. . . . . . . . . . . . . . . . . . . . . . . . "kin(p(HGNC:EGFR)) -> (p(HGNC:IL6) -> kin(p(SFAM:\"MAPK Erk1/2 Family\")))" . "p(HGNC:IL6) -> kin(p(SFAM:\"MAPK Erk1/2 Family\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "Down-regulation of ErbB receptor activity, through the use of specific pharmacological inhibitors or dominant negative receptor constructs, revealed that IL-6-induced MAPK activation was largely dependent on epidermal growth factor (EGF) receptor activity, but not on ErbB-2 activity. Using a monoclonal antibody that interferes with EGF receptor-ligand interaction, we have shown that in T47D cells, IL-6 cooperates with an EGF receptor autocrine activity loop for signaling through the MAPK and PI3K pathways and for cell migration." . . "Selventa" . . . . "2014-07-03T14:31:39.810+02:00"^^ . . .