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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAwTSA7YagFbvX4k5R9yXXBJ1rlUUYkjySP6XT1L0VQAE#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAwTSA7YagFbvX4k5R9yXXBJ1rlUUYkjySP6XT1L0VQAE#_5 http://www.w3.org/ns/prov#value Treatment of human umbilical vein endothelial cells (HUVECs) with betacellulin (BTC, 10 ng/ml) increased phosphorylation of two MAPKs, ERK1 (p44MAPK) and ERK2 (p42MAPK) and AKT as early as 1 minute and produced a maximal effect at 5 minutes, which declined and returned to control levels at 60 minutes. BTC treatment also phosphorylated all three Erb receptors ErbB2, ErbB3, and ErbB4 but not ErbB1. 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