http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_head http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_assertion http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_provenance http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_assertion http://identifiers.org/ncbigene/4513 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C0027651 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/gene-disease-association.ttl#DGN6bca26e434f49475f391c8db21163598 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/4513 http://rdf.disgenet.org/gene-disease-association.ttl#DGN6bca26e434f49475f391c8db21163598 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0027651 http://rdf.disgenet.org/gene-disease-association.ttl#DGN6bca26e434f49475f391c8db21163598 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001121 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_provenance http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_assertion http://purl.org/dc/terms/description [Supporting evidence includes the following: [1] expression of constitutive COX-2-catalyzed prostaglandin biosynthesis is induced by most cancer-causing agents including tobacco smoke and its components (polycylic aromatic amines, heterocyclic amines, nitrosamines), essential polyunsaturated fatty acids (unconjugated linoleic acid), mitogens, growth factors, proinflammatory cytokines, microbial agents, tumor promoters, and other epigenetic factors, [2] COX-2 expression is a characteristic feature of all premalignant neoplasms, [3] COX-2 expression is a characteristic feature of all malignant neoplasms, and expression intensifies with stage at detection and cancer progression and metastasis, [4] all essential features of carcinogenesis (mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis, and immunosuppression) are linked to COX-2-driven prostaglandin (PGE-2) biosynthesis, [5] animal studies show that COX-2 up-regulation (in the absence of genetic mutations) is sufficient to stimulate the transformation of normal cells to invasive cancer and metastatic disease, [6] non-selective COX-2 inhibitors, such as aspirin and ibuprofen, reduce the risk of human cancer and precancerous lesions, and [7] selective COX-2 inhibitors, such as celecoxib, reduce the risk of human cancer and precancerous lesions at all anatomic sites thus far investigated.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/17612047 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/eco.owl#ECO_0000203 http://rdf.disgenet.org/v2.1.0/void.ttl#befree-20140225 http://purl.org/pav/2.0/importedOn 2014-02-25 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/eco.owl#ECO_0000212 http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v2.1.0/void.ttl#source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU130_publicationInfo http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/dc/terms/created 2014-10-02T12:37:38+02:00 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v2.1.0/void.ttl#IBIGroup http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/pav/2.0/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/pav/2.0/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/nanopublications.trig#NP561081.RAxHipv-BJ6Hy9VW2MIV6onGFCFdosEj8807ke2usD2rU http://purl.org/pav/2.0/version v2.1.0.0 http://rdf.disgenet.org/v2.1.0/void.ttl#disgenetrdf http://purl.org/pav/2.0/version v2.1.0