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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#_4 http://www.w3.org/ns/prov#value we determined whether the oxidative stress that occurs in response to T. cruzi infection contributes to the catalytic impairment of respiratory complexes and to subsequent mitochondrial dysfunction in murine myocardium. Our data show that oxidative injuries, as determined by the levels of lipid peroxides and protein carbonyls, are incurred in cardiac mitochondria as early as 3 days postinfection and persist throughout the infection and disease. We observed substantial carbonylation of the specific subunits of mitochondrial respiratory complexes in infected murine hearts. Of note is the oxidative modification of NDUFS1, NDUFS2, and NDUFV1, which form the catalytic core of the CI complex; UQCRC1, UQCRC2, and UQCRQ, the subunits of the core subcomplex, and UQCRH and CYC1, which form the cyt c(1) subcomplex of CIII; and a gamma chain that is essential for ATP synthesis by CV complex. The extent of oxidative modifications of the subunits correlated with the catalytic defects of the respiratory complexes in the infected myocardium. Taken together, our data demonstrate that respiratory complexes are oxidatively damaged in response to the stress of T. cruzi infection. These data also suggest involvement of the specific susceptibility of the protein subunits, and not generalized mitochondrial oxidative damage in respiratory chain impairment of chagasic hearts. http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15544925 http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15544925 http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#_4 http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A#pubinfo http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A http://purl.org/dc/terms/created 2014-07-03T14:30:29.567+02:00 http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAxkLV9EB6sWeAEZ8BLzaRtgmpQoiQ32Myx05UWlb8b4A http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234