http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#Head http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#assertion http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#provenance http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#assertion http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_1 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/IL1%20Family http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:96559 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_2 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_1 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#assertion http://www.w3.org/2000/01/rdf-schema#label p(SFAM:"IL1 Family") -> r(MGI:Il6) http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_4 http://www.w3.org/ns/prov#value BACKGROUND: The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such as interleukin (IL)-6, leukemia-inhibitory factor (LIF), IL-11, and oncostatin M. This suggests that these cytokines might share common signaling pathways. We previously reported that CNTF augments the levels of corticosterone (CS) and of IL-6 induced by IL-1 and induces the production of the acute-phase protein serum amyloid A (SAA). Since the elevation of serum CS is an important feedback mechanism to limit the synthesis of proinflammatory cytokines, particularly tumor necrosis factor (TNF), we have investigated the effect of CNTF on both TNF production and lipopolysaccharide (LPS) toxicity. MATERIALS AND METHODS: To induce serum TNF levels, LPS was administered to mice at 30 mg/kg i.p. and CNTF was administered as a single dose of 10 micrograms/mouse i.v., either alone or in combination with its soluble receptor sCNTFR alpha at 20 micrograms/mouse. Serum TNF levels were the measured by cytotoxicity on L929 cells. In order to measure the effects of CNTF on LPS-induced TNF production in the brain, mice were injected intracerebroventricularly (i.c.v.) with 2.5 micrograms/kg LPS. Mouse spleen cells cultured for 4 hr with 1 microgram LPS/ml, with or without 10 micrograms CNTF/ml, were also analyzed for TNF production. RESULTS: CNTF, administered either alone or in combination with its soluble receptor, inhibited the induction of serum TNF levels by LPS. This inhibition was also observed in the brain when CNTF and LPS were administered centrally. In vitro, CNTF only marginally affected TNF production by LPS-stimulated mouse splenocytes, but it acted synergistically with dexamethasone (DEX) in inhibiting TNF production. Most importantly, CNTF administered together with sCNTFR alpha protected mice against LPS-induced mortality. CONCLUSIONS: These data suggest that CNTF might act as a protective cytokine against TNF-mediated pathologies both in the brain and in the periphery. http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8529123 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8529123 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#_4 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4 http://purl.org/dc/terms/created 2014-07-03T14:33:50.799+02:00 http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAxDBfTvbg_-EBzYTKfLdAbIPfPwsDGZ_Sp4Rre5so-i4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234