sub:provenance {
beldoc: dce:description "Approximately 61,000 statements." ;
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title "BEL Framework Large Corpus Document" ;
pav:authoredBy sub:_7 ;
pav:version "1.4" .
sub:_6 prov:value "10-Hz train stimulation also caused changes in expression of a MEF2-driven luciferase reporter introduced into the fibers via an adenoviral construct (Wilkins et al., 2004). 5 h of repetitive stimulation (5-s duration 10-Hz trains every 50 s) followed by 19 h without stimulation caused luciferase activity in fiber culture extracts to approximately double compared with extracts from parallel unstimulated fiber cultures (Fig. 3 B). The same stimulation (5 h, followed by 19 h without stimulation) in the presence of the CaMK inhibitor KN-62 gave the same luciferase activity as control. Thus, KN-62 completely blocked the stimulation-dependent increase in MEF2 reporter activity, just as KN-62 completely blocked the stimulation-dependent efflux of HDAC4 from the nucleus (Fig. 2)." ;
prov:wasQuotedFrom pubmed:15767461 .
sub:_7 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:15767461 ;
prov:wasDerivedFrom beldoc: ,
sub:_6 .
}