sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.4" .
  sub:_5 prov:value "IL-1 at a concentration of 10ng/ml induced an hsp70 response in fibroblast like synoviocytes resulting in transcriptional activation of HSF1 and enhanced hsp70 protein expression. Costimulation by TNF-alpha and IL-1 had an additive effect on both HSF1 activation and hsp70 expression. Activation of HSF1 by IL-1 was dose dependent between 5 and 15 ng/ml of cytokine added to cultures. Time kinetics revealed maximum DNA binding activity of HSF1 after 3 hours of cytokine stimulation. IL1 treated cells showed the formation of the hyperphosphorylated higher molecular weight isoform of HSF1." ;
    prov:wasQuotedFrom pubmed:9664071 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:9664071 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}