@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016301 .
  
  sub:_2 geneProductOf: mgi:97902;
    a Protein: .
  
  sub:_3 occursIn: mesh:D005347, species:10090;
    rdf:object sub:_1;
    rdf:predicate belv:decreases;
    rdf:subject schem:ZD6474;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(SCHEM:ZD6474) -| kin(p(MGI:Ret))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_5;
    pav:version "1.4" .
  
  sub:_4 prov:value "We recently identified three powerful RET inhibitors: two pyrazolo-pyrimidines: 4-amino-5-(4-methylphenyl)- 7-(t-butyl)pyrazolo[3,4-d]-pyrimidine (PP1) and 4-amino- 5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine) (PP2), and an anilino- quinazoline: N (4 bromo 2 fluorophenyl) 6 methoxy 7 (1 methylpiperidin 4 yl) methoxy quinazolin 4 amine (ZD6474) [86 88]. These compounds showed half-maximal RET inhibitory concentrations in the nanomolar range (100 nM). When injected into nude mice, fibroblasts transfected with oncogenic RET lost morphological transformation, proliferative autonomy, anchorage-independent growth and tumorigenicity. In addition to inhibition of RET phosphorylation, PP1 induces RET destruction through proteosomal degradation [89].";
    prov:wasQuotedFrom pubmed:15583857 .
  
  sub:_5 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15583857;
    prov:wasDerivedFrom beldoc:, sub:_4 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:30.122+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}