http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#Head http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#assertion http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#provenance http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#pubinfo http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#assertion http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6364 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0002367 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_1 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=16330 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:Stanolone) -> r(HGNC:KLK3) http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_3 http://www.w3.org/ns/prov#value Prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA) are the markers of human prostatic gland. However, it is still not completely understood if and how, steroid hormones and growth factors affect their expression and metabolism in the respect to the major pathologies of the gland. Appropriate studies were carried out on histopathologically diagnosed benign prostatic hyperplasia--BPH (n = 42) using tissue slices and cells derived from them. They were incubated with steroid hormones: 5-alpha-dihydrotestosterone (DHT), estradiol (E) and growth factors: epidermal growth factor (EGF), basic fibroblastic growth factor (bFGF) under culture conditions for up to 24 hours. P-labelled specific oligonucleotide probes were used to analyze total RNA isolated from each sample for the presence of PAP and PSA mRNAs. DHT, E, bFGF, EGF or both DHT + bFGF and DHT + EGF increased PAP and PSA mRNA levels in a time- and dose-dependent manner. The highest and statistically significant increase (P < 0.001) for PAP mRNA was observed when DHT + bFGF were present in the medium while for PSA mRNA if DHT + EGF were added to the medium. Slow but constant decrease of PAP and PSA mRNA levels was observed in the absence of each of these factors in the incubation medium. The results suggest that early expression of PSA and PAP genes and/or their mRNA stability strongly depend on DHT while differ in their response to EGF and bFGF. http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12362977 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12362977 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#_3 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog#pubinfo http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog http://purl.org/dc/terms/created 2014-07-03T14:31:55.222+02:00 http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAxBMoSBa_q_AX1-1UNK2TiECvh_RSq_vsaGAz0ncTtog http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234