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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAx72y68AQ0t1u1F7gHtjf3LjDToxf1gn8rmZRni5La4s#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAx72y68AQ0t1u1F7gHtjf3LjDToxf1gn8rmZRni5La4s#_5 http://www.w3.org/ns/prov#value PDK-1 is a downstream molecule of PI3K, which activates among many others, PKC-z (37). This protein kinase is a member of the atypical PKCs. Unlike conventional or novel PKCs, it does not require diacylglycerol or phorbol esters for its activation and its function is Ca2+ independent (38). 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