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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#_3 http://www.w3.org/ns/prov#value Nicotine or NNK (100 nM) increased proliferation ~2-fold in both cell lines. Immunoblotting analysis revealed that after daily administration of nicotine or NNK, Akt activation increased 41.5- fold in both cell lines. The reasons for the less robust increase in Akt activation on day 3 is unclear, but might be related to the higher dose (10 mM) or longer time course (5 days) used in Figure 4A. Increased NSCLC cell proliferation was associated with increased cyclin D1 expression http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15790591 http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15790591 http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#_3 http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE http://purl.org/dc/terms/created 2014-07-03T14:30:33.602+02:00 http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAwYzTbqmEtDsi_Rtl0LQ6lkcIZO-LSv4SZ_jL7DlrEaE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234