http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#head http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ http://www.nanopub.org/nschema#hasAssertion http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#assertion http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ http://www.nanopub.org/nschema#hasProvenance http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#provenance http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ http://www.nanopub.org/nschema#hasPublicationInfo http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#publicationInfo http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#assertion http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/bio2rdf_vocabulary:identifier DB01583 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/bio2rdf_vocabulary:namespace drugbank http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/bio2rdf_vocabulary:uri http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org http://identifiers.org/drugbank/DB01583 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/drugbank_vocabulary:drugbank-id DB01583 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/drugbank_vocabulary:x-ahfs http://bio2rdf.org/ahfs:68:36.04 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/drugbank_vocabulary:x-cas http://bio2rdf.org/cas:8065-29-0 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/drugbank_vocabulary:x-chemspider http://bio2rdf.org/chemspider:64467 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb http://bio2rdf.org/pharmgkb:PA164748036 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound http://bio2rdf.org/pubchem.compound:71371 http://bio2rdf.org/drugbank:DB01583 http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance http://bio2rdf.org/pubchem.substance:46506203 http://bio2rdf.org/drugbank:DB01583 http://purl.org/dc/terms/description Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal secretion. It is now known that the thyroid gland secretes approximately ten times more T4 than T3 and that 80% of serum T3 is derived from deiodination of T4 in peripheral tissues. Administration of levothyroxine alone is sufficient for maintaining serum T4 and T3 levels in most patients and combination hormone replacement therapy generally offers no therapeutic advantage. In fact, administration of T3 may result in supratherapeutic levels of T3. http://bio2rdf.org/drugbank:DB01583 http://purl.org/dc/terms/identifier drugbank:DB01583 http://bio2rdf.org/drugbank:DB01583 http://purl.org/dc/terms/title Liotrix http://bio2rdf.org/drugbank:DB01583 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://bio2rdf.org/drugbank_vocabulary:Drug http://bio2rdf.org/drugbank:DB01583 http://www.w3.org/2000/01/rdf-schema#label Liotrix [drugbank:DB01583] http://bio2rdf.org/drugbank:DB01583 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugbank.ca/drugs/DB01583 http://bio2rdf.org/drugbank:DB01583 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugs.com/cdi/liotrix.html http://bio2rdf.org/drugbank:DB01583 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.rxlist.com/cgi/generic/liot.htm http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#provenance http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3 http://www.w3.org/ns/dcat#distribution http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://purl.org/dc/terms/created 2015-01-09T17:00:50-05:00 http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://purl.org/pav/retrievedOn 2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.w3.org/ns/prov#wasAttributedTo http://drugbank.ca http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#publicationInfo http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#signature.MC0CFQCTfqfvs1Ds http://purl.org/nanopub/x/hasPublicKey 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 http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#signature.MC0CFQCTfqfvs1Ds http://purl.org/nanopub/x/hasSignature MC0CFQCTfqfvs1Dsrk+wnvkYt4cDTdOK4gIUO359xy828l5/9IMxke3OwwF8kI8= http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#signature.MC0CFQCTfqfvs1Ds http://purl.org/nanopub/x/signedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ http://purl.org/dc/terms/created 2018-03-30T11:10:42.217+02:00 http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ http://purl.org/dc/terms/license https://creativecommons.org/licenses/by-nc/4.0/ http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ http://purl.org/nanopub/x/hasSignatureElement http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ#signature.MC0CFQCTfqfvs1Ds http://bio2rdf.org/drugbank:DB01583_nanopub.RAwQxKcIPhY6m6kH-bVzBxnhR9z06s6oA9k8NB6jbR4UQ http://www.w3.org/ns/prov#wasGeneratedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#specializationOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://purl.org/dc/terms/identifier 7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#used https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasAssociatedWith https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasStartedBy http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/dc/terms/isVersionOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/pav/version eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234