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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAvnKsQtr8MsHjGndTjBHtOinsXGlpv4ms7HQcwuspmaA#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAvnKsQtr8MsHjGndTjBHtOinsXGlpv4ms7HQcwuspmaA#_5 http://www.w3.org/ns/prov#value IL-1 at a concentration of 10ng/ml induced an hsp70 response in fibroblast like synoviocytes resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. Costimulation by TNF-alpha and IL-1 had an additive effect on both HSF1 activation and hsp70 expression. Activation of HSF1 by IL-1 was dose dependent between 5 and 15 ng/ml of cytokine added to cultures. 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