bio2rdf.org/drugbank:DB01016 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugbank.ca/drugs/DB01016 http://bio2rdf.org/drugbank:DB01016 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.rxlist.com/cgi/generic/glybur.htm http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#provenance http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3 http://www.w3.org/ns/dcat#distribution http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://purl.org/dc/terms/created 2015-01-09T17:00:50-05:00 http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://purl.org/pav/retrievedOn 2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.w3.org/ns/prov#wasAttributedTo http://drugbank.ca http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#publicationInfo http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#signature.MC0CFDvoHcskA4_C http://purl.org/nanopub/x/hasPublicKey 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 http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#signature.MC0CFDvoHcskA4_C http://purl.org/nanopub/x/hasSignature MC0CFDvoHcskA4/C9d/UCoi8QOntLnz8AhUAgUrii96ZmkkzdKWbzURdVwnFjmw= http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#signature.MC0CFDvoHcskA4_C http://purl.org/nanopub/x/signedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI http://purl.org/dc/terms/created 2018-03-30T11:11:10.245+02:00 http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI http://purl.org/dc/terms/license https://creativecommons.org/licenses/by-nc/4.0/ http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI http://purl.org/nanopub/x/hasSignatureElement http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI#signature.MC0CFDvoHcskA4_C http://bio2rdf.org/drugbank:DB01016_nanopub.RAy90aiIrZcpzUBJ3QXAl4x4NVcR-Bdjubm8jY3a1selI http://www.w3.org/ns/prov#wasGeneratedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#specializationOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://purl.org/dc/terms/identifier 7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#used https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasAssociatedWith https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasStartedBy http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/dc/terms/isVersionOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/pav/version eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234