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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#_4 http://www.w3.org/ns/prov#value Analyses of a panel of fresh brain tumors (Fig. 1AFigure 1, Fig. S1A) demonstrated the ubiquitous and varied expression of HH-GLI pathway components including GLI1, SHH and PTCH1, confirming the general presence of an active pathway (Fig. 1AFigure 1, Figs. S1B, C, S2), as GLI1 transcription is the only reliable marker of pathway activity. .....Here we demonstrate that human gliomas and their cancer stem cells require HH-GLI pathway activity for proliferation, survival, self-renewal and tumorigenicity. http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17196391 http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17196391 http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#_4 http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw http://purl.org/dc/terms/created 2014-07-03T14:33:07.825+02:00 http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAwY3FZEk7KCuYiCwXCiSat4Ao2Vns98AVxLLCsyAI7cw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234