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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#_5 http://www.w3.org/ns/prov#value All four resistant lines contained a monoallelic point mutation in the PPAR{gamma} gene at codon 422 resulting in a change from lysine (Lys) to glutamine (Gln) (K422Q); this mutation was not found in the four sensitive cell lines (Table I). The correlation between the K422Q allele and lack of sensitivity to PPAR{gamma} ligands provided suggestive, but not definitive, evidence that this mutation caused the HCT 15, MIP 101, Clone A, and COLO 205 cell lines to be resistant to the growth inhibitory effects of PPAR{gamma} ligands. http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12591919 http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12591919 http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#_5 http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs#pubinfo http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs http://purl.org/dc/terms/created 2014-07-03T14:31:59.010+02:00 http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAy5gDMOtf5bFeazgqjBAac4hN9-0srGzsYVMKS8uGsFs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234