http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#Head http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#assertion http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#provenance http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#assertion http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_1 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/IL1%20Family http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:98229 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_2 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_1 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#assertion http://www.w3.org/2000/01/rdf-schema#label p(SFAM:"IL1 Family") -> r(MGI:Apcs) http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_4 http://www.w3.org/ns/prov#value C-Reactive protein (CRP) is a minor acute phase reactant (APR) in the mouse, whereas CRP is the prototypical and one of the major positive APRs in all other mammals. MoCRP gene expression was tissue specific for the liver and induced by culture supernatants of LPS-activated macrophages. MoCRP gene expression by isolated hepatocytes in culture increased c, 3-fold in response to interleukin (IL)-1, but not IL-6. IL-6 is the most potent inflammatory cytokine for the induction of human CRP and many other APRs. By contrast, gene expression of the major APR of the mouse, serum amyloid P-component (SAP), a structural homologue of CRP, increased in response to either IL-1 or IL-6 under the same conditions. The region containing two potentially IL-1 responsive C/EBP elements in the moCRP gene failed to respond to IL-1 when a pCAT construct containing the elements was transfected into Hep 3B2 hepatoma cells. Therefore, IL-1 may influence the expression of the moCRP gene at the post-transcriptional rather than at the transcriptional level. The findings suggest that moCRP may be a minor APR because of the limited response of the gene to inflammatory cytokine signals. http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8260597 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8260597 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#_4 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw http://purl.org/dc/terms/created 2014-07-03T14:33:49.635+02:00 http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAw0s30fMYky-Xeh91iDWwk4Xjv9QZdi_qA40h_9TYdSw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234