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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#_5 http://www.w3.org/ns/prov#value Using a series of experiments, we found that FoxH1 repressed both ligand-dependent and -independent transactivation of the AR on androgen-induced promoters. This action of FoxH1 was independent of its transactivation capacity and activin A but relieved by Smad2.Smad4. In addition, the repression of the AR by FoxH1 did not require deacetylase activity. A protein-protein interaction was identified between the AR and FoxH1 independently of dihydrotestosterone. Furthermore, a confocal microscopic analysis of LNCaP cells revealed that the interaction between the AR and FoxH1 occurred in the nucleus and that FoxH1 specifically blocked the foci formation of dihydrotestosterone-activated AR, which has been shown to be correlated with the AR transactivation potential. http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16120611 http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16120611 http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#_5 http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI http://purl.org/dc/terms/created 2014-07-03T14:32:49.381+02:00 http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAwOQGfZGd0oplFgsjr8TKC08sy3PqOj7uv9zTV3EZWmI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234