@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAvgFP6zbu3QZkj68TyJ88VrfTa8zzu6Q_rNJjwmkqZtw> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAvgFP6zbu3QZkj68TyJ88VrfTa8zzu6Q_rNJjwmkqZtw#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix scomp: <http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  scomp:AMP%20Activated%20Protein%20Kinase%20Complex a ProteinComplex: .
  
  sub:_1 hasAgent: scomp:AMP%20Activated%20Protein%20Kinase%20Complex;
    a go:0016301 .
  
  sub:_2 occursIn: obo:CL_0000182, obo:EFO_0002829, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject chebi:6801;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:metformin) -> kin(complex(SCOMP:\"AMP Activated Protein Kinase Complex\"))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "AMPK activation in the ?-cell to inhibit glucose metabolism and ATP production (see above), in stark contrast with the situation in most other cell types, where AMPK activation serves to stimulate glycolytic flux and to spare ATP consumption [193], or possibly to the inhibition of insulin release Moreover, metformin activates AMPK in both MIN6 cells and human islets (I. Leclerc, unpublished work), and leptin acutely inhibits insulin secretion from ?-cell lines and islets";
    prov:wasQuotedFrom pubmed:12839490 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12839490;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:04.064+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}