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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#_4 http://www.w3.org/ns/prov#value We recently identified three powerful RET inhibitors: two pyrazolo-pyrimidines: 4-amino-5-(4-methylphenyl)- 7-(t-butyl)pyrazolo[3,4-d]-pyrimidine (PP1) and 4-amino- 5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine) (PP2), and an anilino- quinazoline: N (4 bromo 2 fluorophenyl) 6 methoxy 7 (1 methylpiperidin 4 yl) methoxy quinazolin 4 amine (ZD6474) [86 88]. These compounds showed half-maximal RET inhibitory concentrations in the nanomolar range (100 nM). When injected into nude mice, fibroblasts transfected with oncogenic RET lost morphological transformation, proliferative autonomy, anchorage-independent growth and tumorigenicity. In addition to inhibition of RET phosphorylation, PP1 induces RET destruction through proteosomal degradation [89]. http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15583857 http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15583857 http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#_4 http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#pubinfo http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c http://purl.org/dc/terms/created 2014-07-03T14:30:30.122+02:00 http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234