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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAwZv3GDWEmldNiPWNsZySszQDh5DiAf2E6XQiFwAf7k0#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAwZv3GDWEmldNiPWNsZySszQDh5DiAf2E6XQiFwAf7k0#_6 http://www.w3.org/ns/prov#value We show that functional RhoA is required for LPA-, serum-, and AIF4--induced transcriptional activation by SRF and that tw~ other Rho family GTPases, Racl and CDC42Hs, can also potentiate SRF activity.......NIH 3T3 cells were transfected with CAT reporter genes controlled by either two copies of the wild-type c-los SRE, or its derivative SRE.L, which cannot bind TCF, together with expression plasmids producing the activated small GTPases Ras.R12, RhoA.V14, Rac1.V12, or CDC42Hs.......The serum response element (SRE) is a regulatory sequence found in many growth factor-regulated promoters (reviewed by Treisman, 1990). The SRE binds the ubiquitous transcription factor SRF (serum response factor; Norman et al., 1988), which is required for its activity. V12. 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