. . . . . . . . . . . . "[In Goto-Kakizaki rats used as a model of type 2 diabetes, we examined: (1) whether differences in hepatic aPKC and PKB activation reflect differences in activation of IRS-1- and IRS-2-dependent phosphatidylinositol 3-kinase (PI3K); (2) whether hepatic SREBP-1c and NFkappaB are excessively activated by aPKC; and (3) metabolic consequences of excessive activation of hepatic aPKC, SREBP-1c and NFkappaB.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2016-01-25"^^ . . "Gene-disease associations inferred from animal model manually asserted gene-disease associations."@en . "DisGeNET evidence - PREDICTED"@en . "2016-05-13T12:42:16+02:00"^^ . . . . . . . . . . . "v4.0.0.0" . "v4.0.0" .