@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAwTSA7YagFbvX4k5R9yXXBJ1rlUUYkjySP6XT1L0VQAE> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAwTSA7YagFbvX4k5R9yXXBJ1rlUUYkjySP6XT1L0VQAE#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:1121;
    a Protein: .
  
  sub:_2 hasAgent: sub:_3;
    a go:0016301 .
  
  sub:_3 geneProductOf: hgnc:6871;
    a Protein: .
  
  sub:_4 occursIn: obo:EFO_0002795, species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:BTC) -> kin(p(HGNC:MAPK1))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_5 prov:value "Treatment of human umbilical vein endothelial cells (HUVECs) with betacellulin (BTC, 10 ng/ml) increased phosphorylation of two MAPKs, ERK1 (p44MAPK) and ERK2 (p42MAPK) and AKT as early as 1 minute and produced a maximal effect at 5 minutes, which declined and returned to control levels at 60 minutes. BTC treatment also phosphorylated all three Erb receptors ErbB2, ErbB3, and ErbB4 but not ErbB1. BTC induced phosphorylation of MAPK and AKT was not suppressed by a selectilvely inhibitory concentration of ErbB1 receptor inhibitor, AG1478), suggesting that BTC induced MAPK and AKT activation was mediated through ErbB4 homodimer, ErbB2/ErbB3, or ErbB2/ErbB4.";
    prov:wasQuotedFrom pubmed:12475887 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12475887;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:31:57.230+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}