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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#_6 http://www.w3.org/ns/prov#value Second, our recent study suggests that binding of phospho-GSK-3b to ANT {Official Gene Symbol: Slc25a4} suppresses interaction of ANT with CypD {Official Gene Symbol: Ppid}, a trigger of mPTP opening.51 In isolated rat hearts, reperfusion after sustained ischemia induced translocation of cytosolic GSK-3b to the mitochondria, where it formed a complex with ANT and VDAC. Phosphorlylation of GSK-3b by ischemic preconditioning and erythropoietin (EPO) receptor activation was dependent on protein kinase C (PKC) and phosphatidiylinositol 3-phosphate kinase (PI3K), and phospho-GSK-3b was bound to ANT but not to VDAC at reperfusion (Figure 2A). {Phosphorylation of GSK3b is at what's described in the literature as Serine 9} http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19506320 http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19506320 http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#_6 http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ http://purl.org/dc/terms/created 2014-07-03T14:33:34.822+02:00 http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAwkjTxpvdCH5SGAhaFJxs7xBQW3vh2nQW7JWYhFeo9XQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234