[ { "@graph" : [ { "@id" : "http://bio2rdf.org/drugbank:DB00673", "http://bio2rdf.org/drugbank_vocabulary:ddi-interactor-in" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285" } ] }, { "@id" : "http://bio2rdf.org/drugbank:DB01285", "http://bio2rdf.org/drugbank_vocabulary:ddi-interactor-in" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285" } ] }, { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285", "@type" : [ "http://bio2rdf.org/drugbank_vocabulary:Drug-Drug-Interaction" ], "http://purl.org/dc/terms/identifier" : [ { "@value" : "drugbank_resource:DB00673_DB01285" } ], "http://purl.org/dc/terms/title" : [ { "@language" : "en", "@value" : "DDI between Aprepitant and Corticotropin - Aprepitant may increase the serum concentration of Corticosteroids (Systemic). Monitor for increased effects of systemic corticosteroids when coadmininistered with aprepitant; corticosteroid dose reduction may be necessary. The manufacturer of fosaprepitant (a prodrug of aprepitant) states that oral dexamethasone doses should be reduced by 50% when coadministered with a fosaprepitant/aprepitant regimen to achieve dexamethasone concentrations similar to those achieved with dexamethasone alone. Dexamethasone doses used in clinical chemotherapy nausea/vomiting studies with aprepitant reflect this 50% decrease. Similarly, it is recommended that in order to achieve concentrations similar to those achieved with methylprednisolone alone, the intravenous methylprednisolone dose should be reduced by 25% and the oral methylprednisolone dose should be reduced by 50% when given together with a fosaprepitant/aprepitant regimen." } ], "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@language" : "en", "@value" : "DDI between Aprepitant and Corticotropin - Aprepitant may increase the serum concentration of Corticosteroids (Systemic). Monitor for increased effects of systemic corticosteroids when coadmininistered with aprepitant; corticosteroid dose reduction may be necessary. The manufacturer of fosaprepitant (a prodrug of aprepitant) states that oral dexamethasone doses should be reduced by 50% when coadministered with a fosaprepitant/aprepitant regimen to achieve dexamethasone concentrations similar to those achieved with dexamethasone alone. Dexamethasone doses used in clinical chemotherapy nausea/vomiting studies with aprepitant reflect this 50% decrease. Similarly, it is recommended that in order to achieve concentrations similar to those achieved with methylprednisolone alone, the intravenous methylprednisolone dose should be reduced by 25% and the oral methylprednisolone dose should be reduced by 50% when given together with a fosaprepitant/aprepitant regimen. [drugbank_resource:DB00673_DB01285]" } ] } ], "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#assertion" }, { "@graph" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#publicationInfo" } ] } ], "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#head" }, { "@graph" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#assertion", "http://semanticscience.org/resource/SIO_000253" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3" } ] } ], "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#provenance" }, { "@graph" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2018-03-30T11:13:01.377+02:00" } ], "http://purl.org/dc/terms/license" : [ { "@id" : "https://creativecommons.org/licenses/by-nc/4.0/" } ], "http://purl.org/nanopub/x/hasSignatureElement" : [ { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#signature.MC0CFQCF6PW5uSW_" } ], "http://www.w3.org/ns/prov#wasGeneratedBy" : [ { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.3c184e6c-ceb8-4275-a679-71dfbdac2a11" } ] }, { "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#signature.MC0CFQCF6PW5uSW_", "http://purl.org/nanopub/x/hasPublicKey" : [ { "@value" : "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" } ], "http://purl.org/nanopub/x/hasSignature" : [ { "@value" : "MC0CFQCF6PW5uSW/sHqsAAeztl9Tu5sqbQIUS9JwmB82emeSu4qnceqEIfHyL+U=" } ], "http://purl.org/nanopub/x/signedBy" : [ { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB" } ] }, { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB", "http://www.w3.org/ns/prov#specializationOf" : [ { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub" } ], "http://www.w3.org/ns/prov#wasAttributedTo" : [ { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] }, { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.3c184e6c-ceb8-4275-a679-71dfbdac2a11", "http://purl.org/dc/terms/identifier" : [ { "@value" : "3c184e6c-ceb8-4275-a679-71dfbdac2a11" } ], "http://www.w3.org/ns/prov#used" : [ { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349" } ], "http://www.w3.org/ns/prov#wasAssociatedWith" : [ { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB" } ], "http://www.w3.org/ns/prov#wasStartedBy" : [ { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] }, { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349", "http://purl.org/dc/terms/isVersionOf" : [ { "@id" : "https://github.com/tkuhn/bio2rdf2nanopub" } ], "http://purl.org/pav/version" : [ { "@value" : "eda7951a5f6c622c5d2132f50c3093138484a349" } ], "http://www.w3.org/ns/prov#wasAttributedTo" : [ { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://bio2rdf.org/drugbank_resource:DB00673_DB01285_nanopub.RAy6-IDEPhdziQeB9cArgySyA1ps67Qia4-kzvFxHPqlw#publicationInfo" } ]