. . . . . . . . . . . . . . . "p(HGNC:IL1A) -> tscript(p(HGNC:HSF1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "IL-1 at a concentration of 10ng/ml induced an hsp70 response in fibroblast like synoviocytes resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. Costimulation by TNF-alpha and IL-1 had an additive effect on both HSF1 activation and hsp70 expression. Activation of HSF1 by IL-1 was dose dependent between 5 and 15 ng/ml of cytokine added to cultures. Time kinetics revealed maximum DNA binding activity of HSF1 after 3 hours of cytokine stimulation. IL1 treated cells showed the formation of the hyperphosphorylated higher molecular weight isoform of HSF1." . . "Selventa" . . . . "2014-07-03T14:31:00.108+02:00"^^ . . .